methoxsalen has been researched along with Chemical and Drug Induced Liver Injury in 13 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-eight patients with plaque-type psoriasis were enrolled in a double-blind psoralen plus ultraviolet A (PUVA) treatment study comparing the efficacy and side effects of 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP)." | 9.07 | Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. ( Berg, M; Ros, AM, 1994) |
| "Thirty-eight patients with plaque-type psoriasis were enrolled in a double-blind psoralen plus ultraviolet A (PUVA) treatment study comparing the efficacy and side effects of 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP)." | 5.07 | Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. ( Berg, M; Ros, AM, 1994) |
| "A 55-year-old woman with psoriasis vulgaris was treated with oral 5-methoxypsoralen and UVA photochemotherapy." | 3.70 | Hepatitis from 5-methoxypsoralen occurring in a patient with previous flucloxacillin hepatitis. ( Cooper, A; Stephens, RB, 1999) |
| "A 59-year-old white woman with long-standing psoriasis, who had a damaged liver from methotrexate, developed a toxic hepatitis while on oral methoxsalen photochemotherapy (PUVA)." | 3.66 | Toxic hepatitis from oral methoxsalen photochemotherapy (PUVA). ( Pariser, DM; Wyles, RJ, 1980) |
| " However, psoralens safety for long-term use is a concern." | 1.46 | 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. ( Jiang, Z; Li, Z; Wang, T; Xu, D; Yin, M; Yuan, Z; Zhang, L; Zhao, G; Zhou, W; Zhou, Z, 2017) |
| "Post-treatment with methoxsalen must be given early and is only partially effective in mice." | 1.27 | The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice. ( Amouyal, G; Carrion-Pavlov, Y; Degott, C; Descatoire, V; Geneve, J; Labbe, G; Larrey, D; Letteron, P; Pessayre, D; Tinel, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Liu, S | 1 |
| Cheng, R | 1 |
| He, H | 1 |
| Ding, K | 1 |
| Zhang, R | 1 |
| Chai, Y | 1 |
| Yu, Q | 1 |
| Huang, X | 1 |
| Zhang, L | 3 |
| Jiang, Z | 3 |
| Zhao, G | 2 |
| Xu, D | 2 |
| Yuan, Z | 2 |
| Zhou, W | 2 |
| Li, Z | 2 |
| Yin, M | 1 |
| Zhou, Z | 1 |
| Wang, T | 2 |
| Elhafiz, M | 1 |
| Jiang, J | 1 |
| Das, D | 1 |
| Fan, S | 1 |
| Wang, C | 1 |
| Liu, WX | 1 |
| Jia, FL | 1 |
| He, YY | 1 |
| Zhang, BX | 1 |
| Pariser, DM | 1 |
| Wyles, RJ | 1 |
| Berg, M | 1 |
| Ros, AM | 1 |
| Stephens, RB | 1 |
| Cooper, A | 1 |
| Bjellerup, M | 1 |
| Bruze, M | 1 |
| Hansson, A | 1 |
| Krook, G | 1 |
| Ljunggren, B | 1 |
| Labbe, G | 1 |
| Descatoire, V | 1 |
| Letteron, P | 1 |
| Degott, C | 1 |
| Tinel, M | 1 |
| Larrey, D | 1 |
| Carrion-Pavlov, Y | 1 |
| Geneve, J | 1 |
| Amouyal, G | 1 |
| Pessayre, D | 1 |
| Ortel, B | 1 |
| Tanew, A | 1 |
| Hönigsmann, H | 1 |
1 review available for methoxsalen and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
1 trial available for methoxsalen and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen.
Topics: 5-Methoxypsoralen; Absorption; Adult; Aged; Chemical and Drug Induced Liver Injury; Double-Blind Met | 1994 |
11 other studies available for methoxsalen and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Liver; Meth | 2023 |
8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Bile Acids and Salts; Cell Line; Chemical an | 2017 |
Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Female; Homeostasis; Humans; Liver; Meth | 2019 |
Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice.
Topics: 5-Methoxypsoralen; Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Antioxidants; | 2012 |
Toxic hepatitis from oral methoxsalen photochemotherapy (PUVA).
Topics: Administration, Oral; Chemical and Drug Induced Liver Injury; Female; Humans; Methoxsalen; Middle Ag | 1980 |
Hepatitis from 5-methoxypsoralen occurring in a patient with previous flucloxacillin hepatitis.
Topics: 5-Methoxypsoralen; Chemical and Drug Induced Liver Injury; Female; Floxacillin; Humans; Methoxsalen; | 1999 |
Liver injury following administration of 8-methoxypsoralen during PUVA therapy.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; H | 1979 |
The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochr | 1987 |
Vitiligo treatment.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA; Huma | 1986 |