methoxsalen has been researched along with Disease Models, Animal in 26 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of 8-Methoxypsoralen plus ultraviolet A (PUVA) or ultraviolet B (UVB) alone on imiquimod-induced psoriasis were examined in a mouse model." | 3.88 | 8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model. ( Brüne, B; Kenner, L; Ringel, C; Schlederer, M; Shirsath, N; Tangermann, S; Wagner, K; Wolf, P, 2018) |
| "The rats' brain edema was assessed by the dry and wet method, and neuronal apoptosis in damaged brain tissues was monitored by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) and Nissl's staining." | 1.91 | Traumatic Brain Injury-Mediated Neuroinflammation and Neurological Deficits are Improved by 8-Methoxypsoralen Through Modulating PPARγ/NF-κB Pathway. ( Hui, Y; Shi, L; Zhang, H; Zhao, H, 2023) |
| " However, psoralens safety for long-term use is a concern." | 1.46 | 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. ( Jiang, Z; Li, Z; Wang, T; Xu, D; Yin, M; Yuan, Z; Zhang, L; Zhao, G; Zhou, W; Zhou, Z, 2017) |
| "In vivo phototoxicity studies are important to predict drug-induced phototoxicity in humans; however, a standard methodology has not established." | 1.46 | The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity. ( Harada, Y; Kuga, K; Miyamoto, M; Miyamoto, Y; Sakai, Y; Sato, K; Shimizu, F; Takamatsu, Y; Yasuno, H, 2017) |
| "The nicotine plasma levels were also measured with or without methoxsalen pretreatment." | 1.40 | Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. ( Bagdas, D; Damaj, MI; Muldoon, PP; Tyndale, RF; Zhu, AZ, 2014) |
| "It concerns the Wistar-derived rat with contact hypersensitivity (CHS), also a T cell mediated disorder that has already been studied extensively in several other fields of research." | 1.28 | An animal model for extracorporeal photochemotherapy based on contact hypersensitivity. ( Beijersbergen van Henegouwen, GM; van Iperen, HP, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 12 (46.15) | 24.3611 |
| 2020's | 5 (19.23) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hui, Y | 1 |
| Zhao, H | 1 |
| Shi, L | 1 |
| Zhang, H | 1 |
| Ham, JR | 1 |
| Choi, RY | 1 |
| Lee, HI | 1 |
| Lee, MK | 1 |
| Hindam, MO | 1 |
| Sayed, RH | 1 |
| Skalicka-Woźniak, K | 2 |
| Budzyńska, B | 2 |
| El Sayed, NS | 1 |
| Maciąg, M | 1 |
| Michalak, A | 1 |
| Zykubek, M | 1 |
| Ciszewski, A | 1 |
| Zhao, G | 1 |
| Xu, D | 1 |
| Yuan, Z | 1 |
| Jiang, Z | 1 |
| Zhou, W | 2 |
| Li, Z | 1 |
| Yin, M | 1 |
| Zhou, Z | 1 |
| Zhang, L | 2 |
| Wang, T | 1 |
| Kuga, K | 1 |
| Yasuno, H | 1 |
| Sakai, Y | 1 |
| Harada, Y | 1 |
| Shimizu, F | 1 |
| Miyamoto, Y | 1 |
| Takamatsu, Y | 1 |
| Miyamoto, M | 1 |
| Sato, K | 1 |
| Yang, Y | 1 |
| Zheng, K | 1 |
| Mei, W | 1 |
| Wang, Y | 1 |
| Yu, C | 1 |
| Yu, B | 1 |
| Deng, S | 1 |
| Hu, J | 1 |
| Shirsath, N | 1 |
| Wagner, K | 1 |
| Tangermann, S | 1 |
| Schlederer, M | 1 |
| Ringel, C | 1 |
| Kenner, L | 1 |
| Brüne, B | 1 |
| Wolf, P | 3 |
| Liu, C | 1 |
| Zhong, L | 1 |
| Tian, XL | 1 |
| Han, YC | 1 |
| Bagdas, D | 1 |
| Muldoon, PP | 1 |
| Zhu, AZ | 1 |
| Tyndale, RF | 1 |
| Damaj, MI | 1 |
| Wei, Y | 1 |
| Zheng, D | 1 |
| Li, X | 1 |
| Qian, Y | 1 |
| Ming, C | 1 |
| Shi, B | 1 |
| Li, XJ | 1 |
| Zhu, Z | 1 |
| Han, SL | 1 |
| Zhang, ZL | 1 |
| Singh, TP | 2 |
| Schön, MP | 2 |
| Wallbrecht, K | 2 |
| Michaelis, K | 1 |
| Rinner, B | 1 |
| Mayer, G | 1 |
| Schmidbauer, U | 1 |
| Strohmaier, H | 1 |
| Wang, XJ | 1 |
| Hayashi, S | 1 |
| Ikeda, M | 1 |
| Kitamura, Y | 1 |
| Hamasaki, Y | 1 |
| Hatamochi, A | 1 |
| Liu, WX | 1 |
| Jia, FL | 1 |
| He, YY | 1 |
| Zhang, BX | 1 |
| Miyauchi-Hashimoto, H | 1 |
| Okamoto, H | 1 |
| Sugihara, A | 1 |
| Horio, T | 1 |
| Liang, H | 1 |
| Li, J | 1 |
| van Iperen, HP | 2 |
| Beijersbergen van Henegouwen, GM | 2 |
| Akin, FJ | 1 |
| Rose, AP | 1 |
| Chamness, TW | 1 |
| Marlowe, E | 1 |
| Fritsch, PO | 1 |
| Gschnait, F | 1 |
| Kaaserer, G | 1 |
| Brenner, W | 1 |
| Chaikittisilpa, S | 1 |
| Hönigsmann, H | 1 |
| Wolff, K | 1 |
| Oill, PA | 1 |
| Galpin, JE | 1 |
| Fox, MA | 1 |
| Guze, LB | 1 |
| Young, AR | 1 |
| Walker, SL | 1 |
| Kinley, JS | 1 |
| Plastow, SR | 1 |
| Averbeck, D | 1 |
| Morlière, P | 1 |
| Dubertret, L | 1 |
| Bay, WW | 1 |
| Gleiser, CA | 1 |
| Dukes, TW | 1 |
| Brown, RS | 1 |
26 other studies available for methoxsalen and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Traumatic Brain Injury-Mediated Neuroinflammation and Neurological Deficits are Improved by 8-Methoxypsoralen Through Modulating PPARγ/NF-κB Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; L | 2023 |
Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-Induced Osteopenia and Steatosis in Rats.
