methoxsalen has been researched along with Malignant Melanoma in 16 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 7.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| "Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis." | 7.69 | Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. ( Nichols, KT; Stern, RS; Väkevä, LH, 1997) |
| "The objectives of this study were to investigate the melanogenetic potential of the psoralen derivatives 5-hydroxypsoralen, 5-methoxypsoralen, 8-hydroxypsoralen, 8-methoxypsoralen, and 5,8-dimethoxypsoralen in B16F10 melanoma cells." | 4.12 | Mechanistic Insights into the Ameliorating Effect of Melanogenesis of Psoralen Derivatives in B16F10 Melanoma Cells. ( Hyun, CG; Lee, Y, 2022) |
| " In search of such a drug, we examined the efficacy of graveoline, a bioactive compound isolated from Ruta graveolens on skin melanoma A375 cells through the use of specific signaling cascades and their inhibitors." | 3.80 | Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. ( Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR, 2014) |
| "Oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is a highly effective therapy for psoriasis and many other skin conditions." | 3.71 | The risk of melanoma in association with long-term exposure to PUVA. ( Stern, RS, 2001) |
| "Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis." | 3.69 | Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. ( Nichols, KT; Stern, RS; Väkevä, LH, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (25.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, Y | 1 |
| Hyun, CG | 1 |
| Wróblewska-Łuczka, P | 1 |
| Grabarska, A | 1 |
| Florek-Łuszczki, M | 1 |
| Plewa, Z | 1 |
| Łuszczki, JJ | 1 |
| Ghosh, S | 1 |
| Bishayee, K | 1 |
| Khuda-Bukhsh, AR | 1 |
| Menichini, F | 2 |
| Tundis, R | 1 |
| Loizzo, MR | 1 |
| Bonesi, M | 1 |
| Provenzano, E | 1 |
| de Cindio, B | 1 |
| TOLMAN, MM | 1 |
| WILGRAM, GF | 1 |
| Isoldi, MC | 2 |
| Pereira, EA | 1 |
| Visconti, MA | 1 |
| Castrucci, AM | 2 |
| Cao, H | 1 |
| Hearst, JE | 1 |
| Corash, L | 1 |
| Wang, Y | 1 |
| Borkovic, SP | 1 |
| Alper, JC | 1 |
| McDonald, CJ | 1 |
| Shimada, S | 1 |
| Kawashima, M | 1 |
| Watanabe, S | 1 |
| Yamada, K | 1 |
| Mizoguchi, M | 1 |
| Hori, Y | 1 |
| Kukita, A | 1 |
| Epenetos, AA | 1 |
| Haciyakupoğlu, G | 1 |
| Varinli, I | 1 |
| Memişoğlu, HR | 1 |
| Varinli, S | 1 |
| Demircan, N | 1 |
| Denli, G | 1 |
| Stern, RS | 2 |
| Nichols, KT | 1 |
| Väkevä, LH | 1 |
| Hannuksela-Svahn, A | 1 |
| Pukkala, E | 1 |
| Koulu, L | 1 |
| Jansén, CT | 1 |
| Karvonen, J | 1 |
| Scarparo, AC | 1 |
| Schumacher, RI | 1 |
| Lerner, AB | 1 |
1 review available for methoxsalen and Malignant Melanoma
| Article | Year |
|---|---|
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
Topics: Adult; Female; Humans; Hydroquinones; Male; Melanoma; Melanosis; Methoxsalen; Nevus, Pigmented; Para | 1992 |
15 other studies available for methoxsalen and Malignant Melanoma
| Article | Year |
|---|---|
Mechanistic Insights into the Ameliorating Effect of Melanogenesis of Psoralen Derivatives in B16F10 Melanoma Cells.
Topics: 5-Methoxypsoralen; Animals; beta Catenin; Cell Line, Tumor; Ficusin; Furocoumarins; Melanins; Melano | 2022 |
Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Coumarins; Drug Synergism; Furocoumarins | 2021 |
Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Me | 2014 |
In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins.
Topics: 5-Methoxypsoralen; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Citrus; Couma | 2010 |
Advances in the treatment of skin diseases.
Topics: Adrenal Cortex Hormones; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antin | 1962 |
The role of calcium, calcium-activated K+ channels, and tyrosine/kinase in psoralen-evoked responses in human melanoma cells.
Topics: Humans; Indoles; Melanoma; Methoxsalen; Photosensitizing Agents; Potassium Channels, Calcium-Activat | 2004 |
LC-MS/MS for the detection of DNA interstrand cross-links formed by 8-methoxypsoralen and UVA irradiation in human cells.
Topics: Chromatography, Liquid; DNA; DNA Adducts; DNA, Neoplasm; Humans; Melanoma; Methoxsalen; Skin Neoplas | 2008 |
Stimulation of pigmentation in melanoma cells by trimethylpsoralen in the absence of ultraviolet irradiation.
Topics: Animals; Cell Line; Darkness; Furocoumarins; Melanoma; Methoxsalen; Mice; Microscopy, Electron; Neop | 1983 |
[Cell kinetic studies on human melanoma cell line (SEKI, II) under the effect of 8-methoxypsoralen with UVA irradiation (author's transl)].
Topics: Cell Cycle; Cell Line; Humans; Melanoma; Methoxsalen; Neoplasms, Experimental; Photochemotherapy; PU | 1980 |
Sunshine and malignant melanoma.
Topics: Humans; Melanoma; Methoxsalen; Skin Neoplasms; Sunlight; Sunscreening Agents | 1980 |
PUVA treatment and choroidal malignant melanoma.
Topics: Adolescent; Choroid Neoplasms; Humans; Male; Melanoma; Methoxsalen; Psoriasis; PUVA Therapy | 1993 |
Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study.
Topics: Adult; Aged; Female; Humans; Male; Melanoma; Methoxsalen; Middle Aged; Odds Ratio; Prospective Studi | 1997 |
Cancer incidence among Finnish psoriasis patients treated with 8-methoxypsoralen bath PUVA.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Baths; Carcinoma, Basal Cell; | 1999 |
Psoralen activity and binding sites in melanotic and amelanotic human melanoma cells.
Topics: Apoptosis; Binding Sites; Binding, Competitive; Ficusin; Humans; Melanins; Melanoma; Methoxsalen; Tu | 1999 |
The risk of melanoma in association with long-term exposure to PUVA.
Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; Female; Humans; Incidence; Male; Melanoma; Methoxsal | 2001 |