methoxsalen and Bleb
methoxsalen has been researched along with Bleb in 18 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin." | 7.66 | Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978) |
| "Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA)." | 7.65 | Topical methoxsalen and blacklight in the treatment of psoriasis. ( Kaidbey, KM; Kligman, AM; Petrozzi, JW, 1977) |
| "Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin." | 3.66 | Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978) |
| "Thirty patients with recalcitrant psoriasis were treated with topical methoxsalen and blacklight (UVA)." | 3.65 | Topical methoxsalen and blacklight in the treatment of psoriasis. ( Kaidbey, KM; Kligman, AM; Petrozzi, JW, 1977) |
| "These blebs also displayed a high exposure of the antigens CD5 and CD8 as well as a low exposure of CD28 and CD86." | 1.35 | Photopheresis with UV-A light and 8-methoxypsoralen leads to cell death and to release of blebs with anti-inflammatory phenotype in activated and non-activated lymphocytes. ( Fietkau, R; Finzel, S; Frey, B; Gaipl, US; Herrmann, M; Hueber, A; Munoz, LE; Rech, J; Stadler, K, 2009) |
| "The photogenotoxicity of this suction blister fluid containing 5-methoxypsoralen and also other ingredients of the tanning preparation was assayed on yeast cells and was found to be rather low." | 1.29 | Evaluation of phototoxic and photogenotoxic risk associated with the use of photosensitizers in suntan preparations: application to tanning preparations containing bergamot oil. ( Averbeck, D; Dubertret, L; Morlière, P; Moysan, A, 1993) |
| "A suction blister technique, performed on the volar aspect of the forearm, permitted the collection of these two molecules." | 1.28 | Citropten and bergapten suction blister fluid concentrations after solar product application in man. ( Agache, P; Blanc, D; Faivre, B; Humbert, P; Makki, S; Treffel, P, 1991) |
| "Blisters were raised at three different times: 18 h prior to drug administration (group I); 2 h prior to drug administration (group II); and during drug ingestion (group III)." | 1.28 | Peak blistering point: influence on fluid levels of 5-MOP in human skin in vivo after systemic administration. ( Agache, P; Humbert, P; Makki, S; Millet, J; Treffel, P, 1991) |
| "A suction blister technique performed of the anterior aspect of the forearm permitted the collection of these two accumulated molecules." | 1.28 | High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans. ( Agache, P; Humbert, P; Makki, S; Treffel, P, 1991) |
| "Plasma and skin blister fluid levels of 8-MOP are determined 2 h following oral administration of 40-60 mg 8-MOP." | 1.26 | Determination of 8-methoxypsoralen levels in plasma and skin suction blister fluid by a new sensitive fluorodensitometric method. ( Korting, HC; Mutschler, E; Roser-Maass, E; Schäfer-Korting, M, 1982) |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Stadler, K | 1 |
| Frey, B | 1 |
| Munoz, LE | 1 |
| Finzel, S | 1 |
| Rech, J | 1 |
| Fietkau, R | 1 |
| Herrmann, M | 1 |
| Hueber, A | 1 |
| Gaipl, US | 1 |
| Huuskonen, H | 1 |
| Koulu, L | 1 |
| Wilén, G | 1 |
| Blais, J | 1 |
| Dubertret, L | 2 |
| Gaboriau, F | 1 |
| Vigny, P | 1 |
| Herfst, MJ | 2 |
| De Wolff, FA | 2 |
| Korting, HC | 1 |
| Schäfer-Korting, M | 2 |
| Roser-Maass, E | 1 |
| Mutschler, E | 1 |
| Lauharanta, J | 1 |
| Juvakoski, T | 1 |
| Kanerva, L | 1 |
| Lassus, A | 1 |
| Edelbroek, PM | 1 |
| Moysan, A | 1 |
| Morlière, P | 1 |
| Averbeck, D | 1 |
| Geary, P | 1 |
| Yeo, UC | 1 |
| Shin, JH | 1 |
| Yang, JM | 1 |
| Park, KB | 1 |
| Kim, MM | 1 |
| Bok, HS | 1 |
| Lee, ES | 1 |
| Hannuksela, M | 1 |
| Karvonen, J | 1 |
| Petrozzi, JW | 1 |
| Kaidbey, KM | 1 |
| Kligman, AM | 1 |
| Treffel, P | 3 |
| Makki, S | 3 |
| Faivre, B | 1 |
| Humbert, P | 3 |
| Blanc, D | 1 |
| Agache, P | 3 |
| Millet, J | 1 |
| Reymond, JL | 1 |
| Beani, JC | 1 |
| Racinet, H | 1 |
| Bonnot, D | 1 |
| Beriel, H | 1 |
| Amblard, P | 1 |
| Pibouin, M | 1 |
| Zini, R | 1 |
| Nguyen, P | 1 |
| Renouard, A | 1 |
| Tillement, JP | 1 |
Other Studies
18 other studies available for methoxsalen and Bleb
| Article | Year |
|---|---|
Photopheresis with UV-A light and 8-methoxypsoralen leads to cell death and to release of blebs with anti-inflammatory phenotype in activated and non-activated lymphocytes.
