methotrexate has been researched along with Sarcoma 180 in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (79.31) | 18.7374 |
| 1990's | 8 (13.79) | 18.2507 |
| 2000's | 3 (5.17) | 29.6817 |
| 2010's | 1 (1.72) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaumont, Y; Kisliuk, RL; McCaleb, GS; Montgomery, JA; Piper, JR; Sirotnak, FM | 1 |
| Duan, D; Gao, L; Liu, X; Luo, L; Xia, L; Xu, J; Zhang, R | 1 |
| Jiang, YY; Kong, SY; Pei, YY; Tang, GT | 1 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD; MUSSER, EA | 1 |
| Su, J; Zhang, SH; Zhen, YS | 1 |
| Balthasar, JP; Lobo, ED | 1 |
| Hakala, MT; Suolinna, EM | 1 |
| Hakala, MT; Raunio, RP | 1 |
| Chello, PL; Poser, RG; Sirotnak, FM | 1 |
| Kellems, RE; Leys, EJ | 1 |
| Poser, RG; Sirotnak, FM | 1 |
| Browman, GP | 1 |
| Bover, L; Cabral, S; Leis, S; Mordoh, J; Nembrot, M | 1 |
| Li, JS; Lin, JY; Tung, TC | 1 |
| Chello, PL; DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Cheng, YC; Domin, BA; Hakala, MT | 1 |
| Hancock, CH; Moccio, DM; Sirotnak, FM; Young, CW | 1 |
| Brown, PC; Kaufman, RJ; Schimke, RT | 1 |
| Fukunaga, M; Iba, T; Kidokoro, A; Uchida, J; Yagi, Y | 1 |
| Chandraprakash, KS; Pillai, GK; Udupa, N; Umadevi, P | 1 |
| Awazu, S; Horie, T; Nagai, Y | 1 |
| Johnson, CA; Maddry, JA; McGuire, JJ; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Singh, UV; Udupa, N | 1 |
| Chiao, JH; Roy, K; Sirotnak, FM; Tolner, B | 1 |
| Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Alt, FW; Kellems, RE; Schimke, RT | 2 |
| Donsbach, RC; Dorick, DM; Moccio, DM; Sirotnak, FM | 2 |
| Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Bertino, JR; Gupta, VS; Lindquist, CA; Sawicki, WL | 1 |
| Donsback, RC; Sirotnak, FM | 1 |
| Balcarová, A; Motycka, K | 1 |
| Chodera, A; Hladoń, B | 1 |
| Barrueco, JR; O'Leary, DF; Sirotnak, FM | 2 |
| Goutas, LJ; Piper, JR; Priest, DG; Samuels, LL; Sirotnak, FM | 1 |
| Cao, SS | 1 |
| Cao, SS; Zhen, YS | 1 |
| Montgomery, JA; Otter, GM; Piper, JR; Schmid, FA; Sirotnak, FM | 1 |
| Akiyama, S; Komiyama, S; Kuwano, M; Nakagawa, M; Ogata, J; Shiraishi, N; Ueda, H; Yamaguchi, T | 1 |
| Herrmann, R; Kunz, W; Osswald, H; Port, R; Ritter, M | 1 |
| Bertino, JR; Skeel, RT | 1 |
| Divekar, AY; Fleysher, MH; Hakala, MT; Kenny, LN; Slocum, HK | 1 |
| Divekar, AY; Hakala, MT; Slocum, HK | 1 |
| Hakala, MT | 3 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 2 |
| Hakala, MT; Ho, YK; Zakrzewski, SF | 1 |
| Averbukh, LA; Bazhanov, VS; Grinshteĭn, AM; Lepeshkina, GN; Shorin, VA | 1 |
| Hauschka, TS; Holdridge, BA | 1 |
| Calcutt, G | 1 |
| Brockman, RW; Dixon, GJ; Dulmadge, EA; Shaddix, SC | 1 |
| Aunio, R; Hakala, MT | 1 |
| Solomon, JB | 1 |
1 trial(s) available for methotrexate and Sarcoma 180
| Article | Year |
|---|---|
Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA; Drug Synergism; Fluorouracil; Humans; Immunosuppression Therapy; Mammary Neoplasms, Experimental; Methotrexate; Mice; Neoplasms; Phosphoribosyl Pyrophosphate; Rats; RNA; Sarcoma 180; Thymidylate Synthase | 1984 |
57 other study(ies) available for methotrexate and Sarcoma 180
| Article | Year |
|---|---|
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma 180 | 1982 |
Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Implants; Drug Liberation; Female; Lactic Acid; Male; Methotrexate; Mice; Microscopy, Electron, Scanning; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Sarcoma 180 | 2017 |
[PEGylated polyamidoamine dendrimer/methotrexate complex: pharmacokinetics and anti-tumor activity in normal and tumor-bearing rodents].
