methoxsalen has been researched along with Lichen Planus in 6 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a saw-tooth pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-three patients with lichen planus (LP) were treated with either oral methoxsalen PUVA (10 cases), bath methoxsalen PUVA (13 cases) or no PUVA (20 cases)." | 7.67 | Long-term efficacy of PUVA treatment in lichen planus: comparison of oral and external methoxsalen regimens. ( Helander, I; Jansén, CT; Meurman, L, 1987) |
| "Forty-three patients with lichen planus (LP) were treated with either oral methoxsalen PUVA (10 cases), bath methoxsalen PUVA (13 cases) or no PUVA (20 cases)." | 3.67 | Long-term efficacy of PUVA treatment in lichen planus: comparison of oral and external methoxsalen regimens. ( Helander, I; Jansén, CT; Meurman, L, 1987) |
| " Following the dosage parameters toxic side effects were rare and reversible." | 2.36 | [Oral photochemotherapy (author's transl)]. ( Gschnait, F, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rozyeva, AA | 1 |
| von Kobyletzki, G | 1 |
| Gruss, C | 1 |
| Altmeyer, P | 1 |
| Kerscher, M | 1 |
| Ortonne, JP | 2 |
| Schmitt, D | 1 |
| Alario, A | 1 |
| Thivolet, J | 2 |
| Gschnait, F | 1 |
| Sannwald, C | 1 |
| Helander, I | 1 |
| Jansén, CT | 1 |
| Meurman, L | 1 |
1 review available for methoxsalen and Lichen Planus
| Article | Year |
|---|---|
[Oral photochemotherapy (author's transl)].
Topics: Adult; Dose-Response Relationship, Radiation; Eczema; Eye Protective Devices; Female; Humans; Hypers | 1977 |
5 other studies available for methoxsalen and Lichen Planus
| Article | Year |
|---|---|
[First experience of PUVA-therapy in lichen ruber planus].
Topics: Adult; Female; Follow-Up Studies; Furocoumarins; Humans; Lichen Planus; Male; Methoxsalen; Middle Ag | 1980 |
[Balneophotochemotherapy of lichen ruber. Personal results and comparison with photochemotherapy modalities employed up to now].
Topics: Adult; Aged; Balneology; Female; Follow-Up Studies; Humans; Lichen Planus; Male; Methoxsalen; Middle | 1997 |
Oral photochemotherapy in lichen planus (LP) and mycosis fungoides (MF): ultrastructural modifications of the infiltrating cells.
Topics: Cell Nucleus; Cytoplasm; Humans; Lichen Planus; Methoxsalen; Mycosis Fungoides; Necrosis; Photochemo | 1979 |
Oral photochemotherapy in the treatment of lichen planus (LP). Clinical results, histological and ultrastructural observations.
Topics: Adult; Aged; Child; Female; Humans; Lichen Planus; Male; Methoxsalen; Middle Aged; Photochemotherapy | 1978 |
Long-term efficacy of PUVA treatment in lichen planus: comparison of oral and external methoxsalen regimens.
Topics: Administration, Oral; Baths; Follow-Up Studies; Humans; Lichen Planus; Methoxsalen; Middle Aged; PUV | 1987 |