methoxyflurane and Kidney Diseases studies

Methoxyflurane: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
methoxyflurane : An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.

Research Excerpts

Excerpt	Relevance	Reference
" Single analgesic doses in modern use generally appear safe for patients."	2.72	Methoxyflurane toxicity: historical determination and lessons for modern patient and occupational exposure. ( Allison, SJ; Chase, JG; Docherty, PD; Pons, D, 2021)
"Methoxyflurane is a volatile, halogenated analgesic, self-administered in a controlled low dose from the Penthrox(®) inhaler for short-term pain relief."	2.53	Analgesic use of inhaled methoxyflurane: Evaluation of its potential nephrotoxicity. ( Dayan, AD, 2016)
"This article reviews the evidence for the analgesic efficacy of methoxyflurane in both prehospital and ED settings, as well as the adverse event profile associated with methoxyflurane use."	2.45	Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. ( Babl, FE; Grindlay, J, 2009)
"Phenobarbital pretreatment increased methoxyflurane nephrotoxicity in vivo (increased diuresis and blood urea nitrogen and decreased urine osmolality) and induced in vitro hepatic microsomal methoxyflurane metabolism to inorganic fluoride (2-fold), dichloroacetatic acid (1."	1.33	New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. ( Kharasch, ED; Liggitt, HD; Park, SB; Schroeder, JL; Sheffels, P; Whittington, D, 2006)
" Fluoride is one of many methoxyflurane metabolites and may itself cause toxicity and/or reflect formation of other toxic metabolite(s)."	1.33	New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. ( Ensign, D; Kharasch, ED; Liggitt, HD; Schroeder, JL; Whittington, D, 2006)
"Methoxyflurane nephrotoxicity is mediated by cytochrome P450-catalyzed metabolism to toxic metabolites."	1.29	Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. ( Hankins, DC; Kharasch, ED; Thummel, KE, 1995)
" The predominant factors in the production of methoxyflurane nephrotoxicity appear to be high methoxyflurane dosage and serum inorganic fluoride concentration."	1.26	Methoxyflurane nephropathy. ( Mazze, RI, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	71 (87.65)	18.7374
1990's	3 (3.70)	18.2507
2000's	4 (4.94)	29.6817
2010's	1 (1.23)	24.3611
2020's	2 (2.47)	2.80

Authors	Studies
Qizilbash, N	1
Kataria, H	1
Jarman, H	1
Bloom, B	1
Bradney, M	1
Oh, M	1
Yee, SA	1
Roncero, A	1
Mendez, I	1
Pocock, S	1
Allison, SJ	1
Docherty, PD	1
Pons, D	1
Chase, JG	1
Dayan, AD	1
Grindlay, J	1
Babl, FE	1
BALESTRA, L	1
GIARDINA, B	1
Kharasch, ED	3
Schroeder, JL	2
Liggitt, HD	2
Park, SB	1
Whittington, D	2
Sheffels, P	1
Ensign, D	1
Mazze, RI	15
Marier, JR	1
Cousins, MJ	11
Skowronski, G	1
Plummer, JL	2
Marek, J	1
Hradec, E	1
Baden, JM	1
Rice, SA	1
Dahlgren, BE	1
Van Dyke, RA	1
Kluwe, WM	1
Hook, JB	1
Hankins, DC	1
Thummel, KE	1
Bito, H	1
Conway, CM	1
Cohen, EN	1
Bell, LE	1
Hitt, BA	3
Bonora, M	1
Novello, F	1
Bonetti, E	1
Cetrullo, C	1
Ndiritu, CG	1
Weigel, J	1
Klemmer, PJ	1
Hadler, NM	1
Arthaud, LE	1
Loomis, TA	1
Brunner, FP	1
Thiel, G	1
Brodeur, J	1
Paquin, P	1
Authier, L	1
Geadah, D	1
Yamauchi, M	1
Côté, MG	1
Churchill, D	2
Yacoub, JM	1
Siu, KP	1
Symes, A	1
Gault, MH	2
Oyama, T	1
Kotrly, K	1
Barboriak, J	1
Henschel, EO	1
Fry, BW	1
Ciarlone, AE	1
Hall, PD	1
Jenner, MA	1
Ilsley, AH	1
Tobin, T	1
Akera, T	1
Dworin, JZ	1
Brody, TM	1