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Cell Line, Tumor; Dendrimers; Drug Carriers; Female; Male; Methotrexate; Mice; Neoplasm Transplantation; Nylons; Polyethylene Glycols; Random Allocation; Rats; Rats, Sprague-Dawley; Sarcoma 180; Tumor Burden | 2009 |
THE EFFECT OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE HYDROCHLORIDE ON MURINE NEOPLASMS.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Blood Cells; Carcinoma, Ehrlich Tumor; Cortisone; Cytarabine; Cytosine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Biological Transport; Caffeic Acids; Drug Synergism; Drugs, Chinese Herbal; Female; Fluorouracil; Humans; KB Cells; Lactates; Male; Methotrexate; Mice; Mitomycin; Neoplasm Transplantation; Plants, Medicinal; Salvia miltiorrhiza; Sarcoma 180; Tumor Cells, Cultured | 2004 |
Application of anti-methotrexate Fab fragments for the optimization of intraperitoneal methotrexate therapy in a murine model of peritoneal cancer.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Area Under Curve; Body Weight; Combined Modality Therapy; Disease Models, Animal; Half-Life; Immunoglobulin Fab Fragments; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Mice; Peritoneal Neoplasms; Sarcoma 180; Survival Rate | 2005 |
Specific protection of folate reductase against chemical and proteolytic inactivation.
Topics: Animals; Carboxypeptidases; Chloromercuribenzoates; Chymotrypsin; Ethylenediamines; Glutamates; Iodoacetates; Leucyl Aminopeptidase; Methotrexate; Peptide Hydrolases; Phenanthrolines; Purines; Pyrimidines; Sarcoma 180; Temperature; Tetrahydrofolate Dehydrogenase; Trypsin | 1966 |
Comparison of folate reductases of sarcoma 180 cells, sensitive and resistant to amethopterin.
Topics: Animals; Chromatography, Gel; Culture Techniques; Dextrans; Electrophoresis; Methotrexate; Molecular Weight; Oxidoreductases; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1967 |
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.
Topics: Animals; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; Intestine, Small; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Peptide Biosynthesis; Polyglutamic Acid; Sarcoma 180; Time Factors | 1981 |
Control of dihydrofolate reductase messenger ribonucleic acid production.
Topics: Animals; Cell Division; Cell Nucleus; Cells, Cultured; Cytoplasm; DNA, Recombinant; Drug Resistance; Methotrexate; Mice; Nucleic Acid Hybridization; Poly A; RNA; RNA, Messenger; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1981 |
Studies on the in vivo synthesis of methotrexate polyglutamates and their efflux properties in normal, proliferative, and neoplastic mouse tissues.
Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Intestine, Small; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Mice, Inbred Strains; Peptides; Polyglutamic Acid; Sarcoma 180 | 1983 |
Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.
