methotrexate has been researched along with Rheumatoid Arthritis in 5902 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 264 (4.47) | 18.7374 |
| 1990's | 878 (14.88) | 18.2507 |
| 2000's | 1407 (23.84) | 29.6817 |
| 2010's | 2414 (40.90) | 24.3611 |
| 2020's | 939 (15.91) | 2.80 |
| Authors | Studies |
|---|---|
| Colwell, WT; Crase, J; DeGraw, JI; Piper, JR; Sirotnak, FM; Smith, RL; Waud, WR | 1 |
| Colwell, WT; DeGraw, JI; Johnson, CA; Piper, JR; Sirotnak, FM; Smith, RL; Waud, WR | 1 |
| Hori, Y; Kawada, K; Kawata, K; Kokuryo, Y; Kugimiya, A; Kuwabara, K; Matsumoto, M; Nakatani, T; Ohtani, M; Suzuki, R; Tamura, Y | 1 |
| Knuckley, B; Luo, Y; Thompson, PR | 1 |
| Cai, HD; Chen, ZH; Fang, MH; Huang, HH; Su, YP; Xu, Y; Yang, J; Yu, CX; Zeng, YL | 1 |
| Bai, CG; Chen, Y; Jiang, Y; Li, HY; Li, XH; Lu, J; Zhang, Q | 1 |
| Andresen, TL; Bondebjerg, J; Clausen, MH; Hansen, AE; Hansen, CA; Peiró Cadahía, J; Previtali, V | 1 |
| Liu, L; Wang, W; Zhou, H | 1 |
| Clausen, MH; Peiró Cadahía, J; Petrovic, K; Previtali, V; Troelsen, NS | 1 |
| Chen, HJ; Liu, B; Yang, HR; Yao, QQ; Zhi, Y | 1 |
| Chen, G; Huang, G; Liu, J; Zhou, S | 1 |
| Ahirrao, P; Bakhle, D; Bhankhede, T; Bhonde, M; Bokan, S; Budhe, S; Dadke, D; Daler, J; Deshmukh, G; George, SK; Gholve, M; Gundu, J; Gupta, R; Ingawale, S; Irlapatti, NR; Jachak, S; Kalia, A; Kamalakannan, P; Kamboj, RK; Kanoje, V; Karche, V; Khedkar, NR; Kizhakinagath, PA; Kuldharan, S; Kumar, H; Kumar, S; Mallurwar, S; Mehta, M; Modi, D; Naik, K; Narasimham, L; Nemade, HN; Nemmani, KVS; Nigade, P; Padiya, KJ; Palle, VP; Pandey, D; Pareek, H; Patil, A; Patil, V; Pawar, S; Phukan, S; Shah, C; Shaikh, Z; Shankar, R; Sharma, N; Sharma, S; Shinde, V; Sindkhedkar, M; Singh, M; Sinha, N; Tamane, K; Venugopal, S; Vishwase, G; Wagh, A; Yeshodharan, R | 1 |
| Clary, DD; Fanciullo, J; Kiani, R; Reid, AT | 1 |
| Arinobu, Y; Eiraku, N; Endo, Y; Fujikawa, K; Hamada, H; Hidaka, T; Ichinose, K; Igawa, T; Iwamoto, N; Kawakami, A; Kawashiri, SY; Koga, T; Matsuoka, N; Michitsuji, T; Nakamura, H; Nawata, M; Nishihata, S; Nishino, A; Okada, A; Okamoto, M; Origuchi, T; Otsubo, H; Shimizu, T; Sumiyoshi, R; Tada, Y; Takaoka, H; Tamai, M; Tomokawa, T; Tsuji, S; Tsuji, Y; Tsuru, T; Ueki, Y; Yoshitama, T | 1 |
| Ishikawa, H; Ito, S; Kato, R | 1 |
| Badot, V; Ciregia, F; Cobraiville, G; de Seny, D; Di Romana, S; Durez, P; Fillet, M; Malaise, MG; Nys, G; Sidiras, P; Sokolova, T | 1 |
| Borlenghi, C; de la Vega, M; Guerra Bautista, G; Pacheco-Tena, C; Pedersen, RD; Santana, K; Solano, G; Szumski, AE; Vlahos, B; Xavier, RM | 1 |
| Leung, SO; Li, J; Li, M; Wu, D; Zhang, F; Zhou, J | 1 |
| Buch, MH; Burmester, GR; Bykerk, VP; Fernandez-Nebro, A; Huizinga, T; Kameda, H; Praestgaard, A; Tanaka, Y; van Hoogstraten, H | 1 |
| Homma, Y; Masui, T; Miyamoto, T; Ohmura, SI | 1 |
| Baecklund, E; Cavalli, M; Eriksson, N; Hallberg, P; Kohnke, H; Sundbaum, JK; Wadelius, C; Wadelius, M; Wallenberg, M | 1 |
| Aslam, F; Marks, LA; Pham, MM; Sullivan, MM | 1 |
| Beattie, S; Durez, P; Fleischmann, R; Kartman, CE; Mo, D; Schlichting, D; Tanaka, Y; van der Heijde, D; Xie, L | 1 |
| Coulie, P; Durez, P; Galant, C; Lauwerys, BR; Limaye, N; Méric de Bellefon, L; Sokolova, T; Tilman, G; Triaille, C | 1 |
| Goyal, M; Kedia, AK; Mohansundaram, K; Ravindran, V | 1 |
| Daraghmeh, DN; King, C; Wiese, MD | 1 |
| Hoeper, K; Nellenschulte, TF; Pardey, N; Stahmeyer, JT; Witte, T; Zeidler, J | 1 |
| Haavardsholm, EA; Lillegraven, S; Paulshus Sundlisæter, N | 1 |
| Baker, KF; Isaacs, JD; Pratt, AG | 1 |
| Hamada, T; Hata, T; Hirata, A; Katsumata, T; Nishihara, M; Ota, R; Uchiyama, K | 1 |
| Li, PH; Ni, Y; Pu, T; Yu, D; Yu, LM; Yu, Q | 1 |
| Le Merdy, M; Lukacova, V; Mullin, J | 1 |
| Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R | 1 |
| Asano, T; Fujita, Y; Kanno, T; Matsumoto, H; Matsuoka, N; Migita, K; Sato, S; Suzuki, E; Temmoku, J; Watanabe, H; Yashiro-Furuya, M | 1 |
| Belani, PJ; Kavadichanda, CG; Negi, VS | 1 |
| Aletaha, D; Kussmann, M; Obermueller, M; Spettel, K; Winkler, S | 1 |
| Ma, RR; Wu, F; Wu, TJ; Ying, ZH; Yu, JJ; Zhang, Y | 1 |
| Lee, YH; Song, GG | 10 |
| Jordan, S; Kötter, I; Ruffer, N; Schmiedel, S; Tomas, NM | 1 |
| Bensimon, A; Bergman, M; Clewell, J; Orvis, E; Tundia, N; Yang, M | 1 |
| Feathers, VL; Greenberg, J; Harrold, LL; Kane, K; Kremer, JM; Pappas, DA; Reed, G; Shadick, N; Weinblatt, ME | 1 |
| Ravaei, A; Rubini, M | 1 |
| Chhabra, M; Kumar, S; Rashid, M; Venkataraman, R; Zuber, M | 1 |
| Chen, X; Huang, Q; Huang, R; Liu, Z; Mei, L; Wang, M; Wu, X; Yang, Z; Zhang, X | 1 |
| Chen, Q; He, Y; Shen, J; Yang, G | 1 |
| Hatanaka, N; Karasuno, T; Kusakabe, S; Sata, H; Yasumi, M | 1 |
| Bakker, T; Jessurun, NT; Ten Klooster, PM; Van Lint, JA; van Puijenbroek, EP; Vonkeman, HE | 1 |
| Desai, RJ; Glynn, RJ; He, M; Kim, SC; Lee, H; Pawar, A; Solomon, DH; Weinblatt, ME | 1 |
| Lee, YH; Sung, YK | 4 |
| Inokuma, S | 1 |
| Chen, F; Jiang, X; Li, J; Zeng, J | 1 |
| Endo, Y; Furukawa, K; Ichinose, K; Igawa, T; Iwamoto, N; Kawakami, A; Kawashiri, SY; Koga, T; Origuchi, T; Shimizu, T; Sumiyoshi, R; Tamai, M; Umeda, M | 1 |
| Cervi, VF; Cruz, L; Fajardo, AR; Luchese, C; Martins, CC; Nornberg, AB; Sari, MHM; Wilhelm, EA | 1 |
| Goto, Y; Kawahata, K; Kiyokawa, T; Nagafuchi, H; Ooka, S | 1 |
| Cheng, J; Dong, H; Li, W; Wu, C; Yang, L; Zhang, X | 1 |
| Du, Y; Hu, Q; Shen, Q; Shu, G; Tang, T; Teng, C; Ying, X | 1 |
| Aldridge, J; Andersson, K; Gröndal, G; Gudbjornsson, B; Haavardsholm, EA; Hørslev-Petersen, K; Lampa, J; Lund Hetland, M; Lundell, AC; Mark, L; Nordström, D; Nurmohamed, M; Rudin, A; Schrumpf Heiberg, M; Uhlig, T; van Vollenhoven, R; Østergaard, M | 1 |
| Barrio-Alonso, C; Fuentelsaz-Romero, S; García Campos, R; García-Vicuña, R; González-Álvaro, I; Jansen, G; Miranda-Carús, ME; Muller, IB; Nuño, L; Puig-Kröger, A; Torres Torresano, M; Triguero-Martínez, A; Villalba, A | 1 |
| Dan, J; Liu, Y; Tan, J | 1 |
| Takamatsu, H; Yoroidaka, T | 1 |
| Doi, M; Egusa, Y; Filiz Nishimura, M; Fujita, A; Gion, Y; Ikeda, T; Iwaki, N; Nakamura, N; Nishikori, A; Nishimura, Y; Sakamoto, M; Sato, Y; Yoshino, T | 1 |
| Hasegawa, E; Hayami, N; Hiramatsu, R; Hoshino, J; Ikuma, D; Kawada, M; Kinowaki, K; Kono, K; Mizuno, H; Ohashi, K; Sawa, N; Sawamura, M; Sekine, A; Suwabe, T; Ubara, Y; Yamaguchi, Y; Yamanouchi, M | 1 |
| Matthijssen, XME; van der Helm-van Mil, AHM; Verstappen, M | 1 |
| Hamanaka, R; Iwazaki, M; Masuda, R | 1 |
| Anderson, JK; Feng, D; Gossec, L; Kato, K; Lesser, E; Marchesoni, A; McCaskill, R; McDearmon-Blondell, EL; Nash, P; Richette, P; Ritchlin, C; Ruderman, EM | 1 |
| Andreassen, BK; Evenrød, IM; Flåm, ST; Franke, A; Franzenburg, S; Gervin, K; Guderud, K; Lie, BA; Mjaavatten, MD; Mæhlen, MT; Norli, ES; Rayner, S; Sunde, LH | 1 |
| Frankowski, M; Gomułkiewicz, M; Korman, L; Skoczyńska, M; Starba, A; Świerkot, J | 1 |
| Cappelleri, JC; Crofford, L; Lohr, K; Nowell, WB; Rayens, MK; Salt, E; Studts, J; Wiggins, A | 1 |
| Baraliakos, X; Chen, S; Durez, P; Enejosa, JV; Friedman, A; Hall, S; Li, Y; Mysler, E; Peterfy, CG; Shaw, T; Song, IH; Strand, V | 1 |
| Abe, M; Harigai, M; Higuchi, Y; Ikari, K; Inoue, E; Nakajima, A; Ochiai, M; Saka, K; Sugano, E; Sugimoto, N; Sugitani, N; Tanaka, E; Yamaguchi, R; Yamanaka, H | 1 |
| Amano, N; Hashizume, K; Matsubara, T; Takeuchi, T; Tanaka, Y | 1 |
| Athreya, AP; Bongartz, T; Carlson, E; Crowson, CS; Davis, JM; Emery, P; Kalari, KR; Matteson, EL; Morgan, A; Myasoedova, E; Padyukov, L; Tak, PP; van Vollenhoven, RF; Walchak, RC; Wang, L; Warrington, KJ; Weinshilboum, RM | 1 |
| Amano, K; Atsumi, T; Bae, SC; Bartok, B; Combe, BG; Guo, Y; Ishiguro, N; Keystone, EC; Kivitz, AJ; Kondo, A; Matsubara, T; Matzkies, F; Nash, P; Pechonkina, A; Sugiyama, E; Sundy, JS; Takeuchi, T; Tanaka, Y; Tasset, C; Yamaoka, K; Ye, L | 1 |
| Amano, K; Atsumi, T; Bartok, B; Burmester, GR; Ching, DWT; Guo, Y; Ishiguro, N; Kondo, A; Matsubara, T; Messina, OD; Pechonkina, A; Sugiyama, E; Sundy, JS; Takeuchi, T; Tanaka, Y; Tasset, C; Westhovens, R; Yamaoka, K; Yin, Z | 1 |
| Hagino, O; Kameda, H; Kato, N; Sumi, M; Takahashi, T; Tanaka, Y; Van Hoogstraten, H; Xu, C | 1 |
| Li, C; Li, X; Su, H; Wang, H; Zou, X | 1 |
| Cao, J; Li, X; Qi, W; Xia, Y | 1 |
| Iwamoto, M; Kamata, Y; Nagashima, T; Nakamura, J; Saito, K; Sato, K; Sato, T; Yanagida, M | 1 |
| Gao, C; Li, X; Su, R; Wang, C; Xue, H; Yan, H | 1 |
| Bingham, CO; Combe, B; Hu, H; Khalid, JM; Lee, SJ; Nash, P; Walker, D; Ye, L | 1 |
| Almaghlouth, I; Bedaiwi, MK; Omair, MA | 1 |
| Machinami, R; Minemura, N; Morita, S; Ohshima, M; Sakai, S; Suzuki, A; Suzuki, T; Torikata, C; Yoshida, M | 1 |
| Doria, A; Fuzzi, E; Giollo, A | 1 |
| Krüger, K | 10 |
| Li, Y; Wang, L; Zhang, Y; Zhu, L | 1 |
| Chong, SS; Khor, CC; Koh, ET; Lee, CG; Leong, KP; Lim, AJW; Lim, LJ; Ooi, BNS; Tan, JWL; Tucker-Kellogg, L | 2 |
| Ito, Y; Kawakami, A; Kawasaki, R; Kawashiri, SY; Kawazoe, Y; Kuroda, S; Morimoto, S; Sato, S; Shimizu, T; Yamamoto, H | 1 |
| Bertelle, D; Bixio, R; Carletto, A; Pedrollo, E; Pistillo, F; Rossini, M; Viapiana, O | 1 |
| Amling, M; Beil, FT; Kötter, I; Krusche, M; Rolvien, T; Ruffer, N | 1 |
| Balkan, E; Melikoglu, MA | 1 |
| Banko, A; Cirkovic, A; Despotovic, A; Grk, M; Jeremic, I; Lazarevic, I; Miljanovic, D | 1 |
| Hartikainen, S; Kauppi, M; Koponen, M; Paakinaho, A; Tiihonen, M; Tolppanen, AM | 1 |
| Gwinnutt, JM; Hyrich, KL; Sherbini, AA; Verstappen, SMM | 1 |
| Bolster, MB; Choi, HK; Lu, N; Smith, ID; Wei, J; Zhang, Y | 1 |
| Benaglio, F; Caporali, R; Carrara, G; Conigliaro, P; Di Franco, M; Fornaro, M; Govoni, M; Iannone, F; Iannuccelli, C; Lomater, C; Montecucco, C; Parisi, S; Raffeiner, B; Scirè, CA; Silvagni, E; Zanetti, A | 1 |
| Alperi-López, M; Calvo-Alén, J; Casamira, N; Castellví, I; de Agustín-de Oro, JJ; Escudero, A; García-Vicuña, R; González-Gay, MÁ; Hidalgo, C; Rubio, E; Sanmartí, R; Tornero-Molina, J | 1 |
| Aldaoseri, HA; Ali, NH; Riyadh Mohsen, E | 1 |
| Shimomura, T; Suzushima, H; Takaoka, H | 1 |
| Er, G; Fu, C; Ibrahim, J; Kaminskas, LM; Marasini, N; Skwarczynski, M; Subasic, CN; Toth, I; Whittaker, AK | 1 |
| Al Amoodi, A; Al Mazrouei, N; Alkaabi, M; Baraka, MA; Don, J; Elnour, AA; Farah, FH; Kidir, IY; Ramadan, A; Sadeq, A | 1 |
| Fujioka, T; Hosoya, T; Kubota, K; Kumaki, Y; Mori, M; Nakagawa, T; Oda, G; Ogawa, A; Onishi, I; Uetake, H | 1 |
| Esalatmanesh, K; Gadakchi, L; Ghassembaglou, A; Khabbazi, A; Nourmohammadi, F | 1 |
| Aikawa, NE; Araujo, CSR; Balbi, GGM; Bonfa, E; Bonfiglioli, KR; da Silva, HC; Domiciano, DS; Kallas, EG; Kupa, LVK; Medeiros-Ribeiro, AC; Nakai, TL; Pasoto, SG; Pedrosa, T; Saad, CGS; Shimabuco, AY; Silva, CA; Silva, MSR; Yuki, EFN | 1 |
| Amano, K; Atsumi, T; Fujino, Y; Fujio, K; Hirata, S; Iwai, H; Iwamoto, N; Kaneko, Y; Kawakami, A; Mimori, T; Miyamoto, T; Murakami, M; Nakano, K; Nakayamada, S; Nishimoto, N; Ohmura, K; Saito, K; Sumida, T; Takeuchi, T; Tanaka, Y; Tanimura, K; Yamaguchi, A; Yamanaka, H | 1 |
| Anchi, P; Godugu, C; Mahajan, RB; Panda, B | 1 |
| Aung, NY; Futakuchi, M; Ichikawa, C; Kabasawa, T; Kitaoka, T; Ohe, R; Saito, A; Sasaki, A; Suzuki, K; Takagi, M; Takahara, D; Takakubo, Y; Urano, Y; Utsunomiya, A; Yamakawa, M; Yamashita, D; Yang, S | 1 |
| Boers, M; de Jongh, J; Lammertsma, A; Lems, W; Ter Wee, M; van der Laken, C; van Schaardenburg, D; Verweij, N; Voskuyl, A; Yaqub, M; Zwezerijnen, G | 1 |
| Abada, A; Farkas, N; Hegyi, P; Helyes, Z; Juhász, MF; Kiss, F; Nagy, G; Szabó, L; Tóth, L | 1 |
| Ando, F; Fujita, S; Hanaoka, H; Nakajima, H; Suzuki, T; Takabayashi, K | 1 |
| Chruściak, T; Wisłowska, M | 1 |
| Aletaha, D; de la Torre, I; Haladyj, E; Lopez-Romero, P; Smolen, JS | 1 |
| Aikawa, NE; Araujo, CSR; Bonfa, E; Bonfiglioli, KR; Domiciano, DS; Kupa, LVK; Medeiros-Ribeiro, AC; Pasoto, SG; Pedrosa, T; Pereira, RMR; Saad, CGS; Shimabuco, AY; Silva, CA; Silva, MSR; Yuki, EFN; Zou, G | 1 |
| Choi, SE; Kang, JH; Lee, JK; Lee, SS; Park, DJ; Xu, H | 1 |
| Cao, Z; Huang, Q; Li, C; Liu, R; Liu, Y; Lu, A; Lu, C; Song, Y; Xue, Z; Yu, L; Zhang, Z; Zhu, D | 1 |
| Agewall, S; Eilertsen, GØ; Fagerland, MW; Feinberg, MW; Hjeltnes, G; Hokstad, I; Hollan, I; Mikkelsen, K; Mollnes, TE; Nguyen, THP | 1 |
| AlEjielat, R; Leelakanok, N; Methaneethorn, J | 1 |
| Chatzidionysiou, K; Jacobsen, S; Jensen, AK; Kostine, M; Kragstrup, TW; Leipe, J; Schäfer, VS; Sørensen, AS; Tenstad, HB; Torp, CK | 1 |
| Bessette, L; Kinch, CD; Kwok, K; Lukic, T; Mysler, E; On, PV; van Vollenhoven, RF | 1 |
| Strand, V | 1 |
| Amoura, Z; Arnaud, L; Burmester, GR; Cutolo, M; Damian, L; Fonseca, JE; Martin, T; Mouthon, L; Petitdemange, A; Rednic, S; Sztejkowski, C | 1 |
| Chayama, K; Fujitaka, K; Hamada, H; Hattori, N; Horimasu, Y; Ito, N; Iwamoto, H; Masuda, T; Miyamoto, S; Nakashima, T; Sakamoto, S; Yamaguchi, K | 1 |
| Chen, J; He, J; Jin, Y; Li, C; Li, R; Li, Y; Li, Z; Liu, H; Liu, T; Liu, X; Liu, Y; Miao, M; Ren, L; Shao, M; Su, Y; Sun, X; Yang, Y; Yao, H; Zhang, R; Zhang, X; Zhao, X; Zhou, Y | 1 |
| Adams, J; Barnes, N; Barrett, R; Batchelor, J; Culliford, D; Edwards, CJ; Fraser, SD; Holroyd, C; Howard, C; Ibrahim, K; Johnson, R; Lin, SX; Rischin, A; Roderick, P; Rutter, P; Stammers, M | 1 |
| Alten, R; Álvaro Gracia, JM; Bello, N; Fleischmann, R; Jia, B; Kaneko, Y; Quebe, A; Taylor, PC; Terres, JR; Walls, C | 1 |
| Fiaz, M; Gong, Z; He, Y; Liu, H; Pan, M; Xin, H; Yan, F; Zhou, M | 1 |
| de Jong, PHP; Looijen, AEM; van der Helm-van Mil, AHM; van Mulligen, E | 1 |
| Fukuda, M; Izutsu, H; Kaneko, Y; Kato, D; Rokuda, M; Takeuchi, T; Tanaka, Y; van der Heijde, D | 1 |
| Antono, D; Ariane, A; Hidayat, R; Kusumo Wibowo, SA; Musdalita, E; Rengganis, I; Shatri, H; Sumariyono, S | 1 |
| Chen, H; Sun, Y; Xu, X; Ye, Q | 1 |
| Asai, S; Fujibayashi, T; Hanabayashi, M; Hattori, Y; Hirano, Y; Imagama, S; Imaizumi, T; Ishikawa, H; Kanayama, Y; Kishimoto, K; Kojima, T; Oguchi, T; Ohashi, Y; Suzuki, M; Takahashi, N; Terabe, K; Yabe, Y | 1 |
| Badii, M; Darabian, S; Kur, J; Sayre, EC; Wade, JP; Wade, SD | 1 |
| Berenbaum, F; Combe, B; Constantin, A; Cosette, P; Gerard, B; Guillou, C; Hardouin, J; Lequerre, T; Rincheval, N; Vittecoq, O | 1 |
| Chakravarty, SD; Deodhar, A; Hsia, EC; Husni, ME; Kavanaugh, A; Leu, JH; Lo, KH; Schwartzman, S; Zhou, Y | 1 |
| Horák, P; Křístková, Z; Mann, H; Nekvindová, L; Pavelka, K; Skácelová, M; Vencovský, J; Závada, J | 1 |
| Ishiwada, N; Mori, S; Ueki, Y | 1 |
| Barton, A; Hyrich, KL; Isaacs, JD; Morgan, AW; Morris, AP; Nair, N; Oliver, J; Plant, D; Sutcliffe, M; Verstappen, SMM; Viatte, S; Wilson, AG | 1 |
| Bartlett, SJ; Bingham, CO; Cella, D; Gold, DA; Gruben, D; Murray, C; van Vollenhoven, R | 1 |
| Azuma, T; Hagiwara, T; Harigai, M; Hayashi, M; Higa, S; Higami, K; Himeno, S; Ikeda, K; Inoo, M; Inoue, E; Kadode, M; Kang, C; Kumon, Y; Kusaoi, M; Misaki, K; Nagaya, Y; Naniwa, T; Okano, T; Sawada, T; Shono, E; Suzuki, Y; Takeuchi, K; Tanaka, E; Yamada, S; Yamanaka, H; Yoshitama, T; Yoshizawa, Y | 1 |
| Fischer, N; Haas, JP; Hugle, B | 1 |
| Chijiwa, T; Sawada, N; Yoshii, I | 1 |
| Eder, A; Feuchtenberger, M; Kovacs, MS; Nigg, A; Schäfer, A | 2 |
| Goyal, L; Malode, A; Mathur, A; Yadav, R | 1 |
| Andreu, JL; Carmona, L; Loza, E; Otón, T; Rosario, MP | 1 |
| Högman, M; Larsson, A; Lind, A; Rönnelid, J; Weitoft, T | 1 |
| Ishii, T; Kajiwara, M; Kato, N; Munakata, Y; Sato, Y; Takahashi, T; Takahashi, Y; van Hoogstraten, H; Xu, C | 1 |
| Abe, M; Harigai, M; Ikari, K; Inoue, E; Ochiai, M; Saka, K; Sugano, E; Tanaka, E; Yamaguchi, R; Yamanaka, H | 1 |
| Baker, J; García-González, CM | 1 |
| Asai, S; Hattori, K; Imagama, S; Kishimoto, K; Kojima, M; Kojima, T; Ohashi, Y; Sobue, Y; Suzuki, M; Takahashi, N; Terabe, K | 1 |
| Chang, S; Chen, H; He, X; Zhu, S | 1 |
| Barrioni, BR; Corrêa, JD; Cunha, FQ; de Arruda, JAA; Duffles, LF; Fernandes, GR; Fukada, SY; Graves, DT; Macari, S; Machado, CC; Medeiros, JD; Nakaya, HTI; Oliveira, SR; Santos, MS; Schneider, AH; Silva, TA; Singh, Y | 1 |
| Colhoun, HM; Hollick, RJ; McAllister, DA; McKeigue, PM; Porter, D; Ralston, SH | 1 |
| Ha, YJ; Kang, EH; Lee, EB; Lee, JH; Lee, YJ; Shin, A | 1 |
| Chen, SK; Desai, RJ; Gautam, N; Glynn, RJ; He, M; Kim, SC; Lee, H; Vine, SM; Weinblatt, ME | 1 |
| Cao, W; Sun, C; Wang, M; Wang, X; Wang, Y; Wu, J | 1 |
| Cao, W; Li, Y; Liu, H; Ma, T; Wang, Q; Wei, F; Yang, X; Zhao, W; Zheng, L | 1 |
| Dubiel-Braszczok, B; Engelmann, M; Gumkowska-Sroka, O; Kotyla, PJ; Nowak, K; Owczarek, A | 1 |
| Kaneko, Y; Kato, D; Kokubo, S; Sakurai, M; Snijder, R | 1 |
| Chen, S; Chen, Y; Liu, L; Liu, X; Yan, Y | 1 |
| Allaart, CF; Baudoin, P; Boers, M; Bos, R; Buttgereit, F; Cutolo, M; Da Silva, JA; Griep, EN; Hartman, L; Klaasen, R; Klausch, LT; Kok, MR; Lems, WF; Masaryk, P; Opris-Belinski, D; Paolino, S; Raterman, HG; Schilder, AM; Szekanecz, Z | 1 |
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| Askling, J; Barbulescu, A; Frisell, T; Kim, SC; Saevarsdottir, S | 1 |
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| Boyce, EG; C Lui, M; Rogan, EL | 1 |
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| Bykerk, VP; Jannat-Khah, DP; Jivanelli, B; Meng, CF; Rajesh, DA | 1 |
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| Kao, WC; Lee, YH; Liu, CT; Ma, KS | 1 |
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| Ahmed, A; Arundel, C; Cheng, Y; Dowell, S; Faselis, C; Fletcher, RD; Fonarow, GC; Heimall, MS; Joseph, JK; Karasik, PE; Kerr, GS; Liappis, AP; Moore, HJ; Quiñones, ME; Sheriff, HM; Taub, DD; Zeng-Treitler, Q; Zhang, S | 1 |
| Mar, VJ; Wang, C; Wluka, AE; Wolfe, R; Yan, MK | 1 |
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| Andreica, I; Anft, M; Babel, N; Baraliakos, X; Blazquez-Navarro, A; Kiltz, U; Pfaender, S; Sokolar, J; Stervbo, U; Vidal Blanco, E; Westhoff, T | 1 |
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| Dai, LY; Zhao, JX | 1 |
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| Cen, H; Chen, CJ; Huang, H; Jin, T; Qin, W; Wang, TH; Wen, QW; Wu, XD; Yu, H; Zeng, Z; Zhang, HQ | 1 |
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| Kameda, H; Kato, N; Praestgaard, A; Takahashi, T; Tanaka, Y; Van Hoogstraten, H | 1 |
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| Aletaha, D; Balsa, A; Bathon, JM; Bergstra, SA; Buch, MH; Burmester, GR; Buttgereit, F; Caporali, R; Cardiel, MH; Chatzidionysiou, K; Codreanu, C; Cutolo, M; de Souza, S; den Broeder, AA; Edwards, CJ; El Aoufy, K; Finckh, A; Fonseca, JE; Gottenberg, JE; Haavardsholm, EA; Hyrich, KL; Iagnocco, A; Kerschbaumer, A; Landewé, RBM; Lauper, K; Li, Z; McInnes, IB; Mysler, EF; Nash, P; Poor, G; Pope, JE; Ristic, GG; Rivellese, F; Rubbert-Roth, A; Schulze-Koops, H; Sepriano, A; Smolen, JS; Stamm, TA; Stoilov, N; Strangfeld, A; Takeuchi, T; van der Heijde, D; van der Helm-van Mil, A; van Duuren, E; Verschueren, P; Vliet Vlieland, TPM; Westhovens, R; Winthrop, KL | 1 |
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| Chang, SH; Choe, JY; Chung, SW; Ha, YJ; Kang, EH; Kim, JW; Kim, MU; Lee, EY; Lee, JS; Lee, YA; Park, CH; Park, YB; Pyo, JY | 1 |
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| Arakawa, F; Hosoi, H; Iwamoto, R; Kosako, H; Matsumoto, A; Murata, S; Murata, SI; Mushino, T; Nakao, N; Ohshima, K; Sakaki, A; Sonoki, T; Tanaka, K; Yamoto, T | 1 |
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| Bijlsma, JWJ; de Hair, MJH; Jacobs, JWG; Jurgens, MS; Lafeber, FPJG; Safy-Khan, M; Sasso, EH; Tekstra, J; Welsing, PMJ | 1 |
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| England, BR; Johnson, TM; Luedders, BA; Mikuls, TR; O'Dell, JR; Sayles, H; Thiele, GM | 1 |
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| Huizinga, TWJ; Matthijssen, XME; Niemantsverdriet, E; van der Helm-van Mil, AHM | 1 |
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| Honda, N; Kawano, H; Kubo, M; Matsuura, T; Nawata, T; Shiragami, K; Yano, M | 1 |
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| Bao, CD; Chen, JW; He, DY; Hu, JK; Ji, F; Jiang, LD; Li, CG; Li, JY; Li, XF; Li, XP; Li, ZG; Li, ZJ; Liu, MR; Liu, Y; Wang, GC; Xiao, ZY; Xin, XF; Xu, J; Xu, JH; Yang, Y; Zhang, X; Zuo, XX | 1 |
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| Abramson, SB; Alexander, M; Artacho, A; Flor-Duro, A; Gulko, P; Homsi, Y; Isaac, S; Izmirly, P; Koo, I; Manasson, J; Nayak, R; Patterson, A; Pineda-Lucena, A; Pons, J; Puchades-Carrasco, L; Rosenthal, P; Scher, JU; Smith, PB; Turnbaugh, PJ; Ubeda, C | 1 |
| Asai, S; Hanabayashi, M; Hirano, Y; Ishiguro, N; Ishikawa, H; Kanayama, Y; Kaneko, A; Kato, T; Kobayakawa, T; Kojima, T; Nishiume, T; Sobue, Y; Suzuki, M; Takahashi, N; Terabe, K; Watanabe, T; Yabe, Y; Yokota, Y; Yoshioka, Y | 1 |
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| Citera, G; Cordeiro, L; de Los Ángeles Correa, M; Federico, A; Gonzalez, E; Klimovsky, E; Lago, N; Lazaro, MA; Mysler, E; Pardo Hidalgo, R; Scheines, E; Siri, D; Spindler, A; Strusberg, I; Tate, P; Velasco Zamora, J; Venarotti, H | 1 |
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| de la Torre, I; Durez, P; Emery, P; Holzkämper, T; Hueber, AJ; Larsson, E; Tanaka, Y | 1 |
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| Calvo-Gutiérrez, J; Cárdenas, MJ; Castro-Villegas, MC; Collantes-Estévez, E; de la Fuente, S; Del Prado, JR; Escudero-Contreras, A; Font, P; Romero-Gómez, M; Ruiz-Vílchez, D | 1 |
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| Balanescu, A; Cen, L; Cohen, SB; Gomez-Reino, J; Kivitz, A; Scheinberg, M; Shisha, T; Smolen, JS; Tony, HP; Zhu, P | 1 |
| Bijlsma, JWJ; Jacobs, JWG; Rubbert-Roth, A; Welsing, PMJ | 1 |
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| Bingham, CO; Burmester, GR; Bykerk, VP; Cioffi, C; Ecoffet, C; Emery, P; Furst, DE; Mariette, X; van der Heijde, D; van Vollenhoven, R; VanLunen, B; Weinblatt, ME | 1 |
| Buisman, LR; Hazes, JM; Kuijper, TM; Weel, AE | 1 |
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| Barton, A; Bluett, J | 1 |
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| Bijlsma, JWJ; Borm, MEA; Jacobs, JWG; Lafeber, FPJ; Mokry, M; Pethö-Schramm, A; Teitsma, XM; van Laar, JM | 1 |
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| Bananis, E; Chen, C; Curtis, JR; Fan, H; Hirose, T; Lindsey, S; Mendelsohn, AM; Nduaka, CI; Tanaka, Y; Valdez, H; Wang, L; Winthrop, KL; Yamaoka, K | 1 |
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| Bernal, JA; Bort-Marti, S; Burls, A; Cabello, JB; Ruiz Garcia, V; Vela Casasempere, P | 1 |
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| Davarpanah, I; Haak, R; Jäger, J; Krohn-Grimberghe, B; Mausberg, RF; Sack, U; Schmalz, G; Schmidt, J; Ziebolz, D | 1 |
| Carmack, T; DeLozier, AM; Durez, P; Fleischmann, R; Gaich, CL; Hidalgo, RP; Kuo, WL; Rooney, T; Schiff, M; Schlichting, D; Shaikh, S; Takeuchi, T; van Vollenhoven, R; Won, JE; Zerbini, CAF | 1 |
| Cheng, X; Lee, RJ; Li, Y; Liu, J; Sun, F; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M | 1 |
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| Albulescu, M; Burmester, GR; Close, D; Godwood, A; Guo, X; Kremer, JM; McInnes, IB; Miranda, P; Ryan, PC; Vencovsky, J; Weinblatt, ME; White, WI | 1 |
| Everts-Graber, J; Finckh, A; Florentinus, S; Kupper, H; Li, Y; Möller, B | 1 |
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| Allaart, CF; Bergstra, SA; Huizinga, TWJ; Landewé, RBM | 1 |
| Akdemir, G; Allaart, CF; Bergstra, SA; Collée, G; Landewé, RBM; Olivas, O; Riyazi, N; van Groenendael, JHLM | 1 |
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| de Jong, P; Hazes, J; Kuijper, TM; Luime, JJ; Tchetverikov, I; van der Lubbe, P; van Zeben, D; Weel, A; Xiong, H | 1 |
| Akdemir, G; Allaart, CF; Bergstra, SA; de Sonnaville, PBJ; Goekoop, RJ; Grillet, BAM; Heimans, L; Huizinga, TWJ; Lard, LR; Peeters, AJ; Steup-Beekman, GM; van Groenendael, JHLM; van Oosterhout, M | 1 |
| Schaeverbeke, T; Scherlinger, M; Truchetet, ME | 1 |
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| Bijlsma, JWJ; Borm, MEA; Denissen, NHAM; Hendriks, L; Jacobs, JWG; Lafeber, FPJG; Pethö-Schramm, A; Teitsma, XM; van Laar, JM; Welsing, PMJ | 1 |
| Amano, K; Hatta, K; Kanazawa, T; Kume, K; Kuwaba, N; Ohta, H; Yamada, S | 2 |
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| Baranauskaite, A; Choe, JY; Ciferska, H; Dokoupilova, E; Jedrychowicz-Rosiak, K; Lee, Y; Mekic, M; Niebrzydowski, J; Porawska, W; Prodanovic, N; Rho, YH; Smolen, JS; Staykov, I; Yatsyshyn, R; Zielinska, A | 1 |
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| Bombardier, C; Hazlewood, GS; Marshall, D; Tomlinson, G | 1 |
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| Gan, Z; Liu, HM; Wu, H; Wu, HH; Yan, F; Zhou, MJ | 1 |
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| Hsia, E; Jaller, JJ; Jeka, S; Jia, B; Kitumnuaypong, T; Louthrenoo, W; Mann, H; Matsievskaia, G; Mease, PJ; Nie, J; Soriano, ER; Wang, C | 1 |
| Acevedo-Vásquez, EM; Alarcón-Riquelme, ME; Alvarellos, A; Babini, A; Ballesteros, F; Berbotto, G; Cardiel, MH; Catoggio, LJ; Citera, G; Eimon, A; Esquivel-Valerio, JA; García de la Torre, I; García, CG; Goñi, M; Graf, C; Maradiaga-Ceceña, MA; Marcos, JC; Messina, OD; Miranda, P; Moreno, JLC; Musuruana, JL; Nasswetter, G; Paira, S; Pellet, AC; Pons-Estel, BA; Quinteros, A; Sacnún, M; Sánchez, E; Scherbarth, H; Spindler, A; Strusberg, I; Tate, G; Toloza, S; Tusié-Luna, T | 1 |
| Scott, LJ | 1 |
| Bijlsma, JWJ; Borm, MEA; Jacobs, JWG; Lafeber, FPJG; Pethö-Schramm, A; Teitsma, XM; van Laar, JM; Welsing, PMJ | 1 |
| Du, SG; Guo, ZH; Kong, QQ; Liu, YM; Wang, XC; Zhou, SL | 1 |
| Bi, L; Chen, J; Chen, Q; Cui, X; Da, Z; Fang, Y; Gong, L; He, D; Hu, S; Huang, C; Jiang, L; Jiang, Q; Leng, X; Li, L; Li, Q; Li, R; Li, X; Li, Y; Li, Z; Liu, C; Liu, X; Qi, W; Song, H; Su, Y; Sun, L; Wang, G; Wang, X; Wang, Y; Wu, H; Wu, L; Xiao, W; Xu, J; Zhang, F; Zhang, L; Zhang, W; Zhang, Z; Zhao, D; Zhu, H | 1 |
| Alten, R; Nitschmann, S | 1 |
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| Labuda, SM; Schieffelin, JS; Shaffer, JG; Stryjewska, BM | 1 |
| Burton, M; Carlsen, AL; Ellingsen, T; Heegaard, NHH; Hetland, ML; Hørslev-Petersen, K; Johansen, JS; Junker, P; Krintel, SB; Sode, J; Stengaard-Pedersen, K; Østergaard, M | 1 |
| Bananis, E; Burmester, GR; Charles-Schoeman, C; Connell, CA; Fan, H; Fleischmann, R; Kwok, K; Nash, P; van der Heijde, D; Zerbini, CAF | 1 |
| Chen, S; Emery, P; Fleischmann, R; Florentinus, S; Guérette, B; Kavanaugh, A; Kupper, H; Sainsbury, I; Smolen, JS; van Vollenhoven, RF | 1 |
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| Filotico, M; Filotico, R | 1 |
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| Edwards, CJ; Kiely, P; Naisbett-Groet, B; Östör, AJK | 1 |
| Allaart, CF; Bergstra, SA; Chopra, A; Govind, N; Huizinga, TWJ; Landewe, RBM; van den Berg, R | 1 |
| Fujibayashi, S; Furu, M; Hashimoto, M; Ito, H; Lyman, S; Masamoto, K; Matsuda, S; Mimori, T; Otsuki, B; Shima, K; Tanaka, M; Tanida, S; Yoshitomi, H | 1 |
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| Aota, Y; Fujiwara, K; Gotoh, A; Honda, T; Kimura, S; Nonaka, T; Okuda, Y; Sakurai, M; Wakabayashi, Y; Watanabe, T; Yokoyama, T | 1 |
| Aras, GA; Chung, J; Collier, DH; Curtis, JR; Emery, P; Haraoui, B; Park, GS; Trivedi, M | 1 |
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| Chen, S; Fan, S; Liu, G; Qin, A; Sun, X; Tang, P; Xie, Z; Zhang, J; Zhu, P | 1 |
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| Acuña-Ochoa, JG; Bernardes, M; Conde, C; Ferreiro-Iglesias, A; Gonzalez, A; Gonzalez-Alvaro, I; Lima, A; López-Rodríguez, R; Mera-Varela, A; Narvaez, J; Paradowska-Gorycka, A; Pawlik, A; Pérez-Pampín, E; Slezak, R; Świerkot, J; Vidal-Bralo, L | 1 |
| Eso, Y; Katsuragi, K; Matsuura, M; Sawada, K; Seno, H; Shirakawa, K; Uza, N | 1 |
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| Bermejo, I; Martyn-St James, M; Ren, S; Scott, DL; Stevenson, M; Uttley, L; Wong, R; Young, A | 1 |
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| Bergström, B; Carlsten, H; Ekwall, AH | 1 |
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| Cui, XJ; Jia, QY; Liang, QQ; Liu, L; Shi, Q; Wang, Q; Wang, XY; Wang, YJ; Wang, YR; Xu, CQ; Yao, M | 1 |
| Tseng, WY; Williams, RO | 1 |
| Genovese, M; Harrison, P; Kavanaugh, A; Meuleners, L; Tasset, C; Van der Aa, A; Westhovens, R | 1 |
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| Abrahamowicz, M; Bernatsky, S; Curtis, JR; Guerra, SF; Machado, MAÁ; Moura, CS | 1 |
| Choi, Y; Ha, YJ; Lee, EB; Lee, EY; Lee, YJ; Park, JK; Shin, K; Song, YW; Winthrop, KL | 1 |
| Birchwood, C; Gill, D; Kremer, JM; Michalska, M; Pei, J; Reiss, W; Rigby, W; Singer, NG | 1 |
| Barvik, I; Dosedel, M; Duintjer Tebbens, J; Kubena, AA; Nekvindova, J; Pavek, P; Soukup, T; Veleta, T | 1 |
| Arai, H; Azukizawa, M; Furu, M; Hanai, A; Hashimoto, M; Ito, H; Matsuda, S; Mimori, T; Morita, Y; Tanaka, M; Torii, M | 1 |
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| Amital, H; Durez, P; Garcia-Kutzbach, A; Govoni, M; Lazaro, MA; Moots, RJ; Pavelka, K; Vastesaeger, N | 1 |
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| Bananis, E; Bergman, MJ; Dikranian, A; Lee, EB; Strand, V; Takiya, L; Wilkinson, B; Yazici, Y; Zang, C | 1 |
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| Glushkova, N; Goremykina, M; Ivanova, R; Vento, S | 1 |
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| Harada, S; Harigai, M; Hirano, F; Kasai, S; Kihara, M; Koike, R; Miyasaka, N; Nagasaka, K; Sakai, R; Tsutsumino, M; Yamanaka, H; Yokoyama, W | 1 |
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| Fujiwara, M; Kanazawa, Y; Kato, S; Leppold, C; Morita, T; Ochi, S; Oikawa, T; Shineha, R; Tsubokura, M | 1 |
| Allaart, CF; Aslibekyan, S; Böhringer, S; Eektimmerman, F; Guchelaar, HJ; Swen, JJ | 1 |
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| Fujii, T; Harigai, M; Kameda, H; Kanbe, K; Koike, R; Nakajima, A; Sagawa, A; Suzuki, Y; Tomita, T | 1 |
| Bodycombe, D; Curtis, JR; Dyagilev, K; Kan, HJ; Kharrazi, H; Molta, CT; Saria, S; Schulam, P | 1 |
| Ando, K; Carreras, J; Hiraiwa, S; Ikoma, H; Kondo, Y; Miura, I; Miyaoka, M; Nakamura, N; Roncador, G; Sato, S; Shiraiwa, S; Suzuki, Y; Tomita, S; Yukie Kikuti, Y | 1 |
| Acuña Ochoa, JG; Bernardes, M; Cáliz, R; Conde, C; Dolžan, V; Ferreiro-Iglesias, A; Gómez-Reino, JJ; González, A; González-Álvaro, I; Lima, A; López-Rodríguez, R; Mera-Varela, A; Narváez, J; Paradowska-Gorycka, A; Pawlik, A; Pérez-Pampín, E; Slezak, R; Świerkot, J; Vidal-Bralo, L | 1 |
| Fan, C; Genovese, MC; Graham, NMH; Huizinga, TWJ; Mangan, EK; Parrino, J; Spindler, A; van Adelsberg, J; van der Heijde, D; van Hoogstraten, H | 1 |
| Bijlsma, JWJ; Borm, MEA; de Jong, PHP; Hazes, JMW; Jacobs, JWG; Lafeber, FPJG; Pethö-Schramm, A; Teitsma, XM; van Laar, JM; Weel, AEAM; Welsing, PMJ | 2 |
| Cheng, IT; Kun, EW; Kwok, KY; Lao, VW; Lau, XS; Lee, AP; Lee, VK; Li, EK; Li, TK; Mak, QW; Pang, SH; Shang, Q; Tam, LH; Tam, LS; Wong, PC; Yim, IC; Yip, RM; Zhu, TY | 1 |
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| Dodanwala, H; Feger, DM; June, RR; Longson, N; Olsen, NJ; Ostrov, BE | 1 |
| Agakov, F; Arnett, D; Aslibekyan, S; Barnes, MR; Barrett, JH; Barton, A; Bongartz, T; Bridges, SL; Colombo, M; Cope, AP; Cordell, HJ; de Hair, MJH; Emery, P; Freeston, JE; Isaacs, JD; Kubo, M; Massey, J; McInnes, IB; McKeigue, P; Mifsud, B; Morgan, AW; Morgan, M; Mushiroda, T; Nam, JL; Orchard, P; Padyukov, L; Pitzalis, C; Plant, D; Porter, D; Scott, IC; Spiliopoulou, A; Strathdee, JL; Tak, PP; Taylor, JC; Twigg, S; van Vollenhoven, RF; Verstappen, SMM; Wang, J; Weinshilboum, R | 1 |
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| Lund, M; Melbye, M; Pasternak, B; Svanström, H | 1 |
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| Brands, R; Chandrupatla, DMSH; Elshof, E; Hammond, A; Jansen, G; Lammertsma, AA; Low, PS; Matsuyama, T; Molthoff, CFM; Musters, RJP; Ritsema, WIGR; van der Laken, CJ; Vos, R; Windhorst, AD | 1 |
| Chen, KL; Li, XF; Luo, J; Niu, HQ; Qin, KL; Zhao, WP; Zhao, XC | 1 |
| Weinblatt, ME | 10 |
| Amano, K; Hirata, S; Inoo, M; Kaneko, Y; Kato, M; Kobayashi-Haraoka, H; Miyasaka, N; Miyata, M; Murakawa, Y; Takeuchi, T; Tanaka, E; Tanaka, Y; Yamamoto, K; Yamanaka, H; Yasuoka, H | 1 |
| Cha, HS; Choi, MS; Eun, Y; Jeong, H; Kim, H; Kim, IY; Koh, E; Lee, J | 1 |
| Ebisawa, K; Funamizu, K; Koya, J; Kurokawa, M; Miyagaki, T; Nakamura, R; Oka, T; Sato, S; Sugaya, M | 1 |
| Aelion, JA; Chen, K; Genovese, MC; Khan, NS; Khatri, A; Li, Y; Mansikka, HT; Othman, AA; Padley, RJ; Peloso, PM; Weinblatt, ME | 1 |
| Aldayel, AM; Cui, Z; Li, X; Mustafa, BE; O'Mary, HL; Thakkar, SG; Valdes, SA | 1 |
| Atzeni, F; Batticciotto, A; Ditto, MC; Gerardi, MC; Sarzi-Puttini, P; Talotta, R | 1 |
| Gafter-Gvili, A; Klein, A; Polliack, A | 1 |
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| Chen, SY; Qin, Y; Zhou, P | 1 |
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| Bourret, JA; Claxton, L; Gerber, RA; Soonasra, A; Taylor, M | 1 |
| Brown, S; Buch, MH; Davies, C; Dawkins, B; Emery, P; Everett, CC; Hulme, C; McCabe, C; Naraghi, K; Pavitt, S; Sharples, L | 1 |
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| Barber, CE; Barnabe, C; Bykerk, V; Choi, MY; Hazlewood, GS; Pope, JE | 1 |
| Combe, B; Fleischmann, R; Genovese, MC; Hall, S; Meerwein, S; Mohamed, MF; Pangan, AL; Rubbert-Roth, A; Zhang, Y; Zhou, Y | 1 |
| Bessette, L; Burmester, GR; Camp, HS; Kivitz, A; Kremer, JM; Li, Y; Othman, AA; Pangan, AL; Van den Bosch, F; Zhou, Y | 1 |
| Burmester, GR; Chen, CI; Gossec, L; Guillonneau, S; Kimura, T; Lin, Y; Mangan, EK; Proudfoot, CWJ; Reaney, M; Strand, V; van Adelsberg, J; van Hoogstraten, H | 1 |
| Irie, T; Kanno, T; Kimura, S; Migita, K; Odajima, H; Suzuki, E | 1 |
| Lee, RJ; Li, Y; Sun, F; Sun, X; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M; Zhou, Y | 1 |
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| Hsu, B; Hu, C; Sharma, A; Xu, Y; Xu, Z; Zhang, L; Zhou, H; Zhuang, Y | 1 |
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| Barrett, R; Bird, P; Button, P; Griffiths, H; Littlejohn, G; Nicholls, D; Roberts, L; Truman, M; Tymms, K | 1 |
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| Ahlquist, P; Ammitzbøll, C; Bolce, R; Brahe, CH; Dam, MY; Defranoux, N; Ellingsen, T; Hansen, I; Hetland, ML; Hørslev-Petersen, K; Johansen, JS; Junker, P; Jørgensen, A; Krintel, SB; Linauskas, A; Lindegaard, H; Lottenburger, T; Raun, J; Sasso, EH; Schlemmer, A; Stengaard-Pedersen, K; Wang, X; Ørnbjerg, LM; Østergaard, M | 1 |
| Barclay, M; Chapman, PT; Drake, J; Frampton, C; OʼDonnell, JL; Stamp, LK; Zhang, M | 1 |
| Anderson, J; Barton, A; Hope, HF; Hyrich, KL; Kopec-Harding, K; Sergeant, JC; Symmons, DPM; Verstappen, SMM | 1 |
| Curtis, JR; Fireman, B; Goldfien, R; Herrinton, LJ; Liu, L; Ray, GT; Wu, JJ | 2 |
| Ando, T; Kassai, Y; Kondo, Y; Kurisu, R; Miyazaki, T; Morita, R; Murota, A; Nakayama, Y; Okuzono, Y; Suzuki, K; Takeshita, M; Takeuchi, T; Takiguchi, M; Tasaki, S; Toyoshiba, H; Yamaoka, K; Yasuoka, H; Yoshimoto, K; Yoshimura, A | 1 |
| Aelion, JA; Chen, K; Genovese, MC; Khatri, A; Leszczynski, P; Li, Y; Liu, J; Mansikka, HT; Mease, PJ; Othman, AA; Peloso, PM; Weinblatt, ME | 1 |
| Adami, S; Batticciotto, A; De Lucia, O; Filippucci, E; Grassi, W; Idolazzi, L; Kumke, T; Meroni, PL; Sarzi-Puttini, P; Talavera, P | 1 |
| Panush, RS; Tran, HW | 1 |
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| Bodakçi, E; Cansu, DÜ; Korkmaz, C; Teke, HÜ | 1 |
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| Chen, S; Florentinus, S; Kavanaugh, A; Smolen, JS; Suboticki, JL; van Vollenhoven, RF | 1 |
| de la Torre, I; De Leonardis, F; Durez, P; Fleischmann, R; López-Romero, P; Meszaros, G; Nantz, E; Naredo, E; Schett, G; Schlichting, D; van der Heijde, D; Østergaard, M | 1 |
| Cronstein, B; Friedman, B | 1 |
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| Tabata, C; Tabata, R; Takei, Y; Uesugi, H | 1 |
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| Cardiel, MH; Cohen, S; Connell, CA; Fleischmann, R; Gruben, D; Keystone, E; Kremer, J; Nash, P; Song, YW; Strand, V; Tanaka, Y; Tegzová, D; van der Heijde, D; Wallenstein, G; Zerbini, CAF | 1 |
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| Chen, MH; Chen, WS; Chou, CT; Lai, CC; Liao, HT; Tsai, CY; Wang, KC | 1 |
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| Choi, Y; Lee, EB; Park, JK; Song, YW; Winthrop, KL | 1 |
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| Amano, K; Higashi, M; Kimura, Y; Kizaki, M; Momose, S; Mori, T; Okamoto, S; Saito, S; Shimizu, T; Suzuki, K; Takeuchi, T; Tamaru, JI; Tokuhira, M | 1 |
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| Dellaripa, PF; Doyle, TJ; Fletcher, EA; Friedlander, HM; Frits, ML; Gill, RR; Hatabu, H; He, X; Huang, J; Iannaccone, CK; Karlson, EW; Lu, B; Mahmoud, TG; Murphy, DJ; Nishino, M; Rosas, IO; Shadick, NA; Sparks, JA; Weinblatt, ME; Zaccardelli, A | 1 |
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| Camp, HS; Cohen, S; Damjanov, N; Emery, P; Friedman, A; Othman, AA; Pangan, AL; Rigby, W; Smolen, JS; Tanaka, Y; Vargas, JI; Zhang, Y | 1 |
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| Ahmed, S; Bandopadhyay, S; Bandyopadhyay, N; Pal, RS; Pal, Y | 1 |
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| Matsuda, R; Miyaza, S; Motoyama, Y; Nakagawa, I; Nakamura, M; Nakase, H | 1 |
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| Baillet, A; Berenbaum, F; Bernardy, C; Courtier, A; Gaudin, P; Lejeune, S; Nguyen, MVC; Paclet, MH; Wendling, D | 1 |
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| Andrews, J; Bissell, LA; Buch, MH; Burska, AN; Conaghan, PG; Donica, H; Emery, P; Hensor, EMA; Keen, H; Kozera, L; Mackie, SL; Morgan, AW; Mortimer, I; Nam, JL; Villeneuve, E | 1 |
| Guan, Y; Kremer, JM; Pappas, DA; Parker, SCJ; Quang, D; Wang, Z; Zhang, H; Zhu, F | 1 |
| Escudero-Castellanos, A; Ferro-Flores, G; Gibbens-Bandala, BV; Isaac-Olive, K; Morales-Avila, E; Ocampo-García, BE; Trujillo-Nolasco, RM | 1 |
| Iwasaki, M; Izutsu, H; Kaneko, Y; Katayama, K; Kawakami, A; Rokuda, M; Shiomi, T; Takeuchi, T; Tanaka, S; Tanaka, Y; Ushijima, S; van der Heijde, D; Yamada, E | 1 |
| Bessette, L; Durez, P; Enejosa, JV; Fleischmann, RM; Genovese, MC; Li, Y; Mysler, E; Ostor, A; Peterfy, C; Song, IH | 1 |
| Hara, A; Hara, S; Ishii, H; Ishimatsu, Y; Ishimoto, H; Kadota, JI; Kakugawa, T; Kido, T; Kobayashi, T; Kushima, H; Miyamura, T; Mukae, H; Nakashima, S; Noguchi, S; Obase, Y; Okuno, D; Sakamoto, N; Soejima, Y; Yamaguchi, H; Yatera, K; Yoshioka, S; Yura, H | 1 |
| Desai, RJ; Jin, Y; Kang, EH; Kim, SC; Tong, AY | 1 |
| Bann, CM; Coker-Schwimmer, E; Donahue, KE; Gartlehner, G; Jonas, BL; Patel, SV; Schulman, ER; Viswanathan, M; Weber, RP | 1 |
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| Huang, Z; Wu, H; Wu, S; Xi, L; Zhu, Y; Zhu, Z | 1 |
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| Ezaki, T; Imamura, F; Koga, Y; Mori, S; Sugimoto, M; Uramoto, H | 1 |
| Ahlquist, P; Ammitzbøll, CG; Dam, MY; Ellingsen, T; Hansen, I; Hetland, ML; Horn, HC; Hørslev-Petersen, K; Johansen, JS; Junker, P; Jørgensen, A; Krintel, SB; Linauskas, A; Lindegaard, H; Pødenphant, J; Raun, J; Schlemmer, A; Stengaard-Pedersen, K; Østergaard, M | 1 |
| Frey, N; Grange, S; Levi, M | 1 |
| Caporali, R; Montecucco, C; Sakellariou, G; Scirè, CA; Zambon, A | 1 |
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| Almon, RR; DuBois, DC; Jusko, WJ; Liu, DY; Lon, HK; Wang, YL | 1 |
| Chen, D; Emery, P; Fan, H; Fleischmann, RM; Hsia, EC; Mack, M; Wagner, C | 1 |
| Bathon, JM; Bridges, SL; Charles-Schoeman, C; Chen, L; Cofield, SS; Curtis, JR; Dell'Italia, LJ; Moreland, LW; Navarro-Millán, I; O'Dell, JR; Paulus, HE; Yang, S | 1 |
| Barbhaiya, M; Solomon, DH | 1 |
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| Barclay, ML; Dalrymple, JM; Drake, J; Duffull, SB; Korell, J; Stamp, LK; Zhang, M | 1 |
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| Fujisaki, T; Kondo, S; Okamura, S; Oshiro, Y; Suematsu, E; Takeshita, M; Tamura, K; Tanimoto, K; Yamada, K; Yoshimoto, G | 1 |
| Forslind, K; Geborek, P; Petersson, IF; Rezaei, H; Saevarsdottir, S; van Vollenhoven, RF | 1 |
| Countryman, PJ; DiCarlo, JC; Gaylis, NB; Merrill, JT; Olech, E; Peterfy, CG | 1 |
| Hakozaki, Y; Horikoshi, H; Kikuchi, Y; Kimura, F; Kobayashi, A; Kobayashi, S; Kondo, T; Masuoka, K; Matsuki, Y; Matsukuma, S; Nagumo, M; Oshima, S; Sato, K | 1 |
| Fernández de la Puebla-Giménez, RA; García-Olid, B; Guirao-Arrabal, E; Muñoz-López, C | 1 |
| Byng-Maddick, R; Penn, H; Wijendra, M | 1 |
| Ando, Y; Hirota, T; Ieiri, I; Ishii, K; Matsumoto, N; Morimoto, T; Ohashi, K; Oribe, M; Otsuka, E; Shimada, H | 1 |
| Arnett, DK; Aslibekyan, S; Baggott, JE; Bridges, SL; Brown, EE; Curtis, JR; Mikuls, TR; Moreland, LW; Morgan, S; O'Dell, JR; Redden, DT; Reynolds, RJ; Sha, J | 1 |
| Allaart, CF; Dirven, L; Huizinga, TW; Kerstens, PJ; Kloppenburg, M; Kroon, HM; Lems, WF; Peeters, AJ; Ronday, HK; van den Broek, M | 1 |
| Cannon, GW; Caplan, L; Davis, LA; Haverhals, LM; Johnson, DS; Kerr, GS; Mikuls, TR; Pointer, LF; Prochazka, A; Reimold, AM; Richards, JS; Valuck, R; Wolff, RK | 1 |
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| Arakawa, F; Ichikawa, A; Ishibashi, Y; Kimura, Y; Kiyasu, J; Miura, O; Miyoshi, H; Nakashima, S; Niino, D; Ohshima, K; Sato, K; Sugita, Y; Takeuchi, M; Yoshida, M | 1 |
| Lindberg, M | 1 |
| Bridges, SL; Cofield, SS; Curtis, JR; McVie, T; Mikuls, TR; Moreland, LW; Navarro-Millán, I; O'Dell, J; Ranganath, VK; Reynolds, RJ | 1 |
| Benichou, O; Berclaz, PY; Disch, D; Genovese, MC; Lee, E; Myers, S; Satterwhite, J; Sides, G; Veenhuizen, M | 1 |
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| de Waal Malefijt, MC; den Broeder, AA; Fransen, J; Kievit, W; van Riel, PL | 1 |
| Abrahamsen, B; Andersen, LS; Ellingsen, T; Hansen, I; Hansen, MS; Hetland, ML; Hyldstrup, L; Hørslev-Petersen, K; Jensen, TW; Junker, P; Jurik, AG; Langdahl, B; Lauridsen, UB; Lindegaard, H; Lottenburger, T; Pedersen, JK; Pødenphant, J; Skjødt, H; Stengaard-Petersen, K; Svendsen, AJ; Tarp, U; Vestergaard, A; Zerahn, B; Østergaard, M | 1 |
| Bananis, E; Damjanov, N; Fabo, T; Jones, H; Koenig, AS; Kotak, S; Majdan, M; Mazurov, V; Nasonov, E; Pavelka, K; Szekanecz, Z; Szumski, A; Tang, B; Vasilescu, R | 1 |
| Alvarez-Lario, B; Colazo-Burlato, M; Macarrón-Vicente, J; Prieto-Tejedo, R | 1 |
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| Schmalzing, M | 2 |
| Bridges, SL; Cofield, SS; Curtis, JR; Mikuls, TR; Moreland, LW; O'Dell, JR; Ranganath, VK | 1 |
| Abello-Banfi, M; Gutierrez-Ureña, S; Hrycaj, P; Jimenez, R; Kim, H; Kovalenko, V; Lee, SJ; Miranda, P; Morales-Olazabal, L; Müller-Ladner, U; Park, W; Piotrowski, M; Prodanovic, N; Ramiterre, E; Shevchuk, S; Tee, M; Yoo, DH; Zamani, O | 1 |
| Fukushima, M; Katayama, Y; Kotani, A; Kura, Y; Sawada, U; Yokose, N; Yoshino, A | 1 |
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| Allaart, CF; Bijkerk, C; de Buck, MP; de Sonnaville, PB; Goekoop, RJ; Grillet, BA; Harbers, JB; Heimans, L; Huizinga, TW; Speyer, I; van Oosterhout, M; Visser, K; Wevers-de Boer, KV | 1 |
| Inoue, E; Kobashigawa, T; Momohara, S; Nakajima, A; Tanaka, E; Taniguchi, A; Yamanaka, H | 1 |
| Bombardier, C; Katchamart, W; Ortiz, Z; Rader, T; Shea, B; Swinden, MV; Tanjong Ghogomu, E; Tugwell, P; Wells, GA | 1 |
| Burls, A; Lethaby, A; Lopez-Olivo, MA; Maxwell, L; Tugwell, P; Wells, GA | 1 |
| Cox, VL; de Achaval, S; Garcia-Gonzalez, A; Marengo, MF; Reveille, JD; Richardson, MN; Suarez-Almazor, ME; Waimann, CA | 1 |
| Brown, JC; Chang, DJ; Chu, M; Craigen, J; Kurrasch, R; Overend, P; Patel, B; Wolfe, S | 1 |
| Aguilar-Lozano, L; Castillo-Ortiz, JD; Hernandez-Cuevas, C; Morales-Torres, J; Padilla-Ibarra, J; Ramos-Remus, C; Sanchez-Ortiz, A; Sandoval-Castro, C; Vargas-Serafin, C | 1 |
| Monobe, Y; Ochi, N; Takigawa, N; Yamagishi, T; Yamane, H | 1 |
| Abásolo, L; Fernández-Gutierrez, B; Fontsere, O; Jover-Jover, JA; León, L; Peña-Blanco, RC; Rodriguez-Rodriguez, L | 1 |
| Donmez, S; Keystone, EC; Kisacik, B; Onat, AM; Pamuk, GE; Pamuk, ON; Pehlivan, Y; Sayarlioglu, M | 1 |
| Kameda, H; Kaneko, Y; Kuwana, M; Nishina, N; Takeuchi, T | 1 |
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| Ahluwalia, V; Anis, AH; Brophy, M; Cannella, AC; Keystone, E; Kunkel, G; Leatherman, S; Lew, RA; Mikuls, TR; O'Dell, JR; Phibbs, CS; Taylor, TH; Warren, SR | 1 |
| Masuko, K; Matsui, T; Tohma, S | 1 |
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| Bratt, J; Eriksson, JK; Ernestam, S; Geborek, P; Neovius, M; Petersson, IF; van Vollenhoven, RF | 1 |
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| Fitzpatrick, R; Keary, I; Scott, DG | 1 |
| Bisseling, TM; Cuperus, FJ; Oosterwijk, PR; Remijn, JA; van Dobbenburgh, A; Vos, A | 1 |
| Blanchart, K; Chantepie, S; Charbonneau, P; Du Cheyron, D; Galateau-Salle, F; Paciencia, M; Seguin, A; Terzi, N | 1 |
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| Amante, E; Churchill, M; Doyle, MK; Durez, P; Emery, P; Fleischmann, RM; Hsia, EC; Nash, P; Park, W; Pons-Estel, B; Strusberg, I; Wu, Z; Xu, S; Xu, W | 1 |
| Abdi-Ali, L; Baiardi, P; Benucci, M; Bucci, M; Campostrini, L; Cirino, G; Manfredi, M; Sacco, S; Saviola, G | 1 |
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| Allaart, CF; Giltay, EJ; Heimans, L; Huizinga, TW; Ronday, HK; Steup-Beekman, GM; van der Mast, RC; van Oosterhout, M; Visser, K; Wevers-de Boer, KV | 1 |
| Bandagi, S; Brennessel, D; Dascalu, C; Valceanu, A | 1 |
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| Chen, L; Curtis, JR; Graham, DJ; Griffin, MR; Harrold, LR; Herrinton, LJ; Kowal, MK; Kuriya, B; Lewis, JD; Lii, J; Liu, L; Rassen, JA; Saag, KG; Solomon, DH | 1 |
| Assaraf, YG; Blits, M; Jansen, G; Lems, WF; Nurmohamed, MT; van de Wiel, MA; van Schaardenburg, D; Verweij, CL; Voskuyl, AE; Vosslamber, S; Wolbink, GJ | 1 |
| Chatzidionysiou, K; van Vollenhoven, RF | 2 |
| Doyle, MK; Hsia, EC; Kay, J; Landewé, R; Matteson, EL; Smolen, JS; Xu, S; Zhou, Y | 1 |
| Kay, J; Smolen, JS | 1 |
| Atzeni, F; Benucci, M; Boiardi, L; Sallì, S; Sarzi-Puttini, P | 1 |
| Li, G; Li, L; Li, Y; Yu, C | 1 |
| Husney, R; Privman, V; Sepkowitz, D | 1 |
| Baker, DG; Baker, JF; Conaghan, PG; Emery, P; Hsia, EC; Lu, J; Ostergaard, M | 1 |
| Tao, QW; Wang, JM; Xu, Y; Yan, XP; Zhang, YZ | 1 |
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| Bernatsky, S; Clarke, AE; Kuriya, B; Pineau, CA; Vinet, É | 1 |
| Harigai, M; Hirose, T; Inokuma, S; Ishiguro, N; Koike, T; Ryu, J; Suzukawa, M; Takeuchi, T; Tanaka, Y; Yamanaka, H; Yoshinaga, T | 1 |
| Emery, P; Huizinga, TW; Sebba, A | 1 |
| Combe, B; Keystone, E; Landewé, R; Mease, P; Shaughnessy, L; Strand, V; van der Heijde, D; van Vollenhoven, R; VanLunen, B | 1 |
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| Buchbinder, R; Ciciriello, S; Osborne, RH; Wicks, IP | 1 |
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| Haraoui, B; Keystone, EC; Pope, JE; Poulin-Costello, M; Thorne, JC; Vieira, A | 1 |
| Andersen, LS; Christensen, AF; Ellingsen, T; Hansen, I; Hetland, ML; Hørslev-Petersen, K; Jacobsen, S; Junker, P; Jurik, AG; Lauridsen, UB; Lindegaard, H; Lottenburger, T; Møller, BK; Pedersen, JK; Skjødt, H; Stengaard-Pedersen, K; Svendsen, A; Tarp, U; Thorsen, J; Vestergaard, A; Østergaard, M | 1 |
| Azad, AK; Bari, N; Barua, R; Haq, SA; Hasan, MM; Islam, MA; Islam, MN; Islam, MS; Mahmood, M; Osmany, MF; Rahman, MM; Rashid, FB; Rumki, RS; Safiuddin, M | 1 |
| Assaraf, YG; Dijkmans, BA; Gerards, AH; Jansen, G; Lems, WF; Oerlemans, R; Scheper, RJ; van der Heijden, JW | 1 |
| Boissinot, M; Burska, A; Conaghan, PG; El Jawhari, J; El-Sherbiny, Y; Emery, P; Goëb, V; Harrison, S; Hensor, E; Parmar, R; Ponchel, F; Vital, EM | 1 |
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| Hoekstra, M; Steunebrink, LM; ten Klooster, PM; van de Laar, MA; van Riel, PL; Vonkeman, HE | 1 |
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| Nikitin, AV; Starodubtseva, IA; Vasilieva, LV | 2 |
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| Bowes, MA; Bradley, JD; Conaghan, PG; Fuerst, T; Hrycaj, P; Irazoque-Palazuelos, F; Soma, K; Soto-Raices, O; van der Heijde, D; Wilkinson, B; Wu, C; Wyman, BT; Xie, Z; Zhang, R; Østergaard, M | 1 |
| Eriksson, JK; Ernestam, S; Miller, H; Neovius, M; Petersson, IF; van Vollenhoven, RF; Vivar, N; Wallman, JK | 1 |
| Bridges, SL; Cofield, S; Curtis, JR; Jalal, H; Michaud, K; Mikuls, TR; Moreland, LW; O'Dell, JR | 1 |
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| Fukuda, T; Harada, H; Haraguchi, A; Inoue, Y; Ishinishi, T; Iwamoto, Y; Kondo, M; Maekawa, M; Maeyama, A; Miyahara, H; Nakashima, M; Nakashima, Y; Shimauchi, T; Shono, E; Suematsu, E; Tsukamoto, H; Tsuru, T; Yoshizawa, S | 1 |
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| Brown, AK; Conaghan, PG; Emery, P; Freeston, J; Hensor, E; Karim, Z; Keen, H; Nizam, S; Quinn, M; Saleem, B; Wakefield, R | 1 |
| Bao, CD; Chen, ZW; Dai, M; Du, F; Fan, W; Gu, JR; Han, XH; He, PG; Li, JH; Li, XF; Lu, LJ; Tao, Y; Teng, JL; Wu, HX; Xu, JH; Yang, NP; Yu, H; Zhang, MJ; Zhao, YH | 1 |
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| Douglas, KM; John, H; Kitas, GD; Panoulas, VF; Toms, TE | 1 |
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| Abe, T; Inoue, K; Koike, T; Miyasaka, N; Takeuchi, T | 1 |
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| Barclay, ML; Chapman, PT; Frampton, C; James, J; O'Donnell, JL; Stamp, LK; Zhang, M | 2 |
| Bartelds, GM; Crusius, JB; de Vries, N; Dijkmans, BA; Nurmohamed, MT; Tak, PP; van der Horst-Bruinsma, IE; Wijbrandts, CA; Wolbink, GJ | 1 |
| Hashiguchi, M; Inoue, S; Kawai, S; Mochizuki, M | 1 |
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| Kageyama, Y; Kato, N; Kobayashi, H | 1 |
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| Dijkmans, BA; Horikx, A; van den Bemt, BJ; van der Waal, RI; Verduijn, MM | 2 |
| Aoyagi, K; Aramaki, T; Arima, K; Eguchi, K; Fujikawa, K; Furuyama, M; Ida, H; Iwamoto, N; Kamachi, M; Kawakami, A; Kawashiri, SY; Matsuoka, N; Mizokami, A; Nakamura, H; Nakashima, M; Origuchi, T; Tamai, M; Ueki, Y; Yamasaki, S | 1 |
| Borea, PA; Massara, A; Padovan, M; Tosi, A; Trotta, F; Varani, K; Vincenzi, F | 1 |
| Amjadi, S; Charles-Schoeman, C; Elashoff, D; Fogelman, AM; Furst, DE; Lee, YY; McMahon, M; Park, G; Paulus, HE; Reddy, ST; Watanabe, J | 1 |
| Dijkmans, BA; Nurmohamed, MT; Raterman, HG; Voskuyl, AE | 1 |
| Chapman, PT; Frampton, C; James, J; O'Donnell, JL; Stamp, LK; White, DH | 1 |
| Aletaha, D; Baker, D; Funovits, J; Köller, MD; Pangan, A; Smolen, JS | 1 |
| de Thurah, A; Harder, I; Nørgaard, M; Stengaard-Pedersen, K | 1 |
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| den Hollander, JG; Hendriks, WD; Slingerland, R; Swart, RM; van Ingen, J; van Soolingen, D | 1 |
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| Greenberg, J; Kremer, JM | 1 |
| Emery, P; Kavanaugh, A; Keystone, E; Purcaru, O; Richard, L; Smolen, JS; Strand, V; van Vollenhoven, RF | 1 |
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| Douglas, KM; Gasparyan, AY; Kitas, GD; Stavropoulos-Kalinoglou, A; Toms, TE | 1 |
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| Burmester, GR; Combe, B; Coteur, G; Kavanaugh, A; Keystone, EC; Mease, P; Nikaï, E; Strand, V; van Vollenhoven, R | 1 |
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| Bao, CD; Li, XF; Liu, HX; Liu, S; Ni, LQ; Shen, J; Sun, BL; Sun, LY; Wang, RC; Wei, W; Wu, YQ; Xiao, F; Xu, JH; Xu, SQ; Zhang, LL; Zhang, RH; Zhang, W | 1 |
| Ai, MX; Bao, CD; Fang, YF; Gu, JR; He, DY; Huang, CB; Huang, F; Li, ZG; Lu, J; Shi, Q; Sun, LY; Tao, Y; Wu, DH; Wu, HX; Xu, HJ; Yang, NP; Yang, XY; Ye, ZZ; Zhang, FC; Zhang, MJ; Zhang, W; Zhang, X; Zhao, DB; Zheng, Y; Zhu, P | 1 |
| Liu, XD; Ye, LH; Zhang, JL | 1 |
| Collard, HR; Elicker, BM; Kim, EJ; King, TE; Lee, JS; Maldonado, F; Ryu, JH; Van Uden, JH; Webb, WR | 1 |
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| Burmester, GR; Grützkau, A; Häupl, T; Hernandez, MM; Kinne, RW; Kuban, RJ; Salfeld, J; Stuhlmüller, B; Tandon, N; Voss, JW | 1 |
| Benne, CA; Bijl, M; Blom, M; de Haan, A; Holvast, A; Kallenberg, CG; Posthumus, MD; Risselada, AP; van Assen, S; van Leeuwen, MA; Voskuyl, AE; Westra, J | 1 |
| Agarwal, S; Bingham, CO; Codding, C; Deodhar, A; Greenwald, M; Halsey, N; Kelman, A; Looney, RJ; Martin, F; Trzaskoma, B | 1 |
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| Chen, YQ; Chen, ZW; Li, YM; Sun, J | 1 |
| de Thurah, A; Johansen, MB; Nørgaard, M; Stengaard-Pedersen, K | 1 |
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| Boers, M; Buttgereit, F; Dijkmans, BA; Houbiers, JG; In 't Hout, J; Kvien, TK; Leij, S; Miltenburg, AM; Sierakowski, S; Szczepański, L; Szombati, I; van Vollenhoven, RF | 1 |
| Bauer, AS; Blazar, PE; Earp, BE; Simmons, BP | 1 |
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| He, Y; Jiang, M; Lu, A; Zha, Q; Zhao, J | 1 |
| de Thurah, A; Johansen, M; Nørgaard, M; Stengaard-Pedersen, K | 1 |
| Allaart, CF; Guchelaar, HJ; Huizinga, TW; Kooloos, WM; van der Straaten, T; Wessels, JA | 1 |
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| Abgueguen, P; Delori, M; Fanello, S; Houitte, R; Jousset, Y; Tanguy, M | 1 |
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| D'Amelio, R; Ferlito, C; Germano, V; Laganà, B; Migliore, A; Picchianti-Diamanti, A | 1 |
| Bartegi, A; Ben Amor, N; Bouaziz, A; Mnif, W; Zidi, I | 1 |
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| Abrahamyan, L; Beyene, J; Chon, Y; Feldman, BM; Feng, J; Horneff, G; Keystone, EC; Schmeling, H; Willan, AR | 1 |
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| Andersen, LS; Ejbjerg, BJ; Ellingsen, T; Hansen, I; Hetland, ML; Hørslev-Petersen, K; Jacobsen, S; Junker, P; Jurik, AG; Lauridsen, UB; Lindegaard, H; Lottenburger, T; Pedersen, JK; Pødenphant, J; Stengaard-Pedersen, K; Svendsen, A; Tarp, U; Vestergaard, A; Østergaard, M | 1 |
| Falconer, J; Isaacs, JD; Ng, WF; Pratt, A; Tudhope, SJ; von Delwig, A; Wilson, G; Woolridge, T | 1 |
| Dougados, M; Gaujoux-Viala, C; Gossec, L; Kvien, TK; Landewé, R; Mola, EM; Scholte-Voshaar, M; Smolen, JS; van Riel, P | 1 |
| Buch, MH; Emery, P; Hensor, EM; Landewé, R; Nam, JL; Pavelka, K; Smolen, JS; Valesini, G; van Vollenhoven, RF; Winthrop, KL; Worthy, G | 1 |
| Anofrei, A; Baumgartner, S; Calabrese, L; Curtis, JR; Furst, DE; Greenberg, JD; Hooper, M; Kavanaugh, A; Kremer, JM; Reed, G; Sokolove, J; Strand, V | 1 |
| Aliko, A; Alushi, A; Ciancaglini, R; Tafaj, A | 1 |
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| Jacobs, AM | 1 |
| Choe, JY; Kim, SK; Park, SH | 1 |
| Allaart, CF; de Vries-Bouwstra, JK; Dijkmans, BA; Goekoop-Ruiterman, YP; Huizinga, TJ; Huizinga, TW; Hulsmans, HM; Kerstens, PJ; Klarenbeek, NB; Speyer, I; van der Kooij, SM; van Krugten, MV | 1 |
| Hammer, HB; Kongtorp, AK; Kvien, TK; Sveinsson, M | 1 |
| Darmochwal-Kolarz, D; Dryglewska, M; Kolarz, B; Majdan, M | 1 |
| Jakez-Ocampo, J; Llorente, L; Paulìn-Vera, CM | 1 |
| Falgarone, G; Legré, V; Lioté, F; Lizard, G; Maillefert, JF; Maynadié, M; Morel, J; Ornetti, P; Puéchal, X; Sibilia, J; Solau, E | 1 |
| Harada, H; Horiuchi, T; Ishinishi, T; Iwamoto, Y; Jojima, H; Kondo, M; Kuroda, K; Miyahara, H; Nagamine, R; Nakashima, H; Nakashima, Y; Otsuka, T; Saikawa, I; Shono, E; Suematsu, E; Tsuru, T; Wada, K | 1 |
| Allaart, CF; de Vries-Bouwstra, JK; Dijkmans, BA; Gerards, AH; Goekoop-Ruiterman, YP; Güler-Yüksel, M; Huizinga, TW; Klarenbeek, NB; Lems, WF; Ronday, HK; van der Kooij, SM | 1 |
| Kanelleas, A; Katoulis, AC; Panayiotides, I; Stavrianeas, NG; Zambacos, G | 1 |
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| Booth-Laforce, C; Furst, DE; Krishna Kumar, PR; Krishna Swamy, BG; Mahapatra, A; McGann, M; Ram Manohar, P; Sarin, R; Venkatraman, MM | 1 |
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| Bhagat, SS; Campbell, L; Chen, C; Östör, AJ; Parker, RA | 1 |
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| Hameed, K; Ishaq, M; Mirza, AI; Muhammad, JS | 1 |
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| Atsumi, T; Fujii, T; Harigai, M; Ihata, A; Ito, S; Kawakami, A; Koike, R; Komano, Y; Miyasaka, N; Nakajima, A; Nanki, T; Saito, K; Sakai, R; Sugihara, T; Tamura, N; Tanaka, M; Tanaka, Y; Tohma, S; Yasuda, S | 1 |
| Ashcroft, DM; Hyrich, KL; Lunt, M; Soliman, MM; Symmons, DP; Watson, KD | 1 |
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| Elden, A; Haugeberg, G; Hoff, M; Kälvesten, J; Kavanaugh, A; Kvien, TK | 1 |
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| Burmester, GR; Coteur, G; Hiepe, F; Khanna, D; Mease, P; Nikaï, E; Schiff, M; Smolen, JS; Strand, V; van Vollenhoven, RF | 1 |
| Allaart, CF; Dijkmans, BA; Güler-Yüksel, M; Han, KH; Huizinga, TW; Kerstens, PJ; Klarenbeek, NB; Ronday, HK; Seys, PE; van der Kooij, SM | 1 |
| Inoue, E; Momohara, S; Nakajima, A; Seto, Y; Tanaka, E; Taniguchi, A; Yamanaka, H | 1 |
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| Farajzadegan, Z; Salesi, M | 1 |
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| Crowson, CS; Davis, JM; Gabriel, SE; Maradit-Kremers, H; Myasoedova, E; Nicola, PJ; Roger, VL; Therneau, TM | 1 |
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| Al-Husain, A; Bruce, IN; Mirjafari, H | 1 |
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| Boltuch-Sherif, J; Erlacher, L; Horvath-Mechtler, B; Kowalski-Bodzenta, J; Mustak, M | 1 |
| Ideguchi, H; Ishigatsubo, Y; Nozaki, A; Ohno, S; Takase, K; Watanabe, K | 1 |
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| Cannon, GW; Caplan, L; Curtis, JR; Hayden, CL; Johnson, DS; Kerr, GS; Mikuls, TR; Reimold, AM; Richards, JS; Sauer, BC; Ying, J | 1 |
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| Chen, Q; Hobo, K; Kanbe, K; Nakamura, A | 1 |
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| Curtis, JR; Emery, P; Gaylis, NB; Mease, PJ; Müller-Ladner, U; Reynard, M; Rubbert-Roth, A; Tyrrell, H; Williams, S | 1 |
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| Balak, W; Banach, J; Bujak, R; Błażejewski, J; Jeka, S; Karasek, D; Sinkiewicz, A; Sinkiewicz, W | 1 |
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| Gravallese, EM; Walsh, NC | 1 |
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| Bruce, B; Fries, JF; Krishnan, E; Lingala, B | 1 |
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| de Jonge, R; den Boer, E; Lindemans, J; Luider, TM; Meesters, RJ | 1 |
| Jönsson, G; Kapetanovic, MC; Roseman, C; Truedsson, L | 1 |
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| Chatzidionysiou, K; Gabay, C; Gomez-Reino, J; Hetland, ML; Kvien, TK; Lie, E; Lukina, G; Nasonov, E; Nordström, DC; Pavelka, K; Tarp, U; Tomsic, M; van Riel, PL; van Vollenhoven, RF | 1 |
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| Bitman, B; Chen, L; Curtis, JR; Kavanaugh, A; Navarro-Millan, I; Park, GS; Wang, B; Yang, S | 1 |
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| Cohen, S; Connell, CA; French, JL; Gomez-Reino, J; Gruben, D; Kanik, KS; Kremer, JM; Krishnaswami, S; Pascual-Ramos, V; Wallenstein, G; Wilkinson, BE; Zwillich, SH | 1 |
| Healy, E; Hessey, E; Peterfy, C; Reynard, M; Rigby, W; Rubbert-Roth, A; Shaw, T; Stohl, W; Tak, PP; van Vollenhoven, RF | 1 |
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| Aguilar, D; Alpizar-Rodríguez, D; Cruz-Robles, D; Escobar-Hernández, S; Férez-Blando, K; Furuzawa-Carballeda, J; Galindo-Feria, AS; Llorente, L; Macip-Rodríguez, P; Soto-Abraham, V | 1 |
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| Dervieux, T; Guchelaar, HJ; Huizinga, TW; Klareskog, L; Kremer, JM; Padyukov, L; Saevarsdottir, S; Seddighzadeh, M; van Vollenhoven, RF; Wessels, JA | 1 |
| Chen, N; Cifaldi, MA; Rentz, AM; Revicki, D; Roy, S; Strand, V | 1 |
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| Alcalá Díaz, JF; Fernández de la Puebla, RÁ; García Olid, B; Guirao Arrabal, E | 1 |
| Farkouh, ME; Furer, V; Greenberg, JD | 1 |
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| Baker, D; Kim, L; Kremer, J; Mack, M; Mendelsohn, A; Ritchlin, C; Taylor, PC; Xu, Z | 1 |
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| Hamada, A; Kato, T; Mori, S; Saito, H | 1 |
| Baker, D; Harigai, M; Ishiguro, N; Kanazawa, M; Koike, T; Miyasaka, N; Oba, T; Takeuchi, T; Tanaka, Y; Yamamoto, K; Yamanaka, H; Yoshinari, T | 1 |
| Aletaha, D; Avila, JC; Smolen, JS | 1 |
| Arbogast, PG; Chen, L; Curtis, JR; Delzell, E; Griffin, MR; Grijalva, CG; Herrinton, L; Kawai, VK; Liu, L; Mitchel, EF; Ouellet-Hellstrom, R; Solomon, DH; Stein, CM | 1 |
| García-Buey, L; García-Sanchez, A; Moreno-Otero, R; Trapero-Marugán, M | 1 |
| Kaneko, A; Kida, D; Saito, K; Sato, T; Tsukamoto, M | 1 |
| Abbed, K; Combe, B; Dougados, M; Hendel-Chavez, H; Le Loët, X; Mariette, X; Rouanet, S; Sellam, J; Sibilia, J; Taoufik, Y; Tebib, J | 1 |
| Conaghan, PG; Emery, P; Fleischmann, R; Hsia, EC; Rahman, MU; Xu, W; Østergaard, M | 1 |
| Bakker, MF; Bijlsma, JW; Jacobs, JW; Kruize, AA; Lafeber, FP; van Booma-Frankfort, C; van der Veen, MJ; Vreugdenhil, SA; Welsing, PM | 1 |
| Damjanov, NS; Kovacevic, LV; Pejnovic, NN; Sefik-Bukilica, MN; Soldatovic, II; Zivojinovic, SM | 1 |
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| Symmons, DP; Verstappen, SM | 1 |
| Bijlsma, JW; Jacobs, JW; Jurgens, MS | 1 |
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| Ancuta, C; Balanescu, A; Cardarelli, PM; Chirieac, R; Leblanc, H; Luo, A; Nichol, G; Paliienko, I; Tao, X; Ter-Vartanian, S; Tseluyko, V; Xu, LA; Yellin, M | 1 |
| Bergman, G; Christensen, R; Drost, P; Guyot, P; Lebmeier, M; Pericleous, L; Poncet, C; Taylor, P | 1 |
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| Boers, M; Dijkmans, BA; Nielen, MM; Tijhuis, GJ; van der Horst-Bruinsma, I; van Eijk, IC; van Schaardenburg, D | 1 |
| Davis, HM; de Vries, DE; Doyle, MK; Ford, JA; Frederick, B; Keen, M; Petty, KJ; Xu, Z; Zhou, H; Zhuang, Y | 1 |
| Bakker, A; Boumans, MJ; de Boer, M; Gerlag, DM; Jacobson, EW; Krausz, S; Lodde, BM; Lufkin, J; O'Meara, M; Reedquist, KA; Tak, PP; van Kuijk, AW | 1 |
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| Anastasopoulou, AN; Karagiannidis, GS; Mantzourani, M; Meletis, J; Vaiopoulos, GA | 1 |
| Den Broeder, AA; Fransen, J; Haagsma, CJ; Hoekstra, MO; Kuper, HH; Schipper, LG; van de Laar, MA; van Riel, P; Vermeer, M | 1 |
| Hart, C; Kinney, MO; McCarron, MO | 1 |
| Charles, CJ; Cooper, DL; Emery, P; Isaacs, JD; Mackie, SL; Martin, SG; Morgan, AW; Nam, J; Robinson, JI | 1 |
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| Bombonato-Prado, KF; Cunha, FQ; Cunha, TM; Donadi, EA; Donate, PB; Ferreira, SH; Junta, CM; Lima, FO; Louzada, P; Passos, GA; Peres, RS; Verri, WA; Vieira, SM | 1 |
| Abe, H; Sato, Y | 1 |
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| Kageyama, M; Kempe, K; Kon, T; Kusaoi, M; Matsudaira, R; Matsushita, M; Ogasawara, M; Onuma, S; Sekiya, F; Sugimoto, K; Tada, K; Takasaki, Y; Tamura, N; Yamaji, K | 1 |
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| Batliwalla, F; Coblyn, JS; Cui, J; Ercan, A; Gregersen, P; Hazen, MM; Lee, DM; Nigrovic, PA; Royle, L; Rudd, PM; Shadick, N; Weinblatt, ME | 1 |
| Bakker, MF; Bijlsma, JW; Geurts, MA; Jacobs, JW; Jahangier-de Veen, ZN; Lafeber, FP; Tekstra, J; Ton, E; van Albada-Kuipers, GA; van der Veen, MJ; van der Werf, JH; Verhoef, CM; Verstappen, SM; Welsing, PM | 1 |
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| Fujibayashi, T; Fukaya, N; Funahashi, K; Hanabayashi, M; Hattori, Y; Hayashi, M; Hirabara, S; Hirano, Y; Ishiguro, N; Ishikawa, H; Kaneko, A; Kato, D; Kato, T; Kida, D; Kojima, T; Matsubara, H; Miyake, H; Oguchi, T; Takagi, H; Takahashi, N; Terabe, K; Tsuboi, S; Yabe, Y; Yoshioka, Y | 1 |
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| Asai, N; Funahashi, K; Hattori, Y; Hayashi, M; Hirano, Y; Ishiguro, N; Ishikawa, H; Kaneko, A; Kato, D; Kato, T; Kida, D; Kojima, T; Matsubara, H; Miyake, H; Shioura, T; Takagi, H; Takahashi, N; Terabe, K; Tsuchiya, H; Wanatabe, T; Yabe, Y | 1 |
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| Baecklund, E; Bresnihan, B; Cazzato, M; Gogus, F; Gossec, L; Herborn, G; Kautiainen, H; Lund Hetland, M; Mäkinen, H; McClinton, C; Naranjo, A; Pincus, T; Rau, R; Sierakowski, S; Skakic, V; Sokka, T; Taylor, P; Toloza, S; Verstappen, SM | 1 |
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| Davis, CS; Dayton, CS; Furst, DE; Hunninghake, GW; Koehnke, RK; Schwartz, DA; Sprince, NL; Yagla, SJ | 1 |
| Boerbooms, AM; Jeurissen, ME; Kerstens, PJ; Mulder, J; van de Putte, LB; Van Erp, A; Westgeest, TA | 1 |
| Bijlsma, JW; Jacobs, JW; Schenk, Y; van der Heide, A | 1 |
| Boerbooms, AM; De Graaf, TW; Kerstens, PJ; Van der Stelt, ME; Van Dijk, W; Van Ommen, EC | 1 |
| Hamilton, RA; Kremer, JM; Petrillo, GF | 2 |
| Dunne, CA; Moran, CJ; Mounce, KE | 1 |
| Capell, HA; Crilly, A; Madhok, R; McDonald, AG; McInness, IB; Watson, J | 1 |
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| Davies, JM; Fink, S; Kremer, JM; Lawrence, DA; Mullaly, PM; Petrillo, GF; Rynes, RI | 1 |
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| Bos, JD; Zonneveld, IM | 1 |
| Megyeri, A; Merétey, K; Schmidt, Z; Szilágyi, M | 1 |
| Fischman, A; Palmer, WE; Polisson, RP; Rosenthal, D; Rubin, R; Schoenberg, OI; Simon, LS | 1 |
| Bartoli, E; Boiocchi, M; Carbone, A; Casatta, L; De Vita, S; Dolcetti, R; Ferraccioli, GF | 1 |
| Alarcón, GS; Moreland, L; Morgan, SL | 1 |
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| Ahern, MJ; Chandran, G; Geddes, R; Hall, PD; Harley, JH; Hill, W; Smith, MD | 1 |
| Hammoudeh, M; Khanjar, I; Siam, AR | 1 |
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| Barrera, P; Boerbooms, AM; Dekhuijzen, PN; Laan, RF; van de Putte, LB; van Riel, PL | 1 |
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| Anderson, L; Block, S; Gall, E; Germain, BF; Kaplan, H; Merriman, RC; Solomon, SD; Wall, B; Weinblatt, ME; Wolfe, F | 1 |
| Grant-Kels, JM; Grin-Jorgensen, C; Petrazzuoli, M; Ramsey, WH; Rothe, MJ | 1 |
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| Franck, H; Herborn, G; Ittel, TH; Rau, R; Tasch, O | 1 |
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| Alarcón, GS; Austin, JS; Baggott, JE; Koopman, WJ; Krumdieck, CL; Lee, JY; Morgan, SL; Vaughn, WH; Veitch, TA | 1 |
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| de Rooij, DJ; Haagsma, CJ; Russel, FJ; van de Putte, LB; van Riel, PL; van't Hof, MA; Vree, TB | 1 |
| Leidner, B | 1 |
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| Fries, JF; Ramey, DR; Singh, G | 1 |
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| Morris, AJ; Morris, CR | 1 |
| Goodman, TA; Polisson, RP | 1 |
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| Halberg, P | 1 |
| Cantabrana, A; Dávila, M; Hayek, M; Roces, A | 1 |
| Dorfman, RF; Kamel, OW; LeBrun, DP; van de Rijn, M; Warnke, RA; Weiss, LM | 1 |
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| Casey, E; Clancy, L; Hartley, P; Jeffers, M; O'Reilly, S | 1 |
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| Sigidin, IaA; Usova, SB | 1 |
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| Longmire, AW; Minton, TA; Morrow, JD; Pincus, T; Roberts, LJ; Stein, CM | 1 |
| Bradley, JD; Brater, DC; Greene, PK; Tracy, TS; Worster, T | 1 |
| Bannwarth, B; Dehais, J; Marcé, S; Schaeverbeke, T | 1 |
| Sweetman, BJ | 1 |
| López Martín, JC; Martínez Estéfano, E; Moreno Garrido, D; Torre Sabariego, A | 1 |
| Goulet, JR; Haraoui, B; Martel-Pelletier, J; Ouellet, M; Pelletier, JP; Raynauld, JP; Thonar, EJ | 1 |
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| Descamps, JM; Kuteifan, K; Martin-Barbaz, F; Sechet, A | 1 |
| Boerbooms, AM; Brummelkamp, EP; Kerstens, PJ; Van de Putte, LB | 1 |
| Shiroky, J | 1 |
| van 't Hof, M; van de Putte, LB; van der Heijde, DM; van Riel, PL | 1 |
| Calin, A; Lovell, C; O'Neill, T; Simpson, J; Smyth, SJ | 1 |
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| Braun, O; Kolarz, G; Popp, W; Ritschka, L; Scherak, O; Wottawa, A | 1 |
| Clemmey, P; Culbertson, AL; Lewis, C; Nicassio, PM; Radojevic, V; Weisman, MH | 1 |
| Callahan, LF; Pincus, T | 1 |
| Bruyn, GA; Eggink, HF; Houtman, PM; Pasma, HR; Stenger, AA | 1 |
| Bijlsma, JW; van der Veen, MJ | 1 |
| Bolla, G; Disdier, P; Harle, JR; Verrot, D; Weiller, PJ | 1 |
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| Boyle, DL; Firestein, GS; Paine, MM | 1 |
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| Delclaux, B; Derenne, JP; Whitelaw, WA | 1 |
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| Fuchs, HA; Pincus, T | 1 |
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| Blotman, F; Hellier, JP; Leroux, JL; Thomas, E | 1 |
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| Kuhn, M; Luzi, HP; Reinhart, WH; Wyss, E | 1 |
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| Chassany, O; Chevalier, X; Claudepierre, P; Larget-Piet, B; Tillement, JP; Urien, S | 1 |
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| Müller-Suur, R; Seideman, P | 1 |
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| Carroll, GJ; Thomas, R | 1 |
| De Vuyst, P; Gevenois, PA; Jacobovitz, D; Leduc, D; Lheureux, P; Yernault, JC | 1 |
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| Anaya, JM; Combe, B; Didry, C; Gutierrez, M; Sany, J | 1 |
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| Tariq, S; Tariq, SM | 1 |
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| Armas, R; Carvallo, A; Domic, H; Donoso, G; Lobo, G; Náquira, N; Rojas, C; Villanueva, P; Wolff, C | 1 |
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| Bruyn, GA; Essed, CE; Houtman, PM; Willemse, FW | 1 |
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| Alarcón, GS; Krumdieck, CL; Morgan, Sl | 1 |
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| al-Awadhi, A; Dale, P; McKendry, RJ | 1 |
| Ekman, E; Müller-Suur, R; Seideman, P | 1 |
| Anaya, JM; Canovas, F; Combe, B; Gavroy, JP; Jorgensen, C; Saker, S; Sany, J; Thaury, MN | 1 |
| Peron, JM; Pointud, P; Prudat, M | 1 |
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| Miller-Blair, DJ; Robbins, DL | 1 |
| Barrera, P; Boerbooms, AM; de Boo, T; Demacker, PN; Gallati, H; Janssen, EM; Mulder, J; Sauerwein, RW; van de Putte, LB; van der Meer, JW | 1 |
| Weber, MH | 1 |
| Alarcón, GS; Koopman, WJ; McCarty, MJ | 1 |
| Dean, HA; Minocha, A; Pittsley, RA | 1 |
| Cobeta-Garcia, JC; Fontova-Garrofé, R; Ruiz-Jimeno, MT | 1 |
| Brown, A; Hine, RJ; Morgan, SL; Vaughn, WH | 1 |
| Bloch, DA; Fries, JF; Ramey, D; Williams, CA | 1 |
| Alarcón, GS; Dreyer, NA; Funch, D; Kremer, JM; Lee, RG; Tolman, KG; Walker, AM; Weinblatt, ME | 1 |
| Trentham, DE | 2 |
| Hasler, F | 1 |
| Castanet, J; Dujardin, P; Ferrari, E; Garnier, G; Pesce, A; Taillan, B | 1 |
| Mashiah, V; Meyer, FA; Yaron, I; Yaron, M | 1 |
| Acquaviva, PC; Catalin, J; Durand, A; Lafforgue, P; Monjanel-Mouterde, S | 2 |
| Beck, O; Eksborg, S; Seideman, P; Wennberg, M | 1 |
| Aliabadi, P; Baker, N; Blotner, SD; Polisson, R; Sosman, JL; Weinblatt, ME; Weissman, BN | 1 |
| Spencer-Green, G | 1 |
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| Akizuki, M; Mukai, M; Watanabe, F; Yoshida, T | 1 |
| Carpenter, M; Hassan, W; Kelly, C | 1 |
| Pullar, T; Veale, D | 1 |
| Buchbinder, R; Champion, GD; Hall, S; Harkness, A; Lewis, D; Littlejohn, GO; Miller, MH; Ryan, PF; Sambrook, PN | 1 |
| Anaya, JM; Combe, B; Guttierrez, M; Sany, J | 1 |
| Herborn, G; Rau, R; Wassenberg, S | 2 |
| Alarcón, GS; Sullivan, WF | 1 |
| Bykerk, V; Choquette, D; Esdaile, JM; Hazeltine, M; Kanji, M; Neville, C; Robidoux, L; Shiroky, JB; St-Pierre, A; Zummer, M | 1 |
| Pincus, T; Stein, CM | 1 |
| Grassanovich, JL; Harman, JG; Klein, JP; McCarty, DJ; Qian, C | 1 |
| Bijlsma, JW; Dekker, JJ; Dinant, HJ; van der Veen, MJ; van Soesbergen, RM | 1 |
| Hauwaert, C; Kaye, O; Malaise, MG; Ribbens, C | 1 |
| Haagsma, CJ; van de Putte, LB; van Riel, PL | 1 |
| Alarcón, GS; Morgan, SL; Sandoval, DM | 1 |
| Kolarz, G; Mayrhofer, F; Peichl, P; Posch, E; Scherak, O; Singer, F; Thumb, N; Wottawa, A | 1 |
| Klama, K; Lacki, JK; Mackiewicz, SH; Müller, W; Schochat, T | 1 |
| Ichikawa, Y; Noguchi, A; Yamada, H | 1 |
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| Bergoend, H; Cardon, T; Catteau, B; Delaporte, E; Delcambre, B; Flipo, RM; Lecomte-Houcke, M; Piette, F | 1 |
| Anderson, JJ; Chernoff, MC; Felson, DT; Wang, M | 1 |
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| Criswell, LA; Henke, CJ | 1 |
| Bambara, LM; Biasi, D; Caramaschi, P; Carletto, A | 2 |
| Furst, DE; Gardner, G | 1 |
| Dijkmans, BA | 1 |
| Drymalski, W; Eckhoff, PJ; Erikson, N; Garwood, V; Haire, CE; Klassen, LW; Klein, H; Maloley, P; Moore, GF; O'Dell, JR; Palmer, W; Wees, S | 1 |
| Bijlsma, JW; Damen, CA; Lafeber, FP; Scheven, BA; van der Veen, MJ; van Roy, JL | 1 |
| Bakker, WK; Bos, JD; Dijkstra, PF; Dinant, HJ; van Soesbergen, RM; Zonneveld, IM | 1 |
| Bernard, JP; Cottin, V; Massonnet, B; Souquet, PJ; Tébib, J | 1 |
| Hilliquin, P; Menkès, CJ; Perrot, S; Puéchal, X; Renoux, M | 1 |
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| Armona, J; Blanco, R; Fernández-Sueiro, JL; González-Gay, MA; González-Vela, MC; Martínez-Taboada, VM; Rodríguez-Valverde, V | 1 |
| Cooper, DL; Crouch, J; Howe, G; Lacy, J; Murren, J; Salloum, E; Schultz, M; Tallini, G | 1 |
| Costa, J; Moreno, F; Olive, A; Riba, N | 1 |
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| Anderson, PL; Jensen, MP; Møller, BK; Obel, N; Stengaard-Pedersen, K; Storgaard, M | 1 |
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| Cohen, PR; Hymes, SR; Vine, JE; Warner, NB | 1 |
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| Burchardi, C; Gross, WL; Herlyn, K; Reinhold-Keller, E; Schnabel, A | 1 |
| Bologna, C; Bressolle, F; Combe, B; Edno, L; Gomeni, R; Sany, J | 1 |
| Hakoda, M; Kamatani, N; Kashiwazaki, S; Nakajima, A; Yamanaka, H | 1 |
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| Arkfeld, DG; Stohl, W | 1 |
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| Burchardi, C; Gross, WL; Schnabel, A | 1 |
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| Akizuki, M; Hara, M; Hayashi, T; Ichikawa, Y; Kashiwazaki, S; Kondo, H; Matsuoka, Y; Torikai, K; Uchida, S | 1 |
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| Cevallos, WH; DeCleene, SA; Gumbhir-Shah, K; Korth-Bradley, JM | 1 |
| Usman, AR; Yunus, MB | 1 |
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| Laroche, F; Menkés, CJ; Perrot, S | 2 |
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| Khraishi, MM; Singh, G | 1 |
| Capell, HA; Duncan, MR | 1 |
| Lacki, JK; Mackiewicz, S; Mackiewicz, U; Samborski, W | 1 |
| Appelboom, T; Gangji, V; Golstein, M | 1 |
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| Heathcote, J | 1 |
| Bambara, LM; Biasi, D; Capra, F; Caramaschi, P; Carletto, A; Casaril, M; Corrocher, R | 1 |
| Gertner, E; Marshall, PS | 1 |
| Blotner, SD; Furst, DE; Kremer, JM; Weinblatt, ME | 1 |
| Stablein, D; Willkens, RF | 1 |
| Drymalski, W; Erikson, N; Haire, C; Klassen, LW; Maloley, P; Moore, GF; O'Dell, JR; Palmer, W; Wees, S | 1 |
| Dubin Kerr, L; Isola, L; Troy, K | 1 |
| Carlson, PL; Han, J; Mcgee, B; Moxley, G; Ruddy, S; Singh, R; Small, RE | 1 |
| Hayem, G; Kahn, MF; Meyer, O | 1 |
| Gerster, JC | 1 |
| Massarotti, EM | 1 |
| Georgou, TA; Hunninghake, GW; Koehnke, RK; Kolluri, S; Rachow, JW; Saag, KG; Schwartz, DA | 1 |
| Marks, C; Sharp, JT; Stablein, D; Willkens, RF; Wortmann, R | 1 |
| Bowman, S; Mowat, A | 1 |
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| Cuéllar, ML; Espinoza, LR; García, CO; Gutierrez-Ureña, S; Molina, JF | 1 |
| Bachman, TR; Cannon, GW; Perkins, SL; Sawitzke, AD; Ward, JH | 1 |
| Bernard, JC; Bologna, C; Bressolle, F; Combe, B; Edno, L; Gomeni, R; Sany, J | 1 |
| Haagsma, CJ; Russel, FG; Van de Putte, LB; Van Riel, PL; Vree, TB | 1 |
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| Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ | 1 |
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| Cooley, DA; Goldman, AL; Harshbarger, JL; Huffstutter, JE; Hughes, GM; Isern, RA; Keenan, GF; Quinn, A; Roth, SH; Schaible, TF; Shergy, WJ; Spencer-Smith, EA; Toder, JS; Warner, D | 1 |
| Franzen, P; Gripenberg-Gahmberg, M; Hannonen, P; Helve, T; Ilonen, J; Kaipiainen-Seppänen, O; Kautiainen, H; Korpela, M; Koski, J; Laasonen, L; Leirisalo-Repo, M; Möttönen, T; Myllykangas-Luosujärvi, R; Nissilä, M | 1 |
| Choi, HK; Hernán, MA; Robins, JM; Seeger, JD; Wolfe, F | 1 |
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| Akama, H; Kamatani, N; Kitamura, Y; Saito, M; Saito, T; Tanaka, E; Taniguchi, A; Urano, W; Yamanak, H | 1 |
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| Bradley, JD; Brater, DC; Hall, SD; Jones, DR; Krohn, K; Tracy, TS | 1 |
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| Elhardt, D; Herborn, G; Karger, T; Menninger, H; Rau, R; Schmitt, J | 2 |
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| Bank, I; Gruberg, L; Pras, M; Rozenman, J; Thaler, M | 1 |
| Boerbooms, AM; Doesburg, WH; Haverman, JF; Jeurissen, ME; Kruijsen, MW; Mulder, J; Muller, WH; Rasker, JJ; van Beusekom, HJ; van de Putte, LB | 1 |
| Cathey, MA; Wolfe, F | 2 |
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| Ahern, MJ; Hall, PD; Harley, H; Jarvis, LR; Jenner, MA; Stoll, P | 1 |
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| Hilliquin, P; Laoussadi, S; Menkès, CJ | 1 |
| Ackerman, C; Goemaere, S; Mielants, H; Van der Straeten, C; Veys, EM | 1 |
| Alarcón, GS; Bridges, SL; Han, KH; López-Méndez, A; Tracy, IC | 1 |
| Smallwood, RA; Watson, RG | 1 |
| Mayall, B; Parkin, JD; Poggi, G | 1 |
| Brown, MA; Corrigan, AB | 1 |
| Balabanova, RM; Oliunin, IuA; Seĭsenbaev, ASh; Tupitsin, NN | 1 |
| Bakker, LJ; Bijlsma, JW; Cornelissen, JJ; Rozenberg-Arska, M; Van der Veen, MJ | 1 |
| Herborn, G; Karger, T; Rau, R; Werdier, D | 1 |
| Bahremand, M; Schumacher, HR | 1 |
| Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM | 1 |
| Frost, A; Haegert, DG; Neville, C; Newkirk, MM; Shiroky, JB; Skelton, JD | 1 |
| Chan, CK; Flood, DA; Pruzanski, W | 1 |
| Lang, B; Peter, HH; Peters, T; Riegel, W | 1 |
| Batlle Gualda, E; Carro Martínez, A; Castellano Cuesta, JA; Pascual Gómez, E | 1 |
| González, T; Hernández-Beriaín, JA; Rodríguez-Lozano, B | 1 |
| Aspe de la Iglesia, B; Galdo Fernández, F; Graña Gil, J; Sánchez Bursón, J | 1 |
| Paulus, HE | 2 |
| Sienknecht, CW | 1 |
| Sigidin, IaA; Zhukovskaia, GN | 1 |
| Azuma, T; Uno-Komase, Y | 1 |
| Calabrese, LH; Clough, JD; Segal, AM; Taylor, JV; Valenzuela, R; Wilke, WS | 1 |
| Cathey, MA; Hawley, DJ; Wolfe, F | 1 |
| Sany, J | 1 |
| Gayraud, M; Guillevin, L | 1 |
| Ward, JR | 2 |
| Arnold, MH; Brooks, PM; Schwarzer, AC | 1 |
| Kumar, A; Malaviya, AN; Malaviya, R; Sharma, M; Singh, RJ; Singh, YN | 1 |
| Clough, JD; Perhala, RS; Segal, AM; Wilke, WS | 1 |
| Cloutier, JM; Faure, MP; Haraoui, B; Martel-Pelletier, J; Pelletier, JP | 1 |
| Blake, GJ | 1 |
| Antonelli, MA; Brick, JE; Moreland, LW | 1 |
| Bene, MC; Delorme, N; Fener, P; Guillemin, F; Pourel, J; Webanck, L | 1 |
| Bijlsma, JW; Teding van Berkhout, F; van der Veen, MJ | 1 |
| Lambert, RE; McGuire, JL; Mohle-Boetani, J; Perruquet, JL; Raffin, TA; Wollner, A | 1 |
| Boerbooms, AM; Doesburg, WH; Jeurissen, ME; Lemmens, AM; van de Putte, LB | 1 |
| Lee, P; Urowitz, MB | 1 |
| Basin, KS; Beardmore, TD; Escalante, A | 1 |
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| Couret, M; Cuchacovich, M; Daures, JP; Kaliski, S; Sany, J | 1 |
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| Alarcón, GS; Blackburn, WD | 2 |
| Austen, KF; Benincaso, AI; Coblyn, JS; Larkin, JK; Sperling, RI; Weinblatt, ME | 1 |
| Lee, S; Solomon, G | 1 |
| Anderson, L; Block, S; Germain, BF; Irby, R; Kaplan, H; Merriman, RC; Solomon, SD; Wall, B; Weinblatt, ME; Wolfe, F | 1 |
| Arnold, MH; Beller, EM; Brooks, PM; Kelly, DE; McCredie, M; O'Callaghan, J | 1 |
| Clough, JD; Kozlowski, RD; MacKenzie, AH; Segal, AM; Steinbrunner, JV; Wilke, WS | 1 |
| Maier, AL; Weinblatt, ME | 1 |
| Balabanova, RM; Bassam, B | 1 |
| Blonquist, LJ; Cannon, GW; Collette, LB; Reading, JC; Ward, JR | 1 |
| Kaplan, MM | 1 |
| Anderson, ST; Schwartz, GF | 1 |
| Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ | 1 |
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| Akama, H; Homma, M; Ichikawa, Y; Matsushita, Y; Shinozawa, T; Suzuki, Y; Tanaka, H; Yamada, H | 1 |
| Willkens, RF | 3 |
| Odeh, M | 1 |
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| Andonopoulos, AP; Drosos, AA; Moutsopoulos, HM; Psychos, D; Stefanaki-Nikou, S; Tsianos, EB | 1 |
| Drosos, AA; Karantanas, AH; Moutsopoulos, HM; Psychos, D; Tsampoulas, C | 1 |
| Ericksen, N; Furst, DE; Hash, L; Herman, RA; Koehnke, R; Porras, A; Riggs, CE; Veng-Pedersen, P | 1 |
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| Brückle, W | 1 |
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| Karger, T; Rau, R | 2 |
| Brick, JE; Chang, WL; Kujala, GA; Shamma'a, JM | 1 |
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| Miller, A | 1 |
| Alarcon, GS; Bennett, KJ; Bombardier, C; Buchanan, WW; Egger, M; Goldsmith, C; Grace, E; Guttadauria, M; Tugwell, P; Williams, HJ | 1 |
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| Galivan, J; Kamen, B; Kremer, JM; Streckfuss, A | 1 |
| Frenzel, H; Herborn, G; Karger, T; Rau, R | 1 |
| Klippel, JH; Shiroky, JB; Wilder, RL; Yocum, DE | 1 |
| Cyr, M; Goldstein, R; Karsh, J; McKendry, RJ; Morassut, P | 1 |
| Caspi, D; Segal, R; Tishler, M; Wigler, I; Yaron, M | 1 |
| Andreu, JL; Angeles Trujillo, M; Isasi, C; López-Martín, JA; Mulero, J; Palacio, S | 1 |
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| Cannon, GW; Carson, CW; Clegg, DO; Fehlauer, CS; Samuelson, CO; Ward, JR; Williams, HJ | 1 |
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| Caspi, D; Graff, E; Peretz, H; Segal, R; Tishler, M; Yaron, M | 1 |
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| Dalquen, P; Elsasser, S; Perruchoud, AP; Soler, M | 1 |
| Kaye, GI; Kremer, JM | 1 |
| Szanto, E | 2 |
| Boerbooms, AM; Jeurissen, ME; van de Putte, LB | 2 |
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| Yunus, MB | 1 |
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| Huang, YP; Miescher, PA; Zubler, RH | 1 |
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| Davis, RE | 1 |
| Altz-Smith, M; Baggott, JE; Morgan, SL | 1 |
| Fitzgerald, A; Grace, M; Russell, AS; Suarez-Almazor, ME | 1 |
| Dunky, A; Eberl, R; Fischer, M; Leeb, B; Ogris, E; Schenk, G; Tausch, G; Wohanka, A | 1 |
| Chamot, AM; Gerster, JC; Van Melle, G | 1 |
| Allen, NB; Caldwell, DS; Pisetsky, DS; Polisson, RP; Rice, JR; Shergy, WJ | 1 |
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| Bertken, RD; Xavier, AM | 1 |
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| Brooks, PM | 1 |
| Allegra, C; Chabner, B; Inghirami, G; Klippel, JH; Shiroky, J; Yarboro, C | 1 |
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| Coblyn, JS; Falchuk, KR; Fraser, PA; Holdsworth, DE; Trentham, DE; Weinblatt, ME; Weissman, BN | 1 |
| Berkenstadt, H; Green, L; Schattner, A | 1 |
| Kremer, JM; Lee, JK | 2 |
| Scott, DG | 1 |
| Bennett, K; Gent, M; Tugwell, P | 1 |
| Pugh, CB; Pugh, MC | 1 |
| McKendry, RJ; Searles, G | 1 |
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| Chatelanat, F; Favre, H; Huang, YP; Miescher, PA; Mihatsch, MJ; Zubler, R | 1 |
| Kirn, TF | 1 |
| Caspi, D; Fishel, B; Gazit, E; Rosenbach, TO; Segal, R; Tishler, M; Wigler, I; Yaron, M | 1 |
| Boerbooms, AM; Jeurissen, ME; Theunisse, H; Van de Putte, LB; Westgeest, AA | 1 |
| Zhukovskaia, GN | 1 |
| Caspi, D; Fishel, B; Segal, R; Tishler, M; Yaron, M | 1 |
| Brumage, M; Seitz, M; Trümper, L | 1 |
| Cannon, GW; Carson, CC; Clegg, DO; Egger, MJ; Leonard, PA; Ward, JR | 1 |
| Lally, ET; Pliskin, ME; Quinn, P | 1 |
| Acton, RT; Alarcón, GS; Barger, BO; Guyton, JM; Koopman, WJ | 1 |
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| Polisson, RP; St Clair, EW | 1 |
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| Malone, DG; Metcalfe, DD; Saavedra-Delgado, AM; Wilder, RL | 1 |
| Alarcón, GS; Billingsley, LM; Clegg, DO; Hardin, JG; Klippel, J; Luggen, ME; Polisson, RP; Singer, JZ; Szydlo, L; Willkens, RF | 1 |
| Agadzhanian, RN | 1 |
| Bartholomew, LE; Kremer, JM; Rynes, RI | 1 |
| Hamdy, H; Liver, JA; McKendry, RJ; Mierins, E | 1 |
| Bloch, D; Fries, J; Sherrer, Y; Strober, S | 1 |
| Acton, RT; Alarcón, GS; Barger, BO; Gispen, JG; Johnson, JJ; Koopman, WJ | 1 |
| Bertino, JR; Kremer, JM; Rodenhuis, S | 1 |
| Callahan, LF; Olsen, NJ; Pincus, T | 1 |
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| Healey, LA | 1 |
| Caspi, D; Rozenbach, TO; Tischler, M; Yaron, M | 1 |
| Bress, NM; Heller, K; Upchurch, KS | 1 |
| Kollberg, B; Sandstedt, B; Szanto, E | 1 |
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| Andersen, PA; Nordstrom, DM; Sharp, JT; West, SG | 1 |
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| Brussaard, HE; de Wit, RF; van Eijk, CL; van Seters, WA; van Toorn, DW | 1 |
| Lee, WM; Reynolds, FS | 1 |
| Bloch, DA; Fries, JF; Mitchell, DM; Roth, SH; Spitz, PW; Wolfe, F | 1 |
| Adams, EM; Boh, LE; Pitterle, ME; Schuna, AA; Sundstrom, WR | 1 |
| Dasgupta, M; Johnston, CA; Kovithavongs, T; Russell, AS | 1 |
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| Espinoza, CG; Espinoza, LR; Germain, BF; Vasey, FB | 1 |
| Bretscher, P; O'Callaghan, JW; Russell, AS | 1 |
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1019 review(s) available for methotrexate and Rheumatoid Arthritis
| Article | Year |
|---|---|
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Gastrointestinal Diseases; Humans; Methotrexate; Neoplasms | 2018 |
Methotrexate Hepatotoxicity Monitoring Guidelines in Psoriasis and Rheumatoid Arthritis: Is There a Consensus?
