methoxsalen has been researched along with Germinoblastoma in 11 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mycosis fungoides is a cutaneously-derived malignant lymphoma which, without effective treatment, may run an unrelenting, rapidly lethal course." | 1.26 | Mycosis fungoides: clinical and therapeutic review. ( Basler, RS; Lynch, PJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu-Lee, VW | 1 |
| Heddle, JA | 2 |
| Arlett, CF | 2 |
| Broughton, B | 1 |
| Kraemer, KH | 1 |
| Broughton, BC | 1 |
| Rogers, AM | 1 |
| Chételat, AA | 1 |
| Albertini, S | 1 |
| Gocke, E | 1 |
| Hofmann, C | 1 |
| Burg, G | 1 |
| Plewig, G | 2 |
| Braun-Falco, O | 1 |
| Konrad, K | 1 |
| Gschnait, F | 1 |
| Hönigsmann, H | 1 |
| Fritsch, P | 1 |
| Wolff, K | 2 |
| Basler, RS | 1 |
| Lynch, PJ | 1 |
| Edelson, RL | 1 |
| Santella, RM | 1 |
| Yang, XY | 1 |
| DeLeo, VA | 1 |
| Gasparro, FP | 1 |
| Knobler, RM | 1 |
| Edelson, R | 1 |
| Berger, C | 1 |
| Gasparro, F | 1 |
| Jegasothy, B | 1 |
| Heald, P | 1 |
| Wintroub, B | 1 |
| Vonderheid, E | 1 |
| Knobler, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single Arm Study of Extracorporeal Photoimmune Therapy With Uvadex For Corticosteroid Sparing in Patients With Corticosteroid-Dependent Crohn's Disease Who May Also Be Refractory or Intolerant to Immunosuppressants and/or Anti-Tumor Necrosis Factor Agen[NCT00056355] | Phase 1 | 10 participants | Interventional | 2003-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for methoxsalen and Germinoblastoma
| Article | Year |
|---|---|
[Photochemotherapy of cutaneous lymphoma: oral and local 8-MOP-UVA treatment (author's transl)].
Topics: Aged; Dermatitis, Exfoliative; Female; Humans; Keratoderma, Palmoplantar; Lymphatic Diseases; Lympho | 1977 |
Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Female; Humans; Lymphoma; Male; Methoxs | 1987 |
9 other studies available for methoxsalen and Germinoblastoma
| Article | Year |
|---|---|
Genetic effects of specific DNA lesions in mammalian cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromosome Aberrations; Cross-Linking Reagents; Crossing Ove | 1984 |
In vitro assay of the effects of psoralens plus ultraviolet radiation on human lymphoid cells.
Topics: Cell Survival; DNA; DNA Replication; Furocoumarins; Histocompatibility Testing; Humans; In Vitro Tec | 1982 |
Cell killing and mutagenesis by 8-methoxypsoralen in mammalian (rodent) cells.
Topics: Animals; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Rela | 1980 |
The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay).
Topics: Animals; Anti-Infective Agents; Carcinogens; Chromosome Aberrations; Ciprofloxacin; Cricetinae; DNA | 1996 |
[Photochemotherapy in mycosis fungoides].
Topics: Adult; Aged; Female; Humans; Lymphoma; Male; Methoxsalen; Middle Aged; Mycosis Fungoides; Photochemo | 1978 |
Mycosis fungoides: clinical and therapeutic review.
Topics: Humans; Lymphoma; Mechlorethamine; Methoxsalen; Mycosis Fungoides; Photochemotherapy; Sezary Syndrom | 1979 |
Photopheresis.
Topics: Animals; Blood; Blood Component Removal; Drug Carriers; Humans; Liposomes; Lymphoma; Methoxsalen; Mi | 1990 |
Detection and quantification of 8-methoxypsoralen-DNA adducts.
Topics: Animals; DNA; Flow Cytometry; Fluorescent Antibody Technique; Humans; Lymphoma; Methoxsalen; Mice; P | 1988 |
Photopheresis--extracorporeal irradiation of 8-MOP containing blood--a new therapeutic modality.
Topics: Combined Modality Therapy; Extracorporeal Circulation; Humans; Lymphoma; Methoxsalen; Plasmapheresis | 1987 |