methoxsalen has been researched along with Body Weight in 10 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methoxsalen (MTS) is a natural bioactive compound found in a variety of plants that has many known biofunctions; however, its effects on osteoporosis and related mechanisms are not clear." | 3.85 | Methoxsalen supplementation attenuates bone loss and inflammatory response in ovariectomized mice. ( Choi, RY; Ham, JR; Hwang, YH; Kim, MJ; Lee, MK; Yee, ST, 2017) |
| " The two different methods of dosing were used on consecutive treatment days and the plasma 8-MOP concentration was measured on each occasion 2 h after ingestion of the crystalline form of 8-MOP, given to the nearest 10 mg." | 2.68 | Calculation of 8-methoxypsoralen dose according to body surface area in PUVA treatment. ( Diffey, BL; Farr, PM; Sakuntabhai, A, 1995) |
| " However, these finding as well as some hematological and serum electrolyte changes lacked a dose-response relationship." | 1.28 | Toxicity of 8-methoxypsoralen in cynomolgous monkeys (Macaca fascicularis). ( Brickl, R; Leuschner, F; Rozman, K; Rozman, T, 1989) |
| " In this study, 8-MOP was administered to male and female Fischer 344 rats without subsequent UVA exposure for the determination of toxic effects of the psoralen alone." | 1.27 | Subchronic toxicity in rats administered oral 8-methoxypsoralen. ( Davis, WE; Dunnick, JK; Jorgenson, TA; McConnell, EE; Rosen, VJ, 1984) |
| " These studies show that the psoralens with two potential DNA-binding sites (8-MOP and 5-MOP) were more toxic than psoralens with only one photoreactive site (5-MIP and 3-CEP)." | 1.27 | Toxicity of 8-methoxypsoralen, 5-methoxypsoralen, 3-carbethoxypsoralen, or 5-methylisopsoralen with ultraviolet radiation in the hairless (HRA/Skh) mouse. ( Davies, RE; Dunnick, JK; Forbes, PD; Iverson, WO, 1987) |
| "The acute oral and intraperitoneal LD50 values of micronized 8-Methoxypsoralen were determined in rats and mice." | 1.26 | Acute toxicity of micronized 8-methoxypsoralen in rodents. ( Apostolou, A; Comereski, CR; Williams, RE, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ham, JR | 1 |
| Choi, RY | 1 |
| Yee, ST | 1 |
| Hwang, YH | 1 |
| Kim, MJ | 1 |
| Lee, MK | 1 |
| Dunnick, JK | 2 |
| Davis, WE | 1 |
| Jorgenson, TA | 1 |
| Rosen, VJ | 1 |
| McConnell, EE | 1 |
| Sakuntabhai, A | 1 |
| Diffey, BL | 1 |
| Farr, PM | 1 |
| Wolff, K | 1 |
| Gschnait, F | 1 |
| Hönigsmann, H | 1 |
| Konrad, K | 1 |
| Parrish, JA | 1 |
| Fitzpatrick, TB | 1 |
| Apostolou, A | 1 |
| Williams, RE | 1 |
| Comereski, CR | 1 |
| Walther, T | 1 |
| Quednow, B | 1 |
| Haustein, UF | 1 |
| Meyer, FP | 1 |
| el Naser, H | 1 |
| Abdel Ghaffar, E | 1 |
| Mahmoud, SS | 1 |
| Rozman, T | 1 |
| Leuschner, F | 1 |
| Brickl, R | 1 |
| Rozman, K | 1 |
| Forbes, PD | 1 |
| Davies, RE | 1 |
| Iverson, WO | 1 |
| Kooyers, WM | 1 |
2 trials available for methoxsalen and Body Weight
| Article | Year |
|---|---|
Calculation of 8-methoxypsoralen dose according to body surface area in PUVA treatment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Body Height; Body Surface Area; Body Weight; Drug Admini | 1995 |
Phototesting and dosimetry for photochemotherapy.
Topics: Body Weight; Clinical Trials as Topic; Erythema; Humans; Methoxsalen; Psoriasis; Skin Pigmentation; | 1977 |
8 other studies available for methoxsalen and Body Weight
| Article | Year |
|---|---|
Methoxsalen supplementation attenuates bone loss and inflammatory response in ovariectomized mice.
Topics: Animals; Biomarkers; Body Weight; Bone and Bones; Bone Density; Core Binding Factor Alpha 1 Subunit; | 2017 |
Subchronic toxicity in rats administered oral 8-methoxypsoralen.
Topics: Administration, Oral; Adrenal Cortex; Animals; Body Weight; Female; Liver; Male; Methoxsalen; Rats; | 1984 |
Acute toxicity of micronized 8-methoxypsoralen in rodents.
Topics: Administration, Oral; Animals; Body Weight; Injections, Intraperitoneal; Lethal Dose 50; Methoxsalen | 1979 |
Variability of serum levels for three oral 8-methoxypsoralen brands.
Topics: Adult; Body Weight; Humans; Methoxsalen; Pilot Projects | 1992 |
Hypocholesterolemic effect of khellin and methoxsalen in male albino rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Khellin; Lipoproteins; Male; Methoxsale | 1992 |
Toxicity of 8-methoxypsoralen in cynomolgous monkeys (Macaca fascicularis).
Topics: Animals; Blood Pressure; Body Weight; Eating; Electrocardiography; Female; Macaca fascicularis; Male | 1989 |
Toxicity of 8-methoxypsoralen, 5-methoxypsoralen, 3-carbethoxypsoralen, or 5-methylisopsoralen with ultraviolet radiation in the hairless (HRA/Skh) mouse.
Topics: 5-Methoxypsoralen; Animals; Body Weight; Eating; Female; Furocoumarins; Male; Methoxsalen; Mice; Mic | 1987 |
Method for testing the efficacy of topical sunscreen preparations.
Topics: Albinism; Animals; Body Weight; Male; Methods; Methoxsalen; Photosensitivity Disorders; Rats; Sunbur | 1968 |