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Consensus; Diabetes Mellitus, Type 2; Humans; Methotrexate; Psoriasis | 2021 |
Intra-articular therapy with methotrexate or tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2021 |
Safety of long-term use of four common conventional disease modifying anti-rheumatic drugs in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sulfasalazine; Tumor Necrosis Factor-alpha | 2021 |
A review of liquid biopsy as a tool to assess epigenetic, cfDNA and miRNA variability as methotrexate response predictors in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell-Free Nucleic Acids; Epigenesis, Genetic; Humans; Liquid Biopsy; Methotrexate; MicroRNAs; Treatment Outcome | 2021 |
Pancytopenia after Low-Dose Methotrexate Therapy in Two Hemodialysis Patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pancytopenia; Renal Dialysis | 2022 |
Comparative efficacy and safety of etanercept biosimilars in comparison with etanercept in patients with rheumatoid arthritis who have insufficient response to methotrexate: A network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Network Meta-Analysis; Treatment Outcome | 2021 |
Methotrexate related cutaneous adverse drug reactions: a systematic literature review.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Spondylitis, Ankylosing; Young Adult | 2022 |
The lessebo effect in randomized controlled trials of rituximab in patients with rheumatoid arthritis: a meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome | 2023 |
Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2021 |
Pharmacomicrobiology of Methotrexate in Rheumatoid Arthritis: Gut Microbiome as Predictor of Therapeutic Response.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Gastrointestinal Microbiome; Humans; Methotrexate; Treatment Outcome | 2021 |
Effectiveness and adverse effects of anakinra in treatment of rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Methotrexate in early rheumatoid arthritis: Is the anchor drug still holding?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2022 |
[Innovative strategies for treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2022 |
Rheumatoid arthritis and myasthenia gravis: a case-based review of the therapeutic options.
Topics: Adalimumab; Arthritis, Rheumatoid; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Myasthenia Gravis | 2022 |
Clinical features of methotrexate osteopathy in rheumatic musculoskeletal disease: A systematic review.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases; Female; Humans; Methotrexate; Osteoporosis | 2022 |
New Evidence of Significant Association between EBV Presence and Lymphoproliferative Disorders Susceptibility in Patients with Rheumatoid Arthritis: A Systematic Review with Meta-Analysis.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Databases, Factual; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Lymphoma; Lymphoproliferative Disorders; Methotrexate; Prevalence | 2022 |
Experts document on methotrexate use in combined therapy with biological or targeted synthetic disease modifying drugs in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Evidence-Based Medicine; Humans; Methotrexate; Synthetic Drugs | 2022 |
Randomized Clinical Trials on the Efficacy and Safety of Tocilizumab in Subjects with Rheumatoid Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2023 |
Spontaneous regression of breast lymphoproliferative disorders after withdrawal of methotrexate in rheumatoid arthritis patients with Epstein-Barr virus infection: a case report and review of the literature.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Neoplasm Recurrence, Local | 2022 |
Janus Kinase Inhibitors Improve Disease Activity and Patient-Reported Outcomes in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of 24,135 Patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Humans; Janus Kinase Inhibitors; Janus Kinases; Methotrexate; Pain; Pain Management; Patient Reported Outcome Measures; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Factors influencing methotrexate and methotrexate polyglutamate in patients with rheumatoid arthritis: a systematic review of population pharmacokinetics.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Polyglutamic Acid | 2022 |
Comparison of immune checkpoint inhibitor-induced arthritis and reactive arthritis to inform therapeutic strategy.
Topics: Antirheumatic Agents; Arthritis, Reactive; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immune Checkpoint Inhibitors; Methotrexate; Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies | 2022 |
Treatment of relapsing polychondritis: a systematic review.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate; Polychondritis, Relapsing; Rituximab; Tumor Necrosis Factor Inhibitors | 2022 |
Use of parenteral methotrexate in rheumatic diseases: A systematic review.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Humans; Methotrexate; Rheumatic Diseases | 2022 |
Treatment of early rheumatoid arthritis: Methotrexate and beyond.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Meta-Analyses on the Effects of Disease-Modifying Antirheumatic Drugs on the Most Relevant Patient-Reported Outcome Domains in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2023 |
Application and pharmacological mechanism of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2022 |
Methotrexate use reduces mortality risk in rheumatoid arthritis: A systematic review and meta-analysis of cohort studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Humans; Lung Diseases, Interstitial; Methotrexate | 2022 |
Oral methotrexate at doses 15-25 mg/week is non-inferior to parenteral regarding efficacy and safety in the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide | 2022 |
Rheumatoid arthritis: advances in treatment strategies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate | 2023 |
Novel insights into the management of rheumatoid arthritis: one year in review 2022.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Janus Kinase Inhibitors; Methotrexate | 2022 |
Methotrexate induced neurotoxicity in a patient with rheumatoid arthritis on rituximab therapy: a case-based review.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Leukoencephalopathies; Methotrexate; Rituximab | 2022 |
Upadacitinib for the Treatment of Rheumatoid Arthritis: An Extensive Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Methotrexate; Randomized Controlled Trials as Topic; Venous Thromboembolism | 2023 |
Clinical prediction models for methotrexate treatment outcomes in patients with rheumatoid arthritis: A systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Models, Statistical; Prognosis; Treatment Outcome | 2022 |
Advance in bone destruction participated by JAK/STAT in rheumatoid arthritis and therapeutic effect of JAK/STAT inhibitors.
Topics: Arthritis, Rheumatoid; Bone Resorption; Humans; Inflammation; Janus Kinase Inhibitors; Janus Kinases; Methotrexate; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; STAT Transcription Factors | 2022 |
Treatment Guidelines in Rheumatoid Arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Can Patients With Controlled Rheumatoid Arthritis Taper Methotrexate From Targeted Therapy and Sustain Remission? A Systematic Review and Metaanalysis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Observational Studies as Topic; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal disease: a systematic literature review informing EULAR points to consider.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Monitoring; Humans; Methotrexate | 2022 |
Efficacy of tripterygium glycosides (TG) in rheumatoid arthritis as a disease-modifying anti-rheumatic drug (DMARD) in combination with conventional DMARDs: A systematic review and meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Glycosides; Humans; Interleukin-1; Interleukin-6; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome; Tripterygium; Tumor Necrosis Factor-alpha | 2022 |
Association Between Low-Dose Methotrexate Exposure and Melanoma: A Systematic Review and Meta-analysis.
Topics: Arthritis, Rheumatoid; Humans; Melanoma; Melanoma, Cutaneous Malignant; Methotrexate; Psoriasis | 2022 |
Perioperative management of disease-modifying antirheumatic drugs and other immunomodulators.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunologic Factors; Lupus Erythematosus, Systemic; Methotrexate | 2022 |
Primary central nervous system other iatrogenic immunodeficiency-associated lymphoproliferative disorders presenting as extraosseous plasmacytoma with a progressive clinical course: A case report and literature review.
Topics: Aged; Arthritis, Rheumatoid; Central Nervous System; Disease Progression; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Iatrogenic Disease; Immunosuppressive Agents; Lymphoproliferative Disorders; Male; Methotrexate; Neoplasm Recurrence, Local; Plasmacytoma | 2023 |
A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment.
Topics: Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Neoplasms | 2022 |
Withdrawal of MTX in rheumatoid arthritis patients on bDMARD/tsDMARD plus methotrexate at target: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2023 |
Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Inflammation; Leflunomide; Liver Cirrhosis; Methotrexate; Non-alcoholic Fatty Liver Disease; Risk Factors | 2022 |
Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Methotrexate | 2022 |
miRNA-Mediated Epigenetic Regulation of Treatment Response in RA Patients-A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Epigenesis, Genetic; Humans; Methotrexate; MicroRNAs; Rituximab; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biosimilar Pharmaceuticals; Glucocorticoids; Humans; Janus Kinase Inhibitors; Methotrexate; Rheumatology | 2023 |
Drug-induced accelerated nodulosis: review of the literature.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Rheumatoid Nodule | 2023 |
Subcutaneous injection of methotrexate: Advantages in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2023 |
Pharmacological strategies for mitigating anti-TNF biologic immunogenicity in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Influence of active versus placebo control on treatment responses in randomised controlled trials in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Piperidines; Randomized Controlled Trials as Topic | 2023 |
The Yin-Yang Pharmacomicrobiomics on Treatment Response in Inflammatory Arthritides: A Narrative Review.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Interleukin-12; Interleukin-17; Janus Kinase Inhibitors; Methotrexate; Rituximab; Yin-Yang | 2022 |
Diffuse lung involvement in rheumatoid arthritis: a respiratory physician's perspective.
Topics: Arthritis, Rheumatoid; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Prognosis | 2023 |
Glucocorticoid use in rheumatoid arthritis patients and the onset of pneumonia: a systematic review and meta-analysis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate; Middle Aged; Pneumonia | 2023 |
Tripterygium wilfordii Hook F combination therapy with methotrexate for rheumatoid arthritis: An updated meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Plant Extracts; Randomized Controlled Trials as Topic; Tripterygium | 2023 |
[DMARD (disease-modifying antirheumatic drug) treatment in patients with former or current cancer].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Janus Kinase Inhibitors; Methotrexate; Neoplasms | 2023 |
The efficacy and safety of olokizumab for rheumatoid arthritis: a systematic review, pairwise, and network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Network Meta-Analysis; Treatment Outcome | 2023 |
Preventive interventions in individuals at risk for Rheumatoid Arthritis: State of the art and perspectives.
Topics: Arthritis, Rheumatoid; Autoantibodies; Humans; Methotrexate; Risk Factors; Rituximab | 2023 |
Necrotizing Scleritis and Rheumatoid Arthritis: A Clinical Case Report Supported by A Brief Review with Risk of Bias Analysis.
Topics: Arthritis, Rheumatoid; Female; Humans; Inflammation; Methotrexate; Middle Aged; Scleritis; Tumor Necrosis Factor Inhibitors | 2023 |
The Proportion of Patients With Rheumatoid Arthritis Achieving ACR20/50/70; Consistent Patterns of a 60/40/20 as Demonstrated by a Systematic Review and Meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Pyrroles; Treatment Outcome | 2023 |
Analysis of efficacy and safety of abatacept for rheumatoid arthritis: systematic review and meta-analysis.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2023 |
Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Network Meta-Analysis; Tripterygium | 2023 |
How are rheumatologists from Argentina managing patients with arthralgias suspicious for progressing to rheumatoid arthritis?
Topics: Argentina; Arthralgia; Arthritis, Rheumatoid; Humans; Methotrexate; Rheumatologists; Surveys and Questionnaires | 2023 |
Treatment of Inflammatory Arthritis in Systemic Sclerosis.
Topics: Arthralgia; Arthritis, Rheumatoid; Humans; Methotrexate; Quality of Life; Scleroderma, Systemic | 2023 |
Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Outcome | 2023 |
JAK inhibitors and the risk of malignancy: a meta-analysis across disease indications.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Methotrexate; Neoplasms | 2023 |
Cost-utility analysis of biologic disease-modifying antirheumatic drugs (bDMARDs), targeted synthetic DMARDs (tsDMARDs) and biosimilar DMARDs (bsDMARDs) combined with methotrexate for Thai rheumatoid arthritis patients with high disease activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; Humans; Methotrexate; Network Meta-Analysis; Quality of Life; Southeast Asian People | 2023 |
What are the core recommendations for rheumatoid arthritis care? Systematic review of clinical practice guidelines.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Practice Guidelines as Topic; Sulfasalazine | 2023 |
Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Inflammation; Methotrexate; Mice | 2023 |
Methotrexate-associated lymphoproliferative disorder presenting as an ulcer with tendon exposure on the dorsum of the hand: a case report and literature review.
Topics: Aged; Arthritis, Rheumatoid; Female; Hand; Humans; Infant; Lymphoproliferative Disorders; Methotrexate; Ulcer | 2023 |
Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Network Meta-Analysis; Rituximab; Tumor Necrosis Factor Inhibitors | 2023 |
Incidence, risk factors, and prognosis of acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Idiopathic Pulmonary Fibrosis; Incidence; Lung Diseases, Interstitial; Male; Methotrexate; Prognosis; Risk Factors | 2023 |
Safety and efficacy of mesenchymal stem cells therapy in the treatment of rheumatoid arthritis disease: A systematic review and meta-analysis of clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2023 |
Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review.
Topics: Arthritis, Rheumatoid; Autoantibodies; Humans; Lung Diseases, Interstitial; Methotrexate; Smoking | 2023 |
Central Nervous System Lymphoproliferative Disorder Secondary to Methotrexate: A Systematic Literature Review and Case Illustration.
Topics: Arthritis, Rheumatoid; Central Nervous System; Central Nervous System Diseases; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate | 2023 |
Relative Remission and Low Disease Activity Rates of Tofacitinib, Baricitinib, Upadacitinib, and Filgotinib versus Methotrexate in Patients with Disease-Modifying Antirheumatic Drug-Naive Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2023 |
Treating rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Methotrexate | 2023 |
The Cardiovascular Burden of Rheumatoid Arthritis - Implications for Treatment.
Topics: Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors | 2023 |
Monotreatment With Conventional Antirheumatic Drugs or Glucocorticoids in Rheumatoid Arthritis: A Network Meta-Analysis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Network Meta-Analysis | 2023 |
Elderly-Onset Rheumatoid Arthritis: Characteristics and Treatment Options.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2023 |
Low rates of remission with methotrexate monotherapy in rheumatoid arthritis: review of randomised controlled trials could point towards a paradigm shift.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Drug Therapy, Combination; Glucocorticoids; Humans; Immunologic Factors; Methotrexate; Molecular Targeted Therapy; Randomized Controlled Trials as Topic; Remission Induction; Tumor Necrosis Factor Inhibitors | 2019 |
[Role of janus kinase inhibitors in the treatment of rheumatic diseases].
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome | 2019 |
Comparison of oral versus parenteral methotrexate in the treatment of rheumatoid arthritis: A meta-analysis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Outcome | 2019 |
Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials.
Topics: Anemia; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Leukopenia; Methotrexate; Neutropenia; Pancytopenia; Randomized Controlled Trials as Topic; Rheumatic Diseases; Severity of Illness Index; Thrombocytopenia; Vitamin B Complex | 2020 |
Methotrexate and interstitial lung disease: controversies and questions. A narrative review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Lung Diseases, Interstitial; Methotrexate; Observational Studies as Topic; Pneumonia | 2019 |
[RITUXIMAB IN RHEUMATOID ARTHRITIS - THERAPEUTIC ASPECTS BASED ON 18 YEARS OF GLOBAL EXPERIENCE].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Israel; Methotrexate; Rituximab; Treatment Outcome | 2019 |
[Meta-analysis of laboratory index of Tripterygium Glycosides Tablets in treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Glycosides; Humans; Methotrexate; Randomized Controlled Trials as Topic; Tablets; Treatment Outcome; Tripterygium | 2019 |
[Clinical symptoms effect of Tripterygium Glycosides Tablets alone or combined with methotrexate in treatment of rheumatoid arthritis: a Meta-analysis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Glycosides; Humans; Methotrexate; Tablets; Treatment Outcome; Tripterygium | 2019 |
Folyl polyglutamate synthethase (FPGS) gene polymorphisms may influence methotrexate adverse events in South Indian Tamil Rheumatoid Arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gastrointestinal Diseases; Humans; India; Male; Methotrexate; Middle Aged; Peptide Synthases; Polymorphism, Single Nucleotide; Prospective Studies | 2020 |
Predictive genetic biomarkers for the efficacy of methotrexate in rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Markers; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Treatment Outcome | 2020 |
Upadacitinib: First Approval.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Methotrexate; Protein Kinase Inhibitors; United States | 2019 |
Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic | 2019 |
Methotrexate an Old Drug with New Tricks.
Topics: Adenosine; Alarmins; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cytokines; Folic Acid; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Matrix Metalloproteinases; Methotrexate; NF-kappa B; Polyamines; Prostaglandins; Reactive Oxygen Species | 2019 |
Methotrexate and Vasculoprotection: Mechanistic Insights and Potential Therapeutic Applications in Old Age.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Humans; Meta-Analysis as Topic; Methotrexate; Observational Studies as Topic; Systematic Reviews as Topic | 2019 |
Comparison of the efficacy and safety of tofacitinib and filgotinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Piperidines; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2020 |
Immune response in LPD during methotrexate administration (MTX-LPD) in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate | 2019 |
Relative efficacy and safety of iguratimod monotherapy for the treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Chromones; Humans; Methotrexate; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome | 2020 |
A systematic review and meta-analysis of rituximab combined with methotrexate versus methotrexate alone in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Rituximab | 2020 |
Management issues in rheumatoid arthritis-associated interstitial lung disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Lung Diseases, Interstitial; Methotrexate; Prognosis | 2020 |
Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Biological Availability; Gastrointestinal Microbiome; Humans; Methotrexate; Mice; Precision Medicine; Spondylarthritis; Tumor Necrosis Factor Inhibitors | 2020 |
[Small molecules treatment in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2020 |
Most Appropriate Conventional Disease-Modifying Antirheumatic Drug to Combine With Different Advanced Therapies in Rheumatoid Arthritis: A Systematic Literature Review With Meta-Analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Molecular Targeted Therapy; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2021 |
[Systematic reviews of effects of Tripterygium Glycosides Tablets on pro-inflammatory factors in rheumatoid arthritis].
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Drugs, Chinese Herbal; Glycosides; Humans; Leflunomide; Methotrexate; Tablets; Tripterygium | 2020 |
[Meta-analysis of RCT studies on clinical efficacy of single administration of Tripterygium Glycosides Tablets or combined administration with methotrexate against rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Glycosides; Humans; Methotrexate; Randomized Controlled Trials as Topic; Reproducibility of Results; Tablets; Treatment Outcome; Tripterygium | 2020 |
How does methotrexate work?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Line; Crohn Disease; Folic Acid; Humans; Inflammation; Janus Kinases; MAP Kinase Signaling System; Methotrexate; Psoriasis; Signal Transduction; STAT Transcription Factors | 2020 |
Comparative Efficacy of JAK Inhibitors for Moderate-To-Severe Rheumatoid Arthritis: A Network Meta-Analysis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Network Meta-Analysis; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfonamides | 2020 |
Comparative efficacy and safety of 100 mg and 200 mg filgotinib administered to patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials
.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Janus Kinase 1; Methotrexate; Network Meta-Analysis; Pyridines; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles | 2020 |
Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2021 |
Comparative effectiveness of improvement in pain and physical function for baricitinib versus adalimumab, tocilizumab and tofacitinib monotherapies in rheumatoid arthritis patients who are naïve to treatment with biologic or conventional synthetic disease
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biological Products; Clinical Trials, Phase III as Topic; Disability Evaluation; Humans; Methotrexate; Network Meta-Analysis; Pain; Pain Measurement; Piperidines; Purines; Pyrazoles; Pyrimidines; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome | 2020 |
Molecular mechanism of action and pharmacokinetic properties of methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Methotrexate; Polyglutamic Acid; Prostaglandin-Endoperoxide Synthases; Sarcoidosis; Tetrahydrofolate Dehydrogenase | 2020 |
Incident diabetes associated with hydroxychloroquine, methotrexate, biologics and glucocorticoids in rheumatoid arthritis: A systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus; Glucocorticoids; Humans; Hydroxychloroquine; Incidence; Methotrexate; Risk Assessment; Tumor Necrosis Factor-alpha | 2020 |
Using pharmacogenetics to predict methotrexate response in rheumatoid arthritis patients.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Genome-Wide Association Study; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precision Medicine; Treatment Outcome | 2020 |
Does methotrexate cause interstitial lung disease in rheumatoid arthritis: What is the evidence?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Predictive Value of Tests; Risk Assessment; Risk Factors; Treatment Outcome | 2020 |
Therapeutic Options and Cost-Effectiveness for Rheumatoid Arthritis Treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate | 2020 |
Effect of methotrexate use on the development of type 2 diabetes in rheumatoid arthritis patients: A systematic review and meta-analysis.
Topics: Age Factors; Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Humans; Methotrexate; Risk; Severity of Illness Index | 2020 |
Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Drug Therapy, Combination; Equivalence Trials as Topic; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Failure | 2020 |
Methotrexate and rheumatoid arthritis associated interstitial lung disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Humans; Lung Diseases, Interstitial; Methotrexate | 2021 |
Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Flavonoids; Humans; Methotrexate; Nanostructures; Plant Oils; Polyphenols | 2020 |
The advances of methotrexate resistance in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Resistance; Humans; Methotrexate; Signal Transduction; Treatment Outcome | 2020 |
Rheumatoid arthritis-associated interstitial lung disease: an overview of epidemiology, pathogenesis and management.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Methotrexate | 2021 |
Systematic review of recommendations on the use of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Registries; Rheumatologists | 2021 |
Rare Oral Presentation of a Mycophenolate Mofetil-Related Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder (MMF-OIA-LPD) Lesion: A Case Report and Literature Review.
Topics: Aged; Arthritis, Rheumatoid; Humans; Iatrogenic Disease; Lymphoproliferative Disorders; Male; Methotrexate; Mycophenolic Acid | 2021 |
Cost-Effectiveness of Tofacitinib for Patients with Moderate-to-Severe Rheumatoid Arthritis in China.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Cost-Benefit Analysis; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Treatment Outcome | 2020 |
Comparative study of the efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib versus methotrexate for disease-modifying antirheumatic drug-naïve patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Sulfonamides; Treatment Outcome; Triazoles | 2021 |
Updates on management strategies of hepatitis B virus reactivation in patients with resolved hepatitis virus B infection undergoing immunosuppressive therapy in rheumatology and the current situation in Niigata Rheumatic Center.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Japan; Male; Methotrexate; Middle Aged; Rheumatic Diseases; Virus Activation | 2021 |
Methotrexate pneumonitis in a patient with Crohn's disease, during the COVID pandemic: An unusual clinical case and review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; Crohn Disease; Female; Humans; Methotrexate; Middle Aged; Pneumonia | 2021 |
Methotrexate osteopathy: five cases and systematic literature review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Diseases; Child; Humans; Methotrexate; Osteoporosis | 2021 |
Traditional and modern management strategies for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Interleukin-1; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha; Young Adult | 2021 |
Efficacy of methotrexate in reducing the risk of bone erosion in patients with rheumatoid arthritis: a systematic review of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Efficacy and safety of iguratimod combined with methotrexate vs. methotrexate alone in rheumatoid arthritis : A systematic review and meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Chromones; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome | 2021 |
Baricitinib inhibits structural joint damage progression in patients with rheumatoid arthritis-a comprehensive review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Methotrexate; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2021 |
The effects of drug transporters on the efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; ATP-Binding Cassette Transporters; Cytokines; Humans; Inactivation, Metabolic; Methotrexate; Organic Anion Transporters; Tissue Distribution | 2021 |
Upadacitinib in Rheumatoid Arthritis: A Benefit-Risk Assessment Across a Phase III Program.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Risk Assessment; Treatment Outcome | 2021 |
Risk for infections with glucocorticoids and DMARDs in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Glucocorticoids; Humans; Methotrexate | 2021 |
Methotrexate can prevent cardiovascular events in patients with rheumatoid arthritis: An updated meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate | 2021 |
Risk factors for hypertension in rheumatoid arthritis patients-A systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hypertension; Methotrexate; Middle Aged; Risk Factors | 2021 |
Topics: Arthritis, Rheumatoid; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Respiratory Insufficiency | 2021 |
[Meta-analysis of efficacy and safety of sinomenine combined with methotrexate in treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Humans; Methotrexate; Morphinans | 2021 |
[Glucocorticoid-free and low-dose glucocorticoid treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Treatment Outcome | 2021 |
Influence of RFC1 c.80A>G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Genetic | 2021 |
Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Glucosides; Humans; Methotrexate; Paeonia; Phytochemicals; Phytotherapy; Plant Roots; Randomized Controlled Trials as Topic | 2021 |
Helicobacter canis bacteraemia in a rheumatoid arthritis patient treated with tofacitinib: case report and literature review.
Topics: Aged; Animals; Arthritis, Rheumatoid; Bacteremia; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Helicobacter; Humans; Methotrexate; Methylprednisolone; Piperidines; Pyrimidines; Sheep; Treatment Outcome | 2021 |
Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Japan; Methotrexate; Practice Guidelines as Topic; Rheumatology | 2022 |
Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Prevalence and predictors of adverse events with methotrexate mono- and combination-therapy for rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prevalence; Risk Factors | 2021 |
Iguratimod combination therapy compared with methotrexate monotherapy for the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Humans; Methotrexate; Sulfonamides | 2021 |
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Etanercept; Heart Failure; Humans; Hydroxychloroquine; Inflammation; Methotrexate; Myocardial Infarction; Myocardial Ischemia; Risk Factors; Stroke Volume; Sulfasalazine | 2021 |
Clinical use of Jak 1 inhibitors for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Janus Kinase Inhibitors; Methotrexate; Practice Patterns, Physicians'; Pyridines; Triazoles | 2021 |
Comparative efficacy and safety of adalimumab biosimilars and adalimumab in patients with rheumatoid arthritis presenting an insufficient response to methotrexate: a network meta-analysis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Treatment Outcome | 2023 |
A systematic review and network meta-analysis of the safety of early interventional treatments in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Network Meta-Analysis; Randomized Controlled Trials as Topic; Secondary Prevention; Steroids; Treatment Outcome | 2021 |
Methotrexate and cardiovascular risk in rheumatic diseases:A comprehensive review.
Topics: Animals; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Inflammation; Methotrexate; Oxidative Stress; Psoriasis | 2021 |
Epstein-Barr virus-related lymphoma in rheumatoid arthritis: implications for long-term usage of immunosuppressive drugs and review of the literature.
Topics: Abatacept; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate | 2022 |
Current jakinibs for the treatment of rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Kidney Diseases; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome | 2021 |
Fusion proteins of biologic agents in the treatment of rheumatoid arthritis (RA): A network meta-analysis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Drug Therapy, Combination; Etanercept; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Network Meta-Analysis | 2021 |
What dose of folic acid to use with methotrexate in rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Combinations; Folic Acid; Humans; Methotrexate; Vitamin B Complex | 2021 |
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Humans; Methotrexate; Psoriasis | 2021 |
Comparative efficacy and safety of tumor necrosis factor inhibitors and their biosimilars in patients with rheumatoid arthritis having an insufficient response to methotrexate : A network meta-analysis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Etanercept; Humans; Infliximab; Methotrexate; Network Meta-Analysis; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Comparative efficacy and safety of infliximab and its biosimilars in patients with rheumatoid arthritis presenting an insufficient response to methotrexate : A network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Network Meta-Analysis; Treatment Outcome | 2023 |
Comparison of the efficacy and safety of tocilizumab, sarilumab, and sirukumab in comparison with adalimumab as monotherapy in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Methotrexate-Induced Cutaneous Ulcers: A Rare Side Effect.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Skin Ulcer; Ulcer | 2021 |
Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate; Quality of Life; Severity of Illness Index | 2021 |
Comparative efficacy and tolerability of sarilumab 150 and 200 mg in patients with active rheumatoid arthritis : A Bayesian network meta-analysis of randomized controlled trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Humans; Methotrexate; Network Meta-Analysis; Randomized Controlled Trials as Topic; Treatment Outcome | 2018 |
Efficacy of glucocorticoids, conventional and targeted synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Piperidines; Practice Guidelines as Topic; Purines; Pyrazoles; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sulfonamides | 2017 |
Lactation and Management of Postpartum Disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Feeding; Contraindications; Cyclophosphamide; Disease Progression; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Lactation; Lupus Erythematosus, Systemic; Methotrexate; Postpartum Period; Rheumatic Diseases; Tumor Necrosis Factor-alpha | 2017 |
Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis.
Topics: Abatacept; Adalimumab; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Etanercept; Humans; Infliximab; Methotrexate; Methylprednisolone; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab | 2017 |
Lack of association between MTHFR A1298C polymorphism and outcome of methotrexate treatment in rheumatoid arthritis patients: evidence from a systematic review and meta-analysis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Pharmacogenetics; Pharmacogenomic Variants; Treatment Outcome | 2017 |
Certolizumab Pegol for Treating Rheumatoid Arthritis Following Inadequate Response to a TNF-α Inhibitor: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost-Benefit Analysis; Humans; Methotrexate; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Technology Assessment, Biomedical; Tumor Necrosis Factor-alpha | 2017 |
Methotrexate in the Treatment of Psoriasis and Rheumatoid Arthritis: Mechanistic Insights, Current Issues and Novel Delivery Approaches.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Methotrexate; Psoriasis | 2017 |
Abatacept: A Review in Rheumatoid Arthritis.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Novel treatment strategies in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Methotrexate | 2017 |
Methotrexate-Related Lymphoproliferative Disorder in Patients With Osteonecrosis of the Jaw: A 3-Case Report and Literature Review.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Debridement; Female; Humans; Immunohistochemistry; Lymphoproliferative Disorders; Male; Mandibular Diseases; Maxillary Diseases; Methotrexate; Osteonecrosis; Risk Factors | 2018 |
Precision Medicine in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pharmacogenetics; Precision Medicine | 2017 |
Methotrexate-associated lymphoproliferative disorder.
Topics: Age Factors; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; Humans; Immunity, Cellular; Lymphoproliferative Disorders; Male; Methotrexate; Prognosis; Risk Factors | 2017 |
A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucosides; Humans; Methotrexate; Paeonia; Phytotherapy; Plant Extracts; Treatment Outcome | 2018 |
Lymphoproliferative disorders in patients with rheumatoid arthritis in the era of widespread use of methotrexate: A review of the literature and current perspective.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate | 2018 |
A review of tofacitinib efficacy in rheumatoid arthritis patients who have had an inadequate response or intolerance to methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Janus Kinase Inhibitors; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
[Ocular involvement in rheumatoid arthritis, connective tissue diseases and vasculitis].
Topics: Acute Disease; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Collagen Diseases; Cross-Sectional Studies; Eye Diseases; Giant Cell Arteritis; Humans; Immunosuppressive Agents; Keratoconjunctivitis Sicca; Lupus Erythematosus, Systemic; Methotrexate; Retinal Diseases; Scleritis; Uveitis, Anterior; Vascular Diseases | 2017 |
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Humans; Immunoglobulin Fab Fragments; Methotrexate; Randomized Controlled Trials as Topic; Withholding Treatment | 2017 |
[Perioperative management of immunosuppressive treatment in patients undergoing joint surgery].
Topics: Adrenal Cortex Hormones; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Biological Products; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Perioperative Care; Risk Factors; Sulfasalazine; Surgical Wound Infection; Wound Healing | 2017 |
Severe Harm and Death Associated With Errors and Drug Interactions Involving Low-Dose Methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cause of Death; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Medication Errors; Methotrexate; Middle Aged; Risk Assessment; Severity of Illness Index | 2017 |
Tocilizumab: A Review in Rheumatoid Arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Receptors, Interleukin-6 | 2017 |
Tofacitinib: A Review in Rheumatoid Arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Janus Kinases; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2017 |
TYMS polymorphisms and responsiveness to or toxicity of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Polymorphism, Genetic; Thymidylate Synthase | 2018 |
Comparative efficacy and safety of biosimilar adalimumab and originator adalimumab in combination with methotrexate in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Adalimumab; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Treatment Outcome | 2018 |
Rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Early Diagnosis; Epigenomics; Glucocorticoids; Humans; Mass Screening; Methotrexate; Quality of Life; Risk Factors | 2018 |
Structural joint damage and hand bone loss in patients with rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Resorption; Disease Progression; Hand Bones; Humans; Joints; Methotrexate; Radiography; Randomized Controlled Trials as Topic; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2018 |
Predicting methotrexate resistance in rheumatoid arthritis patients.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Humans; Immunity, Cellular; Inflammation Mediators; Methotrexate; Predictive Value of Tests; Treatment Outcome | 2018 |
Tofacitinib for Treating Rheumatoid Arthritis After the Failure of Disease-Modifying Anti-rheumatic Drugs: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Drug Resistance; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quality-Adjusted Life Years; Technology Assessment, Biomedical | 2018 |
Comparative efficacy and safety of TNF-inhibitor plus methotrexate versus oral triple therapy in patients with active rheumatoid arthritis inadequately responding to methotrexate: A meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2018 |
Serum drug levels of biologic agents in the management of rheumatoid arthritis and spondyloarthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Spondylarthritis | 2018 |
Role of Methotrexate in the Management of Psoriatic Arthritis.
Topics: Antineoplastic Agents; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate | 2018 |
Comparative efficacy and safety of biosimilar-infliximab and originator-infliximab in combination with methotrexate in patients with active rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Topics: Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Odds Ratio; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome | 2018 |
Baricitinib: A Review in Rheumatoid Arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Janus Kinase 1; Janus Kinase 2; Methotrexate; Purines; Pyrazoles; Sulfonamides | 2018 |
Targeting Acquired Hemophilia A with Rheumatoid Arthritis by a Rituximab Shot: A Case Report and Review of the Literature.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Hemophilia A; Humans; Male; Methotrexate; Rituximab | 2018 |
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Genome-Wide Association Study; Humans; Methotrexate; Neuregulins; Severity of Illness Index; Transcription Factors | 2018 |
Rheumatoid arthritis and lymphoma: Incidence, pathogenesis, biology, and outcome.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Incidence; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Risk Factors | 2018 |
Pragmaticism of Randomized Controlled Trials of Biologic Treatment With Methotrexate in Rheumatoid Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2019 |
Sarilumab: A Review in Moderate to Severe Rheumatoid Arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Europe; Humans; Japan; Methotrexate; Receptors, Interleukin-6; Treatment Outcome; Tumor Necrosis Factor-alpha; United States | 2018 |
Effects and safety of Sinomenine in treatment of rheumatoid arthritis contrast to methotrexate: a systematic review and Meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Drugs, Chinese Herbal; Humans; Methotrexate; Morphinans; Randomized Controlled Trials as Topic; Treatment Outcome | 2016 |
[S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Germany; Glucocorticoids; Humans; Methotrexate | 2018 |
Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 2019 |
Some days you win.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Ill-Housed Persons; Male; Methotrexate; Middle Aged; Physical Therapy Modalities; Rheumatology | 2018 |
Influence of disease-modifying antirheumatic drugs on oxidative and nitrosative stress in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Infliximab; Leflunomide; Methotrexate; Nitrosative Stress; Oxidative Stress | 2018 |
Methotrexate mechanism in treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Molecular Targeted Therapy; Prognosis; Reactive Oxygen Species; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Systematic review and network meta-analysis: effect of biologics on radiographic progression in rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Methotrexate; Network Meta-Analysis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Diagnosis and Management of Rheumatoid Arthritis: A Review.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Radiography; Risk Factors | 2018 |
Upadacitinib for the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2019 |
Added value of combining methotrexate with a biological agent compared to biological monotherapy in rheumatoid arthritis patients: A systematic review and meta-analysis of randomised trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
Should a patient with rheumatoid arthritis be a kidney donor?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glomerular Filtration Rate; Humans; Kidney Transplantation; Living Donors; Methotrexate; Middle Aged; Risk Factors | 2019 |
Comparative efficacy and safety of biosimilar rituximab and originator rituximab in combination with methotrexate in patients with active rheumatoid arthritis: A Bayesian network meta-analysis
.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome | 2019 |
Can patients on methotrexate receive live vaccines?
Topics: Arthritis, Rheumatoid; Chickenpox Vaccine; Herpes Zoster Vaccine; Humans; Immunocompromised Host; Immunosuppressive Agents; Measles-Mumps-Rubella Vaccine; Methotrexate; Patient Safety; Patient Selection; Risk Assessment; Vaccination; Vaccines, Attenuated | 2019 |
A Bayesian mixed treatment comparison of efficacy of biologics and small molecules in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Factors; Drug Therapy, Combination; Etanercept; Humans; Infliximab; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome | 2019 |
Long-Term Efficacy of Tumor Necrosis Factor Inhibitors for the Treatment of Methotrexate-Naïve Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Methotrexate; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2019 |
[Cardiovascular comorbidities in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Comorbidity; Humans; Methotrexate; Risk Factors | 2019 |
FKB327: An Adalimumab Biosimilar.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Humans; Methotrexate; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2019 |
Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchial Diseases; Bronchoscopy; Female; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2019 |
Comparative efficacy and safety of 15 and 30 mg upadacitinib administered to patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Network Meta-Analysis; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Janus Kinase Inhibitors; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome | 2019 |
[Pulmonary involvement in rheumatoid arthritis].
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Humans; Lung Diseases, Interstitial; Methotrexate | 2019 |
Epidemiology of rheumatoid arthritis, clinical aspects and socio-economic determinants in Pakistani patients: A systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Cardiovascular Diseases; Comorbidity; Cost of Illness; Depression; Depressive Disorder; Fibromyalgia; Methotrexate; Osteoporosis; Pakistan; Prevalence; Risk Factors; Social Class | 2019 |
Is prediction of clinical response to methotrexate in individual rheumatoid arthritis patients possible? A systematic literature review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Rheumatology; Treatment Outcome | 2020 |
Association between
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Female; Genetic Association Studies; Humans; Male; Methotrexate; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Treatment Outcome | 2019 |
Patient Preferences for Disease-modifying Antirheumatic Drug Treatment in Rheumatoid Arthritis: A Systematic Review.
Topics: Adalimumab; Administration, Intravenous; Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Patient Preference; Piperidines; Pyrimidines; Quality of Life; Treatment Outcome | 2020 |
Tofacitinib for the treatment of rheumatoid arthritis: an update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2019 |
[Comorbidities-Their role in the treat to target concept for rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Comorbidity; Humans; Infection Control; Infections; Methotrexate; Remission Induction | 2019 |
JAK3-selective inhibitor peficitinib for the treatment of rheumatoid arthritis.
Topics: Adamantane; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Humans; Janus Kinase 3; Janus Kinase Inhibitors; Methotrexate; Niacinamide; Piperidines; Pyrimidines; Pyrroles | 2019 |
Cerebral Trypanosomiasis in an Immunocompromised Patient: Case Report and Review of the Literature.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Chagas Disease; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Meningoencephalitis; Methotrexate | 2019 |
Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2019 |
Comparison of the efficacy and safety of tofacitinib and upadacitinib in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2019 |
Hepatic methotrexate-associated lymphoproliferative disorders identified by multiple liver tumors: a case report and review of the literature.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Lymphoproliferative Disorders; Male; Methotrexate | 2019 |
Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders.
Topics: Animals; Arthritis, Rheumatoid; Disease Management; Humans; Iatrogenic Disease; Immunologic Deficiency Syndromes; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate | 2019 |
Optimising low-dose methotrexate for rheumatoid arthritis-A review.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate; Polyglutamic Acid; Practice Patterns, Physicians' | 2019 |
Does Triple Conventional Synthetic Disease-Modifying Antirheumatic Drug Therapy Improve upon Methotrexate as the Initial Treatment of Choice for a Rheumatoid Arthritis Patient?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comparative Effectiveness Research; Drug Therapy, Combination; Humans; Methotrexate | 2019 |
Perspective and Potential of A2A and A3 Adenosine Receptors as Therapeutic Targets for the Treatment of Rheumatoid Arthritis.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Receptor, Adenosine A2A; Receptor, Adenosine A3; Signal Transduction | 2019 |
[Treatment algorithm for rheumatoid arthritis : According to the S2e guidelines 2018].
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Practice Guidelines as Topic; Remission Induction; Severity of Illness Index; Treatment Outcome | 2019 |
Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Network Meta-Analysis | 2019 |
Performance of the 2010 classification criteria for rheumatoid arthritis: a systematic literature review and a meta-analysis.
Topics: Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Humans; Methotrexate; PubMed; Reference Standards; Rheumatology; Treatment Outcome | 2013 |
Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Genetic Markers; Genetic Variation; Humans; Methotrexate; Pharmacogenetics; Precision Medicine; Rheumatology; Treatment Outcome | 2013 |
[Methotrexate as combination partner of TNF inhibitors and tocilizumab: what is reasonable from an immunological viewpoint?].
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Rheumatoid arthritis and cardiovascular disease: an update on treatment issues.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Humans; Methotrexate; Risk Factors | 2013 |
The new European League Against Rheumatism/American College of Rheumatology diagnostic criteria for rheumatoid arthritis: how are they performing?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sensitivity and Specificity | 2013 |
Leprosy in a rheumatology setting: a challenging mimic to expose.
Topics: Adult; Aged; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Diagnostic Errors; False Positive Reactions; Female; Humans; Leprosy; Male; Methotrexate; Middle Aged; Retrospective Studies; Rheumatoid Factor; Rheumatology; Symptom Assessment | 2013 |
Severe Guillain-Barré syndrome in a patient receiving anti-TNF therapy. Consequence or coincidence. A case-based review.
Topics: Adalimumab; Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Campylobacter Infections; Female; Guillain-Barre Syndrome; Humans; Immunoglobulins, Intravenous; Methotrexate; Middle Aged; Respiration, Artificial; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Abdominal Pain; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Gastrointestinal Diseases; Hematologic Diseases; Humans; Leucovorin; Methotrexate; Nausea; Vomiting | 2013 |
Etanercept for the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor | 2013 |
Potential food-drug interactions in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Calcineurin; Calcineurin Inhibitors; Citrus paradisi; Enzyme Inhibitors; Folic Acid; Food-Drug Interactions; Fruit; Humans; Isoniazid; Methotrexate; Risk Factors; Seafood | 2013 |
Methotrexate in rheumatoid arthritis: a quarter century of development.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2013 |
Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis.
Topics: Antibodies, Blocking; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Methotrexate; Patient Education as Topic; Rituximab; Tumor Necrosis Factor-alpha | 2013 |
A meta-analysis of the role of p38 mitogen-activated protein kinase inhibitors in patients with active rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; p38 Mitogen-Activated Protein Kinases; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2013 |
Biologic and oral disease-modifying antirheumatic drug monotherapy in rheumatoid arthritis.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Contraindications; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Tumor Necrosis Factor-alpha | 2013 |
The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Immunomodulation; Inflammation; Inflammatory Bowel Diseases; Methotrexate; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
[Paradigm shift and future perspectives in rheumatoid arthritis].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Diagnosis; Humans; Methotrexate; Practice Guidelines as Topic | 2013 |
[Pharmacological management of rheumatoid arthritis: the state of the art and the future perspective].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Europe; Humans; Japan; Methotrexate; Practice Guidelines as Topic; Tumor Necrosis Factor-alpha; United States | 2013 |
[DMARDs (disease-modifying antirheumatic drugs)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Humans; Japan; Methotrexate; Sulfasalazine; Tacrolimus | 2013 |
[Efficacy and adverse reactions of the TNFalpha inhibitor infliximab in rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
[Etanercept].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Japan; Methotrexate; Receptors, Tumor Necrosis Factor | 2013 |
[Personalized drug therapy-directed clinical pharmacology research based on genetic polymorphisms and pharmacokinetics analysis].
Topics: Anticoagulants; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Drug Therapy, Combination; Gene Frequency; Humans; Maintenance Chemotherapy; Methotrexate; Pharmacokinetics; Polymorphism, Genetic; Precision Medicine; Replication Protein C; Thromboembolism; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin | 2013 |
Cardiovascular risk in rheumatoid arthritis: how to lower the risk?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors; Risk Reduction Behavior; Tumor Necrosis Factor-alpha | 2013 |
C reactive protein may not be reliable as a marker of severe bacterial infection in patients receiving tocilizumab.
Topics: Aged; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Humans; Knee Joint; Male; Methotrexate; Prednisolone; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Staphylococcal Infections; Sulfasalazine; Treatment Outcome | 2013 |
Therapeutic drug monitoring in rheumatic diseases: utile or futile?
Topics: Allopurinol; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Gout Suppressants; Humans; Methotrexate; Rheumatic Diseases; Tumor Necrosis Factor-alpha | 2014 |
Update on methotrexate as the anchor drug for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Time Factors; Treatment Outcome | 2013 |
Efficacy and safety of methotrexate in combination with other non-biologic disease-modifying antirheumatic drugs (DMARDs) in treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Time Factors; Treatment Outcome | 2013 |
The role of concomitant methotrexate in biologic therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Time Factors; Treatment Outcome | 2013 |
Parenteral methotrexate for the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections; Methotrexate; Treatment Outcome | 2013 |
Epstein-Barr virus-positive oral ulceration simulating Hodgkin lymphoma in a patient treated with methotrexate: case report and review of the literature.
Topics: Aged, 80 and over; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Epstein-Barr Virus Infections; Female; Follow-Up Studies; Gingival Diseases; Hodgkin Disease; Humans; Immunosuppressive Agents; Methotrexate; Oral Ulcer; Prednisone | 2014 |
Intravenous tocilizumab: a review of its use in adults with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Intravenous; Methotrexate; Treatment Outcome | 2014 |
Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP-Binding Cassette Transporters; Biological Transport; Folate Receptor 2; Humans; Methotrexate; Organic Anion Transporters; Tissue Distribution | 2014 |
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Evidence-Based Medicine; Folic Acid; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Review Literature as Topic | 2013 |
The comparison of effects of biologic agents on rheumatoid arthritis damage progression is biased by period of enrollment: data from a systematic review and meta-analysis.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Bias; Biological Products; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin G; Infliximab; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Rituximab; Time Factors; Treatment Outcome | 2014 |
Methotrexate-induced pneumonitis: heterogeneity of bronchoalveolar lavage and differences between cancer and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; CD4-CD8 Ratio; Humans; Lung; Lymphocytosis; Methotrexate; Neoplasms; Neutrophils; Pneumonia | 2014 |
Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Humans; Methotrexate; Piperidines; Practice Guidelines as Topic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Practice Guidelines as Topic | 2013 |
Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Methotrexate; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Radiological outcomes in randomized controlled trials on biologic therapies for rheumatoid arthritis: a narrative review.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Disease Progression; Etanercept; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Inflammation; Infliximab; Magnetic Resonance Imaging; Methotrexate; Polyethylene Glycols; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Rituximab; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
Predictive factors of response to biological disease modifying antirheumatic drugs: towards personalized medicine.
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Body Mass Index; Cytokines; Female; Humans; Immunoconjugates; Male; Methotrexate; Phenotype; Precision Medicine; Remission Induction; Rituximab; Sex Factors; Smoking; Treatment Outcome | 2014 |
Genetic and epigenetic predictors of responsiveness to treatment in RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Epigenesis, Genetic; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
What drives the comparative effectiveness of biologics vs. methotrexate in rheumatoid arthritis? Meta-regression and graphical inspection of suspected clinical factors.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Randomized Controlled Trials as Topic; Regression Analysis; Time Factors; Treatment Outcome | 2014 |
Hypereosinophilia and seroconversion of rheumatoid arthritis.
Topics: Adalimumab; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Female; Humans; Hypereosinophilic Syndrome; Methotrexate; Rheumatoid Factor | 2014 |
Methotrexate in rheumatoid arthritis: optimizing therapy among different formulations. Current and emerging paradigms.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Drug Administration Routes; Humans; Infusions, Parenteral; Injections, Intramuscular; Injections, Subcutaneous; Methotrexate; Quality of Life | 2014 |
Induction therapy with combination TNF inhibitor and methotrexate in early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: a meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2014 |
Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic | 2014 |
Efficacy and safety of certolizumab pegol in rheumatoid arthritis: meeting rheumatologists' requirements in routine clinical practice.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Immunoglobulin Fab Fragments; Methotrexate; Molecular Targeted Therapy; Polyethylene Glycols; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2014 |
In brief: otrexup--a single-use auto-injector formulation of methotrexate.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Humans; Injections, Subcutaneous; Methotrexate; Psoriasis; Self Administration | 2014 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Leucovorin; Male; Methotrexate | 2014 |
Methotrexate and lung disease in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate; Risk | 2014 |
RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Determinism; Humans; Methotrexate; Observational Studies as Topic; Pharmacogenetics; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Treatment Outcome | 2014 |
Increased cardiovascular risk in patients with rheumatoid arthritis: an overview.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Belgium; Cardiovascular Diseases; Drug Therapy, Combination; Endothelium, Vascular; Evidence-Based Medicine; Humans; Methotrexate; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis.
Topics: Arthritis, Rheumatoid; Asian People; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic | 2014 |
Rheumatoid myositis leading to acute lower extremity compartment syndrome: a case-based review.
Topics: Arthritis, Rheumatoid; Biopsy; Blood Sedimentation; Compartment Syndromes; Creatine Kinase; Edema; Female; Humans; Immunosuppressive Agents; Inflammation; Leg; Leukocytes, Mononuclear; Methotrexate; Middle Aged; Muscle, Skeletal; Muscular Atrophy; Myositis; Prednisone; Rheumatoid Factor | 2015 |
Risk of breast cancer and total malignancies in rheumatoid arthritis patients undergoing TNF-α antagonist therapy: a meta-analysis of randomized control trials.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Certolizumab Pegol; Etanercept; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Methotrexate; Neoplasms; Odds Ratio; Polyethylene Glycols; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
Methotrexate for treating rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Medication Adherence; Methotrexate; Randomized Controlled Trials as Topic | 2014 |
Health Assessment Questionnaire disability progression in early rheumatoid arthritis: systematic review and analysis of two inception cohorts.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Disability Evaluation; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Patient Outcome Assessment; Prospective Studies; Surveys and Questionnaires; Treatment Outcome; United Kingdom; Young Adult | 2014 |
Methotrexate-associated lymphoproliferative disorders of the tongue developing in patients with rheumatoid arthritis: a report of 2 cases and a review.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Tongue Diseases | 2015 |
New autoinjector technology for the delivery of subcutaneous methotrexate in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Injections, Subcutaneous; Methotrexate | 2014 |
Etanercept-associated transient bone marrow aplasia: a review of the literature and pathogenetic mechanisms.
Topics: Anemia, Aplastic; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bone Marrow; Etanercept; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Hydroxychloroquine; Immunoglobulin G; Methotrexate; Middle Aged; Pancytopenia; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2014 |
Comparative efficacy of biologics as monotherapy and in combination with methotrexate on patient reported outcomes (PROs) in rheumatoid arthritis patients with an inadequate response to conventional DMARDs--a systematic review and network meta-analysis.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Certolizumab Pegol; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Patient Outcome Assessment; Polyethylene Glycols; Quality of Life; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2014 |
Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infections; Longitudinal Studies; Male; Methotrexate; Middle Aged; Piperidines; Prevalence; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome; Young Adult | 2014 |
Systematic review of tofacitinib: a new drug for the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2014 |
Therapeutic options after treatment failure in rheumatoid arthritis or spondyloarthritides.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prognosis; Remission Induction; Severity of Illness Index; Spondylarthritis; Time Factors; Treatment Failure | 2014 |
Laboratory biomarkers for guiding therapy with methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate | 2015 |
Methotrexate for the treatment of rheumatoid arthritis in the biologic era: still an "anchor" drug?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Design; Drug Therapy, Combination; Methotrexate; Treatment Outcome | 2014 |
Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Retrospective Studies; Risk Factors; Treatment Outcome | 2014 |
[Diagnosis and treatment of rheumatoid arthritis].
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; C-Reactive Protein; Combined Modality Therapy; Cost of Illness; Drug Therapy, Combination; Exercise Therapy; Female; Follow-Up Studies; Humans; Methotrexate; Pain Measurement; Prednisolone | 2014 |
The past versus the present, 1980-2004: reduction of mean initial low-dose, long-term glucocorticoid therapy in rheumatoid arthritis from 10.3 to 3.6 mg/day, concomitant with early methotrexate, with long-term effectiveness and safety of less than 5 mg/da
Topics: Anti-Arrhythmia Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Glucocorticoids; Humans; Longitudinal Studies; Male; Methotrexate; Surveys and Questionnaires; Treatment Outcome | 2015 |
Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Janus Kinases; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoglobulin Fab Fragments; Methotrexate; Polyethylene Glycols; Randomized Controlled Trials as Topic | 2014 |
Methotrexate: a gold standard for treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Routes; Drug Delivery Systems; Drug Therapy, Combination; Humans; Methotrexate | 2014 |
Optimizing the expediency of TNFi in rheumatoid arthritis: offering a TNFi holiday in patients having reached low-disease activity in the maintenance phase.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Humans; Methotrexate; Neoplasm, Residual; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha; Withholding Treatment | 2014 |
Intensive intervention can lead to a treatment holiday from biological DMARDs in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Medication Therapy Management; Methotrexate; Patient Acuity; Remission Induction; Withholding Treatment | 2014 |
Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Carrier Proteins; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Methotrexate; Pharmacogenetics; Prognosis; Signal Transduction | 2014 |
Methotrexate revisited: considerations for subcutaneous administration in RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate | 2015 |
The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Psoriasis; Risk Factors; Tumor Necrosis Factor-alpha | 2015 |
Combination conventional DMARDs compared to biologicals: what is the evidence?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Radiography; Randomized Controlled Trials as Topic | 2015 |
Rituximab for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Publication Bias; Randomized Controlled Trials as Topic; Rituximab | 2015 |
Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Adhesion; Cell Movement; Cell Proliferation; Dendritic Cells; Gene Expression Regulation; Humans; Immune System; Inflammation; Joints; Methotrexate; Monocytes; RANK Ligand; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2015 |
Treatment of pseudo Felty's syndrome: Is there a place for rituximab?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Female; Humans; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Retrospective Studies; Rituximab | 2015 |
Rheumatoid arthritis: Perioperative management of biologics and DMARDs.
Topics: Abatacept; Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Biological Products; Etanercept; Humans; Hydroxychloroquine; Methotrexate; Perioperative Care; Prosthesis-Related Infections; Rituximab | 2015 |
[Management of rheumatoid arthritis medications and pregnancy].
Topics: Abatacept; Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Etanercept; Female; Fertility; Humans; Infliximab; Methotrexate; Milk, Human; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Risk; Time Factors; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Iguratimod for the treatment of rheumatoid arthritis in Japan.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Japan; Methotrexate; Sulfonamides | 2015 |
Cardiovascular effects of methotrexate in rheumatoid arthritis revisited.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate | 2015 |
Comparative Efficacy of Novel DMARDs as Monotherapy and in Combination with Methotrexate in Rheumatoid Arthritis Patients with Inadequate Response to Conventional DMARDs: A Network Meta-Analysis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic | 2015 |
Epstein-Barr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Multiple Myeloma | 2015 |
Comparative efficacy and safety of tofacitinib, with or without methotrexate, in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2015 |
Anti-arthritic agents: progress and potential.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cartilage; Drugs, Investigational; Glucocorticoids; Humans; Joints; Methotrexate; Osteoarthritis; Pain | 2015 |
[Risk of serious infection in patients with rheumatoid arthritis].
Topics: Age Factors; Arthritis, Rheumatoid; Biological Products; Comorbidity; Diabetes Mellitus; Female; Glucocorticoids; Humans; Incidence; Infections; Lung Diseases; Male; Methotrexate; Risk; Risk Factors; Severity of Illness Index; Sex Factors; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Ascites and other incidental findings revealing undiagnosed systemic rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Ascites; Humans; Incidental Findings; Liver Function Tests; Male; Methotrexate; Naproxen; Pericardial Effusion; Pleural Effusion; Prednisolone; Referral and Consultation; Rheumatoid Factor; Rheumatoid Nodule; Treatment Outcome | 2015 |
Updated systematic review and meta-analysis of randomized controlled trials comparing low- versus high-dose rituximab for rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Rituximab; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Young Adult | 2015 |
Advances in the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Early Diagnosis; Glucocorticoids; Humans; Methotrexate; Radiography; Remission Induction; Severity of Illness Index | 2015 |
Rheumatoid Nodules.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Lung Neoplasms; Methotrexate; Multiple Pulmonary Nodules; Rheumatoid Nodule; Skin | 2015 |
Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside.
Topics: Arthritis, Rheumatoid; Humans; Inflammation; Janus Kinase 1; Janus Kinase 3; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT1 Transcription Factor; Translational Research, Biomedical; Tumor Necrosis Factor-alpha | 2015 |
Education for patients with rheumatoid arthritis in Latin America and the Caribbean.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Caribbean Region; Disease Management; Humans; Internet; Latin America; Methotrexate; Patient Education as Topic; Program Evaluation | 2015 |
A case of breathlessness.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dyspnea; Female; Glucocorticoids; Humans; Hyperbaric Oxygenation; Lung Diseases, Interstitial; Methotrexate; Methylprednisolone; Middle Aged; Tomography, X-Ray Computed | 2015 |
Key findings from studies of methotrexate tapering and withdrawal in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction | 2015 |
Efficacy of etanercept for treating the active rheumatoid arthritis: an updated meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Etanercept; Humans; Methotrexate; Odds Ratio; Remission Induction; Time Factors; Treatment Outcome | 2016 |
Flare Rate in Patients with Rheumatoid Arthritis in Low Disease Activity or Remission When Tapering or Stopping Synthetic or Biologic DMARD: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Randomized Controlled Trials as Topic; Remission Induction; Retrospective Studies; Risk Assessment; Severity of Illness Index; Withholding Treatment | 2015 |
[Update on Current Care Guidelines. Rheumatoid Arthritis (RA)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Decision Making; Exercise Therapy; Glucocorticoids; Humans; Hydroxychloroquine; Methotrexate; Practice Guidelines as Topic; Referral and Consultation; Sulfasalazine | 2015 |
Protective effects of methotrexate against ischemic cardiovascular disorders in patients treated for rheumatoid arthritis or psoriasis: novel therapeutic insights coming from a meta-analysis of the literature data.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Psoriasis | 2016 |
Optimizing Methotrexate Treatment in Rheumatoid Arthritis: The Case for Subcutaneous Methotrexate Prior to Biologics.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Injections, Subcutaneous; Methotrexate | 2015 |
Efficacy and safety of combination therapy for preventing bone damage in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Observational Studies as Topic; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Subcutaneous administration of methotrexate at high doses makes a better performance in the treatment of rheumatoid arthritis compared with oral administration of methotrexate: A systematic review and meta-analysis.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2016 |
Evaluation of golimumab for the treatment of patients with active rheumatoid arthritis.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Methotrexate; Mice; Mice, Transgenic; Remission Induction; Tumor Necrosis Factor-alpha | 2016 |
Methotrexate and Rheumatoid Arthritis: Current Evidence Regarding Subcutaneous Versus Oral Routes of Administration.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Injections, Subcutaneous; Methotrexate | 2016 |
Inadequate response or intolerability to oral methotrexate: Is it optimal to switch to subcutaneous methotrexate prior to considering therapy with biologics?
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Substitution; Humans; Injections, Subcutaneous; Methotrexate; Retreatment; Treatment Outcome | 2016 |
[Optimal Treatment for Rheumatoid Arthritis with Companion Diagnostics].
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Gene-Environment Interaction; HLA-DRB1 Chains; Humans; Infliximab; Matrix Metalloproteinase 3; Methotrexate; Peptides, Cyclic; Pharmacogenetics; Precision Medicine | 2015 |
Preoperative Use of Methotrexate and the Risk of Early Postoperative Complications in Patients with Inflammatory Bowel Disease.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Colitis, Ulcerative; Crohn Disease; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Middle Aged; Odds Ratio; Postoperative Complications; Preoperative Period; Retrospective Studies; Sepsis; Tumor Necrosis Factor-alpha; Young Adult | 2016 |
Methotrexate dosage as a source of bias in biological trials in rheumatoid arthritis: a systematic review.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Bias; Biological Products; Clinical Trials as Topic; Humans; Injections; Methotrexate | 2016 |
Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Regression Analysis; Treatment Outcome | 2016 |
Withdrawal of biologic agents in rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Infliximab; Methotrexate; Randomized Controlled Trials as Topic; Remission Induction | 2016 |
Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for the treatment of rheumatoid arthritis not previously treated with disease-modifying antirheumatic drugs and after the failure of conventional disease-modifyin
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost-Benefit Analysis; Etanercept; Humans; Infliximab; Methotrexate; Network Meta-Analysis; Quality-Adjusted Life Years | 2016 |
Update on Therapeutic Approaches for Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Disease Models, Animal; Humans; Methotrexate; Pain Management; Synovial Membrane; T-Lymphocytes | 2016 |
The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Bone Resorption; Humans; Immune System; Methotrexate; Molecular Targeted Therapy; Osteoclasts | 2016 |
Safety and Efficacy of Methotrexate in Psoriasis: A Meta-Analysis of Published Trials.
Topics: Arthritis, Rheumatoid; Dermatologic Agents; Humans; Immunosuppressive Agents; Methotrexate; Nausea; Opportunistic Infections; Oral Ulcer; Patient Safety; Psoriasis; Risk; Treatment Outcome | 2016 |
Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Etanercept; Humans; Infliximab; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rituximab | 2016 |
The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Gene Frequency; Genetic Association Studies; Genotype; Humans; Methotrexate; Polymorphism, Genetic; Reduced Folate Carrier Protein; Treatment Outcome | 2016 |
Pharmacologic Therapies for Rheumatologic and Autoimmune Conditions.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Biological Products; Colchicine; Gout Suppressants; Humans; Immunosuppressive Agents; Methotrexate | 2016 |
Challenges and treatment options for rheumatoid arthritis during pregnancy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Sulfasalazine; Treatment Outcome | 2016 |
Landmark papers on the discovery of methotrexate for the treatment of rheumatoid arthritis and other systemic inflammatory rheumatic diseases: a fascinating story.
Topics: Animals; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Discovery; History, 20th Century; Humans; Methotrexate; Rheumatology; Treatment Outcome | 2016 |
[Guidelines for the management of rheumatoid arthritis].
Topics: Abatacept; Algorithms; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Substitution; Drug Therapy, Combination; Humans; Japan; Methotrexate; Piperidines; Practice Guidelines as Topic; Pyrimidines; Pyrroles | 2016 |
[MTX].
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2016 |
[IL-6 blockade].
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Discovery; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Molecular Targeted Therapy; Receptors, Interleukin-6; Remission Induction; Treatment Outcome | 2016 |
[Abatacept].
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; CTLA-4 Antigen; Disease Progression; Drug Therapy, Combination; Humans; Lymphocyte Activation; Methotrexate; Molecular Targeted Therapy; Product Surveillance, Postmarketing; T-Lymphocytes | 2016 |
[Prevention of surgical site infection for orthopaedic surgery in rheumatoid arthritis].
Topics: Abatacept; Antibiotic Prophylaxis; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Arthroplasty, Replacement; Biological Products; Humans; Methotrexate; Nasal Cavity; Oral Hygiene; Orthopedic Procedures; Perioperative Care; Prednisolone; Risk Factors; Surgical Wound Infection; Withholding Treatment | 2016 |
[Rheumatoid arthritis and malignancy].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Colorectal Neoplasms; Female; Humans; Lung Neoplasms; Lymphoma; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Risk Factors | 2016 |
[Cardiovascular diseases in rheumatoid arthritis].
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Etanercept; Humans; Incidence; Methotrexate; Molecular Targeted Therapy; Morbidity; Prognosis; Quality of Life | 2016 |
Efficacy and safety of methotrexate plus certolizumab pegol or placebo in active rheumatoid arthritis : Meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Certolizumab Pegol; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2017 |
[Methotrexate].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Evidence-Based Medicine; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome | 2016 |
Association of the ATIC 347 C/G polymorphism with responsiveness to and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Association Studies; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Multienzyme Complexes; Nucleotide Deaminases; Pharmacogenetics; Polymorphism, Genetic; Treatment Outcome | 2016 |
Factors Associated With Sustained Remission in Rheumatoid Arthritis in Patients Treated With Anti-Tumor Necrosis Factor.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prospective Studies; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2016 |
[Management of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Evidence-Based Medicine; Humans; Methotrexate; Patient Care Management; Physical Therapy Modalities; Treatment Outcome | 2016 |
Methotrexate and lung disease in rheumatoid arthritis.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Humans; Incidence; Inflammatory Bowel Diseases; Lung Diseases; Lung Diseases, Interstitial; Male; Methotrexate; Prevalence; Psoriasis | 2017 |
Comparative effectiveness of biologics for the management of rheumatoid arthritis: systematic review and network meta-analysis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Comparative Effectiveness Research; Drug Therapy, Combination; Humans; Methotrexate; Network Meta-Analysis; Quality of Life; Randomized Controlled Trials as Topic; Receptors, Interleukin-6 | 2017 |
Therapeutic management of patients with rheumatoid arthritis and associated interstitial lung disease: case report and literature review.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Disease Progression; Follow-Up Studies; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome | 2017 |
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Adhesion Molecules; Cytokines; Eicosanoids; Folic Acid Antagonists; Humans; Metalloproteases; Methotrexate; Methylation; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2016 |
Adherence and Persistence with Methotrexate in Rheumatoid Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Medication Adherence; Methotrexate | 2016 |
Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA).
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Disease Progression; Etanercept; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Rituximab; Treatment Failure | 2016 |
Stopping tumour necrosis factor-targeted biological DMARDs in rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Deprescriptions; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Infliximab; Methotrexate; Radiography; Remission Induction; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2016 |
Tofacitinib Versus Biologic Treatments in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors: Results From a Network Meta-analysis.
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Male; Methotrexate; Network Meta-Analysis; Piperidines; Pyrimidines; Pyrroles; Rituximab; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Low-Dose Methotrexate (LD-MTX) in Rheumatology Practice - A Most Widely Misunderstood Drug.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate; Rheumatology | 2016 |
Vasculitis and inflammatory arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Glucocorticoids; Humans; Incidence; Methotrexate; Rituximab; Vasculitis | 2016 |
Efficacy of triple association methotrexate, sulfasalazine and hydroxychloroquine in early treatment of rheumatoid arthritis with insufficient response to methotrexate: Meta-analysis of randomized controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Pain Measurement; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome | 2017 |
Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Association Studies; Humans; Methotrexate; Polymorphism, Single Nucleotide; Treatment Outcome | 2017 |
Meta-Regression of a Dose-Response Relationship of Methotrexate in Mono- and Combination Therapy in Disease-Modifying Antirheumatic Drug-Naive Early Rheumatoid Arthritis Patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Time Factors; Treatment Outcome | 2017 |
Treatment strategy of elderly rheumatoid arthritis.
Topics: Activities of Daily Living; Administration, Oral; Age of Onset; Aged; Aged, 80 and over; Analgesics; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Combined Modality Therapy; Drug Therapy, Combination; Glucocorticoids; Humans; Infliximab; Joints; Methotrexate; Orthopedic Procedures | 2016 |
Treatment of rheumatoid arthritis with combination of methotrexate and Tripterygium wilfordii: A meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Plant Extracts; Randomized Controlled Trials as Topic; Tripterygium | 2017 |
[New options for the practice : Update S1/S2 guidelines on rheumatoid arthritis?]
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Decision-Making; Evidence-Based Medicine; Forecasting; Germany; Humans; Methotrexate; Outcome Assessment, Health Care; Practice Guidelines as Topic; Rheumatology; Treatment Outcome | 2017 |
[Serious complications during treatment with methotrexate: also in chronic low-dosage use].
Topics: Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Renal Insufficiency | 2017 |
Relative risk of and determinants for adverse events of methotrexate prescribed at a low dose: a systematic review and meta-analysis of randomized placebo-controlled trials.
Topics: Anti-Asthmatic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Asthma; Dermatologic Agents; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Randomized Controlled Trials as Topic; Risk Factors | 2017 |
The Cost-effectiveness of Sequences of Biological Disease-modifying Antirheumatic Drug Treatment in England for Patients with Rheumatoid Arthritis Who Can Tolerate Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; England; Humans; Methotrexate | 2017 |
Safety and efficacy of ocrelizumab in rheumatoid arthritis patients with an inadequate response to methotrexate or tumor necrosis factor inhibitors: a systematic review and meta-analysis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chi-Square Distribution; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Humans; Injection Site Reaction; Methotrexate; Odds Ratio; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Glucocorticoids; Humans; Janus Kinases; Methotrexate; Patient Participation; Protein Kinase Inhibitors; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Treatment Outcome | 2017 |
Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Female; Folic Acid; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Treatment Outcome; White People | 2017 |
Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Disease Progression; Humans; Methotrexate; Neoplasms; Network Meta-Analysis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Failure | 2017 |
Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Biomarkers; Ferredoxin-NADP Reductase; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Pharmacogenetics; Polymorphism, Single Nucleotide; Replication Protein C | 2017 |
[Paradigm shift in the treatment of rheumatoid arthritis by biologics].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Design; Etanercept; Humans; Immunoglobulin G; Inflammation; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Rituximab; Tumor Necrosis Factor-alpha | 2008 |
Approaches to the treatment of early rheumatoid arthritis with disease-modifying antirheumatic drugs.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Quality of Life; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
[The pulmonological manifestations of rheumatoid arthritis].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Coccidioidomycosis; Etanercept; Humans; Immunocompromised Host; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Infliximab; Lung Diseases; Methotrexate; Pneumonia; Pulmonary Edema; Quality of Life; Receptors, Tumor Necrosis Factor; Respiratory Tract Infections; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha | 2008 |
[Daily practice using the guidelines for prevention and treatment of osteoporosis. The effects of anti-TNF therapy on bone and joint manifestations in rheumatoid arthritis].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Hepatitis C virus-related arthritis.
Topics: Adrenal Cortex Hormones; Ankle; Antibodies, Viral; Arthralgia; Arthritis, Infectious; Arthritis, Rheumatoid; Chronic Disease; Cryoglobulinemia; Cyclooxygenase 2 Inhibitors; Cyclosporine; Hepacivirus; Hepatitis C; Humans; Hydroxychloroquine; Interferon-alpha; Methotrexate; Penicillamine; Purpura | 2008 |
Treatment with infliximab plus methotrexate improves anemia in patients with rheumatoid arthritis independent of improvement in other clinical outcome measures-a pooled analysis from three large, multicenter, double-blind, randomized clinical trials.
Topics: Anemia; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Hemoglobins; Humans; Infliximab; Male; Methotrexate; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Regression Analysis; Treatment Outcome | 2009 |
Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Eruptions; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Immunosuppressive Agents; Leucovorin; Liver Diseases; Methotrexate; Psoriasis; Randomized Controlled Trials as Topic | 2009 |
DMARDS and infections in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infections; Isoxazoles; Leflunomide; Methotrexate; Risk Factors | 2008 |
[Adalimumab (Humira)--efficacy in rheumatoid arthritis treatment with particular reference to working ability].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Employment; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2008 |
Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Routes; Drug Administration Schedule; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2009 |
The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunotherapy; Methotrexate; Mice; NADPH Oxidases; Neutrophils; Oxidative Stress; Polymorphism, Genetic; Rats; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2009 |
Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Humans; Infections; Long-Term Care; Methotrexate; Neoplasms; Pneumonia; Risk Factors | 2009 |
Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens.
Topics: Administration, Oral; Adult; Age Factors; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome | 2008 |
[Trends in therapeutic guidelines for rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Humans; Infliximab; Magnetic Resonance Imaging; Matrix Metalloproteinase 3; Methotrexate; Palpation; Peptides, Cyclic; Practice Guidelines as Topic; Remission Induction; Tumor Necrosis Factor-alpha | 2008 |
[Antirheumatic agents for treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Pharmacogenetics; Randomized Controlled Trials as Topic; Remission Induction; Sulfasalazine; Time Factors | 2008 |
[Recent topics on new biological agents for treatment of rheumatoid arthritis].
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Surface; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Cytokines; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Randomized Controlled Trials as Topic; Rituximab; T-Lymphocytes | 2008 |
[New ways in the management of rheumatoid arthritis in Hungary].
Topics: Abatacept; Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Azathioprine; Chloroquine; Cyclophosphamide; Cyclosporine; Diagnosis, Differential; Early Diagnosis; Etanercept; Humans; Hungary; Immunoconjugates; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prognosis; Receptors, Tumor Necrosis Factor; Rituximab; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
Modulation of T-cell co-stimulation in rheumatoid arthritis: clinical experience with abatacept.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Humans; Immunoconjugates; Methotrexate; Pain; Quality of Life; Radiography; Sleep; Stimulation, Chemical; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2009 |
[A novel treatment option in rheumatoid arthritis: abatacept, a selective modulator of T-cell co-stimulation].
Topics: Abatacept; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Immunoconjugates; Infliximab; Lymphocyte Activation; Methotrexate; Randomized Controlled Trials as Topic; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2009 |
[Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Disease Progression; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Methotrexate; Penicillamine; Radiography; Randomized Controlled Trials as Topic; Sulfasalazine; Tacrolimus | 2009 |
[Recent progress in clinical trials for rheumatic diseases].
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Design; Drug Therapy, Combination; Humans; Immunoconjugates; Interleukin-6; Intracellular Signaling Peptides and Proteins; Janus Kinase 3; Lupus Erythematosus, Systemic; Methotrexate; Protein-Tyrosine Kinases; Rheumatic Diseases; Rituximab; Signal Transduction; Syk Kinase; Tumor Necrosis Factor-alpha | 2009 |
The BeSt story: on strategy trials in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Cyclosporine; Drug Therapy, Combination; Humans; Hydroxychloroquine; Infliximab; Methotrexate; Prednisolone; Sulfasalazine | 2009 |
Clinical expression of leflunomide-induced pneumonitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Pneumonia; Retrospective Studies; Tomography, X-Ray Computed | 2009 |
Long-term outcomes of rheumatoid arthritis.
Topics: Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Clinical Trials as Topic; Humans; Methotrexate; Time Factors; Treatment Outcome; Work Capacity Evaluation | 2009 |
Recent concepts in the inhibition of radiographic progression with biologics.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Humans; Methotrexate; Radiography; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
An update on methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pharmacogenetics; Rheumatic Diseases | 2009 |
[Indications for and use of biologics in early rheumatoid arthritis based on the evidence].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Immunoglobulin G; Infliximab; Japan; Methotrexate; Receptors, Tumor Necrosis Factor; Remission Induction; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
[Methotrexate-associated lymphoproliferative disorder presenting as oral ulcers in a patient with rheumatoid arthritis].
Topics: Aged; Antigens, CD; Antigens, Neoplasm; Arthritis, Rheumatoid; Biomarkers, Tumor; Epstein-Barr Virus Infections; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunoglobulin kappa-Chains; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Oral Ulcer; Remission Induction | 2009 |
Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Comorbidity; Drug Administration Schedule; Humans; Immunosuppressive Agents; Methotrexate; Risk | 2009 |
Rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Treatment Outcome | 2007 |
Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naive to both drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome | 2009 |
[Present status and problems in biologics for treatment of rheumatoid arthritis in Japan].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Drug Design; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Immunoglobulin G; Infliximab; Interleukin-6; Japan; Methotrexate; Practice Guidelines as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
Can rheumatoid arthritis responsiveness to methotrexate and biologics be predicted?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Humans; Immunologic Factors; Methotrexate; Pharmacogenetics; Prognosis; Treatment Outcome | 2009 |
Golimumab: in the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Injections, Subcutaneous; Methotrexate; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2009 |
Management of RA medications in pregnant patients.
Topics: Abatacept; Acetaminophen; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Contraindications; Cyclosporine; Female; Gestational Age; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Methotrexate; Pregnancy; Pregnancy Complications; Rituximab; Sulfasalazine; Young Adult | 2009 |
Clinical implications of understanding radiographic findings in relation to clinical outcomes in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Biological Products; Clinical Competence; Comprehension; Disability Evaluation; Drug Monitoring; Humans; Joints; Methotrexate; Predictive Value of Tests; Severity of Illness Index; Synovitis; Time Factors; Treatment Outcome | 2009 |
Mechanisms underlying methotrexate-induced pulmonary toxicity.
Topics: Arthritis, Rheumatoid; Enzyme Activation; Genotype; Humans; Inactivation, Metabolic; Lung Diseases; Methotrexate; Models, Biological; p38 Mitogen-Activated Protein Kinases | 2009 |
A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Rheumatoid Factor; Treatment Outcome | 2009 |
Denosumab for joints and bones.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Bone Density Conservation Agents; Clinical Trials as Topic; Denosumab; Drug Therapy, Combination; Female; Humans; Joints; Methotrexate; Middle Aged; Osteoclasts; Osteoporosis, Postmenopausal; RANK Ligand | 2009 |
Therapeutic options for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Remission Induction | 2009 |
[Biochemical markers of bone turnover. New aspect. Therapy of rheumatoid arthritis for bone metabolic marker].
Topics: Alkaline Phosphatase; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Collagen Type I; Drug Therapy, Combination; Humans; Infliximab; Interleukin-6; Methotrexate; Peptides; Tumor Necrosis Factor-alpha | 2009 |
[Rituximab treatment of rheumatoid arthritis: new evidence].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Isoxazoles; Leflunomide; Methotrexate; Rituximab | 2009 |
[Rheumatoid arthritis].
Topics: Adult; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; C-Reactive Protein; Diagnosis, Differential; Edema; Female; Glucocorticoids; Hand; Humans; Methotrexate; Prednisolone | 2009 |
[Visceral leishmaniasis infection in a rheumatoid arthritis patient treated with adalimumab: a case description and literature review].
Topics: Adalimumab; Aged; Animals; Animals, Domestic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Bone Marrow; Cats; Disease Reservoirs; Dog Diseases; Dogs; Drug Therapy, Combination; Duodenum; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Latent Tuberculosis; Leishmaniasis, Visceral; Methotrexate; Naproxen; Prednisone | 2010 |
A systematic review and meta-analysis of the efficacy and safety of etanercept for treating rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2009 |
Response of elderly patients with rheumatoid arthritis to methotrexate or TNF inhibitors compared with younger patients.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Logistic Models; Methotrexate; Odds Ratio; Receptors, Tumor Necrosis Factor; Rituximab; Treatment Outcome | 2009 |
Certolizumab pegol: in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Certolizumab Pegol; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Methotrexate; Polyethylene Glycols; Randomized Controlled Trials as Topic | 2009 |
[Pulmonary tuberculosis associated to adalimumab: a study of 3 cases].
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antitubercular Agents; Arthritis, Rheumatoid; Disease Susceptibility; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Opportunistic Infections; Spondylitis, Ankylosing; Tuberculosis, Miliary; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha | 2010 |
A systematic comparison of combination DMARD therapy and tumour necrosis inhibitor therapy with methotrexate in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Immunosuppressive Agents; Insulin Resistance; Lipids; Methotrexate | 2010 |
Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Publication Bias | 2010 |
Golimumab for rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2010 |
Evaluation of abatacept in biologic-naïve patients with active rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Treatment Outcome | 2010 |
Patient-tailored therapy in rheumatoid arthritis: an editorial review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Clinical Protocols; Drug Design; Humans; Immunologic Factors; Methotrexate; Physician-Patient Relations; Rheumatic Diseases; Tumor Necrosis Factor-alpha | 2010 |
Methotrexate--how does it really work?
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Methotrexate; Polyamines | 2010 |
Predictors for remission in rheumatoid arthritis patients: A systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Haplotypes; Humans; Interleukin-2; Male; Methotrexate; Patient Selection; Prognosis; Registries; Rheumatoid Factor; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
[Immunomodulatory therapy improves quality of life with rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunologic Factors; Immunosuppressive Agents; Methotrexate; Patient Satisfaction; Psychometrics; Quality of Life; Randomized Controlled Trials as Topic; Reproducibility of Results; Surveys and Questionnaires | 2010 |
Leg ulceration in rheumatoid arthritis--an underreported multicausal complication with considerable morbidity: analysis of thirty-six patients and review of the literature.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Etoricoxib; Female; Gram-Positive Bacterial Infections; Humans; Isoxazoles; Leflunomide; Leg; Leg Ulcer; Male; Methotrexate; Middle Aged; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Pyridines; Retrospective Studies; Risk Factors; Sulfones | 2010 |
Golimumab and malignancies: true or false association?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Neoplasms | 2011 |
Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2010 |
Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.
Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Carbon; Cytochromes c; Folic Acid; Humans; Kinetics; Methotrexate; Mitochondria; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Recombinant Proteins; Substrate Specificity | 2010 |
[Rheumatoid arthritis, methothrexate, and pulmonary fibrosis: which evidences?].
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Humans; Liver Cirrhosis; Methotrexate; Pulmonary Fibrosis; Smoking | 2010 |
[Lipid profile and cardiovascular risk in patients with rheumatoid arthritis: Effect of the disease and of drug therapy].
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Chronic Disease; Dyslipidemias; Female; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Lipid Metabolism; Lipids; Lipoproteins; Male; Methotrexate; Risk Factors | 2010 |
Efficacy of initial methotrexate monotherapy versus combination therapy with a biological agent in early rheumatoid arthritis: a meta-analysis of clinical and radiographic remission.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index; Treatment Outcome | 2010 |
Strategies after the failure of the first anti-tumor necrosis factor alpha agent in rheumatoid arthritis.
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoconjugates; Infliximab; Methotrexate; Randomized Controlled Trials as Topic; Rituximab; Tumor Necrosis Factor-alpha | 2010 |
Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Databases, Factual; Drug Interactions; Hematologic Diseases; Humans; Methotrexate; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
Golimumab for rheumatoid arthritis: a systematic review.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Health Status; Humans; Methotrexate; Randomized Controlled Trials as Topic; Recovery of Function; Remission Induction; Severity of Illness Index; Treatment Outcome | 2010 |
Predictors of clinical response and radiographic progression in patients with rheumatoid arthritis treated with methotrexate monotherapy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Databases, Factual; Disease Progression; Female; Humans; Male; Methotrexate; Predictive Value of Tests; Radiography | 2010 |
[Secondary osteoporosis UPDATE. Rheumatoid arthritis and bone damage: trends in treatment].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Bone Density Conservation Agents; Bone Remodeling; Denosumab; Diphosphonates; Glucocorticoids; Humans; Methotrexate; Osteoclasts; Osteoporosis; RANK Ligand; Synovial Membrane; Tumor Necrosis Factor-alpha | 2010 |
Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Evidence-Based Medicine; Female; Humans; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2010 |
Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Methotrexate; Opportunistic Infections; Practice Guidelines as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Rheumatoid arthritis: choice of antirheumatic treatment. Methotrexate first.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Rituximab; Tumor Necrosis Factor-alpha | 2010 |
Perioperative management of the patient with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Cervical Vertebrae; Clinical Laboratory Techniques; Glucocorticoids; Humans; Immobilization; Methotrexate; Penicillamine; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Radiography; Spinal Diseases; Tumor Necrosis Factor-alpha; Venous Thrombosis | 2010 |
The efficacy and safety of rituximab for the treatment of active rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Bibliographic; Drug Resistance; Drug Therapy, Combination; Health Status; Humans; Methotrexate; Randomized Controlled Trials as Topic; Recovery of Function; Registries; Rituximab; Treatment Outcome | 2011 |
Development of two primary malignant melanomas after treatment with adalimumab: a case report and review of the possible link between biological therapy with TNF-alpha antagonists and melanocytic proliferation.
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Humans; Leg; Male; Melanocytes; Melanoma; Methotrexate; Scalp; Skin Neoplasms; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
New-onset psoriasis associated with etanercept therapy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Prednisolone; Psoriasis; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Sulfasalazine; Tumor Necrosis Factor-alpha | 2010 |
Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Evidence-Based Medicine; Hematologic Diseases; Humans; Liver; Methotrexate; Patient Preference; Practice Guidelines as Topic; Rheumatology | 2010 |
Native albumin for targeted drug delivery.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Carriers; Drug Compounding; Drug Delivery Systems; Fluorescent Dyes; Humans; Methotrexate; Mice; Rats; Serum Albumin | 2010 |
Tocilizumab for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hypercholesterolemia; Methotrexate; Randomized Controlled Trials as Topic | 2010 |
[The goal for the treatment of rheumatoid arthritis should be remission].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Finland; Glucocorticoids; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine | 2010 |
The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: methodological report phase I.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Early Diagnosis; Epidemiologic Methods; Evidence-Based Medicine; Female; Humans; International Cooperation; Male; Methotrexate; Middle Aged; Patient Selection | 2010 |
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Health Status; Humans; Janus Kinase 3; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2010 |
Cardiovascular disease in rheumatoid arthritis: disease and treatment interactions and their implications on treatment decisions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Risk Factors | 2010 |
RAPID and FAST4WARD trials: certolizumab pegol for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Certolizumab Pegol; Clinical Trials as Topic; Disease Progression; Drug Resistance; Humans; Immunoglobulin Fab Fragments; Methotrexate; Polyethylene Glycols; Quality of Life; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Certolizumab pegol in the treatment of rheumatoid arthritis: a comprehensive review of its clinical efficacy and safety.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Humans; Immunoglobulin Fab Fragments; Methotrexate; Polyethylene Glycols; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Tocilizumab for rheumatoid arthritis: a Cochrane systematic review.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Humans; Methotrexate; Placebos; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2011 |
Tocilizumab for the treatment of rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Protein Binding; Receptors, Interleukin-6; Respiratory Tract Infections; Treatment Outcome | 2010 |
Certolizumab pegol: a new biologic targeting rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Clinical Protocols; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Methotrexate; Polyethylene Glycols; Practice Guidelines as Topic; Tumor Necrosis Factor-alpha | 2010 |
Fractures of the proximal tibia associated with longterm use of methotrexate: 3 case reports and a review of literature.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Tibial Fractures | 2010 |
Cutaneous nodules in patients with rheumatoid arthritis: a case report and review of literatures.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Hepatitis, Autoimmune; Humans; Immune System; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Rheumatoid Nodule; Skin; Skin Diseases | 2011 |
Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome | 2011 |
Safety profile of abatacept in rheumatoid arthritis: a review.
Topics: Abatacept; Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate | 2010 |
Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
The treatment of rheumatoid arthritis during pregnancy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Methotrexate; Pregnancy; Pregnancy Complications; Sulfasalazine; Tumor Necrosis Factor-alpha | 2011 |
Golimumab: Review of the efficacy and tolerability of a recently approved tumor necrosis factor-α inhibitor.
Topics: Antibodies, Monoclonal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Databases, Factual; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Approval; Drug Therapy, Combination; Humans; Immunologic Factors; Methotrexate; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; United States; United States Food and Drug Administration | 2010 |
When to initiate and discontinue biologic treatments for rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Immunologic Factors; Methotrexate; Prognosis; Treatment Failure; Tumor Necrosis Factor-alpha | 2011 |
[Rheumatoid arthritis: milestones in classification and treatment].
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Drug Resistance; Evidence-Based Medicine; Germany; Humans; Methotrexate; National Health Programs; Practice Guidelines as Topic | 2011 |
Tocilizumab: is there life beyond anti-TNF blockade?
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Humans; Methotrexate; Remission Induction; Tumor Necrosis Factor-alpha | 2011 |
Treatment of early rheumatoid arthritis: concepts in management.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Early Diagnosis; Humans; Methotrexate; Treatment Outcome | 2011 |
Treatment strategies in recent onset rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Prednisone; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
[Interstitial mycosis fungoid: a rare variant of mycosis fungoids. Two cases].
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Clobetasol; Female; Humans; Immunophenotyping; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Neoplasm Recurrence, Local; PUVA Therapy; Skin Neoplasms; T-Lymphocyte Subsets | 2011 |
Tumor necrosis factor therapy and the risk of serious infection and malignancy in patients with early rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Communicable Diseases; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Randomized Controlled Trials as Topic; Risk; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Methotrexate versus leflunomide in rheumatoid arthritis: what is new in 2011?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha | 2011 |
Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Intercellular Adhesion Molecule-1; Isoxazoles; Leflunomide; Liver; Lung Diseases; Lymphocyte Function-Associated Antigen-1; Methotrexate; Neoplasms; Pharmacogenetics; Rituximab; Tumor Necrosis Factor-alpha | 2011 |
Optimizing methotrexate therapy in rheumatoid arthritis: a systematic literature review.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Infusions, Subcutaneous; Methotrexate; Treatment Outcome | 2011 |
[Effectiveness of biological treatments based on ACR70 response in rheumatoid arthritis: indirect comparison and meta-regression using Bayes-model].
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Therapy; Biomarkers; Certolizumab Pegol; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Mathematical Computing; Methotrexate; Odds Ratio; Polyethylene Glycols; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Regression Analysis; Rituximab; Severity of Illness Index; Time Factors; Treatment Outcome | 2011 |
Distinct effects of anti-tumor necrosis factor combined therapy on TH1/TH2 balance in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; Drug Therapy, Combination; Homeostasis; Humans; Methotrexate; Th1 Cells; Th2 Cells; Tumor Necrosis Factor-alpha | 2011 |
Golimumab and immunogenicity? 2010 and beyond.
Topics: Antibodies, Antinuclear; Antibodies, Monoclonal; Antibody Formation; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA; Humans; Immunosuppressive Agents; Methotrexate; Spondylitis, Ankylosing | 2011 |
Understanding emerging treatment paradigms in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clindamycin; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Remission Induction; Tumor Necrosis Factor-alpha | 2011 |
Cardiovascular risk factors in inflammatory arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Hydroxychloroquine; Methotrexate; Risk Factors | 2011 |
[Is it possible to compare different studies on efficacy of biologicals in patients with rheumatoid arthritis? : mixed treatment comparison as a new tool for indirect comparison of clinical studies].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Drug Approval; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Changes in patient characteristics in anti-tumour necrosis factor clinical trials for rheumatoid arthritis: results of an analysis of the literature over the past 16 years.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Patient Selection; Randomized Controlled Trials as Topic; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2011 |
[Is methotrexate nephrotoxic? Dose-dependency, comorbidities and comedication].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Metabolic Clearance Rate; Methotrexate; Renal Insufficiency; Risk Factors | 2011 |
[Standardization of methotrexate administration in routine rheumatological practice].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Rheumatology | 2011 |
[Tocilizumab in rheumatoid arthritis].
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Disease Susceptibility; Drug Therapy, Combination; Humans; Hypercholesterolemia; Infections; Methotrexate; Multicenter Studies as Topic; Receptors, Interleukin-6 | 2011 |
Rheumatoid arthritis near remission: clinical rather than laboratory inflammation is associated with radiographic progression.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Indirect comparison of biological treatments in refractory rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials, Phase III as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Humans; Immunoglobulins; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Recombinant Proteins | 2012 |
Methotrexate for rheumatoid arthritis patients who are on hemodialysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Humans; Kidney Failure, Chronic; Methotrexate; Pancytopenia; Renal Dialysis; Tumor Necrosis Factor-alpha; Withholding Treatment | 2011 |
[For parenteral gold therapy in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Evidence-Based Medicine; Gold Compounds; Humans; Infusions, Intravenous; Methotrexate; Remission Induction; Treatment Outcome | 2011 |
[Cardiovascular comorbidity and its risk factors in rheumatoid arthritis].
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Cardiovascular Diseases; Cause of Death; Comorbidity; Drug Therapy, Combination; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Methotrexate; Middle Aged; Peptides, Cyclic; Practice Guidelines as Topic; Prognosis; Rheumatoid Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2011 |
[Rheumatoid arthritis: a cardiovascular disease?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors; Stroke; Tumor Necrosis Factor-alpha | 2012 |
Cutaneous melanoma in patients in treatment with biological therapy: review of the literature and case report.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biological Therapy; Humans; Male; Melanoma; Methotrexate; Skin Neoplasms | 2011 |
MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms.
Topics: Arthritis, Rheumatoid; Biomarkers, Pharmacological; Genetic Association Studies; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide | 2013 |
A mixed treatment comparison of the efficacy of anti-TNF agents in rheumatoid arthritis for methotrexate non-responders demonstrates differences between treatments: a Bayesian approach.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Evidence-Based Medicine; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Failure; Tumor Necrosis Factor-alpha | 2012 |
Leukoencephalopathy induced by low-dose methotrexate in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dexamethasone; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Methotrexate | 2011 |
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Administration Schedule; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Remission Induction; Sjogren's Syndrome; Sulfasalazine; Teratogens; Tumor Necrosis Factor-alpha | 2011 |
To switch or not to switch after a poor response to a TNFα blocker? It is not only a matter of ACR20 OR ACR50.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Discovery; Drug Substitution; Humans; Immunotherapy; Methotrexate; Treatment Failure; Tumor Necrosis Factor-alpha | 2012 |
Rheumatoid arthritis and anaesthesia.
