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methoxsalen and Cell Transformation, Neoplastic

methoxsalen has been researched along with Cell Transformation, Neoplastic in 8 studies

Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
" Dose-response data for both survival and transformation were obtained as a function of 8-methoxypsoralen (8-MOP) concentration and UVA dose."1.27Neoplastic transformation of C3H mouse embryo 10T1/2 cells by 8-methoxypsoralen plus UVA radiation. ( Ananthaswamy, HN, 1985)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19907 (87.50)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moore, SP1
Blount, H1
Coohill, TP1
Uwaifo, AO1
Billings, PC1
Heidelberger, C1
Levy, E1
Baroche, C1
Barret, JM1
Alapetite, C1
Salles, B1
Averbeck, D1
Moustacchi, E1
Burger, PM1
Simons, JW1
Evans, DL1
Morrow, KJ1
Dean, SW1
Ananthaswamy, HN1
Musajo, L1
Rodighiero, G1

Reviews

1 review available for methoxsalen and Cell Transformation, Neoplastic

ArticleYear
Mode of photosensitizing action of furocoumarins.
    Photophysiology, 1972, Issue:7

    Topics: Animals; Bacteria; Cell Transformation, Neoplastic; Cells; Coumarins; Dermatitis, Contact; DNA; Fura

1972

Other Studies

7 other studies available for methoxsalen and Cell Transformation, Neoplastic

ArticleYear
SV40 induction from a mammalian cell line by ultraviolet radiation and the photosensitizers 8-methoxypsoralen and angelicin.
    Photochemistry and photobiology, 1983, Volume: 37, Issue:6

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Furocoumarins; Intercalating Agents

1983
Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Aflatoxin B1; Aflatoxins; Animals; Cell Survival; Cell Transformation, Neoplastic; Coumarins; Cricet

1983
Activated ras oncogene and specifically acquired resistance to cisplatin in human mammary epithelial cells: induction of DNA cross-links and their repair.
    Carcinogenesis, 1994, Volume: 15, Issue:5

    Topics: Breast; Cell Division; Cell Line; Cell Line, Transformed; Cell Survival; Cell Transformation, Neopla

1994
Mutagenicity and carcinogenicity of 8-MOP/UVA in cell cultures.
    Bulletin du cancer, 1978, Volume: 65, Issue:3

    Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Humans; In Vitro Techniques;

1978
8-methoxypsoralen induced alterations of mammalian cells.
    The Journal of investigative dermatology, 1979, Volume: 72, Issue:1

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Cricetinae; Cultu

1979
Repair of 8-methoxypsoralen + UVA-induced damage in specific sequences in chromosomal and episomal DNA in human cells.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Cell Line; Cell Transformation, Neoplastic; DNA; DNA Damage; DNA Repair; Fanconi Anemia; Genes; Huma

1989
Neoplastic transformation of C3H mouse embryo 10T1/2 cells by 8-methoxypsoralen plus UVA radiation.
    The Journal of investigative dermatology, 1985, Volume: 85, Issue:2

    Topics: Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug

1985