methoxsalen has been researched along with Dermatitis, Contact, Phototoxic in 52 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient developed severe bullous phototoxic contact dermatitis caused by Ruta graveolens L." | 2.40 | [Bullous phototoxic contact dermatitis caused by Ruta graveolens L. (garden rue), Rutaceae. Case report and review of literature]. ( Schempp, CM; Schöpf, E; Simon, JC, 1999) |
| "These data using in vitro 3T3 NRU Phototoxicity Test (OECD 432) are supportive of earlier studies showing bergamottin does not exhibit phototoxicological properties." | 1.72 | Absence of phototoxicity/photoirritation potential of bergamottin determined In Vitro using OECD TG 432. ( Cluzel, M; Hais, G; Irizar, A; Lenouvel, V; Nash, JF; Penichot, C; Sauvage, C; Vey, M; Wolf, N, 2022) |
| "This study aimed to verify the applicability of a proposed photosafety screening system based on a reactive oxygen species (ROS) assay and a cassette-dosing pharmacokinetic (PK) study to chemicals with wide structural diversity." | 1.51 | Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk. ( Iyama, Y; Onoue, S; Sato, H; Seto, Y, 2019) |
| "Previously, we showed that phototoxicity assessments in Sprague-Dawley (SD) rats can detect phototoxic potential to the same degree as those in guinea pigs." | 1.46 | Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats. ( Ashizawa, H; Hashimoto, K; Miyashita, T; Nejishima, H; Ogawa, H; Yonezawa, Y, 2017) |
| "In vivo phototoxicity studies are important to predict drug-induced phototoxicity in humans; however, a standard methodology has not established." | 1.46 | The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity. ( Harada, Y; Kuga, K; Miyamoto, M; Miyamoto, Y; Sakai, Y; Sato, K; Shimizu, F; Takamatsu, Y; Yasuno, H, 2017) |
| " In the oral administration study, both known phototoxic compounds and 5 drugs induced phototoxic reactions in both species; one compound each was found to be toxic only in SD rats or guinea pigs." | 1.42 | Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration. ( Hashimoto, K; Kataoka, A; Miyashita, T; Nejishima, H; Ogawa, H; Ohsumi, T; Yonezawa, Y, 2015) |
| " Seventy-two hours after UVA exposure minimal phototoxic doses (MPD) were defined visually and the intensity of the erythema response was also assessed by using a narrowband spectrophotometer The MPD and the dose-response curves for erythema response of the gels and creams were compared with those of the bath." | 1.33 | Phototoxicity of new psoralen-containing gels and creams versus bath PUVA. ( Leenutaphong, V; Nimkulrat, P; Sudtim, S, 2005) |
| "In such conditions, the phototoxicity assay is much more sensitive, so that the model is expected to be of great interest for the detection not only of strong but also of weak phototoxic compounds." | 1.31 | Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis. ( Barrault, C; Bernard, FX; De Wever, B; Deguercy, A; Rosdy, M, 2000) |
| "Phototoxicity is the most significant short-term adverse effect of PUVA therapy." | 1.30 | PUVA-induced phototoxicity: incidence and causes. ( Beck, L; Marwaha, S; Morison, WL, 1997) |
| "Histopathology revealed skin phototoxicity of compounds which lacked erythemogenic activity by visual scoring." | 1.30 | Antiproliferative activity and phototoxicity of some methyl derivatives of 5-methoxypsoralen and 5-methoxyangelicin. ( Conconi, MT; Montesi, F; Parnigotto, PP, 1998) |