Topics: Airway Management; Anesthesia; Arthritis, Rheumatoid; Autoantibodies; Biological Products; Cytokines; Humans; Methotrexate | 2011 |
Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis).
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspirin; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Spondylarthritis; Spondylitis, Ankylosing | 2011 |
Cardiovascular safety of biologic therapies for the treatment of RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Comorbidity; Databases, Factual; Humans; Methotrexate; Registries; Risk Factors; Tumor Necrosis Factor-alpha | 2011 |
What is the outcome of RA in 2011 and can we predict it?
Topics: Age of Onset; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Autoimmunity; Cardiovascular Diseases; Comorbidity; Disease Progression; Female; Humans; Joints; Lung Diseases; Male; Methotrexate; Middle Aged; Prognosis; Risk Factors; Sex Factors; Smoking; Survival Rate; Treatment Outcome | 2011 |
The use of conventional disease-modifying anti-rheumatic drugs in established RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Monitoring; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Randomized Controlled Trials as Topic; Time Factors | 2011 |
B-cell therapies in established rheumatoid arthritis.
Topics: Agammaglobulinemia; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infections; Male; Methotrexate; Randomized Controlled Trials as Topic; Rituximab; Treatment Failure | 2011 |
Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Outcome Assessment, Health Care; Remission Induction; Severity of Illness Index; Surveys and Questionnaires | 2011 |
[Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 1. Methotrexate].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2011 |
Biological therapy for rheumatoid arthritis: where are we now?
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoconjugates; Immunotherapy; Methotrexate; Molecular Targeted Therapy; Prognosis; Randomized Controlled Trials as Topic; Remission Induction; Rituximab; Tumor Necrosis Factor-alpha | 2012 |
[Rheumatoid arthritis - target-oriented treatment focussing remission].
Topics: Ankle Joint; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Clinical Trials as Topic; Disease Progression; Humans; Immunosuppressive Agents; Methotrexate; Molecular Targeted Therapy; Patient Participation; Prognosis; Treatment Outcome; Wrist Joint | 2012 |
[Recent progress in the treatment of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Denosumab; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin-6; Methotrexate; Molecular Targeted Therapy; Piperidines; Pyrimidines; Pyrroles; RANK Ligand; Receptors, Tumor Necrosis Factor; Reference Standards; Remission Induction; Tumor Necrosis Factor-alpha | 2012 |
[ Bone and cartilage destruction in RA and its intervention. Disease-modifying antirheumatic drugs].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Cartilage; Clinical Trials as Topic; Cysteine; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Sulfasalazine; Tacrolimus | 2012 |
[Bone and cartilage destruction in RA and its intervention. Biological agents].
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infliximab; Joints; Methotrexate; Molecular Targeted Therapy; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome | 2012 |
[Off-label therapy of rheumatoid arthritis and spondyloarthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Dose-Response Relationship, Drug; Drug Approval; Drug Costs; Drug Therapy, Combination; Germany; Humans; Insurance, Pharmaceutical Services; Isoxazoles; Leflunomide; Methotrexate; National Health Programs; Off-Label Use; Reimbursement Mechanisms; Spondylarthritis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Indirect treatment comparison of abatacept with methotrexate versus other biologic agents for active rheumatoid arthritis despite methotrexate therapy in the United kingdom.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Female; Health Status; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Recovery of Function; Treatment Failure; Treatment Outcome | 2012 |
Optimal use of non-biologic therapy in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Europe; Glucocorticoids; Humans; Methotrexate; Practice Guidelines as Topic; Severity of Illness Index; Time Factors | 2012 |
Use of abatacept in rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoconjugates; Methotrexate; Radiography; Tumor Necrosis Factor-alpha | 2012 |
Cost utility of tumour necrosis factor-α inhibitors for rheumatoid arthritis: an application of Bayesian methods for evidence synthesis in a Markov model.
Topics: Arthritis, Rheumatoid; Bayes Theorem; Cost-Benefit Analysis; Drug Therapy, Combination; Etanercept; Health Resources; Humans; Immunoglobulin G; Immunosuppressive Agents; Markov Chains; Methotrexate; Models, Economic; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2012 |
Lessons for the use of non-biologic anchor treatments for rheumatoid arthritis in the era of biologic therapies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prednisone; Treatment Outcome | 2012 |
Biologic monotherapy as initial treatment in patients with early rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate; Receptors, Interleukin-6; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Developing an effective treatment algorithm for rheumatoid arthritis.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Delivery Systems; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Severity of Illness Index | 2012 |
My treatment approach to rheumatoid arthritis.
Topics: Abatacept; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Comorbidity; Diagnosis, Differential; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Immunoconjugates; Isoxazoles; Joints; Leflunomide; Methotrexate; Prednisone; Prognosis; Quality of Life; Randomized Controlled Trials as Topic; Referral and Consultation; Remission Induction; Rituximab; Severity of Illness Index; Sulfasalazine; Synovitis; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
[Anemia in patients with rheumatoid arthritis].
Topics: Anemia; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Chronic Disease; Diagnosis, Differential; Drug Therapy, Combination; Hemoglobins; Humans; Methotrexate | 2012 |
Current treatments of rheumatoid arthritis: from the 'NinJa' registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Humans; Japan; Methotrexate; Registries; Treatment Outcome | 2012 |
Progress toward personalized treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Precision Medicine; Treatment Outcome | 2012 |
Iguratimod: a new disease-modifying antirheumatic drug.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine; Sulfonamides | 2012 |
Meta-analysis of clinical and radiological efficacy of biologics in rheumatoid arthritis patients naive or inadequately responsive to methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Humans; Methotrexate; Middle Aged; Radiography; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Meta-analysis suggests that intensive non-biological combination therapy with step-down prednisolone (COBRA strategy) may also 'disconnect' disease activity and damage in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Joints; Methotrexate; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine | 2013 |
Cardiovascular risk in rheumatoid arthritis: pathogenesis, diagnosis, and management.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Autoimmune Diseases; Cardiovascular Diseases; Carotid Arteries; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Methotrexate; Pulse Wave Analysis; Regional Blood Flow; Risk Factors; Stem Cells; Tunica Intima; Tunica Media; Vascular Calcification; Vascular Stiffness; Vasodilation | 2012 |
Evolution of treatment for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Disability Evaluation; Disease Progression; Humans; Methotrexate; Treatment Outcome | 2012 |
ACR/EULAR 2010 rheumatoid arthritis classification criteria.
Topics: Acute-Phase Proteins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Europe; Humans; Joints; Methotrexate; Societies, Medical; United States | 2012 |
Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Polymorphism, Genetic; Retrospective Studies; Risk Factors | 2013 |
Corticosteroids as disease modifying drugs in rheumatoid arthritis treatment.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2012 |
The effect of autoimmune arthritis treatment strategies on regulatory T-cell dynamics.
Topics: Abatacept; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Biological Factors; Child; Humans; Immunoconjugates; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Methotrexate; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 2013 |
A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis.
Topics: Animals; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Methotrexate; Neoplasms | 2013 |
Felty's syndrome without rheumatoid arthritis?
Topics: Adrenal Cortex Hormones; Agranulocytosis; Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Splenomegaly | 2013 |
Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Precision Medicine; Treatment Outcome | 2013 |
Methotrexate pharmacogenetics in rheumatoid arthritis: a status report.
Topics: Arthritis, Rheumatoid; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Pharmacogenetics; Polymorphism, Single Nucleotide | 2013 |
Infliximab for the treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Randomized Controlled Trials as Topic | 2002 |
Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: case report and review of the literature.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, B-Cell; Methotrexate; Remission, Spontaneous | 2002 |
Monitoring methotrexate hepatic toxicity in rheumatoid arthritis: is it time to update the guidelines?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Monitoring; Hospitals, Special; Humans; Methotrexate; Practice Guidelines as Topic; Rheumatology | 2002 |
Not yet time to change the guidelines for monitoring methotrexate liver toxicity: they have served us well.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Monitoring; Humans; Methotrexate; Practice Guidelines as Topic; Rheumatology | 2002 |
Anakinra.
Topics: Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Radiography; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Recombinant Proteins; Sialoglycoproteins | 2002 |
Examining the efficacy of biologic therapy: are there real differences?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Sensitivity and Specificity; Sialoglycoproteins; Treatment Outcome | 2002 |
Methotrexate: vital new information about a middle aged drug.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydroxychloroquine; Liver; Methotrexate; Treatment Outcome | 2002 |
Genetic influences on rheumatoid arthritis in African Americans.
Topics: Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Black People; Genes, MHC Class II; Genetic Markers; Genetics, Population; Humans; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; United States; White People | 2002 |
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Child; Child, Preschool; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunologic Factors; Injections, Subcutaneous; Methotrexate; Pharmacokinetics; Radiography; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Treatment Outcome | 2002 |
[Gastrointestinal side effects in the therapy of rheumatologic diseases].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Etanercept; Gastrointestinal Diseases; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Rheumatic Diseases; Stomach Ulcer; Sulfasalazine; Tumor Necrosis Factor-alpha | 2002 |
Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Drug Resistance; Humans; Methotrexate; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Polymorphism, Genetic | 2003 |
[Recommendations of the Deutschen Gesellschaft für Rheumatologie on therapy of rheumatoid arthritis with the interleukin-1-receptor-antagonist Akakinra (KINERET)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Critical Pathways; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Sialoglycoproteins | 2002 |
[Methotrexate for the treatment of rheumatoid arthritis in Japan--much more still remains to be resolved].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate | 2002 |
[Clinical implication of cyclosporin for rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Resistance, Multiple; Humans; Immunosuppressive Agents; Methotrexate | 2002 |
[Combination therapy of disease-modifying antirheumatic drugs(DMARDs) in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Penicillamine; Sulfasalazine | 2002 |
[Efficacy of leflunomide].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Blind Method; Humans; Isoxazoles; Leflunomide; Liver Diseases; Methotrexate; Mice; Sulfasalazine | 2002 |
[Infliximab in the treatment of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Humans; Infliximab; Methotrexate | 2002 |
[Adalimumab].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Tumor Necrosis Factor-alpha | 2002 |
[Etanercept].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Etanercept; Humans; Immunoglobulin G; Infections; Methotrexate; Receptors, Tumor Necrosis Factor | 2002 |
[Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Sialoglycoproteins | 2002 |
Leflunomide for treating rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine | 2003 |
[Evidence-based treatment of methotrexate-resistant rheumatoid arthritis. Cytokine antagonists].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Drug Administration Schedule; Drug Resistance; Etanercept; Evidence-Based Medicine; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methotrexate; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 2003 |
Methotrexate: first-line or second-line immunomodulator?
Topics: Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Humans; Immunosuppressive Agents; Liver Cirrhosis; Methotrexate | 2003 |
[Pharmacological profile of anti-human TNF alpha monoclonal antibody, infliximab (Remicade)].
Topics: Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Clinical Trials as Topic; Crohn Disease; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Tumor Necrosis Factor-alpha | 2003 |
Is there still a role for traditional disease-modifying antirheumatic drugs (DMARDs) in rheumatoid arthritis?
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Long-Term Care; Male; Methotrexate; Organogold Compounds; Prognosis; Research; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2003 |
[Interleukin-1 receptor antagonists in the treatment rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Sialoglycoproteins | 2002 |
[Combination therapy in rheumatoid arthritis].
Topics: Adjuvants, Immunologic; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine | 2003 |
[Gold preparations in therapy of rheumatoid and psoriatic arthritis].
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Auranofin; Clinical Trials as Topic; Controlled Clinical Trials as Topic; Double-Blind Method; Gold Sodium Thiomalate; Humans; Methotrexate; Placebos; Time Factors | 2003 |
Sarcoid arthritis: a review of clinical features, pathology and therapy.
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chronic Disease; Environment; Genetic Predisposition to Disease; Granuloma; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Sarcoidosis; Tumor Necrosis Factor-alpha | 2003 |
[Kidney involvement in rheumatoid arthritis].
Topics: Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Autopsy; Biopsy; Cyclosporine; Glomerulonephritis; Humans; Kidney; Kidney Diseases; Methotrexate; Nephritis, Interstitial; Penicillamine; Time Factors | 2003 |
Methotrexate intolerance in elderly patients with rheumatoid arthritis: what are the alternatives?
Topics: Aged; Aging; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Humans; Metabolic Diseases; Methotrexate | 2003 |
Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate; Patient Selection; Pneumonia | 2004 |
[Methotrexate therapy in rheumatologic diseases--an update].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Rheumatic Diseases | 2003 |
[Current concepts of pharmacotherapy in rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Cyclophosphamide; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Feasibility Studies; Female; Glucocorticoids; Humans; Ibuprofen; Immunosuppressive Agents; Isoxazoles; Ketoprofen; Leflunomide; Male; Methotrexate; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Sulfasalazine; Time Factors | 2003 |
Comparison of the efficacy of the tumour necrosis factor alpha blocking agents adalimumab, etanercept, and infliximab when added to methotrexate in patients with active rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunologic Factors; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
Rheumatoid arthritis in 2003: where are we now with treatment?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
[Rheumatology 2003-part I: research news concerning pathogenesis, epidemiology, diagnosis, and therapy of chronic inflammatory joint diseases].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cells, Cultured; Clinical Trials as Topic; Diagnosis, Differential; Disease Models, Animal; Female; HLA Antigens; Humans; Infliximab; Methotrexate; Middle Aged; Placebos; Polymorphism, Genetic; Pregnancy; Prognosis; Quality of Life; Randomized Controlled Trials as Topic; Rats; Spondylarthropathies; Spondylitis, Ankylosing; Time Factors | 2003 |
Guidelines for monitoring of methotrexate therapy: "evidence-based medicine" outside of clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Evidence-Based Medicine; Humans; Methotrexate; Practice Guidelines as Topic | 2003 |
Etanercept for the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor | 2003 |
[Drug therapy of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Retrospective Studies; Time Factors | 2003 |
Newer approaches to the treatment of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor | 2003 |
Methotrexate and psoriasis in the era of new biologic agents.
Topics: Arthritis, Rheumatoid; Combined Modality Therapy; Dermatologic Agents; Humans; Methotrexate; Practice Guidelines as Topic; Psoriasis | 2004 |
Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 2004 |
Improvement in health utility among patients with rheumatoid arthritis treated with adalimumab (a human anti-TNF monoclonal antibody) plus methotrexate.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2004 |
Adalimumab: a review of its use in rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Area Under Curve; Arthritis, Rheumatoid; Biological Availability; Drug Therapy, Combination; Half-Life; Humans; Methotrexate; Quality of Life; Randomized Controlled Trials as Topic; Tissue Distribution; Treatment Outcome | 2004 |
[Collagen diseases and rheumatic diseases].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Drug Therapy, Combination; Genes, T-Cell Receptor delta; Humans; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Lymphocytes; Methotrexate; Prednisolone; Prognosis; Tumor Necrosis Factor-alpha | 2004 |
[Methotrexate for treatment of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Cytokines; Drug Therapy, Combination; Female; Growth Substances; Humans; Infliximab; Male; Methotrexate | 2004 |
Appropriate and effective management of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation; Antirheumatic Agents; Arthritis, Rheumatoid; CTLA-4 Antigen; Humans; Methotrexate; Practice Guidelines as Topic; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
The impact of new biologicals in the treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Etanercept; Humans; Immunoglobulin G; Immunologic Factors; Immunosuppressive Agents; Infliximab; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 2004 |
Leflunomide.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Monitoring; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Joints; Leflunomide; Liver; Methotrexate; Models, Animal | 2004 |
Infliximab treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
The use of anakinra, an interleukin-1 receptor antagonist, in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methotrexate; Receptors, Interleukin; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Cytotoxic T-lymphocyte antigen 4-immunoglobulin in rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immune System; Immunoconjugates; Methotrexate | 2004 |
[Diagnosis and therapy of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty; Cyclooxygenase Inhibitors; Cyclosporine; Drug Therapy, Combination; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Methotrexate; Rheumatoid Factor; Sulfasalazine | 2004 |
Leflunomide in the treatment of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Dihydroorotate Dehydrogenase; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Oxidoreductases Acting on CH-CH Group Donors; Protein-Tyrosine Kinases | 2004 |
The soluble tumor necrosis factor receptor etanercept: a new strategy for the treatment of autoimmune rheumatic disease.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Quality of Life; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Rheumatoid arthritis: more aggressive approach improves outlook.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Complementary Therapies; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Time Factors | 2004 |
Anakinra: an inhibitor of IL-1 for the treatment of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Susceptibility; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infections; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Sialoglycoproteins; Treatment Outcome | 2004 |
[Internist's therapy of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Diagnosis, Differential; Disease Progression; Guidelines as Topic; Humans; Internal Medicine; Methotrexate; Patient Care Management; Practice Patterns, Physicians'; Severity of Illness Index; Treatment Outcome | 2004 |
The use of methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Pain Measurement; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
Multiple faces of rheumatoid arthritis: diagnostic and therapeutic algorithms.
Topics: Algorithms; Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Radiography; Treatment Outcome | 2004 |
Considerations with the use of biological therapy in the treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Clinical Trials as Topic; Combined Modality Therapy; Cytokines; Demyelinating Diseases; Disease Progression; Drug Therapy, Combination; Erythema; Heart Failure; Humans; Immunocompromised Host; Immunologic Factors; Interleukin-1; Methotrexate; Neoplasms; Opportunistic Infections; Tuberculosis; Tumor Necrosis Factor-alpha | 2004 |
Rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine | 2003 |
Durability and rapidity of response to anakinra in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Randomized Controlled Trials as Topic; Sialoglycoproteins | 2004 |
Etanercept: a pharmacoeconomic review of its use in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Drug Costs; Drug Resistance; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 2004 |
Two inhibitors of DNA-synthesis lead to inhibition of cytokine production via a different mechanism.
Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Cytokines; DNA; Dose-Response Relationship, Drug; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocytes; Methotrexate; Mycophenolic Acid; Nucleic Acid Synthesis Inhibitors | 2004 |
Antimetabolites in the treatment of arthritis: current status of the use of antimetabolites.
Topics: Antimetabolites; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Methotrexate; Time Factors | 2004 |
Damage control in rheumatoid arthritis. Hard-hitting, early treatment is crucial to curbing joint destruction.
Topics: Arthritis, Rheumatoid; Azathioprine; Disease Progression; Humans; Hydroxychloroquine; Immunologic Factors; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2004 |
Cost-effectiveness estimates reported for tumor necrosis factor blocking agents in rheumatoid arthritis refractory to methotrexate--a brief summary.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Cost-Benefit Analysis; Humans; Methotrexate; Sweden; Tumor Necrosis Factor-alpha; United Kingdom; United States | 2005 |
Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Comorbidity; Databases, Factual; Drug Synergism; Drug Therapy, Combination; Female; Florida; Folic Acid; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Incidence; Male; Medical Records Systems, Computerized; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk; Vascular Diseases; Veterans | 2005 |
B cell-directed therapy in rheumatoid arthritis--clinical experience.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Arthritis, Rheumatoid; B-Lymphocytes; Drug Therapy, Combination; Humans; Methotrexate; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Rituximab; Treatment Outcome | 2005 |
Etanercept in arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Treatment Outcome | 2005 |
The 'alphabet' of rheumatoid arthritis treatment.
Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arachidonic Acid; Arthritis, Rheumatoid; Cyclooxygenase 1; Cyclooxygenase 2; Drug Monitoring; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoxazoles; Leflunomide; Membrane Proteins; Methotrexate; Nurse's Role; Nursing Assessment; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor; Rituximab; Sialoglycoproteins; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2004 |
[Respiratory complications of new treatments for rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; Methotrexate; Respiratory Tract Infections; Tumor Necrosis Factor-alpha | 2004 |
[Immunological and serological tests for diagnosis of rheumatoid arthritis: MMP-3].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Etanercept; Humans; Immunoglobulin G; Infliximab; Matrix Metalloproteinase 3; Methotrexate; Prognosis; Receptors, Tumor Necrosis Factor; Tissue Inhibitor of Metalloproteinases | 2005 |
[Lesson from ACR guidelines for management of RA].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Practice Guidelines as Topic; Receptors, Tumor Necrosis Factor; Rheumatology; Societies, Medical; United States | 2005 |
[Guidelines for RA therapies].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Japan; Leflunomide; Methotrexate; Orthopedic Procedures; Practice Guidelines as Topic; Prednisolone | 2005 |
[Strategy for the management of RA patients].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Patient Care Management; Patient Care Team; Prognosis | 2005 |
[Disease modifying anti-rheumatic drugs (DMARDs): an overview].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzopyrans; Cysteine; Evidence-Based Medicine; Gold Sodium Thiomalate; Humans; Isoxazoles; Leflunomide; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Sulfonamides | 2005 |
[Methotrexate for therapy of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Folic Acid; Humans; Immunoglobulin G; Infliximab; Lung Diseases, Interstitial; Methotrexate; Receptors, Tumor Necrosis Factor | 2005 |
[Infliximab for therapy of rheumatoid arthritis].
Topics: Anaphylaxis; Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Mice; Tumor Necrosis Factor-alpha | 2005 |
[Anakinra for therapy of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Sialoglycoproteins | 2005 |
[Combination drug therapy in rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2005 |
[Adverse effects of DMARDs in treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Hematologic Diseases; Humans; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Reproduction; Sulfasalazine | 2005 |
[Tailor-made medicine and genomic drug discovery in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arylamine N-Acetyltransferase; Drug Design; Genome, Human; Haplotypes; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Sulfasalazine | 2005 |
Anakinra: review of recombinant human interleukin-I receptor antagonist in the treatment of rheumatoid arthritis.
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Receptors, Interleukin-1; Sialoglycoproteins | 2004 |
Rheumatoid arthritis: an update.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2005 |
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome | 2005 |
Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate | 2005 |
[Secondary amyloidosis in patients with rheumatoid arthritis].
Topics: Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Diagnosis, Differential; Dialysis; Glucocorticoids; Hemodiafiltration; Humans; Immunosuppressive Agents; Methotrexate; Prognosis; Serum Amyloid A Protein; Serum Amyloid P-Component | 2005 |
[Methotrexate].
Topics: Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Folic Acid; Humans; Immunosuppressive Agents; Methotrexate; Prognosis | 2005 |
[Anti-TNF-alpha antibody].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Practice Guidelines as Topic; Tumor Necrosis Factor-alpha | 2005 |
[CTLA4-Ig].
Topics: Abatacept; Animals; Antigens, CD; Arthritis, Rheumatoid; B7-1 Antigen; B7-2 Antigen; CD28 Antigens; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunoconjugates; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Membrane Glycoproteins; Methotrexate; Signal Transduction; T-Lymphocytes | 2005 |
[A soluble TNF-alpha receptor agent: etanercept].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Interleukin-1; Interleukin-6; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2005 |
Spontaneous remission of marginal zone B cell lymphoma in a patient with seropositive rheumatoid arthritis after discontinuation of infliximab-methotrexate treatment.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Lymphoma, B-Cell; Methotrexate; Middle Aged; Neoplasm Regression, Spontaneous; Paranasal Sinus Neoplasms | 2005 |
Adalimumab for treating rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2005 |
B-cell lymphoma of the larynx in a patient with rheumatoid arthritis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Humans; Laryngeal Neoplasms; Lymphoma, B-Cell; Male; Methotrexate; Prednisone; Tomography, X-Ray Computed; Vincristine | 2005 |
Low-dose oral methotrexate for maintaining Crohn's disease remission: where we stand.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Crohn Disease; Drug Administration Schedule; Humans; Immunosuppressive Agents; Intestinal Absorption; Methotrexate; Randomized Controlled Trials as Topic; Remission Induction | 2005 |
[Modern antirheumatic pharmacotherapy. Low molecular weight substances vs. biologicals].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Patient Selection; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tumor Necrosis Factor-alpha | 2005 |
Incidence of lymphoma in a large primary care derived cohort of cases of inflammatory polyarthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; England; Epidemiologic Methods; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2006 |
[Modern treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Resistance; Exercise; Glucocorticoids; Humans; Methotrexate | 2005 |
[Biologic therapy with anti-TNFα in rheumathoid arthritis].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Radiography; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
[T-large granular lymphocyte leukaemia. An important differential diagnosis to Felty's syndrome].
Topics: Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Felty Syndrome; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, T-Cell; Methotrexate; Vidarabine | 2006 |
[Liver damage in methotrexate-treated patients. When liver biopsy is necessary in the follow-up?].
Topics: Arthritis, Rheumatoid; Biopsy, Needle; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Psoriasis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index | 2005 |
Pharmacogenetics of therapies in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Humans; Immunologic Factors; Methotrexate; Pharmacogenetics; Sulfasalazine | 2005 |
Adalimumab for rheumatoid arthritis?
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2006 |
A European perspective on the challenges of managing psoriasis.
Topics: Arthritis, Rheumatoid; Chronic Disease; Humans; Immunosuppressive Agents; Methotrexate; Psoriasis; Stress, Psychological | 2006 |
The treatment of psoriasis and psoriatic arthritis: an interdisciplinary approach.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Etanercept; Etretinate; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Keratolytic Agents; Methotrexate; Psoriasis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2006 |
[Adverse events in rheumatoid arthritis patient with etanercept therapy: the appearance of osteomalacia].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Osteomalacia; Receptors, Tumor Necrosis Factor | 2005 |
[Armentarium and strategies for the treatment of rheumatoid arthritis].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Family Practice; Humans; Hydroxychloroquine; Meta-Analysis as Topic; Methotrexate; Rheumatology; Risk Assessment; Sulfasalazine; Tumor Necrosis Factor Inhibitors | 2005 |
B cell-targeted therapy for rheumatoid arthritis: an update on the evidence.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Rituximab | 2006 |
Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: report of two cases and review of the literature.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis | 2006 |
Rituximab (Rituxan) for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Costs; Humans; Methotrexate; Randomized Controlled Trials as Topic; Rituximab | 2006 |
Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2006 |
[Methotrexate therapy for rheumatism and collagen diseases].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Collagen Diseases; Folic Acid; Humans; Methotrexate | 2002 |
Cytotoxic and immunologic effects of methotrexate in psoriasis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; DNA; Epidermal Cells; Epidermis; Graft vs Host Disease; Humans; Immune System; Methotrexate; Mice; Psoriasis | 1990 |
Methotrexate pharmacogenomics.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2006 |
An unusual presentation of methotrexate-induced B-cell lymphoma of the metacarpophalangeal joint: a case report and literature review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemotherapy, Adjuvant; Humans; Joint Capsule; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Radiotherapy, Adjuvant | 2006 |
Medical therapy: where are we now?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome | 2006 |
[Treatment of rheumatoid arthritis with adalimumab. Results from a Cochrane review].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2006 |
[Link between rheumatoid arthritis and cancer].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Epstein-Barr Virus Infections; Female; Hodgkin Disease; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasms; Risk Factors; Tumor Necrosis Factor-alpha | 2006 |
[Biologicals in the treatment of rheumatic diseases].
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Child; Clinical Trials, Phase II as Topic; Cohort Studies; Collagen Diseases; Drug Therapy, Combination; Etanercept; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Immunoconjugates; Immunoglobulin G; Infliximab; Methotrexate; Placebos; Polymyalgia Rheumatica; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Rheumatic Diseases; Rituximab; Spondylarthropathies; Spondylitis, Ankylosing; Sulfasalazine; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
[TNF targetting therapy for rheumatoid arthritis].
Topics: Adalimumab; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Methotrexate; Product Surveillance, Postmarketing; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2006 |
Remission, a therapeutic goal in inflammatory arthropathies? Clinical data from adalimumab studies.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Radiography; Remission Induction; Treatment Outcome | 2006 |
The use of low dose methotrexate in rheumatoid arthritis - are we entering a new era of therapeutic drug monitoring and pharmacogenomics?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Monitoring; Enzymes; Humans; Methotrexate; Pharmacogenetics; Polyglutamic Acid; Polymorphism, Genetic | 2006 |
Strategies to control disease in rheumatoid arthritis with tumor necrosis factor antagonists-an opportunity to improve outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2006 |
Drug Insight: resistance to methotrexate and other disease-modifying antirheumatic drugs--from bench to bedside.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Humans; Methotrexate; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic | 2007 |
[Pharmacogenomics of antirheumatic drugs and personalized medicine for rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Individuality; Methotrexate; Pharmacogenetics; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
Management of established rheumatoid arthritis with an emphasis on pharmacotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Outcome and Process Assessment, Health Care; Prognosis; Quality of Life | 2007 |
The use of biological agents in the treatment of rheumatoid arthritis.
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunoconjugates; Immunologic Factors; Immunosuppressive Agents; Methotrexate; Remission Induction; Tumor Necrosis Factor-alpha | 2007 |
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Glomerular Filtration Rate; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2007 |
The comparative safety and effectiveness of TNF-alpha antagonists [corrected].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Medicare; Methotrexate; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha; United States; United States Agency for Healthcare Research and Quality | 2007 |
[New therapeutic strategy of rheumatoid arthritis to reach the goal of suppression of joint destruction].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Joints; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2007 |
[Inhibition of radiographic progression in rheumatoid arthritis by anti-rheumatic drugs (DMARDs)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclosporine; Disease Progression; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Radiography; Remission Induction; Sulfasalazine | 2007 |
[B cell depletion therapy using anti-CD20 antibodies in rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Rituximab | 2007 |
Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Calcineurin Inhibitors; Cyclosporine; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Safety; T-Lymphocytes; Tacrolimus; Tacrolimus Binding Proteins | 2007 |
Early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Genetic Markers; Glucocorticoids; Humans; Magnetic Resonance Imaging; Methotrexate; Prognosis; Tumor Necrosis Factor-alpha | 2007 |
[Biological therapy of arthritis and systemic autoimmune diseases].
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; B-Lymphocytes; Biological Therapy; Dermatomyositis; Humans; Lupus Erythematosus, Systemic; Methotrexate; Polymyositis; Scleroderma, Systemic; Sjogren's Syndrome; Spondylitis, Ankylosing; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2007 |
[Rational therapeutic approach in rheumatoid arthritis].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Joint Prosthesis; Leflunomide; Methotrexate; Prostheses and Implants; Sulfasalazine | 2006 |
The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Rheumatoid arthritis and reproduction.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lactation; Methotrexate; Parity; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy, High-Risk; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
Antirheumatic drugs and gene signatures.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Gene Expression; Gene Expression Profiling; Humans; Infliximab; Methotrexate; Oligonucleotide Array Sequence Analysis | 2007 |
Etanercept: a review of its use in the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Protein Binding; Quality of Life; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2007 |
The pharmacogenetics of methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Thymidylate Synthase; Treatment Outcome | 2007 |
[Biologics: current therapeutic strategies for rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2007 |
[Mortality and functional prognosis in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Predictive Value of Tests; Prognosis; Radiography; Survival Rate | 2007 |
[Targeting CD20 in rheumatoid arthritis].
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Drug Therapy, Combination; Humans; Methotrexate; Mice; Randomized Controlled Trials as Topic; Rituximab | 2007 |
[Infliximab].
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pneumonia; Product Surveillance, Postmarketing; Treatment Outcome; Tuberculosis | 2007 |
[Window of opportunity for treatment of rheumatoid arthritis].
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Early Diagnosis; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
[Selection of one of the TNF blockers; infliximab and etanercept].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2007 |
[Effective combination therapy of TNF antagonists with DMARDs].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cysteine; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
[Management for TNF failure].
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Design; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Receptors, Tumor Necrosis Factor; Rituximab; Treatment Failure; Tumor Necrosis Factor-alpha | 2007 |
[Induction of malignant neoplasm].
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Lymphoma; Methotrexate; Neoplasms; Receptors, Tumor Necrosis Factor; Risk; Tumor Necrosis Factor-alpha | 2007 |
[Economic evaluation of a new treatment for rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor | 2007 |
[Pathologic condition of osteoporosis in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Bone Remodeling; Bone Resorption; Cell Differentiation; Cyclosporine; Disease Progression; Glucocorticoids; Humans; Menopause; Methotrexate; Osteoclasts; Osteoporosis; RANK Ligand; Tumor Necrosis Factor-alpha | 2007 |
Combination therapy for rheumatoid arthritis: methotrexate and sulfasalazine together or with other DMARDs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine | 2007 |
A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Genotype; Haplotypes; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Pulmonary manifestations of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lung Diseases; Male; Methotrexate; Pleural Diseases; Sex Factors; Smoking | 2007 |
What is the role of rituximab in the treatment of rheumatoid arthritis?
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Drug Therapy, Combination; Humans; Methotrexate; Rituximab | 2007 |
Established rheumatoid arthritis: clinical assessments.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Outcome and Process Assessment, Health Care; Prognosis; Risk Assessment; Risk Factors | 2007 |
Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate; Pharmacogenetics | 2007 |
Tight control in the treatment of rheumatoid arthritis: efficacy and feasibility.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Remission Induction; Research Design; Treatment Outcome | 2007 |
Meta-analysis of the combination of TNF inhibitors plus MTX compared to MTX monotherapy, and the adjusted indirect comparison of TNF inhibitors in patients suffering from active rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Treatment, management, and monitoring of established rheumatoid arthritis.
Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Humans; Hydrotherapy; Hydroxychloroquine; Immunoconjugates; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Methotrexate; Physical Therapy Modalities; Primary Health Care; Prognosis; Quality of Life; Receptors, Tumor Necrosis Factor; Rituximab; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2007 |
Rituximab for the treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Patient Education as Topic; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.
Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome | 2008 |
[Secondary osteoporosis. Bisphosphonates as a possible strategy for the prevention of bone destruction in rheumatoid arthritis].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density Conservation Agents; Bone Resorption; Diphosphonates; Drug Therapy, Combination; Humans; Imidazoles; Methotrexate; Osteoclasts; Zoledronic Acid | 2007 |
The burden of rheumatoid arthritis and access to treatment: a medical overview.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Austria; Cost of Illness; Health Services Accessibility; Humans; Methotrexate; Severity of Illness Index | 2008 |
Pharmacogenomics in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Biotransformation; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Patient Selection; Pharmacogenetics; Phenotype; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
An update on methotrexate pharmacogenetics in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic | 2008 |
Immunization of patients with rheumatoid arthritis with antitumor necrosis factor alpha therapy and methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Tumor Necrosis Factor-alpha; Viral Vaccines; Virus Diseases | 2008 |
Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Tailor-made therapy in rheumatoid arthritis: fact or fiction?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Prognosis | 2008 |
Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 1983 |
Problems of antiarthritic therapy in the elderly.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Allopurinol; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Chloroquine; Female; Gold; Gout; Humans; Male; Methotrexate; Middle Aged; Osteoarthritis; Penicillamine; Probenecid | 1984 |
Immunosuppressant therapy.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antilymphocyte Serum; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Cyclosporins; Fluorouracil; Humans; Immunosuppressive Agents; Leukocytes; Methotrexate; Vinca Alkaloids | 1984 |
Immunosuppressive therapy in the treatment of autoimmune diseases.
Topics: Adolescent; Adrenal Cortex Hormones; Alkylating Agents; Anemia; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Antilymphocyte Serum; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Colchicine; Cyclosporins; Danazol; Female; Hepatitis, Chronic; Humans; Immunoglobulin G; Immunosuppressive Agents; Levamisole; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Methotrexate; Multiple Sclerosis; Pregnancy | 1984 |
[A case of rheumatoid arthritis with malignant lymphoma taking methotrexate].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Humans; Ileal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate | 1995 |
[Pneumocystis carinii pneumonia associated with low dose methotrexate treatment for malignant rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Methotrexate; Pneumonia, Pneumocystis; Vasculitis | 1995 |
Methotrexate in rheumatoid arthritis. An update.
Topics: Animals; Arthritis, Rheumatoid; Humans; Methotrexate | 1994 |
Choroidal infiltrates as the initial manifestation of lymphoma in rheumatoid arthritis after treatment with low-dose methotrexate.
Topics: Antigens, CD; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; Arthritis, Rheumatoid; Biopsy; Cell Adhesion Molecules; Cell Movement; Choroid Neoplasms; Diagnosis, Differential; Fatal Outcome; Female; Humans; Immunophenotyping; Lectins; Lymphatic Metastasis; Lymphoma, B-Cell; Methotrexate; Middle Aged; Ophthalmoscopy; Sialic Acid Binding Ig-like Lectin 2 | 1994 |
Methotrexate for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic | 1995 |
Sulfasalazine. A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dosage Forms; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility; Humans; Male; Methotrexate; Pregnancy; Pregnancy Complications; Sulfasalazine | 1995 |
Disease-modifying antirheumatic drugs, including methotrexate, gold, antimalarials, and D-penicillamine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cysteine; Drug Therapy, Combination; Gold; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1995 |
Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: a retrospective study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Hodgkin Disease; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasms, Second Primary; Retrospective Studies | 1995 |
[Lymphoma induced by low-dose methotrexate in rheumatoid arthritis with severe lymphopenia].
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Lymphopenia; Methotrexate; Middle Aged | 1995 |
Infections during low-dose methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prospective Studies; Psoriasis | 1995 |
A novel approach to the development of anti-inflammatory agents: adenosine release at inflamed sites.
Topics: Adenosine; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; Sulfasalazine | 1995 |
[Side-effects during treatment of rheumatoid arthritis with methotrexate].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Risk Factors | 1994 |
[Lymphoma during treatment of rheumatoid arthritis with low-dose methotrexate: a new case].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged | 1994 |
[Does methotrexate induce "rheumatoid nodules"? Case report and discussion of the literature].
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule | 1994 |
Recovery from rheumatoid cerebral vasculitis by low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Basilar Artery; Cerebral Infarction; Cerebrovascular Disorders; Female; Humans; Methotrexate; Middle Aged; Vasculitis; Vertebral Artery | 1994 |
Should folate supplementation be routinely recommended for older patients receiving methotrexate?
Topics: Aging; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Geriatric Assessment; Humans; Leucovorin; Methotrexate | 1994 |
Rheumatoid arthritis: new approaches for its evaluation and management.
Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diagnosis, Differential; Exercise Therapy; Health Status Indicators; Humans; Magnetic Resonance Imaging; Methotrexate | 1995 |
Methotrexate for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Methotrexate | 1994 |
Approach to the patient with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Immunotherapy; Male; Methotrexate; Penicillamine; Sulfasalazine | 1994 |
Disease-modifying antirheumatic drugs, including methotrexate, sulfasalazine, gold, antimalarials, and penicillamine.
Topics: Age Factors; Antimalarials; Arthritis, Rheumatoid; Clinical Trials as Topic; Cysteine; Digestive System; Gold; Humans; Liver; Methotrexate; Penicillamine; Sulfasalazine | 1994 |
Should methotrexate be used to treat early rheumatoid arthritis?
Topics: Adenosine; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Leukotriene B4; Lymphocytes; Meta-Analysis as Topic; Methotrexate; Neutrophils | 1994 |
Methotrexate-related pulmonary complications in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Risk Factors | 1994 |
Monitoring patients taking methotrexate for hepatotoxicity. Does the standard of care match published guidelines?
Topics: Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Clinical Protocols; Connecticut; Drug Monitoring; Follow-Up Studies; Gastroenterology; Humans; Liver; Liver Diseases; Massachusetts; Methotrexate; Practice Guidelines as Topic; Psoriasis; Referral and Consultation | 1994 |
Serious problems with methotrexate?
Topics: Arthritis, Rheumatoid; Humans; Kidney Diseases; Liver Cirrhosis; Lung Diseases; Methotrexate | 1994 |
[Methods of the methotrexate utilization in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate; Treatment Outcome | 1994 |
Methotrexate: adverse reactions and major toxicities.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Hematologic Diseases; Humans; Lung Diseases; Methotrexate | 1994 |
Low-dose methotrexate in rheumatic diseases--efficacy, side effects, and risk factors for side effects.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Liver Cirrhosis; Lung Diseases; Methotrexate; Randomized Controlled Trials as Topic; Risk Factors; Vascular Diseases | 1994 |
[Renal damage in rheumatoid arthritis].
Topics: Adult; Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclosporine; Female; Glomerulonephritis; Gold; Humans; Kidney Diseases; Kidney Failure, Chronic; Male; Methotrexate; Middle Aged; Penicillamine; Vasculitis | 1994 |
Optimizing combination chemotherapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate; Penicillamine | 1993 |
The mechanism of action of methotrexate in rheumatoid arthritis: the search continues.
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Humans; Leukotriene Antagonists; Lipoxygenase Inhibitors; Methotrexate; Thymidine | 1994 |
[Fatal outcome of pneumocystis-carinii pneumonia under low-dose methotrexate and prednisone therapy for chronic rheumatoid arthritis. Case report and literature review].
Topics: Aged; Arthritis, Rheumatoid; Candida; Candidiasis; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Maxillary Sinusitis; Methotrexate; Pneumonia, Pneumocystis; Prednisone | 1994 |
Methotrexate in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Humans; Methotrexate | 1993 |
[Weekly low-dose methotrexate in rheumatoid arthritis. Review of the literature].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Interactions; Hematologic Diseases; Humans; Immune System Diseases; Interleukins; Leukocytes, Mononuclear; Lung Diseases; Methotrexate; Neutrophils | 1993 |
Early, aggressive therapy for rheumatoid arthritis: concerns, descriptions, and estimate of outcome.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome | 1993 |
Methotrexate in juvenile rheumatoid arthritis. Do the benefits outweigh the risks?
Topics: Arthritis, Juvenile; Arthritis, Rheumatoid; Humans; Infections; Kidney; Liver; Methotrexate; Reproduction; Risk | 1993 |
Methotrexate in rheumatoid arthritis: can current knowledge and experience justify its use as a first-line disease-modifying agent?
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Adult; Aged; Arthritis, Rheumatoid; Bone Marrow; Digestive System; Female; Humans; Liver; Lung; Male; Methotrexate; Pregnancy | 1993 |
[Malignant lymphoma in rheumatoid arthritis treated by low doses of methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate | 1993 |
Rheumatoid arthritis: new science, new treatment.
Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cyclohexanes; Diphtheria Toxin; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 4, Human; Humans; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Interleukin-2; Lymphocyte Activation; Male; Methotrexate; Minocycline; Neoplasm Proteins; O-(Chloroacetylcarbamoyl)fumagillol; Parvoviridae; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Sesquiterpenes; Sialoglycoproteins; Synovitis; Tumor Necrosis Factor Decoy Receptors | 1993 |
[Characteristics of low-dose methotrexate therapy in rheumatoid diseases].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Long-Term Care; Metabolic Clearance Rate; Methotrexate | 1993 |
New focus on treatment for rheumatoid arthritis.
Topics: Animals; Anti-Bacterial Agents; Arthritis, Rheumatoid; Dogs; Humans; Hydroxychloroquine; Methotrexate; Rats | 1993 |
Drug treatment of arthritis. Update on conventional and less conventional methods.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aurothioglucose; Azathioprine; Glucosamine; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Methotrexate; Osteoarthritis; Ribose | 1993 |
[A case report--pulmonary cryptococcosis associated with systemic lupus erythematosus and review of 44 cases in Japan].
Topics: Arthritis, Rheumatoid; Cryptococcosis; Drug Therapy, Combination; Female; Fluconazole; Flucytosine; Humans; Japan; Lung Diseases, Fungal; Lupus Erythematosus, Systemic; Methotrexate; Middle Aged; Opportunistic Infections | 1993 |
[Development of multiple subcutaneous nodules in a patient with rheumatoid arthritis during methotrexate therapy].
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Skin | 1993 |
Selected surgical topics in rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis, Rheumatoid; Contraindications; Dose-Response Relationship, Drug; Humans; Intubation, Intratracheal; Joint Prosthesis; Methotrexate; Premedication | 1993 |
Fatal pulmonary fibrosis complicating low dose methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Methotrexate; Pulmonary Fibrosis; Radiography | 1995 |
[Methotrexate in rheumatology: a therapeutic revolution].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 1995 |
Combining sulphasalazine and methotrexate in rheumatoid arthritis: early clinical impressions.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine | 1995 |
Practical clinical pharmacology and drug interactions of low-dose methotrexate therapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate | 1995 |
Possible mechanisms of action of methotrexate in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 1995 |
Efficacy of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate; Radiography | 1995 |
Adverse events in methotrexate-treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pregnancy; Pregnancy Outcome | 1995 |
[Emergency therapy of collagen diseases and their complications].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Collagen Diseases; Drug Administration Schedule; Emergencies; Humans; Hypertension; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Methotrexate; Methylprednisolone; Prednisolone | 1995 |
[Cutaneous pseudolymphoma during treatment of rheumatoid polyarthritis with low-dose methotrexate].
Topics: Arthritis, Rheumatoid; Diagnosis, Differential; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Lymphoma; Male; Methotrexate; Middle Aged; Skin Neoplasms | 1995 |
Disease-modifying antirheumatic drugs. Potential effects in older patients.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sulfasalazine | 1995 |
Folate supplementation and methotrexate.
Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate | 1995 |
The changing face of therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy; Humans; Methotrexate | 1995 |
Methotrexate in rheumatoid arthritis: toxicity issues.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus, Type 1; Humans; Liver; Lung; Methotrexate | 1996 |
Acute febrile toxic reaction in patients with refractory rheumatoid arthritis who are receiving combined therapy with methotrexate and azathioprine.
Topics: Acute Disease; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cohort Studies; Drug Therapy, Combination; Female; Fever; Humans; Leukocytosis; Male; Methotrexate; Retrospective Studies; Time Factors; Vasculitis, Leukocytoclastic, Cutaneous | 1996 |
Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged | 1996 |
[Methotrexate treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 1996 |
Clinical use of cyclosporin in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Cyclosporine; Drug Costs; Drug Therapy, Combination; Humans; Methotrexate | 1995 |
Combination therapy with cyclosporin in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate | 1995 |
[Pancytopenia and Pneumocystis carinii pneumonia associated with low dose methotrexate pulse therapy for rheumatoid arthritis--case report and review of literature].
Topics: Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Pancytopenia; Pneumonia, Pneumocystis; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 1996 |
Methotrexate and other chemotherapeutic agents used to treat psoriasis.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dermatologic Agents; Drug Combinations; Drug Monitoring; Humans; Immunosuppressive Agents; Methotrexate; Photochemotherapy; Psoriasis | 1995 |
The role of anti-malarials in rheumatoid arthritis--the American experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Humans; Hydroxychloroquine; Liver; Methotrexate; United States | 1996 |
The use of antimalarials in combination with other disease modifying agents in RA--the British experience.
Topics: Antimalarials; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Gold; Humans; Methotrexate; Penicillamine; Retina; Sulfasalazine; United Kingdom | 1996 |
Combination therapy with cyclosporin in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Forecasting; Humans; Methotrexate; Rheumatology | 1996 |
Pneumocystis carinii pneumonia in rheumatoid arthritis patients treated with methotrexate. A report of two cases.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Methotrexate; Middle Aged; Pneumonia, Pneumocystis; Prednisone; Trimethoprim, Sulfamethoxazole Drug Combination | 1996 |
Combination sulfasalazine and methotrexate in the management of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine | 1996 |
Initial experience combining methotrexate with biologic agents for treating rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; CD4 Antigens; Humans; Immunotherapy; Methotrexate | 1996 |
Medical aspects of rheumatoid arthritis. Diagnosis and treatment.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Carpal Tunnel Syndrome; Diagnosis, Differential; Female; Hand; Humans; Methotrexate; Middle Aged; Polymyalgia Rheumatica; Synovial Fluid; Wrist | 1996 |
Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Half-Life; Humans; Methotrexate | 1996 |
Molecular therapeutics. Methotrexate and its mechanism of action.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 1996 |
[Drug-induced renal disorders in patients with rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Cysteine; Humans; Kidney Diseases; Methotrexate; ortho-Aminobenzoates | 1996 |
Review article: methotrexate in gastroenterology--dangerous villain or simply misunderstood?
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Gastroenterology; Gastrointestinal Agents; Humans; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Methotrexate; Psoriasis | 1996 |
Methotrexate update.
Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Dermatologic Agents; Drug Therapy, Combination; Folic Acid; Hematinics; Humans; Kidney; Leucovorin; Liver; Lung; Methotrexate; Psoriasis | 1996 |
Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis: comment on the article by Gutierrez-Ureña et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Folic Acid; Humans; Methotrexate; Pancytopenia | 1997 |
[Non-cancer uses of methotrexate].
Topics: Adult; Aged; Anti-Asthmatic Agents; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Asthma; Child; Contraindications; Dermatologic Agents; Drug Tolerance; Humans; Methotrexate; Psoriasis | 1996 |
[Low dose methotrexate therapy in chronic polyarthritis--an update].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Long-Term Care; Metabolic Clearance Rate; Methotrexate; Treatment Outcome | 1996 |
Liver toxicity does not have to follow methotrexate therapy of patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Liver; Methotrexate; Time Factors | 1997 |
Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; France; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies | 1997 |
[ACR preliminary definition, of improvement in rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate; Quality of Life; Randomized Controlled Trials as Topic; Societies, Medical; Treatment Outcome; United States | 1996 |
Methotrexate related cutaneous vasculitis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Fingers; Humans; Methotrexate; Skin Diseases, Vascular; Vasculitis, Leukocytoclastic, Cutaneous | 1997 |
Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.
Topics: Aged; Alveolitis, Extrinsic Allergic; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Prognosis; Respiratory Function Tests; Risk Factors | 1997 |
Disease-modifying antirheumatic drugs.
Topics: Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Gold; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1997 |
Lymphoma in patients with rheumatoid arthritis: association with the disease state or methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Risk Factors | 1997 |
Rheumatologic view of the rheumatoid foot.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Foot Diseases; Forefoot, Human; Humans; Methotrexate; Patient Education as Topic; Synovitis | 1997 |
[General principles of immunosuppressive therapy of diseases of rheumatic origin].
Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Humans; Immunosuppressive Agents; Methotrexate; Rheumatic Diseases | 1997 |
Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Lung; Lung Diseases; Male; Methotrexate; Middle Aged; Radiography | 1997 |
The mechanism of action of methotrexate.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Methylation | 1997 |
Methotrexate use in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 1997 |
Methotrexate use in miscellaneous inflammatory diseases.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Connective Tissue Diseases; Humans; Inflammation; Lupus Erythematosus, Systemic; Methotrexate; Myositis; Sarcoidosis; Scleroderma, Systemic; Still's Disease, Adult-Onset | 1997 |
Methotrexate pulmonary toxicity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Radiography, Thoracic | 1997 |
The use of folates concomitantly with low-dose pulse methotrexate.
Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate | 1997 |
Perioperative use of methotrexate in patients with rheumatoid arthritis undergoing orthopedic surgery.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Orthopedic Procedures; Perioperative Care; Treatment Outcome | 1997 |
[Combined administration of long-acting antirheumatic drugs in the treatment of chronic polyarthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Cyclosporins; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Humans; Hydroxychloroquine; Immunosuppressive Agents; Methotrexate; Organogold Compounds; Penicillamine; Prospective Studies; Randomized Controlled Trials as Topic; Sulfasalazine | 1997 |
The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Rheumatic Diseases; Treatment Outcome | 1997 |
The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials.
Topics: Adult; Antidotes; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic | 1998 |
Osteoporosis in rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Animals; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Folic Acid Antagonists; Humans; Menopause; Methotrexate; Middle Aged; Movement; Osteoporosis; Rats; Sex Factors | 1997 |
[Drug delivery system of anti-inflammatory and anti-rheumatic drugs].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Drug Delivery Systems; Humans; Methotrexate; Prodrugs; Steroids | 1998 |
[Basic therapeutic combination therapy in chronic polyarthritis: an overview].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome | 1998 |
Combination of sulphasalazine and methotrexate in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Quality of Life; Sulfasalazine; Treatment Outcome | 1998 |
Combination therapy for rheumatoid arthritis with methotrexate and cyclosporine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome | 1998 |
Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 1998 |
Lymphoproliferative disorders in rheumatoid arthritis patients on low-dose methotrexate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immunocompromised Host; Lymphoma; Methotrexate; Middle Aged; Tumor Virus Infections | 1998 |
Disease-modifying antirheumatic drugs.
Topics: Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Liver; Lung; Methotrexate; Organogold Compounds; Penicillamine; Sulfasalazine | 1998 |
Methotrexate hepatotoxicity: what is the evidence?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dermatologic Agents; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Methotrexate; Psoriasis; Risk Assessment | 1998 |
Triple therapy with methotrexate, sulfasalazine, and hydroxychloroquine in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine; Treatment Outcome | 1998 |
Soluble tumor necrosis factor receptor (p75) fusion protein (ENBREL) as a therapy for rheumatoid arthritis.
Topics: Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Recombinant Proteins; Treatment Outcome | 1998 |
Methotrexate and emerging therapies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Methotrexate; Neoplasms; Opportunistic Infections | 1998 |
Combination therapy with biologic agents in rheumatoid arthritis: perils and promise.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha | 1998 |
[Combination therapy of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Chloroquine; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Methotrexate; Penicillamine; Randomized Controlled Trials as Topic; Sulfasalazine | 1998 |
Aggressive treatment of early rheumatoid arthritis to prevent joint damage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Management; Disease Progression; Humans; Methotrexate; Prednisone; Time Factors | 1998 |
[Methotrexate and folates in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Randomized Controlled Trials as Topic | 1999 |
Should methotrexate be a first-line treatment for rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Patient Selection; Time Factors | 1999 |
[62nd Congress of the American College of Rheumatology, San Diego, 8-12 November 1998].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Child, Preschool; Etanercept; Female; Humans; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Recombinant Proteins; Rheumatology; Societies, Medical; Sulfasalazine; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Disease-modifying antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Methotrexate; Sulfasalazine | 1999 |
Molecular and cellular effects of methotrexate.
Topics: Adenosine; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Methotrexate; Methylation | 1999 |
[Advances in the drug therapy of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate | 1997 |
Lymphoma in patients with rheumatoid arthritis: what is the evidence of a link with methotrexate?
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Epstein-Barr Virus Infections; Female; Humans; Immunosuppression Therapy; Lymphoma; Male; Methotrexate; Middle Aged; Remission, Spontaneous; Risk Factors | 1999 |
Methotrexate and leflunomide: biochemical basis for combination therapy in the treatment of rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Cell Division; Cytokines; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Methotrexate; Molecular Structure; Purines; Pyrimidines; Treatment Outcome | 1999 |
Two cases of methotrexate induced lymphomas in rheumatoid arthritis: an association with increased serum IgE.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin E; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged | 1999 |
New treatments for rheumatoid arthritis. Available and upcoming slow-acting antirheumatic drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha | 1999 |
[Trends in the treatment of rheumatic diseases].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Bone Marrow Transplantation; Cyclooxygenase Inhibitors; Cyclosporine; Hand; Humans; Immunoglobulins, Intravenous; Knee Joint; Methotrexate; Osteoarthritis; Plasmapheresis; Radiography; Rheumatic Diseases; Tumor Necrosis Factor-alpha | 1999 |
[Methotrexate in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female; Humans; Male; Methotrexate; Patient Selection; Pneumonia; Risk Assessment; Treatment Outcome | 1996 |
[Rheumatoid polyarthritis: etiology, diagnosis, course, treatment principles].
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cytokines; Diagnosis, Differential; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Organogold Compounds; Prognosis; Radiography; Sulfasalazine | 1999 |
Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Placebos; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome | 2000 |
The role of current strategies in the future treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Forecasting; Humans; Methotrexate | 1999 |
Rheumatoid arthritis: new developments in the use of existing therapies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Prednisolone; Sulfasalazine | 1999 |
[Pharmacotherapy of patients with (early) rheumatoid arthritis].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Transplantation; Drug Administration Schedule; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prednisone | 2000 |
Radiographic assessment of disease progression in rheumatoid arthritis patients treated with methotrexate or minocycline.
Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Methotrexate; Minocycline; Radiography; Treatment Outcome | 2000 |
Reversible methotrexate associated lymphoproliferative disease evolving into Hodgkin's disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Virus Activation | 2000 |
[Role of anti-TNF therapy in rheumatoid arthritis].
Topics: Adult; Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Immunohistochemistry; Immunosuppressive Agents; Infliximab; Methotrexate; Mice; Mice, Inbred DBA; Mice, Transgenic; Placebos; Randomized Controlled Trials as Topic; Rats; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfasalazine; Synovial Fluid; Tumor Necrosis Factor-alpha | 2000 |
New medications for use in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Fees, Pharmaceutical; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor | 2000 |
Rheumatoid arthritis and osteoporosis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fractures, Spontaneous; Humans; Male; Methotrexate; Osteoporosis; Risk Factors | 2000 |
Anti-cytokine therapy for rheumatoid arthritis.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cytokines; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin-1; Methotrexate; Receptors, Tumor Necrosis Factor; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Gastrointestinal Diseases; Hematologic Diseases; Humans; Leucovorin; Methotrexate | 2000 |
Methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid Antagonists; Humans; Methotrexate | 2000 |
Mechanisms of action of methotrexate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate; Purine Nucleotides | 2000 |
Methotrexate use in rheumatoid arthritis. A Clinician's perspective.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Methotrexate | 2000 |
Infliximab: a review of its use in the management of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Methotrexate; Tumor Necrosis Factor-alpha | 2000 |
[Cytostatic drugs in the treatment of rheumatic and connective tissue diseases].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Humans; Methotrexate; Podophyllotoxin | 1998 |
DMARDs in the treatment of rheumatoid arthritis: current agents and future developments.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Cyclosporins; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Isoxazoles; Methotrexate; Penicillamine; Treatment Outcome | 2000 |
Low dose weekly methotrexate in early pregnancy. A case series and review of the literature.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Gestational Age; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy Outcome | 2000 |
Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Organogold Compounds; Sulfasalazine; Treatment Refusal | 2000 |
The treatment of rheumatoid arthritis: a review of recent clinical trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Prognosis; Prospective Studies; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 1999 |
[New therapeutic approaches. 2. New anti-rheumatic drugs: with special reference to methotrexate].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2000 |
[New therapeutic approaches. 3. Current status and overview of biological products].
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate | 2000 |
[Listeria arthritis in chronic polyarthritis during low dose prednisolone and methotrexate therapy. Case report and review of the literature].
Topics: Aged; Arthritis, Infectious; Arthritis, Rheumatoid; Arthroscopy; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Listeria monocytogenes; Listeriosis; Methotrexate; Prednisolone; Synovitis | 2001 |
Cytomegalovirus pneumonia in a rheumatoid arthritis patient on low dose methotrexate.
Topics: Adult; Antiviral Agents; Arthritis, Rheumatoid; Cytomegalovirus Infections; Follow-Up Studies; Humans; Immunocompromised Host; Male; Methotrexate; Pneumonia, Viral; Risk Assessment; Treatment Outcome | 1998 |
Rational use of new and existing disease-modifying agents in rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Costs; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Sulfasalazine | 2001 |
Leflunomide and methotrexate.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Treatment Outcome | 2001 |
Anti-interleukin-1 therapy in rheumatic diseases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Models, Animal; Drug Therapy, Combination; Genetic Therapy; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methotrexate; Sialoglycoproteins; Treatment Outcome | 2001 |
Anti-tumor necrosis factor therapies.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Treatment Outcome; Tumor Necrosis Factor-alpha | 2001 |
How is it best to treat early rheumatoid arthritis patients?
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Prognosis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2001 |
Disease modifying antirheumatic drugs: longterm safety issues.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Safety; Sulfasalazine; Treatment Outcome | 2001 |
Tumour necrosis factor-alpha blockers in rheumatoid arthritis: review of the clinical experience.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2001 |
Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis.
Topics: Adenosine; Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cell Cycle; Cyclic AMP; Cyclooxygenase Inhibitors; Cytokines; fas Receptor; Humans; Metalloendopeptidases; Methotrexate; Rats | 2001 |
Combination therapy in rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor | 2001 |
Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Practice Guidelines as Topic | 2001 |
Current concepts regarding pharmacologic treatment of rheumatoid and osteoarthritis.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhibitors; Digestive System; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Lactones; Leflunomide; Methotrexate; Osteoarthritis; Pyrazoles; Receptors, Tumor Necrosis Factor; Sulfasalazine; Sulfonamides; Sulfones | 2001 |
Cutaneous lymphoma associated with Epstein-Barr virus infection in 2 patients treated with methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Burkitt Lymphoma; Dermatologic Agents; Dermatomyositis; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; In Situ Hybridization; Lymphoma, T-Cell, Cutaneous; Male; Methotrexate; Middle Aged; RNA, Viral; Skin | 2001 |
[Local injection therapy of rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Adult; Animals; Antirheumatic Agents; Antiviral Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Enzyme Inhibitors; Ganciclovir; Genetic Therapy; Haplorhini; Hormones; Humans; Injections, Intra-Articular; Methotrexate; Mice; Osmium Tetroxide; Osteoarthritis; Photochemotherapy; Rats; Rifampin; Somatostatin; Synovectomy; Synovitis; Time Factors | 2001 |
[Extracorporeal therapy of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Component Removal; Combined Modality Therapy; Controlled Clinical Trials as Topic; Cyclophosphamide; Cytapheresis; Double-Blind Method; Glucocorticoids; Hemofiltration; Humans; Immunosorbent Techniques; Immunosuppressive Agents; Leukapheresis; Methotrexate; Methylprednisolone; Plasmapheresis; Time Factors | 2001 |
[Methotrexate-induced lung pathology in patients with rheumatoid arthritis].
Topics: Acute Disease; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate | 2001 |
[Treatment of rheumatoid arthritis by inhibition of tumor necrosis factor with infliximab or etanercept].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2001 |
Pharmaceutical agents for the treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Drug Utilization; Humans; Methotrexate; Quality of Life; Tumor Necrosis Factor-alpha; United States | 2001 |
Progress in the treatment of rheumatoid arthritis.
Topics: Analgesics; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Etanercept; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Minocycline; Penicillamine; Receptors, Tumor Necrosis Factor; Sulfasalazine | 2001 |
[New therapy developments in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2001 |
Rheumatoid arthritis, methotrexate, and lymphoma: risk substitution, or cat and mouse with Epstein-Barr virus?
Topics: Arthritis, Rheumatoid; Burkitt Lymphoma; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Risk | 2001 |
[Safety aspects of folic acid for the general population].
Topics: Adult; Animals; Anticonvulsants; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Child; Cohort Studies; Double-Blind Method; Drug Hypersensitivity; Drug Interactions; Epilepsy; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant, Newborn; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Placebos; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Vitamin B 12 Deficiency; Zinc | 2002 |
Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis and other rheumatic diseases (April 2001).
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Controlled Clinical Trials as Topic; Female; Humans; Male; Meta-Analysis as Topic; Methotrexate; Pregnancy; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Rheumatic Diseases; Tumor Necrosis Factor-alpha | 2001 |
"Stepping-up" from methotrexate: a systematic review of randomised placebo controlled trials in patients with rheumatoid arthritis with an incomplete response to methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Maximum Tolerated Dose; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2001 |
Rheumatoid arthritis and tumor necrosis factor alpha.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Humans; Infliximab; Interleukin-1; Interleukin-15; Interleukin-17; Interleukin-18; Methotrexate; Tumor Necrosis Factor-alpha | 2001 |
Rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Incidence; Male; Methotrexate; Prednisone | 2002 |
[Pharmacogenomics of the immunosuppressive agents].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors | 2002 |
[Bone destruction and bone loss in rheumatoid arthritis--mechanism, prevention and treatment].
Topics: Arthritis, Rheumatoid; Bone Density; Bone Resorption; Calcium, Dietary; Cholecalciferol; Cytokines; Glycoproteins; Humans; Methotrexate; Osteoclasts; Osteoporosis; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Synovial Membrane | 2002 |
[Combination therapy for rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Treatment Outcome | 2002 |
Advances in the medical management of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Steroids; Sulfasalazine; Treatment Outcome | 2002 |
Molecular action of methotrexate in inflammatory diseases.
Topics: Adenosine; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Methotrexate; Receptors, Purinergic P1 | 2002 |
Treatment of rheumatoid arthritis with cytostatic drugs.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Gold; Humans; Immunosuppression Therapy; Methotrexate; Time Factors | 1975 |
Does folate supplementation make sense in patients with rheumatoid arthritis treated with methotrexate?
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 1992 |
[Current concept of the management of rheumatoid arthritis based on the pathogenesis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Genetic Therapy; Humans; Methotrexate; Prednisolone; Retroviridae Infections; Synovial Membrane | 1992 |
Radiographic evidence of disease progression in methotrexate treated and nonmethotrexate disease modifying antirheumatic drug treated rheumatoid arthritis patients: a meta-analysis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index | 1992 |
Pharmacology of antiarthritic drugs.
Topics: Adrenal Cortex Hormones; Antimalarials; Arthritis, Rheumatoid; Aurothioglucose; Azathioprine; Cyclophosphamide; Gold Sodium Thiomalate; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1992 |
Current concepts in the management of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Antibiotics, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Combinations; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Penicillamine; Research Design; Sulfasalazine | 1992 |
Use of short-term efficacy/toxicity tradeoffs to select second-line drugs in rheumatoid arthritis. A metaanalysis of published clinical trials.
Topics: Antimalarials; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate; Sulfasalazine | 1992 |
Acute pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis: report of five cases and review of published reports.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Female; Forced Expiratory Volume; Humans; Lung; Male; Methotrexate; Middle Aged; Pulmonary Fibrosis; Radiography; Vital Capacity | 1992 |
Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Phenotype | 1992 |
New approaches to the management of rheumatoid arthritis.
Topics: Acquired Immunodeficiency Syndrome; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD4 Antigens; Cyclosporine; Drug Therapy, Combination; Humans; Immunotherapy; Magnetic Resonance Imaging; Methotrexate; Photochemotherapy; Rheumatic Diseases; Rheumatology | 1992 |
Cyclosporine in rheumatoid arthritis: beyond experimentation.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Forecasting; Humans; Methotrexate; Synovial Membrane | 1992 |
Current issues of methotrexate and cyclosporine.
Topics: Arthritis, Rheumatoid; Cyclosporine; Humans; Methotrexate | 1992 |
[The risk profile of low-dose methotrexate in the therapy of chronic polyarthritis].
Topics: Arthritis, Rheumatoid; Chronic Disease; Drug Interactions; Humans; Methotrexate; Risk Factors | 1992 |
Mechanisms of action of methotrexate.
Topics: Arthritis, Rheumatoid; Endothelium; Fibroblasts; Folic Acid; Humans; Immunosuppression Therapy; Inflammation; Methotrexate | 1991 |
Therapy for rheumatoid arthritis: combinations of disease-modifying drugs and new paradigms of treatment.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Penicillamine | 1991 |
[Methotrexate therapy in rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate | 1991 |
[Lung diseases and treatment with methotrexate in rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Female; Humans; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia; Pneumonia, Pneumocystis | 1991 |
Combined DMARDS in rheumatoid arthritis: past, present and future.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Cyclosporins; Drug Therapy, Combination; Humans; Methotrexate | 1991 |
Methotrexate and histologic hepatic abnormalities: a meta-analysis.
Topics: Alcohol Drinking; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Biopsy; Female; Humans; Liver; Liver Cirrhosis; Male; Meta-Analysis as Topic; Methotrexate | 1991 |
[Methotrexate in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Biopsy; Drug Interactions; Humans; Methotrexate | 1991 |
Methotrexate: mechanism of action, pharmacokinetics, clinical indications, and toxicity.
Topics: Arthritis, Rheumatoid; Humans; Liver; Methotrexate; Rheumatic Diseases | 1991 |
Treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dietary Fats, Unsaturated; Humans; Immunotherapy; Methotrexate | 1991 |
[Treatment of rheumatoid polyarthritis with methotrexate].
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 1991 |
Modern management of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate | 1991 |
Pneumocystis carinii pneumonia associated with methotrexate therapy in rheumatoid arthritis.
Topics: Adolescent; Aged; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunosuppression Therapy; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis | 1991 |
Low dose methotrexate therapy for rheumatoid arthritis complicated by pancytopenia and Pneumocystis carinii pneumonia.
Topics: Adolescent; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Opportunistic Infections; Pancytopenia; Pneumonia, Pneumocystis | 1991 |
[New approaches to the therapy of diffuse inflammatory diseases of the connective tissue].
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Connective Tissue Diseases; Cyclosporine; Drug Therapy, Combination; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymph; Methotrexate; Plasmapheresis; Synovitis | 1991 |
The use of combinations of disease-modifying antirheumatic agents in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclophosphamide; Drug Combinations; Gold; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1990 |
Care of the person with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Organogold Compounds; Patient Care Planning; Patient Education as Topic; Penicillamine; Sulfasalazine | 1990 |
The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses.
Topics: Antimalarials; Arthritis, Rheumatoid; Auranofin; Gold; Humans; Meta-Analysis as Topic; Methotrexate; Penicillamine; Sulfasalazine | 1990 |
[Pleuropulmonary manifestations of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Humans; Lung Diseases; Methotrexate; Organogold Compounds; Penicillamine; Pleural Diseases; Respiratory Tract Diseases; Tiopronin | 1990 |
Challenging the pyramid. A new look at therapeutic approaches for rheumatoid arthritis. Earlier intervention with second line therapies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Gold Sodium Thiomalate; Humans; Methotrexate | 1990 |
Combination therapy in rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Humans; Methotrexate; Penicillamine; Sulfasalazine; Time Factors | 1990 |
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis.
Topics: Adolescent; Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis | 1991 |
The risks of antimalarial retinopathy, azathioprine lymphoma and methotrexate hepatotoxicity during the treatment of rheumatoid arthritis.
Topics: Antimalarials; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Lymphoma; Methotrexate; Retinal Diseases; Risk Factors | 1990 |
Long-term methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Blood Cell Count; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Time Factors | 1991 |
Methotrexate--the rapidly acting drug.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Immunosuppressive Agents; Methotrexate; Time Factors | 1990 |
Severe rheumatoid arthritis: current options in drug therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Aspirin; Clinical Protocols; Cyclosporins; Drug Therapy, Combination; Fatty Acids, Omega-3; Glucosamine; Humans; Hydroxychloroquine; Interferon-gamma; Methotrexate; Ribose | 1990 |
Outcome of first-trimester exposure to low-dose methotrexate in eight patients with rheumatic disease.
Topics: Abortifacient Agents; Abortion, Induced; Abortion, Spontaneous; Adult; Arthritis, Rheumatoid; Child; Child Development; Drug Therapy, Combination; Female; Fetus; Follow-Up Studies; Humans; Methotrexate; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk Factors; Teratogens | 1990 |
Longterm experience with low dose weekly methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Life Tables; Methotrexate; Time Factors | 1990 |
Proposition: methotrexate should not be the first second-line agent to be used in rheumatoid arthritis if NSAIDs fail.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Central Nervous System; Humans; Liver; Lung; Methotrexate; Mycoses; Rheumatoid Nodule; Steroids | 1990 |
Resolve: methotrexate is the drug of choice after NSAIDs in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Methotrexate; Monitoring, Physiologic; Radiography | 1990 |
Azathioprine and methotrexate as combination chemotherapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Multicenter Studies as Topic; Structure-Activity Relationship | 1990 |
Methotrexate: mechanism of action in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Cell Division; Collagen; Cytokines; Endopeptidases; Folic Acid; Humans; Immunity, Cellular; Methotrexate; Monocytes | 1990 |
Rheumatoid arthritis. Practical use of medications.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate | 1990 |
Experimental basis of innovative therapies of rheumatoid arthritis.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoimmune Diseases; Chronic Disease; Cyclosporins; Fatty Acids; Humans; Interferons; Methotrexate; Mice; Sulfasalazine; Thymus Hormones | 1989 |
[The combination of cyclosporin A and fluocortolone in the treatment of autoimmune diseases].
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Drug Evaluation; Drug Therapy, Combination; Female; Fluocortolone; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Peptic Ulcer | 1989 |
Rheumatoid arthritis therapy: the slow-acting agents.
Topics: Age Factors; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; Azathioprine; Cyclophosphamide; Gold; Gold Sodium Thiomalate; Humans; Methotrexate; Penicillamine; Prognosis; Steroids; Sulfasalazine; Time Factors | 1989 |
[Methotrexate in the management of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1989 |
Methotrexate in rheumatoid arthritis. Feedback on American College of Physicians guidelines.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Methotrexate; Societies, Medical; United States | 1989 |
[Efficacy and tolerance of methotrexate in rheumatoid polyarthritis. Results of an open study on 104 patients].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Tolerance; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1989 |
[3 cases of pneumopathy during treatment of rheumatoid polyarthritis with methotrexate].
Topics: Arthritis, Rheumatoid; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged | 1989 |
[Acute pneumopathy during the treatment of severe rheumatoid polyarthritis with low fractionated doses of methotrexate administered orally].
Topics: Acute Disease; Administration, Oral; Arthritis, Rheumatoid; Female; Humans; Lung Diseases; Methotrexate; Middle Aged; Radiography | 1989 |
[Methotrexate in rheumatic practice].
Topics: Arthritis; Arthritis, Rheumatoid; Humans; Liver; Lung; Methotrexate; Psoriasis | 1989 |
Methotrexate therapy in the treatment of rheumatoid arthritis.
Topics: Absorption; Animals; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunity; Methotrexate | 1989 |
Immunologic and clinical effects of cytotoxic drugs used in the treatment of rheumatoid arthritis and systemic lupus erythematosus.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; B-Lymphocytes; Cyclophosphamide; Humans; Killer Cells, Natural; Lupus Erythematosus, Systemic; Lymphocytes; Methotrexate; T-Lymphocytes | 1989 |
Methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1989 |
Methotrexate-induced liver abnormalities in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Humans; Liver; Liver Cirrhosis; Methotrexate | 1989 |
Methotrexate in rheumatoid arthritis and related diseases.
Topics: Arthritis, Rheumatoid; Connective Tissue Diseases; Humans; Methotrexate | 1989 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Depression, Chemical; Dermatomyositis; Drug Evaluation; Female; Fertility; Gastrointestinal Diseases; Granulomatosis with Polyangiitis; Humans; Leukopenia; Lupus Erythematosus, Systemic; Male; Methotrexate; Myositis; Neoplasms; Polyarteritis Nodosa; Psoriasis; Pulmonary Fibrosis; Rheumatic Diseases | 1986 |
Investigational therapy in rheumatoid arthritis: a critical review.
Topics: Arthritis, Rheumatoid; Blood Component Removal; Cyclophosphamide; Cyclosporins; Drainage; Humans; Levamisole; Lymphatic Irradiation; Methotrexate; Methylprednisolone; Sulfasalazine; Thoracic Duct | 1988 |
The immunopathogenesis of rheumatoid arthritis.
Topics: Antigens; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; B-Lymphocytes; Herpesvirus 4, Human; Histocompatibility Antigens Class II; HLA-DR4 Antigen; Humans; Lymphokines; Methotrexate; Plasmapheresis; Synovial Membrane; T-Lymphocytes; Virus Diseases | 1985 |
Methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Liver Cirrhosis; Methotrexate; Psoriasis | 1988 |
Life threatening acute pneumonitis during low dose methotrexate treatment for rheumatoid arthritis: a case report and review of the literature.
Topics: Alveolitis, Extrinsic Allergic; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged | 1988 |
New approaches to the treatment of rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Cyclosporins; Drug Therapy, Combination; Humans; Methotrexate; Steroids | 1988 |
[Methotrexate in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1988 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
Rheumatologic causes of pain: rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Gold; Hip Prosthesis; Humans; Methotrexate; Pain; Steroids | 1988 |
Severe reversible interstitial pneumonitis induced by low dose methotrexate: report of a case and review of the literature.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pulmonary Fibrosis | 1988 |
Methotrexate and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1988 |
Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy, and safety.
Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Injections, Intramuscular; Methotrexate | 1987 |
Current concepts in clinical therapeutics: disease-modifying drugs for rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Azathioprine; Bone Marrow; Cyclophosphamide; Digestive System; Female; Gold; HLA Antigens; Humans; Joints; Male; Methotrexate; Penicillamine; Prognosis; Synovitis | 1987 |
[Treatment with methotrexate in patients with rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Humans; Methotrexate | 1987 |
Methotrexate pneumonitis in rheumatoid arthritis: potential risk factors. Four case reports and a review of the literature.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Pneumonia; Radiography; Risk Factors | 1987 |
Management of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyclophosphamide; Drug Therapy, Combination; Felty Syndrome; Gold; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leukapheresis; Lung Diseases; Lymphoid Tissue; Methotrexate; Penicillamine; Plasmapheresis; Radiotherapy; Rheumatic Diseases; Salicylates; Sjogren's Syndrome; Spinal Diseases; Vasculitis | 1986 |
Therapeutic approaches to the treatment of rheumatoid disease.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Azathioprine; Blood Component Removal; Cyclophosphamide; Exercise Therapy; Gold; Humans; Injections; Methotrexate; Patient Education as Topic; Penicillamine; Rest; Salicylates; Self-Help Devices | 1986 |
[Efficacy of methotrexate in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1987 |
The use of methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cell Division; Humans; Injections, Intra-Articular; Methotrexate | 1985 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyositis; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Methotrexate; Neoplasms; Psoriasis; Vasculitis | 1985 |
Clinical pharmacology of very low dose methotrexate for use in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bile; Biological Availability; Brain; Breast Neoplasms; Cell Line; Half-Life; Humans; Intestinal Absorption; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Methotrexate; Neoplasms; Psoriasis; Tritium | 1985 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Gold; Humans; Immunosuppression Therapy; Methotrexate; Pancytopenia; Penicillamine; Placebos; Psoriasis | 1985 |
Longterm methotrexate therapy in rheumatoid arthritis: a review.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans; Hydroxychloroquine; Liver Diseases; Liver Function Tests; Methotrexate; Penicillamine; Prednisone; Psoriasis; Risk | 1985 |
Drug interactions with methotrexate.
Topics: Absorption; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Biological Transport; Cell Membrane; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Humans; Kidney Tubules; Methotrexate; Probenecid; Protein Binding; Salicylates; Serum Albumin; Sulfamethoxazole; Sulfonamides; Tissue Distribution | 1985 |
Toxicity of low dose methotrexate in rheumatoid arthritis.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases | 1985 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Granulomatosis with Polyangiitis; Hepatitis; Humans; Immune Complex Diseases; Immunosuppressive Agents; Infections; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Nephrotic Syndrome; Ophthalmia, Sympathetic; Psoriasis; Thioguanine; Uveitis | 1972 |
[Long-term therapy of immunologic diseases with special reference to the use of immunosuppressive agents].
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Colitis, Ulcerative; Cyclophosphamide; Humans; Immunosuppressive Agents; Liver Cirrhosis; Lupus Erythematosus, Systemic; Methotrexate; Nephritis; Thrombocytopenia; Time Factors | 1969 |
Immunosuppressive drugs in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Nitrogen Mustard Compounds; Penicillamine | 1971 |
Immunosuppressive therapy. 1.
Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Blood Coagulation Disorders; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Dermatomyositis; Factor VIII; Hepatitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Prednisolone; Purpura, Thrombocytopenic; Scleroderma, Systemic | 1972 |
Drug therapy: immunosuppressive agents (second of two parts).
Topics: Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Child; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Methotrexate; Psoriasis; Purines; Sulfhydryl Compounds | 1973 |
An approach to the use of immunosuppressive drugs in nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; Granulomatosis with Polyangiitis; Hepatitis; Humans; Immunosuppressive Agents; Liver Cirrhosis; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Mice; Mice, Inbred NZB; Multiple Sclerosis; Nephritis; Nephrosis; Nitrogen Mustard Compounds; Penicillins; Psoriasis; Uveitis, Anterior | 1973 |
[Amyloidosis in chronic rheumatic diseases].
Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Biopsy; Chloroquine; Chronic Disease; Collagen Diseases; Felty Syndrome; Female; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Proteinuria; Psoriasis; Rectum; Rheumatic Diseases; Sjogren's Syndrome; Spondylitis, Ankylosing | 1968 |
Immunosuppressive drugs in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Mechlorethamine; Mercaptopurine; Methotrexate; Prednisolone; Pregnancy | 1969 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Cystitis; Female; Herpes Zoster; Humans; Jaundice; Mechlorethamine; Mercaptopurine; Methotrexate | 1970 |
[Immunosuppresive therapy of progredient chronic polyarthritis using antimetabolites and cytostatics].
Topics: Adrenal Cortex Hormones; Antigen-Antibody Reactions; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; Humans; Immunosuppressive Agents; Injections, Intra-Arterial; Leukocyte Count; Methotrexate; Purines; Rheumatoid Factor; Thiotepa | 1967 |
[Treatment of chronic diseases of connective tissue by cytostatic drugs].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Methotrexate; Spondylitis, Ankylosing; Thiotepa; Triaziquone | 1970 |
1337 trial(s) available for methotrexate and Rheumatoid Arthritis
| Article | Year |
|---|---|
Predictors of response to etanercept-methotrexate treatment: a post hoc logistic regression analysis of a randomized, open-label study in Latin American patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Latin America; Logistic Models; Methotrexate; Middle Aged; Treatment Outcome | 2021 |
SM03, an anti-human CD22 monoclonal antibody, for active rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Sialic Acid Binding Ig-like Lectin 2; Treatment Outcome | 2022 |
Radiographic Progression of Structural Joint Damage Over 5 Years of Baricitinib Treatment in Patients With Rheumatoid Arthritis: Results From RA-BEYOND.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2022 |
Comparison between leflunomide and sulfasalazine based triple therapy in methotrexate refractory rheumatoid arthritis: an open-label, non-inferiority randomized controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Sulfasalazine; Treatment Outcome | 2022 |
Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis.
Topics: Adult; Arthritis, Rheumatoid; Clostridium; Drugs, Chinese Herbal; Female; Gastrointestinal Microbiome; Humans; Leflunomide; Male; Methotrexate; Middle Aged | 2021 |
Observation of the curative effect of Guizhi-Shaoyao-Zhimu decoction combined with methotrexate in the treatment of early rheumatoid arthritis based on ultrasonic evaluation: study protocol of a randomized, double-blind, controlled clinical trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drugs, Chinese Herbal; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome; Ultrasonics | 2021 |
Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Female; Gene Expression; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; RNA, Long Noncoding; Sulfonamides; Tumor Necrosis Factor-alpha | 2021 |
Undifferentiated arthritis: a changing population who did not benefit from enhanced disease-modifying anti-rheumatic drug strategies-results from a 25 year longitudinal inception cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2022 |
Inhibition of structural joint damage progression with upadacitinib in rheumatoid arthritis: 1-year outcomes from the SELECT phase 3 program.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Efficacy and safety of abatacept in biologic-naïve patients with active rheumatoid arthritis by background methotrexate dose: post hoc analysis of a randomized, placebo-controlled, phase 4 study.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1).
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Finches; Humans; Japan; Methotrexate; Pyridines; Treatment Outcome; Triazoles | 2022 |
Efficacy and safety of filgotinib alone and in combination with methotrexate in Japanese patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 3)
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Finches; Humans; Japan; Methotrexate; Pyridines; Treatment Outcome; Triazoles | 2022 |
Immunogenicity of sarilumab and impact on safety and efficacy in Japanese patients with rheumatoid arthritis: analysis of two Phase 3 randomised clinical trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Japan; Methotrexate; Treatment Outcome | 2022 |
The impact of filgotinib on patient-reported outcomes and health-related quality of life for patients with active rheumatoid arthritis: a post hoc analysis of Phase 3 studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Patient Reported Outcome Measures; Pyridines; Quality of Life; Treatment Outcome; Triazoles | 2022 |
Discontinuation of methotrexate in rheumatoid arthritis patients achieving clinical remission by treatment with upadacitinib plus methotrexate (DOPPLER study): A study protocol for an interventional, multicenter, open-label and single-arm clinical trial w
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Multicenter Studies as Topic; Recurrence; Remission Induction; Treatment Outcome | 2022 |
Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial.
Topics: Adult; Antibodies, Neutralizing; Antibodies, Viral; Arthritis, Rheumatoid; COVID-19; COVID-19 Vaccines; Humans; Immunoglobulin G; Methotrexate; Prospective Studies; SARS-CoV-2; Withholding Treatment | 2022 |
Impact of Tofacitinib on Components of the ACR Response Criteria: Post Hoc Analysis of Phase III and Phase IIIb/IV Trials.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Treatment Outcome; United States | 2022 |
Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin-2; Methotrexate; Treatment Outcome | 2022 |
Achieving pain control in early rheumatoid arthritis with baricitinib monotherapy or in combination with methotrexate versus methotrexate monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Double-Blind Method; Humans; Methotrexate; Pain; Purines; Pyrazoles; Quality of Life; Sulfonamides; Treatment Outcome | 2022 |
Post hoc analysis of clinical characteristics of patients with radiographic progression in a Japanese phase 3 trial of peficitinib and methotrexate treatment (RAJ4).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; East Asian People; Humans; Methotrexate; Prednisolone; Treatment Outcome | 2023 |
The impact of tofacitinib on fatigue, sleep, and health-related quality of life in patients with rheumatoid arthritis: a post hoc analysis of data from Phase 3 trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Sleep; Treatment Outcome | 2022 |
Pharmacokinetics, pharmacodynamics, and safety of single-dose subcutaneous sarilumab with or without methotrexate in Japanese patients with rheumatoid arthritis: Two single-dose studies.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; East Asian People; Humans; Methotrexate; Treatment Outcome | 2023 |
Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prednisolone; Treatment Outcome | 2022 |
The Efficacy of Short-Term Bridging Strategies With High- and Low-Dose Prednisolone on Radiographic and Clinical Outcomes in Active Early Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prednisolone; Treatment Outcome | 2022 |
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis: Emulating a Randomized Trial in Observational Data.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Infliximab; Methotrexate; Sulfasalazine; Treatment Outcome | 2022 |
Efficacy and safety of HLX01 in patients with moderate-to-severe rheumatoid arthritis despite methotrexate therapy: a phase 3 study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Rituximab; Treatment Outcome | 2022 |
Phase II/III Results of a Trial of Anti-Tumor Necrosis Factor Multivalent NANOBODY Compound Ozoralizumab in Patients With Rheumatoid Arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Patient-reported outcomes of upadacitinib versus abatacept in patients with rheumatoid arthritis and an inadequate response to biologic disease-modifying antirheumatic drugs: 12- and 24-week results of a phase 3 trial.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Middle Aged; Pain; Patient Reported Outcome Measures; Quality of Life; Treatment Outcome | 2022 |
Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.
Topics: Adult; Arthritis, Rheumatoid; COVID-19; COVID-19 Vaccines; Female; Humans; Immunization, Secondary; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2022 |
Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: a machine learning approach using clinical trial data.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Machine Learning; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2022 |
Serum 14-3-3η as predictor of clinical remission and progression of structural damage in early rheumatoid arthritis following a treat-to-target strategy in a randomized controlled trial.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Humans; Methotrexate | 2023 |
Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.
Topics: Adult; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Cost of Illness; Double-Blind Method; Humans; Inflammation; Methotrexate; Treatment Outcome | 2022 |
Safety and efficacy of filgotinib for Japanese patients with RA and inadequate response to MTX: FINCH 1 52-week results and FINCH 4 48-week results.
Topics: Adalimumab; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; East Asian People; Humans; Janus Kinase 1; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2023 |
Long-term safety and efficacy of filgotinib treatment for rheumatoid arthritis in Japanese patients naïve to MTX treatment (FINCH 3).
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; East Asian People; Humans; Methotrexate; Treatment Outcome | 2023 |
A Multicenter, Prospective, Randomized, Parallel-Group Trial on the Effects of Temporary Methotrexate Discontinuation for One Week Versus Two Weeks on Seasonal Influenza Vaccination in Patients With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Methotrexate; Prospective Studies; Seasons; Vaccination | 2023 |
Olokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Association between low hemoglobin, clinical measures, and patient-reported outcomes in patients with rheumatoid arthritis: results from post hoc analyses of three phase III trials of sarilumab.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Hemoglobins; Humans; Methotrexate; Patient Reported Outcome Measures; Treatment Outcome | 2022 |
Impact of initial therapy with upadacitinib or adalimumab on achievement of 48-week treatment goals in patients with rheumatoid arthritis: post hoc analysis of SELECT-COMPARE.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Goals; Humans; Methotrexate; Treatment Outcome | 2023 |
Efficacy and tolerability of subcutaneously administered methotrexate including dose escalation in long-term treatment of rheumatoid arthritis in a Japanese population.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; East Asian People; Humans; Methotrexate; Treatment Outcome | 2023 |
Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled pha
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
Efficacy and safety of the anti-TNF multivalent NANOBODY® compound ozoralizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: A 52-week result of a Phase II/III study (OHZORA trial).
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Efficacy and safety of anti-TNF multivalent NANOBODY® compound 'ozoralizumab' without methotrexate co-administration in patients with active rheumatoid arthritis: A 52-week result of phase III, randomised, open-label trial (NATSUZORA trial).
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Favourable effect of a 'second hit' after 13 weeks in early RA non-responders: the Amsterdam COBRA treat-to-target randomized trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone; Sulfasalazine; Treatment Outcome | 2023 |
Combination of Methotrexate and Leflunomide Is Efficient and Safe for 60 Patients with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Humans; Interleukin-1; Interleukin-10; Leflunomide; Methotrexate; Rheumatoid Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Investigation on the Inhibitory Effect of Methotrexate on Rheumatoid Synovitis via the TLR4-NF-
Topics: Animals; Arthritis, Rheumatoid; Inflammation; Methotrexate; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Synovitis; Toll-Like Receptor 4; Water | 2022 |
Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Calcitriol; Collagen; Cytokines; Humans; Immunologic Factors; Immunotherapy; Liposomes; Methotrexate; NF-kappa B; Peptides; Receptors, Antigen, T-Cell; Receptors, CCR7 | 2022 |
Haemoglobin changes and disease activity in Japanese patients with rheumatoid arthritis treated with sarilumab.
Topics: Adult; Anemia; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; East Asian People; Female; Hemoglobins; Humans; Male; Methotrexate; Treatment Outcome | 2023 |
Cachexia measured by bioelectrical impedance vector analysis and risk of infection in women with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Body Composition; Cachexia; Electric Impedance; Female; Humans; Methotrexate | 2023 |
Reducing cardiovascular risk with immunomodulators: a randomised active comparator trial among patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arteritis; Arthritis, Rheumatoid; Cardiovascular Diseases; Female; Heart Disease Risk Factors; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2023 |
Effects of Disease-Worsening Following Withdrawal of Etanercept or Methotrexate on Patient-Reported Outcomes in Patients With Rheumatoid Arthritis: Results From the SEAM-RA Trial.
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Patient Reported Outcome Measures; Treatment Outcome | 2023 |
Relative Impact of Pain and Disease Activity on Improvements in Fatigue: Results From 2 Baricitinib Phase 3 Clinical Trials.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Fatigue; Humans; Methotrexate; Pain; Treatment Outcome | 2023 |
Efficacy and Safety of ABBV-3373, a Novel Anti-Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody-Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Control
Topics: Adalimumab; Adult; Anaphylaxis; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Glucocorticoids; Humans; Methotrexate; Necrosis; Pharmaceutical Preparations; Receptors, Glucocorticoid; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Efficacy, safety, and cost-effectiveness of triple therapy in preventing relapse in rheumatoid arthritis: A randomized controlled trial (ESCoRT study).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate; Recurrence; Treatment Outcome | 2022 |
Pharmacokinetics of oral and subcutaneous methotrexate in red and white blood cells in patients with early rheumatoid arthritis: the methotrexate monitoring trial.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Leukocytes; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Prospective Studies | 2023 |
Baseline serum levels of cross-linked carboxy-terminal telopeptide of type I collagen predict abatacept treatment response in methotrexate-naive, anticitrullinated protein antibody-positive patients with early rheumatoid arthritis.
Topics: Abatacept; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Collagen Type I; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
In Contrast to Anti-CCP, MMP-Degraded and Citrullinated Vimentin (VICM) Is Both a Diagnostic and a Treatment Response Biomarker.
Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Humans; Methotrexate; Peptides, Cyclic; Vimentin | 2022 |
Effectiveness of Yishen Tongbi decoction versus methotrexate in patients with active rheumatoid arthritis: A double-blind, randomized, controlled, non-inferiority trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2023 |
Efficacy and safety of selective JAK 1 inhibitor filgotinib in active rheumatoid arthritis patients with inadequate response to methotrexate: comparative study with filgotinib and tocilizumab examined by clinical index as well as musculoskeletal ultrasoun
Topics: Arthritis, Rheumatoid; Cytokines; Equivalence Trials as Topic; Humans; Interleukin-6; Janus Kinases; Methotrexate; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Signal Transduction; STAT Transcription Factors | 2023 |
Adalimumab combined with methotrexate versus adalimumab monotherapy in psoriasis: Three-year follow-up data of a single-blind randomized controlled trial.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Psoriasis; Single-Blind Method; Treatment Outcome | 2023 |
The trajectory of clinical responses in patients with early rheumatoid arthritis who achieve sustained remission in response to abatacept: subanalysis of AVERT-2, a randomized phase IIIb study.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2023 |
Single-cell RNA transcriptomic and plasma Lipidomic reveal the potential mechanisms of a Methotrexate-based therapy against Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Leukocytes, Mononuclear; Lipidomics; Lipids; Methotrexate; Transcriptome; Treatment Outcome | 2023 |
Ultrasound-Targeted Microbubble Destruction-Mediated Cell-Mimetic Nanodrugs for Treating Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Methotrexate; Microbubbles; Nanoparticles | 2023 |
Sustained remission following the discontinuation of tofacitinib in patients with rheumatoid arthritis (XANADU study): an open-label randomised study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Piperidines | 2023 |
Efficacy of certolizumab pegol across baseline rheumatoid factor subgroups in patients with rheumatoid arthritis: Post-hoc analysis of clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Rheumatoid Factor; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Irreversible covalent Bruton's tyrosine kinase inhibitor, TAS5315 versus placebo in rheumatoid arthritis patients with inadequate response to methotrexate: a randomised, double-blind, phase IIa trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tyrosine Kinase Inhibitors | 2023 |
Safety profile of upadacitinib in patients at risk of cardiovascular disease: integrated post hoc analysis of the SELECT phase III rheumatoid arthritis clinical programme.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Treatment Outcome; Venous Thromboembolism | 2023 |
Tofacitinib versus methotrexate as the first-line disease-modifying antirheumatic drugs in the treatment of rheumatoid arthritis: An open-label randomized controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2023 |
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2023 |
Safety and efficacy of mesenchymal stem cells therapy in the treatment of rheumatoid arthritis disease: A systematic review and meta-analysis of clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2023 |
The MIDORA trial: a phase II, randomised, double-blind, placebo-controlled, mechanistic insight and dosage optimisation study of the efficacy and safety of dazodalibep in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Immunologic Factors; Methotrexate; Rheumatoid Factor | 2023 |
Network pharmacology analysis and clinical verification of Jishe Qushi capsules in rheumatoid arthritis treatment.
Topics: Arthritis, Rheumatoid; Capsules; Humans; Methotrexate; Molecular Docking Simulation; Network Pharmacology; PPAR gamma; Quality of Life | 2023 |
Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3).
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Methotrexate; Severity of Illness Index; Treatment Outcome | 2023 |
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Humans; Methotrexate; Pyrroles; Randomized Controlled Trials as Topic; Treatment Outcome | 2023 |
Efficacy and safety of different Janus kinase inhibitors combined with methotrexate for the treatment of rheumatoid arthritis: a single-center randomized trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Pain; Retrospective Studies | 2023 |
[Mechanism of Qingluo Tongbi Formula for regulating immune-bone erosion in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Drugs, Chinese Herbal; Humans; Methotrexate; Osteoclasts; Osteoprotegerin; RANK Ligand; Tartrate-Resistant Acid Phosphatase | 2023 |
Discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab: An interventional study.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged | 2020 |
Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age.
Topics: Age Factors; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2019 |
Effect of disease duration and prior disease-modifying antirheumatic drug use on treatment outcomes in patients with rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Long-term safety and efficacy of sarilumab plus methotrexate on disease activity, physical function and radiographic progression: 5 years of sarilumab plus methotrexate treatment.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Exercise; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Neutrophils; Patient Safety; Placebos; Radiography; Receptors, Interleukin-6; Treatment Outcome | 2019 |
Baseline Objective Inflammation by Magnetic Resonance Imaging as a Predictor of Therapeutic Benefit in Early Rheumatoid Arthritis With Poor Prognosis.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Inflammation; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prognosis; Treatment Outcome | 2020 |
Observation of the clinical effect of the combined therapy of zushima tablet and western medicine in the treatment of rheumatoid arthritis and MRI test results.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Naproxen; Prednisolone; Sulfasalazine; Tablets; Treatment Outcome; Western World | 2019 |
Differences in disease activity measures in patients with rheumatoid arthritis who achieved DAS, SDAI, or CDAI remission but not Boolean remission.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Remission Induction; Severity of Illness Index | 2020 |
An open-label randomized controlled trial of DMARD withdrawal in RA patients achieving therapeutic response with certolizumab pegol combined with DMARDs.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Deprescriptions; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Tumor Necrosis Factor Inhibitors | 2020 |
Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Piperidines; Predictive Value of Tests; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Patient-reported outcomes for tofacitinib with and without methotrexate, or adalimumab with methotrexate, in rheumatoid arthritis: a phase IIIB/IV trial.
Topics: Adalimumab; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2019 |
Predictors of good response to conventional synthetic DMARDs in early seronegative rheumatoid arthritis: data from the ESPOIR cohort.
Topics: Adult; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Middle Aged; Prognosis; Rheumatoid Factor; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2019 |
Effect of short-term methotrexate discontinuation on rheumatoid arthritis disease activity: post-hoc analysis of two randomized trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Deprescriptions; Drug Administration Schedule; Humans; Methotrexate; Symptom Flare Up | 2020 |
FKB327, an adalimumab biosimilar, versus the reference product: results of a randomized, Phase III, double-blind study, and its open-label extension.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Safety and efficacy of tocilizumab as monotherapy or in combination with methotrexate in Tunisian patients with active rheumatoid arthritis and inadequate response to disease-modifying anti-rheumatic drugs in conditions close to clinical practice.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Tunisia | 2020 |
Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2020 |
Methotrexate pharmacokinetic is influenced by co-administration of cyclosporin in rheumatoid arthritis patients. Results from a randomized clinical trial.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Administration Schedule; Early Diagnosis; Erythrocytes; Female; Glomerular Filtration Rate; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2020 |
Evaluating the therapeutic efficacy of the Chinese herbal medicine Yishen Tongbi decoction in patients with active rheumatoid arthritis: protocol for a randomized, controlled, noninferiority trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Treatment Outcome; Young Adult | 2019 |
Pharmacological conditioning in the treatment of recent-onset rheumatoid arthritis: a randomized controlled trial study protocol.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Conditioning, Psychological; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Equivalence Trials as Topic; Humans; Methotrexate; Multicenter Studies as Topic; Netherlands; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome; Young Adult | 2020 |
Long-term Efficacy, Safety, and Immunogenicity of the Infliximab (IFX) Biosimilar, PF-06438179/GP1111, in Patients with Rheumatoid Arthritis After Switching from Reference IFX or Continuing Biosimilar Therapy: Week 54-78 Data From a Randomized, Double-Bli
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Safety; Therapeutic Equivalency | 2020 |
Factors associated with successful discontinuation of certolizumab pegol in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Remission Induction; Time Factors; Treatment Outcome | 2020 |
Methotrexate effect on immunogenicity and long-term maintenance of adalimumab in axial spondyloarthritis: a multicentric randomised trial.
Topics: Adalimumab; Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Prospective Studies; Spondylarthritis; Treatment Outcome; Young Adult | 2020 |
Pragmatic randomised controlled trial of very early etanercept and MTX versus MTX with delayed etanercept in RA: the VEDERA trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Medical Intervention; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Treatment Outcome | 2020 |
Pharmacokinetic Similarity and Comparative Pharmacodynamics, Safety, Efficacy, and Immunogenicity of DRL_RI Versus Reference Rituximab in Biologics-Naïve Patients with Moderate-to-Severe Rheumatoid Arthritis: A Double-Blind, Randomized, Three-Arm Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Safety; Therapeutic Equivalency; Young Adult | 2020 |
A phase 2a, randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral gonadotropin-releasing hormone antagonist, ASP1707, in postmenopausal female patients with rheumatoid arthritis taking methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Gonadotropin-Releasing Hormone; Humans; Imidazoles; Methotrexate; Middle Aged; Postmenopause; Sulfones; Treatment Outcome | 2021 |
Safety and effectiveness of peficitinib (ASP015K) in patients with rheumatoid arthritis: interim data (22.7 months mean peficitinib treatment) from a long-term, open-label extension study in Japan, Korea, and Taiwan.
Topics: Adamantane; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Herpes Zoster; Humans; Janus Kinase Inhibitors; Japan; Male; Methotrexate; Middle Aged; Nasopharyngitis; Niacinamide; Republic of Korea; Severity of Illness Index; Taiwan; Treatment Outcome | 2020 |
Effect of adjuvant therapy with electroacupuncture on bone turnover markers and interleukin 17 in patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; C-Reactive Protein; Combined Modality Therapy; Electroacupuncture; Female; Humans; Interleukin-17; Leflunomide; Male; Methotrexate; Middle Aged; Quality of Life; Treatment Outcome | 2019 |
Glucose-6-phosphate isomerase is associated with disease activity and declines in response to infliximab treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Enzyme-Linked Immunosorbent Assay; Female; Glucose-6-Phosphate Isomerase; Humans; Infliximab; Male; Methotrexate; Middle Aged; Young Adult | 2020 |
Two-year cost-effectiveness of different COBRA-like intensive remission induction schemes in early rheumatoid arthritis: a piggyback study on the pragmatic randomised controlled CareRA trial.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Leflunomide; Male; Methotrexate; Middle Aged; Pain Measurement; Quality-Adjusted Life Years; Range of Motion, Articular; Remission Induction; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Sulfasalazine; Time Factors; Treatment Outcome | 2020 |
Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
Topics: Aged; Amino Acid Substitution; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Mutation, Missense; Organic Anion Transporters; Polymorphism, Single Nucleotide | 2020 |
Long-term safety, immunogenicity and efficacy comparing FKB327 with the adalimumab reference product in patients with active rheumatoid arthritis: data from randomised double-blind and open-label extension studies.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2020 |
One in five patients with rapidly and persistently controlled early rheumatoid arthritis report poor well-being after 1 year of treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Female; Humans; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Patient Reported Outcome Measures; Quality of Life; Recovery of Function; Severity of Illness Index; Treatment Outcome | 2020 |
Population Pharmacokinetic-Pharmacodynamic Relationships of Sarilumab Using Disease Activity Score 28-Joint C-Reactive Protein and Absolute Neutrophil Counts in Patients with Rheumatoid Arthritis.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Male; Methotrexate; Middle Aged; Neutrophils; Treatment Outcome | 2020 |
Earlier is better when treating rheumatoid arthritis: but can we detect a window of opportunity?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Methotrexate; Middle Aged; Netherlands; Prednisone; Proportional Hazards Models; Remission Induction; Time Factors; Time-to-Treatment; Treatment Outcome | 2020 |
Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Severity of Illness Index; Single-Blind Method; Symptom Flare Up; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Withholding Treatment | 2020 |
Efficacy and safety of sarilumab in combination with csDMARDs or as monotherapy in subpopulations of patients with moderately to severely active rheumatoid arthritis in three phase III randomized, controlled studies.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2020 |
Investigation of Potential Drug-Drug Interactions between Peficitinib (ASP015K) and Methotrexate in Patients with Rheumatoid Arthritis.
Topics: Adamantane; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Drug Interactions; Female; Half-Life; Humans; Male; Methotrexate; Middle Aged; Niacinamide | 2020 |
Efficacy and safety of low-dose glucocorticoids combined with methotrexate and hydroxychloroquine in the treatment of early rheumatoid arthritis: A single-center, randomized, double-blind clinical trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Quality of Life; Severity of Illness Index | 2020 |
Efficacy and safety of Sandoz biosimilar rituximab for active rheumatoid arthritis: 52-week results from the randomized controlled ASSIST-RA trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Rituximab; Therapeutic Equivalency; Time Factors | 2021 |
Leflunomide monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a retrospective study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies | 2020 |
Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single-Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate.
Topics: Administration, Intravenous; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Half-Life; Humans; Injections, Subcutaneous; Interleukin-6; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neutrophils | 2021 |
A patient-initiated DMARD self-monitoring service for people with rheumatoid or psoriatic arthritis: a cost-effectiveness analysis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Monitoring; Health Care Costs; Humans; Methotrexate; National Health Programs; Outcome Assessment, Health Care; Practice Patterns, Nurses'; Quality of Life; Uncertainty; United Kingdom | 2021 |
Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cells; Female; Humans; Male; Methotrexate; Middle Aged; Transcriptome | 2020 |
Vitamin D: does it help Tregs in active rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Ergocalciferols; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; T-Lymphocytes, Regulatory | 2020 |
Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Blood Sedimentation; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Remission Induction; Severity of Illness Index; Treatment Outcome | 2020 |
Cardiovascular effects of biological versus conventional synthetic disease-modifying antirheumatic drug therapy in treatment-naïve, early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Etanercept; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Risk Factors; Treatment Outcome; Vascular Stiffness | 2020 |
Efficacy of methotrexate and etanercept biosimilar rhTNFR:Fc in Chinese patients with active rheumatoid arthritis: A controlled, randomized and multicenter study.