Topics: Alcoholism; Animals; Biomarkers; Bone and Bones; Bone Diseases, Metabolic; Cytokines; Dietary Supple | 2020 |
Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Disease Models, Animal; Male; Methoxsalen; NF-E2- | 2020 |
Zebrafish and mouse models for anxiety evaluation - A comparative study with xanthotoxin as a model compound.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Male; Methoxsalen; | 2020 |
8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Bile Acids and Salts; Cell Line; Chemical an | 2017 |
The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity.
Topics: Abdomen; Administration, Oral; Animals; Back; Dermatitis, Phototoxic; Disease Models, Animal; Doxycy | 2017 |
Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model.
Topics: 5-Methoxypsoralen; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Female; Ficus; Inflamm | 2018 |
8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model.
Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Imi | 2018 |
Protective effects of 8-MOP on blood-brain barrier via the Nrf-2/HO-1 pathway in mice model of cerebral infarction.
Topics: Animals; Blood-Brain Barrier; Cerebral Infarction; Disease Models, Animal; Endothelial Cells; Heme O | 2018 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family | 2014 |
Infusion of dendritic cells carrying donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light induces CD19+ IL-10+ regulatory B cells and promotes skin allograft survival.
Topics: Allografts; Animals; Antigens, CD19; B-Lymphocytes, Regulatory; Cell Differentiation; Dendritic Cell | 2014 |
Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice.
Topics: 5-Methoxypsoralen; Animals; Anti-Inflammatory Agents; Biomarkers; Diabetes Complications; Disease Mo | 2016 |
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.
Topics: Animals; Antigens, CD; Cell Separation; CTLA-4 Antigen; Disease Models, Animal; Enzyme-Linked Immuno | 2010 |
8-Methoxypsoralen plus UVA treatment increases the proportion of CLA+ CD25+ CD4+ T cells in lymph nodes of K5.hTGFβ1 transgenic mice.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Disease Models, Animal; Interleukin-2 Receptor alp | 2012 |
UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin.
Topics: Administration, Cutaneous; Animals; Bleomycin; Collagen Type I; Collagen Type III; Disease Models, A | 2012 |
Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice.
Topics: 5-Methoxypsoralen; Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Antioxidants; | 2012 |
Therapeutic and prophylactic effects of PUVA photochemotherapy on atopic dermatitis-like lesions in NC/Nga mice.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Injections, Intraperitoneal; Male; Methoxsalen; | 2005 |
Establishment of mus skin photo-damage model by 8-MOP plus UVA irradiation.
Topics: Animals; Dermis; Disease Models, Animal; Epidermis; Female; Male; Methoxsalen; Mice; Photosensitizin | 2007 |
An animal model and new photosensitizers for photopheresis.
Topics: Animals; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Male; Methoxsalen; Photo | 1993 |
Sunscreen protection against drug-induced phototoxicity in animal models.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Chlorpromazine; Demeclocycline; Disease Models, Animal | 1979 |
PUVA suppresses the proliferative stimulus produced by stripping on hairless mice.
Topics: Animals; Autoradiography; Disease Models, Animal; DNA; Furocoumarins; Methoxsalen; Mice; Mice, Nude; | 1979 |
Treatment of cutaneous Herpesvirus hominis type 2 infection with 8-methoxypsoralen and long-wave ultraviolet light in guinea pigs.
Topics: Animals; Disease Models, Animal; Guinea Pigs; Herpes Simplex; Methoxsalen; Photochemotherapy; Skin D | 1978 |
An animal model for extracorporeal photochemotherapy based on contact hypersensitivity.
Topics: Acetone; Allergens; Animals; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Immu | 1992 |
Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model.
Topics: 5-Methoxypsoralen; Animals; Carcinogens; Disease Models, Animal; Female; Humans; Methoxsalen; Mice; | 1990 |
The experimental production and evaluation of drug-induced phototoxicity in swine.
Topics: Administration, Oral; Animals; Disease Models, Animal; Injections, Intramuscular; Injections, Intrap | 1970 |