methoxsalen and Skin Diseases studies

Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Research Excerpts

Excerpt	Relevance	Reference
"Photochemotherapy using methoxsalen in combination with long-wave ultraviolet light (PUVA) is an essential modality in the treatment of various skin diseases."	4.80	PUVA therapy: current concerns in Japan. ( Danno, K, 1999)
"To understand the photobiological effects and to increase the safety and effectiveness of this novel topical PUVA therapy, we assessed the kinetics and dose-response of phototoxicity of 8-methoxypsoralen (8-MOP) cream in order to develop a treatment schedule for this treatment option."	2.70	Kinetics and dose-response of photosensitivity in cream psoralen plus ultraviolet A photochemotherapy: comparative in vivo studies after topical application of three standard preparations. ( Grundmann-Kollmann, M; Kaufmann, R; Ludwig, R; Ochsendorf, FR; Podda, M; Tegeder, I; Zollner, TM, 2001)
"Three phototherapeutic regimens with photosensitization are now used in dermatology: PUVA (psoralen + UVA), TUV (crude coaltar + UV), PRT (phototherapy with hematoporphyrin derivative)."	2.37	[Problems posed by the therapeutic use of photosensitizers in dermatology]. ( Amblard, P; Beani, JC; Reymond, JL, 1986)
"Methoxsalen (8-MOP) may cause important pharmacokinetic drug interactions as it has been shown to inhibit and/or induce several drug-metabolizing enzymes in vitro, in animal models and in humans."	1.31	Liver cytochrome P450 CYP1A2 is markedly inhibited by systemic but not by bath PUVA in dermatological patients. ( Fuhr, U; Scharffetter-Kochanek, K; Servera-Llaneras, M; Tantcheva-Poór, I, 2001)
"A 23-year-old man with Langerhans cell histiocytosis presented with asymptomatic, purplish, slightly scaly, confluent papules of one year's duration."	1.30	Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy. ( Cho, KH; Kwon, OS; Song, KY, 1997)
" In one patient who showed a lower absorption rate of 8-MOP plasma levels varied from 0-126 ng/ml."	1.26	Intraindividual variations of 8-methoxypsoralen plasma levels. ( Korting, HC; Schäfer-Korting, M, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (60.00)	18.7374
1990's	12 (24.00)	18.2507
2000's	5 (10.00)	29.6817
2010's	3 (6.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Rodighiero, P	1
Guiotto, A	1
Chilin, A	1
Bordin, F	1
Baccichetti, F	1
Carlassare, F	1
Vedaldi, D	2
Caffieri, S	2
Pozzan, A	1
Dall'Acqua, F	2
Guillon, CD	1
Jan, YH	1
Foster, N	1
Ressner, J	1
Heck, DE	1
Laskin, JD	1
Heindel, ND	1
Olisova, OY	1
Grabovskaya, OV	1
Teplyuk, NP	1
Tertychnyy, AS	1
Varshavsky, VA	1
Grekova, EV	1
Mok, ZR	1
Tan, ES	1
Chong, WS	1
TOLMAN, MM	1
WILGRAM, GF	1
Pozo-Román, T	1
González-López, A	1
Velasco-Vaquero, ME	1
Núñez-Cabezón, M	1
Jansén, CT	1
Wilén, G	1
Paul, R	1
Westphal, HJ	1
Gschnait, F	1
Wolff, K	1
Hönigsmann, H	3
Stingl, G	1
Brenner, W	1
Jaschke, E	1
Konrad, K	1
Schäfer-Korting, M	1
Korting, HC	1
Garde, E	1
Micic, S	1
Knudsen, K	1
Angelo, HR	1
Wulf, HC	1
Nivsarkar, M	1
Kumar, GP	1
Laloraya, M	1
Knobler, RM	2
Trautinger, F	1
Graninger, W	1
Macheiner, W	1
Gruenwald, C	1
Neumann, R	1
Ramer, W	1
Kwon, OS	1
Cho, KH	1
Song, KY	1
Danno, K	1
Shephard, SE	1
Panizzon, RG	1
Greinix, HT	1
Volc-Platzer, B	1
Kalhs, P	1
Fischer, G	1
Rosenmayr, A	1
Keil, F	1
Grundmann-Kollmann, M	1
Tegeder, I	1
Ochsendorf, FR	1
Zollner, TM	1
Ludwig, R	1
Kaufmann, R	1
Podda, M	1
Tantcheva-Poór, I	1
