methoxsalen has been researched along with Graft-Versus-Host Disease in 29 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In serum, peak 8-MOP concentrations were reached < or =40 min following ingestion; the half-life of 8-MOP in the serum was 50+/-14 min (n=7)." | 1.30 | Pharmacokinetics of 8-methoxypsoralen during extracorporeal photopheresis. ( Nestle, FO; Panizzon, R; Shephard, SE, 1999) |
| "A 45-year-old male with chronic myelocytic leukemia who received a bone marrow transplantation from a phenotypically HLA-matched unrelated donor developed chronic GVHD on day 100 post transplantation." | 1.29 | A case of chronic GVHD following bone marrow transplantation from a phenotypically HLA-matched unrelated donor. ( Sano, Y; Shimao, S; Tanaka, K, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| Buder, K | 2 |
| Zirngibl, M | 2 |
| Bapistella, S | 2 |
| Meerpohl, JJ | 2 |
| Strahm, B | 2 |
| Bassler, D | 2 |
| Weitz, M | 2 |
| Alsuliman, T | 1 |
| Magro, L | 1 |
| Coiteux, V | 1 |
| Gauthier, J | 1 |
| Srour, M | 1 |
| Lionet, A | 1 |
| Beauvais, D | 1 |
| Yakoub-Agha, I | 1 |
| Hähnel, V | 1 |
| Brosig, AM | 1 |
| Ehrenschwender, M | 1 |
| Burkhardt, R | 1 |
| Offner, R | 1 |
| Ahrens, N | 1 |
| Holien, T | 1 |
| Gederaas, OA | 1 |
| Darvekar, SR | 1 |
| Christensen, E | 1 |
| Peng, Q | 1 |
| Budde, H | 1 |
| Papert, S | 1 |
| Reichardt, HM | 1 |
| Jarry, H | 1 |
| Riggert, J | 1 |
| Legler, TJ | 1 |
| Coppard, C | 1 |
| Hannani, D | 1 |
| Humbert, M | 1 |
| Gauthier, V | 1 |
| Plumas, J | 1 |
| Merlin, E | 1 |
| Gabert, F | 1 |
| Chaperot, L | 1 |
| Jagasia, M | 1 |
| Scheid, C | 1 |
| Socié, G | 1 |
| Ayuk, FA | 1 |
| Tischer, J | 1 |
| Donato, ML | 1 |
| Bátai, Á | 1 |
| Chen, H | 1 |
| Chen, SC | 1 |
| Chin, T | 1 |
| Boodée, H | 1 |
| Mitri, G | 1 |
| Greinix, HT | 2 |
| Bojanic, I | 1 |
| Serventi Seiwerth, R | 1 |
| Golubic Cepulic, B | 1 |
| Mazic, S | 1 |
| Lukic, M | 1 |
| Raos, M | 1 |
| Plenkovic, F | 1 |
| Golemovic, M | 1 |
| Dubravcic, K | 1 |
| Perkovic, S | 1 |
| Batinic, D | 1 |
| Labar, B | 1 |
| Heshmati, F | 2 |
| Taverna, F | 1 |
| Coluccia, P | 1 |
| Arienti, F | 1 |
| Birolini, A | 1 |
| Terranova, L | 1 |
| Mazzocchi, A | 1 |
| Rini, F | 1 |
| Mariani, L | 1 |
| Melani, C | 1 |
| Ravagnani, F | 1 |
| Feldreich, N | 1 |
| Ringden, O | 1 |
| Emtestam, L | 1 |
| Omazic, B | 1 |
| Di Biaso, I | 1 |
| Di Maio, L | 1 |
| Bugarin, C | 1 |
| Gaipa, G | 1 |
| Dander, E | 1 |
| Balduzzi, A | 1 |
| Parma, M | 1 |
| D'Amico, G | 1 |
| Perseghin, P | 1 |
| Biondi, A | 1 |
| Biagi, E | 1 |
| Perotti, C | 1 |
| Del Fante, C | 1 |
| Tinelli, C | 1 |
| Viarengo, G | 1 |
| Scudeller, L | 1 |
| Zecca, M | 1 |
| Locatelli, F | 1 |
| Salvaneschi, L | 1 |
| Capitini, CM | 1 |
| Davis, JP | 1 |
| Larabee, SM | 1 |
| Herby, S | 1 |
| Nasholm, NM | 1 |
| Fry, TJ | 1 |
| Kofoed, K | 1 |
| Schiødt, I | 1 |
| Gniadecki, R | 1 |
| Daniele, N | 1 |
| Del Proposto, G | 1 |
| Cerrone, P | 1 |
| Sinopoli, S | 1 |
| Sansone, L | 1 |
| Gadaleta, DI | 1 |
| Lanti, A | 1 |
| Ferraro, AS | 1 |
| Spurio, S | 1 |
| Scerpa, MC | 1 |
| Zinno, F | 1 |
| Adorno, G | 1 |
| Isacchi, G | 1 |
| Trautinger, F | 1 |
| Just, U | 1 |
