methoxsalen has been researched along with Sclerosis, Systemic in 14 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "One patient with generalized morphea had stopped EP after 3 months because of loss of vascular access and could not be evaluated." | 2.68 | Extracorporeal photochemotherapy in systemic sclerosis and severe morphea. ( Cribier, B; Faradji, T; Grosshans, E; Le Coz, C; Oberling, F, 1995) |
| "Seventy-nine patients with systemic sclerosis of recent onset (mean symptom duration, 1." | 2.67 | Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial. ( Barr, WG; Freundlich, B; Jegasothy, BV; Jimenez, SA; Kahaleh, MB; Perez, MI; Rietschel, RL; Rook, AH; Varga, J; Wintroub, B, 1992) |
| "Nine patients with active progressive systemic sclerosis were treated with extracorporeal photochemotherapy on 2 successive days monthly." | 1.29 | Extracorporeal photochemotherapy in progressive systemic sclerosis. ( Bisaccia, E; Cahill, C; Cottrill, C; Degnan, E; Di Spaltro, FX; Franks, AJ; Klainer, AS; Mulford, GJ; Scarborough, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papp, G | 1 |
| Horvath, IF | 1 |
| Barath, S | 1 |
| Gyimesi, E | 1 |
| Vegh, J | 1 |
| Szodoray, P | 1 |
| Zeher, M | 1 |
| Samimi, S | 1 |
| Rook, AH | 2 |
| Hayashi, S | 1 |
| Ikeda, M | 1 |
| Kitamura, Y | 1 |
| Hamasaki, Y | 1 |
| Hatamochi, A | 1 |
| Trautinger, F | 1 |
| Just, U | 1 |
| Knobler, R | 1 |
| Hashikabe, M | 1 |
| Ohtsuka, T | 1 |
| Yamazaki, S | 1 |
| Di Spaltro, FX | 1 |
| Cottrill, C | 1 |
| Cahill, C | 1 |
| Degnan, E | 1 |
| Mulford, GJ | 1 |
| Scarborough, D | 1 |
| Franks, AJ | 1 |
| Klainer, AS | 1 |
| Bisaccia, E | 1 |
| Cribier, B | 1 |
| Faradji, T | 1 |
| Le Coz, C | 1 |
| Oberling, F | 1 |
| Grosshans, E | 1 |
| Morison, WL | 1 |
| Balogh, A | 2 |
| Merkel, U | 2 |
| Looks, A | 2 |
| Vollandt, R | 2 |
| Wollina, U | 2 |
| Zic, JA | 1 |
| Miller, JL | 1 |
| Stricklin, GP | 1 |
| King, LE | 1 |
| Muellegger, RR | 1 |
| Hofer, A | 1 |
| Salmhofer, W | 1 |
| Soyer, HP | 1 |
| Kerl, H | 1 |
| Wolf, P | 1 |
| Freundlich, B | 1 |
| Jegasothy, BV | 1 |
| Perez, MI | 1 |
| Barr, WG | 1 |
| Jimenez, SA | 1 |
| Rietschel, RL | 1 |
| Wintroub, B | 1 |
| Kahaleh, MB | 1 |
| Varga, J | 1 |
| Trentham, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effectiveness of ECP in Diffuse Cutaneous Systemic Sclerosis[NCT04986605] | Phase 2 | 15 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methoxsalen and Sclerosis, Systemic
| Article | Year |
|---|---|
Photopheresis (extracorporeal photochemotherapy).
Topics: Graft Rejection; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photophere | 2013 |
The North American experience with photopheresis.
Topics: Arthritis, Rheumatoid; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Nort | 1999 |
6 trials available for methoxsalen and Sclerosis, Systemic
| Article | Year |
|---|---|
Quantitative echographic analysis of photochemotherapy on systemic sclerosis skin.
Topics: Adult; Aged; Dermis; Female; Humans; Male; Methoxsalen; Middle Aged; Photopheresis; Scleroderma, Sys | 2005 |
Extracorporeal photochemotherapy in systemic sclerosis and severe morphea.
Topics: Adolescent; Adult; Aged; Arthritis; Disease Progression; Drug Tolerance; Esophageal Diseases; Female | 1995 |
Plasma and buffy coat concentration of 8-methoxypsoralen in patients treated with extracorporeal photopheresis.
Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Female; Humans; Leukapheresis; Lymphoma, T-Cell; M | 1998 |
Drug monitoring of orally administered 8-methoxypsoralen in patients treated with extracorporeal photopheresis.
Topics: Adult; Area Under Curve; Female; Humans; Lymphoma, T-Cell; Male; Methoxsalen; Middle Aged; Photopher | 1998 |
Extended extracorporeal photochemotherapy with extracorporeal administration of 8-methoxypsoralen in systemic sclerosis. An Austrian single-center study.
Topics: Adult; Aged; Austria; Combined Modality Therapy; Female; Humans; Methoxsalen; Middle Aged; Photochem | 2000 |
Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial.
Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Immunotherapy; Leukapheresis; Leukocytes; Ma | 1992 |
6 other studies available for methoxsalen and Sclerosis, Systemic
| Article | Year |
|---|---|
Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis.
Topics: Adult; Case-Control Studies; Combined Modality Therapy; Cytokines; Female; Humans; Male; Methoxsalen | 2012 |
The relevance of photopheresis to autoreactive diseases.
Topics: Cytokines; Female; Humans; Male; Methoxsalen; Photopheresis; Scleroderma, Systemic | 2012 |
UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin.
Topics: Administration, Cutaneous; Animals; Bleomycin; Collagen Type I; Collagen Type III; Disease Models, A | 2012 |
Extracorporeal photochemotherapy in progressive systemic sclerosis.
Topics: Activities of Daily Living; Adult; Aged; Female; Humans; Kidney; Leukapheresis; Lung; Male; Methoxsa | 1993 |
Psoralen UVA therapy for linear and generalized morphea.
Topics: Adolescent; Adult; Dermatitis, Phototoxic; Female; Follow-Up Studies; Humans; Male; Methoxsalen; Mid | 1997 |
Photochemotherapy in systemic sclerosis. The stage is set.
Topics: Humans; Leukocytes; Methoxsalen; Penicillamine; Photochemotherapy; Scleroderma, Systemic; Ultraviole | 1992 |