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methoxsalen and Cutaneous T-Cell Lymphoma

methoxsalen has been researched along with Cutaneous T-Cell Lymphoma in 32 studies

Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Research Excerpts

ExcerptRelevanceReference
" Fourteen patients (all male) aged 38 to 72 years with CTCL of the mycosis fungoides type, stage IIa/IIb, and a 72-year-old male patient with a Ki-1 lymphoma were treated twice a month for 6 months with extracorporeal photochemotherapy using oral 8-methoxypsoralen as photosensitizer in combination with interferon alfa-2a subcutaneously 3 times a week in the maximal tolerable dosage (ie, up to 18 x 10(6) U)."2.70Treatment of stage II cutaneous T-cell lymphoma with interferon alfa-2a and extracorporeal photochemotherapy: a prospective controlled trial. ( Hipler, UC; Knopf, B; Koch, HJ; Liebold, K; Looks, A; Meyer, J; Wollina, U, 2001)
" Safety was assessed using reports of adverse device effects (ADEs) and unanticipated ADEs (UADEs), device malfunctions and defects, vital signs, laboratory parameters and physical examinations."1.35Safety of a new, single, integrated, closed photopheresis system in patients with cutaneous T-cell lymphoma. ( Bisaccia, E; Geskin, L; Vonderheid, EC, 2009)
"Hypericin is a photodynamic compound activated by either visible (400-700 nm) or UVA (320-400 nm) light, and has been shown to inhibit the growth of a variety of neoplastic cell types."1.30Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders. ( Fox, FE; Niu, Z; Rook, AH; Tobia, A, 1998)
" In serum, peak 8-MOP concentrations were reached < or =40 min following ingestion; the half-life of 8-MOP in the serum was 50+/-14 min (n=7)."1.30Pharmacokinetics of 8-methoxypsoralen during extracorporeal photopheresis. ( Nestle, FO; Panizzon, R; Shephard, SE, 1999)
"The number of chromosomal aberrations and SCE were increased upon treatment, but only transiently, returning to basal levels between consecutive treatments."1.28Cytogenetic effects during extracorporeal photopheresis treatment of two patients with cutaneous T-cell lymphoma. ( Gebauer, HJ; Küster, W; Meschig, R; Peterseim, UM; Plewig, G, 1991)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's19 (59.38)18.2507
2000's5 (15.63)29.6817
2010's7 (21.88)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Nakahashi, K1
Nihira, K1
Suzuki, M1
Ishii, T1
Masuda, K1
Mori, K1
Szczepiorkowski, ZM1
Burnett, CA1
Dumont, LJ1
Abhyankar, SH1
Holien, T1
Gederaas, OA1
Darvekar, SR1
Christensen, E1
Peng, Q1
Trautinger, F2
Tatsuno, K1
Yamazaki, T1
Hanlon, D1
Han, P1
Robinson, E1
Sobolev, O1
Yurter, A1
Rivera-Molina, F1
Arshad, N1
Edelson, RL3
Galluzzi, L1
Taverna, F1
Coluccia, P1
Arienti, F1
Birolini, A1
Terranova, L1
Mazzocchi, A1
Rini, F1
Mariani, L1
Melani, C1
Ravagnani, F1
Bisaccia, E2
Vonderheid, EC1
Geskin, L1
Kofoed, K1
Schiødt, I1
Gniadecki, R1
Just, U1
Knobler, R2
Crovetti, G1
Carabelli, A1
Berti, E1
Guizzardi, M1
Fossati, S1
De Filippo, C1
Bertani, E1
Umeh, OC1
Kubak, BM1
Pegues, DA1
Leibowitz, MR1
Froch, L1
Schreiner, T1
Gaczkowski, A1
Scharffetter-Kochanek, K1
Borberg, H1
Bunn, PA1
Lim, HW1
Wolf, P1
Müllegger, R1
Cerroni, L1
Aigner, R1
Fueger, G1
Höfler, G1
Derbaschnig, J1
Kerl, H1
Duvic, M1
Hester, JP1
Lemak, NA1
Gasparro, FP3
Felli, A1
Schmitt, IM1
Zic, JA2
Stricklin, GP3
Greer, JP1
Kinney, MC1
Shyr, Y1
Wilson, DC1
King, LE3
Fox, FE1
Niu, Z1
Tobia, A1
Rook, AH1
Miller, JL1
Shephard, SE2
Nestle, FO1
Panizzon, R1
Panizzon, RG1
Wollina, U1
Looks, A1
Meyer, J1
Knopf, B1
Koch, HJ1
Liebold, K1
Hipler, UC1
Heald, P1
Rook, A1
Perez, M1
Wintroub, B1
Jegasothy, B1
Gasparro, F1
Berger, C2
Edelson, R1
Zic, J1
Arzubiaga, C1
Salhany, KE1
Parker, RA1
Wilson, D1
Greer, J1
Strauss, RG1
Malane, MS1
Peterseim, UM1
Küster, W1
Gebauer, HJ1
Meschig, R1
Plewig, G1
Marks, DI1
Rockman, SP1
Oziemski, MA1
Fox, RM1
Armus, S1
Keyes, B1
Cahill, C1
Crater, D1
Scarborough, D1
Klainer, A1
Heald, PW1
Perez, MI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Extracorporeal Photopheresis as Immunomodulatory Therapy of Subclinical Antibody-mediated Rejection After Lung Transplantation: a Prospective RCT[NCT06112951]80 participants (Anticipated)Interventional2023-11-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for methoxsalen and Cutaneous T-Cell Lymphoma