De Sousa, RC	1
Kistler, HJ	2
Schwitter, J	2
Kosek, JC	3
Love, FV	1
Stoianov, E	1
Minchev, M	1
Deseva, B	1
Dimitrov, D	1
Burson, ER	1
Stone, WA	1
Hamelberg, W	1
Pederson, JA	1
Hagler, L	1
Herman, RH	1
Gottlieb, LS	1
Trey, C	1
Barr, GA	1
Urgena, RB	1
Gergis, SD	1
Eknoyan, G	1
Lin, MK	1
Halpren, BA	1
Kempson, RL	1
Coplon, NS	1
Filipescu, Z	1
Tulbure, D	1
Baumann, U	1
Joshi, PH	1
Conn, HO	2
Knaack, J	1
Chirito, E	1
Barré, P	1
Cole, C	1
Muehrcke, R	1
Hamilton, WF	2
Robertson, GS	2
Desmond, JW	1
Cascorbi, HF	1
Gravenstein, JS	1
Nishimura, TG	1
Packer, KJ	1
Jones, NO	1
Goldman, EJ	2
Geerling, J	1
Shue, GL	1
Jackson, SH	1
Landesman, RH	1
Tucker, D	1
David, DS	1
West, JP	1
Kristoffersen, MB	1
Lapointe, A	1
Bele-Binda, N	1
Frascino, JA	1
Vanamee, P	1
Rosen, PP	1
Vandam, LD	1
Stoelting, RK	1
Kim, M	1
Gauert, WB	1
Schloerb, PR	1
Crandell, WB	1
Macdonald, A	1
Elkington, SG	1
Goffinet, JA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy and Safety of Methoxyflurane Vaporized (PENTHROX®) in the Treatment of Acute Trauma Pain in Pre-hospital Setting and in the Emergency Department in Italy: a Multicentre, Randomized, Controlled, Open-label Study[NCT03585374]	Phase 3	272 participants (Actual)	Interventional	2018-02-08	Completed
Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl Using Cold Pressor Test (CPT) in Volunteers: A Randomized, Double Blind, Placebo-controlled Crossover Study.[NCT03894800]	Phase 4	12 participants (Actual)	Interventional	2019-04-23	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Methoxyflurane toxicity: historical determination and lessons for modern patient and occupational exposure. The New Zealand medical journal, 2021, 04-30, Volume: 134, Issue:1534 Topics: Anesthetics, Inhalation; Health Personnel; Humans; Inhalation Exposure; Kidney Diseases; Methoxyflur	2021
Analgesic use of inhaled methoxyflurane: Evaluation of its potential nephrotoxicity. Human & experimental toxicology, 2016, Volume: 35, Issue:1 Topics: Anesthetics, Inhalation; Animals; Humans; Kidney Diseases; Methoxyflurane	2016
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:1 Topics: Adult; Analgesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Chemical and Drug Induced Liver I	2009
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:1 Topics: Adult; Analgesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Chemical and Drug Induced Liver I	2009
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:1 Topics: Adult; Analgesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Chemical and Drug Induced Liver I	2009
Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting. Emergency medicine Australasia : EMA, 2009, Volume: 21, Issue:1 Topics: Adult; Analgesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Chemical and Drug Induced Liver I	2009
Halogenated hydrocarbon environmental pollution: the special case of halogenated anesthetics. Environmental research, 1982, Volume: 28, Issue:1 Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Ethers; Halothane; Health Occupations; Humans;	1982
Anaesthesia and the kidney. Anaesthesia and intensive care, 1983, Volume: 11, Issue:4 Topics: Anesthesia; Anesthetics; Animals; Drug Interactions; Enflurane; Humans; Isoflurane; Kidney; Kidney D	1983
[Metabolism and toxicity of anesthetics]. Masui. The Japanese journal of anesthesiology, 1999, Volume: 48 Suppl Topics: Anesthetics, Inhalation; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver Injury; Enfluran	1999
