methoxychlor has been researched along with Carcinoma, Hepatocellular in 3 studies
Methoxychlor: An insecticide. Methoxychlor has estrogenic effects in mammals, among other effects.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Flutamide was a complete agonist, whereas its hydroxylated metabolite, hydroxyflutamide, only partially antagonized and displayed some agonist activity at 10(-6) M and above." | 1.30 | Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. ( Gaido, KW; Maness, SC; McDonnell, DP, 1998) |
| "Human hepatoma cells (HepG2) were transiently transfected with either human or rat ERalpha or ERbeta plus an estrogen-responsive, complement 3-luciferase construct containing a complement 3 gene promoter sequence linked to a luciferase reporter gene." | 1.30 | Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. ( Gaido, KW; Hall, JM; Leonard, LS; Maness, SC; McDonnell, DP; Safe, S; Saville, B, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horng, CT | 1 |
| Chou, CT | 1 |
| Tseng, HW | 1 |
| Cheng, JS | 1 |
| Chang, HT | 1 |
| Chang, PM | 1 |
| Chen, IL | 1 |
| Hung, MC | 1 |
| Tsai, YJ | 1 |
| Tsai, PC | 1 |
| Liang, WZ | 1 |
| Kuo, CC | 1 |
| Kuo, DH | 1 |
| Ho, CM | 1 |
| Lin, JR | 1 |
| Shieh, P | 1 |
| Jan, CR | 1 |
| Maness, SC | 2 |
| McDonnell, DP | 2 |
| Gaido, KW | 2 |
| Leonard, LS | 1 |
| Hall, JM | 1 |
| Saville, B | 1 |
| Safe, S | 1 |
3 other studies available for methoxychlor and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Effect of methoxychlor on Ca²⁺ homeostasis and apoptosis in HA59T human hepatoma cells.
Topics: Apoptosis; Calcium; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relati | 2015 |
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Antineoplastic Agents, Hormonal; Car | 1998 |
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta.
Topics: Animals; Carcinoma, Hepatocellular; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor | 1999 |