| "The photogenotoxicity of this suction blister fluid containing 5-methoxypsoralen and also other ingredients of the tanning preparation was assayed on yeast cells and was found to be rather low." | 1.29 | Evaluation of phototoxic and photogenotoxic risk associated with the use of photosensitizers in suntan preparations: application to tanning preparations containing bergamot oil. ( Averbeck, D; Dubertret, L; Morlière, P; Moysan, A, 1993) |
| "6 mg/kg) suggests that conventional psoralen dosing according to body weight is not ideal." | 1.29 | Improved prediction of the minimal phototoxic dose in PUVA therapy. ( Farr, PM; Matthews, JN; Sakuntabhai, A, 1994) |
| "Important aspects of performing phototoxicity testing are discussed." | 1.29 | A standard protocol for phototoxicity testing. Results from an interlaboratory study. ( Maurer, T; Nilsson, R; Redmond, N, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (21.15) | 18.7374 |
| 1990's | 24 (46.15) | 18.2507 |
| 2000's | 8 (15.38) | 29.6817 |
| 2010's | 7 (13.46) | 24.3611 |
| 2020's | 2 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Atwal, SK | 1 |
| Chen, A | 1 |
| Adler, BL | 1 |
| Cluzel, M | 1 |
| Hais, G | 1 |
| Irizar, A | 1 |
| Lenouvel, V | 1 |
| Nash, JF | 1 |
| Penichot, C | 1 |
| Sauvage, C | 1 |
| Vey, M | 1 |
| Wolf, N | 1 |
| Yonezawa, Y | 2 |
| Miyashita, T | 2 |
| Ashizawa, H | 1 |
| Hashimoto, K | 2 |
| Nejishima, H | 2 |
| Ogawa, H | 2 |
| Kuga, K | 1 |
| Yasuno, H | 1 |
| Sakai, Y | 1 |
| Harada, Y | 1 |
| Shimizu, F | 1 |
| Miyamoto, Y | 1 |
| Takamatsu, Y | 1 |
| Miyamoto, M | 1 |
| Sato, K | 1 |
| Turnock, S | 1 |
| Gerbeix, C | 1 |
| Thirion-Delalande, C | 1 |
| Pearson, N | 1 |
| Forster, R | 1 |
| Iyama, Y | 1 |
| Sato, H | 1 |
| Seto, Y | 1 |
| Onoue, S | 1 |
| Al-Ismail, D | 1 |
| Edwards, C | 1 |
| Anstey, AV | 1 |
| Ohsumi, T | 1 |
| Kataoka, A | 1 |
| Toyooka, T | 1 |
| Ishihama, M | 1 |
| Ibuki, Y | 1 |
| CLARK, JH | 1 |
| HAKIM, RE | 1 |
| GRIFFIN, AC | 1 |
| KNOX, JM | 2 |
| PATHAK, MA | 2 |
| FOWLKS, WL | 1 |
| FREEMAN, RG | 1 |
| CLOUD, TM | 1 |
| MEYERZUMBUESCHENFELDE, KH | 1 |
| WULF, K | 1 |
| OGURA, R | 1 |
| HARBER, LC | 1 |
| BAER, RL | 1 |
| DANIELS, F | 1 |
| SCHENCK, RR | 1 |
| Zhang, HW | 1 |
| Dong, SX | 1 |
| Marrot, L | 1 |
| Labarussiat, A | 1 |
| Perez, P | 1 |
| Meunier, JR | 1 |
| Nimkulrat, P | 1 |
| Leenutaphong, V | 1 |
| Sudtim, S | 1 |
| Rodríguez-Granados, MT | 1 |
| Carrascosa, JM | 1 |
| Gárate, T | 1 |
| Gómez-Díez, S | 1 |
| Guimaraens-Juantorena, D | 1 |
| Hara, T | 1 |
| Nishikawa, T | 1 |
| Sui, H | 1 |
| Kawakami, K | 1 |
| Matsumoto, H | 1 |
| Tanaka, N | 1 |
| Delrosso, G | 1 |
| Bornacina, C | 1 |
| Farinelli, P | 1 |
| Bellinzona, F | 1 |
| Leigheb, G | 1 |
| Colombo, E | 1 |
| Vohr, HW | 1 |
| Homey, B | 1 |
| Schuppe, HC | 1 |
| Kind, P | 1 |
| Antonello, C | 1 |
| Zagotto, G | 1 |
| Mobilio, S | 1 |
| Marzano, C | 1 |
| Gia, O | 1 |
| Uriarte, E | 1 |
| Yasui, Y | 1 |
| Hirone, T | 1 |
| Korffmacher, H | 1 |
| Hartwig, R | 1 |
| Matthes, U | 1 |
| Dirschka, T | 1 |
| Albassam, A | 1 |
| Weindorf, N | 1 |
| Altmeyer, P | 2 |
| Bech-Thomsen, N | 3 |
| Angelo, HR | 1 |
| Wulf, HC | 3 |
| Moysan, A | 1 |
| Morlière, P | 1 |
| Averbeck, D | 1 |
| Dubertret, L | 1 |
| Sakuntabhai, A | 1 |
| Matthews, JN | 1 |
| Farr, PM | 1 |
| Nilsson, R | 1 |
| Maurer, T | 1 |
| Redmond, N | 1 |
| Calzavara-Pinton, PG | 1 |
| Ortel, B | 1 |
| Carlino, AM | 1 |
| Honigsmann, H | 1 |
| De Panfilis, G | 1 |
| Knudsen, EA | 1 |
| Neumann, NJ | 2 |
| Ruzicka, T | 2 |
| Lehmann, P | 3 |
| Kerscher, M | 5 |
| Degitz, K | 1 |
| Plewig, G | 1 |
| Röcken, M | 1 |
| Morison, WL | 2 |
| Marwaha, S | 1 |
| Beck, L | 1 |
| Mäkinen, M | 1 |
| Forbes, PD | 1 |
| Stenbäck, F | 1 |
| Kumar, JR | 1 |
| Haberman, HF | 1 |
| Ranadive, NS | 1 |