ArticleYear
Phototherapy of cutaneous T-cell lymphomas.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2018, Dec-05, Volume: 17, Issue:12

    Topics: Humans; Lymphoma, T-Cell, Cutaneous; Lymphomatoid Papulosis; Methoxsalen; Mycosis Fungoides; Photose

2018
[Documented effect of extra corporeal photopheresis on T-cell mediated diseases].
    Ugeskrift for laeger, 2011, Jun-27, Volume: 173, Issue:26

    Topics: Evidence-Based Medicine; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Ph

2011
Photopheresis (extracorporeal photochemotherapy).
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:1

    Topics: Graft Rejection; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photophere

2013
Photopheresis for the treatment of cutaneous T-cell lymphoma.
    Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:5

    Topics: Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photopheresis; Skin Neoplasms

1995
Psoralen photobiology: the relationship between DNA damage, chromatin structure, transcription, and immunogenic effects.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1997, Volume: 143

    Topics: Animals; Base Composition; Base Sequence; Chromatin; DNA; DNA Damage; Furocoumarins; Humans; Lymphom

1997
The North American experience with photopheresis.
    Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, 1999, Volume: 3, Issue:1

    Topics: Arthritis, Rheumatoid; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Nort

1999
Current status of hemapheresis in the United States.
    Journal of clinical apheresis, 1991, Volume: 6, Issue:2

    Topics: Blood Banks; Blood Component Removal; Blood Transfusion, Autologous; Data Collection; Hematopoietic

1991
T cell molecular targets for psoralens.
    Annals of the New York Academy of Sciences, 1991, Dec-30, Volume: 636

    Topics: Animals; DNA; Humans; Lipid Metabolism; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Proteins; PUVA The

1991
Photopheresis: present and future aspects.
    Journal of photochemistry and photobiology. B, Biology, 1991, Volume: 10, Issue:1-2

    Topics: Animals; Humans; Immune System Diseases; Immunotherapy; Lymphocyte Depletion; Lymphoma, T-Cell, Cuta

1991

Trials

2 trials available for methoxsalen and Cutaneous T-Cell Lymphoma

ArticleYear
Apheresis buffy coat collection without photoactivation has no effect on apoptosis, cell proliferation, and total viability of mononuclear cells collected using photopheresis systems.
    Transfusion, 2018, Volume: 58, Issue:4

    Topics: Adult; Annexin A5; Apoptosis; Blood Buffy Coat; Blood Component Removal; Cell Proliferation; Cells,

2018
Treatment of stage II cutaneous T-cell lymphoma with interferon alfa-2a and extracorporeal photochemotherapy: a prospective controlled trial.
    Journal of the American Academy of Dermatology, 2001, Volume: 44, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Humans; Injections, Subcutaneous; Interfer

2001

Other Studies

21 other studies available for methoxsalen and Cutaneous T-Cell Lymphoma

ArticleYear
A novel mouse model of cutaneous T-cell lymphoma revealed the combined effect of mogamulizumab with psoralen and ultraviolet a therapy.
    Experimental dermatology, 2022, Volume: 31, Issue:11

    Topics: Animals; Ficusin; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Mice; Mycosis Fungoides; PUVA Therapy; S

2022
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
    Lasers in surgery and medicine, 2018, Volume: 50, Issue:5

    Topics: Aminolevulinic Acid; Cell Culture Techniques; Graft vs Host Disease; Humans; Lymphoma, T-Cell, Cutan

2018
Extracorporeal photochemotherapy induces bona fide immunogenic cell death.
    Cell death & disease, 2019, 08-02, Volume: 10, Issue:8