Topics: Adult; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Treatment Outcome | 2020 |
Weekly split-dose regimen for oral methotrexate reduced polyglutamation in red blood cells in patients with rheumatoid arthritis compared with single-dose regimen: Results from a multicentered randomized control trial.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Treatment Outcome | 2020 |
The multi-biomarker disease activity test for assessing response to treatment strategies using methotrexate with or without prednisone in the CAMERA-II trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Prednisone; Severity of Illness Index; Treatment Outcome | 2020 |
Interleukin-6 receptor blockade or TNFα inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus; Humans; Methotrexate; Prospective Studies; Receptors, Interleukin-6; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
Efficacy and Safety of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients With Active Rheumatoid Arthritis With Inadequate Response to Methotrexate: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Study.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Retreatment; Treatment Outcome | 2021 |
The Janus kinase 1/2 inhibitor baricitinib reduces biomarkers of joint destruction in moderate to severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Biomarkers; Humans; Janus Kinase 1; Methotrexate; Purines; Pyrazoles; Sulfonamides | 2020 |
ASP5094, a humanized monoclonal antibody against integrin alpha-9, did not show efficacy in patients with rheumatoid arthritis refractory to methotrexate: results from a phase 2a, randomized, double-blind, placebo-controlled trial.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Integrins; Methotrexate; Treatment Outcome | 2020 |
Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Treatment Outcome; Venous Thromboembolism | 2021 |
Switching between Janus kinase inhibitor upadacitinib and adalimumab following insufficient response: efficacy and safety in patients with rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Treatment Outcome | 2021 |
Upadacitinib monotherapy versus methotrexate monotherapy in methotrexate-naïve Japanese patients with rheumatoid arthritis: a sub-analysis of the Phase 3 SELECT-EARLY study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Heterocyclic Compounds, 3-Ring; Humans; Japan; Male; Methotrexate; Middle Aged; Treatment Outcome | 2021 |
Efficacy of baricitinib in patients with moderate-to-severe rheumatoid arthritis with 3 years of treatment: results from a long-term study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2021 |
Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Deprescriptions; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Remission Induction | 2021 |
Safety and efficacy of fostamatinib in rheumatoid arthritis patients with an inadequate response to methotrexate in phase II OSKIRA-ASIA-1 and OSKIRA-ASIA-1X study.
Topics: Aged; Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Asia; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Morpholines; Oxazines; Pyridines; Pyrimidines | 2021 |
Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial.
Topics: Abatacept; Adult; Aged; Anti-Citrullinated Protein Antibodies; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; C-Reactive Protein; Certolizumab Pegol; Denmark; Drug Therapy, Combination; Early Medical Intervention; Female; Finland; Glucocorticoids; Humans; Hydroxychloroquine; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Netherlands; Norway; Prednisolone; Rheumatoid Factor; Severity of Illness Index; Single-Blind Method; Sulfasalazine; Sweden; Treatment Outcome | 2020 |
Efficacy and safety of filgotinib in Japanese patients with refractory rheumatoid arthritis: Subgroup analyses of a global phase 3 study (FINCH 2).
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Finches; Humans; Japan; Methotrexate; Pyridines; Treatment Outcome; Triazoles | 2022 |
Comprehensive exploratory autoantibody profiling in patients with early rheumatoid arthritis treated with methotrexate or tocilizumab.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Double-Blind Method; Female; Histone-Lysine N-Methyltransferase; Humans; Immunoglobulin G; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Nerve Tissue Proteins; Neuro-Oncological Ventral Antigen; Peptide Termination Factors; RNA-Binding Proteins; Tropomyosin | 2020 |
Upadacitinib monotherapy improves patient-reported outcomes in rheumatoid arthritis: results from SELECT-EARLY and SELECT-MONOTHERAPY.
Topics: Activities of Daily Living; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Efficiency; Fatigue; Female; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Least-Squares Analysis; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Reported Outcome Measures; Quality of Life; Work | 2021 |
Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry.
Topics: Aged; Arthritis, Rheumatoid; Azetidines; Female; Follow-Up Studies; Humans; Japan; Male; Methotrexate; Middle Aged; Prednisolone; Purines; Pyrazoles; Retrospective Studies; Sulfonamides | 2020 |
Safety and Efficacy of Poseltinib, Bruton's Tyrosine Kinase Inhibitor, in Patients With Rheumatoid Arthritis: A Randomized, Double-blind, Placebo-controlled, 2-part Phase II Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Protein Kinase Inhibitors; Severity of Illness Index; Treatment Outcome | 2021 |
Upadacitinib tartrate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Tartrates | 2020 |
Efficacy, Safety, and Immunogenicity of Biosimilar Etanercept (Enerceptan) Versus Its Original Form in Combination With Methotrexate in Patients With Rheumatoid Arthritis: A Randomized, Multicenter, Evaluator-Blinded, Noninferiority Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Treatment Outcome | 2021 |
Similar lipid level changes in early rheumatoid arthritis patients following 1-year treat-to-target strategy with adalimumab plus methotrexate versus placebo plus methotrexate: secondary analyses from the randomised controlled OPERA trial.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Methotrexate | 2021 |
Efficacy and safety of upadacitinib over 84 weeks in Japanese patients with rheumatoid arthritis (SELECT-SUNRISE).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Japan; Methotrexate; Treatment Outcome | 2021 |
Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Connective Tissue; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2021 |
Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Finches; Humans; Methotrexate; Pyridines; Treatment Outcome; Triazoles | 2021 |
Patient-reported outcomes data in patients with psoriatic arthritis from a randomised trial of etanercept and methotrexate as monotherapy or in combination.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Etanercept; Humans; Methotrexate; Patient Reported Outcome Measures | 2021 |
Long-term effects on bone mineral density after four years of treatment with two intensive combination strategies, including initially high-dose prednisolone, in early rheumatoid arthritis patients: the COBRA-light trial.
Topics: Absorptiometry, Photon; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone | 2021 |
Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Pyridines; Triazoles | 2021 |
Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Male; Methotrexate; Pyridines; Treatment Outcome; Triazoles | 2021 |
Current Smoking Negatively Affects the Response to Methotrexate in Rheumatoid Arthritis in a Dose-responsive Way, Independently of Concomitant Prednisone Use.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prednisone; Smoking; Treatment Outcome | 2021 |
The efficacy, safety and cost-effectiveness of hydroxychloroquine, sulfasalazine, methotrexate triple therapy in preventing relapse among patients with rheumatoid arthritis achieving clinical remission or low disease activity: the study protocol of a rand
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Neoplasm Recurrence, Local; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2021 |
The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial.
Topics: Adjuvants, Immunologic; Adult; AMP-Activated Protein Kinases; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Double-Blind Method; Female; Humans; Male; Metformin; Methotrexate; Middle Aged; Treatment Outcome | 2021 |
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Lipidomics; Lipids; Male; Methotrexate; Middle Aged; Prospective Studies | 2021 |
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Symptom Flare Up; Ultrasonography | 2021 |
Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; Certolizumab Pegol; CTLA-4 Antigen; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Programmed Cell Death 1 Receptor; Young Adult | 2022 |
Efficacy of Bi Qi Capsules in combination with methotrexate in the treatment of rheumatoid arthritis: A protocol of double-blind randomized controlled trial.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Capsules; Double-Blind Method; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Young Adult | 2021 |
Short-term glucocorticoids reduce risk of chronic NSAID and analgesic use in early methotrexate-treated rheumatoid arthritis patients with favourable prognosis: subanalysis of the CareRA randomised controlled trial.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate | 2021 |
A double-blind, double-dummy, randomized controlled, multicenter trial of 99Tc-methylene diphosphonate in patients with moderate to severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Diphosphonates; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Technetium; Treatment Outcome | 2021 |
Serum TNFα levels at 24 h after certolizumab pegol predict effectiveness at week 12 in patients with rheumatoid arthritis from TSUBAME study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2021 |
Efficacy and safety of tofacitinib modified-release 11 mg once daily plus methotrexate in adult patients with rheumatoid arthritis: 24-week open-label phase results from a phase 3b/4 methotrexate withdrawal non-inferiority study (ORAL Shift).
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Piperidines; Pyrimidines; Treatment Outcome | 2021 |
Comparison of two dose escalation strategies of methotrexate in active rheumatoid arthritis: a multicentre, parallel group, randomised controlled trial.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Thrombocytopenia; Treatment Outcome; Young Adult | 2021 |
Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Proof of Concept Study; Purinergic P2Y Receptor Antagonists; Severity of Illness Index; Ticagrelor | 2021 |
Comparative study evaluating antihistamine versus leukotriene receptor antagonist as adjuvant therapy for rheumatoid arthritis.
Topics: Acetates; Adult; Arthritis, Rheumatoid; Body Mass Index; C-Reactive Protein; Clusterin; Cyclopropanes; Cyproheptadine; Double-Blind Method; Drug Therapy, Combination; E-Selectin; Egypt; Female; Histamine Antagonists; Humans; Immunosuppressive Agents; Interleukins; Leukotriene Antagonists; Male; Methotrexate; Middle Aged; Quinolines; Sulfides | 2021 |
Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prospective Studies; Tacrolimus; Treatment Outcome; Tumor Necrosis Factor-alpha | 2021 |
Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Endothelial Cells; Female; Humans; Male; Matrix Metalloproteinase 9; Methotrexate; Middle Aged; Prospective Studies; Syndecan-1; Tissue Inhibitor of Metalloproteinase-1; Treatment Outcome; Young Adult | 2021 |
Comparison of the efficacy and safety of LBAL, a candidate adalimumab biosimilar, and adalimumab reference product in patients with active rheumatoid arthritis inadequately responding to methotrexate: a 52-week phase III randomised study.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Humans; Methotrexate; Treatment Outcome | 2022 |
Pretreatment resistin levels are associated with erosive disease in early rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs and infliximab.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Inflammation; Infliximab; Methotrexate; Resistin; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Treatment Outcome | 2022 |
Efficacy and safety of filgotinib in methotrexate-naive patients with rheumatoid arthritis with poor prognostic factors: post hoc analysis of FINCH 3.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prognosis; Pyridines; Treatment Outcome; Triazoles | 2021 |
Patient- and physician-reported outcomes from two phase 3 randomized studies (RAJ3 and RAJ4) of peficitinib (ASP015K) in Asian patients with rheumatoid arthritis.
Topics: Adamantane; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Methotrexate; Niacinamide; Patient Reported Outcome Measures; Physicians; Treatment Outcome | 2021 |
Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Disability Evaluation; Double-Blind Method; Drug Partial Agonism; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydrocortisone; Joints; Male; Methotrexate; Middle Aged; Organophosphates; Phenanthrenes; Prednisone; Receptors, Glucocorticoid; Recovery of Function; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2017 |
Rheumatoid Arthritis Treatment After Methotrexate: The Durability of Triple Therapy Versus Etanercept.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Canada; Disability Evaluation; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Time Factors; Treatment Outcome; United States; Young Adult | 2017 |
Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Joints; Male; Medication Therapy Management; Methotrexate; Middle Aged; Radiography; Remission Induction; Treatment Outcome | 2017 |
Estimated medical expenditure and risk of job loss among rheumatoid arthritis patients undergoing tofacitinib treatment: post hoc analyses of two randomized clinical trials.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Double-Blind Method; Drug Therapy, Combination; Female; Health Expenditures; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Return to Work; Risk Factors; Treatment Outcome | 2017 |
Effect of methotrexate discontinuation on efficacy of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial.
Topics: Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Deprescriptions; Drug Administration Schedule; Female; Humans; Immunogenicity, Vaccine; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B virus; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Time Factors | 2017 |
Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bifidobacterium bifidum; Dietary Supplements; Double-Blind Method; Female; Humans; Hydroxychloroquine; Lacticaseibacillus casei; Lactobacillus acidophilus; Male; Methotrexate; Middle Aged; Prednisolone; Synbiotics | 2017 |
Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study.
Topics: Adolescent; Adult; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cell Differentiation; Cholecalciferol; Cytokines; Double-Blind Method; Female; Glucocorticoids; Humans; Immunologic Factors; Methotrexate; Middle Aged; Osteoclasts; Severity of Illness Index; T-Lymphocytes, Helper-Inducer; Treatment Outcome | 2017 |
Postmarketing surveillance evaluating the safety and effectiveness of golimumab in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing | 2018 |
Maintenance of remission with combination etanercept-DMARD therapy versus DMARDs alone in active rheumatoid arthritis: results of an international treat-to-target study conducted in regions with limited biologic access.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome | 2017 |
Soluble CD206 plasma levels in rheumatoid arthritis reflect decrease in disease activity.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Dendritic Cells; Female; Gene Expression; Humans; Lectins, C-Type; Macrophage Activation; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Methotrexate; Middle Aged; Receptors, Cell Surface; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK-1 Inhibitor, After Short-Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 1; Male; Methotrexate; Middle Aged; Pyridines; Treatment Outcome; Triazoles; Young Adult | 2017 |
Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial.
Topics: Adalimumab; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2017 |
A randomised, double-blind trial to demonstrate bioequivalence of GP2013 and reference rituximab combined with methotrexate in patients with active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Rituximab; Therapeutic Equivalency; Treatment Outcome; Vitamin B Complex; Young Adult | 2017 |
A disconnect between disease activity and functional ability already in patients with early rheumatoid arthritis, depending on large joint involvement.
Topics: Activities of Daily Living; Adult; Ankle Joint; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Elbow Joint; Female; Humans; Knee Joint; Male; Methotrexate; Middle Aged; Netherlands; Risk Assessment; Severity of Illness Index; Shoulder Joint; Treatment Outcome | 2018 |
A Phase III Study Evaluating Continuation, Tapering, and Withdrawal of Certolizumab Pegol After One Year of Therapy in Patients With Early Rheumatoid Arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Certolizumab Pegol; Deprescriptions; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Remission Induction | 2017 |
Leflunomide is equally efficacious and safe compared to low dose rituximab in refractory rheumatoid arthritis given in combination with methotrexate: results from a randomized double blind controlled clinical trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Lymphocytes; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome | 2017 |
Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Gene Regulatory Networks; Genotype; Humans; Methotrexate; Remission Induction; Transcriptome | 2017 |
Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Blood Sedimentation; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Severity of Illness Index; Sulfonamides; Treatment Outcome; Young Adult | 2018 |
Exposure-Response Modeling and Power Analysis of Components of ACR Response Criteria in Rheumatoid Arthritis (Part 2: Continuous Model).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Joints; Methotrexate; Models, Biological; Monte Carlo Method; Severity of Illness Index; Treatment Outcome | 2017 |
Exposure-Response Modeling and Power Analysis of Components of ACR Response Criteria in Rheumatoid Arthritis (Part 1: Binary Model).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Joints; Methotrexate; Models, Biological; Monte Carlo Method; Severity of Illness Index; Treatment Outcome | 2017 |
The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
Topics: Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Herpes Zoster; Herpes Zoster Vaccine; Herpesvirus 3, Human; Humans; Immunogenicity, Vaccine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; T-Lymphocytes | 2017 |
Similar efficacy and safety of initial COBRA-light and COBRA therapy in rheumatoid arthritis: 4-year results from the COBRA-light trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Severity of Illness Index; Sulfasalazine; Survival Analysis; Treatment Outcome | 2017 |
Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2017 |
A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Low Hemoglobin and Radiographic Damage Progression in Early Rheumatoid Arthritis: Secondary Analysis From a Phase III Trial.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Hemoglobins; Humans; Joints; Male; Methotrexate; Radiography | 2018 |
Rheumatoid arthritis patients with continued low disease activity have similar outcomes over 10 years, regardless of initial therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Linear Models; Male; Methotrexate; Middle Aged; Netherlands; Prednisone; Remission Induction; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome | 2017 |
Effects of psychosocial factors on monitoring treatment effect in newly diagnosed rheumatoid arthritis patients over time: response data from the tREACH study.
Topics: Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Depression; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Monitoring, Physiologic; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome | 2018 |
Clinical and radiological outcomes of 5-year drug-free remission-steered treatment in patients with early arthritis: IMPROVED study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Joints; Male; Methotrexate; Middle Aged; Prednisone; Radiography; Remission Induction; Severity of Illness Index; Single-Blind Method; Sulfasalazine; Time Factors; Treatment Outcome | 2018 |
Patient-reported outcomes in newly diagnosed early rheumatoid arthritis patients treated to target with a tocilizumab- or methotrexate-based strategy.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Early Diagnosis; Female; Humans; Male; Methotrexate; Middle Aged; Minimal Clinically Important Difference; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2017 |
Safety, immunogenicity and efficacy after switching from reference infliximab to biosimilar SB2 compared with continuing reference infliximab and SB2 in patients with rheumatoid arthritis: results of a randomised, double-blind, phase III transition study.
Topics: Adolescent; Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
CNTO6785, a Fully Human Antiinterleukin 17 Monoclonal Antibody, in Patients with Rheumatoid Arthritis with Inadequate Response to Methotrexate: A Randomized, Placebo-controlled, Phase II, Dose-ranging Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interleukin-17; Logistic Models; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
Radiographic joint damage in early rheumatoid arthritis patients: comparing tocilizumab- and methotrexate-based treat-to-target strategies.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Female; Foot; Hand; Humans; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2018 |
[Effect of Sanbitang recipe in treatment of rheumatoid arthritis with kidney empty and cold-dampness symptom].
Topics: Arthritis, Rheumatoid; Drugs, Chinese Herbal; Humans; Kidney; Medicine, Chinese Traditional; Methotrexate | 2017 |
[Janus kinase inhibitor baricitinib for rheumatoid arthritis : Randomized, double-blind, placebo- and active-controlled, phase 3 study evaluating the efficacy and safety of baricitinib in patients with moderately to severely active rheumatoid arthritis wh
Topics: Adalimumab; Administration, Oral; Adult; Arthritis, Rheumatoid; Azetidines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Janus Kinase Inhibitors; Male; Methotrexate; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2017 |
Plasma MicroRNA Profiles in Patients with Early Rheumatoid Arthritis Responding to Adalimumab plus Methotrexate vs Methotrexate Alone: A Placebo-controlled Clinical Trial.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Linear Models; Logistic Models; Male; Methotrexate; MicroRNAs; Middle Aged; Multivariate Analysis; Prospective Studies; Remission Induction; ROC Curve; Treatment Outcome; Young Adult | 2018 |
Effect of Glucocorticoids on the Clinical and Radiographic Efficacy of Tofacitinib in Patients with Rheumatoid Arthritis: A Posthoc Analysis of Data from 6 Phase III Studies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Health Surveys; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Testing treat-to-target outcomes with initial methotrexate monotherapy compared with initial tumour necrosis factor inhibitor (adalimumab) plus methotrexate in early rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Tofacitinib Therapy for Rheumatoid Arthritis: A Direct Comparison Study between Biologic-naïve and Experienced Patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome | 2018 |
Tapering versus steady-state methotrexate in combination with tocilizumab for rheumatoid arthritis: a randomized, double-blind trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Equivalence Trials as Topic; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2018 |
Defining and characterizing sustained remission in patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2018 |
[Long-snake moxibustion for rheumatoid arthritis:a randomized controlled trial].
Topics: Acupuncture Points; Acupuncture Therapy; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Methotrexate; Moxibustion; Treatment Outcome | 2016 |
Phase III, multicentre, double-blind, randomised, parallel-group study to evaluate the similarities between LBEC0101 and etanercept reference product in terms of efficacy and safety in patients with active rheumatoid arthritis inadequately responding to m
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Blood Sedimentation; Double-Blind Method; Etanercept; Female; Humans; Immunoglobulin G; Least-Squares Analysis; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Therapeutic Equivalency; Treatment Outcome; Young Adult | 2018 |
Onset of Hypertension in Leflunamide Treated Low Socioeconomic Rheumatoid Arthritis Patients: An Unseen Iceberg.
Topics: Adult; Arthritis, Rheumatoid; Asian People; Case-Control Studies; Female; Humans; Hypertension; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Middle Aged; Pakistan; Socioeconomic Factors | 2019 |
Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Recovery of Function; Remission Induction; Republic of Korea; Time Factors; Treatment Outcome; Young Adult | 2018 |
MRI assessment of erosion repair in patients with long-standing rheumatoid arthritis receiving double-filtration plasmapheresis in addition to leflunomide and methotrexate: a randomized controlled trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Humans; Isoxazoles; Joints; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Plasmapheresis; Treatment Outcome | 2018 |
Predictors of remission with etanercept-methotrexate induction therapy and loss of remission with etanercept maintenance, reduction, or withdrawal in moderately active rheumatoid arthritis: results of the PRESERVE trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2018 |
Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase IIb, randomised, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; CD4 Antigens; Double-Blind Method; Female; Humans; Immunoglobulin G; Immunomodulation; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
[Flipping moxibustion of
Topics: Acupuncture Points; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Meridians; Methotrexate; Moxibustion; Rheumatoid Factor; Sulfasalazine; Syndrome | 2017 |
Population Pharmacokinetics of the TNF-α and IL-17A Dual-Variable Domain Antibody ABT-122 in Healthy Volunteers and Subjects With Psoriatic or Rheumatoid Arthritis: Analysis of Phase 1 and 2 Clinical Trials.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Availability; Body Weight; Double-Blind Method; Female; Healthy Volunteers; Humans; Immunoglobulins; Interleukin-17; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Random Allocation; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Hand; Humans; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index; Treatment Outcome; Ultrasonography; Wrist | 2018 |
Methotrexate Dose in Patients With Early Rheumatoid Arthritis Impacts Methotrexate Polyglutamate Pharmacokinetics, Adalimumab Pharmacokinetics, and Efficacy: Pharmacokinetic and Exposure-response Analysis of the CONCERTO Trial.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Treatment Outcome | 2018 |
Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Drug Therapy, Combination; Female; Humans; Immunoglobulin Isotypes; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prednisone; Time Factors | 2018 |
Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Nasopharyngitis; Sulfasalazine; Treatment Outcome | 2018 |
The efficacy of the traditional Chinese medicine Juanbi pill combined with methotrexate in active rheumatoid arthritis: study protocol for a randomized controlled trial.
Topics: Adult; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Medicine, Chinese Traditional; Methotrexate; Multicenter Studies as Topic; Outcome Assessment, Health Care; Quality Control; Randomized Controlled Trials as Topic; Sample Size; Severity of Illness Index | 2018 |
Effect of filgotinib, a selective JAK 1 inhibitor, with and without methotrexate in patients with rheumatoid arthritis: patient-reported outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 1; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Protein Kinase Inhibitors; Pyridines; Treatment Outcome; Triazoles | 2018 |
Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial.
Topics: Adult; Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Betainfluenzavirus; Deprescriptions; Drug Administration Schedule; Female; Humans; Immunogenicity, Vaccine; Influenza A virus; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Prospective Studies; Seasons; Single-Blind Method; Vaccination; Young Adult | 2018 |
Sustained Response Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: Results From a Randomized, Controlled Trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Withholding Treatment | 2018 |
Regional differences in baseline disease activity and remission rates following golimumab treatment for RA: results from the GO-MORE trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2018 |
Comparison of the impact of Tripterygium wilfordii Hook F and Methotrexate treatment on radiological progression in active rheumatoid arthritis: 2-year follow up of a randomized, non-blinded, controlled study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Plant Extracts; Tripterygium | 2018 |
Evaluation of disease activity in patients with rheumatoid arthritis treated with tofacitinib by RAPID3: post hoc analyses from two phase 3 trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2018 |
Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb Trial.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2018 |
Two years of sarilumab in patients with rheumatoid arthritis and an inadequate response to MTX: safety, efficacy and radiographic outcomes.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome | 2018 |
Inadequate response to treat-to-target methotrexate therapy in patients with new-onset rheumatoid arthritis: development and validation of clinical predictors.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Remission Induction; Severity of Illness Index; Treatment Outcome | 2018 |
Effect of Treat-to-target Strategies Aiming at Remission of Arterial Stiffness in Early Rheumatoid Arthritis: A Randomized Controlled Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Pulse Wave Analysis; Remission Induction; Severity of Illness Index; Treatment Outcome; Vascular Stiffness | 2018 |
Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRIS
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Severity of Illness Index; Treatment Outcome | 2018 |
ABT-122, a Bispecific Dual Variable Domain Immunoglobulin Targeting Tumor Necrosis Factor and Interleukin-17A, in Patients With Rheumatoid Arthritis With an Inadequate Response to Methotrexate: A Randomized, Double-Blind Study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Immunoglobulins; Interleukin-17; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Azilsartan as "Add-On" Treatment with Methotrexate Improves the Disease Activity of Rheumatoid Arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Benzimidazoles; Cytokines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lipids; Male; Methotrexate; Middle Aged; Oxadiazoles; Pilot Projects | 2018 |
[Treatment of Rheumatoid Arthritis by Bee-venom Acupuncture].
Topics: Acupuncture Therapy; Animals; Arthritis, Rheumatoid; Bee Venoms; Bees; Hand Strength; Humans; Methotrexate; Treatment Outcome | 2018 |
Alternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Cost-Benefit Analysis; Disability Evaluation; Equivalence Trials as Topic; Female; Health Status; Humans; Male; Mental Health; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Rituximab; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2018 |
Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Methotrexate; Middle Aged; Severity of Illness Index | 2018 |
Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2018 |
Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Severity of Illness Index | 2018 |
Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor alpha and interferon gamma in serum and synovial fluid\
in rheumatoid arthritis patients with symptom pattern of damp heat obstruction.
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Interferon-gamma; Male; Methotrexate; Middle Aged; Synovial Fluid; Tumor Necrosis Factor-alpha | 2016 |
Joint longitudinal model development: application to exposure-response modeling of ACR and DAS scores in rheumatoid arthritis patients treated with sirukumab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Endpoint Determination; Humans; Injections, Subcutaneous; Interleukin-6; Longitudinal Studies; Methotrexate | 2018 |
Predictive value of a multi-biomarker disease activity score for clinical remission and radiographic progression in patients with early rheumatoid arthritis: a post-hoc study of the OPERA trial.
Topics: Adalimumab; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2019 |
A Pilot Randomized Controlled Double-Blind Trial of High- Versus Low-Dose Weekly Folic Acid in People With Rheumatoid Arthritis Receiving Methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Acuity; Pilot Projects; Treatment Outcome; Vitamin B Complex | 2019 |
Dual inhibition of tumour necrosis factor and interleukin-17A with ABT-122: open-label long-term extension studies in rheumatoid arthritis or psoriatic arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulins; Interleukin-17; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Clinical, Ultrasound, and Predictability Outcomes Following Certolizumab Pegol Treatment (with Methotrexate) in Patients with Moderate-to-Severe Rheumatoid Arthritis: 52-Week Results from the CZP-SPEED Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2018 |
A randomized controlled trial comparing PF-06438179/GP1111 (an infliximab biosimilar) and infliximab reference product for treatment of moderate to severe active rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Therapeutic Equivalency | 2018 |
Tofacitinib, an oral Janus kinase inhibitor, in patients from Brazil with rheumatoid arthritis: Pooled efficacy and safety analyses.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Brazil; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2018 |
Predictors of disease activity and structural progression after treatment with adalimumab plus methotrexate or continued methotrexate monotherapy in patients with early rheumatoid arthritis and suboptimal response to methotrexate.
Topics: Adalimumab; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retreatment; Severity of Illness Index; Treatment Failure | 2018 |
Structural damage progression in patients with early rheumatoid arthritis treated with methotrexate, baricitinib, or baricitinib plus methotrexate based on clinical response in the phase 3 RA-BEGIN study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; C-Reactive Protein; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2018 |
Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate: the DINORA trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2018 |
Intravenous Infusion of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Rheumatoid Arthritis: A Phase Ia Clinical Trial.
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cytokines; Female; Fetal Blood; Health Status; Humans; Infusions, Intravenous; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2018 |
Clinical Responses and Synovial Vascularity in Obese Rheumatoid Arthritis Patients Treated with Adalimumab and Methotrexate.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Obesity; Synovial Membrane; Treatment Outcome | 2018 |
A pooled analysis of the safety of tofacitinib as monotherapy or in combination with background conventional synthetic disease-modifying antirheumatic drugs in a Phase 3 rheumatoid arthritis population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome; Young Adult | 2018 |
Mobile Phone Text Messages and Effect on Treatment Adherence in Patients Taking Methotrexate for Rheumatoid Arthritis: A Randomized Pilot Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Phone; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Prospective Studies; Text Messaging; Treatment Adherence and Compliance; Treatment Outcome | 2019 |
Maintenance of low disease activity and remission with etanercept-disease-modifying antirheumatic drug (DMARD) combination therapy compared with treatment with DMARDs alone in Latin American patients with active rheumatoid arthritis: Subset analysis of a
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Latin America; Male; Methotrexate; Middle Aged; Quality of Life; Remission Induction; Single-Blind Method; Treatment Outcome | 2018 |
Safety Profile of Baricitinib in Patients with Active Rheumatoid Arthritis with over 2 Years Median Time in Treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2019 |
Interaction between B-cell activation factor and methotrexate impacts immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Drug Interactions; Female; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged | 2019 |
Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Drug Therapy, Combination; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Methotrexate; Middle Aged; Remission Induction; Systems Biology; Treatment Outcome | 2018 |
On-drug and drug-free remission by baseline symptom duration: abatacept with methotrexate in patients with early rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Recovery of Function; Remission Induction; Time Factors; Treatment Outcome | 2018 |
Subcutaneous tocilizumab alone or with a csDMARD in rheumatoid arthritis patients: subanalysis of Italian data from a multicenter phase IIIb/IV trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Injections, Subcutaneous; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 2019 |
Efficacy of denosumab with regard to bone destruction in prognostic subgroups of Japanese rheumatoid arthritis patients from the phase II DRIVE study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Density Conservation Agents; Bone Resorption; Denosumab; Disease Progression; Double-Blind Method; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Prognosis; Rheumatoid Factor; Treatment Outcome | 2019 |
A clinical study on the combined therapy of methotrexate and immuno adsorption in the treatment of rheumatoid arthritis disease.
Topics: Adsorption; Adult; Aged; Antigens, Nuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Young Adult | 2018 |
[Efficacy of Hebi Formula Combined Methotrexate on Early Rheumatoid Arthritis Patients with Dis- harmony of Gan and Pi Syndrome and Its Effects on Serum MMP-3 and RANK/RANKL/OPG Expressions].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drugs, Chinese Herbal; Humans; Matrix Metalloproteinase 3; Methotrexate; Osteoprotegerin; RANK Ligand; Rheumatoid Factor; Syndrome | 2016 |
MRI and Dose Selection in a Phase II Trial of Baricitinib with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Sulfonamides; Synovitis; Treatment Outcome | 2019 |
In rheumatoid arthritis, changes in autoantibody levels reflect intensity of immunosuppression, not subsequent treatment response.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Female; Humans; Immune Tolerance; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prednisone; Severity of Illness Index | 2019 |
Tofacitinib in Combination With Methotrexate in Patients With Rheumatoid Arthritis: Clinical Efficacy, Radiographic, and Safety Outcomes From a Twenty-Four-Month, Phase III Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2019 |
Serum Biomarkers for Prediction of Response to Methotrexate Monotherapy in Early Rheumatoid Arthritis: Results from the SWEFOT Trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Female; Humans; Leptin; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor, Type I; Remission Induction; Treatment Outcome; Vascular Cell Adhesion Molecule-1 | 2019 |
Long-Term Efficacy and Safety of Biosimilar CT-P10 Versus Innovator Rituximab in Rheumatoid Arthritis: 48-Week Results from a Randomized Phase III Trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Blood Sedimentation; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Rituximab; Young Adult | 2019 |
The efficacy of the traditional Chinese medicine Jia Wei Niu Bang Zi granule combined with methotrexate in treating active rheumatoid arthritis: A multicenter, randomized, double-blinded controlled clinical trial.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult | 2019 |
Toreforant, an orally active histamine H
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Benzimidazoles; Double-Blind Method; Female; Histamine Antagonists; Humans; Interleukin-17; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Receptors, Histamine H4; Synovial Membrane; Treatment Outcome; Young Adult | 2019 |
Normal mortality of the COBRA early rheumatoid arthritis trial cohort after 23 years of follow-up.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2019 |
Radiographic and clinical outcomes following etanercept monotherapy in Japanese methotrexate-naïve patients with active rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Treatment Outcome | 2020 |
Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Leflunomide; Male; Methotrexate; Middle Aged; Morphinans; Treatment Outcome | 2019 |
Efficacy and safety of add-on tacrolimus versus leflunomide in rheumatoid arthritis patients with inadequate response to methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Middle Aged; Republic of Korea; Severity of Illness Index; Tacrolimus; Time Factors; Treatment Outcome; Young Adult | 2019 |
Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Nasopharyngitis; Neutropenia; Severity of Illness Index; Treatment Outcome | 2019 |
Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocyte Subsets; Biomarkers; Bone Remodeling; CD40 Ligand; Double-Blind Method; Female; Humans; Inflammation Mediators; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Severity of Illness Index; Young Adult | 2019 |
Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I-III Clinical Trials.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Case-Control Studies; Delayed-Action Preparations; Female; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged | 2019 |
Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an i
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Diacerein for the treatment of rheumatoid arthritis in patients with inadequate response to methotrexate: a pilot randomized, double-blind, placebo-controlled add-on trial.
Topics: Adult; Anthraquinones; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Retreatment; Treatment Outcome | 2019 |
Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2019 |
Magnetic Resonance Imaging (MRI) Results Following Discontinuation of Methotrexate in Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: The COMP-ACT MRI Substudy.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Osteitis; Pilot Projects; Synovitis; Treatment Outcome | 2020 |
Live Zoster Vaccine in Patients With Rheumatoid Arthritis Treated With Tofacitinib With or Without Methotrexate, or Adalimumab With Methotrexate: A Post Hoc Analysis of Data From a Phase IIIb/IV Randomized Study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Herpes Zoster; Herpes Zoster Vaccine; Humans; Incidence; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles | 2020 |
Efficacy and Safety of Long-Term Baricitinib With and Without Methotrexate for the Treatment of Rheumatoid Arthritis: Experience With Baricitinib Monotherapy Continuation or After Switching From Methotrexate Monotherapy or Baricitinib Plus Methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2020 |
Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; DNA; DNA Methylation; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Leukocytes; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Single-Blind Method; Tandem Mass Spectrometry; Treatment Outcome | 2019 |
Impact of flare on radiographic progression after etanercept continuation, tapering or withdrawal in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; Withholding Treatment | 2020 |
Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Creatine Kinase; Double-Blind Method; Drug Therapy, Combination; Female; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Infections; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Severity of Illness Index; Venous Thromboembolism | 2019 |
Improvement in cardiovascular biomarkers sustained at 4 years following an initial treat-to-target strategy in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Methylprednisolone; Middle Aged | 2019 |
Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan.
Topics: Adamantane; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Substitution; Female; Herpes Zoster; Humans; Immunosuppressive Agents; Infections; Janus Kinase Inhibitors; Japan; Male; Methotrexate; Middle Aged; Niacinamide; Severity of Illness Index; Treatment Outcome | 2019 |
Safety and effectiveness of upadacitinib or adalimumab plus methotrexate in patients with rheumatoid arthritis over 48 weeks with switch to alternate therapy in patients with insufficient response.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Heterocyclic Compounds, 3-Ring; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2019 |
Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cytoprotection; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Liver; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Paeonia; Plant Roots; Young Adult | 2013 |
Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind,
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Quality of Life; Remission Induction; Severity of Illness Index; Treatment Outcome; Triamcinolone | 2014 |
Exposure-response relationship of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Models, Biological; Receptors, Interleukin-6; Serum Amyloid A Protein; Severity of Illness Index; Treatment Outcome | 2013 |
Evaluation of serum biomarkers associated with radiographic progression in methotrexate-naive rheumatoid arthritis patients treated with methotrexate or golimumab.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD40 Ligand; Disease Progression; Drug Therapy, Combination; Epidermal Growth Factor; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index | 2013 |
Changes in lipoproteins associated with methotrexate or combination therapy in early rheumatoid arthritis: results from the treatment of early rheumatoid arthritis trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome | 2013 |
[Short-term clinical observation on compound Xiatianwu combined with methotrexate in treating rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2012 |
A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Computer Simulation; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Models, Biological; Polyglutamic Acid | 2013 |
Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis: results from the SWEFOT trial.
Topics: Absorptiometry, Photon; Analysis of Variance; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Chi-Square Distribution; Disease Progression; Drug Therapy, Combination; Early Diagnosis; Female; Hand Bones; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Odds Ratio; Predictive Value of Tests; Risk Assessment; Risk Factors; Sulfasalazine; Sweden; Time Factors; Treatment Outcome | 2013 |
Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932).
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Female; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Rituximab; Wrist Joint | 2013 |
Early local swelling and tenderness are associated with large-joint damage after 8 years of treatment to target in patients with recent-onset rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Edema; Female; Health Status; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Recovery of Function; Severity of Illness Index; Surveys and Questionnaires | 2013 |
Clinical response within 12 weeks as a predictor of future low disease activity in patients with early RA: results from the TEAR Trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Prognosis; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sulfasalazine; Symptom Assessment; Time Factors; Treatment Outcome | 2013 |
A phase 2 dose-ranging study of subcutaneous tabalumab for the treatment of patients with active rheumatoid arthritis and an inadequate response to methotrexate.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Health Status; Humans; Injections, Subcutaneous; Joints; Male; Methotrexate; Middle Aged; Pilot Projects; Severity of Illness Index; Treatment Outcome; Young Adult | 2013 |
A non-inferiority trial of an attenuated combination strategy ('COBRA-light') compared to the original COBRA strategy: clinical results after 26 weeks.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Sulfasalazine; Treatment Outcome | 2014 |
Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial.
Topics: Adult; Aged; Alendronate; Antirheumatic Agents; Arthritis, Rheumatoid; Betamethasone; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Bone Resorption; Cyclosporine; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Young Adult | 2014 |
Induction of response with etanercept-methotrexate therapy in patients with moderately active rheumatoid arthritis in Central and Eastern Europe in the PRESERVE study.
Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Administration Schedule; Etanercept; Europe, Eastern; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Sleep; Surveys and Questionnaires; Treatment Outcome | 2013 |
Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: results through 2 years of the GO-FORWARD study extension.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2013 |
Validation of the methotrexate-first strategy in patients with early, poor-prognosis rheumatoid arthritis: results from a two-year randomized, double-blind trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Hydroxychloroquine; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Prognosis; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome | 2013 |
A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2013 |
A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study.
Topics: Adalimumab; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisone; Radiography; Remission Induction; Single-Blind Method; Sulfasalazine; Treatment Outcome | 2014 |
Subcutaneously administered ofatumumab in rheumatoid arthritis: a phase I/II study of safety, tolerability, pharmacokinetics, and pharmacodynamics.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hypodermoclysis; Male; Methotrexate; Middle Aged; Single-Blind Method; Treatment Outcome | 2013 |
Sustained clinical remission and rate of relapse after tocilizumab withdrawal in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Recurrence; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome | 2013 |
Therapies for active rheumatoid arthritis after methotrexate failure.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sulfasalazine; Treatment Failure | 2013 |
Biological vs. conventional combination treatment and work loss in early rheumatoid arthritis: a randomized trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Pensions; Sick Leave; Sulfasalazine; Sweden; Treatment Outcome; Young Adult | 2013 |
Clinical, functional, and radiographic benefits of longterm adalimumab plus methotrexate: final 10-year data in longstanding rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome | 2013 |
Golimumab, a human anti–tumor necrosis factor monoclonal antibody, injected subcutaneously every 4 weeks in patients with active rheumatoid arthritis who had never taken methotrexate: 1-year and 2-year clinical, radiologic, and physical function findings
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Motor Activity; Radiography; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Clarithromycin in rheumatoid arthritis: the addition to methotrexate and low-dose methylprednisolone induces a significant additive value--a 24-month single-blind pilot study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Clarithromycin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Pilot Projects; Single-Blind Method; Treatment Outcome | 2013 |
The relationship between disease activity and depressive symptoms severity and optimism--results from the IMPROVED study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude; Depression; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prednisone; Regression Analysis; Remission Induction; Severity of Illness Index; Surveys and Questionnaires | 2013 |
Insights into the efficacy of golimumab plus methotrexate in patients with active rheumatoid arthritis who discontinued prior anti-tumour necrosis factor therapy: post-hoc analyses from the GO-AFTER study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Substitution; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Early MRI measures independently predict 1-year and 2-year radiographic progression in rheumatoid arthritis: secondary analysis from a large clinical trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Diseases; Disease Progression; Drug Therapy, Combination; Early Diagnosis; Edema; Female; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Radiography; Synovitis; Wrist Joint | 2014 |
[Treating rheumatoid arthritis patients of Shen deficiency and cold invading syndrome by bushen quhan zhiwang decoction combined methotrexate: an evaluation of clinical efficacy and safety].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2013 |
Long-term safety and efficacy of certolizumab pegol in combination with methotrexate in the treatment of rheumatoid arthritis: 5-year results from the RAPID 1 trial and open-label extension.
Topics: Adult; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Certolizumab Pegol; Cohort Studies; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Longitudinal Studies; Male; Methotrexate; Middle Aged; Pharyngitis; Polyethylene Glycols; Respiratory Tract Infections; Treatment Outcome; Urinary Tract Infections | 2014 |
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis.
Topics: Administration, Intravenous; Adolescent; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antirheumatic Agents; Arthritis, Rheumatoid; Broadly Neutralizing Antibodies; Cytokine TWEAK; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Inflammation; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; TWEAK Receptor; Young Adult | 2013 |
Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial.
Topics: Abatacept; Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2014 |
The Canadian methotrexate and etanercept outcome study: a randomised trial of discontinuing versus continuing methotrexate after 6 months of etanercept and methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Time Factors; Treatment Outcome; Withholding Treatment | 2014 |
Upregulated baseline plasma CCL19 and CCR7 cell-surface expression on monocytes in early rheumatoid arthritis normalized during treatment and CCL19 correlated with radiographic progression.
Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; CD4-Positive T-Lymphocytes; Chemokine CCL19; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Monocytes; Peptides, Cyclic; Radiography; Receptors, CCR7; Severity of Illness Index; Treatment Outcome; Up-Regulation | 2014 |
Radiographic benefit and maintenance of clinical benefit with intravenous golimumab therapy in patients with active rheumatoid arthritis despite methotrexate therapy: results up to 1 year of the phase 3, randomised, multicentre, double blind, placebo cont
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Foot Joints; Hand Joints; Humans; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Young Adult | 2014 |
M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Ficolins; Humans; Lectins; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Remission Induction; Severity of Illness Index; Treatment Outcome | 2013 |
Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2013 |
Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Docosahexaenoic Acids; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Eicosapentaenoic Acid; Female; Fish Oils; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome | 2015 |
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2013 |
Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome | 2014 |
Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis.
Topics: Aged; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Betamethasone; Biomarkers; Case-Control Studies; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interleukins; Longitudinal Studies; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Programmed Cell Death 1 Receptor; Radiography; Rheumatoid Factor; Severity of Illness Index | 2014 |
Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Observer Variation; Prospective Studies; Receptors, Tumor Necrosis Factor; Sensitivity and Specificity; Synovitis; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler | 2013 |
Longterm effect of delaying combination therapy with tumor necrosis factor inhibitor in patients with aggressive early rheumatoid arthritis: 10-year efficacy and safety of adalimumab from the randomized controlled PREMIER trial with open-label extension.
Topics: Adalimumab; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2014 |
Rheumatoid arthritis: Optimizing treatment strategies in early RA.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Early Diagnosis; Humans; Methotrexate; Treatment Outcome | 2013 |
Addition of another disease-modifying anti-rheumatic drug to methotrexate reduces the flare rate within 2 years after infliximab discontinuation in patients with rheumatoid arthritis: an open, randomized, controlled trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Disease Progression; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2014 |
Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: an open-label extension of a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retreatment; Sulfonamides; Treatment Outcome | 2014 |
Four-month metacarpal bone mineral density loss predicts radiological joint damage progression after 1 year in patients with early rheumatoid arthritis: exploratory analyses from the IMPROVED study.
Topics: Absorptiometry, Photon; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Disease Progression; Female; Humans; Hydroxychloroquine; Male; Metacarpal Bones; Methotrexate; Middle Aged; Prednisone; Sulfasalazine | 2015 |
A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis.
Topics: Abdominal Pain; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Cough; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Female; Headache; Humans; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Receptors, Interleukin-17; Treatment Outcome | 2013 |
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoconjugates; Immunoglobulin G; Logistic Models; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Rituximab; Serotyping; Streptococcus pneumoniae; Treatment Outcome; Young Adult | 2013 |
Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Affinity; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Oncostatin M; Single-Blind Method; Time Factors; Treatment Outcome | 2013 |
Gene-body mass index interactions are associated with methotrexate toxicity in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Gene-Environment Interaction; Humans; Methotrexate; Polymorphism, Single Nucleotide | 2014 |
Clinical, functional, and radiographic implications of time to treatment response in patients with early rheumatoid arthritis: a posthoc analysis of the PREMIER study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Foot; Hand; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome; Wrist | 2014 |
Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blotting, Western; Bone Resorption; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Osteoclasts; Osteoprotegerin; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane | 2013 |
Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Severity of Illness Index; Treatment Outcome | 2014 |
Is it safe to withdraw etanercept in established rheumatoid arthritis after low disease activity achievement?
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2014 |
Efficacy and safety of certolizumab pegol plus methotrexate in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: the J-RAPID randomized, placebo-controlled trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Certolizumab Pegol; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Japan; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Quality of Life; Retreatment; Treatment Outcome | 2014 |
A clinical trial and extension study of infliximab in Korean patients with active rheumatoid arthritis despite methotrexate treatment.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Placebo Effect; Republic of Korea; Severity of Illness Index; Time Factors; Treatment Outcome | 2013 |
Combination of Mangifera indica L. extract supplementation plus methotrexate in rheumatoid arthritis patients: a pilot study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Mangifera; Methotrexate; Middle Aged; Pilot Projects; Plant Extracts; Treatment Outcome | 2014 |
Golimumab 3-year safety update: an analysis of pooled data from the long-term extensions of randomised, double-blind, placebo-controlled trials conducted in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing; Treatment Outcome | 2015 |
Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Inflammation; Infliximab; Male; Methotrexate; Middle Aged; Models, Biological; Prednisone | 2014 |
Open-label observation of addition of etanercept versus a conventional disease-modifying antirheumatic drug in subjects with active rheumatoid arthritis despite methotrexate therapy in the Latin American region.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Latin America; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2014 |
The role of bromocriptine in the treatment of patients with active rheumatoid arthritis.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bromocriptine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Iran; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2013 |
A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the
Topics: Adalimumab; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intra-Articular; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Osteitis; Patient Care Planning; Severity of Illness Index; Synovitis; Tenosynovitis; Treatment Outcome; Triamcinolone; Wrist Joint; Young Adult | 2015 |
Continued benefit of tocilizumab plus disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis and inadequate clinical responses by week 8 of treatment.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2014 |
Safety of etanercept and methotrexate in patients with rheumatoid arthritis and hepatitis C virus infection: a multicenter randomized clinical trial.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Drug Therapy, Combination; Etanercept; Female; Hepacivirus; Hepatitis C; Humans; Immunoglobulin G; Liver Function Tests; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Viral Load; Virus Replication | 2014 |
Certolizumab pegol in rheumatoid arthritis patients with low to moderate activity: the CERTAIN double-blind, randomised, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2015 |
ACPA-positive and ACPA-negative rheumatoid arthritis differ in their requirements for combination DMARDs and corticosteroids: secondary analysis of a randomized controlled trial.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Cyclosporine; Disease Progression; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisolone; Quality of Life | 2014 |
Recovery of clinical but not radiographic outcomes by the delayed addition of adalimumab to methotrexate-treated Japanese patients with early rheumatoid arthritis: 52-week results of the HOPEFUL-1 trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Disease Progression; Drug Therapy, Combination; Female; Humans; Japan; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
The effect of tocilizumab on bone mineral density in patients with methotrexate-resistant active rheumatoid arthritis.
Topics: Absorptiometry, Photon; Adult; Aged; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Bone Density; Bone Diseases, Metabolic; Drug Resistance; Female; Femur Neck; Humans; Interleukin-6; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2014 |
An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete B cell depletion: a randomised controlled trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lymphocyte Count; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome | 2015 |
Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA).
Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunity, Humoral; Male; Methotrexate; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Tetanus; Tetanus Toxoid; Young Adult | 2015 |
Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study.
Topics: Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2014 |
Health-related quality of life and functional ability in patients with early arthritis during remission steered treatment: results of the IMPROVED study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Satisfaction; Prednisone; Quality of Life; Range of Motion, Articular; Recovery of Function; Remission Induction; Severity of Illness Index; Single-Blind Method; Sulfasalazine; Time Factors; Treatment Outcome | 2013 |
The effects of tocilizumab on osteitis, synovitis and erosion progression in rheumatoid arthritis: results from the ACT-RAY MRI substudy.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Joints; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Osteitis; Synovitis; Treatment Outcome | 2014 |
MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Methotrexate; Middle Aged; Nasopharyngitis; Pleurisy; Treatment Outcome | 2015 |
Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2015 |
Subcutaneous abatacept for the treatment of rheumatoid arthritis: longterm data from the ACQUIRE trial.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoconjugates; Injections, Intravenous; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Pain Measurement; Patient Safety; Risk Assessment; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: 52-week results from an open-label extension of the J-RAPID study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Certolizumab Pegol; Disease Progression; Double-Blind Method; Drug Administration Schedule; Female; Humans; Immunoglobulin Fab Fragments; Japan; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Quality of Life; Retreatment; Treatment Outcome | 2014 |
Secukinumab treatment in rheumatoid arthritis is associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Health Status; Health Surveys; Humans; Male; Methotrexate; Middle Aged; Placebos; Quality of Life; Recovery of Function; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2014 |
A randomised controlled trial of etanercept and methotrexate to induce remission in early inflammatory arthritis: the EMPIRE trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Etanercept; Female; Humans; Immunoglobulin G; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Rheumatoid Factor; Synovitis; Treatment Outcome; Young Adult | 2014 |
Effects of Janus kinase inhibitor tofacitinib on circulating serum amyloid A and interleukin-6 during treatment for rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Down-Regulation; Female; Humans; Interleukin-6; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Placebos; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Serum Amyloid A Protein | 2014 |
A randomized, double-blind, and placebo-controlled multicenter clinical trial of a novel cytotoxic T-lymphocyte antigen-4 fusion protein, Leining, in Chinese active rheumatoid arthritis patients with an inadequate response to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Blood Sedimentation; China; Disability Evaluation; Double-Blind Method; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Recombinant Fusion Proteins; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Assessment of the treat-to-target strategy in patients with refractory rheumatoid arthritis. A prospective study on efficacy and safety in a Saudi population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chronic Disease; Drug Resistance; Female; Humans; Male; Methotrexate; Middle Aged; Molecular Targeted Therapy; Prospective Studies; Saudi Arabia; Treatment Outcome; Young Adult | 2014 |
Effect of methotrexate use and erythrocyte methotrexate polyglutamate on glycosylated hemoglobin in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Erythrocytes; Female; Glycated Hemoglobin; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Prospective Studies | 2014 |
Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2014 |
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Smoking; Sulfasalazine; Treatment Outcome | 2015 |
Efficacy, safety, pharmacokinetics and immunogenicity of abatacept administered subcutaneously or intravenously in Japanese patients with rheumatoid arthritis and inadequate response to methotrexate: a Phase II/III, randomized study.
Topics: Abatacept; Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Humans; Immunoconjugates; Injections, Intravenous; Injections, Subcutaneous; Japan; Male; Methotrexate; Middle Aged; Retreatment; Treatment Outcome | 2014 |
Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2015 |
Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≥15 mg may be overcome with subcutaneous administration.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Self Administration | 2014 |
Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Plant Extracts; Single-Blind Method; Treatment Outcome; Tripterygium | 2015 |
Cost-effectiveness of infliximab versus conventional combination treatment in methotrexate-refractory early rheumatoid arthritis: 2-year results of the register-enriched randomised controlled SWEFOT trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Health Care Costs; Health Services; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Sick Leave; Sulfasalazine; Treatment Failure; Treatment Outcome | 2015 |
[Treatment of rheumatoid arthritis by Yangxue Tongluo Recipe combined with immunosuppressive agents: a clinical observation].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Phytotherapy; Treatment Outcome | 2014 |
Traditional Chinese medicine versus western medicine as used in China in the management of rheumatoid arthritis: a randomized, single-blind, 24-week study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Drug Administration Schedule; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Methotrexate; Remission Induction; Single-Blind Method; Sulfasalazine; Time Factors; Treatment Outcome; Western World | 2014 |
Treatment of rheumatoid arthritis with biologic DMARDS (Rituximab and Etanercept).
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Rituximab | 2014 |
Longterm safety, efficacy, and inhibition of structural damage progression over 5 years of treatment with abatacept in patients with rheumatoid arthritis in the abatacept in inadequate responders to methotrexate trial.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Foot Joints; Hand Joints; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Radiography; Retreatment; Treatment Outcome | 2014 |
Randomised comparison of initial triple DMARD therapy with methotrexate monotherapy in combination with low-dose glucocorticoid bridging therapy; 1-year data of the tREACH trial.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Injections, Intramuscular; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Single-Blind Method; Sulfasalazine; Treatment Outcome | 2014 |
Good response to infliximab in rheumatoid arthritis following failure of interleukin-1 receptor antagonist.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; China; Double-Blind Method; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Female; Health Status Indicators; Humans; Infliximab; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Failure | 2016 |
Pretreatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial.
Topics: Adipokines; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Chitinase-3-Like Protein 1; Disease Progression; Drug Therapy, Combination; Epidermal Growth Factor; Female; Foot Joints; Hand Joints; Humans; Hydroxychloroquine; Infliximab; Interleukin-6; Lectins; Leptin; Logistic Models; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Multivariate Analysis; Prognosis; Radiography; Receptors, Tumor Necrosis Factor, Type I; Resistin; Serum Amyloid A Protein; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2015 |
Intensive combination treatment regimens, including prednisolone, are effective in treating patients with early rheumatoid arthritis regardless of additional etanercept: 1-year results of the COBRA-light open-label, randomised, non-inferiority trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Medical Intervention; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Prednisolone; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome | 2015 |
Short-term efficacy of etanercept plus methotrexate vs combinations of disease-modifying anti-rheumatic drugs with methotrexate in established rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Herpes Zoster; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles | 2014 |
Teaching methotrexate self-injection with a web-based video maintains patient care while reducing healthcare resources: a pilot study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Delivery of Health Care; Female; Health Knowledge, Attitudes, Practice; Humans; Injections; Male; Methotrexate; Middle Aged; Patient Care; Patient Education as Topic; Patient Satisfaction; Pilot Projects; Self Administration | 2015 |
Prediction of methotrexate clinical response in Portuguese rheumatoid arthritis patients: implication of MTHFR rs1801133 and ATIC rs4673993 polymorphisms.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Genotype; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Portugal; Risk Factors | 2014 |
Randomized controlled trial comparing 2 different starting doses of methotrexate in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2014 |
Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: the HIKARI randomized, placebo-controlled trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disease Progression; Double-Blind Method; Female; Humans; Immunoglobulin Fab Fragments; Japan; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Treatment Outcome; Young Adult | 2014 |
Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Case-Control Studies; Cell Cycle; Cell Survival; Cells, Cultured; Female; Humans; In Vitro Techniques; Male; Methotrexate; Middle Aged; Osteoarthritis; Spondylitis, Ankylosing; Synovial Membrane; Time Factors; Young Adult | 2014 |
Efficacy of golimumab plus methotrexate in methotrexate-naïve patients with severe active rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2014 |
Nearly pain-free self-administration of subcutaneous methotrexate with an autoinjector: results of a phase 2 clinical trial in patients with rheumatoid arthritis who have functional limitations.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedule; Equipment Design; Female; Humans; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Pain Measurement; Self Administration; Severity of Illness Index; Syringes; Treatment Outcome | 2014 |
Effect of etanercept, infliximab and methotrexate in the treatment of arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2015 |
Infliximab efficacy in rheumatoid arthritis after an inadequate response to etanercept or adalimumab: results of a target-driven active switch study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Substitution; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Single-Blind Method; Time Factors; Treatment Outcome | 2014 |
Analysis of integrated radiographic data from two long-term, open-label extension studies of adalimumab for the treatment of rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2015 |
The impact of DMARD and anti-TNF therapy on functional characterization of short-term T-cell activation in patients with rheumatoid arthritis--a follow-up study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Nitric Oxide; Reactive Oxygen Species; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
When to adjust therapy in patients with rheumatoid arthritis after initiation of etanercept plus methotrexate or methotrexate alone: findings from a randomized study (COMET).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Retreatment; Severity of Illness Index; Treatment Outcome | 2014 |
Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese.
Topics: Acid Phosphatase; Adolescent; Adult; Antibodies, Monoclonal; Arthritis, Rheumatoid; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infliximab; Isoenzymes; Male; Methotrexate; Middle Aged; Osteoclasts; Pilot Projects; Tartrate-Resistant Acid Phosphatase; Young Adult | 2014 |
Comprehensive disease control (CDC): what does achieving CDC mean for patients with rheumatoid arthritis?
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Severity of Illness Index; Treatment Outcome | 2015 |
Clinical and radiographic outcomes at 2 years and the effect of tocilizumab discontinuation following sustained remission in the second and third year of the ACT-RAY study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Foot Joints; Hand Joints; Humans; Induction Chemotherapy; Longitudinal Studies; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2015 |
Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: patient-reported outcomes from a phase III trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Self Report; Treatment Outcome | 2015 |
Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Models, Biological; Polyglutamic Acid; Treatment Outcome | 2014 |
Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Diarrhea; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Syk Kinase; Treatment Outcome; Young Adult | 2014 |
A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist.
Topics: Adult; Aminopyridines; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Maximum Tolerated Dose; Methotrexate; Middle Aged; Morpholines; Oxazines; Patient Safety; Prognosis; Pyridines; Pyrimidines; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Initial high-dose prednisolone combination therapy using COBRA and COBRA-light in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Methotrexate; Netherlands; Prednisolone; Sulfasalazine; Surveys and Questionnaires | 2015 |
CXCL13 predicts disease activity in early rheumatoid arthritis and could be an indicator of the therapeutic 'window of opportunity'.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokine CXCL13; Drug Therapy, Combination; Early Diagnosis; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Drug Therapy, Combination; Feasibility Studies; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission Induction; Risk Factors; Sulfasalazine; Time Factors; Treatment Outcome | 2014 |
[Evaluation of methotrexate effect on the acute-phase response in rheumatoid arthritis after 12-week treatment].
Topics: Acute-Phase Reaction; Adult; Aged; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Young Adult | 2014 |
Two dosing regimens of certolizumab pegol in patients with active rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Treatment Outcome | 2015 |
Randomised controlled trial of tumour necrosis factor inhibitors against combination intensive therapy with conventional disease-modifying antirheumatic drugs in established rheumatoid arthritis: the TACIT trial and associated systematic reviews.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Drug Therapy, Combination; England; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Severity of Illness Index; Social Work; Socioeconomic Factors; Tumor Necrosis Factor-alpha | 2014 |
Methotrexate in combination with other DMARDs is not superior to methotrexate alone for remission induction with moderate-to-high-dose glucocorticoid bridging in early rheumatoid arthritis after 16 weeks of treatment: the CareRA trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Medical Intervention; Female; Glucocorticoids; Humans; Induction Chemotherapy; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Risk Assessment; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2015 |
Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2015 |
Sustained remission with etanercept tapering in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infections; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Withholding Treatment | 2014 |
Coronary Artery Disease Evaluation in Rheumatoid Arthritis (CADERA): study protocol for a randomized controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Contrast Media; Coronary Artery Disease; Drug Therapy, Combination; England; Etanercept; Humans; Immunoglobulin G; Magnetic Resonance Imaging, Cine; Methotrexate; Predictive Value of Tests; Prevalence; Prospective Studies; Receptors, Tumor Necrosis Factor; Research Design; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Lipid profile of rheumatoid arthritis patients treated with anti-tumor necrosis factor-alpha drugs changes according to disease activity and predicts clinical response.
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Certolizumab Pegol; Cholesterol; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Lipid Metabolism; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha | 2014 |
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinase 1; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; RNA, Messenger; Signal Transduction; STAT Transcription Factors; Synovial Membrane; Treatment Outcome | 2015 |
Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Sulfonamides | 2015 |
Can we prevent rapid radiological progression in patients with early rheumatoid arthritis?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Foot Joints; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Models, Theoretical; Prednisone; Radiography; Risk Factors; Treatment Outcome | 2015 |
A phase IB clinical trial with Dekavil (F8-IL10), an immunoregulatory 'armed antibody' for the treatment of rheumatoid arthritis, used in combination wiIh methotrexate.
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Monitoring; Drug Therapy, Combination; Fibronectins; Humans; Immunologic Factors; Injections, Subcutaneous; Interleukin-10; Maximum Tolerated Dose; Methotrexate; Pilot Projects | 2014 |
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial.
Topics: Antibody Specificity; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Disease Progression; Drug Therapy, Combination; Female; Fibrinogen; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Phosphopyruvate Hydratase; Radiography; Sulfasalazine; Sweden; Vimentin | 2016 |
The effect of tocilizumab on bone mineral density, serum levels of Dickkopf-1 and bone remodeling markers in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biological Products; Biomarkers; Bone Density; Bone Remodeling; Collagen Type I; Double-Blind Method; Female; Glucocorticoids; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-6; Male; Methotrexate; Middle Aged | 2015 |
The number of circulating monocytes as biomarkers of the clinical response to methotrexate in untreated patients with rheumatoid arthritis.
Topics: Antigens, CD; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Cell Count; Cell Movement; CX3C Chemokine Receptor 1; Demography; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes; Receptors, Chemokine; ROC Curve; Treatment Outcome | 2015 |
Maintenance of Clinical and Radiographic Benefit With Intravenous Golimumab Therapy in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy: Week-112 Efficacy and Safety Results of the Open-Label Long-Term Extension of a Phase III, Doubl
Topics: Administration, Intravenous; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cross-Over Studies; Disability Evaluation; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Inflammation Mediators; Methotrexate; Quality of Life; Radiography; Recovery of Function; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2015 |
Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Prospective Studies; Recurrence; Withholding Treatment | 2016 |
Predictors for low disease activity and remission in rheumatoid arthritis patients treated with biological DMARDs.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Middle Aged; Prednisolone; Prognosis; Remission Induction; Socioeconomic Factors; Thailand; Time Factors; Treatment Outcome | 2014 |
Alternative Ways to Quantify Sustained Remission: Applying the Continuity Rewarded Score and Patient Vector Graph.
Topics: Adult; Aged; Arthritis, Rheumatoid; Data Display; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Prednisone; Prognosis; Remission Induction; Risk Assessment; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Interleukin-6 Receptor alpha Subunit; Male; Methotrexate; Middle Aged; Neutropenia; Treatment Outcome; Young Adult | 2015 |
Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Japan; Male; Methotrexate; Middle Aged; Treatment Outcome | 2015 |
Tumour necrosis factor inhibitors versus combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis: TACIT non-inferiority randomised controlled trial.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Piperidines; Pneumococcal Infections; Pneumococcal Vaccines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Young Adult | 2016 |
Full dose, reduced dose or discontinuation of etanercept in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Recurrence; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2016 |
Efficacy and safety of tabalumab, an anti-B-cell-activating factor monoclonal antibody, in patients with rheumatoid arthritis who had an inadequate response to methotrexate therapy: results from a phase III multicentre, randomised, double-blind study.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; B-Cell Activating Factor; Double-Blind Method; Early Termination of Clinical Trials; Humans; Intention to Treat Analysis; Methotrexate; Treatment Failure | 2015 |
A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Multivariate Analysis; Pain Measurement; Prospective Studies; Retreatment; Risk Assessment; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2015 |
Patients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
[The quality of life in patients with rheumatoid arthritis treated with rituximab].
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Quality of Life; Rituximab; Treatment Outcome | 2014 |
Predicted vs. observed radiographic progression in early rheumatoid arthritis (POPeRA): results from a randomized trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Sulfasalazine; Sweden; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Existing joint erosions increase the risk of joint space narrowing independently of clinical synovitis in patients with early rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Synovitis | 2015 |
Abatacept improves whole-body insulin sensitivity in rheumatoid arthritis: an observational study.
Topics: Abatacept; Adiposity; Arthritis, Rheumatoid; Blood Glucose; Blood Pressure; Body Mass Index; Drug Therapy, Combination; Female; Glucose Tolerance Test; Humans; Immunoconjugates; Insulin; Insulin Resistance; Male; Methotrexate; Middle Aged | 2015 |
Interpreting the multi-biomarker disease activity score in the context of tocilizumab treatment for patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Proteins; Disability Evaluation; Female; Humans; Inflammation Mediators; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Treatment Outcome | 2016 |
Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus.
Topics: Aged; Antibodies, Bacterial; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Tacrolimus | 2015 |
Evaluation of the Disease Activity Score in Twenty-Eight Joints-Based Flare Definitions in Rheumatoid Arthritis: Data From a Three-Year Clinical Trial.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asia; Biological Products; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Drug Therapy, Combination; Europe; Humans; Joints; Methotrexate; Predictive Value of Tests; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; United States | 2015 |
Itolizumab in combination with methotrexate modulates active rheumatoid arthritis: safety and efficacy from a phase 2, randomized, open-label, parallel-group, dose-ranging study.
Topics: Administration, Oral; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; India; Male; Methotrexate; Middle Aged; Patient Safety; Reproducibility of Results; Rheumatology; Surveys and Questionnaires; Treatment Outcome | 2016 |
Modelling the cost-effectiveness of combination therapy for early, rapidly progressing rheumatoid arthritis by simulating the reversible and irreversible effects of the disease.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cost-Benefit Analysis; Disease Progression; Drug Therapy, Combination; Female; Health Care Costs; Humans; Joints; Logistic Models; Male; Methotrexate; Middle Aged; Models, Biological; Pain; Quality-Adjusted Life Years; Severity of Illness Index | 2015 |
Comparison of two different folic acid doses with methotrexate--a randomized controlled trial (FOLVARI Study).
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 2015 |
Attainment and characteristics of clinical remission according to the new ACR-EULAR criteria in abatacept-treated patients with early rheumatoid arthritis: new analyses from the Abatacept study to Gauge Remission and joint damage progression in methotrexa
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2015 |
Interleukin-23 in early disease development in rheumatoid arthritis.
Topics: Adalimumab; Adult; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Cohort Studies; Disease Progression; Drug Therapy, Combination; Female; Humans; Interleukin-23; Male; Methotrexate; Middle Aged; Pain Measurement; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Validity of early MRI structural damage end points and potential impact on clinical trial design in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Endpoint Determination; Female; Foot Joints; Hand Joints; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiography; Reproducibility of Results; Research Design; Sample Size; Severity of Illness Index; Single-Blind Method; Treatment Outcome | 2016 |
The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, dose-ra
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Interleukin-6; International Cooperation; Male; Methotrexate; Middle Aged; Severity of Illness Index; Surveys and Questionnaires; Treatment Failure; Treatment Outcome | 2015 |
The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.
Topics: Adult; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prognosis; Radiography; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2016 |
Efficacy and safety evaluation of a combination of iguratimod and methotrexate therapy for active rheumatoid arthritis patients: a randomized controlled trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; China; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfonamides; Treatment Outcome | 2015 |
A phase III randomised, double-blind, parallel-group study comparing SB4 with etanercept reference product in patients with active rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Therapeutic Equivalency; Treatment Outcome | 2017 |
Improvement in patient-reported outcomes after rituximab in rheumatoid arthritis patients: An open-label assessment of 175 patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Patient Outcome Assessment; Rituximab; Treatment Outcome | 2015 |
Certolizumab Pegol Efficacy Across Methotrexate Regimens: A Pre-Specified Analysis of Two Phase III Trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Radiography; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Efficacy and safety results from a Phase 3, randomized, placebo-controlled trial of subcutaneous golimumab in Chinese patients with active rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; China; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Quality of Life; Remission Induction; Time Factors; Treatment Failure; Treatment Outcome | 2016 |
Assessment of Substantial Liver Fibrosis by Real-time Shear Wave Elastography in Methotrexate-Treated Patients With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Causality; Chemical and Drug Induced Liver Injury; Comorbidity; Computer Systems; Elasticity Imaging Techniques; Female; Humans; Incidence; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Reproducibility of Results; Republic of Korea; Risk Factors; Sensitivity and Specificity | 2015 |
Efficacy and safety of tofacitinib following inadequate response to conventional synthetic or biological disease-modifying antirheumatic drugs.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
A patient-initiated DMARD self-monitoring service for people with rheumatoid or psoriatic arthritis on methotrexate: a randomised controlled trial.
Topics: Ambulatory Care; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Monitoring, Ambulatory; Self Care; Severity of Illness Index; Treatment Outcome | 2016 |
Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Paeonia; Treatment Outcome; Young Adult | 2015 |
A randomised, double-blind, phase III study comparing SB2, an infliximab biosimilar, to the infliximab reference product Remicade in patients with moderate to severe rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index; Therapeutic Equivalency; Treatment Outcome | 2017 |
Impact of physicians' adherence to treat-to-target strategy on outcomes in early rheumatoid arthritis in the NEO-RACo trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Finland; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Multivariate Analysis; Practice Patterns, Physicians'; Prednisolone; Remission Induction; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Certolizumab pegol plus methotrexate 5-year results from the rheumatoid arthritis prevention of structural damage (RAPID) 2 randomized controlled trial and long-term extension in rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infections; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 2015 |
Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial.
Topics: Abatacept; Adalimumab; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prognosis; Single-Blind Method; Treatment Outcome; Young Adult | 2016 |
Two-year radiographic and clinical outcomes from the Canadian Methotrexate and Etanercept Outcome study in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Follow-Up Studies; Injections, Subcutaneous; Methotrexate; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome | 2016 |
Immunological evaluation of rheumatoid arthritis patients treated with itolizumab.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; B-Lymphocytes; Cytokines; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; T-Lymphocytes | 2016 |
Prevention of joint destruction in patients with high disease activity or high C-reactive protein levels: Post hoc analysis of the GO-FORTH study.
Topics: Administration, Oral; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2016 |
VX-509 (Decernotinib), an Oral Selective JAK-3 Inhibitor, in Combination With Methotrexate in Patients With Rheumatoid Arthritis.
Topics: Administration, Oral; Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Heterocyclic Compounds, 2-Ring; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Treatment Outcome; Valine; Young Adult | 2016 |
Clinical efficacy, radiographic progression, and safety through 156 weeks of therapy with subcutaneous golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis despite prior methotrexate therapy: final results of th
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Foot Joints; Hand Joints; Humans; Methotrexate; Radiography; Treatment Outcome | 2016 |
Efficacy and Safety of Subcutaneous Golimumab in Methotrexate-Naive Patients With Rheumatoid Arthritis: Five-Year Results of a Randomized Clinical Trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2016 |
Clinical and radiographic outcome of a treat-to-target strategy using methotrexate and intra-articular glucocorticoids with or without adalimumab induction: a 2-year investigator-initiated, double-blinded, randomised, controlled trial (OPERA).
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Treatment Outcome; Triamcinolone | 2016 |
Iguratimod in combination with methotrexate in active rheumatoid arthritis : Therapeutic effects.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; China; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Evidence-Based Medicine; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Patient Satisfaction; Prevalence; Risk Factors; Sulfonamides; Treatment Outcome | 2016 |
Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2016 |
Effects of Methotrexate on Carotid Intima-media Thickness in Patients with Rheumatoid Arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Carotid Artery Diseases; Carotid Intima-Media Thickness; Causality; Comorbidity; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Reproducibility of Results; Republic of Korea; Risk Factors; Sensitivity and Specificity | 2015 |
Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose-response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate to Validate inhibitory effect on bone Erosion (DRIVE)-a 12-month, multicentre, randomise
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Density Conservation Agents; Denosumab; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Rheumatoid Factor | 2016 |
Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Europe; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Synovitis; Treatment Outcome; Ultrasonography, Doppler | 2016 |
[Effect of Xinfeng Capsule on Lipoprotein Metabolism of Rheumatoid Arthritis Patients].
Topics: Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Capsules; Drugs, Chinese Herbal; Humans; Interleukin-10; Interleukin-6; Lipoproteins; Lipoproteins, HDL; Methotrexate | 2015 |
Association of Triple Therapy With Improvement in Cholesterol Profiles Over Two-Year Followup in the Treatment of Early Aggressive Rheumatoid Arthritis Trial.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cholesterol; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Methotrexate; Middle Aged | 2016 |
BAFF inhibition does not significantly impair immunization responses in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; B-Cell Activating Factor; B-Lymphocytes; Diphtheria-Tetanus-acellular Pertussis Vaccines; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoglobulins; Immunosuppressive Agents; Lymphocyte Count; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Vaccination | 2015 |
Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients.
Topics: Abatacept; Aged; Antibodies, Bacterial; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunity, Humoral; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Pneumonia, Pneumococcal | 2015 |
Safety and Efficacy of Subcutaneous Golimumab in Patients with Active Rheumatoid Arthritis despite Methotrexate Therapy: Final 5-year Results of the GO-FORWARD Trial.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2016 |
Discontinuation of etanercept after achievement of sustained remission in patients with rheumatoid arthritis who initially had moderate disease activity-results from the ENCOURAGE study, a prospective, international, multicenter randomized study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Republic of Korea; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2016 |
Opsonic and Antibody Responses to Pneumococcal Polysaccharide in Rheumatoid Arthritis Patients Receiving Golimumab Plus Methotrexate.
Topics: Aged; Antibodies, Monoclonal; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Monitoring; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Serogroup; Streptococcus pneumoniae; Treatment Outcome | 2015 |
Doubling the single-dose infusion rate of tocilizumab in rheumatoid arthritis is safe and efficacious.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Hypersensitivity; Edema; Fatigue; Female; Flushing; Glucocorticoids; Headache; Humans; Hypercholesterolemia; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Nasopharyngitis; Neutropenia; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study).
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Drug Substitution; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Severity of Illness Index; Treatment Outcome | 2016 |
Calprotectin (S100A8/A9) and S100A12 are associated with measures of disease activity in a longitudinal study of patients with rheumatoid arthritis treated with infliximab.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Calgranulin A; Calgranulin B; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Foot Joints; Glucocorticoids; Hand Joints; Humans; Infliximab; Leukocyte L1 Antigen Complex; Longitudinal Studies; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisolone; Prospective Studies; Radiography; Rheumatoid Factor; S100A12 Protein; Severity of Illness Index; Wrist Joint; Young Adult | 2016 |
[Treatment of Refractory Rheumatoid Arthritis by Huayu Tongbi Recipe Combined Methotrexate].
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Isoxazoles; Leflunomide; Methotrexate; Phytotherapy; Treatment Outcome | 2015 |
Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Early Diagnosis; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Single-Blind Method; Sulfasalazine; Time Factors; Treatment Outcome | 2016 |
Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Japan; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Time Factors; Treatment Outcome | 2016 |
Efficacy and Safety of Baricitinib in Japanese Patients with Active Rheumatoid Arthritis Receiving Background Methotrexate Therapy: A 12-week, Double-blind, Randomized Placebo-controlled Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Remission Induction; Severity of Illness Index; Sulfonamides; Symptom Assessment; Treatment Outcome | 2016 |
Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.
Topics: Adalimumab; Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; CD18 Antigens; Chronic Disease; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Mice, Inbred C57BL; Mice, Inbred Strains; Middle Aged; Synovial Fluid; Treatment Outcome | 2016 |
Sustained improvements in MRI outcomes with abatacept following the withdrawal of all treatments in patients with early, progressive rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Magnetic Resonance Imaging; Methotrexate; Osteitis; Remission Induction; Severity of Illness Index; Synovitis; Treatment Outcome | 2016 |
A phase III, multicentre, randomised, double-blind, active-controlled, parallel-group trial comparing safety and efficacy of HD203, with innovator etanercept, in combination with methotrexate, in patients with rheumatoid arthritis: the HERA study.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Therapeutic Equivalency; Treatment Outcome | 2017 |
A phase I pharmacokinetics trial comparing PF-05280586 (a potential biosimilar) and rituximab in patients with active rheumatoid arthritis.
Topics: Administration, Intravenous; Adult; Aged; Antibodies; Antigens, CD19; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Biosimilar Pharmaceuticals; Double-Blind Method; European Union; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Therapeutic Equivalency | 2016 |
Tofacitinib or adalimumab versus placebo: patient-reported outcomes from a phase 3 study of active rheumatoid arthritis.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Severity of Illness Index; Treatment Outcome | 2016 |
Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Propensity Score; Tacrolimus; Treatment Outcome | 2016 |
[Treatment of Rheumatoid Arthritis by Hebi Recipe: an Efficacy Observation].
Topics: Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Methotrexate; Phytotherapy; Rheumatoid Factor; Syndrome; Treatment Outcome | 2016 |
Efficacy and safety of low-dose tacrolimus for active rheumatoid arthritis with an inadequate response to methotrexate.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Calcineurin Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Remission Induction; Republic of Korea; Tacrolimus; Time Factors; Treatment Outcome | 2016 |
The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Interleukins; Leukocytes, Mononuclear; Male; Methotrexate; Microscopy, Confocal; Middle Aged; Osteoclasts; Receptors, Interleukin; Rheumatoid Factor | 2016 |
Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitati
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Marrow; Bone Marrow Diseases; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Synovitis; Treatment Outcome; Wrist Joint | 2016 |
Infliximab Versus Conventional Combination Treatment and Seven-Year Work Loss in Early Rheumatoid Arthritis: Results of a Randomized Swedish Trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Sick Leave; Sulfasalazine; Sweden; Time Factors; Treatment Outcome | 2016 |
Cost-Effectiveness of Triple Therapy Versus Etanercept Plus Methotrexate in Early Aggressive Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Etanercept; Female; Health Care Costs; Humans; Hydroxychloroquine; Male; Markov Chains; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Sulfasalazine; Time Factors | 2016 |
Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Foot; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Ultrasonography, Doppler; Wrist | 2016 |
Glucocorticoid Effect on Radiographic Progression in Placebo Arms of Rheumatoid Arthritis Biologics Trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Glucocorticoids; Humans; Infliximab; Joints; Methotrexate; Placebos; Treatment Outcome | 2016 |
Brief Report: Estimating Disease Activity Using Multi-Biomarker Disease Activity Scores in Rheumatoid Arthritis Patients Treated With Abatacept or Adalimumab.
Topics: Abatacept; Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate; Severity of Illness Index | 2016 |
Effect of adalimumab on the work-related outcomes scores in patients with early rheumatoid arthritis receiving methotrexate.
Topics: Absenteeism; Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Efficiency; Female; Humans; Male; Methotrexate; Middle Aged; Presenteeism; Severity of Illness Index; Treatment Outcome; Unemployment | 2016 |
PRTX-100 and methotrexate in patients with active rheumatoid arthritis: A Phase Ib randomized, double-blind, placebo-controlled, dose-escalation study.
Topics: Administration, Intravenous; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin E; Immunoglobulin G; Male; Methotrexate; South Africa; Staphylococcal Protein A; Treatment Outcome | 2014 |
Efficacy and safety of CT-P13 (biosimilar infliximab) in patients with rheumatoid arthritis: comparison between switching from reference infliximab to CT-P13 and continuing CT-P13 in the PLANETRA extension study.
Topics: Adolescent; Adult; Aged; Antibodies; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Substitution; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2017 |
Certolizumab pegol in combination with dose-optimised methotrexate in DMARD-naïve patients with early, active rheumatoid arthritis with poor prognostic factors: 1-year results from C-EARLY, a randomised, double-blind, placebo-controlled phase III study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Remission Induction | 2017 |
A randomized, controlled trial of efficacy and safety of Anbainuo, a bio-similar etanercept, for moderate to severe rheumatoid arthritis inadequately responding to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Immunoglobulin Fc Fragments; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Retreatment; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2016 |
Differential response of serum amyloid A to different therapies in early rheumatoid arthritis and its potential value as a disease activity biomarker.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Etanercept; Female; Humans; Immunoassay; Male; Methotrexate; Middle Aged; Serum Amyloid A Protein | 2016 |
Discordance between patient and physician assessments of global disease activity in rheumatoid arthritis and association with work productivity.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Efficiency; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Physicians; Severity of Illness Index; Work Performance | 2016 |
KIR2DL2 and KIR2DS2 as genetic markers to the methotrexate response in rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Female; Genetic Markers; Genotype; Humans; Male; Methotrexate; Middle Aged; Receptors, KIR; Receptors, KIR2DL2 | 2016 |
The Effect of Reduced or Withdrawn Etanercept-methotrexate Therapy on Patient-reported Outcomes in Patients with Early Rheumatoid Arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Remission Induction; Treatment Outcome | 2016 |
Tapering conventional synthetic DMARDs in patients with early arthritis in sustained remission: 2-year follow-up of the tREACH trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Remission Induction; Symptom Flare Up; Time Factors | 2016 |
Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2016 |
Methotrexate Dosage Reduction Upon Adalimumab Initiation: Clinical and Ultrasonographic Outcomes from the Randomized Noninferiority MUSICA Trial.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Ultrasonography | 2016 |
A Phase 1 Dose-Escalation Study of ASP2409, a Selective T-Cell Costimulation Inhibitor, in Stable Rheumatoid Arthritis Patients on Methotrexate Therapy.
Topics: Administration, Intravenous; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Half-Life; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 2016 |
A disintegrin and metalloprotease-17 and galectin-9 are important regulators of local 4-1BB activity and disease outcome in rheumatoid arthritis.
Topics: 4-1BB Ligand; ADAM17 Protein; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; CD8-Positive T-Lymphocytes; Cells, Cultured; Disease Progression; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Galectins; HEK293 Cells; Humans; Leukocytes, Mononuclear; Longitudinal Studies; Matrix Metalloproteinase 17; Methotrexate; Synovial Fluid; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2016 |
A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase 1; Male; Methotrexate; Middle Aged; Nausea; Protein Kinase Inhibitors; Respiratory Tract Infections; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha; Urinary Tract Infections | 2016 |
Efficacy and Safety of ABT-494, a Selective JAK-1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Hemoglobins; Herpes Zoster; Heterocyclic Compounds, 3-Ring; Humans; Hypercholesterolemia; Janus Kinase 1; Male; Methotrexate; Middle Aged; Pharyngitis; Protein Kinase Inhibitors; Treatment Outcome | 2016 |
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of ASP2408, a Potent Selective T-Cell Costimulation Modulator After Single and Multiple Ascending Doses in Healthy Volunteers and RA Patients.
Topics: Administration, Intravenous; Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; B7-2 Antigen; CTLA-4 Antigen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Half-Life; Humans; Immunoconjugates; Immunoglobulin G; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; T-Lymphocytes; Young Adult | 2016 |
Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Histamine Antagonists; Humans; Lymphohistiocytosis, Hemophagocytic; Methotrexate; Receptors, Histamine H4; Treatment Failure; Treatment Outcome | 2016 |
Effectiveness of methotrexate with step-down glucocorticoid remission induction (COBRA Slim) versus other intensive treatment strategies for early rheumatoid arthritis in a treat-to-target approach: 1-year results of CareRA, a randomised pragmatic open-la
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission Induction; Risk Factors; Severity of Illness Index; Sulfasalazine | 2017 |
Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Models, Statistical; Prednisone; Sulfasalazine | 2016 |
Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Synergism; Female; Humans; Male; Methotrexate; Middle Aged; Oxidation-Reduction; Ozone; Treatment Outcome | 2016 |
Oral Methotrexate in split dose weekly versus oral or parenteral Methotrexate once weekly in Rheumatoid Arthritis: a short-term study.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; India; Injections, Intramuscular; Intention to Treat Analysis; Male; Medication Adherence; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome | 2018 |
Improvement of High-Density Lipoprotein Function in Patients With Early Rheumatoid Arthritis Treated With Methotrexate Monotherapy or Combination Therapies in a Randomized Controlled Trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Lipoproteins, HDL; Male; Methotrexate; Middle Aged; Sulfasalazine | 2017 |
Best cost-effectiveness and worker productivity with initial triple DMARD therapy compared with methotrexate monotherapy in early rheumatoid arthritis: cost-utility analysis of the tREACH trial.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Female; Health Expenditures; Humans; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Single-Blind Method; Treatment Outcome | 2016 |
Sarilumab plus methotrexate improves patient-reported outcomes in patients with active rheumatoid arthritis and inadequate responses to methotrexate: results of a phase III trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Treatment Outcome | 2016 |
A multicentre randomised controlled trial to compare the pharmacokinetics, efficacy and safety of CT-P10 and innovator rituximab in patients with rheumatoid arthritis.
Topics: Adult; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Severity of Illness Index; Therapeutic Equivalency | 2017 |
Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study.
Topics: Adult; Aftercare; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Diabetes Complications; Double-Blind Method; Early Diagnosis; Female; Glucocorticoids; Humans; Infliximab; Insulin; Insulin Resistance; Lipid Metabolism; Male; Methotrexate; Methylprednisolone; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Risk Factors; Surveys and Questionnaires; Treatment Outcome; Young Adult | 2016 |
Optimizing therapy in inflammatory arthritis: prediction of relapse after tapering or stopping treatment for rheumatoid arthritis patients achieving clinical and radiological remission.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biological Products; Disease Progression; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Proportional Hazards Models; Prospective Studies; Recurrence; Remission Induction; Rheumatology; ROC Curve; Synovitis; Treatment Outcome; Ultrasonography | 2016 |
Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate: a biomarker study of MOBILITY.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Double-Blind Method; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Synovial Membrane; Treatment Outcome | 2016 |
Baricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease-Modifying Antirheumatic Drug Treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Purines; Pyrazoles; Sulfonamides | 2017 |
Efficacy of tofacitinib in patients with rheumatoid arthritis stratified by background methotrexate dose group.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinases; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Regression Analysis; Surveys and Questionnaires; Treatment Outcome | 2017 |
Peficitinib, a JAK Inhibitor, in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate.
Topics: Adamantane; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Janus Kinases; Male; Methotrexate; Middle Aged; Niacinamide; Severity of Illness Index; Treatment Outcome | 2017 |
Effect of a treat-to-target strategy based on methotrexate and intra-articular betamethasone with or without additional cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis:
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Betamethasone; Bone Diseases; Cyclosporine; Double-Blind Method; Drug Administration Routes; Drug Delivery Systems; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Patient Acuity; Synovitis; Tendinopathy; Treatment Outcome | 2017 |
Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Infusions, Intravenous; Lipoproteins, HDL; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2017 |
Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Headache; Humans; Infections; Injections; Male; Methotrexate; Middle Aged; Neutropenia; Remission Induction; Retreatment; Severity of Illness Index | 2017 |
Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE study.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Single-Blind Method | 2016 |
Safety and Efficacy of SBI-087, a Subcutaneous Agent for B Cell Depletion, in Patients with Active Rheumatoid Arthritis: Results from a Phase II Randomized, Double-blind, Placebo-controlled Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Lymphocyte Depletion; Male; Methotrexate; Middle Aged; Proteins; Treatment Outcome | 2016 |
Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1).
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Hemoglobins; Humans; Infections; Janus Kinase 1; Male; Methotrexate; Middle Aged; Protein Kinase Inhibitors; Pyridines; Severity of Illness Index; Surveys and Questionnaires; Triazoles | 2017 |
Filgotinib (GLPG0634/GS-6034), an oral selective JAK1 inhibitor, is effective as monotherapy in patients with active rheumatoid arthritis: results from a randomised, dose-finding study (DARWIN 2).
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemoglobins; Humans; Infections; Janus Kinase 1; Male; Methotrexate; Middle Aged; Protein Kinase Inhibitors; Pyridines; Retreatment; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Triazoles | 2017 |
Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events.
Topics: Abscess; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Gastritis; Gastrointestinal Diseases; Humans; Hydroxychloroquine; Ileus; Incidence; Infections; Intestinal Obstruction; Linear Models; Male; Methotrexate; Middle Aged; Pancreatitis; Pneumonia; Respiratory Tract Infections; Sulfasalazine; Urinary Tract Infections | 2017 |
Oral to subcutaneous methotrexate dose-conversion strategy in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2017 |
A randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Retreatment; Severity of Illness Index; Treatment Failure; Ustekinumab | 2017 |
Clinical benefit of 1-year certolizumab pegol (CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritis was observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Deprescriptions; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Retreatment; Treatment Outcome | 2017 |
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis.
Topics: Adalimumab; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Janus Kinases; Joints; Male; Methotrexate; Middle Aged; Protein Kinase Inhibitors; Purines; Pyrazoles; Radiography; Sulfonamides | 2017 |
A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Retreatment; Severity of Illness Index; Treatment Outcome | 2017 |
Early non-response to certolizumab pegol in rheumatoid arthritis predicts treatment failure at one year. Data from a randomised phase III clinical trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Treatment Failure | 2018 |
Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy.
Topics: Adalimumab; Antigens, CD; Arthritis, Rheumatoid; Biomarkers; CD83 Antigen; Dendritic Cells; Female; Humans; Immunoglobulins; Immunotherapy; Inflammation; Male; Membrane Glycoproteins; Methotrexate; Microscopy, Confocal; Middle Aged; Synovial Fluid; Synovial Membrane; Tumor Necrosis Factor-alpha | 2017 |
Improvements in clinical response between 12 and 24 weeks in patients with rheumatoid arthritis on etanercept therapy with or without methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis.
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chickens; Collagen Type II; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2008 |
Efficacy and safety of etanercept 50 mg twice a week in patients with rheumatoid arthritis who had a suboptimal response to etanercept 50 mg once a week: results of a multicenter, randomized, double-blind, active drug-controlled study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2008 |
[Comparison of efficacy and tolerability of triple combination therapy (methotrexate + sulfasalazine + hydroxychloroquine) with methotrexate monotherapy in patients with rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Pain Measurement; Remission Induction; Sulfasalazine; Treatment Outcome | 2008 |
Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: the impacts of remission and tumour necrosis factor blockade.
Topics: Adult; Analysis of Variance; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Adjunctive anakinra in patients with active rheumatoid arthritis despite methotrexate, or leflunomide, or cyclosporin-A monotherapy: a 48-week, comparative, prospective study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2008 |
Comment on: Use of parenteral methotrexate significantly reduces the need for biological therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Prospective Studies; Treatment Outcome | 2008 |
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Severity of Illness Index; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Collagen Type II; Drug Administration Schedule; Drug Therapy, Combination; Feasibility Studies; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Pilot Projects; Prednisolone; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2008 |
Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2008 |
Differential effect on symptoms treated with traditional Chinese medicine and western combination therapy in RA patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Endpoint Determination; Female; Humans; Male; Methotrexate; Middle Aged; Single-Blind Method; Sulfasalazine | 2008 |
Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis.
Topics: Acute Disease; Aged; Analysis of Variance; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Joints; Linear Models; Male; Methotrexate; Middle Aged; Prednisone; Remission Induction; Sulfasalazine; Treatment Outcome | 2009 |
A comparison study of a recombinant tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) and methotrexate in treatment of patients with active rheumatoid arthritis in China.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; China; Double-Blind Method; Etanercept; Female; Humans; Immunoglobulin G; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Treatment Outcome; Young Adult | 2009 |
Inhibition of radiographic progression with combination etanercept and methotrexate in patients with moderately active rheumatoid arthritis previously treated with monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2009 |
Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I/II randomized, blinded, placebo-controlled, dose-ranging study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoglobulin M; Immunologic Factors; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Patient Selection; Remission Induction; Severity of Illness Index; Treatment Outcome | 2008 |
Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Counseling; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Patient Compliance; Patient Satisfaction; Pilot Projects; Sulfasalazine; Young Adult | 2009 |
[Clinical randomized study of bee-sting therapy for rheumatoid arthritis].
Topics: Acupuncture Points; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bee Venoms; Female; Humans; Male; Meloxicam; Methotrexate; Middle Aged; Recurrence; Sulfasalazine; Thiazines; Thiazoles | 2008 |
Effect of the early use of the anti-tumor necrosis factor adalimumab on the prevention of job loss in patients with early rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Early Diagnosis; Employment; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Clinical outcome and B cell depletion in patients with rheumatoid arthritis receiving rituximab monotherapy in comparison with patients receiving concomitant methotrexate.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Drug Therapy, Combination; Humans; Lymphocyte Depletion; Methotrexate; Rituximab; Treatment Outcome | 2008 |
Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Recovery of Function; Treatment Outcome | 2009 |
Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Foot Joints; Hand Joints; Humans; Infliximab; Methotrexate; Middle Aged; Radiography; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial.
Topics: Administration, Oral; Adult; Aged; Aminopyridines; Arthritis, Rheumatoid; Double-Blind Method; Humans; Interleukin-6; Intracellular Signaling Peptides and Proteins; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Morpholines; Oxazines; Prodrugs; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Syk Kinase | 2008 |
Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Radiography | 2008 |
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition t
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Treatment Outcome; Vascular Endothelial Growth Factor A; Young Adult | 2009 |
Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: a Phase I, open-label, dose-escalation clinical study.
Topics: Adult; Aged; Antigens, CD19; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; B-Lymphocytes; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Peptides; Young Adult | 2008 |
Efficacy and safety of certolizumab pegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study. A randomised controlled trial.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Arthrography; Blood Coagulation; Certolizumab Pegol; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Male; Methotrexate; Polyethylene Glycols; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Golimumab, a human antibody to tumour necrosis factor {alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study.
Topics: Acute Disease; Adult; Analysis of Variance; Antibodies, Monoclonal; Arthritis, Rheumatoid; Bacterial Infections; Chi-Square Distribution; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Evaluation of different methods used to assess disease activity in rheumatoid arthritis: analyses of abatacept clinical trial data.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Discriminant Analysis; Disease Progression; Double-Blind Method; Humans; Immunoconjugates; Methotrexate; Patient Satisfaction; Treatment Outcome | 2009 |
Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pain Measurement; Patients; Prednisone; Quality of Life; Severity of Illness Index; Treatment Outcome | 2009 |
Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prognosis; Quality of Life; Radiography; Treatment Outcome | 2009 |
Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; p38 Mitogen-Activated Protein Kinases; Pyridones; Pyrimidines; Severity of Illness Index; Treatment Outcome | 2009 |
Patients with moderate rheumatoid arthritis (RA) achieve better disease activity states with etanercept treatment than patients with severe RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index | 2009 |
Safety and efficacy of the selective costimulation modulator abatacept in patients with rheumatoid arthritis receiving background methotrexate: a 5-year extended phase IIB study.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Placebos; Quality of Life; Treatment Outcome | 2009 |
Relapse-remission and remission-relapse switches in rheumatoid arthritis patients were modeled by random effects.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Models, Statistical; Prednisolone; Recurrence; Remission Induction; Sulfasalazine; Treatment Outcome | 2009 |
[Isoniazid prophylaxis for pulmonary tuberculosis in Chinese patients with rheumatoid arthritis receiving long-term methotrexate therapy].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemoprevention; Humans; Immunosuppressive Agents; Isoniazid; Methotrexate; Middle Aged; Time Factors; Tuberculosis, Pulmonary; Young Adult | 2009 |
Patient-reported outcomes improve with etanercept plus methotrexate in active early rheumatoid arthritis and the improvement is strongly associated with remission: the COMET trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome | 2010 |
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Severity of Illness Index; Treatment Outcome | 2010 |
Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridones; Pyrimidines; Severity of Illness Index; Treatment Outcome; Young Adult | 2010 |
Long-term efficacy and toxicity of ciclosporin A in combination with methotrexate in poor prognosis rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prognosis; Treatment Outcome | 2009 |
Randomized, double-blind, placebo-controlled, comparative study of human anti-TNF antibody adalimumab in combination with methotrexate and methotrexate alone in Taiwanese patients with active rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Taiwan; Treatment Outcome | 2009 |
Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2009 |
Bone loss in patients with active early rheumatoid arthritis: infliximab and methotrexate compared with methotrexate treatment alone. Explorative analysis from a 12-month randomised, double-blind, placebo-controlled study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Osteoporosis | 2009 |
Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Carotid Artery Diseases; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha; Tunica Intima; Tunica Media; Ultrasonography | 2009 |
Rheumatoid arthritis joint progression in sustained remission is determined by disease activity levels preceding the period of radiographic assessment.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Humans; Methotrexate; Radiography; Time Factors | 2009 |
The good initial response to therapy with a combination of traditional disease-modifying antirheumatic drugs is sustained over time: the eleven-year results of the Finnish rheumatoid arthritis combination therapy trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisolone; Sulfasalazine; Treatment Outcome | 2009 |
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Receptors, Tumor Necrosis Factor, Type I; Serum Amyloid A Protein; Treatment Outcome; Tumor Necrosis Factor Decoy Receptors | 2009 |
Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Andrographis; Arsenicals; Arthralgia; Arthritis, Rheumatoid; Chloroquine; Double-Blind Method; Drug Therapy, Combination; Female; Glutathione; Humans; Methotrexate; Middle Aged; Phytotherapy; Placebos; Plant Extracts; Plant Leaves; Prednisone; Prospective Studies; Radiography; Severity of Illness Index; Young Adult | 2009 |
Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Prospective Studies; Ribonucleosides; Severity of Illness Index; Surveys and Questionnaires | 2009 |
Survival, comorbidities and joint damage 11 years after the COBRA combination therapy trial in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Sulfasalazine; Treatment Outcome | 2010 |
Are glucocorticoids a consistent risk factor for infections in rheumatoid arthritis patients under treatment with methotrexate and etanercept?
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bacterial Infections; Candidiasis, Vulvovaginal; Disease Susceptibility; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunocompromised Host; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Otitis Media; Receptors, Tumor Necrosis Factor; Respiratory Tract Infections; Urinary Tract Infections | 2009 |
E-selectin, interleukin 18, serum amyloid a, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; E-Selectin; Female; Humans; Injections, Subcutaneous; Interleukin-18; Male; Matrix Metalloproteinase 9; Methotrexate; Middle Aged; Serum Amyloid A Protein; Tissue Inhibitor of Metalloproteinase-1 | 2009 |
Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): a multicentre, randomised, double-blind, placebo-controlled, phase III trial.
Topics: Adalimumab; Analysis of Variance; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; Safety; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Benzopyrans; China; Double-Blind Method; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Methotrexate; Middle Aged; Sulfonamides; Treatment Outcome | 2009 |
Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Therapy, Computer-Assisted; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 2010 |
A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Rheumatoid Factor; Treatment Outcome | 2009 |
Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients with rheumatoid arthritis: results from the RISING study.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Health Status; Humans; Infliximab; Male; Methotrexate; Middle Aged; Patient Selection; Prospective Studies; Surveys and Questionnaires; Treatment Outcome | 2009 |
Methotrexate therapy in rheumatoid arthritis after failure to sulphasalazine: to switch or to add?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Patient Selection; Sulfasalazine; Treatment Failure; Treatment Outcome | 2009 |
Golimumab, a human anti-tumor necrosis factor alpha monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-bli
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Health Status; Humans; Injections, Subcutaneous; Joints; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2009 |
[Combined basic therapy of rheumatoid arthritis with methotrexate and plaquenil].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Young Adult | 2009 |
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
The effect of etanercept on work productivity in patients with early active rheumatoid arthritis: results from the COMET study.
Topics: Absenteeism; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Efficiency; Employment; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2009 |
Benefit of anti-TNF therapy in rheumatoid arthritis patients with moderate disease activity.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Effectiveness and retention rates of methotrexate in psoriatic arthritis in comparison with methotrexate-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Administration Schedule; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Male; Medication Adherence; Methotrexate; Middle Aged; Patient Dropouts; Quality of Life; Treatment Outcome | 2010 |
Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Recovery of Function; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Examination of the effect of increasing doses of etoricoxib on oral methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Etoricoxib; Female; Humans; Male; Methotrexate; Middle Aged; Pyridines; Sulfones | 2009 |
Repair of erosions occurs almost exclusively in damaged joints without swelling.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Regeneration; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Foot Joints; Hand Joints; Humans; Immunoglobulin G; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor | 2010 |
Effect of certolizumab pegol with methotrexate on home and work place productivity and social activities in patients with active rheumatoid arthritis.
Topics: Absenteeism; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost of Illness; Drug Therapy, Combination; Efficiency; Employment; Female; Humans; Immunoglobulin Fab Fragments; Leisure Activities; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Social Behavior | 2009 |
Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled
Topics: Activities of Daily Living; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Fatigue; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Polyethylene Glycols; Quality of Life; Recovery of Function; Severity of Illness Index | 2009 |
MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Receptors, CCR1; Treatment Outcome; Young Adult | 2009 |
A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chickens; Collagen Type II; Desensitization, Immunologic; Double-Blind Method; Female; Humans; Immune Tolerance; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2009 |
[Efficacy and safety of infliximab in patients with rheumatoid arthritis].
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prospective Studies; Young Adult | 2009 |
[Effects of wenhua juanbi recipe on TNF-alpha and IL-1beta in peripheral blood of rheumatoid arthritis patients].
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Interleukin-1beta; Male; Meloxicam; Methotrexate; Middle Aged; Phytotherapy; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibody Formation; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocyte Subsets; Drug Therapy, Combination; Female; Hemocyanins; Humans; Hypersensitivity, Delayed; Immunologic Memory; Influenza Vaccines; Lymphocyte Count; Lymphocyte Depletion; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Rituximab; Skin Tests; Tetanus Toxoid; Vaccines; Young Adult | 2010 |
Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of th
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biomarkers; Cartilage, Articular; Chondrogenesis; Collagen Type I; Collagen Type II; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Health Status; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Osteocalcin; Osteogenesis; Peptide Fragments; Peptides; Procollagen | 2010 |
[Adalimumab plus methotrexate for the treatment of rheumatoid arthritis: a multi-center randomized, double-blind, placebo-controlled clinical study.].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Quality of Life; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmunity; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Risk; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
[Efficacy of Shenshi Qianghuo Dihuang Decoction in rheumatoid arthritis: a randomized controlled trial].
Topics: Adult; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Treatment Outcome | 2010 |
A proof-of-concept and drug-drug interaction study of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; p38 Mitogen-Activated Protein Kinases; Pyridones; Pyrimidines; Treatment Outcome | 2010 |
The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable b
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Estrogen Receptor alpha; Female; Humans; Medication Adherence; Methotrexate; Middle Aged; Placebos; Postmenopause; Steroids; Sulfasalazine; Treatment Failure | 2010 |
Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Erythrocyte Count; Erythrocytes; Female; Folic Acid; Glutamic Acid; Humans; Joints; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Young Adult | 2010 |
LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study.
Topics: Adolescent; Adult; Age of Onset; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Blood Sedimentation; Disabled Persons; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infusions, Intravenous; Interleukin-17; Male; Methotrexate; Middle Aged; Patient Selection | 2010 |
Golimumab, a new human anti-tumor necrosis factor alpha antibody, administered intravenously in patients with active rheumatoid arthritis: Forty-eight-week efficacy and safety results of a phase III randomized, double-blind, placebo-controlled study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Patient Selection; Placebos; Safety; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Does gastrointestinal adverse drug reaction influence therapeutic effect in the treatment of rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Gastrointestinal Diseases; Humans; Methotrexate; Sulfasalazine; Treatment Outcome | 2010 |
Two-year clinical and radiographic results with combination etanercept-methotrexate therapy versus monotherapy in early rheumatoid arthritis: a two-year, double-blind, randomized study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2010 |
Improvement in work place and household productivity for patients with early rheumatoid arthritis treated with adalimumab plus methotrexate: work outcomes and their correlations with clinical and radiographic measures from a randomized controlled trial co
Topics: Absenteeism; Adalimumab; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Efficiency; Employment; Family Characteristics; Female; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Radiography; Workplace; Young Adult | 2010 |
Efficacy and safety of retreatment in patients with rheumatoid arthritis with previous inadequate response to tumor necrosis factor inhibitors: results from the SUNRISE trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Odds Ratio; Rituximab; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Retrospective clinical study of the efficacy of lower-dose methotrexate and infliximab therapy in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Health Status; Humans; Infliximab; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2010 |
Co-administration of the JAK inhibitor CP-690,550 and methotrexate is well tolerated in patients with rheumatoid arthritis without need for dose adjustment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Outcome | 2010 |
[Clinical efficacy of Corydalis composite combined with methotrexate in treating rheumatoid arthritis].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Corydalis; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2009 |
Early disease control by low-dose prednisone comedication may affect the quality of remission in patients with early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Prednisone; Remission Induction; Surveys and Questionnaires; Time Factors | 2010 |
The AMBITION trial: tocilizumab monotherapy for rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Double-Blind Method; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Neutropenia; Receptors, Interleukin-6; Treatment Outcome | 2010 |
Response times follow lognormal or gamma distribution in arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Etanercept; Germany; Humans; Immunoglobulin G; Male; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Registries; Remission Induction; Time Factors; Treatment Outcome | 2010 |
Continued inhibition of structural damage over 2 years in patients with rheumatoid arthritis treated with rituximab in combination with methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: 52-week results of the GO-FORWARD study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Severity of Illness Index; Treatment Outcome | 2010 |
Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Bone Marrow Diseases; Cyclosporine; Disease Progression; Drug Therapy, Combination; Edema; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prognosis; Radiography; Remission Induction | 2010 |
Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Pressure; Body Mass Index; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Prednisone; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2010 |
Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis.
