methoxsalen has been researched along with Anemia, Fanconi in 24 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The partial phenotypic correction of the two end points examined is interpreted as indicating either a gene dosage effect or the necessity of introducing more than one gene type in order to achieve complete recovery of a normal phenotype." | 1.28 | Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents. ( Diatloff-Zito, C; Heddle, J; Moustacchi, E; Rosselli, F, 1990) |
| "Five homozygous patients with Fanconi's anemia and nine heterozygous relatives were studied for mutagen sensitivity by a new method." | 1.27 | Response of lymphocytes from Fanconi's anemia patients and their heterozygous relatives to 8-methoxy-psoralene in a cloning survival test system. ( Fleischer-Reischmann, B; Wunder, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voter, AF | 1 |
| Manthei, KA | 1 |
| Keck, JL | 1 |
| Poll, EH | 1 |
| Arwert, F | 1 |
| Kortbeek, HT | 1 |
| Eriksson, AW | 1 |
| Wunder, E | 2 |
| Fleischer-Reischmann, B | 1 |
| Rosselli, F | 2 |
| Duchaud, E | 1 |
| Averbeck, D | 3 |
| Moustacchi, E | 11 |
| Bredberg, A | 1 |
| Sandor, Z | 1 |
| Brant, M | 1 |
| Matsumoto, A | 1 |
| Fujiwara, Y | 1 |
| Elespuru, RK | 1 |
| Hanawalt, PC | 1 |
| Rousset, S | 3 |
| Nocentini, S | 3 |
| Santella, RM | 1 |
| Gasparro, FP | 1 |
| Centurion, SA | 1 |
| Kuo, HR | 1 |
| Lambert, WC | 2 |
| Rouillard, D | 1 |
| Baroche, C | 1 |
| Lambert, MW | 1 |
| Tsongalis, GJ | 1 |
| Hang, B | 1 |
| Parrish, DD | 1 |
| Sun, Y | 1 |
| Moses, RE | 1 |
| Papadopoulo, D | 4 |
| Porfirio, B | 1 |
| Diatloff-Zito, C | 4 |
| Heddle, J | 1 |
| Revet, B | 1 |
| Digweed, M | 2 |
| Sperling, K | 2 |
| Dean, SW | 1 |
| Zakrzewski-Lüdcke, S | 1 |
| Gök, MM | 1 |
| Billardon, B | 1 |
| Buchwald, M | 1 |
| Gruenert, DC | 1 |
| Kapp, LN | 1 |
| Cleaver, JE | 1 |
24 other studies available for methoxsalen and Anemia, Fanconi
| Article | Year |
|---|---|
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc | 2016 |
Fanconi anaemia cells are not uniformly deficient in unhooking of DNA interstrand crosslinks, induced by mitomycin C or 8-methoxypsoralen plus UVA.
Topics: Cell Line; Cross-Linking Reagents; DNA Repair; Fanconi Anemia; Furocoumarins; Humans; Methoxsalen; M | 1984 |
Response of lymphocytes from Fanconi's anemia patients and their heterozygous relatives to 8-methoxy-psoralene in a cloning survival test system.
Topics: Adolescent; Adult; Anemia, Aplastic; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; F | 1983 |
Comparison of the effects of DNA topoisomerase inhibitors on lymphoblasts from normal and Fanconi anemia donors.
Topics: Camptothecin; Cell Division; Cells, Cultured; Chromosome Aberrations; DNA; DNA Damage; DNA Repair; F | 1994 |
Mutational response of Fanconi anaemia cells to shuttle vector site-specific psoralen cross-links.
Topics: Base Sequence; Cell Line; DNA; DNA Adducts; DNA Mutational Analysis; DNA Repair; Fanconi Anemia; Gen | 1995 |
Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and dihydrofolate reductase.
Topics: Aminoglycosides; Anti-Bacterial Agents; Blotting, Southern; Cell Line; Cell Survival; Coumarins; DNA | 1994 |
Immunological probing of induction and repair of 8-methoxypsoralen photoadducts in DNA from Fanconi anemia and normal human fibroblasts: quantitative analysis by electron microscopy.
Topics: Cell Line; DNA; DNA Repair; Dose-Response Relationship, Radiation; Fanconi Anemia; Fibroblasts; Huma | 1993 |
Damage-resistant DNA synthesis in Fanconi anemia cells treated with a DNA cross-linking agent.
