methoxyamine has been researched along with Colonic Neoplasms in 5 studies
methoxyamine: analytical reagent for aldehydes and ketones; strong irritant, can probably produce methemoglobinemia; RN given refers to parent cpd; structure
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three human colon cancer cell lines were used, SW480 cells, which are wild-type for mismatch repair genes and have mutated p53, HCT116 cells, which are mutant in hMLH1 and wild-type for p53, and HCT15 cells, which are mutant in hMSH6 and mutant in p53 as well." | 1.31 | Base excision repair as a therapeutic target in colon cancer. ( Gerson, SL; Liu, L; Nakatsuru, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Condie, AG | 1 |
| Yan, Y | 1 |
| Gerson, SL | 4 |
| Wang, Y | 1 |
| Liu, L | 3 |
| Nakatsuru, Y | 1 |
| Berry, SE | 1 |
| Loh, T | 1 |
| Yan, T | 1 |
| Kinsella, TJ | 2 |
| Taverna, P | 2 |
| Whitacre, CM | 1 |
| Chatterjee, S | 1 |
| Hwang, HS | 1 |
| Hanson, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/II Trial of TRC102 (Methoxyamine HCl) in Combination With Temozolomide in Patients With Relapsed Solid Tumors and Lymphomas[NCT01851369] | Phase 1/Phase 2 | 93 participants (Actual) | Interventional | 2013-07-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for methoxyamine and Colonic Neoplasms
| Article | Year |
|---|---|
A Fluorescent Probe to Measure DNA Damage and Repair.
Topics: Animals; Base Pairing; Base Sequence; Binding Sites; Cattle; Cell Line, Tumor; Colonic Neoplasms; DN | 2015 |
Base excision repair as a therapeutic target in colon cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Base Pair Mismatch; Bone Marrow Diseases; Chromosome Abe | 2002 |
Role of MutSalpha in the recognition of iododeoxyuridine in DNA.
Topics: Adaptor Proteins, Signal Transducing; Base Pair Mismatch; Carrier Proteins; Cell Nucleus; Colonic Ne | 2003 |
Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.
Topics: Antineoplastic Agents, Alkylating; Carmustine; Cell Cycle; Colonic Neoplasms; Dacarbazine; DNA Repai | 1999 |
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells.
Topics: Apoptosis; Blotting, Western; Colonic Neoplasms; Dacarbazine; DNA Damage; DNA Repair; DNA, Neoplasm; | 2001 |