Topics: Animals; Biological Transport; Deoxycytidine; Deoxyuridine; Dipyridamole; DNA Replication; Drug Antagonism; Kinetics; Methotrexate; Mice; Sarcoma 180; Thymidine; Thymine Nucleotides | 1984 |
Lectin derivatives of methotrexate and chlorambucil as chemotherapeutic agents.
Topics: Abrin; Animals; Chlorambucil; Concanavalin A; DNA, Neoplasm; Lectins; Male; Methotrexate; Mice; Ricin; Sarcoma 180 | 1981 |
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Membranes; Methotrexate; Mice; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1982 |
Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.
Topics: Animals; Cell Line; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Humans; Isoelectric Focusing; Kinetics; Methotrexate; Mice; Molecular Weight; Neoplasms, Experimental; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1982 |
Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport.
Topics: Animals; Biological Transport, Active; Bone Marrow; Female; Kidney; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Mice, Inbred Strains; Probenecid; Sarcoma 180 | 1981 |
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.
Topics: Animals; Cell Line; Chromosome Aberrations; Clone Cells; DNA; Drug Resistance; Extrachromosomal Inheritance; Flow Cytometry; Gene Amplification; Methotrexate; Mice; Nucleic Acid Hybridization; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1981 |
[The mechanism of biochemical modulation in methotrexate/5-fluorouracil sequential chemotherapy].
Topics: Animals; Drug Administration Schedule; Drug Synergism; Fluorouracil; Methotrexate; Mice; RNA, Neoplasm; Sarcoma 180; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Effect of macrophage activation on plasma disposition of niosomal 3H-methotrexate in sarcoma-180 bearing mice.
Topics: Animals; Drug Compounding; Hexoses; Macrophage Activation; Methotrexate; Mice; Microspheres; Neoplasm Transplantation; Sarcoma 180; Surface-Active Agents | 1993 |
Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
Topics: Animals; Cell Division; Intestine, Small; Leukemia L1210; Lipids; Malabsorption Syndromes; Male; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Neoplasm Transplantation; Proteins; Sarcoma 180; Vitamin A | 1993 |
Analogues of classical antifolates bearing naphthoyl in place of benzoyl.
Topics: Adenocarcinoma; Animals; Cell Line; Cell Survival; Computer Graphics; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Experimental; Methotrexate; Mice; Models, Molecular; Peptide Synthases; Sarcoma 180; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
In vitro characterization of methotrexate loaded poly(lactic-co-glycolic) acid microspheres and antitumor efficacy in Sarcoma-180 mice bearing tumor.
Topics: Animals; Antimetabolites, Antineoplastic; Capsules; Drug Carriers; Drug Compounding; Drug Screening Assays, Antitumor; Lactic Acid; Methotrexate; Mice; Mice, Inbred BALB C; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Sarcoma 180; Surface Properties | 1997 |
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within
Topics: Amino Acid Sequence; Aminopterin; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Sarcoma 180; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 1998 |
[Sensitivity tests of malignant tumours against cytostatic agents in vitro and in vivo/studies on the mouse sarcoma 180 (author's transl)].
Topics: Animals; Antineoplastic Agents; Biological Transport; Bleomycin; Cell Membrane Permeability; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Methotrexate; Mice; Mice, Inbred Strains; Podophyllin; Sarcoma 180; Uridine | 1975 |
Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.
Topics: Animals; Cell Line; Drug Resistance; gamma-Globulins; Kinetics; Methotrexate; Nucleic Acid Denaturation; Protein Biosynthesis; RNA, Messenger; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1976 |
High-dose methotrexate therapy with citrovorum factor: a pharmacologic perspective in murine tumor models.
Topics: Animals; DNA; DNA, Neoplasm; Drug Therapy, Combination; Intestine, Small; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma 180; Time Factors | 1977 |
Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.
Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Sarcoma 180; Time Factors | 1978 |
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180 | 1978 |
Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.
Topics: Animals; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Methotrexate; Mice; Sarcoma 180; Time Factors | 1977 |
Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.