| Conconi, MT | 1 |
| Montesi, F | 1 |
| Parnigotto, PP | 1 |
| Calzavara-Pinton, P | 1 |
| Clark, SM | 1 |
| Wilkinson, SM | 1 |
| Gruss, C | 2 |
| Behrens, S | 2 |
| Reuther, T | 1 |
| Husebo, L | 1 |
| Neumann, N | 1 |
| Grundmann-Kollmann, M | 2 |
| Leiter, U | 1 |
| Gottlöber, P | 1 |
| Mooser, G | 1 |
| Krähn, G | 1 |
| Schempp, CM | 1 |
| Schöpf, E | 1 |
| Simon, JC | 1 |
| Behrens-Williams, S | 1 |
| Peter, RU | 1 |
| Bernard, FX | 1 |
| Barrault, C | 1 |
| Deguercy, A | 1 |
| De Wever, B | 1 |
| Rosdy, M | 1 |
1 review available for methoxsalen and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
[Bullous phototoxic contact dermatitis caused by Ruta graveolens L. (garden rue), Rutaceae. Case report and review of literature].
Topics: 5-Methoxypsoralen; Alkaloids; Anti-Infective Agents, Local; Carcinogens; Cross-Linking Reagents; Der | 1999 |
6 trials available for methoxsalen and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Erythema action spectrum of topical 8-methoxypsoralen-sensitized skin re-evaluated: implications for routine clinical practice.
Topics: Action Spectrum; Adult; Aged; Analysis of Variance; Dermatitis, Phototoxic; Dose-Response Relationsh | 2016 |
Bath PUVA and psoriasis: is a milder treatment a worse treatment?
Topics: Adult; Baths; Clinical Protocols; Dermatitis, Phototoxic; Female; Humans; Male; Methoxsalen; Middle | 2008 |
Rapid decline in photosensitivity after 8-methoxypsoralen bathwater delivery.
Topics: Baths; Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitizing Agents; PUVA Therapy; Time Fact | 1996 |
Evaluation of PUVA bath phototoxicity.
Topics: Adult; Dermatitis, Phototoxic; Female; Humans; Male; Methoxsalen; Middle Aged; PUVA Therapy; Referen | 1997 |
Narrow band UVB (311 nm) phototherapy and PUVA photochemotherapy: a combination.
Topics: Administration, Cutaneous; Adult; Aged; Dermatitis, Phototoxic; Erythema; Humans; Male; Methoxsalen; | 1998 |
The time course of phototoxicity of topical PUVA: 8-methoxypsoralen cream-PUVA vs. 8-methoxypsoralen gel-PUVA.
Topics: Dermatitis, Phototoxic; Female; Gels; Humans; Male; Methoxsalen; Ointments; PUVA Therapy; Skin Tests | 1999 |
45 other studies available for methoxsalen and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Phototoxic Contact Dermatitis From Over-the-counter 8-Methoxypsoralen.
Topics: Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitizing Agents; Ultraviolet Rays | 2022 |
Absence of phototoxicity/photoirritation potential of bergamottin determined In Vitro using OECD TG 432.
Topics: Dermatitis, Phototoxic; Furocoumarins; Humans; Methoxsalen; Neutral Red; Organisation for Economic C | 2022 |
Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats.
Topics: Acridines; Administration, Cutaneous; Administration, Oral; Animals; Dermatitis, Phototoxic; Fluoroq | 2017 |
The abdominal skin of female Sprague-Dawley rats is more sensitive than the back skin to drug-induced phototoxicity.
Topics: Abdomen; Administration, Oral; Animals; Back; Dermatitis, Phototoxic; Disease Models, Animal; Doxycy | 2017 |
Assessment of phototoxicity in pigmented Long-Evans rat: sparfloxacin and 8-methoxypsoralen.
Topics: Animals; Cell Proliferation; Dermatitis, Phototoxic; Eye; Female; Fluoroquinolones; Lymph Nodes; Met | 2018 |
Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk.
Topics: Administration, Oral; Animals; Dermatitis, Phototoxic; Feasibility Studies; Male; Methoxsalen; Pyrid | 2019 |
Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anthracenes; Dermatitis, Phototoxic; Femal | 2015 |
Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity.
