Compounds > methotrexate
Page last updated: 2024-08-25

methotrexate and Seizures

methotrexate has been researched along with Seizures in 71 studies

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-199031 (43.66)18.7374
1990's10 (14.08)18.2507
2000's14 (19.72)29.6817
2010's12 (16.90)24.3611
2020's4 (5.63)2.80

Authors

AuthorsStudies
Als-Nielsen, B; Anastasopoulou, S; Banerjee, J; Eriksson, MA; Harila-Saari, A; Helenius, M; Heyman, MM; Johannsdottir, IM; Jonsson, OG; MacGregor, S; Mateos, MK; Mayoh, C; Mikkel, S; Myrberg, IH; Nielsen, RL; Niinimäki, R; Ranta, S; Schmiegelow, K; Taskinen, M; Vaitkeviciene, G; Warnqvist, A; Wolthers, B1
Barreto, JN; Buddington, RK; Combs, R; Guscott, M; Heldrup, J; Howard, SC; Hurmiz, C; Ibarra, M; Lowe, J; Marada, S; Mikkelsen, T; Ramsey, LB; Schaiquevich, P; Taylor, ZL1
Ding, CH; Fang, F; Feng, WX; Ge, M; Gong, S; Li, JW; Xiang, X; Zhang, N; Zhuo, XW1
Grinenko, O; Karanec, K; Tolla, AS; Young, G1
Felice, MS; Guitter, MR; Millan, NC; Monges, MS; Pastrana, A; Zubizarreta, PA1
Anderson, LE; Knight, AM; Kreiger, PA; Licht, DJ; Treat, JR1
Escherich, G; Hagel, C; Hartz, B; Löbel, U1
Frenel, JS; Nowak, C; Philippe, HJ; Sagan, C; Tardif, C1
Biemond, BJ; Cornelissen, JJ; Coutinho, JM; Lauw, MN; Majoie, CB; Middeldorp, S; Stam, J; van der Holt, B; Zuurbier, SM1
Horovitz, Y; Lidar, M1
Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW1
Ashford, JM; Cheng, C; Conklin, HM; Glass, JO; Jeha, S; Laningham, FH; Nassar, SL; Pui, CH; Reddick, WE; Zhou, Y1
Aboian, MS; Junna, MR; Krecke, KN; Wirrell, EC1
Dabbagh, O; El-Bitar, MK; Muwakkit, SA1
Ardura, MI; Harker-Murray, P; Johnson-Welch, SF; Pokala, H; Seikaly, M; Twombley, K; Weinberg, A1
Chastagner, P; Contet, A; Mansuy, L; Parentelli, AS; Phulpin-Weibel, A; Trechot, P1
Bagot, M; Bezier, M; Cordoliani, F; Crickx, B; Flageul, B; Moulonguet, I; Petit, A; Vignon-Pennamen, MD; Vuong, V1
CROCCO, J; DIBENEDETTO, R; KOMNINOS, ZD; SOSCIA, JL1
BOWERMAN, DL; GREENHOUSE, AH; NEUBUERGER, KT1
Fernandes, AS; Fonseca, RP; Leite, EB; Lima, VS1
Leng, XM; Zhang, FC; Zhou, HQ1
Fischer, L; Korfel, A; Ransco, C; Stoltenburg-Didinger, G; Thiel, E1
Avila, TT; Fischer, A; Jorge, RS; Leke, R; Oliveira, DL; Portela, LV; Schmidt, AP; Souza, DO; Wofchuk, S1
Tollefson, MM; Witman, PM1
Cabanillas, M; Ferrajoli, A; Garcia-Manero, G; Jabbour, E; Kantarjian, H; O'Brien, S; Ravandi, F; Thomas, DA1
Angelov, L; Diglaw, T; Fazio, V; Franic, L; Granata, T; Hallene, K; Hernandez, N; Janigro, D; Marchi, N; Masaryk, T; Najm, I1
Beneyto, P; García-Aparicio, AM; Leal, MA; Platero, M1
Chamberlain, MC; Glantz, MJ1