| Knobler, R | 1 |
| Mabed, M | 1 |
| Coffe, C | 1 |
| Racadot, E | 1 |
| Angonin, R | 1 |
| Pavey, JJ | 1 |
| Tiberghien, P | 1 |
| Herve, P | 1 |
| Peritt, D | 1 |
| Sano, Y | 1 |
| Tanaka, K | 1 |
| Shimao, S | 1 |
| Grass, JA | 1 |
| Hei, DJ | 1 |
| Metchette, K | 1 |
| Cimino, GD | 1 |
| Wiesehahn, GP | 1 |
| Corash, L | 1 |
| Lin, L | 1 |
| Nishimura, M | 1 |
| Akaza, T | 1 |
| Tadokoro, K | 1 |
| Juji, T | 1 |
| Zic, JA | 1 |
| Miller, JL | 1 |
| Stricklin, GP | 1 |
| King, LE | 1 |
| Shephard, SE | 1 |
| Nestle, FO | 1 |
| Panizzon, R | 1 |
| Volc-Platzer, B | 1 |
| Kalhs, P | 1 |
| Fischer, G | 1 |
| Rosenmayr, A | 1 |
| Keil, F | 1 |
| Hönigsmann, H | 1 |
| Knobler, RM | 1 |
| Eppinger, T | 1 |
| Ehninger, G | 2 |
| Steinert, M | 2 |
| Niethammer, D | 1 |
| Dopfer, R | 2 |
| Jaschonek, K | 1 |
| Einsele, H | 1 |
| Schmidt, H | 1 |
| Lenz, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Study of Extracorporeal Photopheresis (ECP) Therapy With UVADEX for the Treatment of Patients With Moderate to Severe Chronic Graft-versus-Host Disease (cGvHD)[NCT01380535] | Early Phase 1 | 60 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Impact of Photopheresis in the Prevention of Acute Rejection in Highly Sensitized de Novo Kidney Transplant Recipients[NCT04414735] | 30 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants with overall response included those with partial response or complete response, according to study staff who did not know which treatment they received (blinded assessment). (NCT01380535)
Timeframe: Week 28
| Intervention | Participants (Count of Participants) |
|---|---|
| ECP Methoxsalen + SoC | 20 |
| Standard of Care (SoC) | 14 |
8 reviews available for methoxsalen and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Extracorporeal photopheresis versus alternative treatment for chronic graft-versus-host disease after haematopoietic stem cell transplantation in children and adolescents.
Topics: Adolescent; Child; Chronic Disease; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; | 2022 |
Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in children and adolescents.
Topics: Adolescent; Adrenal Cortex Hormones; Child; Graft vs Host Disease; Hematopoietic Stem Cell Transplan | 2022 |
Updating ECP action mechanisms.
Topics: Apoptosis; Dendritic Cells; Graft Rejection; Graft vs Host Disease; Humans; Immunity, Cellular; Inte | 2014 |
[Documented effect of extra corporeal photopheresis on T-cell mediated diseases].
Topics: Evidence-Based Medicine; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Ph | 2011 |
Photopheresis (extracorporeal photochemotherapy).
Topics: Graft Rejection; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photophere | 2013 |
Mechanisms of action of extracorporeal photochemotherapy.
Topics: Apoptosis; CD4-Positive T-Lymphocytes; CD40 Antigens; CD8-Positive T-Lymphocytes; Cell Membrane; Cro | 2003 |
Potential mechanisms of photopheresis in hematopoietic stem cell transplantation.
Topics: Antigen Presentation; Antigen-Presenting Cells; Apoptosis; CD8-Positive T-Lymphocytes; Cytokines; Gr | 2006 |
The North American experience with photopheresis.
