methoxsalen has been researched along with Abnormalities, Autosome in 29 studies
Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0159 microg/mL with UV) while CLZ was negative up to a toxic concentration of 35 microg/mL." | 1.31 | Photoclastogenicity-an improved protocol, its validation, and investigation of the photogenotoxicity of DMBA. ( Aardema, M; Lawlor, T; Murli, H; Spicer, C, 2002) |
| "The number of chromosomal aberrations and SCE were increased upon treatment, but only transiently, returning to basal levels between consecutive treatments." | 1.28 | Cytogenetic effects during extracorporeal photopheresis treatment of two patients with cutaneous T-cell lymphoma. ( Gebauer, HJ; Küster, W; Meschig, R; Peterseim, UM; Plewig, G, 1991) |
| " The partial phenotypic correction of the two end points examined is interpreted as indicating either a gene dosage effect or the necessity of introducing more than one gene type in order to achieve complete recovery of a normal phenotype." | 1.28 | Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents. ( Diatloff-Zito, C; Heddle, J; Moustacchi, E; Rosselli, F, 1990) |
| "Here we report the types of chromosomal aberrations produced by re-irradiation and, hence, by DNA crosslinks." | 1.27 | On the types of chromosomal aberrations induced by 8-methoxypsoralen. ( Heddle, JA; Hook, GJ; Marshall, RR, 1983) |
| "The induction of structural chromosome aberrations and sister chromatid exchanges (SCE) was studied in human lymphocytes in vitro after treatment with the two bifunctional furocoumarins 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) in the presence of UV-A." | 1.27 | Chromosome damage induced in human lymphocytes by 5-methoxypsoralen and 8-methoxypsoralen plus UV-A. ( Abel, G, 1987) |
| "The localization of the chromosome aberrations was nonrandom." | 1.26 | Psoralen/UVA treatment and chromosomes. I. Aberrations and sister chromatid exchange in human lymphocytes in vitro and synergism with caffeine. ( Brogger, A; Stene, J; Waksvik, H, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (62.07) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dufour, EK | 2 |
| Whitwell, J | 1 |
| Nohynek, GJ | 2 |
| Kirkland, D | 2 |
| Toutain, H | 2 |
| Murli, H | 1 |
| Aardema, M | 1 |
| Lawlor, T | 1 |
| Spicer, C | 1 |
| Kumaravel, T | 1 |
| Liu-Lee, VW | 1 |
| Heddle, JA | 2 |
| Arlett, CF | 1 |
| Broughton, B | 1 |
| Hook, GJ | 1 |
| Marshall, RR | 1 |
| Wulf, HC | 1 |
| Bredberg, A | 3 |
| Ashwood-Smith, MJ | 1 |
| Poulton, GA | 1 |
| Chételat, A | 1 |
| Dresp, JH | 1 |
| Gocke, E | 2 |
| Youssefi, AA | 1 |
| Arutyunyan, R | 1 |
| Emerit, I | 1 |
| Rosselli, F | 2 |
| Duchaud, E | 1 |
| Averbeck, D | 1 |
| Moustacchi, E | 2 |
| Chételat, AA | 1 |
| Albertini, S | 1 |
| Swanbeck, G | 1 |
| Thyresson-Hök, M | 1 |
| Lambert, B | 1 |
| Shuler, CF | 1 |
| Latt, SA | 1 |
| Omar, A | 2 |
| Wiesmann, UN | 2 |
| Krebs, A | 2 |
| Wagner, J | 1 |
| Manthorpe, R | 1 |
| Philip, P | 1 |
| Frost, F | 1 |
| Wolff-Schreiner, EC | 1 |
| Carter, DM | 1 |
| Schwarzacher, HG | 1 |
| Wolff, K | 1 |
| Waksvik, H | 1 |
| Brogger, A | 1 |
| Stene, J | 1 |
| Sage, E | 1 |
| Peterseim, UM | 1 |
| Küster, W | 1 |
| Gebauer, HJ | 1 |
| Meschig, R | 1 |
| Plewig, G | 1 |
| Makedonov, GP | 1 |
| Chekova, VV | 1 |
| Yakubovskaya, EL | 1 |
| Zasukhina, GD | 2 |
| Diatloff-Zito, C | 1 |
| Heddle, J | 1 |
| Makedonov, GN | 1 |
| Iakubovskaia, EL | 1 |
| Abel, G | 2 |
| Mannschedel, A | 1 |
| Lee, TC | 1 |
| Lee, KC | 1 |
| Tzeng, YJ | 1 |
| Huang, RY | 1 |
| Jan, KY | 1 |
| Sasaki, MS | 1 |
| Tonomura, A | 1 |
| Nicoletti, B | 1 |
| Paggini, L | 1 |
| Colombo, G | 1 |
29 other studies available for methoxsalen and Abnormalities, Autosome
| Article | Year |
|---|---|
Retinyl palmitate is non-genotoxic in Chinese hamster ovary cells in the dark or after pre-irradiation or simultaneous irradiation with UV light.
Topics: Animals; Antioxidants; CHO Cells; Chromosome Aberrations; Comet Assay; Cricetinae; Diterpenes; DNA D | 2009 |
Photoclastogenicity-an improved protocol, its validation, and investigation of the photogenotoxicity of DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chlorpromazine; CHO Cells; Chromosome Aberrations; Cricet | 2002 |
Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Chromosome Aberrations; Cricetinae; Dose-Response Relationship, Drug; Dose-Respo | 2006 |
Genetic effects of specific DNA lesions in mammalian cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromosome Aberrations; Cross-Linking Reagents; Crossing Ove | 1984 |
On the types of chromosomal aberrations induced by 8-methoxypsoralen.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Methoxsalen; Mice; Photochemistry; Time Factors; U | 1983 |
Aspects of the toxicology of 8-methoxypsoralen and longwave ultraviolet light.