Aricò, M; Egeler, RM; Filipovich, AH; Gadner, H; Henter, JI; Horne, A; Imashuku, S; Janka, G; Ladisch, S; Trottestam, H; Webb, D1
Barnett, GH; Bhatia, J; Deogaonkar, A; Ebrahim, Z; Elkassabany, NM; Farag, E; Ference, S; Lotto, M; Maurtua, M; Schubert, A1
Hanefeld, F; Riehm, H1
Bennett, MJ; Frenkel, EP; Haines, JE; Hill, SA; Howieson, J; Neuwelt, EA; Specht, HD1
Coll de Tuero, G; Matías-Guiu Guía, J; Rodríguez Jornet, A1
Albani, F; Baruzzi, A; Bollini, C; Bollini, P; Cacciari, L; Ida, N; Riva, R1
Eviatar, L; Grossman, R; Karayalycin, G; Lanzkowsky, P; Maytal, J; Schaul, N; Shende, AC; Yusuf, FH1
Blotman, F; Hellier, JP; Leroux, JL; Thomas, E1
Chauveinc, L; Follezou, JY; Guerin, JM1
Shak, AK1
Fong, KW; Lee, AC; So, KT; Wong, KW1
Kokontis, L; Malanga, CJ; Mauzy, S1
Kelkar, P; Lövblad, K; Ozdoba, C; Ramelli, G; Remonda, L; Schroth, G1
Dziuba, J; Kleinrok, Z; Saczonek, J; Sieklucka-Dziuba, M1
Balmaceda, C; Mansukhani, M; Mears, JG; Orazi, A; Rescigno, J; Savage, DG; Shendrik, I1
DeAngelis, LM1
Eden, OB; Etcubanas, E; Goldie, W; Wood, T1
Ludwig, R; Meyer, E1
Terheggen, HG1
Evans, AE; Meadows, AT1
Gilles, FH; Merker, PC; Shepard, RF; Walker, MD1
Aspnes, GT; Kalavsky, SM; Kammerer, BL; Klatskin, EH; McIntosh, S; O'Brien, RT; Pearson, HA; Snead, C1
George, D; Paserchia, L; Weisberg, J1
Alfon, J; Hoffman, A1
Kramer, ED; Lewis, D; Packer, RJ; Raney, B; Womer, R1
Adair, S; Camitta, B; Casper, J; Civin, C; Graham, M; Lauer, S; Leventhal, B; Mahoney, D; Munoz, L; Shuster, JJ1
Di Bella, D; Lo Bianco, M; Rizzari, C; Russo, A; Schilirò, G1
Abromowitch, M; Dahl, GV; George, SL; Kalwinsky, DK; Look, AT; Mirro, J; Ochs, JJ; Pui, CH; Rivera, GK; Williams, D1
Allen, JC; Caparros, B; Rosen, G; Walker, RW1
Hirose, M; Miyao, M; Ninomiya, T; Sato, J; Tanaka, H; Yuasa, Y1
Acton, RT; Alarcón, GS; Barger, BO; Gispen, JG; Johnson, JJ; Koopman, WJ1
Johnston, MV; Silverstein, FS1
Balis, FM; Bleyer, WA; Poplack, DG; Reaman, GH; Savitch, JL1
Djerassi, I; Kim, JS; Reggev, A1
Beschorner, WE; Clark, AW; Patchell, RA; Santos, GW; White, CL1
Hommes, OR; Obbens, EA1
Baron, C; Laborit, G; Laborit, H; Laurent, J1
Ceci, A; Mitolo-chieppa, D1
Casadei, AM; Del Principe, D; Digilio, G; Iannetti, P; Multari, G1
Armata, J1
Adeloye, A; Hendrickse, JP; Odeku, EL; Osuntokun, BO1
Spector, RG1
Carlisle, H; Spector, RG1

Reviews

5 review(s) available for methotrexate and Seizures

ArticleYear
Remission of seizures with immunosuppressive therapy in Parry-Romberg syndrome and en coup de sabre linear scleroderma: Case report and brief review of the literature.
    Pediatric dermatology, 2018, Volume: 35, Issue:6