Topics: Arthritis, Rheumatoid; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Nort | 1999 |
4 trials available for methoxsalen and Graft-Versus-Host Disease
| Article | Year |
|---|---|
Randomized controlled study of ECP with methoxsalen as first-line treatment of patients with moderate to severe cGVHD.
Topics: Adult; Aged; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; M | 2019 |
Treatment of chronic GVHD with extracorporeal photochemotherapy.
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Female; Graft vs Host Disease; Humans; Leukapheresi | 2013 |
Evaluation of cell death after treatment with extracorporeal photopheresis.
Topics: Adult; Apoptosis; Female; Graft vs Host Disease; Humans; Leukocytes; Male; Methoxsalen; Middle Aged; | 2012 |
Potential usefulness of photochemotherapy using 8-methoxypsoralen in the treatment of posttransfusion graft-versus-host disease.
Topics: Graft vs Host Disease; Humans; Japan; Methoxsalen; Photochemotherapy; Photosensitizing Agents; Trans | 1998 |
17 other studies available for methoxsalen and Graft-Versus-Host Disease
| Article | Year |
|---|---|
The concurrent administration of imatinib with extracorporeal photopheresis leads to complete and durable responses in patients with refractory sclerotic type chronic graft-versus-host disease.
Topics: Adrenal Cortex Hormones; Adult; Chronic Disease; Combined Modality Therapy; Drug Resistance; Female; | 2020 |
Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8-methoxypsoralen concentration and by replacing plasma with saline.
Topics: Adult; Aged; Apoptosis; Female; Graft vs Host Disease; Humans; Lymphocytes; Male; Methoxsalen; Middl | 2021 |
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
Topics: Aminolevulinic Acid; Cell Culture Techniques; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutan | 2018 |
An alternative for extracorporeal photopheresis: 8-methoxypsoralen and UVA-treated leucocytes from allogeneic donors improve graft-versus-host disease in mice.
Topics: Allogeneic Cells; Animals; Graft vs Host Disease; Humans; Leukocytes; Male; Methoxsalen; Mice; Mice, | 2018 |
In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis.
Topics: Apoptosis; Calreticulin; Cells, Cultured; Dendritic Cells; Graft vs Host Disease; HMGB1 Protein; Hum | 2019 |
Biological quality control for extracorporeal photochemotherapy: Assessing mononuclear cell apoptosis levels in ECP bags of chronic GvHD patients.
Topics: Adult; Aged; Apoptosis; Blood Component Removal; Cell Proliferation; Cell Separation; Female; Flow C | 2015 |
Photochemotherapy of Cutaneous Graft-versus-Host Disease May Reduce Concomitant Visceral Disease.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Stud | 2016 |
Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells.
Topics: Graft vs Host Disease; Humans; Inflammation; Methoxsalen; Photopheresis; T-Lymphocytes; T-Lymphocyte | 2009 |
Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Chronic Disease; Disease-Free Survival; Female; | 2010 |
Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination.
Topics: Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniq | 2011 |
Differential sensitivity of T lymphocytes and hematopoietic precursor cells to photochemotherapy with 8-methoxypsoralen and ultraviolet A light.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Dose-Response Relationship, Radiation; Graft | 2006 |
A case of chronic GVHD following bone marrow transplantation from a phenotypically HLA-matched unrelated donor.
Topics: Bone Marrow Transplantation; Chronic Disease; Graft vs Host Disease; Histocompatibility; Humans; Leu | 1994 |
Inactivation of leukocytes in platelet concentrates by photochemical treatment with psoralen plus UVA.
Topics: Adult; DNA Adducts; DNA Damage; Gamma Rays; Graft vs Host Disease; Humans; Interleukin-8; Leukocyte | 1998 |
Pharmacokinetics of 8-methoxypsoralen during extracorporeal photopheresis.
Topics: Adult; Aged; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationsh | 1999 |
Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study.
Topics: Acute Disease; Adult; Biopsy; Drug Resistance; Female; Gastrointestinal Hemorrhage; Graft vs Host Di | 2000 |
8-Methoxypsoralen and ultraviolet A therapy for cutaneous manifestations of graft-versus-host disease.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Female; Graft vs Host Disease; Humans; Male; | 1990 |
8-Methoxypsoralen and ultraviolet A therapy for cutaneous manifestations of graft-versus-host disease.
Topics: Graft vs Host Disease; Humans; Methoxsalen; PUVA Therapy; Skin Diseases | 1988 |