Topics: Bithionol; Cell Survival; Cells, Cultured; Coumarins; Dermatitis, Phototoxic; DNA Breaks, Double-Str | 2011 |
Photosensitization by 8-methoxypsoralen.
Topics: Dermatitis, Phototoxic; Methoxsalen; Photosensitivity Disorders | 1961 |
Erythema and tumor formation in methoxsalen-treated mice exposed to flourescent light.
Topics: Animals; Dermatitis, Phototoxic; Erythema; Humans; Light; Methoxsalen; Mice; Neoplasms; Photosensiti | 1960 |
The in vivo destruction of succinic dehydrogenase activity of guinea-pig skin by photosensitization with psoralen or methoxsalen.
Topics: Dermatitis, Phototoxic; Ficusin; Methoxsalen; Oxidation-Reduction; Photosensitivity Disorders; Skin; | 1961 |
Altered reactivity of tissues with photo-sensitivity.
Topics: Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitivity Disorders | 1962 |
Photosensitization of the eye with methoxsalen.
Topics: Dermatitis, Phototoxic; Eye; Humans; Methoxsalen; Photosensitivity Disorders | 1963 |
[EXPERIMENTAL STUDIES ON THE EFFECT OF PHOTODYNAMIC REACTIONS ON THE PATHOGENESIS OF LIGHT CARCINOMA].
Topics: Dermatitis, Phototoxic; Khellin; Light; Methoxsalen; Neoplasms, Experimental; Photosensitivity Disor | 1963 |
THE EFFECT OF METHOXYPSORALEN-INDUCED PHOTOSENSITIZATION UPON EPIDERMAL AND SERUM SULFHYDRYL.
Topics: Blood Chemical Analysis; Dermatitis, Phototoxic; Epidermis; Metabolism; Methoxsalen; Photosensitivit | 1964 |
EFFECT OF HUMIDITY ON THE PHOTOSENSITIVE RESPONSE TO 8-METHOXYPSORALEN.
Topics: Animals; Dermatitis, Phototoxic; Guinea Pigs; Humidity; Methoxsalen; Pharmacology; Photosensitivity | 1965 |
A SIMPLE MICROBIOLOGICAL METHOD FOR DEMONSTRATING PHOTOTOXIC COMPOUNDS.
Topics: Biological Assay; Candida; Chlordiazepoxide; Coal Tar; Coumarins; Dermatitis, Phototoxic; Fluorescen | 1965 |
Controlled trial of methoxsalen in solar dermatitis of Chippewa Indians.
Topics: Dermatitis; Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitivity Disorders; Sunburn | 1960 |
Mechanism of psoralen photosensitization and in vivo biological action spectrum of 8-methoxypsoralen.
Topics: Coumarins; Dermatitis, Phototoxic; Ficusin; Humans; Methoxsalen; Photosensitivity Disorders | 1961 |
[Study on using in vitro 3T3 neutral red uptake to test phototoxicity].
Topics: Animals; BALB 3T3 Cells; Cosmetics; Dermatitis, Phototoxic; Indicators and Reagents; Methoxsalen; Mi | 2005 |
Use of the yeast Saccharomyces cerevisiae as a pre-screening approach for assessment of chemical-induced phototoxicity.
Topics: 5-Methoxypsoralen; Dermatitis, Phototoxic; Drug Evaluation, Preclinical; Methoxsalen; Saccharomyces | 2006 |
Phototoxicity of new psoralen-containing gels and creams versus bath PUVA.
Topics: 5-Methoxypsoralen; Administration, Topical; Adolescent; Adult; Aged; Baths; Dermatitis, Phototoxic; | 2005 |
[Consensus document on bath-PUVA therapy. The Spanish Photobiology Group of the Spanish Academy of Dermatology and Venereology].
Topics: Administration, Cutaneous; Baths; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Dose-Res | 2007 |
In vivo photochemical skin micronucleus test using a sunlight simulator: detection of 8-methoxypsoralen and benzo[a]pyrene in hairless mice.
Topics: Animals; Benzo(a)pyrene; Dermatitis, Phototoxic; Humans; Male; Methoxsalen; Mice; Mice, Hairless; Mi | 2007 |
Detection of photoreactivity demonstrated in a modified local lymph node assay in mice.
Topics: Allergens; Animals; Chlorpromazine; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dinitrofluoro | 1994 |
Synthesis and characterization of new methylpsoralens as potential photochemotherapeutic agents.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cross-Linking Reagents; Dermatitis, Phototoxic; DN | 1994 |
Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting.