Topics: Animals; Cell Line; Drug Resistance; Humans; Infant, Newborn; Leucine; Methotrexate; Neoplasm Proteins; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1976 |
Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.
Topics: Animals; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Intestine, Small; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1976 |
Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.
Topics: Aminopterin; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Chick Embryo; DNA, Neoplasm; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Quinazolines; Sarcoma 180; Tetrahydrofolate Dehydrogenase; Time Factors | 1975 |
Methotrexate and folic acid effect in normal and sarcoma 180 bearing mice.
Topics: Administration, Oral; Animals; Folic Acid; Methotrexate; Mice; Sarcoma 180 | 1975 |
Sesquiterpene lactones XVII. Cytostatic and pharmacological activity.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dactinomycin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Sarcoma 180; Sesquiterpenes; Transplantation, Homologous | 1975 |
Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds.
Topics: Animals; beta-N-Acetylhexosaminidases; Biological Transport; Cysteine; gamma-Glutamyl Hydrolase; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Mercaptoethanol; Methotrexate; Mice; Models, Biological; Oxidation-Reduction; Polyglutamic Acid; Sarcoma 180; Sulfhydryl Compounds | 1992 |
Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Glutamates; Glutamine; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polyglutamic Acid; Sarcoma 180; Temperature | 1992 |
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse.
Topics: Animals; Carboxypeptidases; gamma-Glutamyl Hydrolase; Intestine, Small; Kinetics; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Sarcoma 180; Substrate Specificity; Tissue Distribution | 1986 |
[Potentiated antitumor effect of methotrexate by dipyridamole].
Topics: Amphotericin B; Animals; Antineoplastic Agents; Biological Transport; Dipyridamole; Drug Synergism; Female; Leukemia L1210; Male; Methotrexate; Mice; Nucleosides; Sarcoma 180; Tumor Cells, Cultured | 1989 |
Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B.
Topics: Amphotericin B; Animals; Antimetabolites, Antineoplastic; Dipyridamole; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Lung Neoplasms; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Sarcoma 180; Uterine Cervical Neoplasms | 1989 |
Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models.
Topics: Adenocarcinoma; Alkylation; Aminopterin; Animals; Drug Compounding; Epithelium; Intestine, Small; Kinetics; Mammary Neoplasms, Experimental; Methotrexate; Mice; Sarcoma 180; Structure-Activity Relationship | 1988 |
Potentiation by vitamin A of the action of anticancer agents against murine tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diterpenes; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Leukemia P388; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Retinyl Esters; Sarcoma 180; Vitamin A | 1985 |
The effect of methotrexate pretreatment on 5-fluorouracil kinetics in sarcoma 180 in vivo.
Topics: Animals; Drug Administration Schedule; Female; Fluorouracil; Kinetics; Methotrexate; Mice; RNA, Neoplasm; Sarcoma 180; Thymidylate Synthase | 1985 |
Combination chemotherapy of sarcoma 180 with methotrexate and bleomycin.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Body Weight; Female; Methotrexate; Mice; Mice, Inbred Strains; Sarcoma 180; Time Factors | 1973 |
Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.
Topics: Adenosine; Alkenes; Aminohydrolases; Animals; Carbon Isotopes; Cell Division; Cells, Cultured; Chromatography, Paper; Cross Reactions; Deamination; Drug Resistance; Floxuridine; Furans; Inosine; Methotrexate; Mice; Pentosyltransferases; Phosphotransferases; Purines; Ribonucleosides; Sarcoma 180; Time Factors | 1972 |
N6-(delta2-isopentenyl)adenosine 5'-monophosphate: formation and effect on purine metabolism in cellular and enzymatic systems.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Alkenes; Animals; Carbon Radioisotopes; Cells; Cells, Cultured; Chromatography, Paper; Glycine; Hypoxanthines; Inosine Nucleotides; Ketone Oxidoreductases; Ligases; Lyases; Methotrexate; Pentosyltransferases; Phosphotransferases; Purines; Sarcoma 180; Time Factors | 1974 |
The essential SH-groups in folate reductase.