    Topics: Adenosine Triphosphate; Animals; Antigens, Neoplasm; Apoptosis; CD8-Positive T-Lymphocytes; Cell Dif

2019
Biological quality control for extracorporeal photochemotherapy: Assessing mononuclear cell apoptosis levels in ECP bags of chronic GvHD patients.
    Journal of clinical apheresis, 2015, Volume: 30, Issue:3

    Topics: Adult; Aged; Apoptosis; Blood Component Removal; Cell Proliferation; Cell Separation; Female; Flow C

2015
Safety of a new, single, integrated, closed photopheresis system in patients with cutaneous T-cell lymphoma.
    The British journal of dermatology, 2009, Volume: 161, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Equ

2009
Photopheresis in cutaneous T-cell lymphoma: five-year experience.
    The International journal of artificial organs, 2000, Volume: 23, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Female; Humans; Interferon-alpha; Lymphoma, T-Cell, Cutaneous; M

2000
Corynebacterium jeikeium sepsis after 8-methoxypsolaren photopheresis for cutaneous T-cell lymphoma.
    Diagnostic microbiology and infectious disease, 2004, Volume: 50, Issue:1

    Topics: Aged; Bacteremia; Corynebacterium; Corynebacterium Infections; Follow-Up Studies; Humans; Immunocomp

2004
Small-scale extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma: a report of 3 cases.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2005, Volume: 32, Issue:2

    Topics: Aged; Aged, 80 and over; Female; Humans; Lymphoma, T-Cell, Cutaneous; Male; Methoxsalen; Middle Aged

2005
Cutaneous T cell lymphomas.
    BMJ (Clinical research ed.), 1994, Feb-26, Volume: 308, Issue:6928

    Topics: Administration, Topical; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Methoxsalen; Randomiz

1994
Photoaccentuated erythroderma associated with CD4+ T lymphocytopenia: successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:2 Pt 2

    Topics: 5-Methoxypsoralen; Dermatitis, Exfoliative; HIV Seronegativity; Humans; Interferon alpha-2; Interfer

1996
Photopheresis therapy for cutaneous T-cell lymphoma.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Dermatitis, Exfoliative; Female; Follow-Up Studies; Forecasting; Hum

1996
Long-term follow-up of patients with cutaneous T-cell lymphoma treated with extracorporeal photochemotherapy.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Lymphoma, T-Cell, Cutaneous; Male

1996
Photoactivated hypericin is an anti-proliferative agent that induces a high rate of apoptotic death of normal, transformed, and malignant T lymphocytes: implications for the treatment of cutaneous lymphoproliferative and inflammatory disorders.
    The Journal of investigative dermatology, 1998, Volume: 111, Issue:2

    Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cells, Cultured; Humans; Keratitis; Lymphocyte Activa

1998
Pharmacokinetics of 8-methoxypsoralen during extracorporeal photopheresis.
    Photodermatology, photoimmunology & photomedicine, 1999, Volume: 15, Issue:2

    Topics: Adult; Aged; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationsh

1999
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
    Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:2

    Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans

1999
Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy.
    Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:3

    Topics: CD4-CD8 Ratio; Dermatitis, Exfoliative; Follow-Up Studies; Humans; Lymphoma, T-Cell, Cutaneous; Meth

1992
Extracorporeal photopheresis for the treatment of cutaneous T-cell lymphoma.
    Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:5 Pt 1

    Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Extracorporeal Circulation; Female; Human

1992
Cytogenetic effects during extracorporeal photopheresis treatment of two patients with cutaneous T-cell lymphoma.
    Archives of dermatological research, 1991, Volume: 283, Issue:2

    Topics: Administration, Oral; Aged; Chromosome Aberrations; Female; Humans; Lymphocytes; Lymphoma, T-Cell, C

1991
Mechanisms of lymphocytotoxicity induced by extracorporeal photochemotherapy for cutaneous T cell lymphoma.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:6

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Deoxyadenosines; DNA; DNA Damage; Humans; In Vitro Tech

1990
Photopheresis for the treatment of cutaneous T cell lymphoma.
    Journal of the American Academy of Dermatology, 1990, Volume: 23, Issue:5 Pt 1

    Topics: Adult; Aged; Aged, 80 and over; Dermatitis, Exfoliative; Female; Humans; Leukapheresis; Lymphoma, T-

1990
Dosage guidelines: extracorporeal photochemotherapy (photopheresis)
    Archives of dermatology, 1990, Volume: 126, Issue:10

    Topics: Humans; Lymphoma, T-Cell, Cutaneous; Methoxsalen; Photochemotherapy; Skin Neoplasms

1990