methoxsalen has been researched along with Melanoma in 16 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 7.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| "Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis." | 7.69 | Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. ( Nichols, KT; Stern, RS; Väkevä, LH, 1997) |
| "The objectives of this study were to investigate the melanogenetic potential of the psoralen derivatives 5-hydroxypsoralen, 5-methoxypsoralen, 8-hydroxypsoralen, 8-methoxypsoralen, and 5,8-dimethoxypsoralen in B16F10 melanoma cells." | 4.12 | Mechanistic Insights into the Ameliorating Effect of Melanogenesis of Psoralen Derivatives in B16F10 Melanoma Cells. ( Hyun, CG; Lee, Y, 2022) |
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 3.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| "Oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is a highly effective therapy for psoriasis and many other skin conditions." | 3.71 | The risk of melanoma in association with long-term exposure to PUVA. ( Stern, RS, 2001) |
| "Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis." | 3.69 | Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. ( Nichols, KT; Stern, RS; Väkevä, LH, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, Y | 1 |
| Hyun, CG | 1 |
| Wróblewska-Łuczka, P | 1 |
| Grabarska, A | 1 |
| Florek-Łuszczki, M | 1 |
| Plewa, Z | 1 |
| Łuszczki, JJ | 1 |
| Ghosh, S | 1 |
| Bishayee, K | 1 |
| Khuda-Bukhsh, AR | 1 |
| Menichini, F | 2 |
| Tundis, R | 1 |
| Loizzo, MR | 1 |
| Bonesi, M | 1 |
| Provenzano, E | 1 |
| de Cindio, B | 1 |
| TOLMAN, MM | 1 |
| WILGRAM, GF | 1 |
| Isoldi, MC | 2 |
| Pereira, EA | 1 |
| Visconti, MA | 1 |
| Castrucci, AM | 2 |
| Cao, H | 1 |
| Hearst, JE | 1 |
| Corash, L | 1 |
| Wang, Y | 1 |
| Borkovic, SP | 1 |
| Alper, JC | 1 |
| McDonald, CJ | 1 |
| Shimada, S | 1 |
| Kawashima, M | 1 |
| Watanabe, S | 1 |
| Yamada, K | 1 |
| Mizoguchi, M | 1 |
| Hori, Y | 1 |
| Kukita, A | 1 |
| Epenetos, AA | 1 |
| Haciyakupoğlu, G | 1 |
| Varinli, I | 1 |
| Memişoğlu, HR | 1 |
| Varinli, S | 1 |
| Demircan, N | 1 |
| Denli, G | 1 |
| Stern, RS | 2 |
| Nichols, KT | 1 |
| Väkevä, LH | 1 |
| Hannuksela-Svahn, A | 1 |
| Pukkala, E | 1 |
| Koulu, L | 1 |
| Jansén, CT | 1 |
| Karvonen, J | 1 |
| Scarparo, AC | 1 |
| Schumacher, RI | 1 |
| Lerner, AB | 1 |
1 review available for methoxsalen and Melanoma
| Article | Year |
|---|---|
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
Topics: Adult; Female; Humans; Hydroquinones; Male; Melanoma; Melanosis; Methoxsalen; Nevus, Pigmented; Para | 1992 |
15 other studies available for methoxsalen and Melanoma
| Article | Year |
|---|---|
Mechanistic Insights into the Ameliorating Effect of Melanogenesis of Psoralen Derivatives in B16F10 Melanoma Cells.
Topics: 5-Methoxypsoralen; Animals; beta Catenin; Cell Line, Tumor; Ficusin; Furocoumarins; Melanins; Melano | 2022 |
Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coumarins; Drug Synergism; Furocoumarins | 2021 |
Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Me | 2014 |
In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins.
Topics: 5-Methoxypsoralen; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Citrus; Couma | 2010 |
Advances in the treatment of skin diseases.
Topics: Adrenal Cortex Hormones; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antin | 1962 |
The role of calcium, calcium-activated K+ channels, and tyrosine/kinase in psoralen-evoked responses in human melanoma cells.
Topics: Humans; Indoles; Melanoma; Methoxsalen; Photosensitizing Agents; Potassium Channels, Calcium-Activat | 2004 |
LC-MS/MS for the detection of DNA interstrand cross-links formed by 8-methoxypsoralen and UVA irradiation in human cells.
Topics: Chromatography, Liquid; DNA; DNA Adducts; DNA, Neoplasm; Humans; Melanoma; Methoxsalen; Skin Neoplas | 2008 |
Stimulation of pigmentation in melanoma cells by trimethylpsoralen in the absence of ultraviolet irradiation.
Topics: Animals; Cell Line; Darkness; Furocoumarins; Melanoma; Methoxsalen; Mice; Microscopy, Electron; Neop | 1983 |
[Cell kinetic studies on human melanoma cell line (SEKI, II) under the effect of 8-methoxypsoralen with UVA irradiation (author's transl)].
Topics: Cell Cycle; Cell Line; Humans; Melanoma; Methoxsalen; Neoplasms, Experimental; Photochemotherapy; PU | 1980 |
Sunshine and malignant melanoma.
Topics: Humans; Melanoma; Methoxsalen; Skin Neoplasms; Sunlight; Sunscreening Agents | 1980 |
PUVA treatment and choroidal malignant melanoma.
Topics: Adolescent; Choroid Neoplasms; Humans; Male; Melanoma; Methoxsalen; Psoriasis; PUVA Therapy | 1993 |
Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study.
Topics: Adult; Aged; Female; Humans; Male; Melanoma; Methoxsalen; Middle Aged; Odds Ratio; Prospective Studi | 1997 |
Cancer incidence among Finnish psoriasis patients treated with 8-methoxypsoralen bath PUVA.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Baths; Carcinoma, Basal Cell; | 1999 |
Psoralen activity and binding sites in melanotic and amelanotic human melanoma cells.
Topics: Apoptosis; Binding Sites; Binding, Competitive; Ficusin; Humans; Melanins; Melanoma; Methoxsalen; Tu | 1999 |
The risk of melanoma in association with long-term exposure to PUVA.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Incidence; Male; Melanoma; Methoxsal | 2001 |