Toxicity of inhalation anaesthetic agents. British journal of anaesthesia, 1978, Volume: 50, Issue:7 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersens	1978
Anaesthesia, surgery and renal function: immediate and delayed effects. Anaesthesia and intensive care, 1973, Volume: 1, Issue:5 Topics: Aldosterone; Anesthesia, Inhalation; Anesthetics; Angiotensin II; Animals; Dose-Response Relationshi	1973
[Diabetes insipidus--various recent aspects]. Schweizerische medizinische Wochenschrift, 1974, Jul-27, Volume: 104, Issue:30 Topics: Animals; Arginine; Carbamazepine; Chlorpropamide; Clofibrate; Cyclic AMP; Diabetes Insipidus; Hypoth	1974
Drug related iatrogenic renal disease: the antibiotics and anesthetics. The Journal of the Oklahoma State Medical Association, 1972, Volume: 65, Issue:4 Topics: Amphotericin B; Anti-Bacterial Agents; Glycosides; Humans; Iatrogenic Disease; Kidney Diseases; Meth	1972
Oxalate metabolism. IV. The American journal of clinical nutrition, 1973, Volume: 26, Issue:10 Topics: Animals; Calcinosis; Calcium; Ethylenes; Glycols; Humans; Kidney Calculi; Kidney Diseases; Metabolic	1973
The effects of fluorinated anesthetics on the liver and kidneys. Annual review of medicine, 1974, Volume: 25 Topics: Acute Kidney Injury; Adult; Anesthesia, Inhalation; Animals; Biotransformation; Chemical and Drug In	1974
[Parenchymal damage following Halothane and Methoxyflurane]. Der Anaesthesist, 1971, Volume: 20, Issue:11 Topics: Anesthesia, Inhalation; Biotransformation; Chemical and Drug Induced Liver Injury; Chemical Phenomen	1971
[Methoxifluranum]. Nordisk medicin, 1967, Feb-09, Volume: 77, Issue:6 Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Angiography; Cardiac Catheterization; Humans; Kidne	1967

Article	Year
Real world safety of methoxyflurane analgesia in the emergency setting: a comparative hybrid prospective-retrospective post-authorisation safety study. BMC emergency medicine, 2023, 08-30, Volume: 23, Issue:1 Topics: Adult; Analgesia; Anesthetics, Inhalation; Chemical and Drug Induced Liver Injury; Emergencies; Huma	2023
[COMPARATIVE EXPERIMENTAL STUDY OF THE HISTOLOGICAL CHANGES IN THE LIVER AND KIDNEY IN ACUTE POISONING BY CHLOROFORM, FLUOTHANE AND METHOCYFLURANE]. Minerva anestesiologica, 1964, Volume: 30 Topics: Anesthetics; Chemical and Drug Induced Liver Injury; Chloroform; Halothane; Hepatitis; Kidney; Kidne	1964
New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. Anesthesiology, 2006, Volume: 105, Issue:4 Topics: Anesthetics, Inhalation; Animals; Biotransformation; GABA Modulators; Kidney Diseases; Kidney Functi	2006
New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. Anesthesiology, 2006, Volume: 105, Issue:4 Topics: Anesthesiology; Anesthetics, Inhalation; Animals; Biotransformation; Dichloroacetic Acid; Dose-Respo	2006
Methoxyflurane revisited: tale of an anesthetic from cradle to grave. Anesthesiology, 2006, Volume: 105, Issue:4 Topics: Anesthesiology; Anesthetics, Inhalation; Animals; Fluorides; History, 20th Century; Humans; Kidney D	2006
[Massive oxalosis of the kidney in association with anesthesia using methoxyflurane]. Ceskoslovenska patologie, 1984, Volume: 20, Issue:3 Topics: Adult; Anesthesia; Calcium Oxalate; Crystallization; Humans; Kidney; Kidney Diseases; Male; Methoxyf	1984
Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats. Anesthesiology, 1982, Volume: 56, Issue:3 Topics: Anesthesia; Animals; Deuterium; Enzyme Induction; Fluorides; Kidney; Kidney Diseases; Male; Methoxyf	1982
Hepatic and renal effects of low concentrations of methoxyflurane in exposed delivery ward personnel. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1980, Volume: 22, Issue:12 Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Urea Nitrogen; Chemical and Drug Induced Li	1980
Toxic metabolites from biotransformation: major organ damage. International anesthesiology clinics, 1981,Winter, Volume: 19, Issue:4 Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Enflurane; Ether; H	1981
Metabolic activation of nephrotoxic haloalkanes. Federation proceedings, 1980, Volume: 39, Issue:13 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chloroform; Humans; Hydrocarbons, Halogen	1980
Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology, 1995, Volume: 82, Issue:3 Topics: Cytochrome P-450 Enzyme System; Ethers; Fluorides; Humans; In Vitro Techniques; Isoenzymes; Kidney;	1995
Editorial: "Old lamps for new". British journal of anaesthesia, 1975, Volume: 47, Issue:8 Topics: Anesthesia, Inhalation; Arrhythmias, Cardiac; Enflurane; Ethers; Halothane; Humans; Isoflurane; Kidn	1975
The influence of age on the distribution, metabolism and excretion of methoxyflurane in Fischer 344 rats: a possible relationship to nephrotoxicity. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 195, Issue:1 Topics: Aging; Anesthesia; Animals; Carbon Dioxide; Fluorides; Hydrogen-Ion Concentration; Kidney Diseases;	1975
RNA-synthesis in rat kidneys after fluorinated anesthetics or inorganic fluoride administration. Experientia, 1979, Jan-15, Volume: 35, Issue:1 Topics: Animals; Depression, Chemical; Enflurane; Fluorides; Halothane; Kidney; Kidney Diseases; Male; Metho	1979
Hepatorenal injury in a dog associated with methoxyflurane (a case report). Veterinary medicine, small animal clinician : VM, SAC, 1977, Volume: 72, Issue:4 Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female;	1977
Effect of enzyme induction on nephrotoxicity of halothane-related compounds. Environmental health perspectives, 1977, Volume: 21 Topics: Anesthetics; Animals; Biotransformation; Enflurane; Environmental Exposure; Enzyme Induction; Fluori	1977
Subacute fluorosis: a consequence of abuse of an organofluoride anesthetic. Annals of internal medicine, 1978, Volume: 89, Issue:5 Pt 1 Topics: Acute Disease; Adult; Bone and Bones; Chronic Disease; Female; Fluorides; Humans; Hypertension; Kidn	1978
Methoxyflurane-induced nephrotoxicity: influence of food intake on some biochemical indicators of renal function in Fischer 344 rats. Toxicology and applied pharmacology, 1978, Volume: 45, Issue:3 Topics: Animals; Body Weight; Diuresis; Drinking; Eating; Female; Fluorides; Kidney Diseases; Kidney Functio	1978
[Diagnosis and pathophysiology of renal concentration disorders]. Schweizerische medizinische Wochenschrift, 1976, Sep-18, Volume: 106, Issue:38 Topics: Demeclocycline; Diabetes Insipidus; Diabetes Mellitus; Diuretics; Fanconi Syndrome; Humans; Hypercal	1976
Influence of phenobarbital pretreatment on methoxyflurane and sodium fluoride nephropathy in Fischer 344 Rats. Toxicology and applied pharmacology, 1976, Volume: 37, Issue:2 Topics: Animals; Fluorides; Kidney Diseases; Male; Methoxyflurane; Phenobarbital; Rats; Rats, Inbred F344	1976
