methoxyflurane has been researched along with Acute Pain in 22 studies
Methoxyflurane: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
methoxyflurane : An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We aim to establish whether non-invasive methods such as inhalation of methoxyflurane is non-inferior to intranasal fentanyl or non-inferior to the well-known IV morphine in the pre-hospital treatment of acute pain." | 9.69 | Comparison of three regimens with inhalational methoxyflurane versus intranasal fentanyl versus intravenous morphine in pre-hospital acute pain management: study protocol for a randomized controlled trial (PreMeFen). ( Fjose, LO; Hagemo, J; Heyerdahl, F; Rehn, M; Simensen, R; Thorsen, K, 2023) |
| "Methoxyflurane is more effective than MEOPA in acute pain in burn dressing, improved patient comfort, and improved dressing quality." | 9.34 | [Use of methoxyflurane on acute pain during burn dressing in adult consultation]. ( Bertrand-Vasseur, A; Duteille, F; Leduc, A; Perrot, P; Verdier, J, 2020) |
| "To evaluate the short-term efficacy and safety of methoxyflurane for the treatment of acute pain in patients presenting to an emergency department (ED) with minor trauma." | 9.19 | STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain. ( Coffey, F; Dissmann, P; Hartshorn, S; Hunt, P; Locker, T; Mirza, K; Wright, J, 2014) |
| "A short-cut review of the literature was carried out to establish whether inhaled methoxyflurane (Penthrox) is comparable or superior with a standard inhalational analgesia for the management of acute pain." | 9.01 | BET 1: Green or blue for you? Methoxyflurane (Penthrox) or nitrous oxide/oxygen 50% mixture (Entonox) for the management of acute pain in the ED. ( Quinn, E; Rahman, SM, 2019) |
| "Methoxyflurane is more effective than MEOPA in acute pain in burn dressing, improved patient comfort, and improved dressing quality." | 5.34 | [Use of methoxyflurane on acute pain during burn dressing in adult consultation]. ( Bertrand-Vasseur, A; Duteille, F; Leduc, A; Perrot, P; Verdier, J, 2020) |
| "Methoxyflurane use was also associated with lower median pain scores at all time points." | 3.01 | Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care. ( Brichko, L; Cameron, P; Gaddam, R; Jennings, P; Luckhoff, C; Mitra, B; O'Reilly, G; Roman, C; Smit, V, 2021) |
| " Adverse events (all non-serious) were reported by 17% of methoxyflurane-treated patients and 3% of SAT-treated patients." | 2.90 | Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA). ( Bonafede, E; Carpinteri, G; Fabbri, A; Farina, A; Gangitano, G; Intelligente, F; Mercadante, S; Ruggiano, G; Sblendido, A; Serra, S; Soldi, A; Voza, A, 2019) |
| "Treatment of acute pain is a central task in emergency medicine." | 2.82 | [Volatile anesthetics for prehospital analgesia by paramedics-An overview]. ( Beywinkler, C; Doppler, R; Egger, A; Kreutziger, J; Trimmel, H; Voelckel, WG, 2022) |
| "Methoxyflurane treatment was rated 'Excellent', 'Very Good' or 'Good' by 77." | 2.82 | Methoxyflurane Analgesia in Adult Patients in the Emergency Department: A Subgroup Analysis of a Randomized, Double-blind, Placebo-controlled Study (STOP!). ( Coffey, F; Dissmann, P; Lomax, M; Mirza, K, 2016) |
| "Adult patients with moderate to severe trauma pain and Glasgow coma score of 15 were included in the evaluation." | 1.56 | Service Evaluation of Methoxyflurane Versus Standard Care for Overall Management of Patients with Pain Due to Injury. ( Bailey, GP; McKinlay, JAC; Young, L, 2020) |
| "Acute trauma pain is poorly managed in the emergency department (ED)." | 1.56 | Multiple criteria decision analysis approach to consider therapeutic innovations in the emergency department: The methoxyflurane organizational impact in acute trauma pain. ( Diallo, ML; Dussart, C; Hadjadj-Baillot, C; Lapostolle, F; Lvovschi, VE; Maignan, M; Pons-Kerjean, N; Tazarourte, K, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 14 (63.64) | 2.80 |