Topics: Animals; Autoradiography; Chromosome Aberrations; Chromosomes; DNA; Humans; Lymphocytes; Methoxsalen | 1982 |
Genetic toxicity of psoralen and ultraviolet radiation in human cells.
Topics: Animals; Chromosome Aberrations; DNA; Female; Fibroblasts; Genes; Germ Cells; Humans; In Vitro Techn | 1982 |
Inappropriate regulations governing the use of oil of bergamot in suntan preparations.
Topics: 5-Methoxypsoralen; Animals; Carcinogens; Chromosome Aberrations; Dose-Response Relationship, Drug; H | 1981 |
Photomutagenesis test development: II. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells.
Topics: Animals; Chlorpromazine; CHO Cells; Chromosome Aberrations; Cricetinae; Methoxsalen; Mutagenesis; Mu | 1993 |
Chromosome damage in PUVA-treated human lymphocytes is related to active oxygen species and clastogenic factors.
Topics: 5-Methoxypsoralen; Cells, Cultured; Chromosome Aberrations; Ethanol; Humans; Kinetics; Lymphocytes; | 1994 |
Comparison of the effects of DNA topoisomerase inhibitors on lymphoblasts from normal and Fanconi anemia donors.
Topics: Camptothecin; Cell Division; Cells, Cultured; Chromosome Aberrations; DNA; DNA Damage; DNA Repair; F | 1994 |
The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay).
Topics: Animals; Anti-Infective Agents; Carcinogens; Chromosome Aberrations; Ciprofloxacin; Cricetinae; DNA | 1996 |
Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Therapeutic results and cytogenetic hazards.
Topics: Administration, Oral; Adult; Chromosome Aberrations; Female; Humans; Leukocytes; Male; Methoxsalen; | 1975 |
Sister chromatid exchange induction resulting from systemic, topical, and systemic-topical presentations of carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Bone Marrow; Carcinogens; Chroma | 1979 |
Polyploidization and hemiploidization induced by PUVA in vivo.
Topics: Cell Division; Cell Nucleus; Chromosome Aberrations; Epidermis; Fibroblasts; Humans; Meiosis; Methox | 1979 |
Preleukaemia (haemopoietic dysplasia) developing in a patient with psoriasis treated with 8-methoxypsoralen and ultraviolet light (PUVA treatment).
Topics: Aged; Blood Cell Count; Bone Marrow; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Humans; | 1978 |
Induction of multinucleate cells by 8-MOP and UV treatment in vitro and in vivo.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Chromosome Aberrations; Fibroblasts; Humans; Methoxsal | 1977 |
Sister chromatid exchanges in photochemotherapy.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anthralin; Child; Chromatids; Chromosome Aberrations; DNA Repa | 1977 |
Psoralen/UVA treatment and chromosomes. I. Aberrations and sister chromatid exchange in human lymphocytes in vitro and synergism with caffeine.
Topics: Caffeine; Chromatids; Chromosome Aberrations; Chromosomes, Human; Coumarins; Drug Synergism; Female; | 1977 |
Damage distribution and mutation spectrum: the case of 8-methoxypsoralen plus UVA in mammalian cells.
Topics: Animals; Base Composition; Base Sequence; Cell Line; Chromosome Aberrations; DNA Damage; DNA Repair; | 1991 |
Cytogenetic effects during extracorporeal photopheresis treatment of two patients with cutaneous T-cell lymphoma.
Topics: Administration, Oral; Aged; Chromosome Aberrations; Female; Humans; Lymphocytes; Lymphoma, T-Cell, C | 1991 |
Modification of DNA repair by human interferons.
Topics: 4-Nitroquinoline-1-oxide; Chromosome Aberrations; DNA Repair; Fast Neutrons; Gamma Rays; Humans; In | 1990 |
Partial complementation of the Fanconi anemia defect upon transfection by heterologous DNA. Phenotypic dissociation of chromosomal and cellular hypersensitivity to DNA cross-linking agents.
Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cross-Linking Reagents; DNA; Drug Resista | 1990 |
[Mechanism of action of interferon is linked to its ability to protect the cell from interstrand cross-linking of DNA, induced by 8-methoxypsoralen, activated by long-wave UV-light].
Topics: Chromosome Aberrations; DNA; Humans; Interferon Type I; Interphase; Lymphocytes; Methoxsalen; Mutati | 1989 |
The clastogenic effect of 5-methoxypsoralen plus UV-A in human lymphocytes in vitro and its modification by the anticlastogen beta-aminoethylisothiouronium.
Topics: 5-Methoxypsoralen; beta-Aminoethyl Isothiourea; Chromosome Aberrations; Humans; Lymphocytes; Methoxs | 1987 |
Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA crosslinking agents.
Topics: Animals; Arsenic; Arsenites; Cell Division; Cells, Cultured; Chromosome Aberrations; Cisplatin; Coca | 1986 |
Chromosome damage induced in human lymphocytes by 5-methoxypsoralen and 8-methoxypsoralen plus UV-A.
Topics: 5-Methoxypsoralen; Cell Division; Cells, Cultured; Chromosome Aberrations; Humans; Lymphocytes; Meta | 1987 |
A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.
Topics: Alkanesulfonates; Alkylating Agents; Anemia, Aplastic; Antimetabolites; Caffeine; Cell Division; Cel | 1973 |
[Action of photoactivated 8-methoxypsoralen on human amnion cells cultured in vitro].
Topics: Amnion; Chromosome Aberrations; Chromosomes; Culture Techniques; Humans; Methoxsalen; Radiation Effe | 1967 |