Topics: Absorptiometry, Photon; Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Bone Density; Disease Progression; Drug Therapy, Combination; Female; Foot; Hand; Humans; Infliximab; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisone; Sensitivity and Specificity; Sulfasalazine | 2010 |
Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Effi
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Severity of Illness Index; Treatment Outcome | 2010 |
A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Glucocorticoids; Humans; Infliximab; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisone; Radiography; Rheumatoid Factor | 2010 |
Validity of the disease activity score in undifferentiated arthritis.
Topics: Adult; Aged; Arthritis; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2010 |
The impact of Rituximab therapy on the chromosomes of patients with Rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Chromosomes; Female; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Prospective Studies; Rituximab | 2010 |
Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2010 |
[Clinical study on active rheumatoid arthritis treated with simiao xiaobi decoction].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy | 2010 |
Etanercept (ETN) with methotrexate (MTX) is better than ETN monotherapy in patients with active rheumatoid arthritis despite MTX therapy: a randomized trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Recovery of Function; Treatment Outcome; Withholding Treatment | 2010 |
Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Finland; Follow-Up Studies; Foot Joints; Hand Joints; Humans; Hydroxychloroquine; Longitudinal Studies; Methotrexate; Prednisolone; Radiography; Sulfasalazine; Treatment Outcome | 2010 |
Benefits 8 years after a remission induction regime with an infliximab and methotrexate combination in early rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Quality of Life; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Infliximab reduces the frequency of interleukin 17-producing cells and the amounts of interleukin 17 in patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Female; Flow Cytometry; Humans; Infliximab; Interleukin-17; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Th17 Cells; Treatment Outcome | 2010 |
Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Foot Joints; Hand Joints; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Single-Blind Method; Synovitis; Treatment Outcome; Young Adult | 2010 |
Population approach for exposure-response modeling of golimumab in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Injections; Likelihood Functions; Male; Methotrexate; Middle Aged; Models, Biological; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
A latent variable approach for modeling categorical endpoints among patients with rheumatoid arthritis treated with golimumab plus methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Endpoint Determination; Humans; Methotrexate; Models, Biological; Treatment Outcome | 2010 |
Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzeneacetamides; CCR5 Receptor Antagonists; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Sulfonamides; Treatment Outcome | 2010 |
Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Hand Joints; Humans; Infliximab; Male; Methotrexate; Middle Aged; Osteoarthritis; Radiography; Tumor Necrosis Factor-alpha | 2010 |
Well controlled, double-blind, placebo-controlled trials of classical Ayurvedic treatment are possible in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Medicine, Ayurvedic; Methotrexate; Middle Aged; Young Adult | 2011 |
Effects of different medical treatments on serum copper, selenium and zinc levels in patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chloroquine; Copper; Female; Humans; Male; Methotrexate; Middle Aged; Selenium; Sulfasalazine; Zinc | 2011 |
American College of Rheumatology hybrid analysis of certolizumab pegol plus methotrexate in patients with active rheumatoid arthritis: data from a 52-week phase III trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Polyethylene Glycols; Rheumatology; Societies, Medical; United States | 2011 |
Effect of intra-articular corticosteroid injections and inflammation on periarticular and generalised bone loss in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Diseases, Metabolic; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Male; Metacarpophalangeal Joint; Methotrexate; Methylprednisolone; Middle Aged; Treatment Outcome | 2011 |
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Morpholines; Oxazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Statistics, Nonparametric; Syk Kinase; Treatment Outcome | 2010 |
Disease activity, physical function, and radiographic progression after longterm therapy with adalimumab plus methotrexate: 5-year results of PREMIER.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Joints; Male; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Rituximab; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Health Status; Humans; Japan; Joints; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomised study over 21 months.
Topics: Absorptiometry, Photon; Adiponectin; Adipose Tissue; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Apolipoproteins; Arthritis, Rheumatoid; Body Composition; Bone Density; Bone Remodeling; Female; Humans; Hydroxychloroquine; Infliximab; Insulin-Like Growth Factor I; Leptin; Male; Methotrexate; Middle Aged; Radioimmunoassay; Sulfasalazine | 2010 |
No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study.
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Synovitis; Tomography, X-Ray Computed; Treatment Outcome; Tumor Necrosis Factor-alpha; Ultrasonography | 2011 |
Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis.
Topics: Adiponectin; Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Atorvastatin; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Methotrexate; Middle Aged; Prednisone; Pyrroles; Regional Blood Flow; Resistin; Risk Factors; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2011 |
Gene profiling predicts rheumatoid arthritis responsiveness to IL-1Ra (anakinra).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Gene Expression Profiling; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Treatment Outcome; Validation Studies as Topic | 2011 |
Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisone; Recurrence; Remission Induction; Severity of Illness Index; Treatment Outcome | 2011 |
Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Enzyme-Linked Immunosorbent Assay; Humans; Methotrexate | 2010 |
[An open-label, multicentric clinical trial to evaluate the efficacy and impact on bone metabolism of recombinant human tumor necrosis factor-α receptor II IgG Fc fusion protein with methotrexate in active rheumatoid arthritis: 24-week clinical and radiog
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Treatment Outcome | 2010 |
Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisolone; Prognosis; Remission Induction; Sex Factors; Smoking; Treatment Outcome | 2011 |
A multicentre trial of bucillamine in the treatment of early rheumatoid arthritis (SNOW study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Cysteine; Early Diagnosis; Female; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Remission Induction; Treatment Outcome; Young Adult | 2011 |
Fostamatinib, a Syk-kinase inhibitor, does not affect methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Syk Kinase | 2011 |
Leflunomide or methotrexate? Comparison of clinical efficacy and safety in low socio-economic rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Diarrhea; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Nausea; Severity of Illness Index; Social Class; Treatment Outcome | 2011 |
Disease activity score-driven therapy versus routine care in patients with recent-onset active rheumatoid arthritis: data from the GUEPARD trial and ESPOIR cohort.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Radiography; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
[Effect of Bizhongxiao decoction on proteomics of peripheral blood mononuclear cells in patients with rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Drugs, Chinese Herbal; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytotherapy; Proteome; Proteomics | 2010 |
Clinical consequences of delayed addition of adalimumab to methotrexate therapy over 5 years in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Time Factors; Treatment Outcome | 2011 |
Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pakistan; Practice Patterns, Physicians'; Prospective Studies; Remission Induction; Rheumatology; Severity of Illness Index; Treatment Outcome | 2011 |
The effects of golimumab on radiographic progression in rheumatoid arthritis: results of randomized controlled studies of golimumab before methotrexate therapy and golimumab after methotrexate therapy.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Treatment Outcome | 2011 |
Efficacy and safety of additional use of tacrolimus in patients with early rheumatoid arthritis with inadequate response to DMARDs--a multicenter, double-blind, parallel-group trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sulfasalazine; Tacrolimus; Treatment Outcome | 2011 |
Adalimumab reduces hand bone loss in rheumatoid arthritis independent of clinical response: subanalysis of the PREMIER study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Hand Bones; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structu
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Placebos; Radiography; Severity of Illness Index; Treatment Outcome | 2011 |
Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: results from a randomized controlled trial.
Topics: Acute Disease; Adalimumab; Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Placebos; Receptors, Tumor Necrosis Factor; Rituximab; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
Rapid improvement in the signs and symptoms of rheumatoid arthritis following certolizumab pegol treatment predicts better longterm outcomes: post-hoc analysis of a randomized controlled trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Humans; Immunoglobulin Fab Fragments; Longitudinal Studies; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Prognosis; Radiography; Treatment Outcome | 2011 |
Early clinical response to treatment predicts 5-year outcome in RA patients: follow-up results from the CAMERA study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Disease Progression; Drug Therapy, Computer-Assisted; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2011 |
Certolizumab pegol plus methotrexate provides broad relief from the burden of rheumatoid arthritis: analysis of patient-reported outcomes from the RAPID 2 trial.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epidemiologic Methods; Fatigue; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Polyethylene Glycols; Quality of Life; Treatment Outcome | 2011 |
The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prednisone; Quality of Life; Radiography; Remission Induction; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Flow Cytometry; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Odds Ratio; Recombinant Fusion Proteins; Treatment Outcome | 2011 |
Methotrexate chronotherapy is effective against rheumatoid arthritis.
Topics: Adult; Animals; Arthritis, Rheumatoid; Chronotherapy; Circadian Rhythm; Drug Chronotherapy; Humans; Immunoglobulin G; Immunosuppressive Agents; Leukocytes; Male; Methotrexate; Mice; Mice, Inbred MRL lpr; Rheumatoid Factor; RNA, Messenger; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
RAPID3 (Routine Assessment of Patient Index Data 3) severity categories and response criteria: Similar results to DAS28 (Disease Activity Score) and CDAI (Clinical Disease Activity Index) in the RAPID 1 (Rheumatoid Arthritis Prevention of Structural Damag
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disability Evaluation; Drug Combinations; Health Status Indicators; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Longitudinal Studies; Methotrexate; Outcome Assessment, Health Care; Polyethylene Glycols; Sensitivity and Specificity | 2011 |
Remission in early rheumatoid arthritis treated with conventional DMARDs. Results of a two-year follow-up study of El Ayachi Moroccan cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Health Status; HLA-DRB1 Chains; Humans; Hyperalgesia; Joints; Male; Methotrexate; Middle Aged; Morocco; Prednisone; Remission Induction; Severity of Illness Index; Young Adult | 2012 |
Very early rheumatoid arthritis is the major predictor of major outcomes: clinical ACR remission and radiographic non-progression.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Drug Therapy, Combination; Early Diagnosis; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Remission Induction; Sex Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and disease activity score-steered therapy: subanalysis of the BeSt study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Withholding Treatment | 2011 |
Efficacy of vitamin D in patients with active rheumatoid arthritis receiving methotrexate therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Severity of Illness Index; Treatment Outcome; Vitamin D | 2012 |
The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cartilage; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Radiography; Severity of Illness Index; Time; Treatment Outcome | 2011 |
Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Quality of Life; Recovery of Function; Rituximab; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2011 |
Continuation of methotrexate resulted in better clinical and radiographic outcomes than discontinuation upon starting etanercept in patients with rheumatoid arthritis: 52-week results from the JESMR study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Prospective Studies; Radiography; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2011 |
Double-blind, randomized, controlled, pilot study comparing classic ayurvedic medicine, methotrexate, and their combination in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Medicine, Ayurvedic; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Pilot Projects; Severity of Illness Index; Treatment Outcome | 2011 |
Subcutaneous abatacept versus intravenous abatacept: a phase IIIb noninferiority study in patients with an inadequate response to methotrexate.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Immunoconjugates; Injections, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2011 |
Association between tongue appearance in Traditional Chinese Medicine and effective response in treatment of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Color; Diagnosis, Differential; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Logistic Models; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Phytotherapy; Sulfasalazine; Tongue; Treatment Outcome | 2011 |
Evaluation of liver fibrosis by transient elastography in methotrexate treated patients.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Liver Cirrhosis; Logistic Models; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis; Sensitivity and Specificity; Single-Blind Method | 2011 |
Does achieving clinical response prevent work stoppage or work absence among employed patients with early rheumatoid arthritis?
Topics: Absenteeism; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Employment; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome | 2012 |
[Efficacy and safety of combination therapy with mizoribine and methotrexate for rheumatoid arthritis resistant with methotrexate].
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Ribonucleosides; Treatment Outcome | 2011 |
Efficacy and safety of CH-1504, a metabolically stable antifolate, in patients with active rheumatoid arthritis: results of a phase II multicenter randomized study.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2011 |
Efficacy and safety of the human anti-IL-1β monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, Phase II, dose-finding study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Interleukin-1beta; Male; Methotrexate; Middle Aged | 2011 |
Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Risk | 2011 |
Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Osteitis; Synovitis; Treatment Outcome; Wrist Joint | 2011 |
Sustained disease remission and inhibition of radiographic progression in methotrexate-naive patients with rheumatoid arthritis and poor prognostic factors treated with abatacept: 2-year outcomes.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
[Multi-center clinical study on therapeutic effect of kunxian capsule on rheumatoid arthritis].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Synergism; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Treatment Outcome | 2011 |
Antibody response is reduced following vaccination with 7-valent conjugate pneumococcal vaccine in adult methotrexate-treated patients with established arthritis, but not those treated with tumor necrosis factor inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Bacterial; Antibody Formation; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Spondylarthropathies; Streptococcus pneumoniae; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction ().
Topics: Adult; Arthritis, Rheumatoid; Disease Progression; Drugs, Chinese Herbal; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Radiography | 2012 |
Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Double-Blind Method; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Quality of Life; Severity of Illness Index; Treatment Outcome | 2011 |
Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoid arthritis who achieve radiographic nonprogression.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Opportunistic Infections; Quality of Life; Radiography; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2011 |
Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2012 |
Clinical response and tolerability to abatacept in patients with rheumatoid arthritis previously treated with infliximab or abatacept: open-label extension of the ATTEST Study.
Topics: Abatacept; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Retreatment with rituximab based on a treatment-to-target approach provides better disease control than treatment as needed in patients with rheumatoid arthritis: a retrospective pooled analysis.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Retreatment; Retrospective Studies; Rituximab; Treatment Outcome; Young Adult | 2011 |
Exploratory analyses of the association of MRI with clinical, laboratory and radiographic findings in patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome; Wrist Joint | 2011 |
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome | 2012 |
Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Separation; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein; Interleukin-17; Interleukin-1beta; Interleukins; Male; Methotrexate; Middle Aged; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2011 |
Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs.
Topics: Adalimumab; Administration, Oral; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Substitution; Drug Tolerance; Female; Health Status; Humans; Injections, Subcutaneous; Janus Kinase 3; Joints; Male; Methotrexate; Middle Aged; Pilot Projects; Piperidines; Pyrimidines; Pyrroles; Recovery of Function | 2012 |
Safety and effectiveness of rituximab in patients with rheumatoid arthritis following an inadequate response to 1 prior tumor necrosis factor inhibitor: the RESET Trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Predicting low disease activity and remission using early treatment response to antitumour necrosis factor therapy in patients with rheumatoid arthritis: exploratory analyses from the TEMPO trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Decision Trees; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
Sustained inhibition of progressive joint damage with rituximab plus methotrexate in early active rheumatoid arthritis: 2-year results from the randomised controlled trial IMAGE.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Radiography; Recovery of Function; Rituximab; Severity of Illness Index; Treatment Outcome; Young Adult | 2012 |
Treating to target matrix metalloproteinase 3 normalisation together with disease activity score below 2.6 yields better effects than each alone in rheumatoid arthritis patients: T-4 Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Young Adult | 2012 |
Health-related quality of life outcomes of adalimumab for patients with early rheumatoid arthritis: results from a randomized multicenter study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2012 |
Maintenance of efficacy and safety with subcutaneous golimumab among patients with active rheumatoid arthritis who previously received intravenous golimumab.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Humans; Injections, Intravenous; Injections, Subcutaneous; Methotrexate; Placebos; Safety; Treatment Outcome | 2011 |
Profile and course of early rheumatoid arthritis in Morocco: a two-year follow-up study.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Early Diagnosis; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Morocco; Prednisone; Prospective Studies; Young Adult | 2011 |
Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study.
Topics: Acute Disease; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Disease Progression; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2012 |
Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Humans; Immunologic Factors; Inflammation; Interleukin-6; Joints; Methotrexate; Middle Aged; Treatment Outcome | 2012 |
Blood memory B cells are disturbed and predict the response to rituximab in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Cell Activation Factor Receptor; B-Lymphocyte Subsets; Case-Control Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Lymphocyte Depletion; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Rituximab; Treatment Outcome; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2011 |
Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patients.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Osteitis; Synovitis; Treatment Outcome; Wrist Joint | 2011 |
A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chemokine CXCL10; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2012 |
Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study.
Topics: Adult; Age of Onset; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsules; Drug Administration Schedule; Female; Humans; Knee Joint; Methotrexate; Middle Aged; Nigella sativa; Phytotherapy; Placebos; Plant Oils; Seeds; Severity of Illness Index | 2012 |
Aggressive therapy in patients with early arthritis results in similar outcome compared with conventional care: the STREAM randomized trial.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Golimumab pharmacokinetics after repeated subcutaneous and intravenous administrations in patients with rheumatoid arthritis and the effect of concomitant methotrexate: an open-label, randomized study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Interactions; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Models, Biological; Treatment Outcome; Tumor Necrosis Factor-alpha; United States; Young Adult | 2012 |
Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrazones; Interleukin-12; Interleukin-23; Male; Methotrexate; Middle Aged; Morpholines; Pyrimidines; Treatment Outcome; Triazines | 2012 |
Safety and efficacy of various dosages of ocrelizumab in Japanese patients with rheumatoid arthritis with an inadequate response to methotrexate therapy: a placebo-controlled double-blind parallel-group study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Patient Safety; Treatment Failure; Treatment Outcome | 2012 |
Remission in early rheumatoid arthritis: predicting treatment response.
Topics: Age Factors; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Joints; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Remission Induction; Sensitivity and Specificity; Sex Factors; Treatment Outcome; United Kingdom | 2012 |
Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; CCR5 Receptor Antagonists; Constipation; Cyclohexanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Maraviroc; Metabolic Clearance Rate; Methotrexate; Middle Aged; Nausea; Treatment Failure; Triazoles; Young Adult | 2012 |
[One-year evaluation of radiographic progress in patients with rheumatoid arthritis treated by Qingre Huoxue decoction].
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Radiography | 2011 |
Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Dexamethasone; Double-Blind Method; Female; Glucocorticoids; Humans; Hydrolases; Immunohistochemistry; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Peptides; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synovial Membrane; Time Factors; Tissue Culture Techniques; Treatment Outcome; Triamcinolone Acetonide | 2012 |
Safety of rituximab in rheumatoid arthritis: a long-term prospective single-center study of gammaglobulin concentrations and infections.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; gamma-Globulins; Health Status; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Rituximab; Severity of Illness Index; Treatment Outcome | 2012 |
Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trial.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Infections; Infusions, Intravenous; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2012 |
A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate.
Topics: Analgesics; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Folic Acid; Health Status; Humans; Injections, Intravenous; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Remission Induction; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2012 |
Certolizumab pegol plus MTX administered every 4 weeks is effective in patients with RA who are partial responders to MTX.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Immunologic Factors; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Quality of Life; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult | 2012 |
Fcγ receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptors, IgG; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Radiography; Remission Induction; Treatment Outcome | 2012 |
IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522).
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Bone Resorption; C-Reactive Protein; Collagen Type I; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Osteocalcin; Osteogenesis; Peptides; Receptors, Interleukin-6; Tumor Necrosis Factor-alpha | 2012 |
Randomized comparison of etanercept with usual therapy in an Asian population with active rheumatoid arthritis: the APPEAL trial.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Asia; Asian People; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pacific Islands; Receptors, Tumor Necrosis Factor; Treatment Outcome; Young Adult | 2012 |
Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Drug Resistance; Drug Therapy, Combination; Female; Foot Bones; Hand Bones; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Tumor Necrosis Factor-alpha | 2012 |
Effects of double filtration plasmapheresis, leflunomide, and methotrexate on inflammatory changes found through magnetic resonance imaging in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Disability Evaluation; Early Diagnosis; Female; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Plasmapheresis; Quality of Life; Recovery of Function | 2012 |
Effect of golimumab on patient-reported outcomes in rheumatoid arthritis: results from the GO-FORWARD study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Drug Therapy, Combination; Fatigue; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Satisfaction; Quality of Life; Recovery of Function; Self Report; Surveys and Questionnaires; Treatment Outcome | 2012 |
A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2012 |
A randomized, double-blind, parallel, single-site pilot trial to compare two different starting doses of methotrexate in methotrexate-naïve adult patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Blood Sedimentation; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2012 |
Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Recovery of Function; Remission Induction | 2013 |
Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: analysis of the RISING Study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Interleukin-6; Methotrexate; Remission Induction | 2012 |
Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY).
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Female; Humans; Methotrexate; Middle Aged; Radiography | 2013 |
[Clinical study of Biqi Capsule combined with methotrexate for treatment of rheumatoid arthritis].
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Treatment Outcome; Young Adult | 2012 |
Low-dose oral prednisone improves clinical and ultrasonographic remission rates in early rheumatoid arthritis: results of a 12-month open-label randomised study.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Remission Induction; Treatment Outcome; Ultrasonography | 2012 |
Timing and magnitude of initial change in disease activity score 28 predicts the likelihood of achieving low disease activity at 1 year in rheumatoid arthritis patients treated with certolizumab pegol: a post-hoc analysis of the RAPID 1 trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Severity of Illness Index; Treatment Outcome | 2012 |
Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Humans; Methotrexate; Radiography; ROC Curve | 2012 |
Sustained efficacy of certolizumab pegol added to methotrexate in the treatment of rheumatoid arthritis: 2-year results from the RAPID 1 trial.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Certolizumab Pegol; Disability Evaluation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Health Status; Humans; Immunoglobulin Fab Fragments; Joints; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Recovery of Function; Severity of Illness Index; Time Factors; Treatment Outcome | 2012 |
Relations of serum COMP to cardiovascular risk factors and endothelial function in patients with rheumatoid arthritis treated with methotrexate and TNF-α inhibitors.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cartilage Oligomeric Matrix Protein; Drug Therapy, Combination; Endothelium, Vascular; Extracellular Matrix Proteins; Female; Glucocorticoids; Glycoproteins; Humans; Hyperemia; Male; Matrilin Proteins; Methotrexate; Middle Aged; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Intravenous golimumab is effective in patients with active rheumatoid arthritis despite methotrexate therapy with responses as early as week 2: results of the phase 3, randomised, multicentre, double-blind, placebo-controlled GO-FURTHER trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2013 |
Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Induction Chemotherapy; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Recovery of Function; Sulfasalazine | 2013 |
Phase II dose-response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Immunoconjugates; Japan; Methotrexate; Retreatment; Treatment Outcome | 2013 |
Serum cotinine as a biomarker of tobacco exposure and the association with treatment response in early rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cotinine; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Longitudinal Studies; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Smoking; Sulfasalazine; Treatment Outcome | 2012 |
Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Induction Chemotherapy; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Treatment Outcome | 2013 |
Infliximab for 6 months added on combination therapy in early rheumatoid arthritis: 2-year results from an investigator-initiated, randomised, double-blind, placebo-controlled study (the NEO-RACo Study).
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Early Medical Intervention; Female; Humans; Hydroxychloroquine; Induction Chemotherapy; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prednisolone; Sulfasalazine; Treatment Outcome | 2013 |
Improvements in health-related quality of life after treatment with tocilizumab in patients with rheumatoid arthritis refractory to tumour necrosis factor inhibitors: results from the 24-week randomized controlled RADIATE study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Quality of Life; Treatment Outcome | 2012 |
Increase of body mass index in a tight controlled methotrexate-based strategy with prednisone in early rheumatoid arthritis: side effect of the prednisone or better control of disease activity?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Patient Acceptance of Health Care; Prednisone; Prospective Studies; Treatment Outcome; Weight Gain | 2013 |
Comparative study on methotrexate and hydroxychloroquine in the treatment of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Middle Aged | 2012 |
Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfonamides; Treatment Outcome | 2013 |
Etanercept normalises left ventricular mass in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Echocardiography; Etanercept; Female; Humans; Hypertrophy, Left Ventricular; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Pulse Wave Analysis; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha; Vascular Stiffness | 2013 |
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Janus Kinase 3; Least-Squares Analysis; Leukocyte Count; Lipoproteins; Male; Methotrexate; Middle Aged; Neutrophils; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2012 |
Association of joint space narrowing with impairment of physical function and work ability in patients with early rheumatoid arthritis: protection beyond disease control by adalimumab plus methotrexate.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Employment; Female; Foot Joints; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome; Work Capacity Evaluation | 2013 |
Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Injections, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Osteitis; Synovitis; Treatment Outcome; Wrist Joint | 2013 |
Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Progression; Drug Therapy, Combination; Female; Flow Cytometry; GPI-Linked Proteins; Granulocytes; Humans; Infliximab; Leukocyte Count; Leukocytes; Lipopolysaccharide Receptors; Male; Methotrexate; Methylprednisolone; Middle Aged; Monocytes; Receptors, IgG; Tumor Necrosis Factor-alpha | 2012 |
A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Biomarkers, Pharmacological; Drug Therapy, Combination; Female; Genotype; Humans; Japan; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Precision Medicine; Reduced Folate Carrier Protein | 2013 |
A study on the selection of DMARDs for the combination therapy with adalimumab.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged | 2012 |
A merged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Probability; Radiography; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor | 2013 |
Infliximab is associated with improvement in arterial stiffness in patients with early rheumatoid arthritis -- a randomized trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Blood Flow Velocity; Carotid Intima-Media Thickness; Drug Substitution; Drug Therapy, Combination; Female; Health Status; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Pulse Wave Analysis; Severity of Illness Index; Treatment Failure; Vascular Stiffness | 2012 |
A phase 3 randomized, double-blind, multicenter comparative study evaluating the effect of etanercept versus methotrexate on radiographic outcomes, disease activity, and safety in Japanese subjects with active rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Etanercept; Female; Humans; Immunoglobulin G; Japan; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2013 |
Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied?
Topics: Absorptiometry, Photon; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Density Conservation Agents; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Glucocorticoids; Hip Joint; Humans; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Osteoporosis; Prednisone; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2013 |
Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or more tumor necrosis factor inhibitors: 5-year data from the REFLEX study.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Rituximab; Surveys and Questionnaires; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
A multicenter, randomized, double-blind clinical trial of combination therapy with Anbainuo, a novel recombinant human TNFRII:Fc fusion protein, plus methotrexate versus methotrexate alone or Anbainuo alone in Chinese patients with moderate to severe rheu
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; China; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Hyperalgesia; Immunoglobulin Fc Fragments; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Severity of Illness Index | 2013 |
Anti-TNF-α therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunoglobulin G; Interleukin-2 Receptor alpha Subunit; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Remission Induction; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Immunogenicity, safety, and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: results from a phase III, international, multicenter, parallel-arm, open-label study.
Topics: Abatacept; Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Immunogenetic Phenomena; Injections, Subcutaneous; Internationality; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunoglobulins; International Cooperation; Male; Methotrexate; Middle Aged; Opportunistic Infections; Rituximab | 2013 |
Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Placebos; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Treatment Failure | 2013 |
Methotrexate polyglutamation in relation to infliximab pharmacokinetics in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Neutralizing; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, Liquid; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Polyglutamic Acid | 2013 |
Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: findings of a phase IIIb, multinational, prospective, randomized study.
Topics: Abatacept; Adalimumab; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult | 2013 |
Impact of a multi-biomarker disease activity test on rheumatoid arthritis treatment decisions and therapy use.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged | 2013 |
A preliminary investigation of cognitive function in rheumatoid arthritis patients on long-term methotrexate treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cognition; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Neuropsychological Tests; Time Factors | 2013 |
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in early rheumatoid arthritis: 2-year quality-of-life results of the randomised, controlled, SWEFOT trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Infliximab; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Clinical and ultrasound-based composite disease activity indices in rheumatoid arthritis: results from a multicenter, randomized study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Europe; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Physical Examination; Prospective Studies; Receptors, Tumor Necrosis Factor; Reproducibility of Results; Severity of Illness Index; Treatment Outcome; Ultrasonography, Doppler | 2013 |
Risk of alanine transferase (ALT) elevation in patients with rheumatoid arthritis treated with methotrexate in a DAS-steered strategy.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Risk; Time Factors; Treatment Outcome | 2013 |
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Health Status; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Young Adult | 2013 |
Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; B-Cell Activating Factor; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Health Status; Humans; Injections, Intravenous; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2013 |
Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2013 |
Latent variable indirect response modeling of categorical endpoints representing change from baseline.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Logistic Models; Methotrexate; Models, Biological; Placebo Effect | 2013 |
Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Janus Kinases; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Pain Measurement; Piperidines; Pyrimidines; Pyrroles; Recurrence; Risk Assessment; Severity of Illness Index; Time Factors; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Improved health outcomes with etanercept versus usual DMARD therapy in an Asian population with established rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Asia; Asian People; Disability Evaluation; Drug Therapy, Combination; Emotions; Etanercept; Female; Humans; Immunoglobulin G; Male; Mental Health; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Receptors, Tumor Necrosis Factor; Recovery of Function; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2013 |
Effects of golimumab, an anti-tumour necrosis factor-α human monoclonal antibody, on lipids and markers of inflammation.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Lipids; Male; Methotrexate; Middle Aged; Placebos; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Adalimumab, a human anti-TNF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Secondary Prevention; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2014 |
Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Neoplasms; Radiography; Severity of Illness Index; Sickness Impact Profile; Surveys and Questionnaires; Treatment Outcome | 2013 |
Maintenance, reduction, or withdrawal of etanercept after treatment with etanercept and methotrexate in patients with moderate rheumatoid arthritis (PRESERVE): a randomised controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Five-year outcomes of probable rheumatoid arthritis treated with methotrexate or placebo during the first year (the PROMPT study).
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prognosis; Radiography; Remission Induction; Treatment Outcome | 2014 |
Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Resistance; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Motor Activity; Piperidines; Pyrimidines; Pyrroles; Radiography; Treatment Outcome | 2013 |
Changing sulphasalazine to methotrexate does not improve the 2-year outcomes of the initial single DMARD treatment in early rheumatoid arthritis: subanalysis of the FIN-RACo trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine; Treatment Outcome | 2013 |
Tabalumab in rheumatoid arthritis patients with an inadequate response to methotrexate and naive to biologic therapy: a phase II, randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; B-Cell Activating Factor; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2013 |
Golimumab reduces disease activity of rheumatoid arthritis for 1 year and strongly inhibits radiographic progression in Japanese patients: partial but detailed results of the GO-FORTH and GO-MONO studies.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Radiography; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Double-Blind Method; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Patient Dropouts; Radiography; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2002 |
Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 2002 |
Methotrexate twice weekly vs once weekly in rheumatoid arthritis: a pilot double-blind, controlled study.
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Pain Measurement; Pilot Projects; Treatment Outcome | 2002 |
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease-Free Survival; Drug Therapy, Combination; Female; HLA-DR1 Antigen; Humans; Male; Methotrexate; Middle Aged; Pain; Sulfasalazine | 2002 |
The effects of disease-modifying anti-rheumatic drugs on the Health Assessment Questionnaire score. Lessons from the leflunomide clinical trials database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Follow-Up Studies; Health Status; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Placebos; Sulfasalazine; Surveys and Questionnaires; Time Factors | 2002 |
Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: a six-month, double-blind, randomized, dose-ranging study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Health Status; Hospitals, Community; Hospitals, University; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2002 |
[Clinical investigation of effects of bizhongxiao decoction (BZX) on rheumatoid arthritis on active phase].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Combinations; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Plants, Medicinal | 2000 |
A pilot randomized trial comparing CD34-selected versus unmanipulated hemopoietic stem cell transplantation for severe, refractory rheumatoid arthritis.
Topics: Antigens, CD34; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Dose-Response Relationship, Drug; Feasibility Studies; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents; Methotrexate; Pilot Projects; Recurrence; Retreatment; Rheumatoid Factor; Safety; Severity of Illness Index; Time Factors; Treatment Outcome | 2002 |
Rescue of combination therapy failures using infliximab, while maintaining the combination or monotherapy with methotrexate: results of an open trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2002 |
Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biological Availability; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Injections, Intravenous; Male; Methotrexate; Middle Aged; Tablets | 2002 |
Longitudinal measurement of methotrexate liver concentrations does not correlate with liver damage, clinical efficacy, or toxicity during a 3.5 year double blind study in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury, Chronic; Double-Blind Method; Female; Humans; Liver; Longitudinal Studies; Male; Methotrexate; Middle Aged; Treatment Outcome | 2002 |
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. A randomized, double-blind, placebo-controlled trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Arthritis, Rheumatoid; Diarrhea; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver Function Tests; Male; Methotrexate; Middle Aged; Placebos; Quality of Life; Surveys and Questionnaires; Treatment Outcome | 2002 |
Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study.
Topics: Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Collagen Type I; Collagen Type II; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Peptide Fragments; Prednisolone; Prospective Studies; Radiography; Sensitivity and Specificity; Sulfasalazine | 2002 |
Effects of disease modifying agents and dietary intervention on insulin resistance and dyslipidemia in inflammatory arthritis: a pilot study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Combined Modality Therapy; Diet Therapy; Female; Humans; Hyperlipidemias; Insulin Resistance; Male; Methotrexate; Middle Aged; Outpatients; Pilot Projects; Risk Factors; South Africa; Treatment Outcome | 2002 |
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Collagenases; Combined Modality Therapy; Enzyme Precursors; Fatigue; Female; Humans; Male; Matrix Metalloproteinase 1; Metalloendopeptidases; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Edema; Female; Humans; Injections, Intra-Articular; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Radiography; Synovitis; Treatment Outcome | 2003 |
Subcutaneous administration of polymerized-type I collagen for the treatment of patients with rheumatoid arthritis. An open-label pilot trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen; Drug Therapy, Combination; Female; Health Status; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Patient Satisfaction; Pepsin A; Pilot Projects; Povidone; Treatment Outcome | 2003 |
[Clinical observation on treatment of rheumatoid arthritis by combined therapy with methotrexate, sulfasalazine and Chinese herbal medicine].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Sulfasalazine | 2002 |
[Clinical observation on small doses Tripterygium wilfordii polyglycoside combined with methotrexate in treating rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Glycosides; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Tripterygium | 2001 |
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Pain; Pain Measurement; Placebos; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2003 |
Cyclosporin A monotherapy versus cyclosporin A and methotrexate combination therapy in patients with early rheumatoid arthritis: a double blind randomised placebo controlled trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome | 2003 |
[Analysis of efficacy and safety of multiple intravenous infusion of anti-tumor necrosis factor-alpha monoclonal antibody (Remicade) combined with methotrexate compared with sodium aurothiomalate and intramuscular depot methylprednisolone in rheumatoid ar
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Drug Therapy, Combination; Female; Gold Sodium Thiomalate; Humans; Infliximab; Infusions, Intravenous; Injections, Intramuscular; Male; Methotrexate; Methylprednisolone; Middle Aged | 2002 |
Antinuclear antibodies following infliximab treatment in patients with rheumatoid arthritis or spondylarthropathy.
Topics: Adult; Aged; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Drug Therapy, Combination; Female; Fluorescent Antibody Technique, Indirect; Humans; Infliximab; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing | 2003 |
Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Chemical and Drug Induced Liver Injury; Creatinine; Digestive System; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sex Factors; Treatment Outcome | 2003 |
Reumacon (CPH82) showed similar x-ray progression and clinical effects as methotrexate in a two year comparative study on patients with early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Double-Blind Method; Female; Glycosides; Humans; Joints; Lignans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2003 |
Etanercept added to background methotrexate therapy in patients with rheumatoid arthritis: continued observations.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2003 |
Effectiveness of a measurement feedback system on outcome in rheumatoid arthritis: a controlled clinical trial.
Topics: Acute Disease; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Knowledge of Results, Psychological; Male; Methotrexate; Middle Aged; Patient Care Planning; Prednisolone; Regression Analysis; Rheumatology; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2003 |
Radiographic progression in early rheumatoid arthritis: a 12-month randomized controlled study comparing the combination of cyclosporin and methotrexate with methotrexate alone.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Single-Blind Method; Treatment Outcome | 2003 |
Five-year followup of rheumatoid arthritis patients after early treatment with disease-modifying antirheumatic drugs versus treatment according to the pyramid approach in the first year.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Organogold Compounds; Prospective Studies; Radiography; Treatment Outcome | 2003 |
Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn's disease.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Arthritis, Rheumatoid; Biological Availability; Crohn Disease; Cross-Over Studies; Drug Combinations; Female; Folic Acid; Half-Life; Humans; Male; Methotrexate; Middle Aged | 2003 |
Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: a pilot study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Half-Life; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Pilot Projects; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
Long term structural effects of combination therapy in patients with early rheumatoid arthritis: five year follow up of a prospective double blind controlled study.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2003 |
Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Growth Inhibitors; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged | 2003 |
The use of homeopathic preparation Vozraston in the therapy of patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Humans; Immunosuppressive Agents; Materia Medica; Methotrexate; Pain; Treatment Outcome | 2003 |
The effect of ingestion of ferrous sulfate on the absorption of oral methotrexate in patients with rheumatoid arthritis.
Topics: Absorption; Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Biological Availability; Confidence Intervals; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Ferrous Compounds; Humans; Male; Methotrexate; Middle Aged; Probability; Reference Values; Severity of Illness Index; Treatment Outcome | 2003 |
The effect of low-dose methotrexate on bone mineral density in patients with early rheumatoid arthritis.
Topics: Absorptiometry, Photon; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Female; Humans; Methotrexate; Middle Aged; Premenopause; Sulfasalazine; Treatment Outcome | 2003 |
An open, randomized comparison study of cyclosporine A, cyclosporine A + methotrexate and cyclosporine A + hydroxychloroquine in the treatment of early severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cyclosporine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pain Measurement; Severity of Illness Index; Treatment Outcome | 2005 |
Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: a six-month, open-label study.
Topics: Administration, Oral; Arthritis, Rheumatoid; Creatinine; Drug Therapy, Combination; Female; Humans; Hyperglycemia; Immunosuppressive Agents; Kidney; Male; Methotrexate; Middle Aged; Tacrolimus; Treatment Outcome | 2003 |
[Radiologic progression of rheumatoid arthritis lesions treated with methotrexate].
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Treatment Outcome | 2003 |
Homocysteine in patients with rheumatoid arthritis in relation to inflammation and B-vitamin treatment.
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Female; Health Status; Homocysteine; Humans; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Vitamin B Complex | 2003 |
Infliximab treatment for rheumatoid arthritis, with dose titration based on the Disease Activity Score: dose adjustments are common but not always sufficient to assure sustained benefit.
Topics: Acute Disease; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Statistics, Nonparametric; Time Factors; Treatment Outcome | 2004 |
Infliximab in active early rheumatoid arthritis.
Topics: Acute Disease; Analysis of Variance; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Finger Joint; Foot Joints; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography | 2004 |
Impact of initial aggressive drug treatment with a combination of disease-modifying antirheumatic drugs on the development of work disability in early rheumatoid arthritis: a five-year randomized followup trial.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Early Diagnosis; Employment; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Insurance Benefits; Male; Methotrexate; Middle Aged; Pensions; Prednisolone; Sulfasalazine | 2004 |
Effect of repeated infliximab therapy on serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Down-Regulation; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Methotrexate; Middle Aged; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2004 |
Dose escalation of parenteral methotrexate in active rheumatoid arthritis that has been unresponsive to conventional doses of methotrexate: a randomized, controlled trial.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Health Status; Humans; Injections, Intramuscular; Joints; Male; Methotrexate; Middle Aged; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2004 |
How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial.
Topics: Adult; Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index; Treatment Outcome | 2004 |
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Treatment Outcome | 2004 |
Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Quality of Life; Radiography; Treatment Outcome | 2004 |
Comparison of ultrasonographic assessment of synovitis and joint vascularity with radiographic evaluation in a randomized, placebo-controlled study of infliximab therapy in early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Humans; Infliximab; Joints; Methotrexate; Synovitis; Treatment Outcome; Ultrasonography | 2004 |
A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Receptors, Interleukin-1; Recombinant Proteins; Severity of Illness Index; Sialoglycoproteins | 2004 |
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis.
Topics: Adult; Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Crotonates; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Hydroxybutyrates; Immunosuppressive Agents; Interferon-gamma; Interleukin-6; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Nitriles; Toluidines | 2004 |
Economic evaluation of folate supplementation during methotrexate treatment in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Health Care Costs; Hematinics; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Patient Dropouts; Rheumatology; Time Factors | 2004 |
A good response to early DMARD treatment of patients with rheumatoid arthritis in the first year predicts remission during follow up.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Organogold Compounds; Pain Measurement; Prognosis; Proportional Hazards Models; Recurrence; Remission Induction; Severity of Illness Index; Treatment Outcome | 2005 |
Markers for type II collagen breakdown predict the effect of disease-modifying treatment on long-term radiographic progression in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Collagen; Collagen Type I; Collagen Type II; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Peptides; Prednisolone; Radiography; Sulfasalazine | 2004 |
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled
Topics: Activities of Daily Living; Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Placebos; Quality of Life; Radiography; Recovery of Function; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sialoglycoproteins; Treatment Outcome | 2004 |
Filtration leukocytapheresis therapy in the treatment of rheumatoid arthritis patients resistant to or failed with methotrexate.
Topics: Adult; Antigens, CD1; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; CD11a Antigen; CD11b Antigen; CD18 Antigens; Female; Flow Cytometry; Humans; Leukapheresis; Leukocytes; Male; Methotrexate; Middle Aged; Treatment Outcome | 2004 |
Improvement of refractory rheumatoid arthritis after depletion of B cells.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; B-Lymphocytes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Pain Measurement; Prognosis; Prospective Studies; Risk Assessment; Rituximab; Treatment Outcome | 2004 |
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Bacterial Infections; Cyclophosphamide; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Rituximab | 2004 |
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Atorvastatin; Biomarkers; Blood Sedimentation; Blood Viscosity; C-Reactive Protein; Cardiovascular Diseases; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Methotrexate; Middle Aged; Pyrroles; Risk Factors; von Willebrand Factor | 2004 |
Rapid alleviation of signs and symptoms of rheumatoid arthritis with intravenous or subcutaneous administration of adalimumab in combination with methotrexate.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Placebos; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Interferon beta-1a; Interferon-beta; Male; Methotrexate; Middle Aged; Radiography; Synovial Membrane; Treatment Outcome | 2005 |
Successful treatment of rheumatoid arthritis is associated with a reduction in serum sE-selectin and thrombomodulin level.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; E-Selectin; Female; Health Status; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Sulfasalazine; Thrombomodulin; Treatment Outcome | 2004 |
Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Infliximab; Logistic Models; Male; Methotrexate; Prognosis; Radiography; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized, double-blind, placebo controlled trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Retreatment; Treatment Outcome | 2004 |
A randomised comparative study of the short term clinical and biological effects of intravenous pulse methylprednisolone and infliximab in patients with active rheumatoid arthritis despite methotrexate treatment.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Infliximab; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; Methylprednisolone; Middle Aged; Quality of Life; Severity of Illness Index; Single-Blind Method | 2004 |
Indirect and total costs of early rheumatoid arthritis: a randomized comparison of combined step-down prednisolone, methotrexate, and sulfasalazine with sulfasalazine alone.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Early Diagnosis; Female; Health Care Costs; Health Expenditures; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Sensitivity and Specificity; Sulfasalazine | 2004 |
Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Over Studies; Cyclooxygenase 2; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Male; Membrane Proteins; Methotrexate; Middle Aged; Organic Chemicals; Prostaglandin-Endoperoxide Synthases | 2004 |
A comparative study of etanercept plus methotrexate and methotrexate alone in Taiwanese patients with active rheumatoid arthritis: a 12-week, double-blind, randomized, placebo-controlled study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2004 |
Adalimumab in rheumatoid arthritis.
Topics: Adalimumab; Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Pain Measurement; Reference Values; Severity of Illness Index; Treatment Outcome | 2004 |
Infliximab in rheumatoid arthritis.
Topics: Administration, Oral; Antibodies, Monoclonal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Injections, Subcutaneous; International Cooperation; Male; Methotrexate; Pain Measurement; Severity of Illness Index; Treatment Outcome | 2004 |
Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2004 |
Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Decision Making; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Guideline Adherence; Humans; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Survival Analysis; Treatment Outcome | 2004 |
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
The immunosuppressive effect of methotrexate in active rheumatoid arthritis patients vs. its stimulatory effect in nonactive patients, as indicated by cytometric measurements of CD4+ T cell subpopulations.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; CD28 Antigens; CD4-Positive T-Lymphocytes; Flow Cytometry; Fluorescence Polarization; Humans; Immunosuppression Therapy; Methotrexate; Middle Aged | 2004 |
Unaltered etanercept pharmacokinetics with concurrent methotrexate in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Availability; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Receptors, Tumor Necrosis Factor; Reproducibility of Results | 2004 |
Genetic risk factors for infection in patients with early rheumatoid arthritis.
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Etanercept; Female; Genetic Predisposition to Disease; Genotype; Humans; Immunoglobulin G; Lymphotoxin-alpha; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, IgG; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha; Urinary Tract Infections | 2004 |
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial.
Topics: Adult; Antibodies; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Autoimmunity; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Patient Dropouts; Recovery of Function; Treatment Outcome | 2004 |
[Effect of small-dose glucocorticoids on the course of early rheumatic arthritis].
Topics: Adolescent; Adult; Age Factors; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisone; Sex Factors; Time Factors; Treatment Outcome | 2004 |
B lymphocyte depletion in rheumatoid arthritis: targeting of CD20.
Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Arthritis, Rheumatoid; B-Lymphocytes; Combined Modality Therapy; Cyclophosphamide; Humans; Lymphocyte Depletion; Methotrexate; Models, Immunological; Rheumatoid Factor; Rituximab | 2005 |
Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: five-year experience from the FIN-RACo trial.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisolone; Remission Induction; Sick Leave; Sulfasalazine; Time Factors; Work Capacity Evaluation | 2005 |
Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Data Interpretation, Statistical; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Reproducibility of Results | 2005 |
Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-m
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Infliximab; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Prognosis; Quality of Life; Remission Induction; Severity of Illness Index; Synovitis | 2005 |
Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Etanercept; Health Care Costs; Health Resources; Humans; Immunoglobulin G; Markov Chains; Methotrexate; Middle Aged; Models, Econometric; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sick Leave; Sweden; Tumor Necrosis Factor-alpha | 2005 |
Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroscopy; Chemokine CXCL12; Chemokines, CXC; Drug Therapy, Combination; Female; Humans; Immunoenzyme Techniques; Infliximab; Interleukin-18; Ligands; Male; Methotrexate; Middle Aged; Synovial Membrane; Synovitis; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Magnetic resonance imaging for accelerated assessment of drug effect and prediction of subsequent radiographic progression in rheumatoid arthritis: a study of patients receiving combined anakinra and methotrexate treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Hand; Humans; Interleukin 1 Receptor Antagonist Protein; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Prognosis; Radiography; Receptors, Interleukin-1; Sialoglycoproteins; Synovitis; Treatment Outcome; Wrist Joint | 2005 |
Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomi
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Health Status; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Retreatment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
Effectiveness of systematic monitoring of rheumatoid arthritis disease activity in daily practice: a multicentre, cluster randomised controlled trial.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Patient Compliance; Prednisone; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2005 |
Comparison of different definitions to classify remission and sustained remission: 1 year TEMPO results.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pain Measurement; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome | 2005 |
Early and late effect of infliximab on circulating dendritic cells phenotype in rheumatoid arthritis patients.
Topics: Adult; Antibodies, Monoclonal; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; CD11c Antigen; CD83 Antigen; Dendritic Cells; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Immunoglobulins; Infliximab; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; Phenotype; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
A 48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination methotrexate and intramuscular gold therapy in rheumatoid arthritis: results of the METGO study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Gold; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Time Factors | 2005 |
Impact of managed care on the use of biologic agents for rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; California; Cyclooxygenase Inhibitors; Fee-for-Service Plans; Female; Health Maintenance Organizations; Humans; Interviews as Topic; Male; Managed Care Programs; Methotrexate; Middle Aged | 2005 |
Population pharmacokinetics of rituximab (anti-CD20 monoclonal antibody) in rheumatoid arthritis patients during a phase II clinical trial.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Body Surface Area; Cyclophosphamide; Female; Humans; Immunologic Factors; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Rituximab; Sex Factors | 2005 |
Longterm safety, efficacy, and radiographic outcome with etanercept treatment in patients with early rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2005 |
[Comparative study on clinical efficacy of using methotrexate singly or combined with total glucosides of Paeony in treating rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucosides; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Paeonia; Phytotherapy | 2005 |
Patient reported outcomes in a trial of combination therapy with etanercept and methotrexate for rheumatoid arthritis: the TEMPO trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Health Status Indicators; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Patient Satisfaction; Quality of Life; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2006 |
Methotrexate dosage reduction in patients with rheumatoid arthritis beginning therapy with infliximab: the Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pain Measurement | 2005 |
Reduction of temporomandibular joint pain after treatment with a combination of methotrexate and infliximab is associated with changes in synovial fluid and plasma cytokines in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pain; Prospective Studies; Synovial Fluid; Temporomandibular Joint Disorders | 2005 |
An open label, single dose study to evaluate the safety, efficacy, and effects on CD25 expression of ciclosporin in patients with active rheumatoid arthritis despite treatment with methotrexate and infliximab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Infliximab; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Pilot Projects; Receptors, Interleukin-2; Severity of Illness Index; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Coadministration of lansoprazole and naproxen does not affect the pharmacokinetic profile of methotrexate in adult patients with rheumatoid arthritis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Dizziness; Dose-Response Relationship, Drug; Female; Headache; Humans; Lansoprazole; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Nausea; Omeprazole; Vomiting | 2005 |
Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Hematinics; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Treatment Outcome | 2005 |
Modification of pro- and antiinflammatory cytokines and vascular-related molecules by tumor necrosis factor-a blockade in patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Interleukin-10; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Remission Induction; Treatment Outcome; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2005 |
The incidence of Proteus mirabilis infection increases in patients on treatment but does not trigger disease activity.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Bacterial; Antibody Specificity; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Follow-Up Studies; Humans; Hydroxychloroquine; Immunoglobulins; Male; Methotrexate; Middle Aged; Proteus Infections; Proteus mirabilis; Remission Induction; Serologic Tests; Steroids | 2006 |
[Correlations of clinical symptoms and treatment efficacy in patients with rheumatoid arthritis treated with Chinese herbal drugs or Western medicine].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis, Rheumatoid; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Regression Analysis; Sulfasalazine; Treatment Outcome; Tripterygium | 2005 |
Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study.
Topics: Adalimumab; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Time Factors | 2006 |
A phase 2 dose-finding study of PEGylated recombinant methionyl human soluble tumor necrosis factor type I in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Health Status; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Quality of Life; Receptors, Tumor Necrosis Factor, Type I; Recombinant Proteins; Treatment Outcome | 2005 |
Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study.
Topics: Adalimumab; Adult; Aged; Aged, 80 and over; Antibodies, Anticardiolipin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Reproducibility of Results; Rheumatoid Factor | 2006 |
Disease activity and functional changes of RA patients receiving different DMARDs in clinical practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Recovery of Function; Severity of Illness Index | 2006 |
The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previo
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2006 |
Ultrasonographic and radiographic results from a two-year controlled trial of immediate or one-year-delayed addition of infliximab to ongoing methotrexate therapy in patients with erosive early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Radiography; Time Factors; Ultrasonography | 2006 |
[A clinical trial of low dose methotrexate therapy in patients with rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 2005 |
A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Severity of Illness Index; Treatment Outcome | 2006 |
[Analysis on symptomatic factors of rheumatoid arthritis and its correlation with therapeutic efficacy].
Topics: Adult; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Drugs, Chinese Herbal; Factor Analysis, Statistical; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Phytotherapy; Sulfasalazine | 2005 |
Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone.
Topics: Adult; Aged; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Doxycycline; Drug Therapy, Combination; Enzyme Inhibitors; Female; Health Status; Humans; Male; Metalloproteases; Methotrexate; Middle Aged; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2006 |
Effect of anti-tumor necrosis factor alpha therapy on the progression of subclinical atherosclerosis in severe rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Carotid Artery Diseases; Disease Progression; Drug Resistance; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE study.
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Safety and efficacy of etanercept treatment in elderly subjects with rheumatoid arthritis.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Severity of Illness Index; Treatment Outcome | 2006 |
Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure.
Topics: Acute-Phase Reaction; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Medical Records; Methotrexate; Middle Aged; Proportional Hazards Models; Retreatment; Survival Analysis; Treatment Failure; Treatment Outcome | 2006 |
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Disease Progression; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Radiography | 2006 |
Infliximab treatment maintains employability in patients with early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Employment; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged | 2006 |
[Long-term therapy with the selective costimulation modulator CTLA4lg in rheumatoid arthritis].
Topics: Abatacept; Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Humans; Immunoconjugates; Long-Term Care; Methotrexate; Quality of Life; Randomized Controlled Trials as Topic | 2006 |
Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infections; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Neoplasms; Receptors, Tumor Necrosis Factor; Risk; Risk Assessment; Time Factors; Treatment Outcome | 2006 |
Treatment of rheumatoid arthritis patients with abatacept and methotrexate significantly improved health-related quality of life.
Topics: Abatacept; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Immunoconjugates; International Cooperation; Male; Methotrexate; Middle Aged; Quality of Life; Severity of Illness Index; Sickness Impact Profile; Treatment Outcome | 2006 |
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Time Factors | 2006 |
The safety of infliximab, combined with background treatments, among patients with rheumatoid arthritis and various comorbidities: a large, randomized, placebo-controlled trial.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infections; Infliximab; Male; Methotrexate; Middle Aged; Risk Assessment; Severity of Illness Index | 2006 |
Effect of etanercept on fatigue in patients with recent or established rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Etanercept; Fatigue; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Time Factors | 2006 |
A phase I study assessing the safety, clinical response, and pharmacokinetics of an experimental infliximab formulation for subcutaneous or intramuscular administration in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Humans; Infliximab; Injections, Intramuscular; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Pilot Projects | 2006 |
Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, par
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Betamethasone; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Male; Methotrexate; Middle Aged | 2006 |
The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Rituximab; Safety | 2006 |
Controlled trial of methotrexate versus CH-1504 in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aminopterin; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Gastrointestinal Tract; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged | 2006 |
Adalimumab and methotrexate is more effective than adalimumab alone in patients with established rheumatoid arthritis: results from a 6-month longitudinal, observational, multicentre study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Leflunomide and methotrexate combination therapy in daily clinical practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Isoxazoles; Leflunomide; Methotrexate | 2006 |
[The influence of IL-6 polymorphism on efficacy of treatment of rheumatoid arthritis patients with methotrexate and prednisone].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Genotype; Glucocorticoids; Humans; Interleukin-6; Joints; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prednisone; Promoter Regions, Genetic; Severity of Illness Index | 2005 |
Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial.
Topics: Abatacept; Adult; Aged; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Resistance; Female; Humans; Immunoconjugates; Infections; Male; Methotrexate; Middle Aged; Quality of Life; Radiography; Treatment Outcome | 2006 |
Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Central Nervous System Stimulants; Cohort Studies; Diet; Drug Interactions; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Surveys and Questionnaires | 2006 |
Bone metabolism changes during anti-TNF-alpha therapy in patients with active rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Bone Density; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Prednisone; Tumor Necrosis Factor-alpha | 2006 |
Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis.
Topics: Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Treatment Outcome | 2006 |
Rapid improvement in rheumatoid arthritis patients on combination of methotrexate and infliximab: clinical and magnetic resonance imaging evaluation.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Image Processing, Computer-Assisted; Infliximab; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Pilot Projects; Severity of Illness Index; Synovitis; Wrist Joint | 2007 |
Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arachidonic Acid; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Dinoprostone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eicosanoids; Female; Fish Oils; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Risk Factors; Sulfasalazine; Thromboxane A2 | 2006 |
[Therapeutic effect and impact on cytokine production by methotrexate in rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Cytokines; Female; Humans; Immunosuppressive Agents; Interleukin-10; Interleukin-1beta; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study.
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Cohort Studies; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Prospective Studies; Ribonucleosides; Treatment Outcome | 2006 |
Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Scotland; Sulfasalazine; Treatment Outcome | 2007 |
Early rheumatoid arthritis: combination therapy with disease-modifying antirheumatic drugs and low-dose glucocorticoids?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Glucocorticoids; Humans; Methotrexate; Middle Aged; Prednisolone; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome | 2006 |
Early rheumatoid arthritis: combination therapy of doxycycline plus methotrexate versus methotrexate monotherapy.
Topics: Adult; Aged; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Doxycycline; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Treatment Outcome | 2006 |
The effect of 3435C>T MDR1 gene polymorphism on rheumatoid arthritis treatment with disease-modifying antirheumatic drugs.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Therapy, Combination; Female; Genetic Testing; Heterozygote; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Sulfasalazine | 2006 |
Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Europe; Female; Humans; Male; Methotrexate; Middle Aged; Pain; Patient Selection; Receptors, Interleukin-6; Safety; Treatment Failure; Treatment Outcome | 2006 |
Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis.
Topics: Adenosine; Adult; Aged; AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Female; Gene Expression Regulation, Enzymologic; Genetic Variation; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Single-Blind Method | 2006 |
Plasma level of CXC-chemokine CXCL12 is increased in rheumatoid arthritis and is independent of disease activity and methotrexate treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Chemokine CXCL12; Chemokines, CXC; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prognosis; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic | 2006 |
Abatacept improves both the physical and mental health of patients with rheumatoid arthritis who have inadequate response to methotrexate treatment.
Topics: Abatacept; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Fatigue; Female; Humans; Immunoconjugates; Longitudinal Studies; Male; Methotrexate; Middle Aged; Quality of Life; Sickness Impact Profile | 2007 |
Sustained benefit in rheumatoid arthritis following one course of rituximab: improvements in physical function over 2 years.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pain Measurement; Recovery of Function; Rituximab; Severity of Illness Index; Treatment Outcome | 2006 |
Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Cell Activating Factor; B-Lymphocytes; Cyclophosphamide; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Rituximab; Tumor Necrosis Factor Ligand Superfamily Member 13 | 2006 |
Evaluation of a modified ACR20 scoring system in patients with rheumatoid arthritis receiving treatment with etanercept.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dose-Response Relationship, Drug; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2006 |
Impact of concomitant DMARD therapy on adherence to treatment with etanercept and infliximab in rheumatoid arthritis. Results from a six-year observational study in southern Sweden.
Topics: Age Factors; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Patient Compliance; Receptors, Tumor Necrosis Factor; Regression Analysis; Sweden | 2006 |
Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis.
Topics: Adipose Tissue; Antirheumatic Agents; Arthritis, Rheumatoid; Body Composition; Cachexia; Etanercept; Female; Humans; Immunoglobulin G; Immunologic Factors; Insulin-Like Growth Factor I; Male; Methotrexate; Middle Aged; Muscle, Skeletal; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha; Weight Gain | 2006 |
Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies; Cysteine; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Pain; Prednisolone; Prospective Studies; Remission Induction; Severity of Illness Index; Sulfasalazine | 2006 |
[Predictive role of diagnostic information in treatment efficacy of rheumatoid arthritis based on neural network model analysis].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drugs, Chinese Herbal; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Neural Networks, Computer; Phytotherapy; Sulfasalazine; Treatment Outcome | 2007 |
Preliminary evaluation in rheumatoid arthritis activity in patients treated with TNF-alpha blocker plus methotrexate versus methotrexate or leflunomide alone.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pilot Projects; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; gamma-Glutamyl Hydrolase; Gene Frequency; Humans; Methotrexate; Peptide Synthases; Polymorphism, Single Nucleotide; Single-Blind Method | 2007 |
Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Sulfasalazine; Treatment Failure; Treatment Outcome | 2007 |
Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid Antagonists; Gene Frequency; Genotype; Humans; Male; Membrane Transport Proteins; Methotrexate; Methylprednisolone; Middle Aged; Odds Ratio; Patient Selection; Phenotype; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Transaminases; Treatment Outcome | 2007 |
Levofloxacin treatment in patients with rheumatoid arthritis receiving methotrexate.
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Levofloxacin; Male; Methotrexate; Middle Aged; Ofloxacin; Quality of Life; Range of Motion, Articular; Severity of Illness Index; Treatment Outcome | 2007 |
Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug use.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fish Oils; Glucocorticoids; Humans; Hydroxychloroquine; Longitudinal Studies; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2007 |
Eight versus 16-week re-evaluation period in rheumatoid arthritis patients treated with leflunomide or methotrexate accompanied by moderate dose prednisone.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intramuscular; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2007 |
A relationship between pharmacokinetics (PK) and the efficacy of infliximab for patients with rheumatoid arthritis: characterization of infliximab-resistant cases and PK-based modified therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Female; Humans; Infliximab; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Treatment Outcome | 2007 |
Influence of methotrexate dose on its efficacy and safety in rheumatoid arthritis patients: evidence based on the variety of prescribing approaches among practicing Japanese rheumatologists in a single institute-based large observational cohort (IORRA).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Female; Humans; Japan; Longitudinal Studies; Male; Methotrexate; Prednisolone; Safety | 2007 |
Response to pneumococcal vaccine in patients with early rheumatoid arthritis receiving infliximab plus methotrexate or methotrexate alone.
Topics: Adult; Antibodies, Monoclonal; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines | 2007 |
Short-term effects of the TNFalpha antagonist infliximab on the acute phase reaction and activities of daily life in patients with rheumatoid arthritis.
Topics: Activities of Daily Living; Acute-Phase Reaction; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Female; Fibrinogen; Humans; Infliximab; Male; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cross-Sectional Studies; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2007 |
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.
Topics: Adult; Aged; Analysis of Variance; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Disease Progression; Double-Blind Method; Female; Foot Joints; Hand Joints; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Treatment Outcome | 2007 |
Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Disease Progression; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Computer-Assisted; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Treatment Outcome | 2007 |
Changes in biomarkers of inflammation and bone turnover and associations with clinical efficacy following infliximab plus methotrexate therapy in patients with early rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Remodeling; Drug Therapy, Combination; Female; Humans; Inflammation Mediators; Infliximab; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2007 |
A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab.
Topics: Absorptiometry, Photon; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Bone Density; Case-Control Studies; Drug Resistance; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Osteocalcin; Parathyroid Hormone | 2007 |
Infliximab and methotrexate as induction therapy in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Administration Schedule; Follow-Up Studies; Health Status; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Middle Aged; Patient Selection; Radiography; Surveys and Questionnaires; Treatment Failure; Treatment Outcome | 2007 |
Reliability and sensitivity to change of the Simple Erosion Narrowing Score compared with the Sharp-van der Heijde method for scoring radiographs in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Observer Variation; Radiography; Receptors, Tumor Necrosis Factor; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome | 2008 |
Patient-reported health outcomes in a trial of etanercept monotherapy versus combination therapy with etanercept and methotrexate for rheumatoid arthritis: the ADORE trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Combined Modality Therapy; Etanercept; Follow-Up Studies; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Pain; Pain Measurement; Patient Satisfaction; Prospective Studies; Quality of Life; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2008 |
A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Genotype; Haplotypes; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Higher maximal serum concentration of methotrexate predicts the incidence of adverse reactions in Japanese rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; ROC Curve | 2007 |
Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Down-Regulation; Female; Gene Expression Regulation; Humans; Male; Methotrexate; Middle Aged; NF-kappa B p50 Subunit; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Tumor Necrosis Factor-alpha; Up-Regulation | 2007 |
[Effect of strengthening Pi and activating blood circulation therapy on serum levels of adrenocorticotrophic hormone and vascular endothelial growth factor in rheumatoid arthritis patients].
Topics: Adrenocorticotropic Hormone; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Indomethacin; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Phytotherapy; Vascular Endothelial Growth Factor A; Young Adult | 2007 |
The safety and efficacy of adding etanercept to methotrexate or methotrexate to etanercept in moderately active rheumatoid arthritis patients previously treated with monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2008 |
A controlled study of double filtration plasmapheresis in the treatment of active rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Plasmapheresis; Quality of Life; Recovery of Function; Sulfasalazine; Treatment Outcome | 2007 |
Rituximab pharmacokinetics in patients with rheumatoid arthritis: B-cell levels do not correlate with clinical response.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Cyclophosphamide; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome | 2007 |
Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Foot Joints; Glucocorticoids; Hand Joints; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Prednisolone; Quality of Life; Radiography; Treatment Outcome | 2008 |
[Leflunomide as a second choice treatment in patients with rheumatoid arthritis].
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2007 |
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
Topics: Aged; alpha-Macroglobulins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Down-Regulation; Enzyme Inhibitors; Female; Humans; Isoxazoles; Leflunomide; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Multiprotein Complexes; Phenylalanine; Statistics, Nonparametric; Thiophenes | 2008 |
Aggressive combination therapy with intra-articular glucocorticoid injections and conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis: second-year clinical and radiographic results from the CIMESTRA study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Betamethasone; Combined Modality Therapy; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2008 |
Anti-tumor necrosis factor-alpha therapy in the ordinary clinical setting: Three-year effectiveness in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Health Status; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Association of anemia and physical disability among patients with rheumatoid arthritis.
Topics: Adult; Aged; Anemia; Antibodies, Monoclonal; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Female; Hemoglobins; Humans; Infliximab; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Tumor Necrosis Factor-alpha | 2007 |
[Clinical observation on effect of total glucosides of paeony combined with methotrexate on rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucosides; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Paeonia; Phytotherapy; Treatment Outcome; Young Adult | 2007 |
677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Gene Frequency; Genotype; Humans; Logistic Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Methylprednisolone; Middle Aged; Polymorphism, Restriction Fragment Length; Treatment Outcome | 2007 |
Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study.
Topics: Adult; Arthritis, Rheumatoid; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Everolimus; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Placebos; Severity of Illness Index; Sirolimus; Statistics, Nonparametric; Treatment Outcome | 2008 |
Daily practice effectiveness of a step-down treatment in comparison with a tight step-up for early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Health Status; Humans; Infant; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies; Rheumatology; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2008 |
Responsiveness to anti-tumour necrosis factor alpha therapy is related to pre-treatment tissue inflammation levels in rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Binding Sites; Biopsy; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Expression Profiling; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index; Synovial Membrane; Synovitis; Transcription Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Edema; Female; Humans; Infliximab; Infusions, Intravenous; Joints; Magnetic Resonance Imaging; Male; Methotrexate; Methylprednisolone; Middle Aged; Pulse Therapy, Drug; Synovitis; Treatment Outcome | 2007 |
Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Longitudinal Studies; Male; Methotrexate; Multivariate Analysis; Radiography; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome | 2007 |
Delay in imaging versus clinical response: a rationale for prolonged treatment with anti-tumor necrosis factor medication in early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Pilot Projects; Prospective Studies; Quality of Life; Remission Induction; Synovitis; Time Factors; Tumor Necrosis Factor-alpha; Ultrasonography | 2007 |
Improved health-related quality of life for patients with active rheumatoid arthritis receiving rituximab: Results of the Dose-Ranging Assessment: International Clinical Evaluation of Rituximab in Rheumatoid Arthritis (DANCER) Trial.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Satisfaction; Quality of Life; Rituximab; Severity of Illness Index; Treatment Outcome | 2008 |
Requirement of methotrexate in combination with anti-tumor necrosis factor-alpha therapy for adequate suppression of osteoclastogenesis in rheumatoid arthritis.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Interleukin-6; Methotrexate; Mice; Mice, SCID; Osteoclasts; Tumor Necrosis Factor-alpha | 2007 |
Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate.
Topics: Abatacept; Adult; Analysis of Variance; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Drug Administration Schedule; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Placebos; Quality of Life; Safety; Treatment Failure; Treatment Outcome | 2008 |
Adalimumab plus methotrexate improved SF-36 scores and reduced the effect of rheumatoid arthritis (RA) on work activity for patients with early RA.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Employment; Female; Humans; Male; Methotrexate; Middle Aged; Patient Satisfaction; Quality of Life; Severity of Illness Index; Tumor Necrosis Factor-alpha; United States | 2008 |
Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2008 |
Correlations between symptoms as assessed in traditional chinese medicine (TCM) and ACR20 efficacy response: a comparison study in 396 patients with rheumatoid arthritis treated with TCM or Western medicine.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Single-Blind Method; Sulfasalazine; Treatment Outcome | 2007 |
[Comparative study on characteristics of Chinese and Western medicine for treatment of rheumatoid arthritis regarding cartilage erosion related blood biochemical and immunological factors].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Drugs, Chinese Herbal; Erythrocyte Count; Female; Humans; Male; Methotrexate; Middle Aged; Phytotherapy; Platelet Count; Prednisone; Young Adult | 2007 |
Level of radiographic damage and radiographic progression are determinants of physical function: a longitudinal analysis of the TEMPO trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Foot Joints; Hand Joints; Humans; Immunoglobulin G; Male; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor | 2008 |
Does the use of tumour necrosis factor antagonist therapy in poor prognosis, undifferentiated arthritis prevent progression to rheumatoid arthritis?
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Disease Progression; Female; Follow-Up Studies; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Pilot Projects; Prognosis; Remission Induction; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2008 |
Histological analysis of synovium in cases of effect attenuation associated with infliximab therapy in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Bromodeoxyuridine; Female; Humans; Immunohistochemistry; Infliximab; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; NF-kappa B; Synovial Membrane; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2008 |
Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis.
Topics: Adiponectin; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Body Composition; Bone Density; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Methotrexate; Middle Aged; Steroids; Tumor Necrosis Factor-alpha | 2008 |
Predictors of response to anti-TNF therapy according to ACR and EULAR criteria in patients with established RA: results from the South Swedish Arthritis Treatment Group Register.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Prognosis; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Sex Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Cost-effectiveness of abatacept in patients with moderately to severely active rheumatoid arthritis and inadequate response to methotrexate.
Topics: Abatacept; Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disability Evaluation; Disease Progression; Drug Costs; Female; Health Care Costs; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Models, Econometric; Quality-Adjusted Life Years; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Health Status; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Quality of Life; Radiography; Severity of Illness Index; Treatment Outcome | 2008 |
Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate: a randomized, double-blind, placebo-controlled, dose-ranging study.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2008 |
Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Rituximab; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Frequency and duration of clinical remission in patients with peripheral psoriatic arthritis requiring second-line drugs.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Administration Schedule; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; C-Reactive Protein; Drug Therapy, Combination; Female; Femur Neck; Glucocorticoids; Humans; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Osteoporosis; Prednisone; Prospective Studies; Severity of Illness Index; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Progression of joint damage in early rheumatoid arthritis: association with HLA-DRB1, rheumatoid factor, and anti-citrullinated protein antibodies in relation to different treatment strategies.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Disease Progression; Female; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Infliximab; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Rheumatoid Factor; Sulfasalazine | 2008 |
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Denosumab; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; RANK Ligand; Time Factors | 2008 |
Triple therapy in early active rheumatoid arthritis: a randomized, single-blind, controlled trial comparing step-up and parallel treatment strategies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Single-Blind Method; Sulfasalazine | 2008 |
Efficacy of low-dose tacrolimus added to methotrexate in patients with rheumatoid arthritis in Japan: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2008 |
Leflunomide (Arava) is a useful DMARD in Indian (Asian) patients: a clinic-based observational study of 1-year treatment.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Prospective Studies; Treatment Outcome | 2008 |
Treatment impact on estimated medical expenditure and job loss likelihood in rheumatoid arthritis: re-examining quality of life outcomes from a randomized placebo-controlled clinical trial with abatacept.
Topics: Abatacept; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Health Care Costs; Health Status Indicators; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Psychometrics; Quality of Life; Treatment Failure; Tumor Necrosis Factor-alpha; Unemployment; United States | 2008 |
Decreased external home help use with improved clinical status in rheumatoid arthritis: an exploratory analysis of the Abatacept in Inadequate responders to Methotrexate (AIM) trial.
Topics: Abatacept; Arthritis, Rheumatoid; Double-Blind Method; Female; Follow-Up Studies; Home Care Services; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Satisfaction; Quality of Life; Surveys and Questionnaires | 2008 |
Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 1983 |
A controlled two-centre trial of parenteral methotrexate therapy for refractory rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Nausea | 1984 |
[Methotrexate and salazosulfapyridine in the long-term treatment of rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine | 1995 |
Lymphocyte phenotype studies of rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Female; HLA-DR Antigens; Humans; Immunophenotyping; Immunosuppressive Agents; Lymphocyte Count; Lymphocyte Subsets; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Receptors, Interleukin-2; Treatment Outcome | 1994 |
Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD4 Antigens; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; Recombinant Fusion Proteins | 1995 |
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cytokines; Drug Combinations; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Osmolar Concentration; Sulfasalazine | 1995 |
Serum soluble interleukin-2 receptor levels in rheumatoid arthritis: effect of methotrexate, sulphasalazine and hydroxychloroquine therapy.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Receptors, Interleukin-2; Severity of Illness Index; Sulfasalazine | 1995 |
Circulating interleukin 10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report.
Topics: Adult; Aged; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Female; Gold; Humans; Injections, Intramuscular; Interleukin-10; Interleukin-6; Male; Methotrexate; Middle Aged | 1995 |
Infections during low-dose methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prospective Studies; Psoriasis | 1995 |
Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis. Results of two phase II studies. The CD5 Plus Rheumatoid Arthritis Investigators Group.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, CD; Arthritis, Rheumatoid; Azathioprine; CD5 Antigens; Cell Count; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Immunotoxins; Male; Methotrexate; Middle Aged; Prospective Studies; Ricin; T-Lymphocytes; Treatment Outcome | 1993 |
Low-dose methotrexate may cause air trapping in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Neutrophils; Prospective Studies; Pulmonary Gas Exchange; Residual Volume; Respiratory Function Tests | 1995 |
Antiperinuclear factor and disease activity in rheumatoid arthritis. Longitudinal evaluation during methotrexate and azathioprine therapy.
Topics: Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged | 1994 |
Endpoint measures in rheumatoid arthritis clinical trials: group summary and individual patient analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Disability Evaluation; Disease Progression; Female; Gold; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Penicillamine; Prospective Studies; Surveys and Questionnaires; Treatment Outcome | 1994 |
Effects of low dose methotrexate therapy on the concentration and the glycosylation of alpha 1-acid glycoprotein in the serum of patients with rheumatoid arthritis: a longitudinal study.
Topics: alpha 1-Antitrypsin; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Glycosylation; Haptoglobins; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Orosomucoid | 1994 |
Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Creatine; Female; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Time Factors | 1995 |
Examination of pharmacokinetic variables in a cohort of patients with rheumatoid arthritis beginning therapy with methotrexate compared with a cohort receiving the drug for a mean of 81 months.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies; Creatinine; Female; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Prednisone; Time Factors | 1995 |
The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. Rheumatoid Arthritis Clinical Trial Archive Group.
Topics: Aged; Aging; Arthritis, Rheumatoid; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Methotrexate; Middle Aged; Odds Ratio | 1995 |
Interleukin 6 (IL-6) and soluble IL-2 receptor levels in patients with rheumatoid arthritis treated with low dose oral methotrexate.
Topics: Administration, Oral; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Interleukin-6; Methotrexate; Middle Aged; Receptors, Interleukin-2; Solubility | 1995 |
Every-other-week methotrexate in patients with rheumatoid arthritis. A double-blind, placebo-controlled prospective study.
Topics: Aged; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome | 1995 |
[Low-dose methotrexate therapy of rheumatoid arthritis in the elderly].
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Gold; Humans; Male; Methotrexate; Prednisolone | 1995 |
Combination therapy with cyclosporine and methotrexate in severe rheumatoid arthritis. The Methotrexate-Cyclosporine Combination Study Group.
Topics: Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 1995 |
[Comparison of azathioprine and methotrexate in rheumatoid arthritis: an open-randomized clinical study].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Immunoglobulin M; Male; Methotrexate; Middle Aged; Rheumatoid Factor | 1994 |
Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies).
Topics: Adult; Arthritis, Rheumatoid; Blood Pressure; Blood Urea Nitrogen; Creatinine; Cyclosporine; Drug Therapy, Combination; Female; Gold; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Pilot Projects | 1994 |
Methotrexate and sulphasalazine as combination therapy in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine; Time Factors | 1994 |
Tolerability of methotrexate starting with 15 or 25 mg/week for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Chi-Square Distribution; Cohort Studies; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Humans; Liver; Male; Methotrexate; Middle Aged; Prospective Studies | 1994 |
Methotrexate in rheumatoid arthritis. A five-year prospective multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Severity of Illness Index; Treatment Outcome | 1994 |
Osteocalcin in patients with rheumatoid arthritis. A one-year followup study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Double-Blind Method; Female; Follow-Up Studies; Gold Sodium Thiomalate; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Osteocalcin; Prospective Studies | 1994 |
Combination therapy with methotrexate and chloroquine in rheumatoid arthritis. A multicenter randomized placebo-controlled trial.
Topics: Adult; Arthritis, Rheumatoid; Chloroquine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 1994 |
Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Diet; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Treatment Outcome; Vitamin B 12 | 1994 |
Combination of methotrexate and sulphasalazine vs methotrexate alone: a randomized open clinical trial in rheumatoid arthritis patients resistant to sulphasalazine therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 1994 |
Methotrexate concentrations in synovial membrane and trabecular and cortical bone in rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone and Bones; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Synovial Membrane | 1994 |
Use of cyclosporine in the treatment of autoimmune disorders.
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Cyclosporine; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Male; Methotrexate; Myelodysplastic Syndromes; Recurrence | 1994 |
[A comparative evaluation of the treatment results with cyclosporin A, methotrexate and azathioprine in rheumatoid arthritis patients (a preliminary report)].
Topics: Arthritis, Rheumatoid; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Remission Induction; Time Factors | 1993 |
Cyclosporine-induced alterations in renal function are not associated with lipid peroxidation.
Topics: Arthritis, Rheumatoid; Creatinine; Cyclosporine; Double-Blind Method; Female; Humans; Kidney; Lipid Peroxidation; Male; Methotrexate; Middle Aged | 1994 |
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Fluorescence Polarization Immunoassay; Flurbiprofen; Humans; Ketoprofen; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Piroxicam | 1994 |
Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; C-Reactive Protein; Disabled Persons; Hemoglobins; Humans; Hydroxychloroquine; Joints; Methotrexate; Pain; Reproducibility of Results; Severity of Illness Index; Sulfasalazine | 1993 |
Bronchoalveolar lavage and lung biopsy in rheumatoid arthritis. In vivo effects of disease modifying antirheumatic drugs.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Bronchoalveolar Lavage Fluid; Chloroquine; Humans; Lung; Lymphocyte Subsets; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine | 1993 |
The role of helplessness in the response to disease modifying drugs in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Behavior; Cognition; Disability Evaluation; Female; Gold; Helplessness, Learned; Humans; Joints; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Pain; Self Disclosure; Severity of Illness Index; Sulfasalazine; Time Factors | 1993 |
The effect of methylprednisolone pulse therapy on methotrexate treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Severity of Illness Index; Treatment Outcome | 1993 |
Interleukin-2 receptor levels in the sera of rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Linear Models; Male; Methotrexate; Middle Aged; Receptors, Interleukin-2; Regression Analysis | 1994 |
Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Drug Interactions; Etodolac; Female; Humans; Male; Methotrexate; Middle Aged; Protein Binding | 1994 |
Prospidine versus methotrexate pulse in highly active rheumatoid arthritis: a controlled 6-month clinical trial.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Prospidium | 1994 |
A clinical and biochemical assessment of methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dyspepsia; Female; Humans; Methotrexate; Nausea; Stomatitis, Aphthous | 1994 |
Serum levels of interleukin-6 and tumour-necrosis-factor-alpha are not correlated to disease activity in patients with rheumatoid arthritis after treatment with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; C-Reactive Protein; Humans; Interleukin-6; Methotrexate; Middle Aged; Rheumatoid Factor; Tumor Necrosis Factor-alpha | 1994 |
Radiographic assessment of disease progression in rheumatoid arthritis patients enrolled in the cooperative systematic studies of the rheumatic diseases program randomized clinical trial of methotrexate, auranofin, or a combination of the two.
Topics: Adult; Aged; Arthritis, Rheumatoid; Arthrography; Auranofin; Drug Therapy, Combination; Female; Hand; Humans; Male; Methotrexate; Middle Aged; Wrist Joint | 1993 |
Aspirin is not associated with more toxicity than other nonsteroidal antiinflammatory drugs in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies | 1993 |
[Methotrexate therapy of rheumatoid arthritis. An open observation study of 110 patients with median length of treatment of 17.8 month].
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Time Factors | 1993 |
Methotrexate--the relationship between dose and clinical effect.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 1993 |
Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial.
Topics: Aged; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged | 1993 |
Better effect of methotrexate on C-reactive protein during daily compared to weekly treatment in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Methotrexate; Middle Aged | 1993 |
Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Postoperative Complications; Prospective Studies; Wound Healing; Wound Infection | 1993 |
Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthritis. Longitudinal evaluation during methotrexate and azathioprine therapy.
Topics: Arthritis, Rheumatoid; Azathioprine; Cytokines; Double-Blind Method; Humans; Interleukin-6; Longitudinal Studies; Methotrexate; Prospective Studies; Receptors, Cell Surface; Receptors, Interleukin-2; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 1993 |
The relative toxicity of disease-modifying antirheumatic drugs.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Humans; Hydroxychloroquine; Longitudinal Studies; Methotrexate; Penicillamine; Prednisone; Prospective Studies | 1993 |
Is there an interaction between low doses of corticosteroids and methotrexate in patients with rheumatoid arthritis? A pharmacokinetic study in 33 patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Prednisolone | 1993 |
The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1993 |
The effects of drug therapy on radiographic progression of rheumatoid arthritis. Results of a 36-week randomized trial comparing methotrexate and auranofin.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Auranofin; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index | 1993 |
Low-dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. Results of a multicenter randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Placebos | 1993 |
Combining sulphasalazine and methotrexate in rheumatoid arthritis: early clinical impressions.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine | 1995 |
Does methotrexate affect serum level of IgA-alpha-1 antitrypsin complex in early rheumatoid arthritis?
Topics: Adolescent; Adult; Aged; alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Immunoglobulin A; Male; Methotrexate; Middle Aged; Orosomucoid | 1995 |
Problems and suggested solutions in creating an archive of clinical trials data to permit later meta-analysis: an example of methotrexate trials in rheumatoid arthritis.
Topics: Archives; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Meta-Analysis as Topic; Methotrexate; Software | 1995 |
[Treatment of rheumatoid arthritis of senile onset with methotrexate].
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate | 1995 |
Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome | 1996 |
Results of controlled study of combination therapy with azathioprine and methotrexate in the treatment of rheumatoid arthritis revisited: comment on the article by Willkens et al.
Topics: Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Humans; Methotrexate | 1996 |
Long-term tolerability of methotrexate at doses exceeding 15 mg per week in rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Drug Administration Schedule; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Longitudinal Studies; Lung Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors; Treatment Refusal | 1996 |
Duodenal mucosal ferritin in rheumatoid arthritis: implications for anaemia of chronic disease.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Duodenum; Female; Ferritins; Gastric Mucosa; Gold; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Methotrexate; Middle Aged | 1996 |
Combination therapy of cyclosporine A with methotrexate or hydroxychloroquine in refractory rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Treatment Outcome | 1996 |
Major infection during methotrexate treatment for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Humans; Methotrexate; Opportunistic Infections; Prospective Studies | 1996 |
[Prospective clinical study of the combination therapy of auranofin and methotrexate for rheumatoid arthritis--a multi-center study].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1996 |
Lack of interaction between bromfenac and methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Analgesics; Arthritis, Rheumatoid; Benzophenones; Bromobenzenes; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged | 1996 |
Do changes in clinical improvement in rheumatoid arthritis patients treated with immunosuppressive drugs reflect the changes in acute phase proteins?
Topics: Acute-Phase Proteins; Adult; alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Arthritis, Rheumatoid; C-Reactive Protein; Cyclophosphamide; Cyclosporine; Female; Follow-Up Studies; Humans; Immunoelectrophoresis; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Orosomucoid | 1995 |
Combination therapy with cyclosporin in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Forecasting; Humans; Methotrexate; Rheumatology | 1996 |
Effects on fibrogenesis markers of rheumatoid arthritis therapy with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Laminin; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Peptide Fragments; Procollagen | 1996 |
Oral administration of an easily prepared solution of injectable methotrexate diluted in water: A comparison of serum concentrations vs methotrexate tablets and clinical utility.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Indicator Dilution Techniques; Injections; Male; Methotrexate; Middle Aged; Tablets; Water | 1996 |
Significant changes in serum AST across hepatic histological biopsy grades: prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Sensitivity and Specificity | 1996 |
Combination treatment of rheumatoid arthritis using azathioprine and methotrexate: a 48 week controlled clinical trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Azathioprine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1996 |
Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 1996 |
B lymphocytic clonal expansion in rheumatoid arthritis.
Topics: Adult; Antigens, CD; Arthritis, Rheumatoid; B-Lymphocytes; Base Sequence; Blood Cells; Clone Cells; Female; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; Molecular Sequence Data; Osteoarthritis; Statistics, Nonparametric; White People | 1996 |
Comparison of azathioprine, methotrexate, and the combination of the two in the treatment of rheumatoid arthritis. A forty-eight-week controlled clinical trial with radiologic outcome assessment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Azathioprine; Blood Sedimentation; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome; United States | 1995 |
Combination of methotrexate and sulphasalazine in patients with rheumatoid arthritis: pharmacokinetic analysis and relationship to clinical response.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biological Availability; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Sulfasalazine | 1996 |
Lack of interaction between flucloxacillin and methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Floxacillin; Humans; Male; Methotrexate; Middle Aged | 1996 |
Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Joint Prosthesis; Male; Methotrexate; Middle Aged; Prospective Studies; Prosthesis-Related Infections; Staphylococcal Infections; Surgical Wound Infection | 1996 |
Serum phospholipase A2 activity in patients with rheumatoid arthritis before and after treatment with methotrexate, auranofin, or combination of the two.
Topics: Adult; Arthritis, Rheumatoid; Auranofin; Double-Blind Method; Drug Combinations; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Pain; Phospholipases A; Phospholipases A2 | 1996 |
The frequency and clinical characteristics of methotrexate (MTX) oral toxicity in rheumatoid arthritis (RA): a masked and controlled study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Oral Ulcer; Prevalence; Single-Blind Method; Stomatitis; Time Factors | 1996 |
A modified version of Larsen's scoring method to assess radiologic changes in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Arthrography; Disease Progression; Double-Blind Method; Evaluation Studies as Topic; Gold Sodium Thiomalate; Humans; Methotrexate | 1995 |
[Combined immunomodulating therapy in rheumatoid arthritis].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peptides; Thymus Extracts; Time Factors | 1996 |
Relationship of soluble interleukin-2-receptor and interleukin-6 with class-specific rheumatoid factors during low-dose methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Interleukin-6; Male; Methotrexate; Middle Aged; Receptors, Interleukin-2; Rheumatoid Factor; Solubility | 1997 |
Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Regression Analysis | 1997 |
Comparison of intramuscular methotrexate and gold sodium thiomalate in the treatment of early erosive rheumatoid arthritis: 12 month data of a double-blind parallel study of 174 patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Double-Blind Method; Female; Gold Sodium Thiomalate; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Time Factors | 1997 |
Prospectively measured red cell folate levels in methotrexate treated patients with rheumatoid arthritis: relation to withdrawal and side effects.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Lactoglobulins; Male; Methotrexate; Middle Aged; Prospective Studies; Radioligand Assay; Substance Withdrawal Syndrome | 1997 |
Lack of pharmacokinetic interaction of meloxicam with methotrexate in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Male; Meloxicam; Methotrexate; Middle Aged; Thiazines; Thiazoles | 1997 |
Methotrexate use in systemic lupus erythematosus.
Topics: Adult; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Immunosuppressive Agents; Life Tables; Lupus Erythematosus, Systemic; Male; Methotrexate; Probability | 1997 |
Clinical characteristics related to methotrexate-induced pancytopenia.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Monitoring, Physiologic; Pancytopenia; Risk Factors | 1997 |
Magnetic resonance imaging of the wrist in defining remission of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Contrast Media; Evaluation Studies as Topic; Female; Gadolinium DTPA; Humans; Hydroxychloroquine; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Organometallic Compounds; Pentetic Acid; Remission Induction; Remission, Spontaneous; Wrist | 1997 |
Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Sulfasalazine; Treatment Outcome | 1997 |
Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Calcium; Cholecalciferol; Drug Therapy, Combination; Female; Femur Neck; Humans; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Osteoporosis; Prednisone; Prospective Studies | 1997 |
[The effect of immunosuppressive drugs on expression of surface antigens of lymphocytes in patients with rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Surface; Arthritis, Rheumatoid; B-Lymphocytes; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Lymphocyte Count; Lymphocytes; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Prednisone; T-Lymphocytes | 1997 |
Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis.
Topics: Alkaline Phosphatase; Antirheumatic Agents; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate | 1997 |
Long-term treatment of destructive rheumatoid arthritis with methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Treatment Outcome | 1997 |
Safety and efficacy of hydroxychloroquine as maintenance therapy for rheumatoid arthritis after combination therapy with methotrexate and hydroxychloroquine.
Topics: Aged; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 1997 |
Combination treatment of severe rheumatoid arthritis with cyclosporine and methotrexate for forty-eight weeks: an open-label extension study. The Methotrexate-Cyclosporine Combination Study Group.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 1997 |
Radiosynoviorthesis with rhenium-186 in rheumatoid arthritis: a prospective study of three treatment regimens.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Injections, Intra-Articular; Male; Methotrexate; Pain Measurement; Patient Selection; Prednisolone; Prospective Studies; Radioisotopes; Range of Motion, Articular; Recurrence; Rhenium; Synovitis; Treatment Outcome; Triamcinolone Acetonide | 1997 |
Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; HLA-DR1 Antigen; HLA-DR4 Antigen; Humans; Incidence; Male; Methotrexate; Middle Aged; Nausea; Rheumatoid Factor; Severity of Illness Index; Sulfasalazine; Surveys and Questionnaires | 1997 |
Fluoride therapy in prevention of rheumatoid arthritis induced bone loss.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Resorption; Cell Division; Double-Blind Method; Female; Humans; Lumbosacral Region; Male; Methotrexate; Middle Aged; Osteoblasts; Prednisone; Sodium Fluoride | 1997 |
Antiinflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis: evidence of increased interleukin-4 and interleukin-10 gene expression demonstrated in vitro by competitive reverse transcriptase-polymerase chain react
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-4; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Polymerase Chain Reaction | 1998 |
[The effect of low dose methotrexate on the course of rheumatoid arthritis--four years of observation].
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Prednisone; Radiography; Treatment Outcome | 1997 |
Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy.
Topics: Arthritis, Rheumatoid; Biopsy; Cross-Over Studies; Drug Therapy, Combination; Humans; Liver; Longitudinal Studies; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Treatment Outcome | 1998 |
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 1998 |
[Combined drug therapy in recent-onset rheumatoid arthritis. Evaluation after 1 year of treatment].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Time Factors | 1998 |
[Combination therapy in early rheumatoid arthritis: the COBRA study].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Double-Blind Method; Drug Therapy, Combination; Humans; Joints; Methotrexate; Prednisolone; Sulfasalazine | 1997 |
[Long-term combination therapy of chronic polyarthritis: methotrexate and parenteral gold].
Topics: Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infusions, Parenteral; Methotrexate; Organogold Compounds; Treatment Outcome | 1998 |
The effects of non-steroidal anti-inflammatory drugs on the disposition of methotrexate in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 1998 |
Influence of biological variables upon pharmacokinetic parameters of intramuscular methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Bayes Theorem; Female; Fluorescence Polarization Immunoassay; Half-Life; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1998 |
Efficacy of methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Asthma; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction | 1997 |
Inhibition of interleukin-8 synthesis by intraarticular methotrexate therapy in patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Injections, Intra-Articular; Interleukin-8; Knee Joint; Methotrexate; Middle Aged; Synovial Fluid | 1998 |
Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Adhesion Molecules; Cell Count; Humans; Immunoenzyme Techniques; Knee Joint; Leukocytes; Methotrexate; Monokines; Synovial Membrane; Treatment Outcome | 1998 |
Ondansetron prevents refractory and severe methotrexate-induced nausea in rheumatoid arthritis.
Topics: Antiemetics; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Nausea; Ondansetron; Retrospective Studies; Treatment Outcome | 1998 |
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Double-Blind Method; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Lymphokines; Methotrexate; Receptors, Interleukin-1; Sialoglycoproteins; Synovial Membrane; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Experience with methotrexate-associated pneumonitis in northeastern England: comment on the article by Kremer et al.
Topics: Aged; Arthritis, Rheumatoid; England; Fatal Outcome; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged; Pneumonia; Risk | 1998 |
Is there an optimal time to administer methotrexate in the treatment of rheumatoid arthritis?
Topics: Adult; Aged; Arthritis, Rheumatoid; Circadian Rhythm; Cross-Over Studies; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Treatment Outcome | 1998 |
Bayesian calculation of methotrexate clearance after low dose intramuscular administration in patients with rheumatoid arthritis.
Topics: Adult; Aged; Area Under Curve; Arthritis, Rheumatoid; Bayes Theorem; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1998 |
Longterm combination therapy of refractory and destructive rheumatoid arthritis with methotrexate (MTX) and intramuscular gold or other disease modifying antirheumatic drugs compared to MTX monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 1998 |
Injection of the rheumatoid knee: does intra-articular methotrexate or rifampicin add to the benefits of triamcinolone hexacetonide?
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Intra-Articular; Knee Joint; Male; Methotrexate; Middle Aged; Pain; Rifampin; Severity of Illness Index; Treatment Outcome; Triamcinolone Acetonide | 1998 |
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Safety; Treatment Outcome; Tumor Necrosis Factor-alpha | 1998 |
Long-term followup of patients receiving combined therapy with cyclosporine and methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 1998 |
[Pulse therapy with prospidin and methotrexate: comparative efficacy in rheumatoid arthritis (12-month controlled study)].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospidium; Treatment Outcome | 1998 |
Validation of rheumatoid arthritis improvement criteria that include simplified joint counts.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Joints; Methotrexate; Reproducibility of Results; Sulfasalazine; Treatment Outcome | 1998 |
The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Individuality; Male; Methotrexate; Middle Aged; Models, Biological; Population Surveillance; Time Factors | 1998 |
Effect of low dose methotrexate on markers of bone metabolism in patients with rheumatoid arthritis.
Topics: Adult; Alkaline Phosphatase; Amino Acids; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Bone and Bones; Bone Resorption; C-Reactive Protein; Dose-Response Relationship, Drug; Female; Humans; Isoenzymes; Methotrexate; Severity of Illness Index | 1998 |
A 36 month comparative trial of methotrexate and gold sodium thiomalate in the treatment of early active and erosive rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Humans; Joints; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prospective Studies; Severity of Illness Index; Treatment Outcome | 1998 |
Cost-effectiveness and cost-utility of combination therapy in early rheumatoid arthritis: randomized comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone. COBRA Trial Group. Combinatietherapie Bij Reumat
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 1998 |
Can collagen type II sustain a methotrexate-induced therapeutic effect in patients with long-standing rheumatoid arthritis? A double-blind, randomized trial.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen; Disease Progression; Double-Blind Method; Female; Humans; Immune Tolerance; Joints; Male; Methotrexate; Middle Aged; Mouth Mucosa; Treatment Outcome | 1998 |
Progression in early erosive rheumatoid arthritis: 12 month results from a randomized controlled trial comparing methotrexate and gold sodium thiomalate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Female; Gold Sodium Thiomalate; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 1998 |
Comparative study of the clinical efficacy of four DMARDs (leflunomide, methotrexate, cyclosporine, and levamisole) in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Levamisole; Male; Methotrexate; Middle Aged | 1998 |
Comparative studies of quality and bioavailability of methotrexate in Thai patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged | 1998 |
Sensitivity to change of generic quality of life instruments in patients with rheumatoid arthritis: preliminary findings in the generic health OMERACT study. OMERACT/ILAR Task Force on Generic Quality of Life. Life Outcome Measures in Rheumatology. Intern
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Quality of Life; Sensitivity and Specificity; Surveys and Questionnaires | 1999 |
A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome | 1999 |
Use of methotrexate in the management of rheumatoid arthritis in Dakar. Potential pitfalls.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hospitals, Teaching; Humans; Male; Methotrexate; Middle Aged; Senegal; Severity of Illness Index; Treatment Outcome | 1998 |
Radiologic progression in early rheumatoid arthritis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Treatment Outcome | 1999 |
[Measure of bone loss in rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Adult; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Densitometry; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Osteoporosis; Osteoporosis, Postmenopausal | 1999 |
Smallest detectable difference in radiological progression.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Observer Variation; Prednisolone; Radiography; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 1999 |
[Efficacy of D-penicillamine and methotrexate in the treatment of rheumatoid arthritis in relation to levels of circulating rheumatoid factors of different classes].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Immunoenzyme Techniques; Immunoglobulin G; Male; Methotrexate; Middle Aged; Penicillamine; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 1999 |
Prospective six year follow up of patients withdrawn from a randomised study comparing parenteral gold salt and methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Follow-Up Studies; Gold Sodium Thiomalate; Humans; Injections, Intramuscular; Male; Methotrexate; Recurrence; Treatment Outcome | 1999 |
Comparison of combination therapy with single-drug therapy in early rheumatoid arthritis: a randomised trial. FIN-RACo trial group.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisolone; Remission Induction; Sulfasalazine | 1999 |
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12 | 1999 |
Efficacy and safety of a combination therapy of methotrexate, chloroquine and cyclophosphamide in patients with refractory rheumatoid arthritis: results of an observational study with matched-pair analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cohort Studies; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Joints; Male; Matched-Pair Analysis; Methotrexate; Middle Aged; Treatment Outcome | 1999 |
Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Headache; Humans; Male; Methotrexate; Middle Aged; Nausea; Sulfasalazine | 1999 |
Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis.
Topics: Adult; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspartate Aminotransferases; Diarrhea; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver; Male; Methotrexate; Middle Aged; Nausea; Patient Compliance; Treatment Outcome | 1999 |
Function and health-related quality of life: results from a randomized controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group.
Topics: Adjuvants, Immunologic; Adult; Aged; Arthritis, Rheumatoid; Disability Evaluation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Placebos; Quality of Life | 1999 |
Comparison of two schedules for administering oral low-dose methotrexate (weekly versus every-other-week) in patients with rheumatoid arthritis in remission: a twenty-four week, single blind, randomized study.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Remission Induction; Treatment Outcome | 1999 |
The safety and efficacy of cyclosporine (Neoral) in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 1999 |
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine | 1999 |
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Transaminases; Treatment Outcome | 1999 |
Celecoxib, a specific COX-2 inhibitor, has no significant effect on methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Humans; Isoenzymes; Kidney; Male; Membrane Proteins; Methotrexate; Middle Aged; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Single-Blind Method; Sulfonamides; Urine | 1999 |
Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Double-Blind Method; Female; Humans; Infliximab; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Placebos; Remission Induction; Sensitivity and Specificity; Tumor Necrosis Factor-alpha | 1999 |
Additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, sulfasalazine and methotrexate in the treatment of rheumatoid arthritis: a clinical trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine; Sulfhydryl Compounds | 1999 |
Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Life Expectancy; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Survival Analysis; Treatment Outcome | 2000 |
Disease modification in rheumatoid arthritis with leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Time Factors | 1999 |
Leflunomide improves quality of life in rheumatoid arthritis.
Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Quality of Life; Sulfasalazine | 1999 |
Leflunomide versus methotrexate: a comparison of the European and American experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Europe; Female; Folic Acid; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; United States | 1999 |
Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Leflunomide Rheumatoid Arthritis Investigators Group.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Isoxazoles; Leflunomide; Methotrexate; Placebos; Radiography; Sulfasalazine | 2000 |
Clinical improvement as reflected in measures of function and health-related quality of life following treatment with leflunomide compared with methotrexate in patients with rheumatoid arthritis: sensitivity and relative efficiency to detect a treatment e
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Quality of Life; Treatment Outcome | 2000 |
Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Female; Hand; Humans; Hypertension; Male; Methotrexate; Nausea; Prospective Studies; Radiography; Time Factors; Wrist | 2000 |
Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Double-Blind Method; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pilot Projects; Recombinant Fusion Proteins; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2000 |
Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Female; Humans; Indoles; Interleukin-6; Linear Models; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Oxindoles; Predictive Value of Tests; Severity of Illness Index; Treatment Outcome | 2000 |
A clinical study of CPH 82 vs methotrexate in early rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Double-Blind Method; Female; Glycosides; Humans; Joints; Lignans; Male; Methotrexate; Middle Aged; Pain; Severity of Illness Index; Treatment Outcome | 2000 |
Radiological and clinical results of longterm treatment of rheumatoid arthritis with methotrexate and azathioprine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2000 |
Aggressive treatment in early rheumatoid arthritis: a randomised controlled trial. On behalf of the Rheumatic Research Foundation Utrecht, The Netherlands.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Penicillamine; Prospective Studies; Sulfasalazine | 2000 |
Enhanced production of tissue inhibitor of metalloproteinases by peripheral blood mononuclear cells of rheumatoid arthritis patients responding to methotrexate treatment.
Topics: Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Interleukin-6; Leukocytes, Mononuclear; Male; Matrix Metalloproteinase 1; Methotrexate; Middle Aged; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Outcome Assessment, Health Care; Radiography; Treatment Outcome | 2000 |
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients.
Topics: Aged; Aniline Compounds; Antirheumatic Agents; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Crotonates; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydroxybutyrates; Immunosuppressive Agents; In Vitro Techniques; Interleukin-8; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Prospective Studies; Toluidines | 2000 |
Treatment of poor-prognosis early rheumatoid arthritis. A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cyclosporine; Drug Therapy, Combination; Humans; Injections, Intra-Articular; Methotrexate; Patient Dropouts; Prognosis; Regression Analysis; Sulfasalazine; Therapeutic Equivalency; Treatment Outcome | 2000 |
Treatment of rheumatoid arthritis with a DR4/1 peptide.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; B-Lymphocytes; Double-Blind Method; Drug Therapy, Combination; Female; Flow Cytometry; HLA-DR4 Antigen; Humans; Immunization, Secondary; Injections, Intramuscular; Lymphocyte Activation; Lymphocyte Count; Male; Methotrexate; Middle Aged; Monocytes; Oligopeptides; Receptors, Antigen, T-Cell, alpha-beta; Safety; T-Lymphocytes; Treatment Outcome | 2000 |
Folic acid alters methotrexate availability in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 2000 |
Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2000 |
A cost-effectiveness analysis of treatment options for patients with methotrexate-resistant rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Resistance; Humans; Methotrexate; Reference Values; Sensitivity and Specificity; Therapeutic Equivalency; Treatment Outcome | 2000 |
The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years.
Topics: Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Double-Blind Method; Female; Gene Frequency; Gold Sodium Thiomalate; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Methotrexate; Rheumatoid Factor | 2000 |
A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Bone and Bones; Disease Progression; Etanercept; Female; Humans; Immunoglobulin G; Injections, Subcutaneous; Joints; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2000 |
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Female; Humans; Infliximab; Injections, Intravenous; Joints; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2000 |
Toxicity of anti-rheumatic drugs in a randomized clinical trial of early rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Organogold Compounds; Prospective Studies; Treatment Outcome | 2000 |
Combination therapy with hydroxychloroquine, gold sodium thiomalate and methotrexate in early rheumatoid arthritis. An open 3-year study.
Topics: Adult; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2000 |
Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Elective Surgical Procedures; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Orthopedic Procedures; Postoperative Complications; Risk Factors; Surgical Wound Infection | 2001 |
Efficacy of sulphasalazine plus methotrexate in rheumatoid arthritis.
Topics: Adult; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Drug Combinations; Female; Follow-Up Studies; Hemoglobins; Humans; Incidence; Leukocyte Count; Male; Methotrexate; Nausea; Neutrophils; Prospective Studies; Remission Induction; Statistics, Nonparametric; Sulfasalazine | 2000 |
Self-injection of gold and methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Administration Routes; Female; Gold Compounds; Granulomatosis with Polyangiitis; Humans; Injections, Intramuscular; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Pilot Projects; Polymyositis; Self Administration; Treatment Outcome | 2001 |
Alendronate in rheumatoid arthritis patients treated with methotrexate and glucocorticoids.