Servera-Llaneras, M	1
Scharffetter-Kochanek, K	1
Fuhr, U	1
Schiener, R	1
Behrens-Williams, SC	1
Pillekamp, H	1
Peter, RU	1
Kerscher, M	1
Denk, R	1
Oberste-Lehn, H	1
Mortazawi, SA	1
Greaves, MW	1
Weber, G	2
Briffa, DV	1
Warin, AP	2
Cox, AJ	2
Abel, EA	1
Burger, PM	1
Simons, JW	1
Dorval, JC	1
Leroy, JP	1
Massé, R	1
Greene, I	1
Wiskemann, A	1
Poyzer, K	1
Lobel, E	1
King, R	1
Le Guay, J	1
Paver, K	1
Brückner, V	1
Vella Briffa, D	1
Hofmann, C	2
Plewig, G	2
Braun-Falco, O	2
Nath, G	1
Kreitmair, A	1
Lowe, NJ	1
Bures, F	1
Rau, RC	1
Flowers, FP	1
Barrett, JL	1
Stáva, Z	1
Zala, L	1
Omar, A	1
Krebs, A	1
Anders, A	1
Lamprecht, I	1
Schaefer, H	1
Zacharias, H	1
Sinclair, R	1
Roelandts, R	1
Marrakchi, S	1
Decloquement, L	1
Pollet, P	1
Briand, G	1
Loesche, C	1
Bocquet, JL	1
Degand, P	1
Thomas, P	1
Eppinger, T	1
Ehninger, G	2
Steinert, M	2
Niethammer, D	1
Dopfer, R	2
Young, AR	1
Jaschonek, K	1
Einsele, H	1
Schmidt, H	1
Lenz, HJ	1
Beani, JC	1
Amblard, P	1
Reymond, JL	1
Andreassi, L	1
Bovalini, L	1
Martelli, P	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Single Arm Study of Extracorporeal Photoimmune Therapy With Uvadex For Corticosteroid Sparing in Patients With Corticosteroid-Dependent Crohn's Disease Who May Also Be Refractory or Intolerant to Immunosuppressants and/or Anti-Tumor Necrosis Factor Agen[NCT00056355]			Phase 1	10 participants	Interventional	2003-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
PUVA therapy: current concerns in Japan. Journal of dermatological science, 1999, Volume: 19, Issue:2 Topics: Humans; Japan; Methoxsalen; Photosensitizing Agents; PUVA Therapy; Skin Diseases; Skin Neoplasms	1999
Dermatology. The Practitioner, 1976, Volume: 217, Issue:1300 SPEC Topics: Acne Vulgaris; Anti-Bacterial Agents; Humans; Methoxsalen; Psoriasis; Rosacea; Skin Diseases; Skin D	1976
Photochemotherapy in psoriasis: a review. Journal of the Royal Society of Medicine, 1979, Volume: 72, Issue:6 Topics: Animals; Cataract; Humans; Methoxsalen; Mutagens; Photochemotherapy; Psoriasis; Rats; Skin Diseases;	1979
[Problems posed by the therapeutic use of photosensitizers in dermatology]. Biochimie, 1986, Volume: 68, Issue:6 Topics: 5-Methoxypsoralen; Coal Tar; DNA; Furocoumarins; Hematoporphyrin Derivative; Hematoporphyrin Photora	1986
Psoralen photochemotherapy--mechanisms, drugs, toxicity. Current problems in dermatology, 1986, Volume: 15 Topics: DNA; Erythema; Furocoumarins; Humans; Methoxsalen; Neoplasms, Radiation-Induced; Photosensitivity Di	1986

Article	Year
Angular furoquinolinones, psoralen analogs: novel antiproliferative agents for skin diseases. Synthesis, biological activity, mechanism of action, and computer-aided studies. Journal of medicinal chemistry, 1996, Mar-15, Volume: 39, Issue:6 Topics: DNA; Furocoumarins; Mutagens; Myoviridae; Photochemotherapy; RNA; Skin Diseases	1996
Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorganic & medicinal chemistry letters, 2019, 02-15, Volume: 29, Issue:4 Topics: Cell Survival; Cells, Cultured; Darkness; Humans; Keratinocytes; Light; Methoxsalen; Photosensitizin	2019
Cutaneous pseudolymphoma caused by Poly Implant Prothèse breast implants. Journal of the European Academy of Dermatology and Venereology : JEADV, 2018, Volume: 32, Issue:9 Topics: Adult; Breast Implants; Female; Humans; Methoxsalen; Photochemotherapy; Pseudolymphoma; Silicone Gel	2018