    Topics: Brain; Child; Facial Hemiatrophy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Remission Induction; Scleroderma, Localized; Seizures; Skin

2018
Intrathecal methotrexate overdose.
    Acta paediatrica (Oslo, Norway : 1992), 1997, Volume: 86, Issue:4

    Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Drug Overdose; Female; Humans; Injections, Spinal; Male; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Time Factors

1997
Leptomeningeal relapse of multiple myeloma following allogeneic stem cell transplantation.
    Leukemia research, 2002, Volume: 26, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Combined Modality Therapy; Dexamethasone; Diphosphonates; Doxorubicin; Fatal Outcome; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Factors; Immunosuppressive Agents; Interleukin-2; Melphalan; Meninges; Methotrexate; Multiple Myeloma; Neoplastic Stem Cells; Osteolysis; Pamidronate; Paraparesis; Recurrence; Salvage Therapy; Seizures; Transplantation Conditioning; Transplantation, Homologous; Vincristine

2002
Primary central nervous system lymphomas.
    Current treatment options in oncology, 2001, Volume: 2, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Combined Modality Therapy; Contraindications; Cranial Irradiation; Craniotomy; Diagnostic Imaging; Eye; Humans; Injections, Spinal; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Meninges; Methotrexate; Middle Aged; Neoplasm Invasiveness; Seizures; Stereotaxic Techniques; Survival Analysis; Treatment Outcome; Vitrectomy

2001
[Non-leukemic disease of the central nervous system in children with acute lymphoblastic leukemia. II. Methotrexate-induced encephalopathy (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1978, Volume: 126, Issue:12

    Topics: Autopsy; Brain Diseases; Calcinosis; Cerebellar Diseases; Child; Consciousness; Dysarthria; Electroencephalography; Humans; Leukemia, Lymphoid; Methotrexate; Paralysis; Seizures

1978

Trials

2 trial(s) available for methotrexate and Seizures

ArticleYear
Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Cytarabine; Dexamethasone; Female; Humans; Hydrocortisone; Incidence; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures; Vincristine

2017
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
    Blood, 2007, Apr-15, Volume: 109, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Vincristine

2007

Other Studies

64 other study(ies) available for methotrexate and Seizures

ArticleYear
Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes.
    Haematologica, 2022, 10-01, Volume: 107, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Central Nervous System; Genome-Wide Association Study; Genotype; Humans; Methotrexate; Phenotype; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures

2022
Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:2

    Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Seizures

2023
[Analysis of clinical and imaging features of 6 cases of linear scleroderma en coup de sabre with central nervous system involvement in children].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2022, Nov-02, Volume: 60, Issue:11

    Topics: Alopecia; Anticonvulsants; Brain; Calcinosis; Child; Drug Resistant Epilepsy; Encephalomalacia; Female; Headache; Humans; Methotrexate; Prednisone; Retrospective Studies; Scleroderma, Localized; Seizures

2022
Neuropsychiatric manifestations in adult-onset Still's disease.
    BMJ case reports, 2020, Sep-08, Volume: 13, Issue:9

    Topics: Aggression; Anticonvulsants; Arthralgia; Diagnosis, Differential; Electroencephalography; Female; Fever; Glucocorticoids; Humans; Levetiracetam; Lorazepam; Mania; Methotrexate; Middle Aged; Paranoid Behavior; Seizures; Still's Disease, Adult-Onset; Treatment Outcome

2020
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
    Leukemia research, 2018, Volume: 65

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Polyneuropathies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Sinus Thrombosis, Intracranial; Treatment Outcome; Vincristine; Vocal Cord Paralysis

2018
Fatal neurological side-effects with necrosis of spinal cord following nelarabine treatment in a child with relapsed T-cell acute lymphoblastic leukemia.
    American journal of hematology, 2013, Volume: 88, Issue:12

