methoxsalen has been researched along with Anemia, Aplastic in 13 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five homozygous patients with Fanconi's anemia and nine heterozygous relatives were studied for mutagen sensitivity by a new method." | 1.27 | Response of lymphocytes from Fanconi's anemia patients and their heterozygous relatives to 8-methoxy-psoralene in a cloning survival test system. ( Fleischer-Reischmann, B; Wunder, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wunder, E | 2 |
| Fleischer-Reischmann, B | 1 |
| Papadopoulo, D | 4 |
| Porfirio, B | 1 |
| Moustacchi, E | 7 |
| Rousset, S | 1 |
| Nocentini, S | 1 |
| Revet, B | 1 |
| Digweed, M | 2 |
| Sperling, K | 2 |
| Diatloff-Zito, C | 3 |
| Averbeck, D | 2 |
| Zakrzewski-Lüdcke, S | 1 |
| Gök, MM | 1 |
| Billardon, B | 1 |
| Buchwald, M | 1 |
| Gruenert, DC | 1 |
| Kapp, LN | 1 |
| Cleaver, JE | 1 |
| Sasaki, MS | 1 |
| Tonomura, A | 1 |
13 other studies available for methoxsalen and Anemia, Aplastic
| Article | Year |
|---|---|
Response of lymphocytes from Fanconi's anemia patients and their heterozygous relatives to 8-methoxy-psoralene in a cloning survival test system.
Topics: Adolescent; Adult; Anemia, Aplastic; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; F | 1983 |
Mutagenic response of Fanconi's anemia cells from a defined complementation group after treatment with photoactivated bifunctional psoralens.
Topics: Anemia, Aplastic; Cell Survival; Fanconi Anemia; Furocoumarins; Humans; Hypoxanthine Phosphoribosylt | 1990 |
Molecular analysis by electron microscopy of the removal of psoralen-photoinduced DNA cross-links in normal and Fanconi's anemia fibroblasts.
Topics: Anemia, Aplastic; Cells, Cultured; DNA; Dose-Response Relationship, Radiation; Fanconi Anemia; Fibro | 1990 |
Identification of a HeLa mRNA fraction which can correct the DNA-repair defect in Fanconi anaemia fibroblasts.
Topics: Adenine; Anemia, Aplastic; Cell Line; Child, Preschool; Cross-Linking Reagents; DNA; DNA Repair; Fan | 1989 |
Abnormal response to DNA crosslinking agents of Fanconi anemia fibroblasts can be corrected by transfection with normal human DNA.
Topics: Anemia, Aplastic; Base Sequence; Cell Line; Cross-Linking Reagents; DNA; Drug Resistance; Fanconi An | 1986 |
Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response.
Topics: Anemia, Aplastic; Cell Line; DNA Repair; Fanconi Anemia; Genetic Complementation Test; Humans; Metho | 1988 |
Microinjection of normal cell extracts into Fanconi anemia fibroblasts corrects defective scheduled DNA synthesis recovery after 8-methoxypsoralen plus UVa treatment.
Topics: Anemia, Aplastic; Cells, Cultured; Child; DNA Damage; DNA Repair; Fanconi Anemia; Female; Humans; In | 1987 |
The fate of 8-methoxypsoralen-photoinduced DNA interstrand crosslinks in Fanconi's anemia cells of defined genetic complementation groups.
Topics: Anemia, Aplastic; Cell Line; Cell Survival; Cross-Linking Reagents; DNA Damage; DNA Repair; Fanconi | 1987 |
Comparison of the sensitivity of Fanconi's anemia and normal fibroblasts to the induction of sister-chromatid exchanges by photoaddition of mono- and bi-functional psoralens.
Topics: Anemia, Aplastic; Cells, Cultured; Cross-Linking Reagents; Fanconi Anemia; Fibroblasts; Furocoumarin | 1986 |
Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment.
Topics: Anemia, Aplastic; Cells, Cultured; Cross-Linking Reagents; DNA; Fanconi Anemia; Fibroblasts; Humans; | 1987 |
Inhibition of DNA synthesis by psoralen-induced lesions in xeroderma pigmentosum and Fanconi's anemia fibroblasts.
Topics: Anemia, Aplastic; Cell Line; DNA Replication; Fanconi Anemia; Humans; Methoxsalen; Ultraviolet Rays; | 1985 |
DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays.
Topics: Adolescent; Adult; Anemia, Aplastic; Cell Line; Child; Child, Preschool; DNA; DNA Repair; Fanconi An | 1985 |
A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.
Topics: Alkanesulfonates; Alkylating Agents; Anemia, Aplastic; Antimetabolites; Caffeine; Cell Division; Cel | 1973 |