Topics: Cell Cycle Proteins; Cell Line; Cross-Linking Reagents; DNA; DNA Adducts; DNA Damage; DNA Replicatio | 2000 |
Mitochondrial alterations in fanconi anemia fibroblasts following ultraviolet A or psoralen photoactivation.
Topics: Cell Line; Fanconi Anemia; Fibroblasts; Furocoumarins; Humans; Methoxsalen; Mitochondria; Oxygen; Ph | 2002 |
Defective DNA endonuclease activities in Fanconi's anemia cells, complementation groups A and B.
Topics: Cell Line; Densitometry; Deoxyribonucleases; DNA; DNA Repair; Fanconi Anemia; Ficusin; Furocoumarins | 1992 |
Reactivation of psoralen-reacted plasmid DNA in Fanconi anemia, xeroderma pigmentosum, and normal human fibroblast cells.
Topics: Cell Line, Transformed; Cell Survival; Chloramphenicol O-Acetyltransferase; Cross-Linking Reagents; | 1991 |
Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens.
Topics: Anemia, Aplastic; Cell Survival; Fanconi Anemia; Furocoumarins; Humans; Hypoxanthine Phosphoribosylt | 1990 |
Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents.
Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cross-Linking Reagents; DNA; Drug Resista | 1990 |
Molecular analysis by electron microscopy of the removal of psoralen-photoinduced DNA cross-links in normal and Fanconi's anemia fibroblasts.
Topics: Anemia, Aplastic; Cells, Cultured; DNA; Dose-Response Relationship, Radiation; Fanconi Anemia; Fibro | 1990 |
Identification of a HeLa mRNA fraction which can correct the DNA-repair defect in Fanconi anaemia fibroblasts.
Topics: Adenine; Anemia, Aplastic; Cell Line; Child, Preschool; Cross-Linking Reagents; DNA; DNA Repair; Fan | 1989 |
Repair of 8-methoxypsoralen + UVA-induced damage in specific sequences in chromosomal and episomal DNA in human cells.
Topics: Cell Line; Cell Transformation, Neoplastic; DNA; DNA Damage; DNA Repair; Fanconi Anemia; Genes; Huma | 1989 |
Abnormal response to DNA crosslinking agents of Fanconi anemia fibroblasts can be corrected by transfection with normal human DNA.
Topics: Anemia, Aplastic; Base Sequence; Cell Line; Cross-Linking Reagents; DNA; Drug Resistance; Fanconi An | 1986 |
Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response.
Topics: Anemia, Aplastic; Cell Line; DNA Repair; Fanconi Anemia; Genetic Complementation Test; Humans; Metho | 1988 |
Microinjection of normal cell extracts into Fanconi anemia fibroblasts corrects defective scheduled DNA synthesis recovery after 8-methoxypsoralen plus UVa treatment.
Topics: Anemia, Aplastic; Cells, Cultured; Child; DNA Damage; DNA Repair; Fanconi Anemia; Female; Humans; In | 1987 |
The fate of 8-methoxypsoralen-photoinduced DNA interstrand crosslinks in Fanconi's anemia cells of defined genetic complementation groups.
Topics: Anemia, Aplastic; Cell Line; Cell Survival; Cross-Linking Reagents; DNA Damage; DNA Repair; Fanconi | 1987 |
Comparison of the sensitivity of Fanconi's anemia and normal fibroblasts to the induction of sister-chromatid exchanges by photoaddition of mono- and bi-functional psoralens.
Topics: Anemia, Aplastic; Cells, Cultured; Cross-Linking Reagents; Fanconi Anemia; Fibroblasts; Furocoumarin | 1986 |
Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment.
Topics: Anemia, Aplastic; Cells, Cultured; Cross-Linking Reagents; DNA; Fanconi Anemia; Fibroblasts; Humans; | 1987 |
Inhibition of DNA synthesis by psoralen-induced lesions in xeroderma pigmentosum and Fanconi's anemia fibroblasts.
Topics: Anemia, Aplastic; Cell Line; DNA Replication; Fanconi Anemia; Humans; Methoxsalen; Ultraviolet Rays; | 1985 |
DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays.
Topics: Adolescent; Adult; Anemia, Aplastic; Cell Line; Child; Child, Preschool; DNA; DNA Repair; Fanconi An | 1985 |