Compounds > methoxamine
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methoxamine and Bowel Incontinence

methoxamine has been researched along with Bowel Incontinence in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bush, D; Gruss, HJ; Jacobs, A; Pediconi, C; Scholefield, JH; Simpson, JA1
Bell, D; Jacobs, A; Pediconi, C1
Bell, D; Duffin, A; Gruss, HJ; Jacobs, A; Pediconi, C1
Jones, D; Scholefield, JH; Shing, RN; Siproudhis, L; Walker, D1
Emmanuel, A; Graf, W; Pediconi, C; Pilot, J; Scholefield, J; Shing, RN; Siproudhis, L; Walker, D; Wexner, S1
Acheson, AG; Bush, D; Gruss, HJ; Nisar, PJ; Scholefield, JH1

Trials

5 trial(s) available for methoxamine and Bowel Incontinence

ArticleYear
A randomised, controlled, crossover study to investigate the safety and response of 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16 Suppl 1

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Anal Canal; Cross-Over Studies; Double-Blind Method; Fecal Incontinence; Female; Healthy Volunteers; Heart Rate; Humans; Male; Methoxamine; Middle Aged; Stereoisomerism; Suppositories

2014
Randomised clinical trial: study of escalating doses of NRL001 given in rectal suppositories of different weights.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16 Suppl 1

    Topics: Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Double-Blind Method; Fecal Incontinence; Female; Humans; Male; Methoxamine; Middle Aged; Suppositories

2014
A double-blind, placebo-controlled, randomised, parallel-group, dose-escalating, repeat dose study in healthy volunteers to evaluate the safety, tolerability, pharmacodynamic effects and pharmacokinetics of the once daily rectal application of NRL001 supp
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16 Suppl 1

    Topics: Administration, Rectal; Adolescent; Adrenergic alpha-1 Receptor Agonists; Adult; Double-Blind Method; Drug Tolerance; Electrocardiography; Electrocardiography, Ambulatory; Fecal Incontinence; Female; Heart Rate; Humans; Male; Methoxamine; Middle Aged; Stereoisomerism; Suppositories; Vital Signs

2014
Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16 Suppl 1

    Topics: Adrenergic alpha-1 Receptor Agonists; Double-Blind Method; Drug Tolerance; Fecal Incontinence; Methoxamine; Patient Satisfaction; Stereoisomerism; Suppositories; Treatment Outcome

2014
Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response.
    International journal of colorectal disease, 2016, Volume: 31, Issue:6

    Topics: Demography; Fecal Incontinence; Female; Humans; Male; Methoxamine; Middle Aged; Patient Satisfaction; Placebos; Quality of Life; Surveys and Questionnaires; Treatment Outcome

2016

Other Studies

1 other study(ies) available for methoxamine and Bowel Incontinence

ArticleYear
Intra-anal application of L-erythro methoxamine gel increases anal resting pressure in patients with incontinence.
    The British journal of surgery, 2007, Volume: 94, Issue:9

    Topics: Administration, Rectal; Adrenergic alpha-Agonists; Adult; Aged; Anal Canal; Blood Pressure; Fecal Incontinence; Female; Gels; Humans; Male; Methoxamine; Middle Aged; Pressure; Pulse; Treatment Outcome

2007