    Topics: Antimetabolites, Antineoplastic; Arabinonucleosides; Cerebellum; Child; Cyclophosphamide; Cytarabine; Etoposide; Fatal Outcome; Guillain-Barre Syndrome; Humans; Magnetic Resonance Imaging; Male; Medulla Oblongata; Methotrexate; Necrosis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Seizures; Spinal Cord

2013
[Unusual antenatal gestational choriocarcinoma].
    Gynecologie, obstetrique & fertilite, 2014, Volume: 42, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Chorionic Gonadotropin; Cisplatin; Dactinomycin; Etoposide; Female; Gestational Age; Humans; Male; Methotrexate; Pregnancy; Pregnancy Outcome; Prognosis; Seizures; Tomography, X-Ray Computed; Uterine Neoplasms

2014
Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebrovascular Disorders; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Female; Headache; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Retrospective Studies; Risk Factors; Seizures; Spinal Puncture; Time Factors; Venous Thromboembolism; Venous Thrombosis; Young Adult

2015
[CENTRAL NERVOUS SYSTEM INVOLVEMENT IN GRANULOMATOSIS WITH POLYANGIITIS (GPA)].
    Harefuah, 2015, Volume: 154, Issue:5

    Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Antimetabolites, Antineoplastic; Antineoplastic Protocols; Brain Neoplasms; Craniotomy; Disease Progression; Fatal Outcome; Female; Frozen Sections; Granulomatosis with Polyangiitis; Humans; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Methotrexate; Radiotherapy; Seizures; Temporal Lobe; Tomography, X-Ray Computed; Unconsciousness

2015
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients.
    Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Humans; Leukemia; Methionine; Methotrexate; Myelin Sheath; Neurotoxicity Syndromes; Nitrous Oxide; Nutritional Status; Seizures; Vitamin B 12 Deficiency

2016
Mesial temporal sclerosis after posterior reversible encephalopathy syndrome.
    Pediatric neurology, 2009, Volume: 41, Issue:3

    Topics: Antineoplastic Agents; Brain Diseases; Burkitt Lymphoma; Child; Diffusion Magnetic Resonance Imaging; Epilepsy, Temporal Lobe; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Risk Factors; Sclerosis; Seizures; Syndrome; Temporal Lobe

2009
Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:2

    Topics: Anti-Infective Agents; Antimetabolites, Antineoplastic; Child, Preschool; Humans; Hypoglycemia; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Trimethoprim, Sulfamethoxazole Drug Combination

2011
Intraventricular rituximab and systemic chemotherapy for treatment of central nervous system post-transplant lymphoproliferative disorder after kidney transplantation.
    Pediatric transplantation, 2012, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Antibodies, Monoclonal, Murine-Derived; B-Lymphocytes; Central Nervous System Diseases; Dexamethasone; Drug Therapy, Combination; Epstein-Barr Virus Infections; Fatal Outcome; Herpesvirus 4, Human; Humans; Immunologic Factors; Infusions, Intraventricular; Kidney Transplantation; Lymphoproliferative Disorders; Magnetic Resonance Imaging; Male; Methotrexate; Postoperative Complications; Prognosis; Rituximab; Seizures; Treatment Outcome

2012
Drug-drug interaction between methotrexate and levetiracetam in a child treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2013, Volume: 60, Issue:2

    Topics: Adolescent; Anticonvulsants; Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Humans; Levetiracetam; Male; Methotrexate; Piracetam; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures

2013
[Cutaneous revelation of Rosai-Dorfman disease: 7 cases].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:2

    Topics: Adult; Aged; Antigens, CD1; Biomarkers; Brain; Delayed Diagnosis; Diagnostic Errors; Emperipolesis; Facial Dermatoses; Female; Glucocorticoids; Histiocytes; Histiocytosis, Sinus; Humans; Male; Methotrexate; Middle Aged; Nasal Obstruction; Remission, Spontaneous; Retrospective Studies; S100 Proteins; Seizures; Skin

2013
TREATMENT OF "LEUKEMIC ENCEPHALOPATHY" WITH INTRATHECAL AMETHOPTERIN.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Brain Diseases; Carbohydrates; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cranial Nerves; Folic Acid Antagonists; Headache; Hematocrit; Humans; Injections; Injections, Spinal; Leukemia; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Seizures; Toxicology