Treatment of cutaneous plasmacytosis with mask-bath PUVA: A therapeutic option. The Australasian journal of dermatology, 2017, Volume: 58, Issue:1 Topics: Adult; Baths; Chronic Disease; Humans; Hypergammaglobulinemia; Male; Methoxsalen; Photosensitizing A	2017
Advances in the treatment of skin diseases. The Practitioner, 1962, Volume: 189 Topics: Adrenal Cortex Hormones; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antin	1962
Psoralen cream plus ultraviolet A photochemotherapy (PUVA cream): our experience. Journal of the European Academy of Dermatology and Venereology : JEADV, 2006, Volume: 20, Issue:2 Topics: Administration, Cutaneous; Adult; Aged; Chemistry, Pharmaceutical; Female; Humans; Male; Methoxsalen	2006
Variations in skin photosensitization during repeated oral 8-methoxypsoralen medication. Archives of dermatological research, 1983, Volume: 275, Issue:5 Topics: Administration, Oral; Adult; Female; Humans; Male; Methoxsalen; Middle Aged; Photochemotherapy; PUVA	1983
[Local PUVA therapy with a modified 8-methoxypsoralen solution]. Dermatologische Monatschrift, 1984, Volume: 170, Issue:4 Topics: Dimethyl Sulfoxide; Drug Therapy, Combination; Humans; Methoxsalen; Photochemotherapy; PUVA Therapy;	1984
Long-term photochemotherapy: histopathological and immunofluorescence observations in 243 patients. The British journal of dermatology, 1980, Volume: 103, Issue:1 Topics: Adult; Antibodies, Antinuclear; Fluorescent Antibody Technique; Humans; Methoxsalen; Middle Aged; Ph	1980
Intraindividual variations of 8-methoxypsoralen plasma levels. Archives of dermatological research, 1982, Volume: 272, Issue:1-2 Topics: Adult; Aged; Biological Availability; Female; Humans; Intestinal Absorption; Liver; Male; Metabolic	1982
8-methoxypsoralen increases daytime plasma melatonin levels in humans through inhibition of metabolism. Photochemistry and photobiology, 1994, Volume: 60, Issue:5 Topics: Adult; Animals; Antimetabolites; Female; Humans; Male; Melatonin; Methoxsalen; Middle Aged; PUVA The	1994
Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy. Biochemical and biophysical research communications, 1994, Mar-30, Volume: 199, Issue:3 Topics: Animals; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Ethylmaleimide	1994
Parenteral administration of 8-methoxypsoralen in photopheresis. Journal of the American Academy of Dermatology, 1993, Volume: 28, Issue:4 Topics: Administration, Oral; Capsules; Cell Survival; Chromatography, High Pressure Liquid; Humans; Infusio	1993
Primary cutaneous Langerhans cell histiocytosis treated with photochemotherapy. The Journal of dermatology, 1997, Volume: 24, Issue:1 Topics: Administration, Oral; Adult; Epidermis; Follow-Up Studies; Histiocytes; Histiocytosis, Langerhans-Ce	1997
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy. Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:2 Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans	1999
Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study. Blood, 2000, Oct-01, Volume: 96, Issue:7 Topics: Acute Disease; Adult; Biopsy; Drug Resistance; Female; Gastrointestinal Hemorrhage; Graft vs Host Di	2000
Liver cytochrome P450 CYP1A2 is markedly inhibited by systemic but not by bath PUVA in dermatological patients. The British journal of dermatology, 2001, Volume: 144, Issue:6 Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Baths; Caffeine; Cytochrome P-450 CYP1	2001