Topics: Absorptiometry, Photon; Aged; Alendronate; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Calcium; Clinical Chemistry Tests; Drug Therapy, Combination; Female; Hematologic Tests; Humans; Methotrexate; Middle Aged; Osteoporosis, Postmenopausal; Prednisolone; Treatment Outcome | 2001 |
Doxycycline in the treatment of rheumatoid arthritis--a pilot study.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Doxycycline; Female; Follow-Up Studies; Humans; India; Male; Methotrexate; Middle Aged; Single-Blind Method; Treatment Outcome | 2000 |
Treatment with cyclosporin switching to hydroxychloroquine in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Female; Humans; Hydroxychloroquine; Hypertension; Hypertrichosis; Linear Models; Male; Methotrexate; Middle Aged; Pilot Projects; Treatment Outcome | 2001 |
Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived area.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Glucocorticoids; Gold Sodium Thiomalate; Health Status Indicators; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Poverty Areas; Treatment Outcome | 2001 |
American College of Rheumatology criteria for improvement in rheumatoid arthritis should only be calculated from scores that decrease on improvement.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Prednisolone; Rheumatology; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2001 |
Antioxidants as adjuvant therapy in rheumatoid disease. A preliminary study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Indomethacin; Male; Methotrexate; Middle Aged; Sulfasalazine; Vitamin E | 2001 |
[Low dose steroid therapy in rheumatoid arthritis: a model for therapy of inflammatory diseases?--Results of the LDPT Study].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gold Sodium Thiomalate; Humans; Long-Term Care; Male; Methotrexate; Middle Aged; Prednisolone | 2001 |
Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Hematinics; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Placebos; Prospective Studies; Treatment Outcome | 2001 |
Influence of longterm therapy with methotrexate and low dose corticosteroids on type 1 and type 2 cytokine production in CD4+ and CD8+ T lymphocytes of patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Male; Methotrexate; Severity of Illness Index | 2001 |
[Double-blind trial of the effectiveness of antibodies to interferon-gamma and tumor necrosis factor-alpha in rheumatoid arthritis (preliminary results)].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunotherapy; Injections, Intramuscular; Interferon-gamma; Male; Methotrexate; Middle Aged; Prednisolone; Time Factors; Tumor Necrosis Factor-alpha | 2001 |
A randomized, controlled, single-blind trial of leflunomide in the treatment of rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Oxaprozin; Propionates; Single-Blind Method | 2001 |
Lack of pharmacokinetic interaction between rofecoxib and methotrexate in rheumatoid arthritis patients.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Confidence Intervals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Folic Acid Antagonists; Humans; Lactones; Male; Methotrexate; Middle Aged; Sulfones | 2001 |
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2001 |
Inflammation and damage in an individual joint predict further damage in that joint in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Inflammation; Joints; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisolone; Prognosis; Sulfasalazine | 2001 |
The effect of low dose methotrexate on bone density.
Topics: Absorptiometry, Photon; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Osteoporosis; Prospective Studies; Severity of Illness Index | 2001 |
Bone turnover, joint damage and bone mineral density in early rheumatoid arthritis treated with combination therapy including high-dose prednisolone.
Topics: Adult; Aged; Amino Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Remodeling; Collagen; Cross-Linking Reagents; Drug Therapy, Combination; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Postmenopause; Prednisolone; Regression Analysis; Sulfasalazine | 2001 |
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hematinics; Humans; Liver; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Severity of Illness Index; Treatment Outcome | 2001 |
Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis.
Topics: Adult; Amino Acids; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Collagen Type II; Cross-Linking Reagents; Etanercept; Female; Galactosides; Glucose; Glycosuria; Humans; Immunoglobulin G; Joints; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Peptide Fragments; Prospective Studies; Receptors, Tumor Necrosis Factor | 2002 |
Economic comparison of leflunomide and methotrexate in patients with rheumatoid arthritis: an evaluation based on a 1-year randomised controlled trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Economics, Pharmaceutical; Health Care Costs; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Ontario; Treatment Outcome | 2002 |
COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisolone; Radiography; Sensitivity and Specificity; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2002 |
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prospective Studies; Synovitis; Treatment Outcome | 2002 |
Radiographic outcome after three years of patients with early erosive rheumatoid arthritis treated with intramuscular methotrexate or parenteral gold. Extension of a one-year double-blind study in 174 patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Gold Sodium Thiomalate; Humans; Joints; Methotrexate; Middle Aged; Radiography; Treatment Outcome | 2002 |
Health-related quality of life in early rheumatoid arthritis: impact of disease and treatment response.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pain Measurement; Receptors, Tumor Necrosis Factor; Sickness Impact Profile; Surveys and Questionnaires; Treatment Outcome; United States | 2002 |
Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial.
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Recombinant Proteins; Safety; Severity of Illness Index; Sialoglycoproteins; Treatment Outcome | 2002 |
Step-down approach using either cyclosporin A or methotrexate as maintenance therapy in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Feasibility Studies; Female; Humans; Joints; Male; Methotrexate; Middle Aged | 2002 |
Investigation of the chronic pulmonary effects of low-dose oral methotrexate in patients with rheumatoid arthritis: a prospective study incorporating HRCT scanning and pulmonary function tests.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prospective Studies; Pulmonary Fibrosis; Radiography, Thoracic; Respiratory Function Tests; Tomography, X-Ray Computed | 2002 |
Open label study to assess infliximab safety and timing of onset of clinical benefit among patients with rheumatoid arthritis.
Topics: Ambulatory Care; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Infusions, Intravenous; Joints; Male; Methotrexate; Middle Aged; Outpatients; Pain; Severity of Illness Index; Time Factors; Treatment Outcome | 2002 |
Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisolone; Remission Induction; Sulfasalazine; Treatment Outcome | 2002 |
Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-alpha antibody compared with methotrexate in long-standing rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Methotrexate; Patient Dropouts; Predictive Value of Tests; Proportional Hazards Models; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2002 |
Serum matrix metalloproteinase 3 levels during treatment with sulfasalazine or combination of methotrexate and sulfasalazine in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Prospective Studies; Sulfasalazine | 2002 |
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 2002 |
[Synchronous programmed intensive therapy of patients with severe rheumatoid arthritis].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Plasmapheresis | 2002 |
Methotrexate in the treatment of rheumatoid arthritis. II. In vivo effects on bone mineral density.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Osteoporosis, Postmenopausal; Outpatient Clinics, Hospital; Prospective Studies; Sulfasalazine | 2002 |
Intra-articular methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Humans; Injections, Intra-Articular; Knee Joint; Methotrexate | 1976 |
Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic arthritis.
Topics: Adult; Aged; Arthritis; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Psoriasis; Synovial Fluid | 1978 |
Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Dose-Response Relationship, Drug; Double-Blind Method; Echocardiography; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Myocardium; Radiography, Thoracic; Rheumatoid Nodule; Skin | 1992 |
Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
Topics: Adult; Alkaline Phosphatase; Aminopterin; Arthritis, Rheumatoid; Aspartate Aminotransferases; Double-Blind Method; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 1992 |
[A comparative evaluation of combined immunocorrective therapy in rheumatoid arthritis with systemic manifestations (joint Soviet-Polish research)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Combined Modality Therapy; Cyclophosphamide; Drug Therapy, Combination; Female; Hemoperfusion; Humans; Male; Methotrexate; Middle Aged; Poland; USSR | 1992 |
The effects of methotrexate on interleukin 1 in patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1; Male; Methotrexate; Middle Aged; Monocytes; Prospective Studies; Time Factors; Zymosan | 1992 |
Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Auranofin; Double-Blind Method; Drug Therapy, Combination; Humans; Leukopenia; Methotrexate; Middle Aged; Thrombocytopenia | 1992 |
A prospective analysis of liver biopsies in rheumatoid arthritis patients receiving long term methotrexate therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Cohort Studies; Female; Humans; Liver; Methotrexate; Middle Aged; Prospective Studies; Time Factors | 1992 |
[The treatment of rheumatoid arthritis with low dose pulse methotrexate--comparative study with other disease modifying antirheumatic drugs].
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 1992 |
Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
Topics: Aminopterin; Arthritis, Rheumatoid; Double-Blind Method; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Treatment Outcome | 1992 |
High dose intravenous methotrexate for refractory rheumatoid arthritis.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Middle Aged; Time Factors | 1992 |
Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Digestive System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Statistics as Topic; Time Factors | 1992 |
Toxicity profiles of disease modifying antirheumatic drugs in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Female; Follow-Up Studies; Gold; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Penicillamine | 1991 |
Long-term prospective study of methotrexate in the treatment of rheumatoid arthritis. 84-month update.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Drug Administration Schedule; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Pain; Prednisone; Prospective Studies; Pulmonary Fibrosis; Radiography; Treatment Outcome | 1992 |
A double-blind comparison of parenteral methotrexate and parenteral gold in the treatment of early erosive rheumatoid arthritis: an interim report on 102 patients after 12 months.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Arthrography; Blood Sedimentation; Double-Blind Method; Female; Gold Sodium Thiomalate; Humans; Infusions, Parenteral; Joints; Male; Methotrexate; Middle Aged; Pain; Severity of Illness Index | 1991 |
Treatment of rheumatoid arthritis with methotrexate: a prospective open longterm study of 191 cases.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Digestive System; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors | 1991 |
Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged | 1991 |
IgM-rheumatoid factor and responses to second-line drugs in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Auranofin; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin M; Male; Methotrexate; Middle Aged; Monocytes; Prednisolone; Rheumatoid Factor | 1991 |
Methotrexate in rheumatoid arthritis: effects on disease activity in a multicenter prospective study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors | 1991 |
Methotrexate versus azathioprine in the treatment of rheumatoid arthritis. A forty-eight-week randomized, double-blind trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Methotrexate; Middle Aged; Time Factors | 1991 |
Analysis of methotrexate treatment effect in a longitudinal observational study: utility of cluster analysis.
Topics: Arthritis, Rheumatoid; Cluster Analysis; Female; Humans; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Severity of Illness Index; Surveys and Questionnaires | 1991 |
Treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dietary Fats, Unsaturated; Humans; Immunotherapy; Methotrexate | 1991 |
A double blind randomized parallel trial of intramuscular methotrexate and gold sodium thiomalate in early erosive rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Arthrography; Dose-Response Relationship, Drug; Double-Blind Method; Foot Deformities; Gold Sodium Thiomalate; Hand Deformities; Humans; Injections, Intramuscular; Joints; Methotrexate; Middle Aged | 1991 |
The efficacy and toxicity of a constant low dose of methotrexate as a treatment for intractable rheumatoid arthritis: an open prospective study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blood Sedimentation; Bone Marrow Diseases; C-Reactive Protein; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Kidney Failure, Chronic; Liver; Male; Methotrexate; Middle Aged; Prospective Studies | 1991 |
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate | 1991 |
The use of combinations of disease-modifying antirheumatic agents in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclophosphamide; Drug Combinations; Gold; Humans; Methotrexate; Penicillamine; Sulfasalazine | 1990 |
The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses.
Topics: Antimalarials; Arthritis, Rheumatoid; Auranofin; Gold; Humans; Meta-Analysis as Topic; Methotrexate; Penicillamine; Sulfasalazine | 1990 |
Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis. A randomized, double-blind study.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Double-Blind Method; Female; Foot; Hand; Humans; Male; Methotrexate; Middle Aged; Radiography; Wrist Joint | 1991 |
Adverse experience with methotrexate during 176 weeks of a longterm prospective trial in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Creatine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Humans; Leukocyte Count; Male; Methotrexate; Prospective Studies; Time Factors | 1990 |
Radiologic progression during intramuscular methotrexate treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Arthrography; Double-Blind Method; Female; Humans; Injections, Intramuscular; Joint Diseases; Joints; Male; Methotrexate; Middle Aged; Time Factors | 1990 |
Analysis of improvement in individual rheumatoid arthritis patients treated with disease-modifying antirheumatic drugs, based on the findings in patients treated with placebo. The Cooperative Systematic Studies of Rheumatic Diseases Group.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Auranofin; Azathioprine; Double-Blind Method; Drug Therapy, Combination; Gold Sodium Thiomalate; Humans; Methotrexate; Middle Aged; Penicillamine; Placebo Effect; Prospective Studies; Randomized Controlled Trials as Topic | 1990 |
Second-line antirheumatic drugs in the elderly with rheumatoid arthritis: a post hoc analysis of three controlled trials.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Auranofin; Azathioprine; Double-Blind Method; Drug Evaluation; Female; Gold Sodium Thiomalate; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Penicillamine; Prospective Studies; Random Allocation; Time Factors | 1990 |
Administration of folinic acid after low dose methotrexate in patients with rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged | 1990 |
Low-dose methotrexate compared with auranofin in adult rheumatoid arthritis. A thirty-six-week, double-blind trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Auranofin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic | 1990 |
Comparative controlled trial of low-dose weekly methotrexate versus azathioprine in rheumatoid arthritis: 3-year prospective study.
Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Blood Chemical Analysis; Blood Sedimentation; Clinical Trials as Topic; Female; Humans; Male; Methotrexate; Middle Aged; Movement; Pain Measurement; Prospective Studies; Random Allocation | 1990 |
[The efficacy of immunomodulating therapy in rheumatoid arthritis].
Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Peptides; Randomized Controlled Trials as Topic; Thymus Extracts; Time Factors | 1990 |
Clinical and laboratory outcomes during the treatment of rheumatoid arthritis with methotrexate.
Topics: Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Edema; Fluorescent Antibody Technique; Humans; Latex Fixation Tests; Methotrexate; Prognosis; Randomized Controlled Trials as Topic; Rheumatoid Factor | 1990 |
Aspirin, hydroxychloroquine, and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis.
Topics: Alanine Transaminase; Analysis of Variance; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Canada; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Liver; Methotrexate; Product Surveillance, Postmarketing; Prospective Studies; Regression Analysis; United States | 1990 |
Azathioprine and methotrexate as combination chemotherapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; Multicenter Studies as Topic; Structure-Activity Relationship | 1990 |
Methotrexate in rheumatoid arthritis. Impact on quality of life assessed by traditional standard-item and individualized patient preference health status questionnaires.
Topics: Adult; Arthritis, Rheumatoid; Double-Blind Method; Health Status Indicators; Humans; Methotrexate; Quality of Life; Randomized Controlled Trials as Topic; Surveys and Questionnaires | 1990 |
The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Folic Acid; Humans; Methotrexate; Patient Dropouts | 1990 |
Gold sodium thiomalate compared to low dose methotrexate in the treatment of rheumatoid arthritis--a randomized, double blind 26-week trial.
Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Gold Sodium Thiomalate; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Pain; Random Allocation | 1989 |
Which traditional measures should be used in rheumatoid arthritis clinical trials?
Topics: Administration, Oral; Arthritis, Rheumatoid; Auranofin; Clinical Trials as Topic; Factor Analysis, Statistical; Gold Sodium Thiomalate; Humans; Methotrexate; Penicillamine; Placebos; Regression Analysis | 1989 |
[The combination of cyclosporin A and fluocortolone in the treatment of autoimmune diseases].
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Clinical Trials as Topic; Cyclophosphamide; Cyclosporins; Drug Evaluation; Drug Therapy, Combination; Female; Fluocortolone; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Peptic Ulcer | 1989 |
Methotrexate therapy in the treatment of rheumatoid arthritis.
Topics: Absorption; Animals; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunity; Methotrexate | 1989 |
Increasing methotrexate effect with increasing dose in the treatment of resistant rheumatoid arthritis.
Topics: Activities of Daily Living; Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Physical Therapy Modalities; Random Allocation | 1989 |
Methotrexate for arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Liver; Methotrexate | 1986 |
Concurrent use of folinic acid and methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Erythrocyte Volume; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Severity of Illness Index | 1988 |
A randomized controlled trial of parenteral methotrexate compared with sodium aurothiomalate (Myochrysine) in the treatment of rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Gold Sodium Thiomalate; Humans; Infusions, Parenteral; Joints; Methotrexate; Middle Aged; Random Allocation; Severity of Illness Index | 1988 |
Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Prospective Studies; Random Allocation; T-Lymphocytes; Tablets | 1988 |
A long-term prospective study of the use of methotrexate in rheumatoid arthritis. Update after a mean of fifty-three months.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Central Nervous System Diseases; Clinical Trials as Topic; Gastrointestinal Diseases; HLA Antigens; Humans; Leukopenia; Methotrexate; Middle Aged; Mouth; Pain; Phenotype; Prospective Studies; Time Factors | 1988 |
Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy, and safety.
Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Injections, Intramuscular; Methotrexate | 1987 |
Low-dose methotrexate in rheumatoid arthritis: effect and tolerance. An open trial and a double-blind randomized study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Methotrexate; Middle Aged; Prospective Studies | 1986 |
[Methotrexate in the treatment of rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged | 1986 |
Lack of association between HLA-DR2 and clinical response to methotrexate in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; HLA-D Antigens; HLA-DR Antigens; HLA-DR2 Antigen; Humans; Methotrexate; Phenotype; Research Design | 1987 |
Severe flare of rheumatoid arthritis after discontinuation of long-term methotrexate therapy. Double-blind study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors | 1987 |
Low-dose methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. A twenty-four-week controlled clinical trial.
Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Random Allocation | 1987 |
Efficacy of low-dose methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; Random Allocation | 1985 |
Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial.
Topics: Administration, Oral; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged | 1985 |
Methotrexate for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate | 1985 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Gold; Humans; Immunosuppression Therapy; Methotrexate; Pancytopenia; Penicillamine; Placebos; Psoriasis | 1985 |
Historical perspective on the use of methotrexate for the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aminopterin; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Female; History, 20th Century; Humans; Male; Methotrexate; Pneumonia; Psoriasis; Random Allocation | 1985 |
Toxicity of low dose methotrexate in rheumatoid arthritis.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases | 1985 |
Weekly pulse methotrexate in rheumatoid arthritis. Clinical and immunologic effects in a randomized, double-blind study.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Humans; Immunoglobulin G; Immunoglobulin M; Leukocyte Count; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Random Allocation | 1985 |
Immunosuppressive drugs in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Nitrogen Mustard Compounds; Penicillamine | 1971 |
Immunosuppressive therapy. 1.
Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Blood Coagulation Disorders; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Dermatomyositis; Factor VIII; Hepatitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Prednisolone; Purpura, Thrombocytopenic; Scleroderma, Systemic | 1972 |
[Differential therapy of chronic progressive polyarthritis].
Topics: Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Clinical Trials as Topic; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 1972 |
[Immunosuppressive therapy of the rheumatoid arthritis. mutual evaluation of establishments within the frame of the AFG rheumatology in jena].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Evaluation Studies as Topic; Germany, East; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Procarbazine; Triaziquone | 1974 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Cystitis; Female; Herpes Zoster; Humans; Jaundice; Mechlorethamine; Mercaptopurine; Methotrexate | 1970 |
3565 other study(ies) available for methotrexate and Rheumatoid Arthritis
| Article | Year |
|---|---|
Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cell Survival; Collagen; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Molecular Structure; Tumor Cells, Cultured | 1997 |
Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Survival; Collagen; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Mice, Inbred DBA; Molecular Structure; Tumor Cells, Cultured | 1997 |
Synthesis and evaluation of novel fluorinated methotrexate derivatives for application to rheumatoid arthritis treatment.
Topics: Animals; Antibody Formation; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Female; Fluorine; Folic Acid Antagonists; Methotrexate; Mice; Models, Chemical; Rats; Rats, Inbred Lew; Stereoisomerism; T-Lymphocytes | 1997 |
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Fluorescent Dyes; Hydrolases; Minocycline; Models, Biological; Molecular Structure; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Streptomycin; Tetracycline | 2008 |
Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Gelsemium; Indole Alkaloids; Interleukin-1beta; Male; Methotrexate; Molecular Structure; Rats; Rats, Inbred Lew; Rats, Wistar; Tumor Necrosis Factor-alpha | 2016 |
Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Body Weight; Half-Life; Isothiocyanates; Mice; Neutrophils; Prodrugs; Rats, Sprague-Dawley; Rats, Wistar; Zebrafish | 2018 |
Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis.
Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Boronic Acids; Collagen Type II; Humans; Hydrogen Peroxide; Male; MCF-7 Cells; Methotrexate; Mice, Inbred DBA; Microsomes, Liver; Prodrugs; Solubility | 2018 |
Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis.
Topics: Aminopterin; Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; Injections, Intraperitoneal; Methotrexate; Molecular Structure; Prodrugs; Rats; Reactive Oxygen Species; Structure-Activity Relationship | 2020 |
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Freund's Adjuvant; Molecular Structure; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats; Sphingosine; Structure-Activity Relationship | 2021 |
Synthesis, activity and mechanism for double-ring conjugated enones.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cycloheptanes; Cyclohexanones; Rats; Signal Transduction; Synovial Fluid; Toll-Like Receptor 4 | 2021 |
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-
Topics: Administration, Oral; Animals; Area Under Curve; Arthritis, Rheumatoid; Calcium; Calcium Channel Blockers; Calcium Release Activated Calcium Channels; Clinical Trials, Phase I as Topic; Drug Discovery; Humans; Jurkat Cells; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred Lew; Structure-Activity Relationship | 2021 |
Ultrasound efficacy of targeted-synthetic disease-modifying anti-rheumatic drug treatment in rheumatoid arthritis: a multicenter prospective cohort study in Japan.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Japan; Methotrexate; Prospective Studies; Treatment Outcome; Ultrasonography | 2022 |
A rheumatoid arthritis patient with delivery who started certolizumab pegol and tacrolimus during pregnancy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Female; Humans; Methotrexate; Placenta; Pregnancy; Tacrolimus; Treatment Outcome | 2022 |
A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis.
Topics: Adolescent; Adult; Alarmins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Chromatography, Liquid; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Protein Isoforms; Serum Amyloid A Protein; Tandem Mass Spectrometry; Young Adult | 2021 |
Sarilumab monotherapy vs sarilumab and methotrexate combination therapy in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Fatigue; Humans; Methotrexate; Pain; Treatment Outcome | 2022 |
Factors Associated with Pneumocystis jirovecii Pneumonia in Patients with Rheumatoid Arthritis Receiving Methotrexate: A Single-center Retrospective Study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Retrospective Studies | 2022 |
Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Gene Expression Regulation; Genome-Wide Association Study; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Janus Kinase 1; Liver; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Young Adult | 2021 |
Common Transcriptomic Effects of Abatacept and Other DMARDs on Rheumatoid Arthritis Synovial Tissue.
Topics: Abatacept; Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gene Expression Profiling; Humans; Immunohistochemistry; Male; Methotrexate; Middle Aged; Rituximab; Signal Transduction; Synovial Membrane; Transcriptome | 2021 |
[Methotrexate treatment before use of biologics in rheumatoid arthritis : Analysis of guideline compliance].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Treatment Outcome | 2023 |
Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients With Rheumatoid Arthritis-Reply.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Symptom Flare Up | 2021 |
Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Symptom Flare Up | 2021 |
Prescribing Trends of Biologic Disease-Modifying Anti-rheumatic Drugs Using a Claims Database from 6 Million People in Japan.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Japan; Methotrexate | 2021 |
Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study.
Topics: Arthritis, Rheumatoid; Humans; Injections, Intra-Articular; Methotrexate; Synovial Fluid; Synovial Membrane | 2021 |
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12 | 2023 |
Sustained Long-Term Retention Rates of Abatacept in Combination with Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Elderly Patients with Rheumatoid Arthritis.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Tacrolimus; Treatment Outcome | 2021 |
In vitro evaluation of disease-modifying antirheumatic drugs against rheumatoid arthritis associated pathogens of the oral microflora.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Microbiota; Sulfasalazine | 2021 |
The effects of iguratimod combined with methotrexate and hydroxychloroquine on bone mineral density in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bone Density; Chromones; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Retrospective Studies; Sulfonamides | 2021 |
[Visceral leishmaniasis mimicking Felty's syndrome in rheumatoid arthritis treated with methotrexate and etanercept].
Topics: Arthritis, Rheumatoid; Etanercept; Felty Syndrome; Humans; Leishmaniasis, Visceral; Methotrexate; Tumor Necrosis Factor Inhibitors | 2022 |
Economic Benefit from Improvements in Quality of Life with Upadacitinib: Comparisons with Tofacitinib and Methotrexate in Patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Dr. Kremer et al reply.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2022 |
Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells.
Topics: Arthritis, Rheumatoid; Female; Folic Acid; Humans; Leucovorin; Methotrexate; Trophoblasts | 2022 |
[Development of classical Hodgkin lymphoma in a patient receiving tocilizumab for rheumatoid arthritis].
Topics: Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Bleomycin; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Methotrexate; Vinblastine | 2021 |
Neuropsychiatric adverse drug reactions associated with low dose methotrexate in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Quality of Life | 2022 |
Risk of venous thromboembolism associated with methotrexate versus hydroxychloroquine for rheumatoid arthritis: A propensity score-matched cohort study.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Hydroxychloroquine; Incidence; Male; Medicare; Methotrexate; Propensity Score; Pulmonary Embolism; Risk Factors; United States; Venous Thromboembolism | 2021 |
Search of official nationwide database in Japan for adverse events associated with disease-modifying antirheumatic drug therapies: focus on therapies in combination with methotrexate.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Japan; Methotrexate; Treatment Outcome | 2022 |
Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Down-Regulation; Fibroblasts; Gene Expression Regulation; Humans; Methotrexate; MicroRNAs; Synovial Membrane; Synoviocytes; Up-Regulation | 2021 |
Transdermal release of methotrexate by cationic starch/poly(vinyl alcohol)-based films as an approach for rheumatoid arthritis treatment.
Topics: Animals; Arthritis, Rheumatoid; Cations; Methotrexate; Mice; Polyvinyl Alcohol; Starch | 2022 |
Pregnancy outcomes in patients with rheumatoid arthritis who discontinue methotrexate treatment to conceive.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Pregnancy; Pregnancy Outcome; Sulfasalazine; Treatment Outcome | 2022 |
Programmable Polymeric Microneedles for Combined Chemotherapy and Antioxidative Treatment of Rheumatoid Arthritis.
Topics: 3T3 Cells; Administration, Cutaneous; Animals; Antioxidants; Arthritis, Rheumatoid; Drug Therapy, Combination; Indoles; Manganese Compounds; Methotrexate; Mice; Oxides; Particle Size; Polymers; RAW 264.7 Cells; Reactive Oxygen Species; Surface Properties | 2021 |
Microwave hyperthermia-responsible flexible liposomal gel as a novel transdermal delivery of methotrexate for enhanced rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Humans; Hyperthermia, Induced; Liposomes; Methotrexate; Microwaves | 2021 |
Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate; Prednisolone; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
The Macrophage Reprogramming Ability of Antifolates Reveals Soluble CD14 as a Potential Biomarker for Methotrexate Response in Rheumatoid Arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Cytokines; Female; Folic Acid Antagonists; Gene Expression Regulation; Humans; Inflammation Mediators; Lipopolysaccharide Receptors; Macrophages; Male; Methotrexate; Middle Aged; Pemetrexed; Prognosis; ROC Curve; Signal Transduction; Toll-Like Receptor 4; Transcriptome; Treatment Outcome | 2021 |
Disappearance of bulky diffuse large B-cell lymphoma after methotrexate/infliximab withdrawal.
Topics: Aged; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Treatment Outcome | 2022 |
PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; B7-H1 Antigen; Female; Hodgkin Disease; Humans; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Remission, Spontaneous | 2022 |
Use of biologic agents and methotrexate improves renal manifestation and outcome in patients with rheumatoid arthritis: a retrospective analysis.
Topics: Arthritis, Rheumatoid; Biological Factors; Humans; Kidney; Methotrexate; Renal Dialysis; Retrospective Studies | 2022 |
A Case of Thoracolithiasis Extracted with a Thoracoscope.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Male; Methotrexate; Thoracoscopes; Tomography, X-Ray Computed | 2021 |
Upadacitinib as monotherapy and in combination with non-biologic disease-modifying antirheumatic drugs for psoriatic arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Double-Blind Method; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Treatment Outcome | 2022 |
Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; CpG Islands; DNA Methylation; DNA-Binding Proteins; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Memory T Cells; Methotrexate; Middle Aged; Receptors, CCR6; Receptors, Cell Surface; STAT3 Transcription Factor; Synaptogyrins | 2021 |
Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Liver Diseases; Methotrexate | 2022 |
The development and validation of a Patient-Perceived Methotrexate Intolerance Scale for use in adult rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Humans; Methotrexate; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires | 2022 |
Risk of herpes zoster in patients with rheumatoid arthritis in the biologics era from 2011 to 2015 and its association with methotrexate, biologics, and corticosteroids.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Male; Methotrexate | 2022 |
Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis: A Pharmacogenomics-Driven Machine Learning Approach.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Machine Learning; Male; Methotrexate; Middle Aged; Pharmacogenetics; Severity of Illness Index; Treatment Outcome | 2022 |
Methotrexate-loaded folic acid of solid-phase synthesis conjugated gold nanoparticles targeted treatment for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Folic Acid; Gold; Metal Nanoparticles; Methotrexate; Mice; Nanoparticles; Rats; Solid-Phase Synthesis Techniques; Tissue Distribution | 2022 |
Clinical efficacy and safety of methotrexate compared with leflunomide in the treatment of rheumatoid arthritis: A protocol for systematic review and meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Leflunomide; Meta-Analysis as Topic; Methotrexate; Systematic Reviews as Topic; Treatment Outcome | 2021 |
Epstein-Barr virus encephalitis in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Encephalitis; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Methotrexate; Middle Aged | 2022 |
Simultaneous occurrence of accelerated nodulosis in lungs, liver, and kidneys, and acute exacerbation of interstitial pneumonia in a patient with rheumatoid arthritis: an autopsy case report.
Topics: Aged; Arthritis, Rheumatoid; Autopsy; Hand; Humans; Immunosuppressive Agents; Kidney; Liver; Lung; Lung Diseases, Interstitial; Male; Methotrexate; Methylprednisolone; Rheumatoid Nodule | 2022 |
Efficacy and safety of methotrexate in the treatment of rheumatoid arthritis: a retrospective study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2021 |
Functional coding haplotypes and machine-learning feature elimination identifies predictors of Methotrexate Response in Rheumatoid Arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Haplotypes; Humans; Machine Learning; Methotrexate; Polymorphism, Single Nucleotide | 2022 |
Can we predict unresponsiveness to methotrexate in rheumatoid arthritis? A pharmacogenetic study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Humans; Methotrexate; Pharmacogenomic Testing; Polymorphism, Single Nucleotide; Treatment Outcome | 2022 |
Disease-Modifying Antirheumatic Drugs and Risk of Parkinson Disease: Nested Case-Control Study of People With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Logistic Models; Male; Methotrexate; Parkinson Disease | 2022 |
Rates and predictors of methotrexate-related adverse events in patients with early rheumatoid arthritis: results from a nationwide UK study.
Topics: Alanine Transaminase; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Male; Methotrexate; Prospective Studies; Sheep; Treatment Outcome; United Kingdom | 2022 |
Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis.
Topics: Alcohol Drinking; Arthritis, Rheumatoid; Cohort Studies; Humans; Methotrexate; Myocardial Infarction; Risk Factors | 2022 |
Adherence of Italian rheumatologists to the EULAR recommendations and outcomes in early rheumatoid arthritis patients after starting conventional DMARDs: Methotrexate in Italian patients wiTh Rheumatoid Arthritis (the MITRA study). A cohort study of the I
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Humans; Methotrexate; Rheumatologists; Rheumatology; Treatment Outcome | 2022 |
Machine learning using genetic and clinical data identifies a signature that robustly predicts methotrexate response in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cohort Studies; Humans; Machine Learning; Methotrexate; Polymorphism, Single Nucleotide | 2022 |
Immunologic Parameters for Disease Activity in Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Humans; Methotrexate; Th17 Cells; Tumor Necrosis Factor Inhibitors | 2021 |
Rheumatoid arthritis caused by non-tuberculous mycobacteria infection.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Nontuberculous Mycobacteria; Synovitis; Tenosynovitis | 2023 |
Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Humans; Matrix Metalloproteinase 13; Methotrexate; Nanomedicine; Polymers; Rats; Tissue Distribution | 2022 |
Long-term outcome of patients with palindromic rheumatism treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infant; Methotrexate; Rheumatoid Factor; Treatment Outcome | 2022 |
Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; COVID-19 Vaccines; Drug Therapy, Combination; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Prospective Studies; SARS-CoV-2; Treatment Outcome; Vaccines, Inactivated | 2022 |
Selection of treatment regimens based on shared decision-making in patients with rheumatoid arthritis on remission in the FREE-J study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Decision Making, Shared; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2022 |
Co-treatment of Nimbolide augmented the anti-arthritic effects of methotrexate while protecting against organ toxicities.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Freund's Adjuvant; Limonins; Liver; Methotrexate; Protective Agents; Rats; Rats, Wistar | 2022 |
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dendritic Cells, Follicular; Humans; Lymphatic Diseases; Methotrexate; Thymus Hyperplasia | 2022 |
Early prediction of treatment response in rheumatoid arthritis by quantitative macrophage PET.
Topics: Arthritis, Rheumatoid; Female; Hand; Humans; Macrophages; Male; Methotrexate; Positron Emission Tomography Computed Tomography | 2022 |
Seasonal exacerbation of rheumatoid arthritis detected by big claims data analysis: A retrospective population study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Retrospective Studies; Seasons | 2023 |
Assessment of Rheumatoid Hand Function as a Characteristic Feature of Rheumatoid Arthritis in Patients Treated with Methotrexate or Methotrexate with Biological Agents with or without Deformation of Hands.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Female; Hand Strength; Humans; Methotrexate; Treatment Outcome | 2022 |
Baricitinib further enhances disease-modifying effects by uncoupling the link between disease activity and joint structural progression in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Purines; Pyrazoles; Sulfonamides; Treatment Outcome | 2022 |
Non-adherence to methotrexate was associated with high disease activity and poor health-related outcomes during a 4-year follow-up of rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Prospective Studies; Quality of Life; Severity of Illness Index; Treatment Outcome | 2022 |
The naturally occurring flavonoid nobiletin reverses methotrexate resistance via inhibition of P-glycoprotein synthesis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Fibroblasts; Flavones; Gene Expression; Humans; Methotrexate; Mice; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt | 2022 |
Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Complement Activation; Complement Membrane Attack Complex; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
Patient-reported outcomes and realistic clinical endpoints for JAK inhibitors in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Fatigue; Humans; Janus Kinase Inhibitors; Methotrexate; Patient Reported Outcome Measures; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Pneumonia and Meningoencephalitis Due to Varicella-zoster Virus Reinfection and Epstein-Barr Virus Reactivation in a Patient with Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 3, Human; Herpesvirus 4, Human; Humans; Liver Neoplasms; Lymphoproliferative Disorders; Meningoencephalitis; Methotrexate; Pneumonia; Reinfection; Valacyclovir | 2022 |
Persistently normal blood tests in patients taking methotrexate for RA or azathioprine for IBD: a retrospective cohort study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cohort Studies; Humans; Inflammatory Bowel Diseases; Methotrexate; Retrospective Studies | 2022 |
Ultrasound imaging tracking of mesenchymal stem cells intracellularly labeled with biosynthetic gas vesicles for treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methotrexate; Rats; Rats, Sprague-Dawley; Ultrasonography | 2022 |
Tapering subcutaneous methotrexate causes more disease flares compared with tapering oral administration in established rheumatoid arthritis patients.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Symptom Flare Up | 2022 |
Correlation between serum methotrexate-polyglutamate 3 (MTX-PG3) level and disease activity in rheumatoid arthritis patients: A prospective cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Humans; Methotrexate; Polyglutamic Acid; Prospective Studies | 2022 |
Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; beta-Glucans; Drug Carriers; Methotrexate; Nanoparticles; Saccharomyces cerevisiae | 2022 |
Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Tacrolimus; Treatment Outcome | 2023 |
Using FibroScan to Assess for the Development of Liver Fibrosis in Patients With Arthritis on Methotrexate: A Single-center Experience.
Topics: Arthritis, Rheumatoid; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Male; Methotrexate | 2022 |
Validation in the ESPOIR cohort of vitamin K-dependent protein S (PROS) as a potential biomarker capable of predicting response to the methotrexate/etanercept combination.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Protein S; Treatment Outcome | 2022 |
Pooled safety results across phase 3 randomized trials of intravenous golimumab in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
Topics: Administration, Intravenous; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Double-Blind Method; Humans; Male; Methotrexate; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing; Treatment Outcome | 2022 |
The beneficial effect of csDMARDs co-medication on drug persistence of first-line TNF inhibitor in rheumatoid arthritis patients: data from Czech ATTRA registry.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Czech Republic; Drug Therapy, Combination; Humans; Methotrexate; Registries; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Impact of Janus kinase inhibitors on antibody response to 13-valent pneumococcal conjugate vaccine in patients with rheumatoid arthritis.
Topics: Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoglobulin G; Janus Kinase Inhibitors; Methotrexate; Pneumococcal Vaccines; Vaccines, Conjugate | 2023 |
Pre-defined gene co-expression modules in rheumatoid arthritis transition towards molecular health following anti-TNF therapy.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Influence of concomitant methotrexate use on the clinical effectiveness, retention, and safety of abatacept in biologic-naïve patients with rheumatoid arthritis: Post-hoc subgroup analysis of the ORIGAMI study.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2023 |
In pediatric rheumatologic disease, methotrexate leads to mildly changed bloodwork on the second day after administration.
Topics: Arthritis, Rheumatoid; Child; Humans; Methotrexate; Rheumatic Diseases | 2022 |
Clinical characteristics and variants that predict prognosis of difficult-to-treat rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prognosis; Quality of Life; Treatment Outcome | 2022 |
Methotrexate significantly reduces the humoral vaccination response against SARS-CoV-2 in older but not younger patients with rheumatoid arthritis.
Topics: Aged; Antibodies, Neutralizing; Antibodies, Viral; Arthritis, Rheumatoid; COVID-19; Cross-Sectional Studies; Humans; Methotrexate; Middle Aged; SARS-CoV-2; Vaccination | 2022 |
A Study of Pulmonary Function Tests in Patients with Rheumatoid Arthritis and its Association with Disease Activity.
Topics: Adult; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Lung Diseases; Male; Methotrexate; Respiratory Function Tests; Severity of Illness Index | 2022 |
Exhaled nitric oxide in early rheumatoid arthritis and effects of methotrexate treatment.
Topics: Arthritis, Rheumatoid; Exhalation; Humans; Lung; Methotrexate; Nitric Oxide | 2022 |
Changes in treatment adherence and behaviour during the COVID-19 pandemic in Japanese patients with rheumatoid arthritis: Results from cross-sectional study in the IORRA cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; Cross-Sectional Studies; Humans; Japan; Methotrexate; Pandemics; Treatment Adherence and Compliance | 2022 |
Factors associated with frailty in rheumatoid arthritis patients with decreased renal function.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Kidney; Methotrexate; Research Design; Treatment Outcome | 2023 |
Multifunctional Nanoparticles Co-Loaded with Perfluoropropane, Indocyanine Green, and Methotrexate for Enhanced Multimodal Imaging of Collagen-Induced Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Fluorocarbons; Indocyanine Green; Methotrexate; Multifunctional Nanoparticles; Multimodal Imaging; Nanoparticles; Rats | 2022 |
Methotrexate promotes recovery of arthritis-induced alveolar bone loss and modifies the composition of the oral-gut microbiota.
Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Edema; Gastrointestinal Microbiome; Hyperalgesia; Methotrexate; Mice; Microbiota; RNA, Ribosomal, 16S; X-Ray Microtomography | 2022 |
Risk of severe COVID-19 in patients with inflammatory rheumatic diseases treated with immunosuppressive therapy in Scotland.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; COVID-19; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Methotrexate; Prednisolone; Rheumatic Diseases | 2023 |
Infectious risk of add-on leflunomide or tacrolimus versus TNF inhibitors among patients with rheumatoid arthritis receiving background methotrexate: A population-based cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Herpes Zoster; Humans; Infections; Leflunomide; Methotrexate; Tacrolimus; Tumor Necrosis Factor Inhibitors | 2022 |
Risk of malignant melanoma and non-melanoma skin cancer in rheumatoid arthritis patients initiating methotrexate versus hydroxychloroquine: a cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Humans; Hydroxychloroquine; Melanoma; Melanoma, Cutaneous Malignant; Methotrexate; Skin Neoplasms | 2023 |
Development of pH-sensitive dextran-based methotrexate nanodrug for rheumatoid arthritis therapy through inhibition of JAK-STAT pathways.
Topics: Animals; Arthritis, Rheumatoid; Dextrans; Hydrogen-Ion Concentration; Janus Kinases; Methotrexate; Nanoparticles; Rats; Signal Transduction; STAT Transcription Factors | 2022 |
High Efficacy Combined Microneedles Array with Methotrexate Nanocrystals for Effective Anti-Rheumatoid Arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Methotrexate; Nanoparticles; Pharmaceutical Preparations; Rats | 2022 |
Differential Impact of Biologic Therapy on Heart Function Biomarkers in Rheumatoid Arthritis Patients: Observational Study on Etanercept, Adalimumab, and Tocilizumab.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biological Therapy; Biomarkers; Etanercept; Fatty Acid Binding Protein 3; Heart Injuries; Humans; Methotrexate; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
A retrospective, longitudinal study of rheumatoid arthritis treatment patterns with Janus kinase inhibitors and other disease-modifying antirheumatic drugs in Japan.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunologic Factors; Janus Kinase Inhibitors; Japan; Longitudinal Studies; Methotrexate; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2023 |
Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell-Free Nucleic Acids; DNA; Inflammation; Matrix Metalloproteinase 2; Methotrexate; Rats | 2022 |
[A patient with rheumatoid arthritis who developed liver cirrhosis after increased soft drinks intake].
Topics: Arthritis, Rheumatoid; Carbonated Beverages; Female; Humans; Liver Cirrhosis; Methotrexate; Sugars | 2022 |
Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; IgA Vasculitis; Infliximab; Methotrexate; Nephritis; Proteinuria; Purpura | 2023 |
Glycolysis aggravates methotrexate toxicity by fueling RFC1-controlled intestinal absorption in rheumatic rats.
Topics: Adenosine Triphosphate; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Glycolysis; Humans; Intestinal Absorption; Methotrexate; Rats | 2022 |
Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Biomimetics; Folic Acid; Humans; Metal-Organic Frameworks; Methotrexate; Nanoparticles; Tissue Distribution | 2022 |
Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Collagen; Humans; Inflammation; Macrophages; Methotrexate; Mice; Neuropilin-2; Semaphorins; Synovial Membrane | 2022 |
Adalimumab or etanercept as first line biologic therapy in enthesitis related arthritis (ERA) - a drug-survival single centre study spanning 10 years.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Biological Therapy; Biosimilar Pharmaceuticals; Etanercept; Humans; Infliximab; Methotrexate; Treatment Outcome | 2022 |
Core-shell Pluronic F127/chitosan based nanoparticles for effective delivery of methotrexate in the management of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Methotrexate; Nanoparticles; Particle Size; Poloxamer; Polymers; Rats | 2022 |
Efficacy of leflunomide in the treatment of palindromic rheumatism.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Leflunomide; Methotrexate; Prednisolone; Retrospective Studies; Treatment Outcome | 2022 |
Impact of Methotrexate Discontinuation, Interruption, or Persistence in US Patients with Rheumatoid Arthritis Initiating Tofacitinib + Oral Methotrexate Combination.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Studies as Topic; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Retrospective Studies; Treatment Outcome | 2022 |
Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats.
Topics: Alanine; Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Aspartate Aminotransferases; C-Reactive Protein; Catalase; Creatinine; Cyclohexenes; Cyclooxygenase 2; Freund's Adjuvant; Glutathione; Glutathione Peroxidase; Interleukin-6; Malondialdehyde; Methotrexate; NF-kappa B; Rats; Terpenes; Tumor Necrosis Factor-alpha; Urea | 2022 |
Unincreased risk of hospitalized infection under targeted therapies versus methotrexate in elderly patients with rheumatoid arthritis: a retrospective cohort study.
Topics: Adolescent; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2022 |
Magnetic resonance imaging of methotrexate-related lymphoproliferative disorder with a chief complaint of oral symptoms.
Topics: Arthritis, Rheumatoid; Diffusion Magnetic Resonance Imaging; Humans; Lymphoproliferative Disorders; Magnetic Resonance Imaging; Methotrexate | 2023 |
Iguratimod versus salazosulfapyridine in rheumatoid arthritis patients with an inadequate response to methotrexate: Adjusted with propensity score matching.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Propensity Score; Retrospective Studies; Sulfasalazine; Treatment Outcome | 2023 |
Impaired adrenal cortex reserve in patients with rheumatic and musculoskeletal diseases who relapse upon tapering of low glucocorticoid dose.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Insufficiency; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Cosyntropin; Glucocorticoids; Humans; Hydrocortisone; Hydroxychloroquine; Leflunomide; Methotrexate; Prednisolone; Recurrence; Tumor Necrosis Factor Inhibitors | 2022 |
Improvement in patient-reported outcomes in rheumatoid arthritis patients treated with sarilumab is independent of the cognition levels.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cognition; Humans; Methotrexate; Patient Reported Outcome Measures; Treatment Outcome | 2022 |
Impact of pre-existing background therapy on placebo responses in randomised controlled clinical trials of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Placebo Effect; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Development and external validation of prediction models for adverse health outcomes in rheumatoid arthritis: A multinational real-world cohort analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Humans; Methotrexate; Outcome Assessment, Health Care; Stroke | 2022 |
Can we finally exonerate methotrexate as a factor in causing or exacerbating fibrotic interstitial lung disease in patients with rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Methotrexate | 2022 |
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Humans; Joints; Methotrexate; Rats; Synovial Membrane; Synoviocytes | 2023 |
Real-world data on seropositive rheumatoid arthritis, then and now: ten-year outcomes of 1151 patients diagnosed between 1997 and 2011.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pain; Severity of Illness Index; Treatment Outcome | 2023 |
Predictors of Treatment Change Among Patients with Rheumatoid Arthritis Treated with TNF Inhibitors as First-Line Biologic Agent in the USA: A Cohort Study from Longitudinal Electronic Health Records.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Electronic Health Records; Female; Glucocorticoids; Humans; Inflammatory Bowel Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Vitamin D | 2022 |
Cardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Hydroxychloroquine; Medicare; Methotrexate; Myocardial Infarction; Risk Factors; United States | 2022 |
Bilateral Stress Fractures of the Lower Extremity in Methotrexate Osteopathy.
Topics: Arthritis, Rheumatoid; Bone Diseases; Fractures, Bone; Fractures, Stress; Humans; Lower Extremity; Methotrexate | 2022 |
Plasma metabolomic profiling as a tool to identify predictive biomarkers of methotrexate efficacy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Diffuse Large B-cell Lymphoma with Adrenal Involvement Presenting as Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorders: Sustained Remission with Methotrexate Termination Alone in Two Cases.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Iatrogenic Disease; Immunologic Deficiency Syndromes; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Neoplasm Recurrence, Local | 2023 |
Evaluating the effect of methotrexate on the rate of renal fibrosis by elastography and fibrosis-related gene expression.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Elasticity Imaging Techniques; Fibrosis; Gene Expression; Humans; Kidney Diseases; Liver Cirrhosis; Methotrexate; Transforming Growth Factor beta | 2022 |
Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Gene Regulatory Networks; Humans; Methotrexate; Sequence Analysis, RNA | 2022 |
Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Malaysia; Metabolic Networks and Pathways; Methotrexate; Polymorphism, Single Nucleotide | 2022 |
Effectiveness and Safety of Golimumab for Patients ≥75 Years Old with Rheumatoid Arthritis.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
[Disseminated Skin Ulcers Associated with Methotrexate].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Skin; Skin Ulcer | 2023 |
Effects of anti-SSA antibodies on the response to methotrexate in rheumatoid arthritis: A retrospective multicenter observational study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2022 |
Discontinuing methotrexate to enhance vaccine response.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Vaccines | 2022 |
Outcomes and risk factors for mortality in Pneumocystis pneumonia patients with rheumatoid arthritis: A multicentre retrospective cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Methotrexate; Pneumonia, Pneumocystis; Retrospective Studies; Risk Factors | 2023 |
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Methotrexate Treatment Suppresses Monocytes in Nonresponders to Pneumococcal Conjugate Vaccine in Rheumatoid Arthritis Patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Monocytes; Pneumococcal Vaccines; Vaccines, Conjugate | 2022 |
Concerted regulation of OPG/RANKL/ NF‑κB/MMP-13 trajectories contribute to ameliorative capability of prodigiosin and/or low dose γ-radiation against adjuvant- induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Interleukin-10; Interleukin-17; Interleukin-18; Interleukin-6; Matrix Metalloproteinase 13; Methotrexate; NF-kappa B; Prodigiosin; Rats; Tumor Necrosis Factor-alpha | 2022 |
Specific enterotype of gut microbiota predicted clinical effect of methotrexate in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; China; Cytokines; Gastrointestinal Microbiome; Humans; Methotrexate; RNA, Ribosomal, 16S | 2023 |
Impacts of Low-Dose Total Glycosides of Tripterygium wilfordii plus Methotrexate on Immunological Function and Inflammation Level in Patients with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Glycosides; Humans; Inflammation; Methotrexate; Treatment Outcome; Tripterygium | 2022 |
Add-on effectiveness of methotrexate or iguratimod in patients with rheumatoid arthritis exhibiting an inadequate response to Janus kinase inhibitors: The ANSWER cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfonamides; Treatment Outcome | 2023 |
Janus kinase (JAK) inhibitors significantly reduce the humoral vaccination response against SARS-CoV-2 in patients with rheumatoid arthritis.
Topics: Antibodies, Neutralizing; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; Cross-Sectional Studies; Humans; Janus Kinase Inhibitors; Janus Kinases; Methotrexate; SARS-CoV-2; Vaccination | 2022 |
Long-term safety and efficacy of methotrexate in patients with palindromic rheumatism.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Rheumatic Diseases | 2022 |
Two birds with one stone: Successful treatment with methotrexate in a patient with generalized eruptive keratoacanthoma of Grzybowski and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Keratoacanthoma; Methotrexate | 2022 |
Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Retrospective Studies; Syndrome | 2022 |
Hydroxychloroquine and Risk of Long QT Syndrome in Rheumatoid Arthritis: A Veterans Cohort Study With Nineteen-Year Follow-up.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Long QT Syndrome; Male; Methotrexate; Middle Aged; Retrospective Studies; Veterans | 2023 |
Effect of Janus kinase inhibitors on T cell responses to herpes zoster in rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cytokines; Granzymes; Herpes Zoster; Herpesvirus 3, Human; Humans; Janus Kinase Inhibitors; Leukocytes, Mononuclear; Methotrexate | 2023 |
Case Report: Cutaneous Leishmaniasis in a Rheumatoid Arthritis Patient Receiving Methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Leishmania infantum; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Methotrexate | 2022 |
Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Inflammation; Methotrexate; Pharmacogenetics | 2022 |
Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Genome-Wide Association Study; Humans; Liver; Male; Methotrexate | 2022 |
OAT3 mediates methotrexate resistance in the treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Hyperplasia; Methotrexate; Rats; Synovial Membrane | 2022 |
Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Macrophages; Methotrexate | 2022 |
FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Fluorodeoxyglucose F18; Humans; Lymphoproliferative Disorders; Methotrexate; Positron Emission Tomography Computed Tomography | 2022 |
Different humoral but similar cellular responses of patients with autoimmune inflammatory rheumatic diseases under disease-modifying antirheumatic drugs after COVID-19 vaccination.
Topics: Antibodies, Neutralizing; Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; COVID-19 Vaccines; Female; Humans; Immunoglobulin G; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; SARS-CoV-2; Vaccination | 2022 |
Rheumatoid arthritis in a transman: A new case.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Drug Therapy, Combination; Female; Humans; Mastectomy; Methotrexate; Treatment Outcome | 2022 |
Comparing the effectiveness and safety of Abatacept and Tocilizumab in elderly patients with rheumatoid arthritis.
Topics: Abatacept; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate; Treatment Outcome | 2022 |
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Rheumatic Diseases | 2022 |
Frequency and Pattern of Rheumatoid Arthritis in a Tertiary Hospital in Maiduguri, North-Eastern Nigeria.
Topics: Arthritis, Rheumatoid; Biological Products; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Muscular Diseases; Nigeria; Retrospective Studies; Rheumatoid Factor; Tertiary Care Centers; United States | 2022 |
Examining the potential direct cardiovascular benefit of tumor-necrosis factor inhibitor in rheumatoid arthritis: Natural and controlled direct effect analyses.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Necrosis; Neoplasms; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Post-switch Effectiveness of Etanercept Biosimilar Versus Continued Etanercept in Rheumatoid Arthritis Patients with Stable Disease: A Prospective Multinational Observational Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Etanercept; Humans; Methotrexate; Prospective Studies; Treatment Outcome | 2022 |
Septic arthritis induced by Streptococcus pneumoniae occurring in rheumatoid arthritis treated with abatacept and methotrexate: A case report.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Streptococcus pneumoniae | 2023 |
Case report: Joint deformity associated with systemic lupus erythematosus.
Topics: Adult; Antibodies, Antinuclear; Antigens, Nuclear; Arthritis, Rheumatoid; C-Reactive Protein; Celecoxib; Complement C3; DNA; Female; Humans; Lupus Erythematosus, Systemic; Methotrexate; Prednisone | 2022 |
Hyaluronic acid-coated solid lipid nanoparticles enhance antirheumatic activity and reduce toxicity of methotrexate.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Freund's Adjuvant; Hyaluronic Acid; Methotrexate; Rats | 2022 |
Optimizing methotrexate withdrawal during COVID vaccination.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; COVID-19; Humans; Methotrexate; Vaccination | 2022 |
Early characterization of difficult-to-treat rheumatoid arthritis by suboptimal initial management: a multicentre cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Glucocorticoids; Humans; Methotrexate; Treatment Outcome | 2023 |
Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Ketoglutaric Acids; Methotrexate; Mice; Mice, Inbred DBA; Nanoparticles; Polymers; T-Lymphocytes, Helper-Inducer | 2022 |
Role of Ondansetron in Reducing Methotrexate Intolerance in Patients with Inflammatory Arthritis.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Humans; Methotrexate; Nausea; Ondansetron; Treatment Outcome; Vomiting | 2022 |
[Re-recognition of methotrexate monotherapy in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2022 |
Porous Silicon-Based Nanomedicine for Simultaneous Management of Joint Inflammation and Bone Erosion in Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Drug Carriers; Inflammation; Methotrexate; Mice; Nanomedicine; Porosity; Silicon | 2022 |
Reduced humoral response to a third dose (booster) of SARS-CoV-2 mRNA vaccines by concomitant methotrexate therapy in elderly patients with rheumatoid arthritis.
Topics: Aged; Antibodies, Viral; Arthritis, Rheumatoid; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Humans; Immunity, Humoral; Immunoglobulin G; Methotrexate; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2022 |
Rheumatoid arthritis and Hailey-Hailey disease treated with methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Methotrexate; Pemphigus, Benign Familial; Quality of Life | 2023 |
Use of a bDMARD or tsDMARD for the management of inflammatory arthritis under checkpoint inhibitors: an observational study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immune Checkpoint Inhibitors; Interleukin 1 Receptor Antagonist Protein; Janus Kinase Inhibitors; Male; Methotrexate; Retrospective Studies; Tumor Necrosis Factor Inhibitors; Ustekinumab | 2022 |
Methotrexate improves endothelial function in early rheumatoid arthritis patients after 3 months of treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD28 Antigens; Endothelium; Humans; Methotrexate; Vascular Cell Adhesion Molecule-1 | 2022 |
Associations Between microRNA-related Genetic Polymorphisms and Clinical Response to Methotrexate in Chinese Rheumatoid Arthritis Patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; China; Female; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Polymorphism, Genetic | 2022 |
[Difficult-to-treat rheumatoid arthritis in real clinical practice. Preliminary results].
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Middle Aged; Quality of Life; Rituximab | 2022 |
Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Catalase; Drug Therapy, Combination; Inflammation; Interleukin-17; Matrix Metalloproteinase 9; Methotrexate; Oxidative Stress; Rats; RNA, Messenger | 2022 |
[Effect of methotrexate on the urinary proteome of rats].
Topics: Animals; Arthritis, Rheumatoid; Chromatography, Liquid; Methotrexate; Proteome; Rats; Tandem Mass Spectrometry | 2022 |
Accelerated rheumatoid nodulosis resolved after switching to Janus kinase inhibitor therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Methotrexate; Rheumatoid Nodule | 2023 |
Red Cell Distribution Width and Absolute Lymphocyte Count Associate With Biomarkers of Inflammation and Subsequent Mortality in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Erythrocyte Indices; Humans; Inflammation; Lymphocyte Count; Methotrexate; Retrospective Studies | 2023 |
Response to Dr Urata's Letter to the Editor of Modern Rheumatology regarding a study of "Treatment of rheumatoid arthritis after regression of lymphoproliferative disorders".
Topics: Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Rheumatology | 2023 |
Efficacy of sulfasalazine for the prevention of Pneumocystis pneumonia in patients with rheumatoid arthritis: A multicentric self-controlled case series study.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Retrospective Studies; Sulfasalazine | 2023 |
In situ Preparation of a Phospholipid Gel Co-Loaded with Methotrexate and Dexamethasone for Synergistic Rheumatoid Arthritis Treatment.
Topics: Animals; Arthritis, Rheumatoid; Dexamethasone; Gels; Injections, Intra-Articular; Methotrexate; Phospholipids; Rabbits; Tumor Necrosis Factor-alpha | 2022 |
Treatment of rheumatoid arthritis after regression of lymphoproliferative disorders in patients treated with methotrexate: A retrospective, multi-center descriptive study: Comment on the article by Nakano K et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Retrospective Studies; Rheumatology | 2023 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms | 2023 |
Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients.
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Leukocytes, Mononuclear; Long Interspersed Nucleotide Elements; Methotrexate; Methylation; Prospective Studies; Treatment Outcome | 2022 |
CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cattle; Cytokines; Janus Kinase Inhibitors; Male; Methotrexate; Rats; Rats, Sprague-Dawley | 2022 |
Treatment Response to Tumor Necrosis Factor Inhibitors and Methotrexate Monotherapy in Adults With Juvenile Idiopathic Arthritis: Data From NOR-DMARD.
Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Methotrexate, leflunomide and tacrolimus use and the progression of rheumatoid arthritis-associated interstitial lung disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Tacrolimus | 2023 |
Baseline bony erosions and time-averaged DAS28 predict discontinuation of TNF inhibitors in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2022 |
Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Prospective Studies | 2022 |
Disproportionate articular pain is a frequent phenomenon in rheumatoid arthritis and responds to treatment with sarilumab.
Topics: Adalimumab; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Humans; Interleukin-6; Methotrexate; Treatment Outcome | 2023 |
Machine learning identifies a profile of inadequate responder to methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2023 |
Rituximab Monotherapy for Grade 2-3 Lymphomatoid Granulomatosis with Central Nervous System Involvement in a Patient Receiving Methotrexate for Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Brain; Humans; Lymphomatoid Granulomatosis; Methotrexate; Rituximab | 2023 |
Is the treatment of inflammatory arthritis different in sickle cell disease?
Topics: Anemia, Sickle Cell; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Retrospective Studies; Rheumatic Diseases; Tumor Necrosis Factor Inhibitors | 2022 |
Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients-case series.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Leflunomide; Methotrexate; Retrospective Studies; Tumor Necrosis Factor Inhibitors | 2022 |
What do patients on methotrexate need and expect at the clinic? An online patient survey.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Rheumatologists; Surveys and Questionnaires; Treatment Outcome | 2023 |
Primary hepatic methotrexate-associated lymphoproliferative disorder associated with Epstein-Barr virus reactivation and accompanied by spontaneous necrosis: A case report.
Topics: Antigens, CD; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Liver; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Necrosis | 2022 |
[Effect of moxibustion on AMPK/ULK1 signaling pathway in synovium tissue of toes in rats with rheumatoid arthritis].
Topics: Adenosine Monophosphate; AMP-Activated Protein Kinases; Animals; Arthritis, Rheumatoid; Autophagy-Related Protein-1 Homolog; Methotrexate; Moxibustion; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sirolimus; Synovial Membrane; Toes | 2022 |
Serum proteomics analysis of biomarkers for evaluating clinical response to MTX/IGU therapy in early rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Blood Proteins; Drug Therapy, Combination; Humans; Methotrexate; Proteomics; Treatment Outcome | 2023 |
[Lymphadenitis possibly due to human herpesvirus 7 during methotrexate therapy for rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Herpesvirus 7, Human; Humans; Methotrexate | 2022 |
Methotrexate conjugated gold nanoparticles improve rheumatoid vascular dysfunction in rat adjuvant-induced arthritis: gold revival.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Gold; Inflammation; Metal Nanoparticles; Methotrexate; Rats | 2023 |
Inflammation specific environment activated methotrexate-loaded nanomedicine to treat rheumatoid arthritis by immune environment reconstruction.
Topics: Arthritis, Rheumatoid; Cytokines; Humans; Inflammation; Methotrexate; Nanomedicine | 2023 |
Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Methotrexate; Needles; Rats; Transdermal Patch | 2023 |
Clinicopathological findings, prognosis, and Epstein-Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders.
Topics: Arthritis, Rheumatoid; Disease Progression; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Iatrogenic Disease; Killer Cells, Natural; Lymphoproliferative Disorders; Methotrexate; Prognosis; Tumor Suppressor Protein p53 | 2022 |
Comorbidities and treatment patterns in early rheumatoid arthritis: a nationwide Swedish study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Humans; Methotrexate; Renal Insufficiency, Chronic; Sweden | 2022 |
A case of extrapulmonary tuberculosis after use of baricitinib.
Topics: Arthritis, Rheumatoid; Azetidines; Female; Humans; Methotrexate; Middle Aged; Tuberculosis, Extrapulmonary | 2023 |
Case report: JAKi and TNFi dual therapy is a potential treatment strategy for difficult-to-treat rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2022 |
Simiao Yong'an decoction ameliorates murine collagen-induced arthritis by modulating neutrophil activities: An in vitro and in vivo study.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Methotrexate; Mice; Mice, Inbred DBA; Neutrophils; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2023 |
Impact of rheumatoid arthritis and methotrexate on pregnancy outcomes: retrospective cohort study of the Italian Society for Rheumatology.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pregnancy; Pregnancy Outcome; Retrospective Studies; Rheumatology | 2022 |
Lung Damage in Rheumatoid Arthritis-A Retrospective Study.
Topics: Arthritis, Rheumatoid; Bronchiectasis; Emphysema; Female; Fibrosis; Humans; Lung; Lung Diseases, Interstitial; Male; Methotrexate; Retrospective Studies; Rheumatoid Factor | 2022 |
Enhanced Anti-Inflammatory Effect of the Combination of
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Methotrexate; Rats | 2022 |
Deep eutectic solvents-Hydrogels for the topical management of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Deep Eutectic Solvents; Humans; Hydrogels; Methotrexate; Nanoparticles; Silicon Dioxide | 2023 |
Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Liver Cirrhosis; Longitudinal Studies; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies | 2023 |
Hepatic failure in a patient with rheumatoid arthritis treated with methotrexate: A case report.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Female; Humans; Liver Failure; Methotrexate; Non-alcoholic Fatty Liver Disease | 2023 |
Five-year cardiovascular event risk in early rheumatoid arthritis patients who received treat-to-target management: a case-control study.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Humans; Inflammation; Methotrexate; Risk Factors | 2023 |
Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.
Topics: Adaptor Proteins, Signal Transducing; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Genome-Wide Association Study; Humans; Methotrexate; Polymorphism, Single Nucleotide | 2023 |
Identification of Cell-Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; DNA; DNA Methylation; Humans; Methotrexate; Treatment Outcome | 2023 |
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Macrophages; Methotrexate; Mice; Phospholipids | 2023 |
Long-term safety and efficacy of sarilumab with or without background csDMARDs in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Neutropenia; Treatment Outcome | 2023 |
Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Humans; Macrophages; Mannose; Methotrexate; Quality of Life | 2023 |
[Must folic acid and folinic acid be substituted in methotrexate treatment? If yes, how much?]
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 2023 |
Risk of infection from glucocorticoid and methotrexate interaction in patients with rheumatoid arthritis using biologics: A retrospective cohort study.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Biological Factors; Biological Products; Glucocorticoids; Humans; Methotrexate; Middle Aged; Retrospective Studies | 2023 |
A Woman With Progressive Dyspnea and Seronegative Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Dyspnea; Female; Humans; Lung; Methotrexate | 2023 |
High-sensitivity cardiac troponin T is associated with disease activity in patients with inflammatory arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Troponin T; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
A rare side effect of methotrexate therapy: drug-induced osteopathy with multiple fractures of the lower limb.
Topics: Arthritis, Rheumatoid; Fractures, Multiple; Fractures, Stress; Humans; Lower Extremity; Methotrexate; Osteoporotic Fractures | 2023 |
Effect of prednisolone and saireito co-administration on T-cells of rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Interleukin-6; Leukocytes, Mononuclear; Methotrexate; Prednisolone | 2023 |
Suppression of Macrophage Activation by Sodium Danshensu via HIF-1α/STAT3/NLRP3 Pathway Ameliorated Collagen-Induced Arthritis in Mice.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophage Activation; Methotrexate; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Synovial Membrane | 2023 |
Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate.
Topics: Arthritis, Rheumatoid; Diphosphonates; Humans; Methotrexate; Osteonecrosis; Osteoporosis | 2023 |
Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Hydrogels; Methotrexate; Quality of Life; Rats | 2023 |
Tofacitinib for the treatment of inflammatory bowel disease-associated arthritis: two case reports.
Topics: Adult; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases; Male; Methotrexate; Middle Aged; Sulfasalazine | 2023 |
Transcriptomic profile comparison of monocytes from rheumatoid arthritis patients in treatment with methotrexate, anti-TNFa, abatacept or tocilizumab.
Topics: Abatacept; Arthritis, Rheumatoid; Humans; Methotrexate; Monocytes; Transcriptome; Tumor Necrosis Factor Inhibitors | 2023 |
Frequency of Helicobacter pylori in Patients With Rheumatoid Arthritis Whose Methotrexate Was Stopped Due to Gastrointestinal Intolerance.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Helicobacter pylori; Humans; Methotrexate; Treatment Outcome | 2023 |
[Methotrexate to prevent progression to rheumatoid arthritis?]
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Humans; Methotrexate | 2023 |
Methotrexate in pregnancy: still many unanswered questions.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pregnancy | 2023 |
Clinical characteristics of rheumatoid arthritis patients with interstitial lung disease: baseline data of a single-center prospective cohort.
Topics: Aged; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prospective Studies | 2023 |
Long-term persistence of oral methotrexate and associated factors in rheumatoid arthritis: a retrospective cohort study.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2023 |
Characteristics of patients with difficult-to-treat rheumatoid arthritis in a French single-centre hospital.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Lung Diseases, Interstitial; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Inflammation; Methotrexate; Mice; Vaccines | 2023 |
Discontinuation of Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis and Excellent Disease Control.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome; Withholding Treatment | 2023 |
[Methotrexate-related lymphoproliferative disease showing different histological findings at recurrence].
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Neoplasm Recurrence, Local | 2023 |
Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Feasibility Studies; Humans; Methotrexate; Treatment Outcome | 2023 |
A case of chronic eosinophilic pneumonia associated with rheumatoid arthritis in glucocorticoid-free remission with JAK inhibitor: A case report.
Topics: Adult; Arthritis, Rheumatoid; Asthma; Female; Glucocorticoids; Humans; Janus Kinase Inhibitors; Methotrexate; Middle Aged; Prednisolone; Pulmonary Eosinophilia; Recurrence; Young Adult | 2023 |
Case report: crowned dens syndrome in a patient with seronegative rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Humans; Methotrexate; Naproxen; Neck Pain; Syndrome | 2023 |
Comparative safety and effectiveness of TNF inhibitors, IL6 inhibitors and methotrexate for the treatment of immune checkpoint inhibitor-associated arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Immune Checkpoint Inhibitors; Interleukin-6 Inhibitors; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
A 54-Year-Old Woman With Rheumatoid Arthritis, Low-Grade Fever, and Cough.
Topics: Arthritis, Rheumatoid; Cough; Diagnosis, Differential; Dyspnea; Female; Fever; Hemoptysis; Humans; Methotrexate; Middle Aged | 2023 |
Epstein-Barr virus-positive CD30+ B-cell lymphoproliferative disease with histologic features resembling grade III lymphomatoid granulomatosis induced by methotrexate.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Ki-1 Antigen; Lymphomatoid Granulomatosis; Lymphoproliferative Disorders; Methotrexate | 2023 |
Efficacy and pharmacokinetics of ozoralizumab, an anti-TNFα NANOBODY
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2023 |
Risk factors associated with relapse after methotrexate dose reduction in patients with rheumatoid arthritis receiving golimumab and methotrexate combination therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Drug Tapering; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult | 2023 |
Comparative effectiveness of TNF inhibitor vs IL-6 receptor inhibitor as monotherapy or combination therapy with methotrexate in biologic-experienced patients with rheumatoid arthritis: An analysis from the CorEvitas RA Registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Receptors, Interleukin-6; Registries; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Fractionated whole body γ-irradiation aggravates arthritic severity via boosting NLRP3 and RANKL expression in adjuvant-induced arthritis model: the mitigative potential of ebselen.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Methotrexate; NLR Family, Pyrin Domain-Containing 3 Protein; RANK Ligand; Rats | 2023 |
Transdermal Delivery of Methotrexate Loaded in Chitosan Nanoparticles to Treat Rheumatoid Arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Chitosan; Cytokines; Humans; Methotrexate; Nanoparticles; Rats | 2024 |
Adherence to treatment and associated factors in rheumatoid arthritis patients: a cross-sectional study from Iran.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Iran; Male; Medication Adherence; Methotrexate | 2023 |
Methotrexate treatment in early psoriatic arthritis in comparison to rheumatoid arthritis: an observational nationwide study.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Methotrexate; Pain | 2023 |
Macrophage activation syndrome triggered by methotrexate-related lymphoproliferative disease in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Macrophage Activation Syndrome; Methotrexate; Middle Aged | 2023 |
Relationship between frailty and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Frailty; Humans; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2023 |
TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Forkhead Transcription Factors; Humans; Methotrexate; Mice; Th17 Cells | 2023 |
Association of hemoglobin levels with radiographic progression in patients with rheumatoid arthritis: an analysis from the BRASS registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Hemoglobins; Humans; Methotrexate; Registries | 2023 |
EBV-positive mucocutaneous ulcer arising in methotrexate-treated rheumatoid arthritis patients: a clinicopathological study of 12 cases with analysis of PD-L1 expression.
Topics: Arthritis, Rheumatoid; B7-H1 Antigen; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Methotrexate; Ulcer | 2023 |
Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx.
Topics: Aconitum; Arthritis, Rheumatoid; Inflammation; Methotrexate; Polysaccharides | 2023 |
Does methotrexate use increase the risk of dementia in patients with rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dementia; Humans; Methotrexate | 2023 |
Tofacitinib may improve insulin resistance in patients with rheumatoid arthritis and diabetes, implications for disease management and precision medicine approach.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus; Disease Management; Humans; Insulin Resistance; Methotrexate; Precision Medicine; Treatment Outcome | 2023 |
Calcium Folate for Reducing the Side Effects of Low-dose Methotrexate in Rheumatoid Arthritis: A Case Report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Folic Acid; Humans; Leucovorin; Male; Methotrexate | 2024 |
Network pharmacology analysis of the pharmacological mechanism of Artemisia lavandulaefolia DC. in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; China; Cytokines; Ethnicity; Fibroblasts; Humans; Methotrexate; Molecular Docking Simulation; Network Pharmacology | 2023 |
Cynanchum komarovii extract for the treatment of rheumatoid arthritis by acting on synovial cells in vitro and in vivo.
Topics: Animals; Apoptosis Regulatory Proteins; Arthritis, Experimental; Arthritis, Rheumatoid; Cynanchum; Humans; Methotrexate; Rats; Synovial Membrane; Synoviocytes | 2023 |
Rheumatoid meningitis: a rare neurological complication of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Humans; Meningitis; Methotrexate; Retrospective Studies | 2023 |
Methotrexate also improves rheumatoid arthritis through correction of microbiota dysbiosis.
Topics: Arthritis, Rheumatoid; Dysbiosis; Humans; Methotrexate; Microbiota | 2023 |
Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Retrospective Studies; Tacrolimus | 2023 |
Correlation between Cumulative Methotrexate Dose, Metabolic Syndrome and Hepatic Fibrosis Detected by FibroScan in Rheumatoid Arthritis Patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Elasticity Imaging Techniques; Humans; Insulin Resistance; Liver Cirrhosis; Metabolic Syndrome; Methotrexate | 2023 |
Methotrexate delivering microneedle patches for improved therapeutic efficacy in treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Guinea Pigs; Inflammation; Methotrexate | 2023 |
The effective threshold dose of etanercept in patients with methotrexate-resistant rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Severity of Illness Index; Treatment Outcome | 2023 |
Prediction of flare following glucocorticoids withdrawal in rheumatoid arthritis patients with continuation of csDMARDs: a real-life study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate; Prednisolone; Treatment Outcome | 2023 |
Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chitosan; Clove Oil; Drug-Related Side Effects and Adverse Reactions; Leflunomide; Methotrexate; Rats; Surface-Active Agents; Tumor Necrosis Factor-alpha | 2023 |
Disease-modifying anti-rheumatic drugs associated with different diabetes risks in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Diabetes Mellitus; Humans; Methotrexate | 2023 |
Comparison of subcutaneous and oral methotrexate initiation in rheumatoid arthritis in current practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate | 2023 |
Retrospective analysis and preliminary laboratory validation of treatment efficacy and blood lipid levels in patients with rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cholesterol, HDL; Humans; Lipids; Lipoproteins, HDL; Methotrexate; Mice; Retrospective Studies; Treatment Outcome | 2023 |
Methotrexate is associated with decreased total thyroxine in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cross-Sectional Studies; Glucocorticoids; Humans; Methotrexate; Thyroxine | 2023 |
An MMP-2 Responsive Nanotheranostic Probe Enabled Synergistic Therapy of Rheumatoid Arthritis and MR/CT Assessment of Therapeutic Response In Situ.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Matrix Metalloproteinase 2; Methotrexate; Mice; Theranostic Nanomedicine; Tomography, X-Ray Computed | 2023 |
Methotrexate-associated lymphoproliferative disorder in the thyroid gland of a patient with chronic thyroiditis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Thyroid Gland | 2023 |
Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Methotrexate; Nanoparticles | 2023 |
Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Animals; Arthritis, Rheumatoid; Fibroblasts; Hexokinase; Methotrexate; Mice; Synoviocytes; Synovitis | 2023 |
Magnetic resonance imaging RAMRIS-SAFE score-A low-risk effective measure of rapid response to therapy in rheumatoid arthritis clinical trials.
Topics: Adult; Aged; Arthritis, Rheumatoid; Edema; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Synovitis; Wrist Joint; Young Adult | 2023 |
To treat or not to treat? Current attitudes on treatment aimed at modifying the disease burden in clinically suspect arthralgia: a survey among participants of the TREAT EARLIER trial and healthcare professionals.
Topics: Arthralgia; Arthritis, Rheumatoid; Attitude; Clinical Trials as Topic; Cost of Illness; Delivery of Health Care; Humans; Methotrexate | 2023 |
A sensitive LC-MS/MS methotrexate assay capable of assessing adherence to methotrexate therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chromatography, Liquid; Humans; Methotrexate; Plasma; Reproducibility of Results; Tandem Mass Spectrometry | 2024 |
Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Cross-Sectional Studies; Humans; Inflammation; Liver Diseases; Longitudinal Studies; Methotrexate; Mice; Obesity; Peptides, Cyclic | 2023 |
Multifunctional nanoparticles encapsulating methotrexate and curcumin for holistic management of rheumatoid arthritis:
Topics: Arthritis, Rheumatoid; Curcumin; Drug Carriers; Humans; Methotrexate; Multifunctional Nanoparticles; Nanoparticles; Particle Size; Serum Albumin, Bovine | 2023 |
Development of prediction model for alanine transaminase elevations during the first 6 months of conventional synthetic DMARD treatment.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Outcome | 2023 |
Real-World Data of Adherence and Drug Survival of Biologics in Treatment-Naïve and Treatment-experienced Adult Patients with Rheumatoid Arthritis.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Etanercept; Humans; Methotrexate; Rituximab | 2023 |
Real-world Comparative Effectiveness of Methotrexate-based Combinations for Rheumatoid Arthritis: A Retrospective Cohort Study.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2023 |
Risks of malignant lymphoma in rheumatoid arthritis patients receiving methotrexate-alone and in combination therapy compared with the general population: A study based on a Japanese medical claims database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; East Asian People; Humans; Lymphoma; Methotrexate; Neoplasms; Retrospective Studies; Treatment Outcome | 2023 |
Diffuse skin findings secondary to lymph node tularemia in a patient with chronic rheumatoid arthritis on methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Lymph Nodes; Methotrexate; Patients; Tularemia | 2023 |
Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Humans; Leflunomide; Methotrexate; Renal Insufficiency; Urea; Uric Acid | 2023 |
Therapeutic Effect of Colony Stimulating Factor 1 Receptor Kinase Inhibitor, JTE-952, on Methotrexate-Refractory Pathology in a Rat Model of Rheumatoid Arthritis.
Topics: Animals; Antineoplastic Agents; Arthritis, Rheumatoid; Macrophage Colony-Stimulating Factor; Methotrexate; Quality of Life; Rats; Receptor Protein-Tyrosine Kinases | 2023 |
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Denmark; Humans; Methotrexate; Norway; Rituximab; Sweden; Tumor Necrosis Factor Inhibitors | 2023 |
Childhood-onset rheumatoid arthritis at a tertiary hospital in Senegal, West Africa.
Topics: Adolescent; Adult; Africa, Western; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Cohort Studies; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Prednisone; Rheumatoid Factor; Senegal; Tertiary Care Centers | 2023 |
Unveiling difficult-to-treat rheumatoid arthritis: long-term impact of biologic or targeted synthetic DMARDs from the KOBIO registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Registries | 2023 |
Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Pyrroles; Treatment Outcome | 2023 |
Assessment of liver fibrosis in patients with rheumatoid arthritis treated with methotrexate: Utility of fibroscan and biochemical markers in routine clinical practice.
Topics: Arthritis, Rheumatoid; Biomarkers; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Methotrexate | 2023 |
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Inflammation; Matrix Metalloproteinases; Methotrexate; Mice; Osteogenesis; Silver | 2023 |
Are all JAK inhibitors for the treatment of rheumatoid arthritis equivalent? An adjusted indirect comparison of the efficacy of tofacitinib, baricitinib, upadacitinib, and filgotinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; C-Reactive Protein; Humans; Janus Kinase Inhibitors; Methotrexate | 2023 |
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Crocus; Drug Therapy, Combination; Methotrexate; Rats; RNA, Messenger | 2023 |
Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Prognosis; Remission Induction; Severity of Illness Index; Treatment Outcome | 2023 |
A new pharmacokinetic model of urinary methotrexate to assess adherence in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Multivariate Analysis; Treatment Outcome | 2023 |
Glucocorticoid trajectories over 2 years in patients with rheumatoid arthritis in a real-life setting.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate | 2023 |
[Pharmacological profiles and clinical efficacy of ozoralizumab (Nanozora
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Infliximab; Japan; Methotrexate; Mice; Receptors, Tumor Necrosis Factor; Syringes; Treatment Outcome; Tumor Necrosis Factor-alpha | 2023 |
MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
Topics: Adalimumab; Arthritis, Psoriatic; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate; Spondylitis, Ankylosing; Venous Thromboembolism | 2023 |
Successful Treatment of a Patient with Drug-Refractory Rheumatoid Arthritis-Associated Interstitial Lung Disease with Upadacitinib: A Case Report.
Topics: Aged; Arthritis, Rheumatoid; Dyspnea; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Prednisolone; Tacrolimus | 2023 |
Combination therapy of methotrexate and iguratimod for female patients with moderate to severe active rheumatoid arthritis and its impact on ovarian function.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Treatment Outcome | 2023 |
Bibliometric analysis of trends in research of Tripterygium wilfordii Hook F for treating rheumatoid arthritis.
Topics: Academies and Institutes; Arthritis, Rheumatoid; Bibliometrics; Humans; Methotrexate; Tripterygium | 2023 |
Investigation of the predictors of the response to Iguratimod therapy: A
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Sulfonamides | 2020 |
Clinical and therapeutic management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: RADAR study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Registries; Retrospective Studies; Treatment Outcome | 2019 |
Efficacy and safety of Ramucirumab and methotrexate co-therapy in rheumatoid arthritis experimental model: Involvement of angiogenic and immunomodulatory signaling.
Topics: Animals; Ankle Joint; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Foot; Gene Expression; Immunomodulation; Interleukin-17; Male; Methotrexate; Neovascularization, Physiologic; Ramucirumab; Rats; STAT3 Transcription Factor; Treatment Outcome; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2019 |
The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Female; Humans; Male; Methotrexate; Middle Aged; T-Lymphocyte Subsets | 2019 |
Development of an algorithm to detect methotrexate wrong frequency error using computerized health care data.
Topics: Administration, Oral; Algorithms; Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; California; Clinical Coding; Delivery of Health Care, Integrated; Drug Administration Schedule; Drug Overdose; Electronic Health Records; Female; Humans; Incidence; International Classification of Diseases; Leucovorin; Male; Medication Errors; Methotrexate; Middle Aged; Product Surveillance, Postmarketing | 2019 |
Deletion at 2q14.3 is associated with worse response to TNF-α blockers in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Genotype; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Polymorphism, Single Nucleotide; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Could a methotrexate blood assay improve adherence?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2019 |
Effectiveness of subcutaneously administered methotrexate in patients with rheumatoid arthritis.
Topics: Administration, Cutaneous; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Overweight; Product Surveillance, Postmarketing; Treatment Outcome | 2019 |
Methotrexate therapy is not associated with increased liver stiffness and significant liver fibrosis in rheumatoid arthritis patients: A cross-sectional controlled study with real-time two-dimensional shear wave elastography.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Elasticity Imaging Techniques; Female; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged | 2019 |
Comparative Persistence of Methotrexate and Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Retrospective Studies; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2020 |
[Methotrexate-associated lymphoproliferative disorders: clinical aspects].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Incidence; Lymphoproliferative Disorders; Methotrexate; Prognosis | 2019 |
The relation between upper extremity joint involvement and grip force in early rheumatoid arthritis: a retrospective study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Hand Strength; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Retrospective Studies; Sweden; Synovitis; Wrist Joint | 2019 |
Clinico-genetic model to predict methotrexate intolerance in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Body Mass Index; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Models, Genetic; Nausea; Polymorphism, Single Nucleotide; Prospective Studies; Vomiting | 2020 |
Simultaneous Development of Progressive Multifocal Leukoencephalopathy and Cryptococcal Meningitis during Methotrexate and Infliximab Treatment.
Topics: Aged; Antifungal Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppression Therapy; Infliximab; JC Virus; Leukoencephalopathy, Progressive Multifocal; Meningitis, Cryptococcal; Methotrexate; Treatment Outcome | 2019 |
Assessment of cognitive function in female rheumatoid arthritis patients: associations with cerebrovascular pathology, depression and anxiety.
Topics: Aged; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Biological Products; Carotid Intima-Media Thickness; Case-Control Studies; Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Depression; Female; Humans; Mental Status and Dementia Tests; Methotrexate; Middle Aged; Middle Cerebral Artery | 2020 |
Suppression of joint destruction with subcutaneous tocilizumab for Japanese patients with rheumatoid arthritis in clinical practice.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Joints; Male; Methotrexate; Middle Aged | 2020 |
[Rheumatoid arthritis in elderly people].
Topics: Age of Onset; Aged; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Inflammation; Male; Methotrexate | 2019 |
Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; DNA Methylation; Female; Humans; Linear Models; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2020 |
Association of
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2020 |
Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis.
Topics: Aged; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Tomography, X-Ray Computed; Treatment Outcome | 2020 |
Paradoxical Löfgren's syndrome in a patient treated with rituximab: interferon is not the key.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Prednisone; Retreatment; Risk Assessment; Rituximab; Sarcoidosis; Treatment Failure | 2020 |
Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study.
Topics: Abatacept; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Biological Products; British Columbia; Chloroquine; Cohort Studies; Cyclophosphamide; Cyclosporine; Deprescriptions; Female; Glucocorticoids; Gold Compounds; Humans; Hydroxychloroquine; Interleukin 1 Receptor Antagonist Protein; Leflunomide; Logistic Models; Maternal Age; Methotrexate; Mycophenolic Acid; Odds Ratio; Preconception Care; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Rheumatology; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors | 2020 |
The slippery road of adherence in chronically ill individuals.
Topics: Arthritis, Rheumatoid; Chronic Disease; Cohort Studies; Humans; Methotrexate | 2020 |
Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Evaluation, Preclinical; Drug Monitoring; Humans; K562 Cells; Metabolomics; Methotrexate | 2020 |
Primary Intraocular Methotrexate-related Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis Undergoing Long-term Methotrexate Therapy.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Tumor; Female; Humans; Intraocular Lymphoma; Leukocyte Count; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Proteins; Visual Acuity | 2021 |
Quality of life and clinical outcomes in Polish patients with high activity rheumatoid arthritis treated with leflunomide (Arava®) in Therapeutic Program: A retrospective analysis of data from the PLUS study.
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Poland; Quality of Life; Retrospective Studies; Treatment Outcome | 2019 |
Cost-Effectiveness of Sarilumab Added to Methotrexate in the Treatment of Adult Patients with Moderately to Severely Active Rheumatoid Arthritis Who Have Inadequate Response or Intolerance to Tumor Necrosis Factor Inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Trees; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Models, Economic; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Young Adult | 2019 |
Nuclear Factor kappa B (NF-κB) Targeted Self-Assembled Nanoparticles Loaded with Methotrexate for Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Male; Methotrexate; Mice; Nanoparticles; NF-kappa B; Particle Size; RAW 264.7 Cells | 2019 |
The effect of methotrexate on tumour necrosis factor concentrations in etanercept-treated rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
[High Expression of Multidrug Resistance Gene-1 Can Aggravate Resistance to Methotrexate in Rheumatoid Arthritis Patients].
Topics: Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Drug Resistance; Fibroblasts; Humans; Methotrexate; Synovial Membrane | 2019 |
The impact of different criteria sets on early remission and identifying its predictors in rheumatoid arthritis: results from an observational cohort (2009-2018).
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; China; Cohort Studies; Female; Glucocorticoids; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Reported Outcome Measures; Remission Induction; Retrospective Studies; Sex Factors; Sulfasalazine | 2020 |
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patients: pooled analyses from several databases.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Risk Factors; Sensitivity and Specificity | 2020 |
Cardiovascular disease in the QUEST-RA study, 10 years later.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Comorbidity; Humans; Methotrexate; Outcome Assessment, Health Care; Prevalence; Risk Assessment; Risk Factors; Surveys and Questionnaires; Tumor Necrosis Factor-alpha | 2019 |
Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Gene Rearrangement; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Methotrexate; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion | 2019 |
Nivolumab for Methotrexate-associated Classic Hodgkin's Lymphoma in a Rheumatoid Arthritis Patient.
Topics: Aged; Antineoplastic Agents, Immunological; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hodgkin Disease; Humans; Methotrexate; Nivolumab | 2020 |
A novel etanercept biosimilar Anbainuo plus methotrexate exhibits increased cost-effectiveness compared to conventional disease-modifying anti-rheumatic drugs in treating rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fc Fragments; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Severity of Illness Index; Treatment Outcome | 2019 |
Risk stratification and clinical course of hepatitis B virus reactivation in rheumatoid arthritis patients with resolved infection: final report of a multicenter prospective observational study at Japanese Red Cross Hospital.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B virus; Hospitals; Humans; Incidence; Japan; Male; Methotrexate; Middle Aged; Prospective Studies; Red Cross; Risk Factors; Virus Activation | 2019 |
Contraceptive Use in Women of Childbearing Ability With Rheumatoid Arthritis.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Contraception; Contraceptive Agents; Female; Humans; Methotrexate; Pregnancy; Young Adult | 2021 |
Cultural Adaptation and Validation of the Methotrexate Intolerance Severity Score in Brazilian Portuguese for Adults With Rheumatoid Arthritis.
Topics: Adult; Arthritis, Rheumatoid; Brazil; Humans; Language; Methotrexate; Reproducibility of Results; Surveys and Questionnaires | 2021 |
Genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a multicenter cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Forecasting; Humans; Male; Methotrexate; Middle Aged; Models, Genetic; Treatment Outcome | 2020 |
Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Inflammation; Locomotion; Male; Methotrexate; Mice; Pain; Skin Temperature | 2019 |
Levels of CXCL13 and sICAM-1 correlate with disease activity score in patients with rheumatoid arthritis treated with tocilizumab.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Chemokine CXCL13; Clinical Trials as Topic; Humans; Intercellular Adhesion Molecule-1; Methotrexate; Treatment Outcome | 2019 |
Parallel comparison of fibroblast-like synoviocytes from the surgically removed hyperplastic synovial tissues of rheumatoid arthritis and osteoarthritis patients.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Cells, Cultured; Flow Cytometry; Humans; Hyperplasia; Methotrexate; Osteoarthritis; Primary Cell Culture; Synovial Membrane; Synoviocytes; Tumor Necrosis Factor-alpha | 2019 |
Effectiveness of methotrexate in combination therapy in a rat collagen-induced arthritis model.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Combined Modality Therapy; Drug Therapy, Combination; Glucocorticoids; Male; Methotrexate; Prednisone; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Th17 Cells | 2019 |
Successful cessation of tumor necrosis factor inhibitor treatment in rheumatoid arthritis patients and potential predictors for early flare: An observational study in routine clinical care.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor Inhibitors | 2020 |
5-year remission rate after the discontinuation of adalimumab in patients with rheumatoid arthritis: Long-term follow-up results of the HONOR study.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction | 2020 |
Proteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Female; Germany; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Proteomics; Treatment Outcome; United Kingdom | 2020 |
Disease activity measures at baseline predict structural damage progression: data from the randomized, controlled AMPLE and AVERT trials.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Severity of Illness Index; Treatment Outcome | 2020 |
Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate; Pharmacogenetics; Precision Medicine | 2020 |
Association between malignancy and methotrexate and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasms; Treatment Outcome | 2020 |
Development of Methotrexate and Minocycline Loaded Nanoparticles for the Effective Treatment of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Minocycline; Nanoparticles | 2019 |
Role of Interleukin 6 Inhibitors in the Management of Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Quality of Life; Treatment Outcome | 2021 |
Acute Effects of Glucocorticoid Treatment, TNFα or IL-6R Blockade on Bone Turnover Markers and Wnt Inhibitors in Early Rheumatoid Arthritis: A Pilot Study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Remodeling; Collagen Type I; Glucocorticoids; Humans; Methotrexate; Pilot Projects; Receptors, Interleukin-6; Retrospective Studies; Tumor Necrosis Factor-alpha | 2020 |
Tuberculous arthritis in a patient with rheumatoid arthritis treated with methotrexate alone.
Topics: Aged, 80 and over; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Tuberculosis, Osteoarticular | 2020 |
Early non-response to certolizumab pegol in rheumatoid arthritis predicts failure to achieve low disease activity at 1 year: data from a prospective observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Certolizumab Pegol; Drug Therapy, Combination; Female; France; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Failure | 2020 |
[Neurological symptoms in a patient on anti-TNF therapy, methotrexate and prednisolone for rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Opportunistic Infections; Prednisolone; Toxoplasmosis, Cerebral; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
Immunohistochemical Assessment of the Diagnostic Utility of PD-L1 (Clone SP142) for Methotrexate-Associated Lymphoproliferative Disorders With an Emphasis of Neoplastic PD-L1 (Clone SP142)-Positive Classic Hodgkin Lymphoma Type.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; B7-H1 Antigen; Female; Hodgkin Disease; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged | 2020 |
Multiple Skin Ulcers in a Rheumatoid Arthritis Patient: Answer.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Methotrexate; Middle Aged; Skin Ulcer | 2020 |
Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosenescence; Male; Medication Adherence; Methotrexate; Registries; Treatment Outcome; Tumor Necrosis Factor Inhibitors; United Kingdom | 2020 |
Cost-effectiveness analysis of etanercept plus methotrexate vs triple therapy in treating Chinese rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; China; Cost-Benefit Analysis; Drug Therapy, Combination; Etanercept; Female; Health Expenditures; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Remission Induction; Severity of Illness Index | 2020 |
Thrombotic microangiopathy and liver toxicity due to a combination therapy of leflunomide and methotrexate: a case report.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Leflunomide; Methotrexate; Middle Aged; Thrombotic Microangiopathies | 2020 |
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genotype; Humans; Liver; Liver Function Tests; Liver-Specific Organic Anion Transporter 1; Logistic Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Thymidylate Synthase | 2020 |
Effect on efficacy and safety trial outcomes of also enrolling patients on ongoing glucocorticoid therapy in rheumatoid arthritis clinical trials of tocilizumab or adalimumab or methotrexate monotherapy.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Infections; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2020 |
[Cytopenia secondary to low-dose methotrexate].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2020 |
Association of a Type 2-Polarized T Cell Phenotype With Methotrexate Nonresponse in Patients With Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; CTLA-4 Antigen; Female; Flow Cytometry; Hepatitis A Virus Cellular Receptor 2; Humans; Immunologic Memory; Immunophenotyping; Inducible T-Cell Co-Stimulator Protein; Interferon-gamma; Interleukin-13; Interleukin-17; Male; Methotrexate; Middle Aged; Programmed Cell Death 1 Receptor; T-Lymphocyte Subsets; T-Lymphocytes; T-Lymphocytes, Regulatory; Treatment Failure; Treatment Outcome | 2020 |
A highlight on CD4
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Disease Progression; Fatty Acids, Omega-3; Fluorescent Antibody Technique; Freund's Adjuvant; Humans; Male; Methotrexate; Rats; Rats, Inbred Strains; Spleen | 2020 |
Methotrexate-Induced Pneumonitis in Rheumatoid Arthritis: Long-term Treatment With Tofacitinib Therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pneumonia; Pyrimidines; Pyrroles; Treatment Outcome | 2021 |
Relative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in comparison to adalimumab in patients with active rheumatoid arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Bayes Theorem; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome; Triazoles | 2020 |
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.
Topics: Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Catalase; Disease Models, Animal; Diterpenes; Edema; Freund's Adjuvant; Glutathione; Inflammation; Interleukin-1beta; Interleukin-6; Joints; Male; Methotrexate; Neutrophils; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Synovial Membrane; Tumor Necrosis Factor-alpha | 2020 |
A Call to Systematically Monitor for Adverse Events in Users of Low-Dose Methotrexate Therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2020 |
Distinct decrease in peripheral lymphocytes in EBER-positive cases of MTX-LPD.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Japan; Lymphocyte Count; Lymphocytes; Lymphoproliferative Disorders; Male; Methotrexate; Outcome Assessment, Health Care; Recurrence; Withholding Treatment | 2021 |
Predictors of presenteeism, absenteeism and job loss in patients commencing methotrexate or biologic therapy for rheumatoid arthritis.
Topics: Absenteeism; Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Fatigue; Female; Humans; Male; Methotrexate; Middle Aged; Presenteeism; Psychological Distress; Sex Factors; Sick Leave; Time Factors; Unemployment; Young Adult | 2020 |
Treatment Patterns and Costs in Biologic DMARD-Naive Patients with Rheumatoid Arthritis Initiating Etanercept or Adalimumab with or Without Methotrexate.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Costs; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2020 |
Rheumatoid artrhitis treatment in Brazil: data from a large real-life multicenter study.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Chi-Square Distribution; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Statistics, Nonparametric; Sulfasalazine | 2020 |
A case of esophageal cancer complicated with methotrexate-related lymphoproliferative disorder.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Esophageal Neoplasms; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Tomography, X-Ray Computed | 2020 |
Candida bloodstream infection in patients with systemic autoimmune diseases.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Candida; Candidemia; Comorbidity; Cross Infection; Female; France; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Opportunistic Infections; Retrospective Studies; Spain; Survival Rate | 2020 |
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4
Topics: Adult; Aged; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; CpG Islands; DNA Methylation; Female; Gene Ontology; Humans; Immunologic Memory; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2020 |
Important determinants of the patient choice between TNF- vs. non-TNF Biologic disease-modifying anti-rheumatic drugs (DMARDs) for active rheumatoid arthritis (RA).
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Etanercept; Female; Humans; Methotrexate; Patient Preference | 2020 |
Clinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Incidence; Japan; Lymphocyte Count; Lymphocytes; Lymphoproliferative Disorders; Male; Methotrexate; Recurrence; Risk Assessment; Withholding Treatment | 2021 |
Usefulness of daily folic acid supplementation during methotrexate treatment of Japanese patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Dose-Response Relationship, Drug; Drug Monitoring; Female; Folic Acid; Hematinics; Humans; Japan; Male; Methotrexate; Treatment Outcome | 2021 |
Liver Fibrosis in Rheumatoid Arthritis Patients Treated with Methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2020 |
Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis.
Topics: Adalimumab; Adolescent; Adult; Aged; Alzheimer Disease; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Case-Control Studies; Colitis, Ulcerative; Etanercept; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk; Tumor Necrosis Factor Inhibitors; Young Adult | 2020 |
Methotrexate-associated Lymphoproliferative Disorder of the Small Intestine.
Topics: Arthritis, Rheumatoid; Humans; Intestine, Small; Lymphoproliferative Disorders; Methotrexate | 2021 |
Surfactant-Free, Self-Assembled Nanomicelles-Based Transdermal Hydrogel for Safe and Targeted Delivery of Methotrexate against Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Drug Carriers; Hydrogels; Methotrexate; Mice; Surface-Active Agents | 2020 |
Does methotrexate improve TNF inhibitor drug survival in elderly patients with RA?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Rheumatology | 2020 |
ASSOCIATIONS BETWEEN EFFICACY OF THE THERAPY AND CIRCADIAN FLUCTUATIONS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH TOLL-LIKE RECEPTORS 2 EXPRESSION, AND NOS3 POLYMORPHISM IN FEMALES WITH RHEUMATOID ARTHRITIS.
Topics: Adult; Arthritis, Rheumatoid; Circadian Rhythm; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Nitric Oxide Synthase Type III; Prednisone; Toll-Like Receptor 2; Treatment Outcome; Ukraine | 2020 |
A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Cytokines; Drug Delivery Systems; Drug Therapy, Combination; Gene Silencing; Hydrogels; Indomethacin; Injections, Intra-Articular; Matrix Metalloproteinase 9; Methotrexate; Mice; Nanoparticles; RAW 264.7 Cells; RNA, Small Interfering | 2020 |
Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Dementia; Female; Humans; Male; Methotrexate; Middle Aged; Netherlands; Retrospective Studies; Risk Factors | 2020 |
Targeted hexagonal Pd nanosheet combination therapy for rheumatoid arthritis via the photothermal controlled release of MTX.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Female; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Methotrexate; Mice; Mice, Inbred DBA; Nanostructures; Palladium; Photochemotherapy; RAW 264.7 Cells | 2019 |
Regulatory T cells in patients with early untreated rheumatoid arthritis: Phenotypic changes in the course of methotrexate treatment.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Female; Forkhead Transcription Factors; Humans; Male; Methotrexate; Middle Aged; T-Lymphocytes, Regulatory | 2020 |
Methotrexate-associated lymphoproliferative disorders in the central nervous system and stomach: A case report.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Arthritis, Rheumatoid; Central Nervous System Neoplasms; Diagnosis, Differential; Endoscopy, Digestive System; Female; Gait Ataxia; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Rituximab; Stomach Neoplasms; Treatment Outcome | 2020 |
Association between red cell distribution width and response to methotrexate in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Erythrocyte Indices; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; ROC Curve; Time Factors; Treatment Outcome | 2020 |
Cost-effectiveness analysis of treatment sequences containing tofacitinib for the treatment of rheumatoid arthritis in Spain.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Spain; Treatment Outcome | 2020 |
Economic Evaluation of Sequences of Biological Treatments for Patients With Moderate-to-Severe Rheumatoid Arthritis and Inadequate Response or Intolerance to Methotrexate in France.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; France; Humans; Methotrexate; Models, Economic; Quality-Adjusted Life Years; Severity of Illness Index | 2020 |
DAS28-ESR and DAS28-CRP - are they Interchangeable in Measuring the Activity of Rheumatoid Arthritis in Response to Treatment with Biological Agents?
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; C-Reactive Protein; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Retrospective Studies; Rituximab; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
Association of High Serum Interleukin-6 Levels With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab From Adalimumab or Methotrexate in a Post Hoc Analysis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Disease Progression; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Pain Measurement; Patient Reported Outcome Measures; Prognosis; Randomized Controlled Trials as Topic | 2020 |
Tapering of biological antirheumatic drugs in rheumatoid arthritis patients is achievable and cost-effective in daily clinical practice: data from the Brussels UCLouvain RA Cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
A case of bilateral methotrexate-associated diffuse large B-cell lymphomas of the breasts with unique clinical presentation and outcome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Breast; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Fatal Outcome; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Mammography; Methotrexate; Middle Aged; Prednisone; Rituximab; Ultrasonography, Mammary; Vincristine | 2020 |
Role of folate-conjugated glycol-chitosan nanoparticles in modulating the activated macrophages to ameliorate inflammatory arthritis: in vitro and in vivo activities.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Survival; Chitosan; Drug Liberation; Female; Folic Acid; HEK293 Cells; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Mice; Nanoparticles; Rats, Wistar; RAW 264.7 Cells | 2020 |
[A survey on therapy strategies for rheumatoid arthritis in Chinese rheumatologists].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; China; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Rheumatologists; Surveys and Questionnaires | 2020 |
Real-World Outcomes Associated With Methotrexate, Sulfasalazine, and Hydroxychloroquine Triple Therapy Versus Tumor Necrosis Factor Inhibitor/Methotrexate Combination Therapy in Patients With Rheumatoid Arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Registries; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors; United States | 2021 |
Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing | 2020 |
Heart Failure Risk Associated With Rheumatoid Arthritis-Related Chronic Inflammation.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Electronic Health Records; Female; Heart Failure; Humans; Incidence; Inflammation Mediators; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Nerve Tissue Proteins; Prognosis; Prospective Studies; Proteomics; Retrospective Studies; Risk Assessment; Risk Factors; Tennessee; Time Factors | 2020 |
Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Humans; Methotrexate; Mice; Synovial Fluid; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor Ligand Superfamily Member 15; Tumor Necrosis Factor-alpha | 2020 |
Does concomitant methotrexate confer clinical benefits in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Health Status; Humans; Male; Methotrexate; Pain; Retrospective Studies; Severity of Illness Index | 2020 |
Prognosis of pneumonia in patients with rheumatoid arthritis: the role of medication and disease activity prior to admission a population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Case-Control Studies; Cohort Studies; Denmark; Female; Glucocorticoids; Hospitalization; Humans; Male; Methotrexate; Middle Aged; Mortality; Platelet Count; Pneumonia; Predictive Value of Tests; Prednisolone; Prognosis | 2020 |
Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis.
Topics: Adult; Age of Onset; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Female; Humans; Injections, Subcutaneous; Interleukin-6; Male; Methotrexate; Middle Aged; Prednisolone; Self Administration; Treatment Outcome | 2020 |
The clinical impact of absolute lymphocyte count in peripheral blood among patients with methotrexate - associated lymphoproliferative disorders.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphocyte Count; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies | 2020 |
Circulating CD19+CD24hiCD38hi regulatory B cells as biomarkers of response to methotrexate in early rheumatoid arthritis.
Topics: ADP-ribosyl Cyclase 1; Adult; Anti-Citrullinated Protein Antibodies; Antigens, CD19; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes, Regulatory; Biomarkers; Case-Control Studies; CD24 Antigen; Coculture Techniques; Down-Regulation; Female; Humans; Interferon-gamma; Interleukins; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; T-Lymphocytes; Treatment Outcome | 2020 |
[Probable rheumatoid meningitis complicated by cryptococcal meningitis: A case report].
Topics: Antibodies; Arthritis, Rheumatoid; Biomarkers; Brain; Female; Humans; Magnetic Resonance Imaging; Meningitis; Meningitis, Cryptococcal; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisolone; Treatment Outcome | 2020 |
One-third of patients are low-adherent to methotrexate for rheumatoid arthritis at the initiation of a first biologic. A cross-sectional study investigating adherence rate and factors.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cross-Sectional Studies; Drug Therapy, Combination; Humans; Medication Adherence; Methotrexate; Treatment Outcome | 2020 |
Evaluation of Encapsulated Eugenol by Chitosan Nanoparticles on the aggressive model of rheumatoid arthritis.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; Chemokine CCL2; Chitosan; Drug Carriers; Eugenol; Malondialdehyde; Methotrexate; Nanoparticles; Rats, Wistar; Transforming Growth Factor beta | 2020 |
Progressive Multifocal Leukoencephalopathy during Tocilizumab Treatment for Rheumatoid Arthritis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Receptors, Interleukin-6 | 2020 |
Analysis of association of ADORA
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Association Studies; Genotype; Haplotypes; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Adenosine A2A; Receptor, Adenosine A3; Treatment Outcome | 2020 |
Methotrexate-associated Hodgkin Lymphoma in a Patient with Rheumatoid Arthritis Successfully Treated with Brentuximab Vedotin in Combination with Doxorubicin, Vinblastine, and Dacarbazine (BV+AVD).
Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Brentuximab Vedotin; Dacarbazine; Doxorubicin; Female; Hodgkin Disease; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Treatment Outcome; Vinblastine | 2020 |
Methotrexate reduces withdrawal rates of TNF inhibitors due to ineffectiveness in rheumatoid arthritis but only in patients who are seropositive.