1964
BRAIN DAMAGE AFTER INTRACAROTID INFUSION OF METHOTREXATE.
    Archives of neurology, 1964, Volume: 11

    Topics: Brain; Brain Diseases; Brain Neoplasms; Carotid Arteries; Cerebrovascular Disorders; Drug Therapy; Facial Paralysis; Injections, Intra-Arterial; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Metastasis; Paresis; Pathology; Seizures; Toxicology

1964
Patients presenting with CNS lesions. Case 1. Primary low-grade mucosa-associated B-cell lymphoma of the dura.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Nov-01, Volume: 21, Issue:21

    Topics: Adult; Antimetabolites, Antineoplastic; Combined Modality Therapy; Diagnosis, Differential; Dura Mater; Female; Headache; Humans; Immunohistochemistry; Lymphoma, B-Cell, Marginal Zone; Magnetic Resonance Imaging; Meningeal Neoplasms; Methotrexate; Seizures; Tomography, X-Ray Computed

2003
[Neuropsychiatric manifestations in systemic lupus erythematosus and the treatment of intrathecal methotrexate plus dexamethasone].
    Zhonghua yi xue za zhi, 2006, Mar-21, Volume: 86, Issue:11

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Child; Dexamethasone; Drug Therapy, Combination; Female; Headache; Hospital Mortality; Humans; Injections, Spinal; Lupus Vasculitis, Central Nervous System; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Seizures; Survival Rate

2006
A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze.
    Brain pathology (Zurich, Switzerland), 2006, Volume: 16, Issue:2

    Topics: Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Brain Diseases; Brain Edema; Brain Neoplasms; Carbamazepine; Humans; Immunoglobulin Light Chains; Lymphoma, B-Cell; Male; Methotrexate; Ocular Motility Disorders; Paraproteinemias; Seizures; Treatment Outcome; Unconsciousness

2006
Methotrexate induces seizure and decreases glutamate uptake in brain slices: prevention by ionotropic glutamate receptors antagonists and adenosine.
    Life sciences, 2006, Dec-03, Volume: 80, Issue:1

    Topics: Adenosine; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Methotrexate; Mice; Neuroprotective Agents; Quinoxalines; Seizures

2006
En coup de sabre morphea and Parry-Romberg syndrome: a retrospective review of 54 patients.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Dermatologic Agents; Disease Progression; Facial Hemiatrophy; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Scleroderma, Localized; Seizures

2007
Seizure-promoting effect of blood-brain barrier disruption.
    Epilepsia, 2007, Volume: 48, Issue:4

    Topics: Adult; Animals; Antineoplastic Agents; Biomarkers; Blood-Brain Barrier; Brain; Brain Neoplasms; Cerebrovascular Disorders; Disease Models, Animal; Electroencephalography; Female; Functional Laterality; Humans; Infusions, Intra-Arterial; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Osmotic Pressure; S100 Proteins; Seizures; Swine; Tomography, X-Ray Computed; Treatment Outcome

2007
[Behçet's disease in treatment with cyclosporine and seizures: diagnostic dilemma].
    Revista clinica espanola, 2007, Volume: 207, Issue:8

    Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Behcet Syndrome; Cyclosporins; Electroretinography; Emergencies; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Intraocular Pressure; Methotrexate; Seizures; Time Factors; Valproic Acid

2007
Re: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
    Blood, 2007, Sep-01, Volume: 110, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures

2007
Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis.
    British journal of haematology, 2008, Volume: 140, Issue:3

    Topics: Antineoplastic Agents; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Clinical Protocols; Cohort Studies; Dexamethasone; Etoposide; Female; Humans; Infant; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Methotrexate; Proportional Hazards Models; Seizures; Stem Cell Transplantation; Survival Rate; Tomography, X-Ray Computed

