Compounds > methoxsalen
Page last updated: 2024-10-31

methoxsalen and Kaposi Disease

methoxsalen has been researched along with Kaposi Disease in 12 studies

Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Research Excerpts

ExcerptRelevanceReference
"Angelicin is a congener of 8-MOP which forms only monoadducts."1.26DNA repair in human cells containing photoadducts of 8-methoxypsoralen or angelicin. ( Hanawalt, PC; Kaye, J; Smith, CA, 1980)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19907 (58.33)18.7374
1990's4 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, S1
Wang, Y1
EL-HEFNAWI, H1
MORTADA, A1
Bredberg, A2
Lambert, B1
Söderhäll, S2
Kaye, J1
Smith, CA1
Hanawalt, PC2
Payne, A1
Chu, G1
Matsumoto, A1
Fujiwara, Y1
Elespuru, RK1
Sun, Y1
Moses, RE1
Parrish, DD1
Lambert, MW1
Gruenert, DC1
Kapp, LN1
Cleaver, JE1
Baden, HP1
Parrington, JM1
Delhanty, JD1
Pathak, MA1
Noojin, RO1

Other Studies

12 other studies available for methoxsalen and Kaposi Disease

ArticleYear
A quantitative mass spectrometry-based approach for assessing the repair of 8-methoxypsoralen-induced DNA interstrand cross-links and monoadducts in mammalian cells.
    Analytical chemistry, 2013, Jul-16, Volume: 85, Issue:14

    Topics: Animals; Cells, Cultured; CHO Cells; Chromatography, Liquid; Cricetinae; Cricetulus; Cross-Linking R

2013
OCULAR MANIFESTATIONS OF XERODERMA PIGMENTOSUM.
    The British journal of dermatology, 1965, Volume: 77

    Topics: Adolescent; Child; Consanguinity; Diathermy; Drug Therapy; Egypt; Eye; Eye Manifestations; Eye Neopl

1965
Induction and repair of psoralen cross-links in DNA of normal human and xeroderma pigmentosum fibroblasts.
    Mutation research, 1982, Volume: 93, Issue:1

    Topics: Cell Line; DNA Repair; DNA Replication; Fibroblasts; Humans; Methoxsalen; Skin; Ultraviolet Rays; Xe

1982
DNA repair in human cells containing photoadducts of 8-methoxypsoralen or angelicin.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Cells, Cultured; Cross-Linking Reagents; DNA Repair; Furocoumarins; Humans; Intercalating Agents; Me

1980
Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage.
    Mutation research, 1994, Oct-01, Volume: 310, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Cisplatin; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Genetic Comp

1994
Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and dihydrofolate reductase.
    Photochemistry and photobiology, 1994, Volume: 60, Issue:3

    Topics: Aminoglycosides; Anti-Bacterial Agents; Blotting, Southern; Cell Line; Cell Survival; Coumarins; DNA

1994
Reactivation of psoralen-reacted plasmid DNA in Fanconi anemia, xeroderma pigmentosum, and normal human fibroblast cells.
    Somatic cell and molecular genetics, 1991, Volume: 17, Issue:3

    Topics: Cell Line, Transformed; Cell Survival; Chloramphenicol O-Acetyltransferase; Cross-Linking Reagents;

1991
Chromatin-associated DNA endonucleases from xeroderma pigmentosum cells are defective in interaction with damaged nucleosomal DNA.
    Mutation research, 1990, Volume: 235, Issue:2

    Topics: Cell Line; Chromatin; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Furocoumarins; Histones;

1990
Normal rate of DNA breakage in xeroderma pigmentosum complementation group E cells treated with 8-methoxypsoralen plus near-ultraviolet radiation.
    Biochimica et biophysica acta, 1985, Mar-20, Volume: 824, Issue:3

    Topics: DNA; Fibroblasts; Humans; In Vitro Techniques; Methoxsalen; Skin; Ultraviolet Rays; Xeroderma Pigmen

1985
Inhibition of DNA synthesis by psoralen-induced lesions in xeroderma pigmentosum and Fanconi's anemia fibroblasts.
    Photochemistry and photobiology, 1985, Volume: 41, Issue:5

    Topics: Anemia, Aplastic; Cell Line; DNA Replication; Fanconi Anemia; Humans; Methoxsalen; Ultraviolet Rays;

1985
DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.
    Biochimica et biophysica acta, 1972, Mar-24, Volume: 262, Issue:3

    Topics: Adult; Animals; Autoradiography; Cell Survival; Child; DNA; DNA Repair; Female; Fibroblasts; Guinea

1972
Xeroderma pigmentosum treated with oral methoxsalen.
    Archives of dermatology, 1965, Volume: 92, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Methoxsalen; Xeroderma Pigmentos

1965