Methoxyflurane nephropathy. Environmental health perspectives, 1976, Volume: 15 Topics: Age Factors; Animals; Child; Dose-Response Relationship, Drug; Fluorides; Gentamicins; Humans; Kidne	1976
Toxic nephropathy after low-dose methoxyflurane anesthesia: drug interaction with secobarbital? Canadian Medical Association journal, 1976, Feb-21, Volume: 114, Issue:4 Topics: Drug Interactions; Enzyme Induction; Humans; Kidney; Kidney Diseases; Male; Methoxyflurane; Microsom	1976
Nephrotoxic effect of methoxyflurane anesthesia. A case report. Der Anaesthesist, 1976, Volume: 25, Issue:1 Topics: Anesthesia, Inhalation; Drug Hypersensitivity; Female; Humans; Kidney Diseases; Methoxyflurane; Midd	1976
Perdeuteration of methoxyflurane reduces production of fluorometabolites in mice. Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:2 Topics: Animals; Body Weight; Fluorides; Kidney Diseases; Male; Methoxyflurane; Mice; Postural Balance; Refl	1990
Hepatic and renal effects of prolonged exposure of rats to 50 p.p.m. methoxyflurane. Acta pharmacologica et toxicologica, 1985, Volume: 57, Issue:3 Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Fatty Liver; Fluorides; Halothane; Kid	1985
Editorial: Methoxyflurane nephrotoxicity. British medical journal, 1974, May-04, Volume: 2, Issue:5913 Topics: Anesthesia; Enzyme Inhibitors; Fluorides; Humans; Kidney Diseases; Methoxyflurane; Oxalates	1974
Fluoride nephropathy: lack of direct involvement of renal ATPase. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Fluori	1974
[Proceedings: Kidney disease due to methoxyflurane (Penthrane)]. Helvetica medica acta, 1974, Volume: 37, Issue:5-6 Topics: Anesthesia, Inhalation; Blood; Diabetes Insipidus; Female; Humans; Hysterectomy; Kidney Diseases; Ma	1974
Letter: Methoxyflurane nephrotoxicity. British medical journal, 1974, Aug-24, Volume: 3, Issue:5929 Topics: Animals; Disease Models, Animal; Enzyme Induction; Fluorides; Humans; Kidney Concentrating Ability;	1974
The etiology of methoxyflurane nephrotoxicity. The Journal of pharmacology and experimental therapeutics, 1974, Volume: 190, Issue:3 Topics: Animals; Fluorides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Liver; Male; Methoxyflurane;	1974
Letter: Methoxyflurane nephrotoxicity. Canadian Anaesthetists' Society journal, 1974, Volume: 21, Issue:6 Topics: Humans; Kidney; Kidney Diseases; Methoxyflurane; Research Design	1974
[The effect of methoxyflurane anesthesia on renal function]. Khirurgiia, 1974, Volume: 27, Issue:6 Topics: Anesthesia, General; Humans; Kidney Diseases; Methoxyflurane	1974
Methoxyflurane and renal dysfunction: a review. The Journal of the American Association of Nurse Anesthetists, 1972, Volume: 40, Issue:5 Topics: Kidney Diseases; Methoxyflurane	1972
Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyflurane in rats. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 184, Issue:2 Topics: Anesthesia, Inhalation; Animals; Blood Urea Nitrogen; Fluorides; Kidney; Kidney Diseases; Kidney Tub	1973
An animal model for combined methoxyflurane and gentamicin nephrotoxicity. British journal of anaesthesia, 1973, Volume: 45, Issue:4 Topics: Anesthesia; Animals; Blood Urea Nitrogen; Drug Synergism; Fluorides; Gentamicins; Kidney; Kidney Dis	1973