2008
Perioperative complications of blood brain barrier disruption under general anesthesia: a retrospective review.
    Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Carotid Arteries; Central Nervous System Neoplasms; Electrocardiography; Female; Gadolinium; Humans; Hypertonic Solutions; Infusions, Intra-Arterial; Intraoperative Complications; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Postoperative Complications; Postoperative Nausea and Vomiting; Retrospective Studies; Seizures; Tachycardia; Tomography, X-Ray Computed; Vertebral Artery

2008
Therapy of acute lymphoblastic leukaemia in childhood: effects on the nervous system.
    Neuropadiatrie, 1980, Volume: 11, Issue:1

    Topics: Asparaginase; Blood-Brain Barrier; Brain Diseases; Cyclophosphamide; Cytosine; Drug-Related Side Effects and Adverse Reactions; Humans; Leukemia, Lymphoid; Methotrexate; Peripheral Nervous System Diseases; Seizures; Vincristine

1980
Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning.
    AJR. American journal of roentgenology, 1983, Volume: 141, Issue:4

    Topics: Adult; Blood-Brain Barrier; Brain; Brain Neoplasms; Carotid Artery, Internal; Child; Drug Therapy, Combination; Female; Humans; Iothalamate Meglumine; Male; Mannitol; Methotrexate; Middle Aged; Osmosis; Pentetic Acid; Radionuclide Imaging; Seizures; Technetium; Technetium Tc 99m Pentetate; Tomography, X-Ray Computed

1983
[Convulsions and intrathecal methotrexate].
    Medicina clinica, 1983, May-07, Volume: 80, Issue:16

    Topics: Child; Female; Humans; Injections, Spinal; Methotrexate; Seizures

1983
Decreased phenytoin level during antineoplastic therapy: a case report.
    Epilepsia, 1983, Volume: 24, Issue:1

    Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Drug Interactions; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Phenobarbital; Phenytoin; Seizures; Vinblastine

1983
Prognosis and treatment of seizures in children with acute lymphoblastic leukemia.
    Epilepsia, 1995, Volume: 36, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Epilepsy; Female; Humans; Incidence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Retrospective Studies; Seizures; Vincristine

1995
Seizure and methotrexate therapy in rheumatoid arthritis.
    The Journal of rheumatology, 1993, Volume: 20, Issue:9

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Seizures

1993
Cerebral arterial disturbances in a transient encephalopathy induced by methotrexate.
    Medical oncology and tumor pharmacotherapy, 1993, Volume: 10, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Humans; Leucovorin; Methotrexate; Osteosarcoma; Seizures; Syndrome

1993
Reversible MRI lesions.
    Neurology, 1996, Volume: 46, Issue:4

    Topics: Cyclosporine; Humans; Magnetic Resonance Imaging; Methotrexate; Seizures

1996
Piperacillin-induced seizures.
    Clinical pediatrics, 1997, Volume: 36, Issue:8

    Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child; Humans; Male; Mercaptopurine; Methotrexate; Piperacillin; Pseudomonas Infections; Seizures; Sepsis; Staphylococcal Infections

1997
Pure methotrexate encephalopathy presenting with seizures: CT and MRI features.
    Pediatric radiology, 1998, Volume: 28, Issue:2

    Topics: Antineoplastic Agents; Brain; Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Tomography, X-Ray Computed

1998
Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). II. The influence on the seizure activity and the learning and memory processes in mice.
    Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1998, Volume: 53

    Topics: Animals; Brain; Doxorubicin; Drug Interactions; Female; gamma-Aminobutyric Acid; Hexobarbital; Learning; Male; Memory; Methotrexate; Mice; Pentylenetetrazole; Seizures; Sleep

1998
Seizures following intrathecal cytosine arabinoside in young children with acute lymphoblastic leukemia.
    Cancer, 1978, Volume: 42, Issue:1

    Topics: Brain Neoplasms; Child, Preschool; Cytarabine; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radiography; Seizures; Seizures, Febrile; Time Factors

1978
[ZNS complications in children with acute lymphatic leukemia. Computer tomographic studies].
    Fortschritte der Medizin, 1979, Sep-13, Volume: 97, Issue:34