Topics: 5-Methoxypsoralen; Animals; Cell Count; Dermatitis, Phototoxic; Dose-Response Relationship, Radiatio | 1994 |
Contact allergy to 8-methoxypsoralen.
Topics: Adult; Dermatitis, Allergic Contact; Dermatitis, Phototoxic; Drug Eruptions; Eczema, Dyshidrotic; Fe | 1994 |
Skin pigmentation as a predictor of minimal phototoxic dose after oral methoxsalen.
Topics: Administration, Oral; Adult; Aged; Dermatitis, Phototoxic; Humans; Methoxsalen; Middle Aged; PUVA Th | 1994 |
Evaluation of phototoxic and photogenotoxic risk associated with the use of photosensitizers in suntan preparations: application to tanning preparations containing bergamot oil.
Topics: 5-Methoxypsoralen; Blister; Dermatitis, Phototoxic; Gas Chromatography-Mass Spectrometry; Humans; Me | 1993 |
Improved prediction of the minimal phototoxic dose in PUVA therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dermatitis, Phototoxic; Drug Administration Schedule; Ey | 1994 |
A polychromatic action spectrum for photosensitivity to orally administered 8-methoxypsoralen in humans.
Topics: Administration, Oral; Adult; Dermatitis, Phototoxic; Dose-Response Relationship, Radiation; Erythema | 1994 |
A standard protocol for phototoxicity testing. Results from an interlaboratory study.
Topics: Acridines; Administration, Cutaneous; Animals; Clinical Protocols; Dermatitis, Phototoxic; Guinea Pi | 1993 |
Phototesting and phototoxic side effects in bath PUVA.
Topics: Administration, Cutaneous; Baths; Dermatitis, Phototoxic; Humans; Methoxsalen; Psoriasis; PUVA Thera | 1993 |
Ultraviolet A-induced photodegradation of 5-methoxypsoralen, 8-methoxypsoralen and psoralen reduces the biological effectiveness of the furocoumarins in vivo.
Topics: 5-Methoxypsoralen; Dermatitis, Phototoxic; Dose-Response Relationship, Radiation; Ficusin; Humans; M | 1995 |
Rapid decrease of phototoxicity after PUVA bath therapy with 8-methoxypsoralen.
Topics: Dermatitis, Phototoxic; Humans; Methoxsalen; Photosensitizing Agents; PUVA Therapy; Time Factors | 1996 |
PUVA-induced phototoxicity: incidence and causes.
Topics: Clinical Protocols; Dermatitis, Phototoxic; Doxycycline; Drug Interactions; Female; Herpes Zoster; H | 1997 |
Quinolone antibacterials: a new class of photochemical carcinogens.
Topics: Animals; Anti-Infective Agents; Carcinoma, Squamous Cell; Ciprofloxacin; Dermatitis, Phototoxic; Fle | 1997 |
Comparative studies on the tolerance to photoinduced cutaneous inflammatory reactions by psoralen and rose bengal.
Topics: Animals; Capillary Permeability; Dermatitis, Phototoxic; Desensitization, Immunologic; Erythema; Fic | 1997 |
Psoralen UVA therapy for linear and generalized morphea.
Topics: Adolescent; Adult; Dermatitis, Phototoxic; Female; Follow-Up Studies; Humans; Male; Methoxsalen; Mid | 1997 |
Antiproliferative activity and phototoxicity of some methyl derivatives of 5-methoxypsoralen and 5-methoxyangelicin.
Topics: 5-Methoxypsoralen; Animals; Antineoplastic Agents; Cell Division; Dermatitis, Phototoxic; Dose-Respo | 1998 |
Phototoxic contact dermatitis from 5-methoxypsoralen in aromatherapy oil.
Topics: 5-Methoxypsoralen; Aromatherapy; Baths; Child; Dermatitis, Phototoxic; Female; Humans; Methoxsalen | 1998 |
Kinetics of photosensitivity in bath-PUVA photochemotherapy.
Topics: Adult; Baths; Dermatitis, Phototoxic; Female; Humans; Male; Methoxsalen; Photosensitizing Agents; PU | 1998 |
Assessment of minimal phototoxic dose following 8-methoxypsoralen bath: maximal reaction on average after 5 days.
Topics: Adult; Dermatitis, Phototoxic; Female; Humans; Male; Methoxsalen; PUVA Therapy; Time Factors | 2000 |
Development of a highly sensitive in vitro phototoxicity assay using the SkinEthic reconstructed human epidermis.
Topics: 4-Aminobenzoic Acid; 5-Methoxypsoralen; Adult; Antipruritics; Benzophenones; Chlorpromazine; Colorin | 2000 |