| Authors | Studies |
|---|---|
| Johansson, A | 1 |
| Svensson, A | 1 |
| Wihlborg, J | 1 |
| Trimmel, H | 2 |
| Egger, A | 2 |
| Doppler, R | 1 |
| Beywinkler, C | 1 |
| Voelckel, WG | 1 |
| Kreutziger, J | 1 |
| Wood, C | 1 |
| Huber, T | 1 |
| Heschl, S | 1 |
| Fiegl, J | 1 |
| Burger, J | 1 |
| Schreiber, W | 1 |
| Niederer, M | 1 |
| Tscherny, K | 1 |
| Roth, D | 1 |
| Ghazali, DA | 1 |
| Bouzid, D | 1 |
| Frachon, A | 1 |
| Ait-Abdesselam, S | 1 |
| Kenway, P | 1 |
| Choquet, C | 1 |
| Casalino, E | 1 |
| Simensen, R | 1 |
| Fjose, LO | 1 |
| Rehn, M | 1 |
| Hagemo, J | 1 |
| Thorsen, K | 1 |
| Heyerdahl, F | 1 |
| Mercadante, S | 1 |
| Voza, A | 1 |
| Serra, S | 1 |
| Ruggiano, G | 3 |
| Carpinteri, G | 3 |
| Gangitano, G | 1 |
| Intelligente, F | 1 |
| Bonafede, E | 3 |
| Sblendido, A | 4 |
| Farina, A | 4 |
| Soldi, A | 4 |
| Fabbri, A | 3 |
| Borobia, AM | 1 |
| Collado, SG | 1 |
| Cardona, CC | 1 |
| Pueyo, RC | 1 |
| Alonso, CF | 1 |
| Torres, IP | 1 |
| González, MC | 1 |
| Casal Codesido, JR | 1 |
| Betegón, MA | 1 |
| Barcela, LA | 1 |
| Andicoechea, AO | 1 |
| Testa, AF | 1 |
| Colina, JT | 1 |
| Dorribo, AC | 1 |
| Del Arco Galán, C | 1 |
| Martínez Ávila, JC | 1 |
| Lugilde, ST | 1 |
| Carcas Sansuán, AJ | 1 |
| Lim, KJ | 1 |
| Koh, ZX | 1 |
| Ng, YY | 1 |
| Fook-Chong, S | 1 |
| Ho, AFW | 1 |
| Doctor, NE | 1 |
| Said, NAZM | 1 |
| Ong, MEH | 1 |
| Lojo Rial, C | 1 |
| Ozainne, F | 1 |
| Fehlmann, C | 1 |
| Von Düring, S | 1 |
| Cottet, P | 1 |
| Young, L | 1 |
| Bailey, GP | 1 |
| McKinlay, JAC | 1 |
| Ricard-Hibon, A | 1 |
| Lecoules, N | 1 |
| Savary, D | 1 |
| Jacquin, L | 1 |
| Wiel, E | 1 |
| Deschamps, P | 1 |
| Douplat, M | 1 |
| Montestruc, F | 1 |
| Chomier, B | 1 |
| Tazarourte, K | 2 |
| Adnet, F | 1 |
| Lvovschi, VE | 1 |
| Maignan, M | 1 |
| Diallo, ML | 1 |
| Hadjadj-Baillot, C | 1 |
| Pons-Kerjean, N | 1 |
| Lapostolle, F | 1 |
| Dussart, C | 1 |
| Brichko, L | 1 |
| Gaddam, R | 1 |
| Roman, C | 1 |
| O'Reilly, G | 1 |
| Luckhoff, C | 1 |
| Jennings, P | 1 |
| Smit, V | 1 |
| Cameron, P | 1 |
| Mitra, B | 1 |
| Marinangeli, F | 1 |
| Reggiardo, G | 1 |
| Montassier, E | 1 |
| Freund, Y | 1 |
| Verdier, J | 1 |
| Leduc, A | 1 |
| Duteille, F | 1 |
| Bertrand-Vasseur, A | 1 |
| Perrot, P | 1 |
| Rahman, SM | 1 |
| Quinn, E | 1 |
| Coffey, F | 2 |
| Wright, J | 1 |
| Hartshorn, S | 1 |
| Hunt, P | 1 |
| Locker, T | 1 |
| Mirza, K | 2 |
| Dissmann, P | 2 |
| Lomax, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Methoxyflurane Vaporized (PENTHROX®) in the Treatment of Acute Trauma Pain in Pre-hospital Setting and in the Emergency Department in Italy: a Multicentre, Randomized, Controlled, Open-label Study[NCT03585374] | Phase 3 | 272 participants (Actual) | Interventional | 2018-02-08 | Completed | ||
| Open Randomized Clinical Trial to Compare Pain Relief Between Methoxyflurane and Standard of Care for Treating Patients With Trauma Pain in Spanish Emergency Units.[NCT03256903] | Phase 3 | 310 participants (Actual) | Interventional | 2017-07-07 | Completed | ||
| A Randomised, Double Blind, Multi-centre, Placebo Controlled Study to Evaluate the Efficacy and Safety of Methoxyflurane (Penthrox) for the Treatment of Acute Pain in Patients Presenting to an Emergency Department With Minor Trauma[NCT01420159] | Phase 3 | 300 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methoxyflurane and Acute Pain
| Article | Year |
|---|---|
[Volatile anesthetics for prehospital analgesia by paramedics-An overview].
Topics: Acute Pain; Adult; Allied Health Personnel; Anesthetics; Child; Emergency Medical Services; Humans; | 2022 |
[Acute pain management : the role of inhaled methoxyflurane in clinical practice].
Topics: Acute Pain; Anesthetics, Inhalation; Humans; Methoxyflurane; Pain Management; Switzerland | 2020 |
BET 1: Green or blue for you? Methoxyflurane (Penthrox) or nitrous oxide/oxygen 50% mixture (Entonox) for the management of acute pain in the ED.