    Topics: Adolescent; Brain Abscess; Calcinosis; Cerebral Hemorrhage; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Lymphoma; Methotrexate; Paralysis; Remission, Spontaneous; Seizures; Subacute Sclerosing Panencephalitis; Tomography, X-Ray Computed

1979
Effects of chemotherapy on the central nervous system. A study of parenteral methotrexate in long-term survivors of leukemia and lymphoma in childhood.
    Cancer, 1976, Volume: 37, Issue:2 Suppl

    Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Electroencephalography; Humans; Infant; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Psychological Tests; Seizures

1976
Neuropharmacological effects of methotrexate perfused through the cerebrospinal fluid system of the rhesus monkey.
    Cancer research, 1976, Volume: 36, Issue:10

    Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Central Nervous System; Cerebrospinal Fluid; Discrimination, Psychological; Eating; Female; Haplorhini; Inulin; Macaca; Male; Methotrexate; Motor Activity; Seizures

1976
Chronic neurologic disturbance in childhood leukemia.
    Cancer, 1976, Volume: 37, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Learning Disabilities; Leukemia; Leukemia, Lymphoid; Methotrexate; Movement Disorders; Nervous System Diseases; Prospective Studies; Radiotherapy; Seizures; Time Factors

1976
Methotrexate may lower seizure threshold in patients with epilepsy.
    The Journal of rheumatology, 1992, Volume: 19, Issue:6

    Topics: Adult; Epilepsy; Female; Humans; Methotrexate; Middle Aged; Seizures

1992
High-dose methotrexate does not affect the pharmacodynamics of phenobarbital hypnotic action but decreases the central nervous system (CNS) sensitivity to pentylenetetrazol-induced maximal seizures in rats.
    Pharmaceutical research, 1992, Volume: 9, Issue:10

    Topics: Animals; Brain Chemistry; Central Nervous System; Chromatography, High Pressure Liquid; Glucose; Hypnotics and Sedatives; Infusions, Intravenous; Male; Methotrexate; Pentylenetetrazole; Phenobarbital; Postural Balance; Rats; Reflex; Seizures

1992
Neurologic complications in children with soft tissue and osseous sarcoma.
    Cancer, 1989, Dec-15, Volume: 64, Issue:12

    Topics: Adolescent; Bone Neoplasms; Brain Diseases; Brain Neoplasms; Child; Humans; Methotrexate; Nervous System Diseases; Peripheral Nervous System Diseases; Retrospective Studies; Sarcoma; Seizures; Soft Tissue Neoplasms; Spinal Cord Compression

1989
Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Seizures

1989
Convulsions and intracranial calcifications in a leukemic infant receiving only intrathecal methotrexate as central nervous system prophylaxis.
    Pediatric hematology and oncology, 1987, Volume: 4, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Diseases; Calcinosis; Cyclophosphamide; Doxorubicin; Humans; Infant; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Seizures; Vincristine

1987
Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia.
    Medical and pediatric oncology, 1986, Volume: 14, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Digestive System; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis; Risk; Seizures

1986
Transient cerebral dysfunction secondary to high-dose methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Brain Diseases; Electroencephalography; Female; Glioma; Hodgkin Disease; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Paresis; Seizures; Syndrome

1986
[Transient cerebral dysfunction induced by VCR, HD-MTX in a child with acute lymphocytic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1986, Volume: 27, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Drug Administration Schedule; Electroencephalography; Humans; Leukemia, Lymphoid; Male; Methotrexate; Seizures; Vincristine

1986
Toxicity of methotrexate in rheumatoid arthritis.
    The Journal of rheumatology, 1987, Volume: 14, Issue:1

    Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; HLA Antigens; Humans; Leukopenia; Male; Meningitis, Listeria; Methotrexate; Middle Aged; Pulmonary Fibrosis; Retrospective Studies; Seizures

1987
A model of methotrexate encephalopathy: neurotransmitter and pathologic abnormalities.
    Journal of child neurology, 1986, Volume: 1, Issue:4