Nephrotoxicity from methoxyflurane anaesthesia: a 6-year retrospective study. British journal of anaesthesia, 1973, Volume: 45, Issue:4 Topics: Anesthesia, Inhalation; Diuresis; Humans; Kidney Diseases; Male; Methoxyflurane; Middle Aged; Postop	1973
Combined nephrotoxicity of gentamicin and methoxyflurane anaesthesia in man. A case report. British journal of anaesthesia, 1973, Volume: 45, Issue:4 Topics: Anesthesia, Inhalation; Blood Urea Nitrogen; Body Weight; Creatinine; Drug Synergism; Fluorides; Gen	1973
Toxic nephropathies. Texas medicine, 1973, Volume: 69, Issue:7 Topics: Aspirin; Gentamicins; Humans; Kidney Diseases; Methoxyflurane; Phenacetin	1973
[Nephrotoxic effect of the concurrent use of methoxyfluranie and antibiotics]. Masui. The Japanese journal of anesthesiology, 1973, Volume: 22, Issue:3 Topics: Anesthesia, Inhalation; Animals; Anti-Bacterial Agents; Female; Kanamycin; Kidney Diseases; Male; Me	1973
Interstitial fibrosis and chronic renal failure following methoxyflurane anesthesia. JAMA, 1973, Mar-12, Volume: 223, Issue:11 Topics: Aged; Anesthetics; Anuria; Autopsy; Biopsy; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic	1973
[Data on the nephrotoxicity of penthrane]. Chirurgia, 1973, Volume: 22, Issue:10 Topics: Anesthesia; Humans; Kidney Diseases; Methoxyflurane	1973
[Methoxyflurane-induced nephropathy]. Schweizerische medizinische Wochenschrift, 1974, Feb-02, Volume: 104, Issue:5 Topics: Acute Kidney Injury; Diabetes Insipidus; Female; Humans; Hypernatremia; Kidney; Kidney Diseases; Mal	1974
The syndrome of methoxyflurane-associated hepatitis. Annals of internal medicine, 1974, Volume: 80, Issue:3 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Hypersensitivity;	1974
Persisting renal insufficiency after methoxyflurane anesthesia. Report of two cases and review of literature. The American journal of medicine, 1974, Volume: 56, Issue:4 Topics: Acute Kidney Injury; Aged; Anesthesia; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Kidne	1974
Changes in serum uric acid related to the dose of methoxyflurane. British journal of anaesthesia, 1974, Volume: 46, Issue:1 Topics: Anesthesia, General; Dose-Response Relationship, Drug; Fluorides; Halothane; Humans; Kidney Diseases	1974
Changes in urine osmolality and urine fluoride concentrations following methoxyflurane anaesthesia. British journal of anaesthesia, 1974, Volume: 46, Issue:2 Topics: Anesthesia, General; Dose-Response Relationship, Drug; Fluorides; Halothane; Humans; Kidney Diseases	1974
Methoxyflurane nephrotoxicity. Canadian Anaesthetists' Society journal, 1974, Volume: 21, Issue:3 Topics: Anesthesia, Inhalation; Follow-Up Studies; Humans; Kidney; Kidney Diseases; Kidney Function Tests; M	1974
Renal effects of low-dose methoxyflurane with cardiopulmonary bypass. Anesthesiology, 1972, Volume: 36, Issue:3 Topics: Adjuvants, Anesthesia; Anesthesia, General; Blood Urea Nitrogen; Creatinine; Extracorporeal Circulat	1972
Nephrotoxicity from methoxyfluorane. British medical journal, 1972, Mar-25, Volume: 1, Issue:5803 Topics: Animals; Drug Synergism; Fluorides; Humans; Kidney; Kidney Diseases; Methoxyflurane; Rats	1972
Methoxyflurane analgesia for burns dressings. Postgraduate medical journal, 1972, Volume: 48, Issue:557 Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Burns; Child; Child, Preschool; Female; Humans; Inf	1972