Topics: Animals; Benzoates; Binding Sites; Chemical Phenomena; Chemistry; Culture Techniques; Folic Acid; Folic Acid Antagonists; Methotrexate; NADP; Sarcoma 180; Sulfhydryl Compounds; Temperature; Tetrahydrofolate Dehydrogenase; Urea | 1968 |
Enhancement of antitumor effect of cyclophosphamide by centrophenoxine.
Topics: Acetates; Animals; Antineoplastic Agents; Busulfan; Central Nervous System Stimulants; Cyclophosphamide; Drug Synergism; Fluorouracil; Meclofenoxate; Mercaptopurine; Methotrexate; Mice; Mitomycins; Sarcoma 180; Vinblastine; Vincristine | 1971 |
5-(1-Adamantyl) pyrimidines as inhibitors of folate metabolism.
Topics: Animals; Bridged-Ring Compounds; Cells, Cultured; Cycloparaffins; Depression, Chemical; Escherichia coli; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Methotrexate; Pyrimidines; Sarcoma 180; Structure-Activity Relationship | 1972 |
[Antineoplastic activity of antibiotic 1719 from the group of diazo compounds].
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Azo Compounds; Carcinoma, Ehrlich Tumor; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Leukemia L1210; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sarcoma 180; Sarcoma 37; Stomach Neoplasms; Time Factors; Vaginal Neoplasms | 1972 |
Selective cell survival and changes of marker properties during cryopreservation for up to 16 years.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; Cell Survival; Chromosomes; Clone Cells; Culture Techniques; Freezing; Histocompatibility Antigens; Humans; Lymphoma; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Polyploidy; Sarcoma 180; Species Specificity; Time Factors; Tissue Preservation; Transplantation, Homologous | 1974 |
Enhanced growth of transplanted tumours after treatment with cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Ethers, Cyclic; Lymphoma; Mannomustine; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180; Stimulation, Chemical; Thiotepa; Triethylenemelamine | 1968 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cyclophosphamide; Cytarabine; Cytidine; Dose-Response Relationship, Drug; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Sarcoma 180 | 1972 |
On the nature of permeability of sarcoma-180 cells to amethopterin in vitro.
Topics: Animals; Biological Transport, Active; Calcium; Cell Membrane Permeability; Dinitrophenols; Hydrogen-Ion Concentration; In Vitro Techniques; Leucovorin; Methotrexate; Riboflavin; Sarcoma 180; Temperature; Tetrahydrofolate Dehydrogenase | 1965 |
Feedback inhibition of purine biosynthesis in adenocarcinoma 755 and sarcoma 180 cells in culture.
Topics: Adenine; Adenocarcinoma; Animals; Azaserine; Carbon Isotopes; Cell Line; Feedback; Hypoxanthines; Mercaptopurine; Methotrexate; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Purines; Sarcoma 180; Thioguanine | 1970 |
Tetrahydrofolate-dependent enzymes in sarcoma 180 cells sensitive and resistant to amethopterin.
Topics: Aminohydrolases; Animals; Culture Techniques; Folic Acid; Formates; Ligases; Methotrexate; Mice; Oxidoreductases; Sarcoma 180; Serine; Transferases; Ultracentrifugation | 1968 |
On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitro.
Topics: Aminopterin; Animals; In Vitro Techniques; Methotrexate; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1965 |
Relative growth of trophoblast and tumour cells co-implanted into isogenic mouse testes and the inhibitory action of 'methotrexate'.
Topics: Animals; Extraembryonic Membranes; Female; Male; Methotrexate; Mice; Neoplasm Transplantation; Pregnancy; Sarcoma 180; Testis; Trophoblasts | 1966 |