methoxsalen has been researched along with Cell Transformation, Neoplastic in 8 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response data for both survival and transformation were obtained as a function of 8-methoxypsoralen (8-MOP) concentration and UVA dose." | 1.27 | Neoplastic transformation of C3H mouse embryo 10T1/2 cells by 8-methoxypsoralen plus UVA radiation. ( Ananthaswamy, HN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moore, SP | 1 |
| Blount, H | 1 |
| Coohill, TP | 1 |
| Uwaifo, AO | 1 |
| Billings, PC | 1 |
| Heidelberger, C | 1 |
| Levy, E | 1 |
| Baroche, C | 1 |
| Barret, JM | 1 |
| Alapetite, C | 1 |
| Salles, B | 1 |
| Averbeck, D | 1 |
| Moustacchi, E | 1 |
| Burger, PM | 1 |
| Simons, JW | 1 |
| Evans, DL | 1 |
| Morrow, KJ | 1 |
| Dean, SW | 1 |
| Ananthaswamy, HN | 1 |
| Musajo, L | 1 |
| Rodighiero, G | 1 |
1 review available for methoxsalen and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Mode of photosensitizing action of furocoumarins.
Topics: Animals; Bacteria; Cell Transformation, Neoplastic; Cells; Coumarins; Dermatitis, Contact; DNA; Fura | 1972 |
7 other studies available for methoxsalen and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
SV40 induction from a mammalian cell line by ultraviolet radiation and the photosensitizers 8-methoxypsoralen and angelicin.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Furocoumarins; Intercalating Agents | 1983 |
Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Survival; Cell Transformation, Neoplastic; Coumarins; Cricet | 1983 |
Activated ras oncogene and specifically acquired resistance to cisplatin in human mammary epithelial cells: induction of DNA cross-links and their repair.
Topics: Breast; Cell Division; Cell Line; Cell Line, Transformed; Cell Survival; Cell Transformation, Neopla | 1994 |
Mutagenicity and carcinogenicity of 8-MOP/UVA in cell cultures.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Humans; In Vitro Techniques; | 1978 |
8-methoxypsoralen induced alterations of mammalian cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Cricetinae; Cultu | 1979 |
Repair of 8-methoxypsoralen + UVA-induced damage in specific sequences in chromosomal and episomal DNA in human cells.
Topics: Cell Line; Cell Transformation, Neoplastic; DNA; DNA Damage; DNA Repair; Fanconi Anemia; Genes; Huma | 1989 |
Neoplastic transformation of C3H mouse embryo 10T1/2 cells by 8-methoxypsoralen plus UVA radiation.
Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug | 1985 |