Does the minimal phototoxic dose after 8-methoxypsoralen baths correlate with the individual's skin phototype? Photodermatology, photoimmunology & photomedicine, 2001, Volume: 17, Issue:4 Topics: Data Interpretation, Statistical; Ficusin; Humans; Methoxsalen; Photochemotherapy; Skin Diseases; St	2001
[Inclusion of clinical-dermatological therapy into general practice? (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1979, Jan-26, Volume: 121, Issue:4 Topics: Family Practice; Humans; Keratosis; Methotrexate; Methoxsalen; Patient Care Team; Photochemotherapy;	1979
[Therapeutic results of 8-methoxypsoralen (8-MOP) and UVR (ultraviolet rays)]. Zeitschrift fur Hautkrankheiten, 1975, Jul-01, Volume: 50, Issue:13 Topics: Acne Vulgaris; Adult; Aged; Eczema; Female; Humans; Male; Methoxsalen; Psoriasis; Skin Diseases; Ult	1975
[Utilisation of photochemotherapy by UVA and locally applied psoralens (author's transl)]. Annales de dermatologie et de venereologie, 1977, Volume: 104, Issue:5 Topics: Acne Vulgaris; Eczema; Humans; Methoxsalen; Mycosis Fungoides; Photochemotherapy; Psoriasis; Skin Di	1977
Epidermal dystrophy. Occurrence after psoriasis therapy with psoralen and long-wave ultraviolet light. Archives of dermatology, 1979, Volume: 115, Issue:5 Topics: Epidermis; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin; Skin Diseases	1979
Mutagenicity of 8-methoxypsoralen and long-wave ultraviolet irradiation in V-79 Chinese hamster cells. A first approach to a risk estimate in photochemotherapy. Mutation research, 1979, Volume: 60, Issue:3 Topics: Animals; Cell Line; Cricetinae; Methoxsalen; Mutagens; Photochemotherapy; Risk; Skin Diseases; Ultra	1979
[Disseminated granuloma annulare following puvatherapy]. Annales de dermatologie et de venereologie, 1979, Volume: 106, Issue:1 Topics: Aged; Granuloma; Humans; Male; Methoxsalen; Photochemotherapy; Psoriasis; Skin Diseases	1979
Amyloid deposition after psoriasis therapy with psoralen and long-wave ultraviolet light. Archives of dermatology, 1979, Volume: 115, Issue:10 Topics: Amyloidosis; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin; Skin Diseases	1979
[Adverse effects in the treatment of psoriasis]. ZFA. Zeitschrift fur Allgemeinmedizin, 1979, Oct-20, Volume: 55, Issue:29 Topics: Atrophy; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin Diseases; Ultraviolet Therapy	1979
Australian experience with PUVA. The Australasian journal of dermatology, 1979, Volume: 20, Issue:3 Topics: Humans; Methoxsalen; Photochemotherapy; Skin Diseases	1979
Photosensitizers and radiosensitizers in dermatology and oncology. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Sep-22, Volume: 56, Issue:13 Topics: Brain Neoplasms; DNA; Humans; Methoxsalen; Metronidazole; Misonidazole; Mycosis Fungoides; Photochem	1979
Photo-onycholysis caused by photochemotherapy. British medical journal, 1977, Oct-29, Volume: 2, Issue:6095 Topics: Humans; Methoxsalen; Nails; Skin Diseases; Ultraviolet Therapy	1977
[Unusual adverse effects of oral photochemotherapy (PUVA-therapy) in psoriasis]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1977, Volume: 28, Issue:11 Topics: Adult; Female; Humans; Hypertrichosis; Light; Male; Methoxsalen; Middle Aged; Nails; Photochemothera	1977
A new apparatus for the delivery of high intensity UVA and UVA+UVB irradiation, and some dermatological applications. The British journal of dermatology, 1978, Volume: 98, Issue:1 Topics: Acrodermatitis; Adult; Aged; Erythema; Erythropoiesis; Female; Humans; Male; Methoxsalen; Photochemo	1978