Topics: Antigens, Surface; Apoptosis; Blister; Cells, Cultured; Humans; Inflammation; Lymphocyte Activation; | 2009 |
Quantitative determination of methoxsalen in human serum, suction blister fluid and epidermis by gas chromatography mass spectrometry.
Topics: Blister; Gas Chromatography-Mass Spectrometry; Humans; Methoxsalen; Skin | 1984 |
Fluorescence detection of an 8-methoxypsoralen metabolite in human interstitial fluid.
Topics: Blister; Humans; Methoxsalen; Spectrometry, Fluorescence | 1982 |
Influenced of food on the kinetics of 8-methoxypsoralen in serum and suction blister fluid in psoriatic patients.
Topics: Blister; Food; Humans; Kinetics; Methoxsalen; Psoriasis; PUVA Therapy | 1982 |
Determination of 8-methoxypsoralen levels in plasma and skin suction blister fluid by a new sensitive fluorodensitometric method.
Topics: Adult; Aged; Blister; Densitometry; Exudates and Transudates; Female; Fluorometry; Humans; Male; Met | 1982 |
Pharmacokinetics of 8-methoxypsoralen in serum and suction blister fluid.
Topics: Blister; Kinetics; Methoxsalen; Photochemotherapy; Psoriasis; PUVA Therapy | 1982 |
Determination of 8-methoxypsoralen in suction-blister fluid and serum by liquid chromatography.
Topics: Blister; Chromatography, High Pressure Liquid; Humans; Kinetics; Methoxsalen; Psoriasis; Suction | 1980 |
Evaluation of phototoxic and photogenotoxic risk associated with the use of photosensitizers in suntan preparations: application to tanning preparations containing bergamot oil.
Topics: 5-Methoxypsoralen; Blister; Dermatitis, Phototoxic; Gas Chromatography-Mass Spectrometry; Humans; Me | 1993 |
Burns related to the use of psoralens as a tanning agent.
Topics: Adult; Blister; Burns; Female; Humans; Methoxsalen; Photosensitizing Agents; Skin Pigmentation; Sunb | 1996 |
Psoralen-ultraviolet A-induced erythema: sensitivity correlates with the concentrations of psoralen in suction blister fluid.
Topics: Adolescent; Adult; Blister; Erythema; Female; Humans; Male; Methoxsalen; Middle Aged; Predictive Val | 2000 |
Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis.
Topics: Adolescent; Adult; Aged; Baths; Blister; Dermatitis, Contact; Female; Furocoumarins; Humans; Male; M | 1978 |
Topical methoxsalen and blacklight in the treatment of psoriasis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Blister; Child; Female; Humans; Male; Methoxsalen; | 1977 |
Citropten and bergapten suction blister fluid concentrations after solar product application in man.
Topics: 5-Methoxypsoralen; Administration, Topical; Adult; Blister; Chromatography, High Pressure Liquid; Co | 1991 |
Peak blistering point: influence on fluid levels of 5-MOP in human skin in vivo after systemic administration.
Topics: 5-Methoxypsoralen; Adult; Blister; Exudates and Transudates; Humans; Male; Methoxsalen; Skin | 1991 |
High-performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans.
Topics: 5-Methoxypsoralen; Adult; Blister; Chromatography, High Pressure Liquid; Coumarins; Exudates and Tra | 1991 |
Comparative pharmacokinetics of 8-MOP in serum and in suction blister fluid.
Topics: Adult; Aged; Aged, 80 and over; Blister; Female; Humans; Male; Methoxsalen; Middle Aged; Psoriasis; | 1988 |
Binding of 8-methoxypsoralen to human serum proteins and red blood cells.
Topics: Binding Sites; Blister; Blood Proteins; Diazepam; Erythrocytes; Erythromycin; Humans; Indomethacin; | 1987 |
[Penetration of 8-methoxypsoralen into suction blister fluid in the rat].
Topics: Animals; Blister; Body Fluids; Male; Methoxsalen; Rats; Rats, Inbred Strains | 1985 |