Methoxyflurane nephrotoxicity--a review and a case report. Canadian Anaesthetists' Society journal, 1972, Volume: 19, Issue:2 Topics: Anesthesia, General; Blood Urea Nitrogen; Creatinine; Humans; Kidney; Kidney Diseases; Male; Methoxy	1972
Methoxyflurane anesthesia in a febrile patient. Medical trial technique quarterly, 1972, Volume: 18, Issue:4 Topics: Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Diverticulitis, Colonic; Fever; Huma	1972
[Effect of methoxyflurane anesthesia on the kidney]. Nederlands tijdschrift voor geneeskunde, 1972, Jun-17, Volume: 116, Issue:25 Topics: Humans; Kidney; Kidney Diseases; Methoxyflurane	1972
Methoxyflurane anesthesia. JAMA, 1971, Apr-19, Volume: 216, Issue:3 Topics: Drug Tolerance; Humans; Jaundice; Kidney; Kidney Diseases; Male; Methoxyflurane	1971
Methoxyflurane nephrotoxicity. JAMA, 1971, Aug-16, Volume: 217, Issue:7 Topics: Humans; Kidney; Kidney Diseases; Kidney Tubules; Lipid Metabolism; Methoxyflurane; Obesity	1971
Methoxyflurane and renal dysfunction. JAMA, 1971, Sep-27, Volume: 217, Issue:13 Topics: Adult; Humans; Kidney; Kidney Diseases; Male; Methoxyflurane; Polyuria	1971
Methoxyflurane anesthesia. Archives of pathology, 1971, Volume: 92, Issue:6 Topics: Biotransformation; Fluorides; Humans; Kidney Calculi; Kidney Diseases; Methoxyflurane; Oxalates	1971
Fluorine compounds in biological materials. Ciba Foundation symposium, 1971, Volume: 2 Topics: Blood Proteins; Chromatography; Electrophoresis, Paper; Fluorine; Halothane; Humans; Kidney Diseases	1971
[Nephrotoxicity associated with methoxyflurane]. Canadian Anaesthetists' Society journal, 1970, Volume: 17, Issue:2 Topics: Adult; Aged; Anesthesia, Inhalation; Diabetes Mellitus; Female; Humans; Kidney Diseases; Male; Metho	1970
Renal oxalosis and azotemia after methoxyflurane anesthesia. The New England journal of medicine, 1970, Sep-24, Volume: 283, Issue:13 Topics: Acute Kidney Injury; Anesthesia, Inhalation; Autopsy; Biopsy; Creatinine; Histocytochemistry; Humans	1970
The crystal ball. The New England journal of medicine, 1970, Sep-24, Volume: 283, Issue:13 Topics: Acute Kidney Injury; Anesthesia, Inhalation; Autopsy; Biopsy; Calcium; Humans; Kidney; Kidney Diseas	1970
Methoxyflurane anesthesia and renal function. The New England journal of medicine, 1970, Nov-26, Volume: 283, Issue:22 Topics: Anesthesia; Humans; Kidney; Kidney Diseases; Methoxyflurane; Oxalates	1970
Halothane anesthesia following methoxyflurane-induced nephrotoxicity. Anesthesiology, 1970, Volume: 33, Issue:4 Topics: Anesthesia, Inhalation; Castration; Diabetes Insipidus; Female; Halothane; Humans; Hysterectomy; Kid	1970
Renal ischemia and anesthesia. Southern medical journal, 1971, Volume: 64, Issue:8 Topics: Anesthesia, Inhalation; Animals; Blood Urea Nitrogen; Ethyl Ethers; Halothane; Ischemia; Kidney; Kid	1971
Nephropathy associated with methoxyflurane anesthesia. A follow-up report. JAMA, 1968, Sep-09, Volume: 205, Issue:11 Topics: Diagnosis, Differential; Follow-Up Studies; Glucose; Humans; Kidney Diseases; Kidney Function Tests;	1968
Renal and hepatic injury associated with methoxyflurane anesthesia. Annals of internal medicine, 1968, Volume: 69, Issue:6 Topics: Anesthesia, Inhalation; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Temperature; Chemical	1968

methoxyflurane and Kidney Diseases

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