Woronoff's rings with PUVA therapy. Archives of dermatology, 1978, Volume: 114, Issue:2 Topics: Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin Diseases; Ultraviolet Therapy	1978
Photo-onycholysis secondary to psoralen use. Archives of dermatology, 1978, Volume: 114, Issue:3 Topics: Adult; Female; Humans; Methoxsalen; Nails; Photosensitivity Disorders; Skin Diseases	1978
[XV. International Dermatological Congress in Mexico 1977: I. Oral photochemotherapy with the use of methoxsalen]. Ceskoslovenska dermatologie, 1978, Volume: 53, Issue:3 Topics: Administration, Oral; Humans; Methoxsalen; Photochemotherapy; Skin Diseases	1978
Photo-onycholysis induced by 8-methoxypsoralen. Dermatologica, 1977, Volume: 154, Issue:4 Topics: Administration, Oral; Adult; Cytoplasmic Granules; Epithelial Cells; Epithelium; Female; Fibroblasts	1977
The use of dye lasers for spectroscopic investigations and photodynamic therapy of human skin. Archives for dermatological research = Archiv fur dermatologische Forschung, 1976, Apr-21, Volume: 255, Issue:2 Topics: Humans; Laser Therapy; Lasers; Methoxsalen; Phototherapy; Pyronine; Skin; Skin Diseases; Spectrophot	1976
Proceedings: Effects and side-effects of 8-methoxypsoralen-blacklight-therapy in more than 1500 patients. The British journal of dermatology, 1976, Volume: 95 Suppl 14 Topics: Humans; Methoxsalen; Psoriasis; Skin Diseases; Ultraviolet Therapy	1976
A review of the 1992 annual meeting of the British Society for Investigative Dermatology. The Australasian journal of dermatology, 1992, Volume: 33, Issue:3 Topics: Genes, p53; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin Diseases; Vitiligo	1992
The history of photochemotherapy. Photodermatology, photoimmunology & photomedicine, 1991, Volume: 8, Issue:5 Topics: History, 20th Century; History, Medieval; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Skin Di	1991
Variation in 8-methoxypsoralen profiles during long-term psoralen plus ultraviolet A therapy and correlations between serum 8-methoxypsoralen levels and chromametric parameters. Photodermatology, photoimmunology & photomedicine, 1991, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aged; Female; Humans; Male; Methoxsalen; Middle Aged; PUVA Therapy; Skin Diseases	1991
8-Methoxypsoralen and ultraviolet A therapy for cutaneous manifestations of graft-versus-host disease. Transplantation, 1990, Volume: 50, Issue:5 Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Female; Graft vs Host Disease; Humans; Male;	1990
To tan or not to tan. Archives of dermatology, 1990, Volume: 126, Issue:5 Topics: 5-Methoxypsoralen; Animals; Humans; Methoxsalen; Mice; Mice, Hairless; Skin Diseases; Sunscreening A	1990
8-Methoxypsoralen and ultraviolet A therapy for cutaneous manifestations of graft-versus-host disease. Lancet (London, England), 1988, Mar-12, Volume: 1, Issue:8585 Topics: Graft vs Host Disease; Humans; Methoxsalen; PUVA Therapy; Skin Diseases	1988
Khellin, a naturally occurring furochromone, used for the photochemotherapy of skin diseases: mechanism of action. Il Farmaco; edizione scientifica, 1988, Volume: 43, Issue:4 Topics: Animals; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Cross-Linking Reagents; Dialysis;	1988

methoxsalen and Skin Diseases

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