Topics: Acute Pain; Analgesics; Emergency Service, Hospital; Humans; Methoxyflurane; Nitrous Oxide; Oxygen; | 2019 |
11 trials available for methoxyflurane and Acute Pain
| Article | Year |
|---|---|
Comparison of three regimens with inhalational methoxyflurane versus intranasal fentanyl versus intravenous morphine in pre-hospital acute pain management: study protocol for a randomized controlled trial (PreMeFen).
Topics: Acute Pain; Fentanyl; Hospitals; Humans; Methoxyflurane; Morphine; Randomized Controlled Trials as T | 2023 |
Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA).
Topics: Acetaminophen; Acute Pain; Administration, Intravenous; Adult; Analgesics; Anesthetics, Inhalation; | 2019 |
Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments.
Topics: Acute Pain; Administration, Inhalation; Aged; Analgesia; Analgesics; Anesthetics, Inhalation; Emerge | 2020 |
Comparison of inhalational methoxyflurane (Penthrox®) and intramuscular tramadol for prehospital analgesia.
Topics: Acute Pain; Ambulances; Analgesia; Anesthetics, Inhalation; Humans; Methoxyflurane; Pain Measurement | 2021 |
Inhaled methoxyflurane for the management of trauma related pain in patients admitted to hospital emergency departments: a randomised, double-blind placebo-controlled trial (PenASAP study).
Topics: Acute Pain; Adult; Analgesia; Analgesics, Opioid; Anesthetics, Inhalation; Double-Blind Method; Emer | 2020 |
Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care.
Topics: Acute Pain; Adult; Anesthetics, Inhalation; Australia; Emergency Service, Hospital; Humans; Methoxyf | 2021 |
Prospective, Multicentre Trial of Methoxyflurane for Acute Trauma-Related Pain in Helicopter Emergency Medical Systems and Hostile Environments: METEORA Protocol.
Topics: Acute Pain; Administration, Inhalation; Adult; Aircraft; Anesthetics, Inhalation; Emergency Medical | 2018 |
Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA).
Topics: Acute Pain; Administration, Inhalation; Adult; Anesthetics, Inhalation; Drug Monitoring; Emergency M | 2019 |
[Use of methoxyflurane on acute pain during burn dressing in adult consultation].
Topics: Acute Pain; Adult; Anesthetics, Inhalation; Bandages; Burns; Female; Humans; Male; Methoxyflurane; N | 2020 |
STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Inhalation; Double-B | 2014 |
STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Inhalation; Double-B | 2014 |
STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Inhalation; Double-B | 2014 |
STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain.
Topics: Acute Pain; Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthetics, Inhalation; Double-B | 2014 |
Methoxyflurane Analgesia in Adult Patients in the Emergency Department: A Subgroup Analysis of a Randomized, Double-blind, Placebo-controlled Study (STOP!).
Topics: Acute Pain; Adolescent; Adult; Analgesia; Anesthetics, Inhalation; Dose-Response Relationship, Drug; | 2016 |
8 other studies available for methoxyflurane and Acute Pain
| Article | Year |
|---|---|
Pain management with methoxyflurane (Penthrox®) in Swedish ambulance care - An observational pilot study.
Topics: Acute Pain; Ambulances; Anesthetics, Inhalation; Female; Humans; Male; Methoxyflurane; Pain Manageme | 2021 |
Trauma pain management in the emergency department: use of methoxyflurane as a patient-administered analgesic.
Topics: Acute Pain; Analgesics; Anesthetics, Inhalation; COVID-19; Emergency Service, Hospital; Humans; Meth | 2022 |
Efficacy and Safety of Methoxyflurane for Treatment of Acute Traumatic Pain by EMTs during Alpine Rescue Operations: The "PainDrop" Trial.
Topics: Acute Pain; Adult; Analgesics; Anesthetics, Inhalation; Emergency Medical Services; Female; Humans; | 2023 |
Pain Self-Management with Inhaled Methoxyflurane by Emergency Department Trauma Patients: A Prospective, Interventional, Single-Center Study.
Topics: Acute Pain; Analgesics; Anesthetics, Inhalation; COVID-19; Emergency Service, Hospital; Humans; Meth | 2023 |
Service Evaluation of Methoxyflurane Versus Standard Care for Overall Management of Patients with Pain Due to Injury.
Topics: Acute Pain; Adult; Anesthetics, Inhalation; Emergency Service, Hospital; Female; Glasgow Coma Scale; | 2020 |
Multiple criteria decision analysis approach to consider therapeutic innovations in the emergency department: The methoxyflurane organizational impact in acute trauma pain.
Topics: Acute Pain; Anesthetics, Inhalation; Clinical Decision-Making; Critical Pathways; Crowding; Decision | 2020 |
A Rigorous Evaluation of Methoxyflurane is Needed: Comment on "Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)".
Topics: Acute Pain; Emergency Service, Hospital; Humans; Italy; Methoxyflurane; Standard of Care | 2019 |
Response to "A Rigorous Evaluation of Methoxyflurane is Needed: Comment on 'Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)'".
Topics: Acute Pain; Emergency Service, Hospital; Humans; Italy; Methoxyflurane; Standard of Care | 2019 |