    Topics: Animals; Brain; Brain Diseases; Chromatography, High Pressure Liquid; Dopamine; Male; Methotrexate; Rats; Rats, Inbred Strains; Seizures; Serotonin

1986
Remission induction of meningeal leukemia with high-dose intravenous methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Methotrexate; Neutropenia; Seizures; Stomatitis

1985
Response of astrocytoma to high-dose methotrexate with citrovorum factor rescue.
    Cancer, 1985, Jun-15, Volume: 55, Issue:12

    Topics: Adolescent; Adult; Angiography; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neurologic Examination; Seizures; Tomography, X-Ray Computed

1985
Neurologic complications of bone marrow transplantation.
    Neurology, 1985, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Diseases, Metabolic; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Child; Child, Preschool; Female; Graft vs Host Disease; Humans; Infections; Leukemia; Male; Methotrexate; Middle Aged; Necrosis; Neoplasms; Postoperative Complications; Seizures; Spinal Cord Diseases

1985
The epileptogenic effects of folate derivatives in the rat.
    Journal of the neurological sciences, 1973, Volume: 20, Issue:2

    Topics: Aminobenzoates; Animals; Calcium; Central Nervous System Stimulants; Cerebral Cortex; Electroencephalography; Folic Acid; Glutamates; Leucovorin; Methotrexate; Pterins; Rats; Seizures; Sodium; Somatosensory Cortex; Tetrahydrofolates

1973
[Mechanism of convulsive action of intraventricular injections of folic acid (pteroyl-glutamate) and calcium folinate (N5 formyl tetrahydrofolinate) in the rabbit. 1-Action of 4-amino 10-methylfolic acid (Methotrexate)].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1974, Volume: 15, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Cerebral Ventricles; Folic Acid; Folic Acid Antagonists; Injections; Methotrexate; Rabbits; Seizures

1974
[Neurotoxicity of some antineoplastic agents].
    Bollettino della Societa italiana di biologia sperimentale, 1974, Sep-15, Volume: 50, Issue:17

    Topics: Antineoplastic Agents; Child; Child, Preschool; Doxorubicin; Facial Paralysis; Humans; Infant; Leukemia; Lymphoma; Methotrexate; Motor Neurons; Myasthenia Gravis; Neoplasms; Nervous System; Nervous System Diseases; Paresthesia; Seizures; Vinblastine; Vincristine

1974
[Serious neurological syndrome observed after first intraspinal administration of methotrexate in a child with acute lymphatic leukemia].
    Minerva pediatrica, 1973, Mar-31, Volume: 25, Issue:11

    Topics: Apnea; Brain; Child, Preschool; Drug Hypersensitivity; Electroencephalography; Humans; Injections; Leukemia, Lymphoid; Male; Methotrexate; Neurologic Manifestations; Seizures; Spine

1973
Letter: Pyrimethamine poisoning.
    British medical journal, 1973, Dec-29, Volume: 4, Issue:5895

    Topics: Drug Interactions; Humans; Leukemia; Methotrexate; Pyrimethamine; Seizures

1973
The neurology of metastatic chorion carcinoma of the uterus.
    Journal of the neurological sciences, 1972, Volume: 16, Issue:3

    Topics: Adult; Blood Transfusion; Brain; Brain Neoplasms; Cerebral Angiography; Cerebrovascular Disorders; Choriocarcinoma; Dactinomycin; Encephalitis; Female; Headache; Hemiplegia; Humans; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Neurologic Manifestations; Pregnancy; Seizures; Uterine Neoplasms

1972
Folic acid and convulsions in the rat.
    Biochemical pharmacology, 1971, Volume: 20, Issue:7

    Topics: Animals; Drug Interactions; Female; Folic Acid; Formates; Male; Methotrexate; Pentylenetetrazole; Rats; Seizures; Time Factors

1971
The effect of anti-metabolites on leptazol induced fits in rats.
    Clinical science, 1971, Volume: 40, Issue:6

    Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; Folic Acid Antagonists; Methotrexate; Pentylenetetrazole; Pyrimethamine; Rats; Seizures

1971