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methoxsalen and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

methoxsalen has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 3 studies

Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.

Research Excerpts

ExcerptRelevanceReference
"A 45-year-old male with chronic myelocytic leukemia who received a bone marrow transplantation from a phenotypically HLA-matched unrelated donor developed chronic GVHD on day 100 post transplantation."1.29A case of chronic GVHD following bone marrow transplantation from a phenotypically HLA-matched unrelated donor. ( Sano, Y; Shimao, S; Tanaka, K, 1994)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, M1
Roldan, MC1
Haskell, MK1
McAdam, SR1
Hartley, JA1
Salvador, A1
Dall'Acqua, S1
Sardo, MS1
Caffieri, S1
Vedaldi, D1
Dall'Acqua, F1
Borgatti, M1
Zuccato, C1
Bianchi, N1
Gambari, R1
Sano, Y1
Tanaka, K1
Shimao, S1

Other Studies

3 other studies available for methoxsalen and Leukemia, Myelogenous, Chronic, BCR-ABL Positive

ArticleYear
In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
    Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8

    Topics: Alkylation; Antineoplastic Agents; Base Composition; Coumarins; Cross-Linking Reagents; DNA; Ficusin

1994
Erythroid induction of chronic myelogenous leukemia K562 cells following treatment with a photoproduct derived from the UV-A irradiation of 5-methoxypsoralen.
    ChemMedChem, 2010, Sep-03, Volume: 5, Issue:9

    Topics: 5-Methoxypsoralen; Antineoplastic Agents; Cell Differentiation; Erythroid Cells; Heterocyclic Compou

2010
A case of chronic GVHD following bone marrow transplantation from a phenotypically HLA-matched unrelated donor.
    The Journal of dermatology, 1994, Volume: 21, Issue:4

    Topics: Bone Marrow Transplantation; Chronic Disease; Graft vs Host Disease; Histocompatibility; Humans; Leu

1994