Topics: Adalimumab; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Etanercept; Humans; Immunosuppressive Agents; Methotrexate; Retrospective Studies; Rheumatoid Factor; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
Autoantibodies against a novel citrullinated fibrinogen peptide related to smoking status, disease activity and therapeutic response to methotrexate in cuban patients with early rheumatoid arthritis.
Topics: Adult; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Cuba; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Smoking; Treatment Outcome | 2020 |
Safety and Tolerability of Subcutaneous Methotrexate in Routine Clinical Practice.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Patient Safety; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2021 |
Clinical features and outcomes of COVID-19 in patients with rheumatic diseases treated with biological and synthetic targeted therapies.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Glucocorticoids; Hospitalization; Humans; Hydroxychloroquine; Intensive Care Units; Interleukin 1 Receptor Antagonist Protein; Janus Kinase Inhibitors; Male; Methotrexate; Middle Aged; Pandemics; Pneumonia, Viral; Rheumatic Diseases; Rituximab; SARS-CoV-2; Spain; Spondylarthropathies; Tumor Necrosis Factor Inhibitors | 2020 |
Clinical effectiveness of iguratimod based on real-world data of patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Retrospective Studies; Sulfonamides; Treatment Outcome | 2021 |
Tocilizumab Increases Body Weight and Serum Adipokine Levels in Patients with Rheumatoid Arthritis Independently of Their Treatment Response: a Retrospective Cohort Study.
Topics: Adiponectin; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Body Weight; Drug Therapy, Combination; Female; Heart Disease Risk Factors; Humans; Leptin; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Resistin; Retrospective Studies; Tumor Necrosis Factor-alpha | 2020 |
Characteristics of Chikungunya virus infection in patients with established rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chikungunya Fever; Colombia; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
[Biological therapy after COVID-19 infection : No reactivation of a COVID-19 infection with positive SARS-CoV-2 antibody status under biological therapy].
Topics: Antibodies, Viral; Arthritis, Rheumatoid; Betacoronavirus; Biological Therapy; Coronavirus Infections; COVID-19; Humans; Leflunomide; Methotrexate; Pandemics; Pneumonia, Viral; SARS-CoV-2; Tumor Necrosis Factor Inhibitors; Virus Activation | 2020 |
Predicting the treatment response of certolizumab for individual adult patients with rheumatoid arthritis: protocol for an individual participant data meta-analysis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Methotrexate; Treatment Outcome | 2020 |
Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Japan; Male; Methotrexate; Prospective Studies; Symptom Flare Up; Treatment Outcome | 2020 |
Selection and perception of methotrexate treatment information in people with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Hospital Information Systems; Humans; Male; Methotrexate; Middle Aged; Perception; Retrospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2020 |
Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing; Young Adult | 2020 |
Circulating Small Noncoding RNA Biomarkers of Response to Triple Disease-modifying Antirheumatic Drug Therapy in White Women With Early Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Methotrexate; RNA, Small Untranslated; Sulfasalazine; Treatment Outcome | 2020 |
Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Humans; Methotrexate; Mice; Multifunctional Nanoparticles; Nanoparticles | 2020 |
Translating research into clinical practice: quality improvement to halve non-adherence to methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Consultants; Cost Savings; Humans; Medication Adherence; Methotrexate; Motivational Interviewing; Patient Education as Topic; Quality Improvement; Remission Induction; Self Report; Surveys and Questionnaires; Time Factors | 2021 |
A need for consensus guideline update: recommend explicit restriction of methotrexate in end-stage renal patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Consensus; Humans; Kidney Failure, Chronic; Male; Methotrexate; Practice Guidelines as Topic | 2020 |
Potential of Sonophoresis as a Skin Penetration Technique in the Treatment of Rheumatoid Arthritis with Transdermal Patch.
Topics: Administration, Cutaneous; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Male; Methotrexate; Rats; Rats, Wistar; Skin; Skin Absorption; Transdermal Patch; Ultrasonic Therapy | 2020 |
Methotrexate: what are the true risks of treatment?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2020 |
A rare case of allergic contact dermatitis caused by 3-O-ethyl-L-ascorbic acid in skin-whitening cosmetics identified under immunosuppressive therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Ascorbic Acid; Dermatitis, Allergic Contact; Erythema; Etanercept; Facial Dermatoses; Female; Humans; Immunosuppressive Agents; Methotrexate; Patch Tests; Skin Cream | 2020 |
Is methotrexate contra-indicated in lung involvement of rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications, Drug; Humans; Lung; Methotrexate | 2020 |
Autoimmune Conditions: Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Quality of Life; Severity of Illness Index | 2020 |
Contributing factors of clinical outcomes at 1 year post-diagnosis in early rheumatoid arthritis patients with tightly controlled disease activity in clinical practice: a retrospective study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Synovitis | 2021 |
Efficacy and safety of dual filtration plasmapheresis combined with biological agents in active refractory rheumatod arthritis: A retrospective cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Combined Modality Therapy; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Plasmapheresis; Retrospective Studies; Treatment Outcome | 2020 |
Does autoimmune thyroid disease affect rheumatoid arthritis disease activity or response to methotrexate?
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Public Health Surveillance; Registries; Severity of Illness Index; Sweden; Thyroid Diseases; Treatment Outcome | 2020 |
Pop a pill or give myself a shot? Patient perspectives of disease-modifying anti-rheumatic drug choice for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged | 2021 |
Rapidly progressive glomerulonephritis after introduction of certolizumab pegol: a case report.
Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Certolizumab Pegol; Female; Glomerulonephritis; Humans; Kidney; Methotrexate; Peroxidase; Rituximab; Tumor Necrosis Factor Inhibitors | 2021 |
Adverse Effects of Low-Dose Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2020 |
Adverse Effects of Low-Dose Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2020 |
Upadacitinib in MTX-naive RA.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Patients; Safety | 2020 |
Patient-ready syringes containing 25 mg/mL methotrexate can be kept at temperature ranging from 4 °C to 37 °C for up to 12 weeks for use in psoriatic and rheumatologic conditions.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Syringes; Temperature | 2022 |
Risk factors associated with initiation of a biologic disease modifying anti-rheumatic drug in patients with rheumatoid arthritis: A nested case-control study on 34,925 patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Methotrexate; Republic of Korea; Risk Factors | 2021 |
Predictors of long-term clinical remission in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Glucocorticoids; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Methotrexate; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Remission Induction; Retrospective Studies | 2021 |
Low-Dose Methotrexate Causing Fatal Pancytopenia in a Patient With Severe Malnutrition.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Malnutrition; Methotrexate; Pancytopenia | 2021 |
Effect on Costs and Quality-adjusted Life-years of Treat-to-target Treatment Strategies Initiating Methotrexate, or Tocilizumab, or Their Combination in Early Rheumatoid Arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate; Quality-Adjusted Life Years; Treatment Outcome | 2021 |
Dextran sulfate-modified pH-sensitive layered double hydroxide nanocomposites for treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Dextran Sulfate; Hydrogen-Ion Concentration; Hydroxides; Methotrexate; Nanocomposites; Nanoparticles; Rats | 2021 |
Methotrexate and risk of interstitial lung disease and respiratory failure in rheumatoid arthritis: a nationwide population-based study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Denmark; Female; Humans; Incidence; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Registries; Respiratory Insufficiency; Risk; Young Adult | 2021 |
The Risk of Cardiovascular Events Associated With Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2021 |
Two-year Outcomes of Infliximab Discontinuation in Patients with Rheumatoid Arthritis: A Retrospective Analysis from a Single Center.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; Deprescriptions; Female; Glucocorticoids; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prednisolone; Recurrence; Remission Induction; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
Assessment of the association of baseline anti-CarbV and anti-MCV antibodies with response to treatment and radiographic progression in an RA population treated with either methotrexate or baricitinib: post-hoc analyses from RA-BEGIN.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Disease Progression; Humans; Methotrexate; Purines; Pyrazoles; Sulfonamides; Vimentin | 2020 |
Response to: 'Tapering antirheumatic drugs in a resource-poor setting: real-world evidence' by Haroon
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate | 2022 |
Dose tapering of biologic agents in patients with rheumatoid arthritis-results from a cohort study in Germany.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Biological Products; Cohort Studies; Drug Tapering; Germany; Humans; Methotrexate | 2021 |
High frequency of methotrexate intolerance in longstanding rheumatoid arthritis: using the methotrexate intolerance severity score (MISS).
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Odds Ratio; Risk Factors; Vomiting | 2020 |
Effect of disease duration and other characteristics on efficacy outcomes in clinical trials of tocilizumab for rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index; Treatment Outcome | 2021 |
A methotrexate-associated lymphoproliferative disorder expressing CD10 and BCL6 with the IGH/CCND1 translocation.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 14; Cyclophosphamide; Doxorubicin; Female; Humans; Immunosuppressive Agents; Lymph Nodes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Proteins; Neprilysin; Oncogene Proteins, Fusion; Prednisolone; Proto-Oncogene Proteins c-bcl-6; Remission Induction; Rituximab; Translocation, Genetic; Vincristine | 2020 |
Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error.
Topics: Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Medication Errors; Methotrexate; Middle Aged; Mucositis; Pancytopenia | 2020 |
Persistence on biologic DMARD monotherapy after achieving rheumatoid arthritis disease control on combination therapy: retrospective analysis of corrona registry data.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Registries; Remission Induction; Retrospective Studies; Tumor Necrosis Factor Inhibitors | 2021 |
[Low-dose methotrexate].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate | 2020 |
Distinct features between HLA-DR+ and HLA-DR- PD-1hi CXCR5- T peripheral helper cells in seropositive rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; T-Lymphocytes, Helper-Inducer | 2021 |
Predictive ability, validity, and responsiveness of the multi-biomarker disease activity score in patients with rheumatoid arthritis initiating methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Humans; Methotrexate; Severity of Illness Index; Treatment Outcome | 2020 |
Rituximab for rheumatoid arthritis-associated large granular lymphocytic leukemia, a retrospective case series.
Topics: Arthritis, Rheumatoid; Female; Humans; Leukemia, Large Granular Lymphocytic; Methotrexate; Middle Aged; Retrospective Studies; Rituximab | 2020 |
Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes.
Topics: Animals; Arthritis, Rheumatoid; Cell Line; Endothelial Cells; Fluorescent Dyes; Human Umbilical Vein Endothelial Cells; Humans; Indocyanine Green; Integrin alphaVbeta3; Liposomes; Male; Methotrexate; Mice; Oligopeptides; Optical Imaging; RAW 264.7 Cells; Spectroscopy, Near-Infrared; Swine; Ultrasonic Therapy; Ultrasonic Waves | 2020 |
The long-term observation of patients with rheumatoid arthritis who achieved a biological disease-modifying antirheumatic drug-free condition with adalimumab.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2021 |
Post-marketing surveillance of high-dose methotrexate (>8 mg/week) in Japanese patients with rheumatoid arthritis: A post hoc sub-analysis of patients according to duration of prior methotrexate use.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Treatment Outcome | 2021 |
Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis.
Topics: Alternative Splicing; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Introns; Male; Methotrexate; Middle Aged; Peptide Synthases; Real-Time Polymerase Chain Reaction; Treatment Failure | 2021 |
Enhanced treatment strategies and distinct disease outcomes among autoantibody-positive and -negative rheumatoid arthritis patients over 25 years: A longitudinal cohort study in the Netherlands.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers, Pharmacological; Cohort Studies; Disease Progression; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Netherlands; Severity of Illness Index | 2020 |
Methrotexate Treatment Inmunomodulates Abnormal Cytokine Expression by T CD4 Lymphocytes Present in DMARD-Naïve Rheumatoid Arthritis Patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Female; Flow Cytometry; Humans; Interferon-gamma; Interleukin-17; Interleukin-4; Male; Methotrexate; Middle Aged; Phosphorylation; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT6 Transcription Factor | 2020 |
Can the adherence to quality of care indicators for early rheumatoid arthritis in clinical practice reduce risk of hospitalisation? Retrospective cohort study based on the Record Linkage of Rheumatic Disease study of the Italian Society for Rheumatology.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Hospitalization; Humans; Italy; Male; Methotrexate; Middle Aged; Quality Indicators, Health Care; Retrospective Studies; Rheumatology | 2020 |
The Effect of Dose Escalation on the Cost-Effectiveness of Etanercept and Adalimumab with Methotrexate Among Patients with Moderate to Severe Rheumatoid Arthritis.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Models, Theoretical; Quality-Adjusted Life Years; Severity of Illness Index; United States | 2020 |
Use of healthcare resources in a cohort of rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs or tofacitinib.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Quality of Life; Retrospective Studies | 2021 |
Six-month flare risk after discontinuing long-term methotrexate treatment in patients having rheumatoid arthritis with low disease activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Forecasting; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Retrospective Studies; Treatment Outcome; Withholding Treatment | 2020 |
Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interdisciplinary Communication; Liver Diseases; Male; Methotrexate; Middle Aged; Patient Care Team; Retrospective Studies | 2020 |
Cost-effectiveness analysis of tofacitinib compared with adalimumab and etanercept in the treatment of severe active rheumatoid arthritis; Iranian experience.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Etanercept; Female; Humans; Iran; Male; Markov Chains; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Quality-Adjusted Life Years; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2021 |
Adenosine Deaminase Gene Polymorphism and Baseline Serum Level of Adenosine Deaminase as a Biomarker of Response to Methotrexate in Rheumatoid Arthritis.
Topics: Adenosine Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Humans; Methotrexate; Polymorphism, Single Nucleotide; Treatment Outcome | 2021 |
Benefits of Methotrexate Use on Cardiovascular Disease Risk Among Rheumatoid Arthritis Patients Initiating Biologic Disease-modifying Antirheumatic Drugs.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Female; Humans; Medicare; Methotrexate; Middle Aged; Retrospective Studies; United States | 2021 |
Methotrexate use does not increase the prevalence of hepatic steatosis: a real-world retrospective nested case-control study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Humans; Methotrexate; Prevalence; Retrospective Studies | 2021 |
Tuberculosis osteomyelitis in an old fused hip; activated by prednisolone, salazosulfapyridine, and low-dose methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Male; Methotrexate; Osteomyelitis; Prednisolone; Sulfasalazine; Treatment Outcome; Tuberculosis, Osteoarticular | 2020 |
A case of acute diffuse large B cell lymphoma in an anti-human T-cell leukaemia virus type 1-positive rheumatoid arthritis patient treated with methotrexate, who died.
Topics: Aged; Arthritis, Rheumatoid; Autopsy; Biomarkers; Disease Susceptibility; Fatal Outcome; Female; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Methotrexate | 2020 |
Risk of higher dose methotrexate for renal impairment in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Japan; Kidney; Kidney Diseases; Male; Methotrexate; Middle Aged; Regression Analysis; Retrospective Studies; Surveys and Questionnaires | 2020 |
Assessment of liver fibrosis markers in people with rheumatoid arthritis on methotrexate.
Topics: Arthritis, Rheumatoid; Aspartate Aminotransferases; Biomarkers; Elasticity Imaging Techniques; Humans; Liver; Liver Cirrhosis; Methotrexate | 2022 |
Impact of disease activity and treatments on ovarian reserve in patients with rheumatoid arthritis in the ESPOIR cohort.
Topics: Adolescent; Adult; Age Factors; Anti-Mullerian Hormone; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Ovarian Reserve; Young Adult | 2021 |
Methotrexate-Associated Lymphoproliferative Disorders Mimicking Granulomatosis With Polyangiitis: A Radiological Diagnostic Challenge.
Topics: Arthritis, Rheumatoid; Female; Granulomatosis with Polyangiitis; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2022 |
Response to: 'Correspondence on 'Tapering towards DMARD-free remission in rheumatoid arthritis' by Garcia
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2023 |
Treatment of rheumatoid arthritis after regression of lymphoproliferative disorders in patients treated with methotrexate: a retrospective, multi-center descriptive study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies | 2022 |
Oral ulcers with amyloidosis secondary to rheumatoid arthritis.
Topics: Aged; Amyloidosis; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Oral Ulcer; Prednisolone | 2021 |
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquine.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Middle Aged; Sulfasalazine; Survival Rate; Treatment Outcome | 2021 |
Risk of haematological events and preventive effect of folic acid in methotrexate users with chronic kidney disease and rheumatoid arthritis: Analysis of the Japanese Adverse Drug Event Report database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Japan; Methotrexate; Renal Insufficiency, Chronic | 2021 |
Changes in the illness perceptions of patients with rheumatoid arthritis over the first year of methotrexate therapy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Perception; Quality of Life; Treatment Outcome | 2021 |
Relationship Between Depression and Disease Activity in United States Veterans With Early Rheumatoid Arthritis Receiving Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Depression; Drug Therapy, Combination; Humans; Male; Methotrexate; Severity of Illness Index; Treatment Outcome; United States; Veterans | 2021 |
Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats.
Topics: Anemia; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Freund's Adjuvant; Ginsenosides; Male; Methotrexate; Rats; Rats, Sprague-Dawley | 2020 |
Update on the diagnosis and management of early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Quality of Life | 2020 |
[Risk factors for disseminated herpes zoster].
Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; Arthritis, Rheumatoid; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Methotrexate; Risk Factors | 2020 |
Adverse Events Profile of Low-dose Methotrexate in Nepalese Patients with Rheumatoid Arthritis: an Observational Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Nepal; Prospective Studies; Treatment Outcome | 2020 |
COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
Topics: Adalimumab; Adult; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Azathioprine; Betacoronavirus; Biological Therapy; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Testing; Drug Combinations; Drug Therapy, Combination; Humans; Lopinavir; Male; Methotrexate; Oseltamivir; Pandemics; Pneumonia, Viral; Prednisolone; Ritonavir; SARS-CoV-2 | 2020 |
Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Probability; Remission Induction; Treatment Outcome | 2020 |
A Study of the Efficacy and Safety of Subcutaneous Injections of Tocilizumab in Adults with Rheumatoid Arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures | 2020 |
Rapid Onset of Efficacy of Baricitinib in Chinese Patients with Moderate to Severe Rheumatoid Arthritis: Results from Study RA-BALANCE.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; China; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate; Purines; Pyrazoles; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2021 |
[Mechanism of
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Male; Methotrexate; Mice; Mice, Inbred DBA; Th17 Cells | 2020 |
Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Methotrexate; Nuclear Medicine; Radiopharmaceuticals | 2021 |
Efficacy of Tocilizumab Monotherapy Versus Tocilizumab and Methotrexate Combination Therapy in the Prevention of Radiographic Progression in Rheumatoid Arthritis: An Analysis Using Individual Patient Data From Multiple Clinical Trials.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2022 |
Refinement and validation of infrared thermal imaging (IRT): a non-invasive technique to measure disease activity in a mouse model of rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Methotrexate; Mice; Reproducibility of Results | 2020 |
Remission of gastrointestinal follicular lymphoma after abatacept treatment against rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoma, Follicular; Methotrexate; Remission Induction; Treatment Outcome | 2022 |
Perturbation of the human gastrointestinal tract microbial ecosystem by oral drugs to treat chronic disease results in a spectrum of individual specific patterns of extinction and persistence of dominant microbial strains.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Ecosystem; Female; Gastrointestinal Microbiome; Gastrointestinal Tract; Glycosides; Humans; Male; Methotrexate; Tripterygium | 2020 |
Methotrexate-associated lymphoproliferative disorder with histopathological features of histiocytic necrotizing lymphadenitis.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Biopsy; Female; Herpesvirus 4, Human; Histiocytic Necrotizing Lymphadenitis; Humans; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate | 2021 |
The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bacteroidetes; Clostridiales; Cohort Studies; Escherichia; Euryarchaeota; Female; Firmicutes; Gastrointestinal Microbiome; Humans; Machine Learning; Male; Metabolomics; Metagenomics; Methotrexate; Middle Aged; Prognosis; RNA, Ribosomal, 16S; Shigella; Treatment Outcome | 2021 |
Comparison of therapeutic efficacy and mechanism of paclitaxel alone or in combination with methotrexate in a collagen-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Methotrexate; Paclitaxel; Rats; Synovial Membrane | 2022 |
Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Withholding Treatment | 2021 |
Successful treatment with photodynamic therapy in a patient with nasal mucocutaneous leishmaniasis undergoing treatment with TNFα inhibitor.
Topics: Adalimumab; Aminolevulinic Acid; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunocompromised Host; Leishmaniasis, Mucocutaneous; Methotrexate; Middle Aged; Photochemotherapy; Photosensitizing Agents; Skin Cream; Treatment Outcome; Tumor Necrosis Factor-alpha | 2020 |
Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Drug Liberation; Humans; Hyaluronic Acid; Metal-Organic Frameworks; Methotrexate | 2021 |
Overall survival and post-spontaneous regression relapse-free survival of patients with lymphoproliferative disorders associated with rheumatoid arthritis: a multi-center retrospective cohort study.
Topics: Aged; Arthritis, Rheumatoid; Hodgkin Disease; Humans; Longitudinal Studies; Lymphoproliferative Disorders; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies | 2022 |
Cricoarytenoid arthritis in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arytenoid Cartilage; Cricoid Cartilage; Female; Glucocorticoids; Hoarseness; Humans; Laryngeal Edema; Laryngoscopy; Methotrexate; Positron Emission Tomography Computed Tomography; Prednisolone; Pyriform Sinus | 2021 |
Effectiveness of initial methotrexate-based treatment approaches in early rheumatoid arthritis: an elicitation of rheumatologists' beliefs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Methotrexate; Practice Patterns, Physicians'; Rheumatologists | 2021 |
[Clinical characteristics of elderly and younger onset rheumatoid arthritis].
Topics: Age of Onset; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged | 2020 |
Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Chemokines; Cytokines; Diabetes Mellitus; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Registries; Risk Factors; Severity of Illness Index; Sex Factors | 2021 |
Disease-modifying antirheumatic drugs and organising pneumonia.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cryptogenic Organizing Pneumonia; Female; Humans; Leflunomide; Lung; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2021 |
New insights into the treatment of CTD-ILD.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Connective Tissue Diseases; Disease Progression; Humans; Indoles; Interleukin-6; Lung Diseases, Interstitial; Methotrexate; Prevalence; Protein Kinase Inhibitors; Pulmonary Fibrosis; Randomized Controlled Trials as Topic; Scleroderma, Systemic; Vital Capacity | 2021 |
Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Prospective Studies; Remission Induction; Treatment Outcome | 2021 |
Hyaluronate-functionalized hydroxyapatite nanoparticles laden with methotrexate and teriflunomide for the treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Crotonates; Cytokines; Drug Carriers; Drug Evaluation, Preclinical; Drug Liberation; Durapatite; Hyaluronic Acid; Hydroxybutyrates; Liver; Methotrexate; Mice; Nanoparticles; Nitriles; Rats; Rats, Wistar; RAW 264.7 Cells; Spectroscopy, Fourier Transform Infrared; Tissue Distribution; Toluidines | 2021 |
Association of methotrexate use and lymphoproliferative disorder in patients with rheumatoid arthritis: Results from a Japanese multi-institutional retrospective study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Japan; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Retrospective Studies | 2022 |
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteria; Female; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Metabolomics; Methotrexate; Mice; Mice, Inbred C57BL; Phylogeny; Purines; Pyrimidines; RNA, Ribosomal, 16S; Tetrahydrofolate Dehydrogenase; Transcriptome | 2021 |
Methotrexate prolongs TNF inhibitor survival, but only in autoantibody-positive rheumatoid arthritis: a validation study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Humans; Methotrexate; Rheumatoid Factor; Tumor Necrosis Factor Inhibitors | 2023 |
Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity.
Topics: Abatacept; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Female; Humans; Interferon-alpha; Interleukin-10; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phosphorylation; Severity of Illness Index; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor | 2021 |
THE EFFECT OF ATORVASTATINUM IN THE TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Humans; Leptin; Methotrexate; Tumor Necrosis Factor-alpha | 2020 |
SPECT imaging and highly efficient therapy of rheumatoid arthritis based on hyperbranched semiconducting polymer nanoparticles.
Topics: Animals; Arthritis, Rheumatoid; Methotrexate; Mice; Nanoparticles; Polymers; Tomography, Emission-Computed, Single-Photon | 2021 |
Patients and clinicians define symptom levels and meaningful change for PROMIS pain interference and fatigue in RA using bookmarking.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatigue; Female; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Reported Outcome Measures; Severity of Illness Index; Symptom Assessment; Treatment Outcome | 2021 |
Concomitant Large Loculated Pleural and Pericardial Effusions in a Patient with Rheumatoid Arthritis on Methotrexate.
Topics: Arthritis, Rheumatoid; Diagnostic Imaging; Humans; Male; Methotrexate; Middle Aged; Pericardial Effusion; Splenomegaly | 2020 |
Factors predicting addition of disease-modifying antirheumatic drugs after initial methotrexate monotherapy in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2021 |
Rheumatoid arthritis relapse in patients with other iatrogenic immunodeficiency-associated lymphoproliferative disorders and its treatment.
Topics: Arthritis, Rheumatoid; Humans; Iatrogenic Disease; Lymphoproliferative Disorders; Methotrexate; Recurrence; Retrospective Studies | 2021 |
Good response to methotrexate is associated with a decrease in the gene expression of ABCG2, a drug transporter, in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Therapy, Combination; Gene Expression; Humans; Methotrexate; Neoplasm Proteins; Prospective Studies; Treatment Outcome | 2021 |
Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Japan; Male; Methotrexate; Middle Aged; Propensity Score; Registries; Retrospective Studies; Treatment Outcome; Withholding Treatment | 2021 |
Characteristics of rheumatoid arthritis with immunodeficiency-associated lymphoproliferative disorders to regress spontaneously by the withdrawal of methotrexate and their clinical course: A retrospective, multicenter, case-control study.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Retrospective Studies | 2022 |
Network theoretic analysis of JAK/STAT pathway and extrapolation to drugs and viruses including COVID-19.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Azetidines; Gene Regulatory Networks; Humans; Janus Kinases; Methotrexate; Models, Statistical; Piperidines; Prednisolone; Purines; Pyrazoles; Pyrimidines; Rituximab; Signal Transduction; STAT Transcription Factors; Sulfonamides; Virus Diseases | 2021 |
Drug retention of sarilumab, baricitinib, and tofacitinib in patients with rheumatoid arthritis: the ANSWER cohort study.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Cohort Studies; Female; Humans; Methotrexate; Middle Aged; Pharmaceutical Preparations; Piperidines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Retrospective Studies; Sulfonamides; Treatment Outcome | 2021 |
Consideration of differences in drug usage between young-onset and elderly-onset rheumatoid arthritis with target of low disease activity.
Topics: Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Factor | 2021 |
Delayed diagnosis of rheumatoid arthritis in an elderly patient presenting with weakness and desolation.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Delayed Diagnosis; Depression; Diagnosis, Differential; Diagnostic Imaging; Glucocorticoids; Humans; Male; Methotrexate; Muscle Weakness | 2021 |
Interpretation of network meta-analyses of the efficacy of rheumatoid arthritis drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Janus Kinases; Methotrexate; Network Meta-Analysis | 2021 |
Long-term methotrexate use in rheumatoid arthritis patients: real-world data from the MARTE study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Injections, Intramuscular; Injections, Subcutaneous; Italy; Male; Methotrexate; Postmenopause; Sex Factors; Smokers; Socioeconomic Factors; Time Factors | 2021 |
Gut microbiome could predict drug response in RA.
Topics: Arthritis, Rheumatoid; Gastrointestinal Microbiome; Humans; Methotrexate; Pharmaceutical Preparations | 2021 |
Stratification of methotrexate-induced oral ulcers in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Oral Ulcer; Treatment Outcome | 2021 |
Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Female; Formates; Humans; Leucovorin; Metabolic Networks and Pathways; Methotrexate; Mice, Inbred C57BL; Mitochondria; Vitamin B Complex | 2021 |
Disappearance of bilateral adrenal tumours: immunodeficiency-associated lymphoproliferative disorder in a patient with rheumatoid arthritis.
Topics: Adrenal Gland Neoplasms; Aged; Arthritis, Rheumatoid; Deprescriptions; Drug Therapy, Combination; Female; Humans; Iatrogenic Disease; Immunosuppressive Agents; Infliximab; Lymphoma; Lymphoproliferative Disorders; Methotrexate; Neoplasm Regression, Spontaneous; Tumor Necrosis Factor Inhibitors | 2021 |
[EBV-positive MTX-associated lymphoproliferative disorder and Ig M myeloma in rheumatoid arthritis].
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate; Paraproteinemias | 2021 |
Do people with rheumatoid arthritis maintain their physical activity level at treatment onset over the first year of methotrexate therapy?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Exercise; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Prospective Studies | 2021 |
Systemic EBV-Positive Methotrexate-Related Lymphoproliferative Disorder Associated With Skin Lesion Resembling EBV-Positive Mucocutaneous Ulcer: A Report of Two Cases.
Topics: Aged; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Eruptions; Epstein-Barr Virus Infections; Female; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate; Skin Ulcer | 2021 |
Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: A population-based study.
Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Denmark; Female; Follow-Up Studies; Humans; Incidence; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis; Risk Assessment; Risk Factors; Severity of Illness Index | 2021 |
Methotrexate does not increase the risk of liver fibrosis in patients with rheumatoid arthritis: assessment by ultrasound elastography (ARFI-MetRA study).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Elasticity Imaging Techniques; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Ultrasonography | 2021 |
The addition of iguratimod can reduce methotrexate dose in rheumatoid arthritis with clinical remission.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Humans; Methotrexate; Remission Induction; Sulfonamides; Treatment Outcome | 2022 |
Sustained Remission in Patients With Rheumatoid Arthritis Receiving Triple Therapy Compared to Biologic Therapy: A Swedish Nationwide Register Study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chloroquine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Odds Ratio; Registries; Sulfasalazine; Sweden; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2021 |
Prevalence of liver fibrosis by Fibroscan in patients on long-term methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Child, Preschool; Cross-Sectional Studies; Elasticity Imaging Techniques; Female; Humans; Liver; Liver Cirrhosis; Methotrexate; Middle Aged; Prevalence | 2021 |
Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; CpG Islands; DNA Methylation; Epigenome; Female; Genome-Wide Association Study; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prospective Studies | 2021 |
Clinicopathological characteristics of lymphoproliferative disorders in 232 patients with rheumatoid arthritis in Japan: A retrospective, multicenter, descriptive study.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Japan; Lymphadenopathy; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Retrospective Studies; Ulcer | 2022 |
[Patient safety in the treatment of rheumatic diseases : Laboratory monitoring in methotrexate treatment].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Laboratories; Methotrexate; Patient Safety; Retrospective Studies; Rheumatic Diseases | 2021 |
Methotrexate and Cardiovascular Disease in Patients With Rheumatoid Arthritis: Insights and Novel Speculations.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate | 2021 |
Effects of rhizome of Atractylodes koreana (Nakai) Kitam on intestinal flora and metabolites in rats with rheumatoid arthritis.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Atractylodes; Cytokines; DNA; Down-Regulation; Gastrointestinal Microbiome; Gene Expression Regulation; Inflammation; Intestines; Male; Methotrexate; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome; RNA, Ribosomal, 16S; Synovial Membrane | 2021 |
Serum miRNA Signature in Rheumatoid Arthritis and "At-Risk Individuals".
Topics: Adult; Aged; Aged, 80 and over; Arthralgia; Arthritis, Rheumatoid; Biomarkers; Circulating MicroRNA; Computational Biology; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; ROC Curve | 2021 |
Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients Receiving Combination Therapy: Comment on the Article by Curtis et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Methotrexate | 2021 |
High prevalence of methotrexate use in patients with Epstein-Barr virus-positive mucocutaneous ulcer may cause confounding bias.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Oral Ulcer; Prevalence; Receptors, Interleukin-2 | 2021 |
Methotrexate-associated lymphoproliferative disorder with an osteolytic vertebral lesion in an elderly patient with rheumatoid arthritis: A case report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Thoracic Vertebrae | 2021 |
Methotrexate-associated lymphoproliferative disorder of the thoracic spine in a patient with rheumatoid arthritis receiving methotrexate: a case report.
Topics: Arthritis, Rheumatoid; Female; Humans; Lumbar Vertebrae; Lymphoma; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2021 |
MTX optimization or adding bDMARD equally improve disease activity in rheumatoid arthritis: results from the prospective study STRATEGE.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 2021 |
Current Treatment Strategies in Rheumatoid Arthritis After Methotrexate Are Not Enough to Maintain Sustained Remission: There Is No Holy Grail!
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2021 |
Abatacept in monotherapy vs combined in interstitial lung disease of rheumatoid arthritis-multicentre study of 263 Caucasian patients.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Retrospective Studies | 2021 |
Polymorphism of genes involved in methotrexate pathway: Predictors of response to methotrexate therapy in Indian rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Genotype; Humans; Hydroxymethyl and Formyl Transferases; Immunosuppressive Agents; India; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide; Pyrophosphatases | 2021 |
Acute hepatitis E in an immunocompromised patient with seropositive rheumatoid arthritis on rituximab and long-term methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hepatitis E; Humans; Immunocompromised Host; Methotrexate; Middle Aged; Rituximab | 2021 |
Effectiveness and tolerability of oral vs subcutaneous methotrexate in patients with rheumatoid arthritis.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Humans; Injections, Subcutaneous; Methotrexate; Retrospective Studies | 2021 |
Assessing the risk of rapid radiographic progression in Hungarian rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Disease Progression; Drug Therapy, Combination; Humans; Hungary; Male; Methotrexate; Retrospective Studies; Treatment Outcome | 2021 |
[Early onset of methotrexate-associated lymphoproliferative disorder mimicking Hodgkin's lymphoma].
Topics: Arthritis, Rheumatoid; Female; Hodgkin Disease; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2022 |
Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Longitudinal Studies; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2021 |
Five-year treat-to-target outcomes after methotrexate induction therapy with or without other csDMARDs and temporary glucocorticoids for rheumatoid arthritis in the CareRA trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; C-Reactive Protein; Drug Therapy, Combination; Glucocorticoids; Humans; Induction Chemotherapy; Methotrexate; Treatment Outcome | 2021 |
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Bleomycin; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; Follow-Up Studies; Humans; Janus Kinases; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prednisone; Progression-Free Survival; Proportional Hazards Models; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha; Vinblastine; Vincristine | 2021 |
Tofacitinib in the Treatment of Moderate-to-Severe Rheumatoid Arthritis in China: A Cost-Effectiveness Analysis Based on a Mapping Algorithm Derived from a Chinese Population.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; China; Cost-Benefit Analysis; Humans; Methotrexate; Piperidines; Pyrimidines; Quality-Adjusted Life Years | 2021 |
Immune Reconstitution Inflammatory Syndrome-like Condition Associated with Pneumocystis jirovecii Pneumonia During Folinic Acid Treatment in a Rheumatoid Arthritis Patient.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Immune Reconstitution Inflammatory Syndrome; Leucovorin; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis | 2021 |
Patients' perspectives of rheumatoid arthritis treatment: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Humans; Japan; Methotrexate; Middle Aged; Practice Guidelines as Topic; Rheumatology; Surveys and Questionnaires | 2022 |
Patients With Rheumatoid Arthritis With an Inadequate Response to Disease-Modifying Antirheumatic Drugs at a Higher Risk of Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Incidence; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Taiwan | 2021 |
A dose-dependent beneficial effect of methotrexate on the risk of interstitial lung disease in rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged | 2021 |
Assessment of patients affected by rheumatoid arthritis eligible for biotechnological agents and evaluation of their healthcare resource utilization and related costs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Delivery of Health Care; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2021 |
Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Drug Liberation; Hydrogels; Methotrexate; Polyelectrolytes; Rats | 2021 |
MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients.
Topics: Antigens, CD19; Arthritis, Rheumatoid; B-Lymphocytes; Biomarkers; Computational Biology; Disease Management; Disease Susceptibility; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Humans; Immunosuppressive Agents; Methotrexate; MicroRNAs; RNA Interference | 2021 |
Current smoking predicts inadequate response to methotrexate monotherapy in rheumatoid arthritis patients naïve to DMARDs: Results from a retrospective cohort study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Smoking; Treatment Failure | 2021 |
Methotrexate reduces circulating Th17 cells and impairs plasmablast and memory B cell expansions following pneumococcal conjugate immunization in RA patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Case-Control Studies; Female; Humans; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Vaccination | 2021 |
Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Delayed Diagnosis; Female; Humans; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Respiratory Tract Infections; Spain | 2021 |
Bioflavonoid Robinin from
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Astragalus Plant; Drug Synergism; Drug Therapy, Combination; Flavonoids; Flowers; Freund's Adjuvant; Humans; Lipids; Male; Methotrexate; Plant Leaves; Rats | 2021 |
The association between increased body mass index and response to conventional synthetic disease-modifying anti-rheumatic drug treatment in rheumatoid arthritis: results from the METEOR database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Databases as Topic; Female; Humans; Linear Models; Logistic Models; Male; Methotrexate; Middle Aged; Obesity; Patient Acuity; Treatment Outcome | 2022 |
Risk of liver fibrosis induced by methotrexate and other rheumatoid arthritis medications according to the Fibrosis-4 Index.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Treatment Outcome | 2022 |
The synergistic efficacy of hydroxychloroquine with methotrexate is accompanied by increased erythrocyte mean corpuscular volume.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Synergism; Drug Therapy, Combination; Erythrocyte Indices; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies | 2022 |
Tofacitinib versus tocilizumab in the treatment of biological-naïve or previous biological-failure patients with methotrexate-refractory active rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Piperidines; Pyrimidines | 2021 |
Elderly patients with comorbidities in the definition of difficult-to-treat rheumatoid arthritis.
Topics: Abatacept; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Comorbidity; Drug Resistance; Female; Fractures, Bone; Glucocorticoids; Humans; Hypertension; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Myocardial Ischemia; Prednisolone; Renal Insufficiency, Chronic; Severity of Illness Index; Stroke; Tumor Necrosis Factor Inhibitors | 2021 |
Autopsy of a case of rheumatoid arthritis with severe bicytopoenia due to gelatinous transformation of the bone marrow.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autopsy; Bone Marrow; Fatal Outcome; Female; Hematologic Diseases; Humans; Methotrexate; Severity of Illness Index | 2021 |
Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis.
Topics: Adult; Arthritis, Rheumatoid; Chemokines; Cluster Analysis; Cytokines; Humans; Inflammation; Lymphocytes; Methotrexate; Middle Aged; Spondylarthritis | 2021 |
Investigating changes in disease activity as a mediator of cardiovascular risk reduction with methotrexate use in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Coronary Artery Disease; Female; Heart Disease Risk Factors; Heart Failure; Hospitalization; Humans; Incidence; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Stroke | 2021 |
Therapeutic education improves rheumatoid arthritis patients' knowledge about methotrexate: a single center retrospective study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Methotrexate; Middle Aged; Patient Education as Topic; Retrospective Studies; Surveys and Questionnaires | 2021 |
Extensive soft tissue xanthomatosis masquerading as tophaceous gout in a normolipidemic man.
Topics: Aged; Arthralgia; Arthritis; Arthritis, Rheumatoid; Cholesterol; Diagnosis, Differential; Finger Joint; Gout; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Microscopy, Polarization; Radiography; Synovial Fluid; Treatment Outcome; Xanthomatosis | 2021 |
Initial methotrexate dosage is not associated with an increased risk of liver toxicity in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Retrospective Studies | 2021 |
Severe lupus induced by the tumor necrosis factor-alpha inhibitor Anbainuo: a case report.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin Fc Fragments; Lupus Erythematosus, Systemic; Methotrexate; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha | 2021 |
Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Malaysia; Male; Methotrexate; Middle Aged; Osteoarthritis; Periodontitis; Serogroup | 2021 |
Successful BNT162b2 booster vaccinations in a patient with rheumatoid arthritis and initially negative antibody response.
Topics: Antibodies, Neutralizing; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Heterocyclic Compounds, 3-Ring; Humans; Immunization, Secondary; Immunocompromised Host; Immunogenicity, Vaccine; Male; Methotrexate; Middle Aged; Polycythemia Vera; SARS-CoV-2; Vasculitis, Leukocytoclastic, Cutaneous | 2021 |
Methotrexate and glucocorticoids, but not anticytokine therapy, impair the immunogenicity of a single dose of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic inflammatory arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Female; Glucocorticoids; Humans; Immunogenicity, Vaccine; Male; Methotrexate; Middle Aged; SARS-CoV-2 | 2021 |
Early prediction of clinical response to anti-TNF treatment using multi-omics and machine learning in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Leukocytes, Mononuclear; Machine Learning; Methotrexate; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
Development of Intravascular Large B-cell Lymphoma during Methotrexate Treatment for Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2022 |
Correspondence on 'Five-year treat-to-target outcomes after methotrexate induction therapy with or without other csDMARDs and temporary glucocorticoids for rheumatoid arthritis in the CareRA trial'.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Induction Chemotherapy; Methotrexate; Treatment Outcome | 2023 |
Phytochemical and In-Vivo Anti-Arthritic Significance of
Topics: Aloe; Animals; Antioxidants; Antirheumatic Agents; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Freund's Adjuvant; Male; Methotrexate; Oxidative Stress; Phytochemicals; Plant Extracts; Plant Leaves; Rats; Rats, Wistar | 2021 |
The maximum dose and duration in the therapy single use methotrexate to achieve remission by rheumatoid arthritis patients through disease activity score 28 (DAS28).
Topics: Arthritis, Rheumatoid; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2021 |
Patient's experiences of the barriers and facilitators to Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Focus Groups; Humans; Methotrexate; Qualitative Research; Rheumatic Diseases | 2022 |
Small intestinal follicular lymphoma induced by methotrexate: a case report.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Jejunum; Lymphoma, Follicular; Lymphoproliferative Disorders; Methotrexate; Neoplasm Recurrence, Local | 2021 |
[Oral Mucosal Diffuse Large B-cell Lymphoma Caused by Long-term Oral Methotrexate:Report of One Case].
Topics: Arthritis, Rheumatoid; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate | 2021 |
Neutrophil count reduction 1 month after initiating tocilizumab can predict clinical remission within 1 year in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Neutrophils; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2022 |
Effect of abatacept treatment on serum osteoclast-related biomarkers in patients with rheumatoid arthritis (RA): A multicenter RA ultrasound prospective cohort in Japan.
Topics: Abatacept; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Female; Humans; Japan; Male; Methotrexate; Osteoclasts; Prospective Studies; RANK Ligand; Remission Induction; Severity of Illness Index; Tartrate-Resistant Acid Phosphatase | 2021 |
Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results.
Topics: Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Joints; Methotrexate; Quality of Life | 2021 |
AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Female; Genes; Genotyping Techniques; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Aryl Hydrocarbon; Reduced Folate Carrier Protein; Treatment Outcome; Young Adult | 2021 |
Abatacept in rheumatoid arthritis-associated interstitial lung disease: short-term outcomes and predictors of progression.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged | 2021 |
Folate-methotrexate loaded bovine serum albumin nanoparticles preparation: an
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Drug Delivery Systems; Folic Acid; Methotrexate; Nanoparticles; Serum Albumin, Bovine | 2023 |
Smoking and Methotrexate Inefficacy in Rheumatoid Arthritis: What About Underlying Molecular Mechanisms?
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Smoking | 2021 |
Heterogeneity in Patient Characteristics and Differences in Treatment Across 4 Canadian Rheumatoid Arthritis Cohorts.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Ontario | 2022 |
Methotrexate and theaflavin-3, 3'-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS.
Topics: Adult; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Autophagy; Biflavonoids; Catechin; Cells, Cultured; Disease Progression; Drug Synergism; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Male; Methotrexate; Middle Aged; Osteoarthritis; Synovial Fluid; Synoviocytes | 2021 |
Involvement of Epstein-Barr virus in the development and spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate | 2022 |
Sequences of biological treatments for patients with moderate-to-severe rheumatoid arthritis in the era of treat-to-target in China: a cost-effectiveness analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Humans; Methotrexate; Quality-Adjusted Life Years | 2022 |
Methotrexate use and liver outcomes in psoriasis and rheumatoid arthritis patients: A commentary on "Risk of liver disease in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis receiving methotrexate: A population-based study".
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Liver Diseases; Methotrexate; Psoriasis | 2021 |
Response to: "Methotrexate Use and Liver Outcomes in Psoriasis and Rheumatoid Arthritis Patients: A Commentary on 'Risk of liver disease in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis receiving methotrexate: A population-based st
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Liver Diseases; Methotrexate; Psoriasis | 2021 |
Iguratimod triggers the relapse of methotrexate-associated lymphoproliferative disorder.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Female; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate; Recurrence; Sulfonamides | 2021 |
Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; India; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prevalence; Reproducibility of Results; Risk Assessment; Risk Factors; Surveys and Questionnaires | 2021 |
Lipidated Methotrexate Microbubbles: A Promising Rheumatoid Arthritis Theranostic Medicine Manipulated via Ultrasonic Irradiation.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Methotrexate; Microbubbles; Precision Medicine; Rabbits; Ultrasonics | 2021 |
The aggressive clinical courses of Hodgkin lymphoma primarily diagnosed as methotrexate-induced non-specific lymphoproliferative disorder in patients with rheumatoid arthritis.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Arthritis, Rheumatoid; Female; Hodgkin Disease; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prednisolone; Recurrence; Remission Induction | 2017 |
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.
Topics: Aged; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Risk | 2017 |
Therapeutic effect of quercetin in collagen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chemokine CCL2; Collagen; Disease Models, Animal; Inflammation; Interleukin-17; Interleukin-1beta; Joints; Methotrexate; Mice; Mice, Inbred C57BL; Protective Agents; Quercetin; Tumor Necrosis Factor-alpha | 2017 |
Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; India; Male; Methotrexate; Middle Aged; Pharmacogenomic Variants; Thymidylate Synthase; Treatment Outcome | 2017 |
Methotrexate Reduced TNF Bioactivity in Rheumatoid Arthritis Patients Treated with Infliximab.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Assay; Cohort Studies; Female; Humans; Infliximab; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2017 |
Development of Albumin Coupled, Cholesterol Stabilized, Lipid Nanoemulsion of Methotrexate, and TNF-α Inhibitor for Improved In Vivo Efficacy Against Rheumatoid Arthritis.
Topics: Albumins; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Drug Liberation; Emulsions; Etanercept; Female; Lipids; Methotrexate; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2017 |
Three out of four disease-modifying anti-rheumatic drug-naïve rheumatoid arthritis patients meet 28-joint Disease Activity Score remission at 12 months: results from the FIN-ERA cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Drug Therapy, Combination; Female; Finland; Glucocorticoids; Humans; Hydroxychloroquine; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Patient Reported Outcome Measures; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2017 |
Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; Diet; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Inflammation Mediators; Male; Methotrexate; Middle Aged; Pain Measurement; Pain, Intractable; Prospective Studies; Protective Factors; Risk Factors; Time Factors; Treatment Outcome | 2018 |
Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Dextran Sulfate; Drug Carriers; Male; Methotrexate; Mice; Nanoparticles; Optical Imaging; RAW 264.7 Cells; Theranostic Nanomedicine | 2017 |
Clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: Comparison of diffuse large B-cell lymphoma and classical Hodgkin lymphoma types.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Disease Progression; Female; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged | 2017 |
Cytomegalovirus retinitis followed by immune recovery uveitis in an elderly patient with rheumatoid arthritis undergoing administration of methotrexate and tofacitinib combination therapy.
Topics: Aged; Antiviral Agents; Arthritis, Rheumatoid; Cytomegalovirus Retinitis; Ganciclovir; Humans; Immunosuppressive Agents; Intravitreal Injections; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Uveitis | 2017 |
Methotrexate-induced dysautonomia in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Primary Dysautonomias | 2017 |
Association Between Medications and Herpes Zoster in Japanese Patients with Rheumatoid Arthritis: A 5-year Prospective Cohort Study.
Topics: Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Etanercept; Female; Herpes Zoster; Humans; Incidence; Japan; Male; Methotrexate; Middle Aged | 2017 |
Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment.
Topics: Activities of Daily Living; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Multivariate Analysis; Psychiatric Status Rating Scales; Quality of Life; Retrospective Studies; Rheumatoid Factor; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2017 |
[Post-vaccination varicella in a patient receiving methotrexate].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chickenpox; Chickenpox Vaccine; DNA, Viral; Female; Herpesvirus 3, Human; Humans; Methotrexate; Pancytopenia; Vaccination | 2017 |
Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Interleukin-1beta; Liposomes; Methotrexate; Rats; Tumor Necrosis Factor-alpha | 2017 |
Vitamin D and Calcium Are Required during Denosumab Treatment in Osteoporosis with Rheumatoid Arthritis.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium Carbonate; Denosumab; Dietary Supplements; Female; Humans; Methotrexate; Osteoporosis; Prednisolone; Retrospective Studies; Vitamin D | 2017 |
CpG-specific methylation at rheumatoid arthritis diagnosis as a marker of treatment response.
Topics: ADAMTS Proteins; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Butyrophilins; CpG Islands; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Humans; Hydroxychloroquine; Joint Capsule; Methotrexate; Sulfasalazine; T-Lymphocytes | 2017 |
Design characteristics of the Corrona Japan rheumatoid arthritis registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Japan; Methotrexate; Prospective Studies; Registries; Research Design; Tumor Necrosis Factor-alpha | 2018 |
Alternative interpretation of data for recommendations on how to manage rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2017 |
Long-term outcome is better when a methotrexate-based treatment strategy is combined with 10 mg prednisone daily: follow-up after the second Computer-Assisted Management in Early Rheumatoid Arthritis trial.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Therapy, Computer-Assisted; Early Medical Intervention; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisone; Randomized Controlled Trials as Topic; Retrospective Studies; Treatment Outcome | 2017 |
Contribution of subjective Disease Activity Score 28 (DAS28) components to the response to treatment of rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2017 |
Characteristics and risk factors of lymphoproliferative disorders among patients with rheumatoid arthritis concurrently treated with methotrexate: a nested case-control study of the IORRA cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Regression, Spontaneous; Risk Factors | 2017 |
Tofacitinib attenuates arthritis manifestations and reduces the pathogenic CD4 T cells in adjuvant arthritis rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Protein; CD4-Positive T-Lymphocytes; Foot; Foot Joints; Forelimb; Hindlimb; Interferon-gamma; Interleukin-1beta; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spleen | 2017 |
Effects of iguratimod on the levels of circulating regulators of bone remodeling and bone remodeling markers in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Bone Remodeling; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfonamides | 2017 |
Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate.
Topics: Aloe; Annexin A5; Anthraquinones; Apoptosis; Arthritis, Rheumatoid; Cell Cycle; Cell Line; Cell Proliferation; Humans; Lymphocytes; Methotrexate; Synovial Membrane; Synoviocytes | 2017 |
HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.
Topics: Arthritis, Rheumatoid; Genome-Wide Association Study; HLA-A Antigens; Humans; Lung Diseases, Interstitial; Methotrexate; Pneumonia; United Kingdom | 2017 |
Response to: '
Topics: Arthritis, Rheumatoid; Genome-Wide Association Study; HLA-A Antigens; Humans; Lung Diseases, Interstitial; Methotrexate; Pneumonia; United Kingdom | 2017 |
Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Pilot Projects; Ribonucleosides; Treatment Outcome | 2017 |
Regulatory B cells in rheumatoid arthritis: Alterations in patients receiving anti-TNF therapy.
Topics: Adalimumab; Adolescent; Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes, Regulatory; Drug Therapy, Combination; Etanercept; Female; Humans; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Cost-utility analysis of certolizumab pegol in combination with methotrexate in patients with moderate-to-severe active rheumatoid arthritis in Greece.
Topics: Adalimumab; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost Savings; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Etanercept; Greece; Health Services Research; Humans; Markov Chains; Methotrexate; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Remission Induction; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Resistance; Electron Transport Chain Complex Proteins; Female; Gene Expression Profiling; Humans; Male; Methotrexate; Middle Aged; Transcriptome | 2017 |
Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Cost-Benefit Analysis; Drug Therapy, Combination; Etanercept; Female; Humans; Life Tables; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years | 2017 |
Daily oral administration of low-dose methotrexate has greater antirheumatic effects in collagen-induced arthritis rats.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Disease Progression; Drug Administration Schedule; Female; Methotrexate; Rats; Rats, Inbred Lew | 2017 |
Factorial Analysis of Hepatitis B Virus Reactivation-Induced Hepatitis B Using JADER.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Cyclophosphamide; Databases, Factual; Doxorubicin; Factor Analysis, Statistical; Female; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Japan; Male; Methotrexate; Middle Aged; Prednisolone; Recurrence; Rituximab; Vincristine; Young Adult | 2017 |
In-vivo monitoring of anti-folate therapy in arthritic rats using [
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Fluorine Radioisotopes; Folic Acid; Male; Methotrexate; Polyethylene Glycols; Positron-Emission Tomography; Rats; Rats, Wistar | 2017 |
Rheumatoid arthritis-related interstitial lung disease (RA-ILD): methotrexate and the severity of lung disease are associated to prognosis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index; Tomography, X-Ray Computed; Treatment Outcome | 2017 |
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.
Topics: Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2018 |
Response to: Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis by Kremer and Weinblatt.
Topics: Alcohol Drinking; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Diseases; Humans; Methotrexate | 2018 |
Optimization of biological therapy in rheumatoid arthritis patients: outcomes from the CREATE registry after 2 years of follow-up.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Follow-Up Studies; Health Care Costs; Humans; Male; Methotrexate; Middle Aged; Registries; Remission Induction; Treatment Outcome | 2017 |
Performances of Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than the gold standard Disease Assessment Score (DAS-28-CRP) to assess rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Female; Health Status; Humans; Inflammation Mediators; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Remission Induction; Reproducibility of Results; Severity of Illness Index; Time Factors; Treatment Outcome | 2018 |
[Over-expression of mdr1/P-gp is associated with methotrexate resistance in patients with rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Female; Humans; Male; Methotrexate; Middle Aged; RNA, Messenger | 2017 |
Methotrexate-induced Hypersensitivity Pneumonitis appearing after 30 years of use: a case report.
Topics: Administration, Oral; Aged; Alveolitis, Extrinsic Allergic; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Lung; Methotrexate; Prednisone; Radiography; Tomography, X-Ray Computed | 2017 |
Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis.
Topics: Adalimumab; Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Female; Genetic Engineering; Genetic Therapy; Humans; Male; Methotrexate; Mice; Mice, SCID; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Cost-effectiveness of Biological Disease-modifying Antirheumatic Drugs for the Treatment of Rheumatoid Arthritis: Implications for Clinical Practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Humans; Methotrexate | 2017 |
Clinical characteristics of methotrexate-associated lymphoproliferative disorders: relationship between absolute lymphocyte count recovery and spontaneous regression.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Lymphocyte Count; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Remission Induction; Remission, Spontaneous; Retrospective Studies; Symptom Assessment | 2017 |
Rheumatoid arthritis: JAK-ing up inadequate RA therapy.
Topics: Adalimumab; Arthritis, Rheumatoid; Double-Blind Method; Humans; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2017 |
Breast Cancer in Patients of Rheumatoid Arthritis with Methotrexate Therapy Mimicking Histopathological Changes after Neoadjuvant Chemotherapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Chemotherapy, Adjuvant; Female; Humans; Lymph Nodes; Mastectomy; Methotrexate; Middle Aged; Neoadjuvant Therapy | 2017 |
Real-world clinical experience of biological disease modifying anti-rheumatic drugs in Malaysia rheumatoid arthritis patients.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Hypersensitivity; Infections; Malaysia; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Crescentic glomerular nephritis associated with rheumatoid arthritis: a case report.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Edema; Female; Glomerulonephritis; Humans; Kidney; Methotrexate; Middle Aged; Proteinuria | 2017 |
Do depression and anxiety reduce the likelihood of remission in rheumatoid arthritis and psoriatic arthritis? Data from the prospective multicentre NOR-DMARD study.
Topics: Adult; Aged; Antirheumatic Agents; Anxiety; Arthralgia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Depression; Female; Follow-Up Studies; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Increased baseline RUNX2, caspase 3 and p21 gene expressions in the peripheral blood of disease-modifying anti-rheumatic drug-naïve rheumatoid arthritis patients are associated with improved clinical response to methotrexate therapy.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Autophagy-Related Protein-1 Homolog; Biomarkers; Case-Control Studies; Caspase 3; Core Binding Factor Alpha 1 Subunit; Cyclin-Dependent Kinase Inhibitor p21; Female; Gene Expression Profiling; Humans; Intracellular Signaling Peptides and Proteins; Joints; Male; Matrix Metalloproteinase 9; Methotrexate; Middle Aged; Predictive Value of Tests; ROC Curve; Time Factors; Transcriptome; Treatment Outcome; Up-Regulation; Young Adult | 2017 |
Prevalence of glucose intolerance in rheumatoid arthritis patients at a tertiary care centre in Haryana.
Topics: Adult; Arthritis, Rheumatoid; Body Mass Index; Drug Therapy, Combination; Female; Glucose Intolerance; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prevalence; Sulfasalazine; Tertiary Care Centers | 2017 |
Etanercept is effective as monotherapy or in combination with methotrexate in rheumatoid arthritis: subanalysis of an observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Germany; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome | 2017 |
Delayed anti-TNF therapy increases the risk of total knee replacement in patients with severe rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Tumor Necrosis Factor-alpha | 2017 |
Assessing joint destruction in the knees of patients with rheumatoid arthritis by using a semi-automated software for magnetic resonance imaging: therapeutic effect of methotrexate plus etanercept compared with methotrexate monotherapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Image Enhancement; Knee Joint; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Software | 2018 |
[SUSTAINABILITY OF RITUXIMAB IN CONCOMMITANT TREATMENT WITH METHOTREXATE OR LEFLUNOMIDE IN PATIENTS WITH RHEUMATOID ARTHRITIS].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Prospective Studies; Rituximab; Treatment Outcome | 2017 |
IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Galactose; Glycosylation; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prognosis; Proteomics | 2017 |
Nonassociation of homocysteine gene polymorphisms with treatment outcome in South Indian Tamil Rheumatoid Arthritis patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Ferredoxin-NADP Reductase; Gene Frequency; Genetic Association Studies; Humans; India; Male; Methotrexate; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prospective Studies; Treatment Outcome | 2018 |
Reply.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2018 |
Reply.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2018 |
A rare case of pulmonary toxoplasmosis in a patient with undifferentiated inflammatory arthritis on chronic methotrexate and corticosteroid therapy.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Lung Diseases, Interstitial; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Toxoplasma; Toxoplasmosis; Trimethoprim, Sulfamethoxazole Drug Combination | 2017 |
Herpes Zoster and Tofacitinib: Clinical Outcomes and the Risk of Concomitant Therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Clinical Trials as Topic; Databases, Factual; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Herpes Zoster; Humans; Incidence; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Proportional Hazards Models; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors | 2017 |
A national survey of nurse training: Confidence and competence in educating patients commencing methotrexate therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Competence; Education, Nursing; Humans; Methotrexate; Nurses; Patient Education as Topic; Rheumatology; Surveys and Questionnaires | 2017 |
Methotrexate still works: comment on the articles by Rohr et al and Hirata et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2018 |
Effect of disease-modifying antirheumatic drug therapy on immune response to trivalent influenza vaccine in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Histocompatibility Antigens Class II; Humans; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged | 2017 |
Triple DMARD treatment in early rheumatoid arthritis modulates synovial T cell activation and plasmablast/plasma cell differentiation pathways.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroscopy; Biopsy; Case-Control Studies; Cell Differentiation; Down-Regulation; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Plasma Cells; Principal Component Analysis; Remission Induction; Sequence Analysis, RNA; Sulfasalazine; Synovial Membrane; T-Lymphocytes; Transcriptome | 2017 |
Trends in Treatment, Outcomes, and Incidence of Orthopedic Surgery in Patients with Rheumatoid Arthritis: An Observational Cohort Study Using the Japanese National Database of Rheumatic Diseases.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cross-Sectional Studies; Databases, Factual; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Orthopedic Procedures; Treatment Outcome | 2017 |
Optimal methotrexate dose is associated with better clinical outcomes than non-optimal dose in daily practice: results from the ESPOIR early arthritis cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2017 |
Utility of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as biomarker to predict therapeutic response to methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Sensitivity and Specificity; Surveys and Questionnaires; Triggering Receptor Expressed on Myeloid Cells-1; Young Adult | 2017 |
Reduction of methotrexate and glucocorticoids use after the introduction of biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis in daily practice based on the IORRA cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Administration Schedule; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged | 2018 |
B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; B-Lymphocyte Subsets; Biomarkers; Chemokine CXCL13; Follow-Up Studies; Gene Expression Profiling; Gene Expression Regulation; Humans; Immunoglobulin D; Immunologic Memory; Immunophenotyping; Lymphocyte Count; Methotrexate; Phenotype; Receptors, CXCR5; Receptors, IgE; Treatment Outcome; Tumor Necrosis Factor Receptor Superfamily, Member 7; Tumor Necrosis Factor-alpha | 2017 |
Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Body Composition; Body Mass Index; Bone Density; Cortical Bone; Female; Humans; Male; Methotrexate; Middle Aged; Muscle Strength; Muscle, Skeletal; Tomography, X-Ray Computed | 2017 |
MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression - First results of a cross-sectional study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Gingival Crevicular Fluid; Humans; Immunosuppressive Agents; Male; Matrix Metalloproteinase 8; Methotrexate; Middle Aged; Periodontal Index; Periodontitis; Tissue Inhibitor of Metalloproteinase-1 | 2019 |
Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Male; Methotrexate; Molecular Targeted Therapy; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Rats, Sprague-Dawley | 2017 |
Discussion of Methotrexate Dosage.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Methotrexate; Prednisone | 2018 |
Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Basilar Artery; Brain; Carotid Artery Diseases; Cerebrovascular Disorders; Female; Humans; Infliximab; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Middle Cerebral Artery; Ultrasonography; Ultrasonography, Doppler, Transcranial | 2017 |
Disease activity trajectories in early rheumatoid arthritis following intensive DMARD therapy over 3 years: association with persistence to therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Disease Progression; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Kaplan-Meier Estimate; Linear Models; Longitudinal Studies; Male; Medication Adherence; Methotrexate; Middle Aged; Multivariate Analysis; Remission Induction; Risk Factors; Sulfasalazine; Time Factors; Treatment Outcome | 2017 |
Further Treatment Intensification in Undifferentiated and Rheumatoid Arthritis Patients Already in Low Disease Activity has Limited Benefit towards Physical Functioning.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Treatment Outcome | 2017 |
Intra-articular methotrexate versus corticosteroid injections in medium-sized joints of rheumatoid arthritis patients-an intervention study.
Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Injections, Intra-Articular; Male; Methotrexate; Synovial Membrane; Synovitis; Treatment Outcome; Ultrasonography, Doppler | 2018 |
Serum sickness-like disease after switching to biosimilar infliximab.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Drug Substitution; Drug Therapy, Combination; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prednisone; Serum Sickness | 2017 |
Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Certolizumab Pegol; Female; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha; Wrist Joint | 2017 |
Response to eLetter: 'Discussion of methotrexate dosage' by Maguire
Topics: Arthritis, Rheumatoid; Follow-Up Studies; Humans; Methotrexate; Prednisone | 2018 |
Methotrexate-induced pneumonia: A dermatologist wake up call.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dermatologists; Humans; Methotrexate; Pneumonia | 2018 |
MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.
Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Ethnicity; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Replication Protein C | 2017 |
Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickness; Cholesterol; Cohort Studies; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Risk Factors; Single-Blind Method; Surveys and Questionnaires; Ultrasonography; Up-Regulation | 2017 |
Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hyperemia; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2017 |
A review of sarilumab for the treatment of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Neutropenia; Receptors, Interleukin-6 | 2018 |
A Bayesian model that jointly considers comparative effectiveness research and patients' preferences may help inform GRADE recommendations: an application to rheumatoid arthritis treatment recommendations.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Comparative Effectiveness Research; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Network Meta-Analysis; Patient Preference; Practice Guidelines as Topic; Sulfasalazine; Treatment Outcome | 2018 |
Polymorphic lymphoproliferative disorders in patients with rheumatoid arthritis are associated with a better clinical outcome.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Incidence; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Remission Induction | 2018 |
[Efficacy of internalized RGD-modified echogenic liposomes in diagnosis and treatment in a mouse model of rheumatoid arthritis].
Topics: Animals; Arthritis, Rheumatoid; Human Umbilical Vein Endothelial Cells; Humans; Indocyanine Green; Liposomes; Methotrexate; Mice; Oligopeptides; Particle Size; Ultrasonography | 2017 |
Pembrolizumab-associated inflammatory myopathy.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Fatal Outcome; Female; Humans; Melanoma; Methotrexate; Myositis | 2018 |
Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis.
Topics: Adult; Age Factors; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Chile; Female; Genotype; Humans; Indians, North American; Indians, South American; Isoxazoles; Leflunomide; Male; Methotrexate; Mexico; Middle Aged; Peru; Radiography; Rheumatoid Factor; Sex Factors; Sulfasalazine | 2017 |
Remission assessment of rheumatoid arthritis in daily practice in China: a cross-sectional observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; China; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Young Adult | 2018 |
Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cardiovascular Diseases; China; Comorbidity; Female; Fractures, Bone; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Neoplasms; Prevalence; Registries; Risk Factors | 2017 |
Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clofazimine; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Male; Methotrexate; Mycobacterium leprae; Retrospective Studies; Rifampin; Skin; Steroids; Thalidomide; United States | 2017 |
Dermatomyositis Complicated by Digital Ischemia and Lung Adenocarcinoma in a Patient with Positive Anti-signal Recognition Particle Antibodies.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anti-Inflammatory Agents; Antibodies; Arthritis, Rheumatoid; Asian People; Autoimmune Diseases; Dermatologic Agents; Dermatomyositis; Female; Humans; Ischemia; Lung Neoplasms; Methotrexate; Methylprednisolone; Middle Aged; Signal Recognition Particle; Sjogren's Syndrome; Treatment Outcome | 2018 |
Concordance and correlation of activity indices in patients with rheumatoid arthritis in northwestern Colombia: A cross-sectional study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Colombia; Cross-Sectional Studies; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Observer Variation; Predictive Value of Tests; Remission Induction; Reproducibility of Results; Severity of Illness Index; Treatment Outcome | 2018 |
Kaposiform hemangioendothelioma in an adult with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Hemangioendothelioma; Humans; Kasabach-Merritt Syndrome; Male; Methotrexate; Middle Aged; Sarcoma, Kaposi; Steroids | 2017 |
Tocilizumab potentially prevents bone loss in patients with anticitrullinated protein antibody-positive rheumatoid arthritis.
Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Collagen Type I; Drug Therapy, Combination; Female; Femur Neck; Gene Expression Regulation; Glucocorticoids; Humans; Interleukin-6; Lumbar Vertebrae; Male; Methotrexate; Middle Aged; Osteocalcin; Peptide Fragments; Peptides; Procollagen; Prospective Studies | 2017 |
Similar short-term clinical response to high-dose versus low-dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Linear Models; Male; Methotrexate; Middle Aged; Propensity Score; Surveys and Questionnaires; Treatment Outcome | 2017 |
Factors influencing spinal sagittal balance, bone mineral density, and Oswestry Disability Index outcome measures in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Cross-Sectional Studies; Disability Evaluation; Female; Glucocorticoids; Humans; Lordosis; Low Back Pain; Male; Methotrexate; Middle Aged; Osteoporosis; Outcome Assessment, Health Care; Pelvis; Posture; Quality of Life; Radiography; Risk Factors; Spinal Curvatures; Surveys and Questionnaires | 2018 |
Seropositivity of Rheumatoid Arthritis Specific Tests in a Patient With Nephrotic Syndrome: Successful Treatment With Rituximab.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Methotrexate; Nephrotic Syndrome; Predictive Value of Tests; Remission Induction; Rheumatoid Factor; Rituximab; Serologic Tests; Steroids; Treatment Outcome; Young Adult | 2017 |
Methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis.
Topics: Administration, Intravenous; Aftercare; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Lymphoproliferative Disorders; Methotrexate; Methylprednisolone; Middle Aged; Multiple Pulmonary Nodules; Sjogren's Syndrome; Treatment Outcome | 2017 |
A retrospective review of the persistence on bDMARDs prescribed for the treatment of rheumatoid arthritis in the Australian population.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Biological Products; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; National Health Programs; Retrospective Studies; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
[A methotrexate-associated lympholiferative disorder patient with gastrointestinal perforation].
Topics: Aged; Arthritis, Rheumatoid; Female; Gastrointestinal Diseases; Humans; Lymphoproliferative Disorders; Methotrexate | 2017 |
Safe Use of Rituximab in an Elderly Patient With Rheumatoid Arthritis and Severe Heart Failure.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Echocardiography; Hand Joints; Heart Failure; Humans; Male; Methotrexate; Radiography; Rituximab; Severity of Illness Index; Stroke Volume; Time; Treatment Outcome | 2018 |
Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
A surgical case of methotrexate-associated lymphomatoid granuloma.
Topics: Adenocarcinoma in Situ; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Lung Neoplasms; Lymphomatoid Granulomatosis; Methotrexate; Pneumonectomy; Tomography, X-Ray Computed | 2018 |
Outcomes after rheumatoid arthritis patients complete their participation in a long-term observational study with tofacitinib combined with methotrexate: practical and ethical implications in vulnerable populations after tofacitinib discontinuation.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Ethics, Research; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence; Remission Induction; Research Design; Research Subjects; Time Factors; Treatment Outcome; Vulnerable Populations | 2018 |
Relationship between disease activity and patient-reported outcomes in rheumatoid arthritis: Post hoc analyses of overall and Japanese results from two phase 3 clinical trials.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Quality of Life; Randomized Controlled Trials as Topic | 2018 |
Determinants of Patient's Global Assessment of Disease Activity and Physician's Global Assessment of Disease Activity in patients with rheumatoid arthritis: A post hoc analysis of overall and Japanese results from phase 3 clinical trials.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Reported Outcome Measures; Randomized Controlled Trials as Topic | 2018 |
Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder, Hodgkin Type, following Epstein-Barr Viral Hepatitis in a Patient with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Epstein-Barr Virus Infections; Hepatitis, Viral, Human; Hodgkin Disease; Humans; Iatrogenic Disease; Infliximab; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged | 2018 |
STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Female; Humans; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Middle Aged; Mutation; Red-Cell Aplasia, Pure; STAT3 Transcription Factor; Treatment Outcome | 2018 |
Bone-targeted methotrexate-alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo.
Topics: Alendronate; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Collagen; Cytokines; Drug Therapy, Combination; Female; Inflammation; Male; Methotrexate; Mice; Mice, Inbred C57BL; Muramidase; Osteoclasts; Osteogenesis; Rats; Rats, Wistar | 2018 |
[Cutaneous lymphoma associated with methotrexate in a patient with rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoma, B-Cell; Male; Methotrexate; Skin Neoplasms | 2018 |
Long-term efficacy and safety of add-on tacrolimus for persistent, active rheumatoid arthritis despite treatment with methotrexate and tumor necrosis factor inhibitors.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Tacrolimus; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
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Topics: Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Fluorodeoxyglucose F18; Glucocorticoids; Humans; Male; Methotrexate; Positron Emission Tomography Computed Tomography; Sodium Fluoride | 2018 |
Iguratimod is effective in refractory rheumatoid arthritis patients with inadequate response to methotrexate-cyclosporin A-hydroxychloroquine-prednisone.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Cyclosporine; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Sulfonamides; Treatment Outcome | 2018 |
Cerebral Toxoplasmosis Diagnosed by Nested-polymerase Chain Reaction in a Patient with Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; DNA, Ribosomal; Female; Humans; Immunosuppressive Agents; Methotrexate; Polymerase Chain Reaction; Toxoplasma; Toxoplasmosis, Cerebral; Trimethoprim, Sulfamethoxazole Drug Combination; Withholding Treatment | 2018 |
Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disability Evaluation; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2018 |
Circulating serum interleukin-6, serum chitinase-3-like protein-1, and plasma vascular endothelial growth factor are not predictive for remission and radiographic progression in patients with early rheumatoid arthritis: post-hoc explorative and validation
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chitinase-3-Like Protein 1; Cyclosporine; Disease Progression; Female; Forefoot, Human; Hand Joints; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index; Vascular Endothelial Growth Factor A | 2018 |
Methotrexate Aspasomes Against Rheumatoid Arthritis: Optimized Hydrogel Loaded Liposomal Formulation with In Vivo Evaluation in Wistar Rats.
Topics: Administration, Cutaneous; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Carriers; Drug Compounding; Drug Evaluation, Preclinical; Hydrogel, Polyethylene Glycol Dimethacrylate; Liposomes; Male; Methotrexate; Particle Size; Rats; Rats, Wistar; Skin Absorption | 2018 |
Methotrexate might reduce ischemic stroke in patients with rheumatoid arthritis: a population-based retrospective cohort study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Hydroxychloroquine; Incidence; Male; Methotrexate; Middle Aged; Protective Factors; Retrospective Studies; Risk Factors; Stroke; Sulfasalazine; Taiwan; Treatment Outcome | 2018 |
[Rheumatoid arthritis and polycythemia vera JAK2 negative association: Polycythemia may be worsening under methotrexate?]
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase 2; Male; Methotrexate; Polycythemia Vera; Sulfasalazine | 2018 |
Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biomarkers; Chromosomes, Human; Cohort Studies; Humans; Logistic Models; Methotrexate; Quantitative Trait Loci; Reproducibility of Results | 2018 |
Long-term disease and patient-reported outcomes of a continuous treat-to-target approach in patients with early rheumatoid arthritis in daily clinical practice.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Quality of Life; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Early macular toxicity following 2 months of hydroxychloroquine therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Macula Lutea; Methotrexate; Middle Aged; Retinal Diseases; Tomography, Optical Coherence | 2018 |
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
Topics: Adenosine Triphosphate; Adult; Aged; Antigens, CD; Antirheumatic Agents; Apyrase; Arthritis, Rheumatoid; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Drug Resistance; Female; Gene Expression Regulation; Gene Frequency; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Smad2 Protein; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2018 |
Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Methotrexate; Mice; Signal Transduction; Synovial Fluid; Toll-Like Receptors; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha | 2018 |
Immunogenicity and persistence of a prime-boost re-vaccination strategy for pneumococcal vaccines in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Bacterial; Arthritis, Rheumatoid; Female; Humans; Immunization Schedule; Immunoassay; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Streptococcus pneumoniae | 2018 |
Suppression of infliximab antibody levels by azathioprine in patients with rheumatoid arthritis.
Topics: Adult; Antibodies; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Infliximab; Methotrexate | 2017 |
Does daily folic acid supplementation reduce methotrexate efficacy?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Dermatologic Agents; Drug Antagonism; Folic Acid; Humans; Methotrexate; Psoriasis | 2017 |
Brentuximab vedotin is effective for rheumatoid arthritis in a patient with relapsed methotrexate-associated Hodgkin lymphoma.
Topics: Arthritis, Rheumatoid; Brentuximab Vedotin; Female; Hodgkin Disease; Humans; Immunoconjugates; Methotrexate; Middle Aged | 2018 |
Activation status of peripheral blood neutrophils and the complement system in adult rheumatoid arthritis patients undergoing combined therapy with infliximab and methotrexate.
Topics: Adult; Antibodies, Monoclonal; Antigen-Antibody Complex; Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Complement Activation; Female; Humans; Infliximab; Methotrexate; Middle Aged; Neutrophils; Reactive Oxygen Species | 2018 |
Methotrexate-induced lymphoproliferative disorders: regression matters.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate | 2018 |
Cost-Effectiveness Analysis of Abatacept Compared with Adalimumab on Background Methotrexate in Biologic-Naive Adult Patients with Rheumatoid Arthritis and Poor Prognosis.
Topics: Abatacept; Adalimumab; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prognosis; Quality-Adjusted Life Years | 2018 |
Perforation in Submucous Cleft Palate Due to Methotrexate-Induced Mucositis in a Patient With Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cleft Palate; Female; Humans; Methotrexate; Mouth Mucosa; Mucositis; Rupture, Spontaneous; Tomography, X-Ray Computed | 2018 |
Pharmacological characterisation of CR6086, a potent prostaglandin E
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclic AMP; Cytokines; Disease Models, Animal; Drug Therapy, Combination; HEK293 Cells; Humans; Macrophages; Male; Methotrexate; Mice, Inbred DBA; Radioligand Assay; Rats, Inbred Lew; Receptors, Prostaglandin E, EP4 Subtype; THP-1 Cells; Vascular Endothelial Growth Factor A | 2018 |
Adult T-cell Leukemia/Lymphoma as a Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Human T-lymphotropic virus 1; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Receptors, Interleukin-2 | 2018 |
Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Bisphosphonate-Associated Osteonecrosis of the Jaw; Diphosphonates; Female; Humans; Methotrexate; Middle Aged; Risk Factors; Tooth Extraction | 2018 |
Evaluation of a clinical pharmacogenetics model to predict methotrexate response in patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Treatment Outcome | 2018 |
Choledochoduodenal Fistula during Chemotherapy with Brentuximab Vedotin for Methotrexate-associated Lymphoproliferative Disorder.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Brentuximab Vedotin; Humans; Immunoconjugates; Jaundice, Obstructive; Lymphoproliferative Disorders; Male; Methotrexate | 2018 |
Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Biological Products; Female; Follow-Up Studies; Glucocorticoids; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Patient Reported Outcome Measures; Prospective Studies; Risk Factors; Self Report; Severity of Illness Index; Surveys and Questionnaires; Symptom Flare Up; Tertiary Care Centers | 2018 |
Predictors of hypogammaglobulinemia during rituximab maintenance therapy in rheumatoid arthritis: A 12-year longitudinal multi-center study.
Topics: Adult; Agammaglobulinemia; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; gamma-Globulins; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Risk Factors; Rituximab | 2018 |
Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like synoviocytes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Interleukin-1beta; Methotrexate; Platelet-Derived Growth Factor; Synoviocytes | 2018 |
Efficacy and safety of golimumab as add-on therapy to standard disease-modifying antirheumatic drugs: Results of the GO-MORE study in the Polish population.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Poland; Prospective Studies; Treatment Outcome | 2018 |
Therapy: Arming the regulators - new strategies to treat autoimmunity.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Humans; Methotrexate | 2018 |
Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts.
Topics: Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Circadian Clocks; Circadian Rhythm; Collagen Type XI; Dose-Response Relationship, Drug; Female; Fibroblasts; Humans; Male; Methotrexate; Middle Aged; Nuclear Proteins; RNA-Binding Proteins; Synovial Membrane; Transcription Factors | 2018 |
Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Retrospective Studies; Treatment Outcome | 2018 |
Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways?
Topics: Arthritis, Rheumatoid; Haplotypes; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precision Medicine | 2018 |
Factors affecting walking ability in female patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; C-Reactive Protein; Female; Gait; Humans; Knee; Linear Models; Methotrexate; Middle Aged; Risk Factors; Severity of Illness Index; Walking Speed | 2018 |
Rheumatoid Arthritis Magnetic Resonance Imaging Score Predicts Therapy Response: Results of the German ArthroMark Cohort.
Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Germany; Hand; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Rheumatoid Factor; Severity of Illness Index | 2018 |
Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Inflammation Mediators; Knee Joint; Male; Matrix Metalloproteinase Inhibitors; Methotrexate; Mice; Quercetin | 2018 |
Successful Use of a Reduced Dose Regimen of Rituximab in a Case of Rheumatoid Arthritis with Raynaud's Syndrome.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunologic Tests; Male; Methotrexate; Patient Acuity; Pleural Effusion; Prednisone; Radiography; Raynaud Disease; Remission Induction; Rituximab; Thoracentesis; Treatment Outcome; Ultrasonography | 2018 |
Initiation of Disease-Modifying Therapies in Rheumatoid Arthritis Is Associated With Changes in Blood Pressure.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Pressure; Female; Humans; Hydroxychloroquine; Hypertension; Incidence; Leflunomide; Linear Models; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Sulfasalazine; Tumor Necrosis Factor Inhibitors | 2018 |
No increased risk of herpes zoster in TNF inhibitor and non-TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Female; Herpes Zoster; Humans; Immunocompromised Host; Incidence; Japan; Male; Methotrexate; Middle Aged; Opportunistic Infections; Retrospective Studies; Risk Factors; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Prediction of response to methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2018 |
Circulating miR-10a as Predictor of Therapy Response in Rheumatoid Arthritis Patients Treated with Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Predictive Value of Tests; ROC Curve; Treatment Outcome | 2018 |
Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway.
Topics: Apoptosis; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclophosphamide; Drug Resistance, Multiple; Drug Therapy, Combination; Fibroblasts; Gene Expression Regulation; Humans; Janus Kinase 2; Methotrexate; Signal Transduction; STAT3 Transcription Factor; Synoviocytes | 2018 |
Why subcutaneous methotrexate should be a prerequisite to biologic use in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2019 |
Notch-1 siRNA and Methotrexate towards a Multifunctional Approach in Rhematoid Arthritis Management: a Nanomedicine Approach.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Disease Models, Animal; Drug Carriers; Drug Compounding; Ethylene Oxide; Genetic Therapy; Human Umbilical Vein Endothelial Cells; Humans; Lactones; Methotrexate; Mice; Micelles; Nanomedicine; Polyesters; Polyethylene Glycols; Polyethyleneimine; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Receptor, Notch1; RNA, Small Interfering; Signal Transduction; Synoviocytes; Treatment Outcome | 2018 |
Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Combinations; Etanercept; Female; Humans; Immunosuppressive Agents; Injections, Subcutaneous; Intensive Care Units; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Radiography, Thoracic; Respiration, Artificial; Respiratory Insufficiency; Sputum; Steroids; Tomography, X-Ray Computed; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2018 |
Can a disaster affect rheumatoid arthritis status? A retrospective cohort study after the 2011 triple disaster in Fukushima, Japan.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Continuity of Patient Care; Disease Progression; Earthquakes; Female; Fukushima Nuclear Accident; Humans; Japan; Logistic Models; Male; Medical Records; Methotrexate; Middle Aged; Prognosis; Radiation Exposure; Residence Characteristics; Retrospective Studies; Risk Factors; Time Factors; Tsunamis | 2018 |
SLC04A1, SLC22A2 and SLC28A2 variants not related to methotrexate efficacy or toxicity in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genotype; Humans; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Organic Anion Transporters; Organic Cation Transporter 2; Pharmacogenetics; Polymorphism, Single Nucleotide; Regression Analysis; Severity of Illness Index; Treatment Outcome | 2018 |
The prognostic value of positron emission tomography/computed tomography in rheumatoid arthritis patients with methotrexate-associated lymphoproliferative disorders.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Multimodal Imaging; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Prognosis; Retrospective Studies | 2018 |
Japan College of Rheumatology guideline for the use of methotrexate in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Japan; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis; Risk Adjustment; Treatment Outcome | 2019 |
Factors associated with physicians' prescriptions for rheumatoid arthritis drugs not filled by patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Patient Compliance; Physicians; Piperidines; Prescriptions; Pyrimidines; Pyrroles; Risk Factors | 2018 |
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; Gene Expression Profiling; Genetic Predisposition to Disease; Humans; In Situ Hybridization, Fluorescence; Lymphocytes, Tumor-Infiltrating; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Methotrexate; Middle Aged; Oligonucleotide Array Sequence Analysis; Phenotype; Transcriptome; Tumor Microenvironment | 2018 |
Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Ferredoxin-NADP Reductase; Gene Frequency; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Severity of Illness Index; Treatment Outcome; White People | 2018 |
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis: A Very Rare Case.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Neoplasm Recurrence, Local; Rare Diseases; Rituximab; Sulfonamides; Treatment Outcome | 2018 |
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Male; Methotrexate; Mice; Monocytes; Purines; Synovial Fluid | 2018 |
Comparison of Adults With Polyarticular Juvenile Idiopathic Arthritis to Adults With Rheumatoid Arthritis: A Cross-sectional Analysis of Clinical Features and Medication Use.
Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Cross-Sectional Studies; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Peptides, Cyclic; Rheumatoid Factor; Symptom Assessment; Tumor Necrosis Factor-alpha; United States | 2019 |
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12 | 2018 |
Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis.
Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Denmark; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Registries | 2018 |
Long-term deterioration of interstitial lung disease in patients with rheumatoid arthritis treated with abatacept.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2019 |
Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate.
Topics: Alkaline Phosphatase; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Drug Therapy, Combination; Liver; Macrophages; Male; Methotrexate; Positron Emission Tomography Computed Tomography; Rats, Wistar; Recombinant Proteins; Spleen; Synovial Membrane; Tissue Distribution | 2018 |
Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclophosphamide; Drug Therapy, Combination; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Interleukin-6; Janus Kinase 2; Methotrexate; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor; Synoviocytes; Tyrphostins | 2018 |
Methotrexate: who would have predicted its importance in rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Forecasting; Humans; Methotrexate | 2018 |
Disease Characteristics and Change in Arthritis Activity according to Treatment in Hepatitis B Surface Antigen-positive Rheumatoid Arthritis Patients: a Retrospective Chart Review Study.
Topics: Adult; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Female; Hepatitis B; Hepatitis B Surface Antigens; Humans; Joints; Male; Methotrexate; Middle Aged; Odds Ratio; Regression Analysis; Retrospective Studies; Severity of Illness Index; Sulfasalazine | 2018 |
Methotrexate-associated lymphoproliferative disorder presenting as giant ulcers on the leg.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Leg Ulcer; Lymphoproliferative Disorders; Methotrexate | 2018 |
Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line; Drug Resistance; Female; Lipids; Methotrexate; Mice, Inbred C57BL; Nanoparticles; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2018 |
Accelerated subcutaneous nodulosis in patients with rheumatoid arthritis treated with tocilizumab: a case series.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Nodule | 2018 |
Severe bone marrow suppression due to methotrexate toxicity following aceclofenac-induced acute kidney injury.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Cells; Bone Marrow Diseases; Diclofenac; Drug Therapy, Combination; Fatal Outcome; Female; Humans; Methotrexate; Oral Ulcer | 2018 |
The role of concomitant methotrexate dosage and maintenance over time in the therapy of rheumatoid arthritis patients treated with adalimumab or etanercept: retrospective analysis of a local registry.
Topics: Adalimumab; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Etanercept; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Retrospective Studies; Time Factors | 2018 |
Differences in clinical Pneumocystis pneumonia in rheumatoid arthritis and other connective tissue diseases suggesting a rheumatoid-specific interstitial lung injury spectrum.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; beta-Glucans; Connective Tissue Diseases; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis; Tomography, X-Ray Computed; Treatment Outcome | 2018 |
Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Inflammation; Methotrexate; Phenotype; Piperidines; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Signal Transduction | 2018 |
Effect of anti-rheumatic treatment on selenium levels in inflammatory arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Selenium; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
An Economic Evaluation of Tofacitinib Treatment in Rheumatoid Arthritis After Methotrexate or After 1 or 2 TNF Inhibitors from a U.S. Payer Perspective.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Decision-Making; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Drug Costs; Drug Substitution; Humans; Methotrexate; Models, Economic; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United States | 2018 |
Sex-associated Treatment Differences and Their Outcomes in Rheumatoid Arthritis: Results from the METEOR Register.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Hydroxychloroquine; Linear Models; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Sex Factors; Sulfasalazine; Treatment Outcome | 2018 |
Methotrexate-associated lymphoproliferative disorder complicated by severe acute respiratory failure and ileal perforation:a case report.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Ileal Diseases; Intestinal Perforation; Lymphoproliferative Disorders; Methotrexate; Respiratory Insufficiency | 2018 |
Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cell-Penetrating Peptides; Drug Carriers; Folic Acid; Hydrogen-Ion Concentration; Lactic Acid; Lipids; Male; Methotrexate; Mice; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Stearic Acids | 2018 |
Effectiveness of biologics in Australian patients with rheumatoid arthritis: a large observational study: REAL.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Biological Products; Databases, Factual; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2018 |
Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, T-Cell; Lymphomatoid Granulomatosis; Male; Methotrexate; Neoplasms, Second Primary | 2019 |
Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Treatment Outcome; United Kingdom | 2018 |
An Observational Study of Cardiovascular Risks Associated with Rheumatoid Arthritis Therapies: A Comparison of Two Analytical Approaches.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Regression Analysis; Risk Factors; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Blood Proteins; Case-Control Studies; Cell Count; Gene Expression Regulation; Humans; Infliximab; Lymphocytes; Methotrexate; Monocytes; Neutrophils; Proteomics; Remission Induction; Severity of Illness Index; Transcriptome; Treatment Outcome | 2018 |
Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.
Topics: Adult; Alleles; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Female; Folic Acid; gamma-Glutamyl Hydrolase; Genotype; Humans; India; Logistic Models; Male; Methotrexate; Middle Aged; Odds Ratio; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Prospective Studies; Replication Protein C | 2018 |
How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis?
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Management; Female; Folic Acid; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pancytopenia; Retrospective Studies; Rheumatology | 2018 |
Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Calcium Phosphates; Drug Liberation; Folate Receptor 2; Folic Acid; Genetic Therapy; Humans; Liposomes; Methotrexate; Mice; Molecular Targeted Therapy; Nanoparticles; NF-kappa B; Particle Size; Rats; RAW 264.7 Cells; RNA, Small Interfering | 2018 |
In-stent Restenosis after Drug-eluting Stent Implantation in Rheumatoid Arthritis: Possible Protective Effect of Methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Methotrexate; Middle Aged; Percutaneous Coronary Intervention; Treatment Outcome | 2018 |
[Primary central nervous system methotrexate associated lymphoproliferative disorders in a patient with rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brain Neoplasms; Etanercept; Fatal Outcome; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2018 |
Unmet needs in the treatment of rheumatoid arthritis. An observational study and a real-life experience from a single university center.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Health Services Needs and Demand; Humans; Infliximab; Male; Methotrexate; Middle Aged | 2019 |
Rheumatoid arthritis revealed by polyadenopathy, diarrhea and digestive AA amyloidosis.
Topics: Amyloidosis; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biopsy, Needle; Diagnosis, Differential; Diarrhea; Digestive System Diseases; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lymphadenopathy; Methotrexate; Prednisone; Serum Amyloid A Protein; Tomography, X-Ray Computed; Treatment Outcome | 2019 |
The three-year efficacy of iguratimod in clinical daily practice in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Sulfonamides | 2019 |
Transient Elastography for Monitoring for Hepatotoxicity in Rheumatoid Arthritis Patients on Long-term Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Humans; Methotrexate | 2021 |
Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Non-alcoholic Fatty Liver Disease; Risk Factors; Transaminases | 2018 |
Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Hepatocellular; Disease Progression; Female; Humans; Immunosuppressive Agents; Liver Neoplasms; Methotrexate | 2019 |
Methotrexate intoxication: Beyond the adverse events.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Communicable Diseases; Dose-Response Relationship, Drug; Drug Interactions; Female; Fever; Humans; Male; Medication Errors; Methotrexate; Middle Aged; Mucositis; Purpura, Thrombocytopenic; Renal Insufficiency; Retrospective Studies; Risk Assessment; Risk Factors; Turkey | 2018 |
CD39 positive regulatory T cell frequency as a biomarker of treatment response to methotrexate in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Apyrase; Arthritis, Rheumatoid; Biomarkers, Pharmacological; CD4 Lymphocyte Count; Drug Monitoring; Female; Flow Cytometry; Humans; Male; Methotrexate; Middle Aged; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; T-Lymphocytes, Regulatory; Treatment Outcome | 2018 |
Adding baseline protein biomarkers to clinical predictors does not enhance prediction of treatment response to a methotrexate strategy in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Decision Support Techniques; Female; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Reproducibility of Results; Risk Assessment; Severity of Illness Index; Treatment Outcome; Vascular Cell Adhesion Molecule-1 | 2019 |
[112th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Invited Lecture: Progress in Rheumatoid Arthritis Therapy and Future Perspective].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Humans; Methotrexate; Precision Medicine; Remission Induction | 2015 |
Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Gastrointestinal Diseases; Humans; Japan; Male; Methotrexate; Middle Aged; Prevalence; Quality of Life; Risk Factors; Time Factors; Treatment Outcome | 2019 |
Methotrexate-related lymphoproliferative disorder of the lumbar spine origin presenting with severe low-back pain: case report.
Topics: Aged; Arthritis, Rheumatoid; Back Pain; Female; Humans; Lumbar Vertebrae; Lumbosacral Region; Lymphoproliferative Disorders; Methotrexate; Spinal Neoplasms | 2018 |
Factors Predicting the Therapeutic Response to Methotrexate in Japanese Patients with Rheumatoid Arthritis: A Hospital-Based Cohort Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cohort Studies; Female; Genotype; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2018 |
Co-Delivery of Teriflunomide and Methotrexate from Hydroxyapatite Nanoparticles for the Treatment of Rheumatoid Arthritis: In Vitro Characterization, Pharmacodynamic and Biochemical Investigations.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Crotonates; Drug Carriers; Drug Combinations; Drug Compounding; Drug Liberation; Drug Stability; Durapatite; Female; Hydrogen-Ion Concentration; Hydroxybutyrates; Kinetics; Methotrexate; Nanoparticles; Nitriles; Oxidative Stress; Particle Size; Rats; Rats, Wistar; Tissue Distribution; Toluidines | 2018 |
The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prospective Studies; Regression Analysis; Time Factors; Treatment Outcome | 2019 |
Autoantibody status is not associated with early treatment response to first-line methotrexate in patients with early rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Databases, Factual; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 2019 |
Treat to target strategy in early rheumatoid arthritis versus routine care - A comparative clinical practice study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Registries; Remission Induction; Severity of Illness Index; Treatment Outcome | 2019 |
Comparative effectiveness of first-line biological monotherapy use in rheumatoid arthritis: a retrospective analysis of the RECord-linkage On Rheumatic Diseases study on health care administrative databases.
Topics: Abatacept; Adalimumab; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Comorbidity; Comparative Effectiveness Research; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Infliximab; Leflunomide; Male; Medical Record Linkage; Methotrexate; Middle Aged; Retrospective Studies; Time Factors; Treatment Failure | 2018 |
An Analysis of the Biological Disease-modifying Antirheumatic Drug-free Condition of Adalimumab-treated Rheumatoid Arthritis Patients.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2019 |
Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; Male; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2019 |
Effects of a 15-month anti-TNF-α treatment on plasma levels of glycosaminoglycans in women with rheumatoid arthritis.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Certolizumab Pegol; Drug Therapy, Combination; Etanercept; Female; Glycosaminoglycans; Humans; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2018 |
Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Databases, Factual; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; France; Humans; Logistic Models; Male; Medication Errors; Methotrexate; Middle Aged; Multivariate Analysis; Pharmacovigilance; Poison Control Centers; Risk Assessment; Sex Factors; Survival Rate | 2019 |
Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS).
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Chromatography, Liquid; Cytokines; Inflammation; Male; Metabolomics; Methotrexate; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Biologic and Glucocorticoid Use after Methotrexate Initiation in Patients with Rheumatoid Arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Comorbidity; Databases, Factual; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; United States | 2019 |
Chronic lung disease in U.S. Veterans with rheumatoid arthritis and the impact on survival.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Chronic Disease; Female; Humans; Longitudinal Studies; Lung Diseases; Male; Methotrexate; Middle Aged; Multivariate Analysis; Registries; Risk Factors; Severity of Illness Index; Survival Analysis; United States; Veterans | 2018 |
[Chinese expert-based consensus for methotrexate in rheumatic diseases].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Consensus; Humans; Methotrexate; Rheumatic Diseases; Rheumatology | 2018 |
Risk for Herpes Zoster in Tofacitinib-Treated Rheumatoid Arthritis Patients With and Without Concomitant Methotrexate and Glucocorticoids.
Topics: Aged; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Herpes Zoster; Humans; Incidence; Janus Kinase Inhibitors; Male; Medicare; Methotrexate; Middle Aged; Multivariate Analysis; Piperidines; Pyrimidines; Pyrroles; Risk Assessment; Time Factors; United States | 2019 |
Risk factors associated with inadequate control of disease activity in elderly patients with rheumatoid arthritis: Results from a nationwide KOrean College of Rheumatology BIOlogics (KOBIO) registry.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Republic of Korea; Risk Factors; Severity of Illness Index | 2018 |
How to treat patients with rheumatoid arthritis when methotrexate has failed? The use of a multiple propensity score to adjust for confounding by indication in observational studies.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Protocols; Drug Substitution; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Methotrexate; Middle Aged; Observational Studies as Topic; Patient Selection; Propensity Score; Registries; Treatment Outcome | 2019 |
Factors associated with long-term retention of treatment with golimumab in a real-world setting: an analysis of the Spanish BIOBADASER registry.
Topics: Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Proportional Hazards Models; Registries; Retrospective Studies; Spain; Spondylarthropathies; Tumor Necrosis Factor Inhibitors | 2019 |
Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Adhesion; Cells, Cultured; Collagen; Fibronectins; Humans; Integrin alpha2beta1; Laminin; Lymphocyte Activation; Methotrexate; Protective Agents; Signal Transduction; Th17 Cells | 2018 |
[Diagnosing and treating rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate; Osteoporosis | 2018 |
Piggybacked by PEGylation?
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Polyethylene Glycols | 2018 |
The effect of methotrexate versus other disease-modifying anti-rheumatic drugs on serum drug levels and clinical response in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors.
Topics: Adalimumab; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Logistic Models; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Metering the METEOR in methotrexate failure: is propensity score a falling star?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Propensity Score | 2019 |
Anti-TNF and Physiologic Measures of Metabolic Disease in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Databases, Factual; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Risk Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2019 |
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis.
Topics: Adalimumab; Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors | 2019 |
"Methotrexate and NSAIDs in rheumatoid arthritis-Confirmation of a known NSAIDs adverse effect rather than a dangerous combination".
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2018 |
Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Collagen; Cytokines; Female; Humans; Inflammation; Losartan; Male; Methotrexate; Middle Aged; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes | 2019 |
Response to: 'Metering the METEOR in methotrexate failure: is propensity score a falling star?' by Ahmed
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Propensity Score | 2019 |
Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Female; Humans; In Situ Hybridization; Lymphoma, B-Cell, Marginal Zone; Lymphoproliferative Disorders; Methotrexate; Stomach; Stomach Neoplasms; Stomach Ulcer | 2018 |
Associations Between Methotrexate Use and the Risk of Cardiovascular Events in Patients with Elderly-onset Rheumatoid Arthritis.
Topics: Age Distribution; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Confidence Intervals; Databases, Factual; Female; Geriatric Assessment; Humans; Incidence; Male; Methotrexate; Ontario; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Sex Distribution | 2019 |
Cardiac involvement of malignant lymphoma presenting intra-ventricular-wall nodules.
Topics: Abdominal Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Female; Heart Failure; Heart Neoplasms; Heart Ventricles; Humans; Lymph Nodes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Prednisolone; Tomography, X-Ray Computed; Vincristine | 2019 |
Association of Baseline Peptidylarginine Deiminase 4 Autoantibodies With Favorable Response to Treatment Escalation in Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prognosis; Protein-Arginine Deiminase Type 4; Sulfasalazine; Treatment Outcome | 2019 |
Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Management; Drug Therapy, Combination; Female; Health Services Needs and Demand; Humans; Male; Methotrexate; Middle Aged; Registries; Treatment Outcome | 2019 |
MicroRNA-132, miR-146a, and miR-155 as potential biomarkers of methotrexate response in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Prognosis; ROC Curve; Treatment Outcome | 2019 |
Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autophagosomes; Autophagy; Biological Therapy; Etanercept; Female; Humans; Inflammation; Male; Methotrexate; Microtubule-Associated Proteins; Middle Aged; Pilot Projects; Prospective Studies; Receptors, Interleukin-6; Sequestosome-1 Protein; Tumor Necrosis Factor-alpha | 2018 |
TNFα expressed on the surface of microparticles modulates endothelial cell fate in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Autophagy; Cell Line; Cell-Derived Microparticles; Endothelial Cells; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2018 |
Risk of malignant lymphoma in patients with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs and methotrexate
.
Topics: Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Humans; Infliximab; Japan; Lymphoma; Methotrexate; United States | 2019 |
Can metabolomic profiling predict response to therapy?
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Humans; Metabolome; Metabolomics; Methotrexate; Systems Biology | 2019 |
Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Cohort Studies; Female; Folic Acid; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Risk Factors; ROC Curve; Treatment Outcome | 2018 |
Association between cumulative methotrexate dose, non-invasive scoring system and hepatic fibrosis detected by Fibroscan in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Liver Cirrhosis; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Etanercept; Female; Humans; Jordan; Lebanon; Male; Methotrexate; Middle Aged; Odds Ratio; Qatar; Saudi Arabia; United Arab Emirates | 2018 |
Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Rheumatoid; Freund's Adjuvant; Humans; Indoles; Interleukin-6; Liver; Male; Methotrexate; Plant Extracts; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2018 |
TNF-α inhibitor-induced psoriasis: A decade of experience at the Cleveland Clinic.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Cyclosporine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Recurrence; Retrospective Studies; Risk Factors; Sex Factors; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2020 |
Association of C35T polymorphism in dihydrofolate reductase gene with toxicity of methotrexate in rheumatoid arthritis patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Genotype; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Treatment Outcome; Young Adult | 2019 |
The importance of inhibition of a catabolic pathway of methotrexate metabolism in its efficacy for rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Male; Methotrexate; Osteoporosis; Purines; Raloxifene Hydrochloride; Rats; Rats, Inbred Lew; Treatment Outcome | 2019 |
Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis.
Topics: Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Cell Differentiation; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Methotrexate | 2018 |
Catching the falling star: points to consider when using propensity scores.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Propensity Score | 2020 |
Response to: 'Catching the falling star: points to consider when using propensity scores' by Ouyang
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Propensity Score | 2020 |
EBV-positive mucocutaneous ulcer arising in rheumatoid arthritis patients treated with methotrexate: Single center series of nine cases.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunohistochemistry; Immunosuppressive Agents; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Mouth Mucosa; Rituximab; Treatment Outcome; Ulcer | 2019 |
Profiling of Gene Expression Biomarkers as a Classifier of Methotrexate Nonresponse in Patients With Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gene Expression Profiling; Gene Regulatory Networks; Humans; Interferon Type I; Male; Methotrexate; Middle Aged; Signal Transduction; Transcriptome; Treatment Failure | 2019 |
Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients.
Topics: Adult; AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Combinations; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Multienzyme Complexes; Nucleotide Deaminases; Pharmacogenomic Testing; Pyrophosphatases; Treatment Outcome | 2019 |
Combination leflunomide and methotrexate impedes the recovery of liver fibrosis, partly through inhibition of myeloid cell admittance.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen Type III; Collagen Type IV; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Female; Hepatic Stellate Cells; Humans; Hyaluronic Acid; Laminin; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Mice; Monocytes; Myeloid Cells; Vascular Endothelial Growth Factor A | 2019 |
The value of the simplified RAMRIS-5 in early RA patients under methotrexate therapy using high-field MRI.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hand Joints; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged | 2019 |
2017 recommendations of the Brazilian Society of Rheumatology for the pharmacological treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Decision Making; Drug Substitution; Drug Therapy, Combination; Glucocorticoids; Humans; Hydroxychloroquine; Leflunomide; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Rheumatology; Societies, Medical; Sulfasalazine | 2018 |
Highly aggressive plasmablastic neoplasms in patients with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Methotrexate; Multiple Myeloma; Plasmablastic Lymphoma | 2019 |
Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs.
Topics: Aged; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Autophagy; Cells, Cultured; Etanercept; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Tumor Necrosis Factor-alpha | 2019 |
The Atypical Presentation of Rheumatoid Arthritis in an Elderly Woman: A Case Report.
Topics: Aged; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Knee Joint; Methotrexate; Prednisolone; Radiography; Rheumatoid Factor | 2019 |
Efficacy and tolerability of abatacept treatment: results of 12 months observation.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Methotrexate; Middle Aged; Treatment Outcome | 2018 |
DICER and DROSHA gene expression in peripheral mononuclear blood cells from rheumatoid arthritis patients under methotrexate therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; DEAD-box RNA Helicases; Gene Expression; Humans; Leukocytes, Mononuclear; Methotrexate; Middle Aged; Ribonuclease III; RNA, Messenger | 2018 |
Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Respiratory Sounds | 2019 |
Synergistic enhancement and hepatoprotective effect of combination of total phenolic extracts of Citrus aurantium L. and methotrexate for treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cattle; Citrus; Drug Therapy, Combination; Fruit; Fruit and Vegetable Juices; Male; Methotrexate; Rats; Rats, Sprague-Dawley | 2019 |
Assessment of the adherence to disease-modifying drugs in patients with chronic inflammatory rheumatic diseases: Results of a survey of 1594 patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chronic Disease; Cross-Sectional Studies; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Surveys and Questionnaires | 2019 |
Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphadenopathy; Lymphoproliferative Disorders; Male; Methotrexate; Multiple Pulmonary Nodules; Neck; Tomography, X-Ray Computed | 2019 |
Cotreatment with methotrexate in routine care patients with rheumatoid arthritis receiving biological treatment yields better outcomes over time.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2019 |
miRNA-24 Gene Sequence, DHFR -829C-T Genotypes, and Methotrexate Response in Mexican Patients with Rheumatoid Arthritis.
Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Mexico; MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase | 2019 |
Real-world effectiveness and safety of rituximab in the treatment of rheumatoid arthritis: A single-center experience in Taiwan.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Risk Assessment; Risk Factors; Rituximab; Severity of Illness Index; Taiwan; Time Factors; Treatment Outcome | 2019 |
Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Marrow Diseases; Edema; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Synovitis; Tomography, X-Ray Computed; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2019 |
Early arthritis clinic is effective for rheumatoid and psoriatic arthritides.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Products; Early Medical Intervention; Female; Humans; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Severity of Illness Index; Sulfasalazine; Time-to-Treatment; Treatment Outcome; Young Adult | 2019 |
Predictors of abatacept retention over 2 years in patients with rheumatoid arthritis: results from the real-world ACTION study.
Topics: Abatacept; Adrenal Cortex Hormones; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Humans; Internationality; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Rheumatoid Factor; Treatment Outcome | 2019 |
Retention of tocilizumab with and without methotrexate during maintenance therapy for rheumatoid arthritis: the ACTRA-RI cohort study.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Registries; Remission Induction; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2019 |
Pulmonary Nodules in a Patient Treated With Methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Multiple Pulmonary Nodules | 2021 |
Genetic and epigenetic alteration of the programmed cell death 1 in rheumatoid arthritis.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Odds Ratio; Polymorphism, Single Nucleotide; Programmed Cell Death 1 Receptor; Reverse Transcriptase Polymerase Chain Reaction; Rheumatoid Factor; RNA, Messenger; Sulfasalazine; Transcriptome; Treatment Failure; Treatment Outcome | 2019 |
SEAM-PsA: Seems Like Methotrexate Works in Psoriatic Arthritis?
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Etanercept; Humans; Methotrexate | 2019 |
Causes of synthetic disease-modifying drug discontinuation in rheumatoid arthritis: Data from a large real-life cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Brazil; Cross-Sectional Studies; Female; Humans; Leflunomide; Male; Medication Adherence; Methotrexate; Middle Aged; Synthetic Drugs; Treatment Failure | 2019 |
Erosive rheumatoid arthritis in a young patient with mirror hand.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Glucocorticoids; Hand; Hand Deformities, Congenital; Humans; Hydroxychloroquine; Methotrexate; Polydactyly; Range of Motion, Articular; Treatment Outcome; Ultrasonography | 2019 |
Nanogold-core multifunctional dendrimer for pulsatile chemo-, photothermal- and photodynamic- therapy of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Biocompatible Materials; Biological Transport; Cell Survival; Combined Modality Therapy; Dendrimers; Drug Liberation; Gold; Hyperthermia, Induced; Indoles; Infrared Rays; Metal Nanoparticles; Methotrexate; Mice; Molecular Docking Simulation; Particle Size; Phototherapy; RAW 264.7 Cells; Reactive Oxygen Species; Surface Properties | 2019 |
Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis.
Topics: Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Disability Evaluation; Female; Humans; Low Back Pain; Male; Methotrexate; Middle Aged; Prevalence; Severity of Illness Index; Spinal Fractures; Spine | 2019 |
Cardiac Methotrexate-Induced Lymphoproliferative Disorder.
Topics: Aneurysm, Ruptured; Arthritis, Rheumatoid; Biopsy, Needle; Cardiac Surgical Procedures; Diagnosis, Differential; Female; Follow-Up Studies; Heart Aneurysm; Heart Neoplasms; Humans; Immunohistochemistry; Lymphoproliferative Disorders; Magnetic Resonance Imaging, Cine; Methotrexate; Middle Aged; Multimodal Imaging; Positron Emission Tomography Computed Tomography; Rare Diseases; Sinus of Valsalva; Treatment Outcome | 2019 |
A 74-year-old female with recurrent infections receiving methotrexate for rheumatoid arthritis.
Topics: Aged; Antibiotic Prophylaxis; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunocompromised Host; Immunologic Deficiency Syndromes; Methotrexate; Opportunistic Infections; Recurrence | 2019 |
Differing contribution of methotrexate polyglutamates to adalimumab blood levels as compared with etanercept.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Treatment Outcome | 2019 |
Optimal time between the last methotrexate administration and seasonal influenza vaccination in rheumatoid arthritis: post hoc analysis of a randomised clinical trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Methotrexate; Randomized Controlled Trials as Topic; Seasons; Vaccination | 2019 |
[Late-onset rheumatoid arthritis: clinical, biological, and therapeutic features About a retrospective study].
Topics: Adrenal Cortex Hormones; Age of Onset; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Comorbidity; Disease Progression; Female; Humans; Male; Methotrexate; Referral and Consultation; Retrospective Studies | 2019 |
Enhanced skin permeation of Methotrexate from penetration enhancer containing vesicles: In vitro optimization and in vivo evaluation.
Topics: Administration, Cutaneous; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Drug Carriers; Female; Liposomes; Male; Methotrexate; Particle Size; Polyethylene Glycols; Polyethyleneimine; Psoriasis; Rats; Rats, Sprague-Dawley; Rats, Wistar; Skin; Skin Absorption; Tissue Distribution | 2019 |
Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Disease Models, Animal; Freund's Adjuvant; Interleukin-17; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; NF-kappa B; Oxidative Stress; RANK Ligand; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Venlafaxine Hydrochloride | 2019 |
Occult HBV infection may negatively impact on drug survival in patients with rheumatoid arthritis on treatment with a first biologic drug. An appraisal from the Biologic Apulian Registry (BIOPURE).
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Citrullination; DNA, Viral; Etanercept; Female; Glucocorticoids; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Male; Medication Adherence; Methotrexate; Middle Aged; Registries; Retrospective Studies | 2019 |
Design and development of bioinspired calcium phosphate nanoparticles of MTX: pharmacodynamic and pharmacokinetic evaluation.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biological Availability; Calcium Phosphates; Drug Carriers; Female; Methotrexate; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2019 |
Low-dose Glucocorticoid Use Does Not Reduce Biologic Use in Early RA, Nor Do Biologics Reduce the Need for Glucocorticoids.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Glucocorticoids; Humans; Methotrexate | 2019 |
Investigating Dimensions of Stiffness in Rheumatoid and Psoriatic Arthritis: The Australian Rheumatology Association Database Registry and OMERACT Collaboration.
Topics: Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Australia; Databases, Factual; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Prednisolone; Registries; Severity of Illness Index; Treatment Outcome | 2019 |
[Why we recommend parenteral methotrexate for the treatment of rheumatoid arthritis: a response and overview of the literature].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infusions, Parenteral; Methotrexate; Treatment Outcome | 2019 |
[Further evidence necessary for initial subcutaneous administration of MTX in the treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Outcome | 2019 |
Methotrexate use, not interleukin 33, is associated with lower carotid intima-media thickness in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Female; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Male; Methotrexate; Middle Aged; Postmenopause | 2019 |
Clinical deep remission and related factors in a large cohort of patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Surveys and Questionnaires | 2019 |
Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Susceptibility; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; In Situ Hybridization; Kaplan-Meier Estimate; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2019 |
Primary malignant melanoma of the urethra in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Melanoma; Methotrexate; Urethra; Urethral Neoplasms | 2019 |
Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Incidence; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Prospective Studies; Remission Induction; Risk Factors; Severity of Illness Index | 2019 |
Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy.
Topics: Animals; Arthritis, Rheumatoid; Biomimetic Materials; Drug Delivery Systems; Humans; Joints; Macrophages; Male; Methotrexate; Mice; Nanomedicine; Nanoparticles; Osteonectin; Serum Albumin, Human; Synovial Membrane; Tissue Distribution | 2019 |
Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2019 |
Re-treatment with abatacept plus methotrexate for disease flare after complete treatment withdrawal in patients with early rheumatoid arthritis: 2-year results from the AVERT study.
Topics: Abatacept; Adult; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Prognosis; Proportional Hazards Models; Treatment Outcome | 2019 |
Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.
Topics: Adalimumab; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Cost-Benefit Analysis; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Young Adult | 2019 |
Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients.
Topics: Arthritis, Rheumatoid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Leukocytes, Mononuclear; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2019 |
Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Arthritis, Rheumatoid; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Retrospective Studies; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2019 |
Methotrexate-associated lymphoproliferative disorder in the stomach and duodenum: a case report.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Duodenal Diseases; Endoscopy, Digestive System; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Prednisone; Recurrence; Rituximab; Stomach Diseases; Vincristine; Withholding Treatment | 2019 |
Methotrexate-associated primary hepatic lymphoma and cranial neuropathy in a patient with rheumatoid arthritis: A case report with clinical follow-up over a 7-year period.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cranial Nerve Diseases; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lymphoma; Methotrexate; Recurrence | 2019 |
Membranous nephropathy caused by rheumatoid arthritis.
Topics: Anti-Citrullinated Protein Antibodies; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Glomerulonephritis, Membranous; Humans; Immunoglobulin G; Immunosuppressive Agents; Kidney; Kidney Glomerulus; Methotrexate; Middle Aged; Nephrotic Syndrome; Prednisolone; Proteinuria; Tacrolimus; Treatment Outcome | 2019 |
Methotrexate in Our Hearts.
Topics: Aged; Arthritis, Rheumatoid; Cardiovascular Diseases; Heart; Humans; Methotrexate | 2019 |
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; England; Female; Humans; Ireland; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prospective Studies; Wales | 2019 |
Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Remission Induction; Severity of Illness Index | 2019 |
Multicenter, observational clinical study of abatacept in Japanese patients with rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Aged, 80 and over; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Biomarkers; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2019 |
Transaminitis and neutropenia are rare in patients on methotrexate: evidence from a large cohort of inflammatory arthritis patients.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Methotrexate; Neutropenia; Transaminases | 2019 |
Membrane-Spanning Protein Genetic Polymorphisms Related to Methotrexate Therapeutic Outcomes in a Chinese Rheumatoid Arthritis Population.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; ATP Binding Cassette Transporter, Subfamily B; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; Middle Aged; Reduced Folate Carrier Protein | 2019 |
Treatment Strategies in Early Rheumatoid Arthritis Methotrexate Management: Results From a Prospective Cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Drug Therapy, Combination; Early Diagnosis; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prospective Studies; Time Factors; Treatment Outcome | 2020 |
A Case of Methotrexate-Associated Lymphoproliferative Disorder (Lymphomatoid Granulomatosis) of the Skin.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphomatoid Granulomatosis; Methotrexate; Skin Neoplasms | 2019 |
Methotrexate-associated Lymphoproliferative Disorders in Patients With Rheumatoid Arthritis: Clinicopathologic Features and Prognostic Factors.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Opportunistic Infections; Progression-Free Survival; Risk Assessment; Risk Factors; RNA, Viral; Time Factors | 2019 |
Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects.
Topics: Adolescent; Arthritis, Rheumatoid; Bordetella pertussis; Case-Control Studies; Citrulline; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Pertussis Vaccine; Whooping Cough | 2019 |
ADORA2A Polymorphisms Influence Methotrexate Adverse Events in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Pharmacogenomic Testing; Pharmacogenomic Variants; Pharmacovigilance; Polymorphism, Single Nucleotide; Receptor, Adenosine A2A; Receptor, Adenosine A3; Slovenia | 2019 |
Comparison of the effects of tocilizumab monotherapy and adalimumab in combination with methotrexate on bone erosion repair in rheumatoid arthritis.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Tomography, X-Ray Computed; Treatment Outcome | 2019 |
Herbo-mineral formulation 'Ashwashila' attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Drug Evaluation, Preclinical; Humans; Inflammation Mediators; Male; Medicine, Ayurvedic; Methotrexate; Mice; Minerals; Plant Extracts; Signal Transduction; THP-1 Cells | 2019 |
Cost-Effectiveness of Early Treatment with Originator Biologics or Their Biosimilars After Methotrexate Failure in Patients with Established Rheumatoid Arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; Female; Humans; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Treatment Outcome | 2019 |
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chlorhexidine; Collagen; Disease Progression; Injections, Intraperitoneal; Male; Methotrexate; Metronidazole; Mice; Mice, Inbred DBA; Periodontitis; Porphyromonas gingivalis; X-Ray Microtomography | 2019 |
Evaluation of topical human platelet lysate versus topical clobetasol in management of methotrexate-induced oral ulceration in rheumatoid arthritis patients: Randomized-controlled clinical trial.
Topics: Administration, Topical; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Platelets; Clobetasol; Glucocorticoids; Humans; Methotrexate; Middle Aged; Oral Ulcer | 2019 |
Methotrexate and doxycycline interaction: a rare cause of pancytopenia.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Doxycycline; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Pancytopenia | 2019 |
Predictors, demographics and frequency of sustained remission and low disease activity in anti-tumour necrosis factor-treated rheumatoid arthritis patients.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Body Mass Index; Drug Therapy, Combination; Etanercept; Female; Humans; Infliximab; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prognosis; Remission Induction; Severity of Illness Index; Sex Factors; Smoking; Tumor Necrosis Factor Inhibitors | 2019 |
Long-term clinical, functional, and cost outcomes for early rheumatoid arthritis patients who did or did not achieve early remission in a real-world treat-to-target strategy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biological Products; Female; Health Care Costs; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2019 |
[A Case of Small Bowel Perforation Caused by Malignant Lymphoma after Methotrexate Therapy for Rheumatoid Arthritis].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Intestinal Perforation; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Positron Emission Tomography Computed Tomography | 2019 |
Methotrexate for Prevention of Cardiovascular Events.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2019 |
Development and validation of a methotrexate adherence assay.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Male; Mass Spectrometry; Medication Adherence; Methotrexate; Middle Aged; Reproducibility of Results | 2019 |
Comment on: Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry: reply.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Registries | 2019 |
Comment on: Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Registries | 2019 |
Association between seropositivity and discontinuation of tumor necrosis factor inhibitors due to ineffectiveness in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Female; Humans; Incidence; Japan; Male; Methotrexate; Middle Aged; Prednisolone; Prognosis; Proportional Hazards Models; Registries; Remission Induction; Rheumatoid Factor; Treatment Failure; Tumor Necrosis Factor Inhibitors | 2019 |
Novel DMARD monotherapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Methotrexate | 2019 |
Initiating tocilizumab, with or without methotrexate, compared with starting methotrexate with prednisone within step-up treatment strategies in early rheumatoid arthritis: an indirect comparison of effectiveness and safety of the U-Act-Early and CAMERA-I
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cluster Analysis; Drug Therapy, Combination; Early Diagnosis; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Multilevel Analysis; Prednisone; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2019 |
Innovative HPTLC method for simultaneous determination of ternary mixture of certain DMARDs in real samples of rheumatoid arthritis patients: an application of quality by design approach.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, Thin Layer; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Sulfasalazine | 2019 |
Baseline adenosine receptor mRNA expression in blood as predictor of response to methotrexate therapy in patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Drug Resistance; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Remission Induction; RNA, Messenger; Time Factors; Treatment Outcome; Young Adult | 2019 |
Methotrexate-Associated Lymphoproliferative Disorder of the Stomach Observed by Magnifying Narrow-Band Imaging Endoscopy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Gastroscopy; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Narrow Band Imaging; Stomach Neoplasms | 2019 |
Folate Conjugated Double Liposomes Bearing Prednisolone and Methotrexate for Targeting Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Compounding; Drug Liberation; Drug Therapy, Combination; Folic Acid; Humans; Liposomes; Male; Methotrexate; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Prednisolone; Rats; Surface Properties; Tissue Distribution | 2019 |
Topics: Adalimumab; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Immunosuppressive Agents; Liver; Liver Neoplasms; Male; Methotrexate; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection | 2019 |
Shingles: More than Meets the Eye.
Topics: Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Methotrexate; Middle Aged; Pancytopenia; Stomatitis | 2019 |
Methotrexate Hepatotoxicity in Rheumatoid Arthritis: An Analysis of the Physicians' Policy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Retrospective Studies; Transaminases | 2020 |
Prevalence of methotrexate intolerance among patients with rheumatoid arthritis using the Arabic version of the methotrexate intolerance severity score.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prevalence; Reproducibility of Results; Saudi Arabia; Surveys and Questionnaires; Translating | 2019 |
The neutrophil-lymphocyte ratio in early rheumatoid arthritis and its ability to predict subsequent failure of triple therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Lymphocytes; Male; Methotrexate; Middle Aged; Neutrophils; Prognosis; Sulfasalazine; Treatment Failure | 2019 |
Leprosy after interleukin 6 inhibitor therapy in a patient with rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Dapsone; Exanthema; Female; Humans; Leprostatic Agents; Leprosy, Tuberculoid; Methotrexate; Middle Aged; Prednisone; United States | 2019 |
The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Collagen; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; Interleukin-17; Male; Malondialdehyde; Matrix Metalloproteinase 9; Methotrexate; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2019 |
Injectable Click-Crosslinked Hyaluronic Acid Depot To Prolong Therapeutic Activity in Articular Joints Affected by Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Chondrocytes; Delayed-Action Preparations; Glycosaminoglycans; Humans; Hydrogels; Injections, Intra-Articular; Interleukin-6; Joints; Male; Methotrexate; Mice; Rats; RAW 264.7 Cells; Tissue Distribution; Tumor Necrosis Factor-alpha | 2019 |
The effect of deep or sustained remission on maintenance of remission after dose reduction or withdrawal of etanercept in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanercept; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Remission Induction; Severity of Illness Index | 2019 |
Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.
Topics: Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Female; Genetic Association Studies; Humans; Liver-Specific Organic Anion Transporter 1; Logistic Models; Male; Methotrexate; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide; Treatment Outcome | 2019 |
Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate; Nasal Septal Perforation; Nasal Septum | 2019 |
Intracranial Methotrexate-Associated Lymphoproliferative Disorder in Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Female; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate; Treatment Outcome | 2019 |
The predictors of and reasons for non-adherence in an observational cohort of patients with rheumatoid arthritis commencing methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Morbidity; Prognosis; Prospective Studies; Severity of Illness Index; Treatment Outcome; United Kingdom | 2020 |
Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2019 |
Long-term safety of sarilumab in rheumatoid arthritis: an integrated analysis with up to 7 years' follow-up.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Erythema; Female; Follow-Up Studies; Humans; Incidence; Male; Methotrexate; Middle Aged; Neutropenia; Respiratory Tract Infections; Treatment Outcome | 2020 |
Calprotectin alone is not sufficient to predict response to methotrexate in early ACR/EULAR 2010 rheumatoid arthritis: Analysis of the ESPOIR cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Humans; Leukocyte L1 Antigen Complex; Methotrexate | 2020 |
Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Iatrogenic Disease; Lymphoproliferative Disorders; Methotrexate; Peptic Ulcer Perforation; Tacrolimus | 2019 |
Machine Learning to Predict Anti-Tumor Necrosis Factor Drug Responses of Rheumatoid Arthritis Patients by Integrating Clinical and Genetic Markers.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Etanercept; Female; Genetic Markers; Humans; Infliximab; Machine Learning; Male; Methotrexate; Middle Aged; Normal Distribution; Outcome Assessment, Health Care; Polymorphism, Single Nucleotide; Predictive Value of Tests; Regression Analysis; Reproducibility of Results; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2019 |
Preparation and in vitro evaluation of radiolabeled HA-PLGA nanoparticles as novel MTX delivery system for local treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Drug Evaluation, Preclinical; Hyaluronic Acid; Isotope Labeling; Lutetium; Methotrexate; Mice; Polylactic Acid-Polyglycolic Acid Copolymer; Radiopharmaceuticals; RAW 264.7 Cells | 2019 |
Serum Soluble Interleukin-2 Receptor Is a Biomarker for Pneumocystis jirovecii Pneumonia among Patients with Rheumatoid Arthritis under Methotrexate Therapy.
Topics: Aged; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Male; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumonia; Receptors, Interleukin-2; ROC Curve; Solubility; Tomography, X-Ray Computed | 2019 |
Risk of Serious Infection Among Initiators of Tumor Necrosis Factor Inhibitors Plus Methotrexate Versus Triple Therapy for Rheumatoid Arthritis: A Cohort Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor Inhibitors | 2020 |
[Wrong administration of methotrexate can lead to fatal haematological complications in elderly patients].
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Fatal Outcome; Female; Humans; Medication Errors; Methotrexate; Pancytopenia | 2013 |
Determination of methotrexate and folic acid by ion chromatography with electrochemical detection on a functionalized multi-wall carbon nanotube modified electrode.
Topics: Arthritis, Rheumatoid; Chromatography, Ion Exchange; Electrochemical Techniques; Electrodes; Folic Acid; Humans; Limit of Detection; Linear Models; Methotrexate; Nanotubes, Carbon; Reproducibility of Results | 2013 |
Pulmonary Mycobacterium abscessus disease in a patient receiving low-dose methotrexate for treatment of early rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Mycobacterium Infections, Nontuberculous | 2013 |
Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Collagen Type II; Disease Progression; Dose-Response Relationship, Drug; Edema; Inhibitory Concentration 50; Male; Methotrexate; Models, Biological; Rats; Rats, Inbred Lew; Swine; Time Factors | 2013 |
Use of biologics in a patient with rheumatoid arthritis refractory to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Infections; Methotrexate; Treatment Failure; Tuberculin Test | 2013 |
Ms Hassanzadeh, et al reply.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Care Costs; Humans; Methotrexate | 2013 |
Mature T/NK-cell lymphoproliferative disease and Epstein-Barr virus infection are more frequent in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Humans; Killer Cells, Natural; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Retrospective Studies | 2013 |
Reversible iatrogenic, MTX-associated EBV-driven lymphoproliferation with histopathological features of a lymphomatoid granulomatosis in a patient with rheumatoid arthritis.
Topics: Aged; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Cell Proliferation; Epstein-Barr Virus Infections; Humans; Iatrogenic Disease; Lymphomatoid Granulomatosis; Male; Methotrexate | 2013 |
Comment on "visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate".
Topics: Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Leishmania; Leishmaniasis, Visceral; Methotrexate | 2013 |
Primary care attitudes to methotrexate monitoring.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Drug Monitoring; General Practitioners; Guideline Adherence; Humans; Methotrexate; Practice Guidelines as Topic; Practice Patterns, Physicians'; United Kingdom | 2012 |
Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2013 |
Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the treatment of early aggressive rheumatoid arthritis trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Genetic Variation; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Randomized Controlled Trials as Topic; Regression Analysis; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Cardiovascular events are not associated with MTHFR polymorphisms, but are associated with methotrexate use and traditional risk factors in US veterans with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Registries; Risk Factors; Severity of Illness Index; Veterans | 2013 |
Effectiveness of golimumab in clinical management of patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Disease Management; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Treatment Outcome | 2013 |
Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Disease Progression; Disease-Free Survival; Female; Herpesvirus 4, Human; Humans; Immunoglobulin Heavy Chains; Immunohistochemistry; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Regression Analysis; Treatment Outcome; Virus Activation | 2013 |
[Use of NSAIDs in rheumatoid arthritis should be limited].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Review Literature as Topic | 2013 |
Oral mucositis in patients receiving low-dose methotrexate therapy for rheumatoid arthritis: report of 2 cases and literature review.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Overdose; Female; Folic Acid; Follow-Up Studies; Gingivitis, Necrotizing Ulcerative; Hospitalization; Humans; Lip Diseases; Methotrexate; Oral Ulcer; Skin Ulcer; Stomatitis; Stomatitis, Herpetic; Tongue Diseases | 2013 |
Comparison of the 1987 ACR and 2010 ACR/EULAR classification criteria for rheumatoid arthritis in clinical practice: a prospective cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Female; Foot Joints; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Prospective Studies; Radiography; Rheumatology; Sensitivity and Specificity; Symptom Assessment; Synovitis | 2013 |
Novel targeted therapies: the future of rheumatoid arthritis? Mavrilumab and tabalumab as examples.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Molecular Targeted Therapy; Rheumatology | 2013 |
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Drug Substitution; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Health Status; Humans; Hydroxychloroquine; Logistic Models; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Failure; Treatment Outcome | 2013 |
High-density lipoprotein profiling changes in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a cohort study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Lipoproteins, HDL; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Treatment of rheumatoid arthritis with methotrexate in Congolese patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Democratic Republic of the Congo; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Poverty; Prednisone; Remission Induction; Steroids; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2013 |
Treatment changes and improved outcomes in RA: an overview of a large inception cohort from 1989 to 2009.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Combined Modality Therapy; Databases, Factual; Diagnostic Imaging; Disability Evaluation; Female; Forecasting; Humans; Male; Methotrexate; Middle Aged; Needs Assessment; Netherlands; Orthopedic Procedures; Quality of Life; Retrospective Studies; Rheumatology; Severity of Illness Index; Treatment Outcome | 2013 |
Complementary and alternative medicine and conventional medicine: hand in hand.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Complementary Therapies; Ethnicity; Female; Humans; Interviews as Topic; Male; Medicine, Ayurvedic; Methotrexate; Osteoarthritis; Patient Acceptance of Health Care; Rheumatic Diseases; White People | 2013 |
Methotrexate therapy leading to a rapid progression of a previously indolent prostate cancer: is immunosuppression to blame?
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Male; Methotrexate; Prostatic Neoplasms | 2014 |
Successful desensitization to low-dose methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Desensitization, Immunologic; Drug Eruptions; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged | 2013 |
[Adalimumab for early rheumatoid arthritis - Chances and risks: Initial analyses of the OPTIMA study].
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Recovery of Function | 2013 |
Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving low-dose methotrexate treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Central Nervous System Neoplasms; Female; Humans; Immunohistochemistry; Interleukin-2 Receptor alpha Subunit; Lymphoma; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Treatment Outcome | 2013 |
Tofacitinib for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Janus Kinases; Male; Methotrexate; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2013 |
Tofacitinib for rheumatoid arthritis - Authors' reply.
Topics: Arthritis, Rheumatoid; Female; Humans; Janus Kinases; Male; Methotrexate; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2013 |
Vaccination against seasonal influenza is effective in Japanese patients with rheumatoid arthritis enrolled in a large observational cohort.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Influenza Vaccines; Influenza, Human; Japan; Male; Methotrexate; Middle Aged; Prospective Studies; Regression Analysis; Risk Factors; Seasons; Surveys and Questionnaires; Treatment Outcome | 2013 |
Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cultural Diversity; Female; Humans; Male; Methotrexate; Middle Aged; Monitoring, Physiologic; Patient Compliance; Prednisone; Prospective Studies; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Vulnerable Populations; Young Adult | 2013 |
Methotrexate-induced lymphoproliferative disease: Epstein-Barr virus-associated lymphomatoid granulomatosis.
Topics: Aged; Arthritis, Rheumatoid; Biopsy, Needle; Contrast Media; Dose-Response Relationship, Drug; Epstein-Barr Virus Infections; Female; Follow-Up Studies; Herpesvirus 4, Human; Humans; Immunohistochemistry; Lung Neoplasms; Lymphomatoid Granulomatosis; Methotrexate; Polymerase Chain Reaction; Risk Assessment; Tomography, X-Ray Computed | 2013 |
Leflunomide discontinuation in rheumatoid arthritis and influence of associated disease-modifying anti-rheumatic drugs: a survival analysis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Withholding Treatment | 2013 |
Do impaired memory, cognitive dysfunction and distress play a role in methotrexate-related neutropenia in rheumatoid arthritis patients? A comparative study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cognition Disorders; Female; Humans; Male; Memory Disorders; Methotrexate; Middle Aged; Neutropenia; Stress, Psychological | 2013 |
Reduction of plasma IL-6 but not TNF-α by methotrexate in patients with early rheumatoid arthritis: a potential biomarker for radiographic progression.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Female; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Prospective Studies; Radiography; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Making rational treatment decisions in rheumatoid arthritis when methotrexate fails.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine | 2013 |
Conventional triple therapy as good as etanercept for uncontrolled rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Failure | 2013 |
Not better but quite good: effects on work loss of combination treatment for rheumatoid arthritis with and without biological agents.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Infliximab; Male; Methotrexate; Pensions; Sick Leave; Sulfasalazine | 2013 |
Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs.
Topics: Adult; Aged; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Comorbidity; Depression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Psychiatric Status Rating Scales; Suicidal Ideation | 2013 |
Cost-minimisation analysis of subcutaneous methotrexate versus biologic therapy for the treatment of patients with rheumatoid arthritis who have had an insufficient response or intolerance to oral methotrexate.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Humans; Injections, Subcutaneous; Methotrexate; Models, Economic; Retreatment; Treatment Outcome | 2013 |
[Visceral leishmaniasis: not only a tropical disease].
Topics: Abdominal Pain; Aged; Amphotericin B; Antiprotozoal Agents; Arthritis, Rheumatoid; Female; Greece; Humans; Leishmania infantum; Leishmaniasis, Visceral; Methotrexate; Middle Aged; Netherlands; Travel; Treatment Outcome; Yugoslavia | 2013 |
Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Epstein-Barr Virus Infections; Fatal Outcome; Female; Humans; Iatrogenic Disease; Immunophenotyping; Immunosuppressive Agents; Lung Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphomatoid Granulomatosis; Lymphoproliferative Disorders; Mesenteric Ischemia; Methotrexate; Middle Aged; Pneumonia, Bacterial; Radiography; Respiratory Insufficiency | 2014 |
Expression of methotrexate transporters and metabolizing enzymes in rheumatoid synovial tissue.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Female; Ferredoxin-NADP Reductase; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Reduced Folate Carrier Protein; Synovial Membrane; Thymidylate Synthase | 2013 |
[Pharmacoeconomic evaluation for the treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Methotrexate | 2013 |
Necrotizing fasciitis in patients on methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fasciitis, Necrotizing; Female; Humans; Male; Methotrexate; Middle Aged | 2013 |
New therapies, increased risk for old infections--abdominal tuberculosis mimicking colon cancer during adalimumab treatment for rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Colonic Neoplasms; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Peritonitis, Tuberculous; Risk Factors | 2013 |
[A case of a preventable death].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Fatal Outcome; Female; Humans; Medication Errors; Methotrexate | 2013 |
Cardiovascular risk in rheumatoid arthritis: comparing TNF-α blockade with nonbiologic DMARDs.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Proportional Hazards Models; Retrospective Studies; Risk; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Enzymes; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Protein 2; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Transcriptome; Up-Regulation | 2013 |
Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Biosimilars to treat inflammatory arthritis: the challenge of proving identity.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Spondylitis, Ankylosing | 2013 |
Patient with rheumatoid arthritis on methotrexate with multiple infecting organisms causing gastritis.
Topics: Aged; Arthritis, Rheumatoid; Candidiasis; Cytomegalovirus Infections; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Immunosuppressive Agents; Male; Methotrexate | 2013 |
Cost-effectiveness of biological therapy compared with methotrexate in the treatment for rheumatoid arthritis in Colombia.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Colombia; Cost-Benefit Analysis; Female; Humans; Male; Markov Chains; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2013 |
Induced abortions in women with rheumatoid arthritis receiving methotrexate.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Methotrexate; Multivariate Analysis; Pregnancy; Young Adult | 2013 |
Safety and effectiveness of 6 months' etanercept monotherapy and combination therapy in Japanese patients with rheumatoid arthritis: effect of concomitant disease-modifying antirheumatic drugs.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Japan; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2013 |
Development of an algorithm for identifying rheumatoid arthritis in the Korean National Health Insurance claims database.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Clinical Coding; Databases, Factual; Drug Therapy, Combination; Female; Humans; Insurance Claim Reporting; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; National Health Programs; Reproducibility of Results; Republic of Korea; Young Adult | 2013 |
Improved radiological outcome of rheumatoid arthritis: the importance of early treatment with methotrexate in the era of biological drugs.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prognosis; Radiography; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2013 |
Effect of tocilizumab combined with methotrexate on circulating biomarkers of synovium, cartilage, and bone in the LITHE study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Collagen Type II; Collagen Type III; Female; Humans; Male; Methotrexate; Middle Aged; Osteocalcin | 2014 |
Factors associated with methotrexate dosing and therapeutic decisions in veterans with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Decision Making; Drug Administration Schedule; Female; Hospitals, Veterans; Humans; Male; Methotrexate; Middle Aged; Regression Analysis; Retrospective Studies; Treatment Outcome; United States; United States Department of Veterans Affairs; Veterans | 2014 |
The impact of conventional DMARD and biological therapies on CD4+ cell subsets in rheumatoid arthritis: a follow-up study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; CD4-Positive T-Lymphocytes; Etanercept; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunoglobulin G; Infliximab; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; Phenotype; Prevalence; Receptors, Tumor Necrosis Factor; Th17 Cells | 2014 |
Drug therapy. Methotrexate normalizes folate pathway genes in RA.
Topics: Arthritis, Rheumatoid; Female; Folic Acid; Humans; Male; Methotrexate; Transcriptome | 2013 |
Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis.
Topics: Adult; Aged; Antibodies; Antigens, CD1d; Arthritis, Rheumatoid; B-Lymphocytes, Regulatory; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Separation; Female; Flow Cytometry; Forkhead Transcription Factors; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; Peptides, Cyclic; Plant Extracts; Receptors, Virus | 2014 |
Five-year favorable outcome of patients with early rheumatoid arthritis in the 2000s: data from the ESPOIR cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Biological Products; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2013 |
Improving treatment with methotrexate in rheumatoid arthritis-development of a multimedia patient education program and the MiRAK, a new instrument to evaluate methotrexate-related knowledge.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Multimedia; Patient Education as Topic; Program Development; Quality of Life; Surveys and Questionnaires | 2014 |
High rate of disease remission in moderate rheumatoid arthritis on etanercept therapy: data from GISEA, the Italian biologics register.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Italy; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Registries; Remission Induction; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2014 |
Methotrexate enhances 3T3-L1 adipocytes hypertrophy.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Animals; Arthritis, Rheumatoid; Biological Transport; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Folic Acid Antagonists; Glucose; Insulin; Lipid Metabolism; Metabolic Syndrome; Methotrexate; Mice; Obesity | 2013 |
Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Oral Ulcer; Oropharynx | 2013 |
Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-α infliximab.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glycogen; Humans; Infliximab; Mass Spectrometry; Metabolome; Methotrexate; Tumor Necrosis Factor-alpha | 2013 |
[Rheumatoid arthritis: what to do if methotrexate fails?].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Treatment Failure | 2013 |
Comparative efficacy of subcutaneous versus oral methotrexate in active rheumatoid arthritis.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2013 |
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Ornithine; Pterins; Quinazolines; T-Lymphocytes; Thiophenes; Trimetrexate; Tumor Necrosis Factor-alpha | 2014 |
An immunological biomarker to predict MTX response in early RA.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Prognosis; Remission Induction; Sensitivity and Specificity; T-Lymphocyte Subsets; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
The decline in joint replacement surgery in rheumatoid arthritis is associated with a concomitant increase in the intensity of anti-rheumatic therapy: a nationwide register-based study from 1995 through 2010.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Female; Finland; Humans; Hydroxychloroquine; Male; Methotrexate; Registries; Sulfasalazine | 2013 |
Evaluation of therapeutic efficacy of Majoon Suranjan, a Unani formulation, in the treatment of rheumatoid arthritis: an experimental study.
Topics: Animals; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cattle; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Medicine, Unani; Methotrexate; Phytotherapy; Rats; Rats, Wistar; Rheumatoid Factor | 2013 |
Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Risk; Sex Factors; Treatment Outcome | 2014 |
Effect of allograft inflammatory factor-1 gene polymorphisms on rheumatoid arthritis treatment with methotrexate.
Topics: Arthritis, Rheumatoid; Calcium-Binding Proteins; DNA-Binding Proteins; Female; Genotyping Techniques; Humans; Male; Methotrexate; Microfilament Proteins; Middle Aged; Nuclear Proteins; Polymorphism, Genetic; Treatment Outcome | 2013 |
Alterations in both the activatory and inhibitory potential of peripheral blood CD4+ T cells in rheumatoid arthritis patients correlate with disease progression.
Topics: Antigens, CD; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Proliferation; CTLA-4 Antigen; Disease Progression; Female; Humans; Inflammation; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2014 |
Amgen best-seller challenged by generics.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Chloroquine; Clinical Trials as Topic; Comparative Effectiveness Research; Drug Industry; Drugs, Generic; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Therapeutic Equivalency | 2013 |
Tumor necrosis factor α inhibitor use and decreased risk for incident coronary events in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Coronary Artery Disease; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Tumor Necrosis Factor-alpha | 2014 |
[MTX associated lymphoproliferative disorder].
Topics: Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Methotrexate; Recurrence | 2013 |
Summaries for patients: tofacitinib for the treatment of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Janus Kinase 3; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Remission Induction; Treatment Outcome | 2013 |
Continuation of TNF blockade in patients with inflammatory rheumatic disease. An observational study on surgical site infections in 1,596 elective orthopedic and hand surgery procedures.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Elective Surgical Procedures; Female; Hand; Humans; Incidence; Male; Methotrexate; Middle Aged; Surgical Wound Infection; Tumor Necrosis Factor-alpha | 2013 |
RAPID3, an index of only 3 patient self-report core data set measures, but not ESR, recognizes incomplete responses to methotrexate in usual care of patients with rheumatoid arthritis.
Topics: Academic Medical Centers; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; Health Status Indicators; Humans; Longitudinal Studies; Methotrexate; Middle Aged; Pain Measurement; Predictive Value of Tests; Prospective Studies; Surveys and Questionnaires; Tennessee; Time Factors; Treatment Outcome | 2013 |
Determining best practices in early rheumatoid arthritis by comparing differences in treatment at sites in the Canadian Early Arthritis Cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Remission Induction; Severity of Illness Index; Standard of Care; Treatment Outcome | 2013 |
Clinical efficacy of abatacept compared to adalimumab and tocilizumab in rheumatoid arthritis patients with high disease activity.
Topics: Abatacept; Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prednisolone; Registries; Remission Induction; Retrospective Studies; Treatment Outcome | 2014 |
Leukoencephalopathy due to oral methotrexate.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cerebellar Diseases; Cerebellum; Diffusion Magnetic Resonance Imaging; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2) | 2014 |
Etude et suivi: rheumatoid arthritis in the 21st century.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate | 2013 |
Methotrexate-induced nausea and vomiting in adolescent and young adult patients.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Prevalence; Vomiting; Young Adult | 2014 |
A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chromones; Collagen; I-kappa B Kinase; Inflammation; Interleukin-17; Isoxazoles; Leflunomide; Male; Methotrexate; Mice; Mice, Inbred DBA; Phosphorylation; Signal Transduction; Sulfonamides; Synovial Membrane; TNF Receptor-Associated Factor 5 | 2013 |
Methotrexate-related Epstein-Barr virus-associated lymphoproliferative disorder occurring in the gingiva of a patient with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Gingiva; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate | 2013 |
[Rheumatoid arthritis: lower work loss during treatment with biologicals?--Modern treatment principles reduce work loss in rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Pensions; Sick Leave; Sulfasalazine | 2013 |
Folic acid supplementation for rheumatoid arthritis patients on methotrexate: the good gets better.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate | 2013 |
[Atypical tumor regression].
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Chemoradiotherapy, Adjuvant; Combined Modality Therapy; Esophageal Neoplasms; Esophagectomy; Esophagus; Gastrectomy; Humans; Long-Term Care; Male; Methotrexate; Microscopy, Electron; Neoplasm Regression, Spontaneous; Neoplasm, Residual | 2013 |
Methotrexate-induced accelerated nodulosis in a patient with rheumatoid arthritis and scleroderma.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Rheumatoid Nodule; Risk Factors; Scleroderma, Systemic; Time Factors | 2014 |
Biological treatment in rheumatoid arthritis: when to stop?
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate | 2014 |
Sudden glottic stenosis caused by cricoarytenoid joint involvement due to rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arytenoid Cartilage; Constriction, Pathologic; Cricoid Cartilage; Female; Glottis; Humans; Infliximab; Methotrexate; Middle Aged; Tracheostomy | 2013 |
Demyelinizing neurological disease after treatment with tumor necrosis factor alpha-inhibiting agents in a rheumatological outpatient clinic: description of six cases.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cohort Studies; Demyelinating Diseases; Etanercept; Female; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Infliximab; Male; Methotrexate; Middle Aged; Nervous System Diseases; Outpatients; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naïve early-stage rheumatoid arthritis patients.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Synovitis; Treatment Outcome; Ultrasonography | 2015 |
Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Risk Factors; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2014 |
Estimates of the prevalence of and current treatment practices for rheumatoid arthritis in Japan using reimbursement data from health insurance societies and the IORRA cohort (I).
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Female; Humans; Insurance, Health, Reimbursement; Japan; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prevalence; Severity of Illness Index | 2014 |
Periodontitis and etanercept discontinuation risk in anti-tumor necrosis factor-naive rheumatoid arthritis patients: a nationwide population-based cohort study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Periodontitis; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Assessment; Risk Factors; Sulfasalazine; Tumor Necrosis Factor-alpha | 2013 |
A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Collagen Type II; Cytokines; Drug Synergism; Drug Therapy, Combination; Female; Humans; Joints; Methotrexate; Morphinans; Osteoclasts; Osteopontin; RANK Ligand; Rats; Rats, Sprague-Dawley | 2014 |
Usability testing of ANSWER: a web-based methotrexate decision aid for patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Decision Support Techniques; Female; Humans; Internet; Male; Methotrexate; Middle Aged; Patient Education as Topic; Patient Satisfaction; User-Computer Interface | 2013 |
Methotrexate polyglutamates in erythrocytes are associated with lower disease activity in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, Liquid; Cohort Studies; Erythrocytes; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Tandem Mass Spectrometry | 2015 |
RAISE - rheumatoid arthritis independent Swiss treatment expectations and outcome: results for the abatacept subpopulation.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Switzerland; Treatment Outcome | 2013 |
Key findings towards optimising adalimumab treatment: the concentration-effect curve.
Topics: Adalimumab; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; ROC Curve; Treatment Outcome | 2015 |
Treating to the target of remission in early rheumatoid arthritis is cost-effective: results of the DREAM registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Registries; Remission Induction; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
A clinical, pathological, and genetic characterization of methotrexate-associated lymphoproliferative disorders.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; HLA Antigens; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Polymyositis; Prognosis; Retrospective Studies | 2014 |
Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Gastrointestinal Diseases; Humans; Male; Methotrexate; Middle Aged; Prevalence | 2013 |
SLC19A1 80G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Folic Acid; Gastrointestinal Tract; Genotype; Humans; Male; Methotrexate; Middle Aged; Portugal; Reduced Folate Carrier Protein; Retrospective Studies | 2014 |
The concomitant use of meloxicam and methotrexate does not clearly increase the risk of silent kidney and liver damages in patients with rheumatoid arthritis.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Asymptomatic Diseases; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Therapy, Combination; Elasticity Imaging Techniques; Female; Humans; Liver; Male; Meloxicam; Methotrexate; Middle Aged; Odds Ratio; Prospective Studies; Thiazines; Thiazoles | 2014 |
Generalization and extrapolation of treatment effects from clinical studies in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Feasibility Studies; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Models, Theoretical; Observational Studies as Topic; Pragmatic Clinical Trials as Topic; Treatment Outcome | 2014 |
Perceptions of methotrexate use in rheumatoid arthritis by rheumatologists and their patients: an Australian survey study.
Topics: Aged; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Australia; Biological Products; Drug Therapy, Combination; Female; Folic Acid; Health Care Surveys; Health Knowledge, Attitudes, Practice; Humans; Male; Methotrexate; Middle Aged; Patient Preference; Patients; Perception; Physicians; Rheumatology; Surveys and Questionnaires; Treatment Outcome | 2013 |
Rheumatoid arthritis with increased bone mineral density.
Topics: Adult; Arthritis, Rheumatoid; Bone Density; Drug Therapy, Combination; Female; Femur; Hand Bones; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lumbar Vertebrae; Methotrexate; Osteopetrosis; Radiography; Radius; Steroids; Treatment Outcome; Ulna | 2013 |
A decade of data discloses the window is still not clear.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Tumor Necrosis Factor-alpha | 2014 |
Intra articular injection with corticosteroids in patients with recent onset rheumatoid arthritis: subanalyses from the BeSt study.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Injections, Intra-Articular; Joints; Male; Methotrexate; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2014 |
CD8-positive T-cell lymphoproliferative disorder associated with Epstein-Barr virus-infected B-cells in a rheumatoid arthritis patient under methotrexate treatment.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2016 |
[A case of iatrogenic immunodeficiency-associated lymphoproliferative disease in a patient treated with methotrexate for rheumatoid arthritis for 9 consecutive years, which Showed natural remission after discontinuation of MTX therapy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunologic Deficiency Syndromes; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Time Factors | 2013 |
Comparison of the long-term outcome for patients with rheumatoid arthritis with persistent moderate disease activity or disease remission during the first year after diagnosis: data from the ESPOIR cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Cohort Studies; Disease Progression; Female; Humans; Logistic Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Peptides, Cyclic; Prognosis; Prospective Studies; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
[Case report; a case of methotrexate-associated lymphoproliferative disorders caused with multiple lung nodules].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; DNA, Viral; Female; Herpesvirus 4, Human; Humans; Lung; Lymphoproliferative Disorders; Methotrexate; Radiography, Thoracic; Tomography, X-Ray Computed | 2013 |
EBV-positive MTX-diffuse large B cell lymphoma in a rheumatoid arthritis patient.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Contrast Media; Diagnosis, Differential; Epstein-Barr Virus Infections; Female; Follow-Up Studies; Humans; In Situ Hybridization; Lymph Nodes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Positron-Emission Tomography; Radiographic Image Enhancement; Tomography, X-Ray Computed | 2014 |
Prescription patterns and trends in anti-rheumatic drug use based on a large-scale claims database in Japan.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Japan; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians' | 2015 |
Chronicity of rheumatoid arthritis affects the responsiveness of physical function, but not of disease activity measures in rheumatoid arthritis clinical trials.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Disease Progression; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Safe re-administration of tumor necrosis factor-alpha (TNFα) inhibitors in patients with rheumatoid arthritis or ankylosing spondylitis who developed active tuberculosis on previous anti-TNFα therapy.
Topics: Adalimumab; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Interferon-gamma Release Tests; Male; Methotrexate; Middle Aged; Mycobacterium tuberculosis; Receptors, Tumor Necrosis Factor; Retrospective Studies; Spondylitis, Ankylosing; Tuberculin Test; Tuberculosis; Tumor Necrosis Factor-alpha | 2014 |
Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Communication Barriers; Educational Status; Female; Health Knowledge, Attitudes, Practice; Humans; Interviews as Topic; Language; Logistic Models; Male; Methotrexate; Middle Aged; Multilingualism; Multivariate Analysis; Observational Studies as Topic | 2013 |
Unusually extensive disseminated herpes zoster with multiple ulcer formation in a methotrexate-treated rheumatoid arthritis patient.
Topics: Aged, 80 and over; Antiviral Agents; Arthritis, Rheumatoid; Fatal Outcome; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunosuppressive Agents; Methotrexate; Skin; Skin Ulcer; Viremia | 2014 |
Rituximab versus an alternative TNF inhibitor in patients with rheumatoid arthritis who failed to respond to a single previous TNF inhibitor: SWITCH-RA, a global, observational, comparative effectiveness study.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Rituximab; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemokines; Cytokines; Female; Gene Expression; Gene Expression Profiling; Humans; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Oligonucleotide Array Sequence Analysis; Receptors, Interleukin-6; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane; T-Lymphocytes | 2014 |
Subcutaneous nodules in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Rheumatoid Nodule | 2013 |
Additional barriers to clinical supervision for allied health professionals working in regional and remote settings.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Pulmonary Fibrosis | 2014 |
Safety with ocrelizumab in rheumatoid arthritis: results from the ocrelizumab phase III program.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infections; Male; Meta-Analysis as Topic; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasms; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Clinical characteristics and incidence of methotrexate-related lymphoproliferative disorders of patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Incidence; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Retrospective Studies | 2014 |
Epstein-Barr virus-related MTX-LPD in rheumatoid arthritis patients exhibits a viral pattern of the CD64 and CD35 expression on neutrophils: three case reports.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Neutrophils; Receptors, Complement 3b; Receptors, IgG | 2015 |
[The short-term efficacy and safety of methotrexate plus low dose prednisone in patients with rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2013 |
Development of myeloid sarcoma after long-term methotrexate use for rheumatoid arthritis.
Topics: Abnormal Karyotype; Aged; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Chromosome Banding; Female; Humans; Immunophenotyping; Immunosuppressive Agents; Methotrexate; Neoplasms, Second Primary; Phenotype; Positron-Emission Tomography; Sarcoma, Myeloid; Tomography, X-Ray Computed | 2014 |
Association of higher methotrexate dose with lymphoproliferative disease onset in rheumatoid arthritis patients.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Risk Factors | 2014 |
Oropharyngeal carcinoma arising after methotrexate and etanercept therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Carcinoma, Squamous Cell; Diagnosis, Differential; Etanercept; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasm Staging; Oropharyngeal Neoplasms; Receptors, Tumor Necrosis Factor | 2014 |
Presence of ultrasound subclinical synovitis and increment of serum vascular endothelial growth factor in a patient with rheumatoid arthritis achieved in sustained clinical remission by treatment with adalimumab and methotrexate.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Humans; Male; Methotrexate; Synovitis; Treatment Outcome; Ultrasonography; Vascular Endothelial Growth Factor A | 2014 |
Utilization patterns of disease-modifying antirheumatic drugs in elderly rheumatoid arthritis patients.
Topics: Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; National Health Programs; Retrospective Studies; Sex Factors | 2014 |
Treating rheumatoid arthritis to target: a Canadian patient survey.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Canada; Female; Health Surveys; Humans; Male; Methotrexate; Middle Aged; Patient Satisfaction; Practice Guidelines as Topic; Practice Patterns, Physicians'; Surveys and Questionnaires; Treatment Outcome | 2014 |
[Etanercept: does it constitute a risk factor for development of cerebral venous thrombosis?].
Topics: Adrenal Cortex Hormones; Aged; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; beta 2-Glycoprotein I; Consciousness Disorders; Drug Therapy, Combination; Emergencies; Etanercept; Female; Humans; Hydrocephalus; Immunoglobulin G; Methotrexate; Paresis; Receptors, Tumor Necrosis Factor; Sinus Thrombosis, Intracranial; Sjogren's Syndrome; Tomography, X-Ray Computed | 2014 |
Reply: To PMID 23728826.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Monitoring, Physiologic; Patient Compliance; Prednisone | 2014 |
Determining adherence to therapeutic regimens in patients with chronic illness: comment on the article by Waimann et Al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Monitoring, Physiologic; Patient Compliance; Prednisone | 2014 |
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Loci; Genetic Variation; Genome-Wide Association Study; Humans; India; Male; Methotrexate; Middle Aged; Peptide Synthases; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2014 |
Therapeutic effect of dimethyl dimethoxy biphenyl dicarboxylate on collagen-induced arthritis in rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cyclooxygenase 2; Dioxoles; Enzyme-Linked Immunosorbent Assay; Female; Interleukin-4; Interleukin-8; Methotrexate; Nitric Oxide; Platelet-Derived Growth Factor; Radiography; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2015 |
In vitro efficacy of polysaccharide-based nanoparticles containing disease-modifying antirheumatic drugs.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Chitosan; Dexamethasone; Drug Carriers; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Interleukin-8; Methotrexate; Nanoparticles; Sialic Acids; Synovial Membrane | 2014 |
Indispensable or intolerable? Methotrexate in patients with rheumatoid and psoriatic arthritis: a retrospective review of discontinuation rates from a large UK cohort.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Methotrexate; Patient Compliance; Retrospective Studies; Time Factors; Treatment Outcome; United Kingdom | 2014 |
Lymphoma of the hands in a patient with rheumatoid arthritis: case report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose Fractionation, Radiation; Female; Hand; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Positron-Emission Tomography; Radiography; Soft Tissue Neoplasms | 2014 |
Effects of adalimumab administration in bio-naïve and bio-switch rheumatoid arthritis patients in daily clinical practice : two-year results from single center.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Drug Substitution; Drug Therapy, Combination; Humans; Infliximab; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Remission Induction; Time Factors; Treatment Outcome | 2013 |
Proof-of-concept study of a Web-based methotrexate decision aid for patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Conflict, Psychological; Decision Support Techniques; Female; Health Knowledge, Attitudes, Practice; Humans; Internet; Male; Methotrexate; Middle Aged; Patient Acceptance of Health Care; Patients; Prospective Studies; Surveys and Questionnaires | 2014 |
[The effect of alcohol and fatty foods on the P-alanine aminotransferase level in rheumatoid- and psoriatic arthritis patients].
Topics: Aged; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Chemical Analysis; Diet, High-Fat; Female; Holidays; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 2013 |
Fibrosing cholestatic hepatitis after methotrexate and prednisone therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Therapy, Combination; Female; Hepatitis B; Humans; Liver Cirrhosis; Liver Failure, Acute; Liver Transplantation; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2014 |
Anti-TNF-α and risk of infections: the experience in one center.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Certolizumab Pegol; Chronic Disease; Comorbidity; Etanercept; Female; Herpes Zoster; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Infections; Infliximab; Male; Medical Records; Methotrexate; Middle Aged; Odds Ratio; Polyethylene Glycols; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha; Urinary Tract Infections | 2014 |
Glucocorticoids in the treatment of rheumatoid arthritis: still used after 65 years.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Prednisone; Treatment Outcome | 2014 |
The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Corneal Ulcer; Dry Eye Syndromes; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Models, Statistical; Severity of Illness Index; Sjogren's Syndrome; Treatment Outcome; Young Adult | 2014 |
Prevalence of metabolic syndrome in patients with rheumatoid arthritis in Morocco: a cross-sectional study of 179 cases.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Morocco; Prevalence; Risk Factors | 2014 |
Five cases of interstitial lung disease after leflunomide was combined with methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Disease Progression; Drug Interactions; Drug Therapy, Combination; Female; Finland; Humans; Incidence; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prognosis; Risk Assessment; Sampling Studies; Survival Rate | 2014 |
Different switching rate of anti-TNF-α drugs in monotherapy and in combination with methotrexate in a cohort of rheumatoid arthritis patients in the real life.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Tumor Necrosis Factor-alpha | 2014 |
Sustainability of rituximab therapy in different treatment strategies: results of a 3-year followup of a German biologics register.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Registries; Retrospective Studies; Rituximab; Treatment Outcome | 2014 |
Cost-effectiveness analysis of tocilizumab in combination with methotrexate for rheumatoid arthritis: a Markov model based on data from Serbia, country in socioeconomic transition.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Markov Chains; Methotrexate; Serbia; Socioeconomic Factors | 2014 |
Advantages of a combined rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for hand and feet: does the RAMRIS of the hand alone underestimate disease activity and progression?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Disease Progression; Foot Deformities, Acquired; Hand Deformities, Acquired; Humans; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Observer Variation; Prospective Studies; Reproducibility of Results; Severity of Illness Index; Young Adult | 2014 |
Prediction of antiarthritic drug efficacies by monitoring active matrix metalloproteinase-3 (MMP-3) levels in collagen-induced arthritic mice using the MMP-3 probe.
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Infliximab; Matrix Metalloproteinase 3; Methotrexate; Mice; Molecular Probes | 2014 |
Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and/or TNF inhibitors: a single-center retrospective
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Retrospective Studies; Treatment Outcome | 2015 |
Pulmonary and retroperitoneal lesions induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Humans; Lung; Lymphoproliferative Disorders; Male; Methotrexate; Retroperitoneal Fibrosis; Tomography, X-Ray Computed | 2016 |
Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Cohort Studies; Colorectal Neoplasms; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Receptors, Tumor Necrosis Factor; Registries; Risk Factors; Smoking; Tumor Necrosis Factor-alpha; United Kingdom | 2015 |
Multicentric reticulohistiocytosis can mimic rheumatoid arthritis.
Topics: Alendronate; Arthritis, Rheumatoid; Biopsy, Needle; Diagnosis, Differential; Drug Therapy, Combination; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Hydroxychloroquine; Immunohistochemistry; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2014 |
Necrobiosis lipoidica occurring in a patient with rheumatoid arthritis on concurrent tumor necrosis factor-α inhibitor therapy.
Topics: Adalimumab; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Leg Dermatoses; Methotrexate; Necrobiosis Lipoidica; Prednisone; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Moving the injectable methotrexate service closer to home: a practice development initiative.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Patient Selection; Practice Patterns, Nurses'; Self Administration; United Kingdom | 2014 |
Epstein-Barr virus-associated methotrexate-induced accelerated rheumatoid nodulosis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunohistochemistry; Lymph Nodes; Methotrexate; Rheumatoid Nodule; RNA, Viral; Tomography, X-Ray Computed; Treatment Outcome | 2015 |
Effects of a biologic agent in a patient with rheumatoid arthritis after treatment for methotrexate-associated B-cell lymphoma: a case report.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Etanercept; Humans; Immunoglobulin G; Immunologic Factors; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Rituximab | 2014 |
Translation and validation of the Turkish language version of the Rheumatoid Arthritis Disease Activity Index-5.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Feasibility Studies; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Quality of Life; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires; Translating; Treatment Outcome; Turkey | 2017 |
The impact of hepatitis screening on diagnosis and treatment in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis C Antibodies; Humans; Immunosuppressive Agents; Inflammation; Male; Mass Screening; Methotrexate; Middle Aged; Prevalence; Young Adult | 2014 |
Metastatic bone lesion due to methotrexate and etanercept 24 years after breast cancer treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Etanercept; Female; Humans; Immunoglobulin G; Lumbar Vertebrae; Methotrexate; Neoplasms, Second Primary; Receptors, Tumor Necrosis Factor; Spinal Neoplasms; Time Factors | 2014 |
Multidrug resistance protein-1 expression, function and polymorphisms in patients with rheumatoid arthritis not responding to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Genotyping Techniques; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Treatment Failure | 2014 |
Are glucocorticoids harmful to bone in early rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Glucocorticoids; Humans; Methotrexate; Osteoporosis; Prednisone | 2014 |
Correlation between receptor activator of nuclear factor-κβ ligand (RANKL), and osteoprotegerin (OPG) with cartilage degradation in rheumatoid arthritis patients.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cartilage; Cartilage Oligomeric Matrix Protein; Cross-Sectional Studies; Female; Humans; Methotrexate; Middle Aged; Osteoprotegerin; RANK Ligand; Young Adult | 2014 |
The issue of bioavailability of oral low dose methotrexate: should we choose only 10 mg of MTX a week in conjunction with anti-TNF therapy?
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2014 |
The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Interleukin-10; Male; Methotrexate; Methylprednisolone; Middle Aged; T-Lymphocytes, Regulatory; Th17 Cells | 2015 |
Coxiella burnetii infection (Q fever) in rheumatoid arthritis patients with and without anti-TNFα therapy.
Topics: Adalimumab; Adrenal Cortex Hormones; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Epidemics; Etanercept; Female; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Netherlands; Opportunistic Infections; Q Fever; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase | 2014 |
Methotrexate-associated lymphoproliferative disorder arising in the retromolar triangle and lung of a patient with rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Epstein-Barr Virus Infections; Female; Humans; In Situ Hybridization; Lymphoproliferative Disorders; Methotrexate; Prednisone; Rituximab; Vincristine | 2014 |
Early, structured disease modifying anti-rheumatic drug (DMARD) therapy reduces cardiovascular risk in rheumatoid arthritis--a single centre study using non-biologic drugs.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cholesterol; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Middle Aged; Severity of Illness Index; Sulfasalazine; Triglycerides; Young Adult | 2013 |
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Obesity; Overweight; Pain; Pain Measurement; Prognosis; Registries; Remission Induction; Severity of Illness Index; Sweden; Treatment Outcome | 2014 |
Assessment of income growth in patients with rheumatoid arthritis treated with anti-tumor necrosis factor therapy.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Income; Infliximab; Insurance Claim Review; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Receptors, Tumor Necrosis Factor | 2015 |
Tocilizumab in the treatment of rheumatoid arthritis: a cost-effectiveness analysis in the UK.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Contraindications; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Humans; Interleukin-6; Methotrexate; Models, Economic; Quality of Life; Surveys and Questionnaires; Treatment Outcome; United Kingdom | 2014 |
Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund׳s adjuvant induced arthritis in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Dose-Response Relationship, Drug; Freund's Adjuvant; Fruit; Interleukin-10; Male; Medicine, Chinese Traditional; Methotrexate; Plant Extracts; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Xanthium | 2014 |
High serum level of haptoglobin is associated with the response of 12 weeks methotrexate therapy in recent-onset rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Drug Resistance; Female; Haptoglobins; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; RNA, Messenger; Time Factors; Treatment Outcome; Up-Regulation | 2016 |
Deterioration of the immune response induced by sulfamethoxazole-trimethoprim in a rheumatoid arthritis patient with Pneumocystis jirovecii pneumonia.
Topics: Aged; Anti-Infective Agents; Arthritis, Rheumatoid; Chemotherapy, Adjuvant; Female; Glucocorticoids; Humans; Lung; Methotrexate; Methylprednisolone; Pneumocystis carinii; Pneumonia, Pneumocystis; Polymerase Chain Reaction; Prednisolone; Radiography; Trimethoprim, Sulfamethoxazole Drug Combination | 2014 |
Rheumatoid arthritis/methotrexate-associated primary cutaneous diffuse large B-cell lymphoma, leg type.
Topics: Aged; Arthritis, Rheumatoid; B-Lymphocytes; Humans; Leg; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Skin Neoplasms; Translocation, Genetic | 2014 |
Ten-year followup of infliximab therapy in rheumatoid arthritis patients with severe, longstanding refractory disease: a cohort study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Pain Measurement; Retreatment; Treatment Outcome | 2014 |
Clinical manifestation and prognostic factors of 32 Japanese patients with autoimmune disease-associated diffuse large B-cell lymphoma.
Topics: Aged; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Autoimmune Diseases; Disease-Free Survival; Female; Humans; Japan; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Retrospective Studies; Treatment Outcome | 2015 |
Comments on the paper showing an exceptionally favorable response to tofacitinib among Japanese rheumatoid patients and an issue surrounding clinical trial led by pharmaceutical company.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Pyrimidines; Pyrroles | 2015 |
Rituximab impairs immunoglobulin (Ig)M and IgG (subclass) responses after influenza vaccination in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal, Murine-Derived; Antibodies, Viral; Arthritis, Rheumatoid; Female; Hemagglutination Inhibition Tests; Humans; Immunoglobulin G; Immunoglobulin M; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Rituximab; Vaccination | 2014 |
A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Drug Combinations; Drug Delivery Systems; Hyaluronic Acid; Methotrexate; Mice | 2014 |
Is there a direct relationship between serum level of methotrexate and clinical efficacy and tolerability?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate | 2014 |
Retrospective evaluation of continuation rates following a switch to subcutaneous methotrexate in rheumatoid arthritis patients failing to respond to or tolerate oral methotrexate: the MENTOR study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Child, Preschool; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Retrospective Studies | 2014 |
Methotrexate and lung disease in rheumatoid arthritis: comment on the article by Conway et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate | 2014 |
Reply: To PMID 24757133.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate | 2014 |
Response to H Zeidler's comments on the CONCERTO study.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2014 |
N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Freund's Adjuvant; Inflammation; Male; Methotrexate; NF-kappa B; Rats; Rats, Inbred Lew; Serotonin | 2014 |
Clinical and serological predictors of remission in rheumatoid arthritis are dependent on treatment regimen.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisolone; Remission Induction; Rheumatoid Factor; Sex Factors; Treatment Outcome | 2014 |
Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Tripterygium | 2014 |
Concurrent use of methotrexate and celecoxib increases risk of silent liver fibrosis in rheumatoid arthritis patients with subclinical reduced kidney function.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cross-Sectional Studies; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Incidence; Kidney; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Multivariate Analysis; Pilot Projects; Pyrazoles; Risk Factors; Sulfonamides; Time Factors; Treatment Outcome | 2014 |
Use of oral and subcutaneous methotrexate in rheumatoid arthritis patients in the United States.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Medicare; Methotrexate; Middle Aged; Multivariate Analysis; Retrospective Studies; Treatment Outcome; United States | 2014 |
Tuberculosis of the tongue in a patient with rheumatoid arthritis treated with methotrexate and adalimumab.
Topics: Adalimumab; Aged; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Methotrexate; Rituximab; Tongue Diseases; Treatment Outcome; Tuberculosis, Oral | 2014 |
Response to: 'is there a direct relationship between serum level of methotrexate and clinical efficacy and tolerability?' by Fleishman and Yazici.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate | 2014 |
A twisted tale of PRES.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Posterior Leukoencephalopathy Syndrome; Tomography, Emission-Computed, Single-Photon | 2015 |
Methotrexate-associated nonalcoholic fatty liver disease with transaminitis in rheumatoid arthritis.
Topics: Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Humans; Male; Methotrexate; Middle Aged; Non-alcoholic Fatty Liver Disease; Risk Factors; Singapore | 2014 |
Complete heart block in a case of rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Heart Block; Humans; Hydroxychloroquine; Methotrexate; Pacemaker, Artificial | 2013 |
Inhibition of radiographic joint damage in rheumatoid arthritis patients in DAS28 remission using single- or combined with methotrexate non biological disease-modifying antirheumatic drug therapy in routine clinical practice.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Foot Joints; Hand Joints; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies; Tacrolimus; Treatment Outcome | 2015 |
Left ventricular regional dysfunction using cardiac magnetic resonance imaging in rheumatoid arthritis patients without cardiac symptoms: comparison between methotrexate and biologics treatment groups.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Ventricular Dysfunction, Left | 2014 |
Rheumatoid arthritis: can tofacitinib be used as first-line monotherapy for RA?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Five-year outcome in immune-mediated scleritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Female; Follow-Up Studies; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Polychondritis, Relapsing; Prednisone; Retrospective Studies; Scleritis; Treatment Outcome | 2014 |
Comment on: 'comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial' by Qian-wen et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Research Design; Tripterygium | 2014 |
[Cardiovascular diseases in patients with rheumatoid arthritis during long-term methotrexate therapy].
Topics: Adult; Age Factors; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Carotid Intima-Media Thickness; Dose-Response Relationship, Drug; Female; Humans; Incidence; Lipoproteins, HDL; Male; Methotrexate; Middle Aged; Patient Acuity; Prevalence; Rheumatoid Factor; Risk Factors; Russia; Sex Factors; Time | 2014 |
Antiphospholipid antibodies during 6-month treatment with infliximab: a preliminary report.
Topics: Adult; Antibodies, Antiphospholipid; Antibodies, Monoclonal; Arthritis, Rheumatoid; beta 2-Glycoprotein I; Cardiolipins; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Statistics, Nonparametric; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
Longterm retention rate and risk factor for discontinuation due to insufficient efficacy and adverse events in Japanese patients with rheumatoid arthritis receiving etanercept therapy.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Japan; Kaplan-Meier Estimate; Longitudinal Studies; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Factors; Treatment Failure; Treatment Outcome; Withholding Treatment | 2014 |
Paying attention to the preciseness of conclusion.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Research Design; Tripterygium | 2014 |
Latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Endpoint Determination; Humans; Injections, Subcutaneous; Methotrexate; Models, Statistical; Multicenter Studies as Topic; Psoriasis; Randomized Controlled Trials as Topic; Reproducibility of Results; Ustekinumab | 2014 |
The use of sirolimus to treat Kaposi's sarcoma in an HIV-negative rheumatoid arthritis patient on disease-modifying drug therapies.
Topics: Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis, Rheumatoid; HIV Seronegativity; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisone; Sarcoma, Kaposi; Sirolimus; Skin Neoplasms | 2015 |
Cutaneous erosions: a herald for impending pancytopenia in methotrexate toxicity.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Skin; Skin Ulcer | 2014 |
The TRIFRA trial: efforts employed to minimise expectation bias.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Phytotherapy; Plant Extracts; Randomized Controlled Trials as Topic; Research Design; Tripterygium | 2014 |
Clinical and radiological dissociation of anti-TNF plus methotrexate treatment in early rheumatoid arthritis in routine care: results from the ABRAB study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Female; Humans; Hungary; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
TwHF versus methotrexate in the treatment of rheumatoid arthritis: response to Landewe's comment on the TRIFRA study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Phytotherapy; Tripterygium | 2014 |
Efficacy of the clinical use of iguratimod therapy in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Female; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2015 |
Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Female; Genotype; HLA-C Antigens; Humans; Male; Methotrexate; Middle Aged; Pharmacogenetics; Phenotype; Receptors, KIR; Treatment Outcome; Young Adult | 2014 |
Association of MDR1 C3435T and RFC1 G80A polymorphisms with methotrexate toxicity and response in Jordanian rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arabs; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Female; Gene Frequency; Humans; Jordan; Male; Methotrexate; Middle Aged; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2014 |
Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; DNA-Activated Protein Kinase; Dose-Response Relationship, Drug; eIF-2 Kinase; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes; NF-kappa B; Nuclear Proteins; RNA, Long Noncoding; T-Lymphocytes; Tumor Suppressor Protein p53 | 2014 |
Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: results from the GISEA register.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Rituximab; Treatment Outcome | 2014 |
Purulent pericarditis in rheumatoid arthritis treated with rituximab and methotrexate.
Topics: Aged; Anti-Bacterial Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiac Tamponade; Electrocardiography; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Pericardial Effusion; Pericarditis; Rituximab; Staphylococcal Infections; Treatment Outcome | 2014 |
Polymorphisms in genes involved in the mechanism of action of methotrexate: are they associated with outcome in rheumatoid arthritis patients?
Topics: Adult; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Genetic Association Studies; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase; Treatment Outcome | 2014 |
Response to D.M. Marcus's comment on the TRIFRA study (comparison of Tripterygium wilfordii Hook F vs methotrexate in the treatment of active rheumatoid arthritis).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Phytotherapy; Tripterygium | 2014 |
Therapy: oral or subcutaneous methotrexate for rheumatoid arthritis?
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate | 2014 |
Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: an observational cohort study.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Cohort Studies; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2015 |
Methotrexate-mediated inhibition of nuclear factor κB activation by distinct pathways in T cells and fibroblast-like synoviocytes.
Topics: Adult; Aged; Apoptosis; Arthritis, Rheumatoid; Biopterins; Case-Control Studies; Cell Line; Female; Fibroblasts; Humans; Jurkat Cells; Male; MAP Kinase Kinase 4; Methotrexate; Middle Aged; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Synovial Membrane | 2015 |
SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gastrointestinal Tract; Haplotypes; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Middle Aged; Organic Anion Transporters; Polymorphism, Single Nucleotide; Portugal; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Retrospective Studies | 2014 |
Treating to target with etanercept in rheumatoid arthritis: cost-effectiveness of dose reductions when remission is achieved.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Etanercept; Humans; Immunoglobulin G; Markov Chains; Methotrexate; Models, Economic; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Registries; Remission Induction; Sweden; Treatment Outcome | 2014 |
Bisphosphonate-associated osteonecrosis of jaw reoccurrence after methotrexate therapy: a case report.
Topics: Aged; Alendronate; Amoxicillin; Anti-Bacterial Agents; Apicoectomy; Arthritis, Rheumatoid; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Drug Interactions; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Methotrexate; Osteoporosis; Tooth Extraction; Wound Healing | 2014 |
Combined effects of infliximab and methotrexate on rheumatoid arthritis osteoblastic cell metabolism.
Topics: Adult; Alkaline Phosphatase; Arthritis, Rheumatoid; Cell Proliferation; Female; Humans; Immunologic Factors; Infliximab; Interleukin-6; Male; Methotrexate; Middle Aged; Osteoblasts; Osteocalcin | 2015 |
A painful inflammatory lesion on the dorsum of the hand of a patient with rheumatoid arthritis treated with methotrexate.
Topics: Acrodermatitis; Arthritis, Rheumatoid; Borrelia burgdorferi; Hand; Hand Dermatoses; Humans; Immunosuppressive Agents; Lyme Disease; Methotrexate; Pain Management | 2014 |
Disease characteristics and treatment patterns in veterans with rheumatoid arthritis and concomitant hepatitis C infection.
Topics: Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Comorbidity; Female; Hepatitis C; Humans; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Registries; Treatment Outcome; Tumor Necrosis Factor-alpha; Veterans | 2015 |
Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Substitution; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Determinants of erythrocyte methotrexate polyglutamate levels in rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Follow-Up Studies; Humans; Linear Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Netherlands; Polyglutamic Acid; Prospective Studies; Reproducibility of Results; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Time Factors; Treatment Outcome | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Tofacitinib versus methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles | 2014 |
Increased plasma IL-17F levels in rheumatoid arthritis patients are responsive to methotrexate, anti-TNF, and T cell costimulatory modulation.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cohort Studies; Cross-Sectional Studies; Female; Humans; Interleukin-17; Male; Methotrexate; Middle Aged; T-Lymphocytes; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Modifications in lipid levels are independent of serum TNF-α in rheumatoid arthritis: results of an observational 24-week cohort study comparing patients receiving etanercept plus methotrexate or methotrexate as monotherapy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Lipids; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2014 |
Profound reduction in hospital admissions and musculoskeletal surgical procedures for rheumatoid arthritis with concurrent changes in clinical practice (1995-2010).
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Female; Hospitalization; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Orthopedic Procedures; Outcome Assessment, Health Care; Retrospective Studies; Rheumatology; Tumor Necrosis Factor-alpha | 2015 |
Biologic-free remission of established rheumatoid arthritis after discontinuation of abatacept: a prospective, multicentre, observational study in Japan.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunoconjugates; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Treatment Outcome; Withholding Treatment | 2015 |
Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, CD; Antigens, Surface; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cell Differentiation; Cell Movement; Chemotaxis; Humans; Immunohistochemistry; Infliximab; Male; Methotrexate; Middle Aged; Orexin Receptors; Osteoclasts; Receptors, Cell Surface; Signal Transduction; Th17 Cells | 2015 |
The risk of cancer in patients with rheumatoid arthritis taking tumor necrosis factor antagonists: a nationwide cohort study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cohort Studies; Cyclosporine; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Incidence; Insurance; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasms; Outcome Assessment, Health Care; Proportional Hazards Models; Receptors, Tumor Necrosis Factor; Risk Factors; Taiwan; Tumor Necrosis Factor-alpha | 2014 |
Late-onset methotrexate-induced pneumonitis with neutrophilia in bronchoalveolar lavage fluid.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Female; Humans; Methotrexate; Middle Aged; Neutrophils; Pneumonia | 2014 |
Role of key TYMS polymorphisms on methotrexate therapeutic outcome in portuguese rheumatoid arthritis patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Methotrexate; Middle Aged; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Portugal; Retrospective Studies; Thymidylate Synthase; Treatment Outcome | 2014 |
Clinical endpoint sensitivity in rheumatoid arthritis: modeling and simulation.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Computer Simulation; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Models, Biological; Severity of Illness Index; Treatment Outcome | 2014 |
Methotrexate-related lymphoproliferative disorder arising in the gingiva of a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Gingival Neoplasms; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Oral Ulcer; Osteonecrosis | 2015 |
Treatment of rheumatoid arthritis with methotrexate alone and in combination with other conventional DMARDs using the T2T strategy. A cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cohort Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Sulfasalazine; Treatment Outcome; Young Adult | 2015 |
Therapy-related myeloid neoplasm in methotrexate-associated lymphoproliferative disease in a rheumatoid arthritis patient.
Topics: Arthritis, Rheumatoid; Bone Marrow; Fatal Outcome; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; In Situ Hybridization, Fluorescence; Leukemia, Myeloid; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Neoplasms, Second Primary | 2014 |
Automatic identification of methotrexate-induced liver toxicity in patients with rheumatoid arthritis from the electronic medical record.
Topics: Algorithms; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Electronic Health Records; Humans; Immunosuppressive Agents; Liver; Methotrexate | 2015 |
Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Female; Immunosuppressive Agents; Male; Methotrexate; Mice; Sesquiterpenes, Guaiane | 2015 |
Soluble OX40L is associated with presence of autoantibodies in early rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Monocytes; OX40 Ligand; Peptides, Cyclic; Receptors, OX40; Solubility; Synovial Fluid; T-Lymphocytes; Time Factors; Treatment Outcome | 2014 |
Still trying to understand methotrexate.
Topics: Arthritis, Rheumatoid; Erythrocytes; Female; Humans; Male; Methotrexate; Polyglutamic Acid | 2014 |
Methotrexate use in a breastfeeding patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Breast Feeding; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant Health; Infant, Newborn; Methotrexate; Milk, Human; Patient Safety; Postpartum Period; Pregnancy; Pregnancy, High-Risk; Risk Assessment | 2014 |
Impact of biologic agents with and without concomitant methotrexate and at reduced doses in older rheumatoid arthritis patients.
Topics: Adalimumab; Age Factors; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Injections; Kaplan-Meier Estimate; Male; Medicare; Methotrexate; Proportional Hazards Models; Receptors, Tumor Necrosis Factor; Retrospective Studies; Self Administration; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United States | 2015 |
Rheumatoid arthritis: Methotrexate and bridging glucocorticoids in early RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Isoxazoles; Male; Methotrexate; Prednisone; Sulfasalazine | 2014 |
A population model of early rheumatoid arthritis disease activity during treatment with methotrexate, sulfasalazine and hydroxychloroquine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Data Interpretation, Statistical; Disease Progression; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Joints; Male; Methotrexate; Middle Aged; Models, Biological; Predictive Value of Tests; Severity of Illness Index; Sulfasalazine; Time Factors; Treatment Outcome; Young Adult | 2015 |
Factors influencing ultrasonographic remission in patients with rheumatoid arthritis.
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Delayed Diagnosis; Etanercept; Female; Hand Joints; Humans; Isoxazoles; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Remission Induction; Rituximab; Severity of Illness Index; Sulfasalazine; Synovitis; Tenosynovitis; Time Factors; Ultrasonography, Doppler | 2015 |
Hepatosplenic Hodgkin lymphoma without lymphadenopathy following reversible methotrexate-associated lymphoproliferative disorder.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Female; Hodgkin Disease; Humans; Immunosuppressive Agents; Infliximab; Liver; Lymphadenopathy; Methotrexate; Spleen | 2017 |
Methotrexate treatment in myasthenia gravis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Myasthenia Gravis | 2014 |
Clinicopathological characteristics and rituximab addition to cytotoxic therapies in patients with rheumatoid arthritis and methotrexate-associated large B lymphoproliferative disorders.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; In Situ Hybridization; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-2; Rituximab; RNA, Viral | 2015 |
Patients with rheumatoid arthritis have better functional and working ability but poorer general health and higher comorbidity rates today than in the late 1990s.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Employment; Female; Finland; Health Status; Humans; Hydroxychloroquine; Hyperlipidemias; Hypertension; Male; Methotrexate; Middle Aged; Neoplasms; Patient Outcome Assessment; Respiratory Tract Diseases; Sulfasalazine; Tumor Necrosis Factor-alpha | 2015 |
A new meaning to butterflies in the stomach.
Topics: Abdominal Pain; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Endoscopy, Gastrointestinal; Female; Humans; Intestinal Obstruction; Methotrexate; Nausea; Peritoneal Fibrosis; Predictive Value of Tests; Tomography, X-Ray Computed; Vomiting | 2015 |
Discontinuation of tumour necrosis factor inhibitors in patients with rheumatoid arthritis in low-disease activity: persistent benefits. Data from the Corrona registry.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Registries; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Effectiveness of TNF inhibitor treatment with various methotrexate doses in patients with rheumatoid arthritis: results from clinical practice.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Methotrexate; Middle Aged; Registries; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Methylene tetrahydrofolate reductase genotypes frequencies: association with toxicity and response to methotrexate in rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Gene Frequency; Genotype; Haplotypes; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide | 2015 |
I've been taking methotrexate for my rheumatoid arthritis (RA) for several years, but it doesn't seem to be helping my symptoms. My doctor suggested adding a biologic response modifier (BRM) drug, such as etanercept (Enbrel) or adalimumab (Humira) to my t
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Neoplasms; Receptors, Tumor Necrosis Factor | 2014 |
Safety of disease-modifying antirheumatic drugs and biologic agents for rheumatoid arthritis patients in real-life conditions.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2015 |
Risk of venous thromboembolism in patients with rheumatoid arthritis: initiating disease-modifying antirheumatic drugs.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Humans; Incidence; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Risk Factors; Venous Thromboembolism | 2015 |
Analysis of clinical factors related to the efficacy of shoulder arthroscopic synovectomy plus capsular release in patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; C-Reactive Protein; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Joint Capsule Release; Male; Methotrexate; Middle Aged; Prednisolone; Range of Motion, Articular; Shoulder Joint; Synovectomy; Treatment Outcome | 2015 |
Spinal epidural abscess following minimally invasive dental examination in a rheumatoid arthritis patient receiving methotrexate, glucocorticoids, and anti-tumor necrosis factor therapy.
Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Biological Products; Dental Care; Drug Therapy, Combination; Epidural Abscess; Glucocorticoids; Humans; Laminectomy; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Risk Factors; Spine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
A case of rheumatoid arthritis with Felty syndrome complicated by late-onset ankylosing spondylitis and psoriatic arthritis: a potpourri of rheumatic diseases.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Felty Syndrome; Humans; Male; Methotrexate; Spondylitis, Ankylosing; Treatment Outcome | 2015 |
[Comorbidity in rheumatic diseases. Check the heart and kidneys of your arthritis patient!].
Topics: Albuminuria; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Comorbidity; Drug Substitution; Glucocorticoids; Humans; Long-Term Care; Methotrexate; Tumor Necrosis Factor-alpha | 2014 |
Identification of S100A9 as biomarker of responsiveness to the methotrexate/etanercept combination in rheumatoid arthritis using a proteomic approach.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Calgranulin A; Calgranulin B; Cohort Studies; Drug Combinations; Etanercept; Female; Humans; Immunoglobulin G; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Proteomics; Receptors, Tumor Necrosis Factor; Young Adult | 2014 |
Cost-effectiveness of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, versus methotrexate in patients with rheumatoid arthritis using real-world data from the IORRA observational cohort study.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Health Care Costs; Humans; Japan; Male; Methotrexate; Middle Aged; Quality of Life; Quality-Adjusted Life Years; Receptors, Interleukin-6; Treatment Outcome | 2015 |
Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Hindlimb; Isoxazoles; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Rats; Rats, Wistar; Spleen | 2015 |
Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Disease Progression; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proportional Hazards Models; Remission Induction; Sulfasalazine; Time-to-Treatment; Treatment Outcome | 2015 |
Cost-effectiveness of TNF inhibitors vs synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a Markov model study based on two longitudinal observational studies.
Topics: Adalimumab; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Etanercept; Female; Health Status; Humans; Immunoglobulin G; Infliximab; Longitudinal Studies; Male; Markov Chains; Methotrexate; Middle Aged; Models, Statistical; Norway; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Evaluation of drug-drug interaction between the novel cPLA2 inhibitor AK106-001616 and methotrexate in rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Demography; Drug Interactions; Enzyme Inhibitors; Female; Group IV Phospholipases A2; Humans; Kinetics; Male; Methotrexate; Middle Aged; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent | 2015 |
Sugarcane bagasse lignin, and silica gel and magneto-silica as drug vehicles for development of innocuous methotrexate drug against rheumatoid arthritis disease in albino rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulose; Disease Models, Animal; Drug Carriers; Knee Joint; Magnetic Fields; Male; Methotrexate; Rats; Saccharum; Silica Gel | 2015 |
Methotrexate therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate | 2015 |
Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclin D1; Female; Gene Frequency; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Thymidylate Synthase | 2015 |
Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cell Proliferation; CTLA-4 Antigen; DNA Methylation; Enhancer Elements, Genetic; Enzyme-Linked Immunosorbent Assay; Female; Forkhead Transcription Factors; Humans; Interferon-gamma; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Real-Time Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes, Regulatory | 2015 |
Newly identified antiatherosclerotic activity of methotrexate and adalimumab: complementary effects on lipoprotein function and macrophage cholesterol metabolism.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cholesterol; Female; Humans; In Vitro Techniques; Lipoproteins, HDL; Lipoproteins, LDL; Macrophages; Male; Methotrexate; Middle Aged; Scavenger Receptors, Class B | 2015 |
[Cutaneous and haematological adverse events after methotrexate therapy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Ecchymosis; Female; Humans; Leg Ulcer; Methotrexate; Middle Aged; Purpura | 2015 |
Quality process measures for rheumatoid arthritis: performance from members enrolled in a national health plan.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Female; Humans; Male; Methotrexate; Middle Aged; Process Assessment, Health Care; Quality of Health Care | 2015 |
The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Czech Republic; Female; Heterozygote; Homozygote; Humans; Linear Models; Logistic Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Pharmacogenetics; Phenotype; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prospective Studies; Retrospective Studies; Risk Factors; Treatment Outcome | 2015 |
Nodules in patients with rheumatoid arthritis and methotrexate treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule | 2015 |
Chronological changes in baseline disease activity of patients with rheumatoid arthritis who received biologic DMARDs between 2003 and 2012.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2015 |
Etanercept tapering in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor | 2015 |
Etanercept tapering in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor | 2015 |
High variability in glucocorticoid starting doses in patients with rheumatoid arthritis: observational data from an early arthritis cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Outpatient Clinics, Hospital; Practice Patterns, Physicians'; Prednisolone; Private Practice; Professional Practice Location; Prospective Studies; Rheumatology; Severity of Illness Index; Treatment Outcome | 2015 |
Response to Dr Minota's Letter to the Editor of Modern Rheumatology Regarding a Study of Tofacitinib in Japanese Patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunomodulation; Male; Methotrexate; Pyrimidines; Pyrroles | 2016 |
A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence.
Topics: Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Drug Monitoring; Folic Acid Antagonists; Humans; Limit of Detection; Mass Spectrometry; Methotrexate | 2015 |
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis.
Topics: 5'-Nucleotidase; Adenosine; Animals; Antigens, CD; Apyrase; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Drug Resistance; Humans; Lymphocyte Count; Methotrexate; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2015 |
Determinants of reaching drug-free remission in patients with early rheumatoid or undifferentiated arthritis after one year of remission-steered treatment.
Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Logistic Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prednisone; Remission Induction; Remission, Spontaneous; Treatment Outcome | 2015 |
No association between TNF inhibitor and methotrexate therapy versus methotrexate in changes in hemoglobin A1C and fasting glucose among psoriasis, psoriatic arthritis, and rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Female; Glycated Hemoglobin; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Tumor Necrosis Factor-alpha | 2015 |
Long-term safety and efficacy of treatment with subcutaneous abatacept in Japanese patients with rheumatoid arthritis who are methotrexate inadequate responders.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Retreatment; Treatment Outcome | 2015 |
Treat-to-target approach in daily clinical practice in Pakistani patients with early Rheumatoid Arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Lost to Follow-Up; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2015 |
Lymphoma Risk in Japanese Patients With Rheumatoid Arthritis: Comment on the Article by Kameda et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Male; Methotrexate | 2015 |
Drugs and cardiovascular risk in inflammatory arthritis: another case of glucocorticoid-bashing?
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2015 |
Methotrexate-associated lymphoproliferative disorders: management by watchful waiting and observation of early lymphocyte recovery after methotrexate withdrawal.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Disease Management; Female; Follow-Up Studies; Humans; Immunoglobulin G; Lymphocyte Count; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Neoplasm Regression, Spontaneous; Prognosis; Retrospective Studies; Watchful Waiting | 2015 |
Serum KL-6 elevation and possible pulmonary involvement in patients with rheumatoid arthritis treated with biological agents.
Topics: Arthritis, Rheumatoid; Biological Factors; Demography; Disease Progression; Fibrosis; Humans; Lung; Methotrexate; Middle Aged; Mucin-1; Radiography, Thoracic; Time Factors; Tomography, X-Ray Computed | 2014 |
[A case of methotrexate-associated lymphoproliferative disorder diagnosed by liver biopsy].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Fatal Outcome; Female; Humans; Liver; Lymphoproliferative Disorders; Methotrexate | 2015 |
Five-year administration of tocilizumab to a patient with rheumatoid arthritis complicated by severe chronic heart failure.
Topics: Adult; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Chronic Disease; Diagnostic Imaging; Drug Therapy, Combination; Heart Failure; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Association between tumor necrosis factor inhibitor (TNFi) therapy and changes in C-reactive protein (CRP), blood pressure, and alanine aminotransferase (ALT) among patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis.
Topics: Alanine Transaminase; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Pressure; C-Reactive Protein; Cohort Studies; Humans; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Tumor Necrosis Factor-alpha | 2015 |
Methotrexate-related primary hepatic lymphoma in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Neoplasms; Lymphoma, B-Cell; Methotrexate; Middle Aged; Positron-Emission Tomography; Tomography, X-Ray Computed; Treatment Outcome | 2015 |
The effectiveness of risk communication regarding drug safety information: a nationwide survey by the Japanese public health insurance claims data.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Communication; Databases, Factual; Female; Humans; Insurance, Health; Japan; Logistic Models; Male; Methotrexate; Risk; Surveys and Questionnaires | 2015 |
Response to: 'drugs and cardiovascular risk in inflammatory arthritis: another case of glucocorticoid-bashing?' by Dr Boers.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Tumor Necrosis Factor-alpha | 2015 |
[Rheumatoid neutrophilic dermatitis].
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Dermatitis; Humans; Immunosuppressive Agents; Male; Methotrexate; Neutrophils; Treatment Outcome | 2015 |
Daily practice feasibility and effectiveness of treating long-standing rheumatoid arthritis to target with synthetic disease-modifying antirheumatic drugs: a prospective cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Feasibility Studies; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2015 |
Reduced folate carrier-1 80G > A gene polymorphism is not associated with methotrexate treatment response in South Indian Tamils with rheumatoid arthritis.
Topics: Adult; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Gene Frequency; Genotype; Heterozygote; Humans; India; Male; Methotrexate; Odds Ratio; Polyglutamic Acid; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Replication Protein C | 2016 |
Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry.
Topics: Abatacept; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Retrospective Studies; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2015 |
Editorial: treat to target in rheumatoid arthritis: good for the joints as well as the heart?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Patient Care Planning; Tumor Necrosis Factor-alpha | 2015 |
Methotrexate-induced nodulosis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Colchicine; Female; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule; Tubulin Modulators | 2015 |
Long-term use of methotrexate does not result in hepatitis B reactivation in rheumatologic patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; DNA, Viral; Female; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Spondylarthropathies; Time Factors; Viral Load; Virus Activation | 2015 |
[Effect of Sanhuang Yilong Decoction combined MTX on the expression of serum IL-1, IL-6, and IL-17 in rheumatoid arthritis patients of accumulated dampness-heat syndrome].
Topics: Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Drugs, Chinese Herbal; Hot Temperature; Humans; Interleukin-1; Interleukin-17; Interleukin-6; Methotrexate; Syndrome; Treatment Outcome | 2015 |
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.
Topics: Animals; Antibodies; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Combined Modality Therapy; Cytokines; Disease Models, Animal; Heat-Shock Proteins; Hyperthermia, Induced; Joints; Macrophage Activation; Macrophages; Methotrexate; Mice; NF-kappa B; STAT1 Transcription Factor; T-Lymphocytes | 2015 |
Cost-utility analysis of tocilizumab monotherapy in first line versus standard of care for the treatment of rheumatoid arthritis in Greece.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Female; Greece; Humans; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Retreatment; Standard of Care; Treatment Outcome | 2015 |
Early therapeutic intervention with methotrexate prevents the development of rheumatoid arthritis in patients with recent-onset undifferentiated arthritis: A prospective cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Cohort Studies; Epitopes; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Risk Factors; Smoking; Treatment Outcome | 2015 |
Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats.
Topics: Animals; Antioxidants; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Collagen; Cytokines; Inflammation; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Roots; Rats, Wistar; Withania | 2015 |
Comparative effectiveness of tocilizumab with either methotrexate or leflunomide in the treatment of rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Neutropenia; Retrospective Studies; Treatment Outcome | 2015 |
Effects of Concomitant Methotrexate on Large Joint Replacement in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors: A Multicenter Retrospective Cohort Study in Japan.
Topics: Adult; Aged; Analysis of Variance; Antibodies, Monoclonal; Arthritis, Rheumatoid; Arthroplasty, Replacement; Cohort Studies; Combined Modality Therapy; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Japan; Joint Prosthesis; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2015 |
Improvement of large-joint ultrasonographic synovitis is delayed in patients with newly diagnosed rheumatoid arthritis: results of a 12-month clinical and ultrasonographic follow-up study of a local cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Joints; Male; Methotrexate; Methylprednisolone; Middle Aged; Prednisolone; Severity of Illness Index; Synovitis; Treatment Outcome; Ultrasonography, Doppler | 2015 |
Longterm efficacy and safety of abatacept in patients with rheumatoid arthritis treated in routine clinical practice: effect of concomitant methotrexate after 24 weeks.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Remission Induction; Severity of Illness Index; Treatment Outcome | 2015 |
Predictors of longterm changes in body mass index in rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Hospitals, Veterans; Humans; Linear Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisone; Registries; Risk Assessment; Sex Factors; Time Factors; Treatment Outcome; United States; Weight Loss | 2015 |
Assessment of the Effect of Methotrexate Therapy on Bone Metabolism in Patients with Rheumatoid Arthritis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Bone and Bones; Bone Morphogenetic Proteins; Disease Progression; Female; Genetic Markers; Humans; Intercellular Signaling Peptides and Proteins; Methotrexate; Middle Aged; Osteoprotegerin; RANK Ligand | 2015 |
Periodontitis and Porphyromonas gingivalis in preclinical stage of arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biofilms; Cohort Studies; Female; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Periodontitis; Porphyromonas gingivalis; Proportional Hazards Models; Prospective Studies; Risk; Severity of Illness Index | 2015 |
Primary central nervous system lymphoma in a rheumatoid arthritis patient treated with methotrexate: a case report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2015 |
Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: A retrospective analysis of real-world data from the St. Gallen cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Treatment Outcome | 2015 |
Associations of rheumatoid factor and anti-citrullinated peptide antibody with disease progression and treatment outcomes in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2015 |
Rheumatoid arthritis: IL-6 inhibition in RA--déjà vu all over again?
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Interleukin-6 Receptor alpha Subunit; Male; Methotrexate | 2015 |
Brief Report: Miscarriages in Female Rheumatoid Arthritis Patients: Associations With Serologic Findings, Disease Activity, and Antirheumatic Drug Treatment.
Topics: Abortion, Spontaneous; Adult; Age Factors; Antibodies, Anti-Idiotypic; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Humans; Incidence; Live Birth; Logistic Models; Methotrexate; Netherlands; Peptides, Cyclic; Pregnancy; Pregnancy Outcome; Pregnancy Rate; Prospective Studies; Retrospective Studies; Severity of Illness Index | 2015 |
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
The rate of decrease in the disease activity of rheumatoid arthritis during treatment with adalimumab depends on the dose of methotrexate.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2015 |
Rheumatoid lung.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pleural Effusion; Pleurodesis; Pneumothorax; Prednisolone; Pulmonary Fibrosis; Sulfasalazine | 2015 |
Significance of liver biopsy for the evaluation of methotrexate-induced liver damage in patients with rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Methotrexate; Severity of Illness Index | 2015 |
Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Gold; Humans; Metal Nanoparticles; Methotrexate; Nanospheres; Polymers; Temperature; Theranostic Nanomedicine | 2015 |
The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Comparative Effectiveness Research; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prospective Studies; Remission Induction; Severity of Illness Index; Time Factors; Treatment Failure | 2016 |
Mycobacterium abscessus Pulmonary Infection under Treatment with Tocilizumab.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Middle Aged; Mycobacterium Infections, Nontuberculous; Opportunistic Infections; Respiratory Tract Infections; Treatment Outcome | 2015 |
Interplay between patient global assessment, pain, and fatigue and influence of other clinical disease activity measures in patients with active rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Denmark; Fatigue; Female; Humans; Male; Methotrexate; Middle Aged; Pain; Pain Measurement; Prednisolone; Registries; Reproducibility of Results; Rheumatology; Severity of Illness Index; Visual Analog Scale | 2015 |
Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Tacrolimus; Treatment Outcome | 2015 |
Isotypes of Epstein-Barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Viral; Antigens, Viral; Arthritis, Rheumatoid; Citrulline; Epstein-Barr Virus Nuclear Antigens; Female; Herpesvirus 4, Human; Humans; Immunoglobulin Isotypes; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Young Adult | 2015 |
Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Contrast Media; Delayed-Action Preparations; Diffusion; Gold; Iron; Light; Magnetic Fields; Male; Metal Nanoparticles; Methotrexate; Mice; Mice, Inbred DBA; Molecular Imaging; Nanocapsules; Particle Size; Photochemotherapy; Photosensitizing Agents; Surface Plasmon Resonance; Theranostic Nanomedicine; Treatment Outcome | 2015 |
Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Gene Expression; Healthy Volunteers; Humans; Leukocytes, Mononuclear; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Proton-Coupled Folate Transporter; Real-Time Polymerase Chain Reaction; Severity of Illness Index | 2015 |
Chikungunya infection in the general population and in patients with rheumatoid arthritis on biological therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Biological Therapy; Chikungunya Fever; Disease Outbreaks; Dominican Republic; Female; Humans; Male; Methotrexate; Middle Aged; Musculoskeletal Diseases; Steroids | 2015 |
Herpes Zoster Reactivation in Patients With Rheumatoid Arthritis: Analysis of Disease Characteristics and Disease-Modifying Antirheumatic Drugs.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Incidence; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Prednisone; Proportional Hazards Models; Registries; Risk Assessment; Risk Factors; Time Factors; Tumor Necrosis Factor-alpha; United States; Virus Activation | 2015 |
Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Cytokines; Developing Countries; Drug Therapy, Combination; Genotype; Humans; Inflammation Mediators; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Prospective Studies; Risk Factors; Smoking; South Africa; Time Factors; Treatment Outcome | 2015 |
Methotrexate-associated Lymphoproliferative Disease with Multiple Pulmonary Nodules in a Patient with Rheumatoid Arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate; Multiple Pulmonary Nodules | 2015 |
Cerebral toxoplasmosis in a patient on methotrexate and infliximab for rheumatoid arthritis.
Topics: Aged; Animals; Arthritis, Rheumatoid; Cats; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Methotrexate; Toxoplasmosis, Cerebral | 2015 |
Anti inflammatory effect of thymoquinone in comparison with methotrexate on pristane induced arthritis in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Body Weight; Female; Foot Joints; Immunosuppressive Agents; Inflammation; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes | 2015 |
Efficacy and safety of a biosimilar rituximab in biologic naïve patients with active rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biosimilar Pharmaceuticals; Blood Sedimentation; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Rituximab; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2015 |
Treatment Patterns of Multimorbid Patients with Rheumatoid Arthritis: Results from an International Cross-sectional Study.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Severity of Illness Index; Treatment Outcome; United States | 2015 |
The usefulness of a new triple combination treatment utilizing methotrexate, salazosulfapyridine, and bucillamine in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cysteine; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 2016 |
[Rheumatoid arthritis and lung - more than a minor aspect of the disease].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Evidence-Based Medicine; Humans; Lung Diseases, Interstitial; Methotrexate; Pneumonia; Treatment Outcome | 2015 |
Power Doppler ultrasound monitoring of response to anti-tumour necrosis factor alpha treatment in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Etanercept; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Sensitivity and Specificity; Treatment Outcome; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler; Visual Analog Scale | 2015 |
Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Female; Genotype; Humans; India; Male; Methotrexate; Phenotype; Polymorphism, Genetic; Severity of Illness Index; White People | 2015 |
ACP Journal Club. Review: In rheumatoid arthritis, adding rituximab to methotrexate improves clinical outcomes.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Rituximab | 2015 |
Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway.
Topics: Adult; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Female; Ferredoxin-NADP Reductase; Genotype; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Tunisia | 2016 |
Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Pharmacogenetics; Polymorphism, Single Nucleotide | 2015 |
Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cross-Sectional Studies; Erythrocytes; Female; Fibrosis; Humans; Lung Diseases, Interstitial; Methotrexate; Middle Aged; Peptides, Cyclic; Severity of Illness Index; Young Adult | 2015 |
Methotrexate, Cyclosporine A, and Biologics Protect against Atherosclerosis in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Biological Products; Carotid Intima-Media Thickness; Case-Control Studies; Cyclosporine; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prevalence; Severity of Illness Index | 2015 |
Detection of bone erosions in early rheumatoid arthritis: 3D ultrasonography versus computed tomography.
Topics: Adult; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Hand; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Synovitis; Tomography, X-Ray Computed; Ultrasonography; Wrist Joint | 2015 |
Does a family history of RA influence the clinical presentation and treatment response in RA?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Humans; Male; Medical Record Linkage; Methotrexate; Middle Aged; Prognosis; Registries; Severity of Illness Index; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Response to 'Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis'.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate | 2015 |
Reversible Methotrexate-Induced Dementia: A Case Report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dementia; Humans; Male; Methotrexate | 2015 |
Etanercept-Methotrexate Combination Therapy Initiators Have Greater Adherence and Persistence Than Triple Therapy Initiators With Rheumatoid Arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Etanercept; Female; Humans; Hydroxychloroquine; Logistic Models; Male; Medicare Part B; Medication Adherence; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Retrospective Studies; Sulfasalazine; Time Factors; Treatment Outcome; United States; Young Adult | 2015 |
Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Bone Density; Disease Progression; Female; Germany; Hand Joints; Humans; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Radiographic Image Interpretation, Computer-Assisted; Retrospective Studies; Time Factors; Treatment Outcome | 2015 |
Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Dependovirus; Gene Expression; Genes, Synthetic; Genetic Therapy; Genetic Vectors; Humans; Injections, Intra-Articular; Interferon-beta; Macaca mulatta; Male; Methotrexate; Mice; Mice, Inbred DBA; NF-kappa B; Promoter Regions, Genetic; Rabbits; Rats; Rats, Inbred Lew; Specific Pathogen-Free Organisms; Synovial Membrane; Tissue Distribution; Transduction, Genetic | 2015 |
Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Therapeutic effect of methotrexate encapsulated in cationic liposomes (EndoMTX) in comparison to free methotrexate in an antigen-induced arthritis study in vivo.
Topics: Administration, Intravenous; Animals; Antigens, Bacterial; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Blood Platelets; Capsules; Cell Communication; Disease Models, Animal; Endothelial Cells; Female; Knee Joint; Leukocytes; Liposomes; Methotrexate; Mice; Mice, Inbred C57BL; Microcirculation; Radiography; Treatment Outcome | 2015 |
Response to 'Feasibility of tailored treatment based on risk stratification in patients with early rheumatoid arthritis'--authors' reply.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate | 2015 |
Comparison of golimumab 100-mg monotherapy to golimumab 50 mg plus methotrexate in patients with rheumatoid arthritis: Results from a multicenter, cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2016 |
Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Chromones; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Registries; Remission Induction; Retrospective Studies; Severity of Illness Index; Sulfonamides; Treatment Outcome | 2016 |
Co-occurrence of rheumatoid arthritis and sarcoidosis.
Topics: Adrenal Cortex Hormones; Adult; Ankle Joint; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Methotrexate; Remission Induction; Sarcoidosis; Tomography, X-Ray Computed; Wrist Joint | 2015 |
Isolated herpes simplex in the adult larynx as a rare complication of methotrexate-induced immunosuppression.
Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; Arthritis, Rheumatoid; Female; Herpes Simplex; Humans; Immunosuppressive Agents; Laryngeal Diseases; Methotrexate | 2015 |
[Focusing on the use of biologics in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Contraindications; Humans; Latent Tuberculosis; Methotrexate; Neoplasms; Tumor Necrosis Factor-alpha; Vaccination | 2015 |
Methotrexate-induced Accelerated Pulmonary Nodulosis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Multiple Pulmonary Nodules | 2015 |
Low-dose methotrexate-induced skin toxicity: Keratinocyte dystrophy as a histologic marker.
Topics: Administration, Oral; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Biomarkers; Biopsy, Needle; Cohort Studies; Dose-Response Relationship, Drug; Drug Eruptions; Female; Follow-Up Studies; Humans; Immunohistochemistry; Keratinocytes; Male; Methotrexate; Middle Aged; Pemphigoid, Bullous; Psoriasis; Rare Diseases; Retrospective Studies; Risk Assessment; Skin Ulcer | 2015 |
Prescribing Patterns of Intravenous Golimumab for Rheumatoid Arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; United States | 2015 |
Brief report: enhancement of patient recruitment in rheumatoid arthritis clinical trials using a multi-biomarker disease activity score as an inclusion criterion.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Patient Selection; Severity of Illness Index | 2015 |
The role of methotrexate and low-dose prednisolone on adiponectine levels and insulin resistance in patients with rheumatoid arthritis naïve to disease-modifying antirheumatic drugs.
Topics: Adiponectin; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Glucose; Drug Therapy, Combination; Female; Humans; Insulin; Insulin Resistance; Male; Methotrexate; Middle Aged; Prednisolone; Time Factors; Treatment Outcome; Up-Regulation | 2016 |
[18F]fluorodeoxyglucose uptake as a predictor of large joint destruction in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Fluorodeoxyglucose F18; Foot Joints; Hand Joints; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Radionuclide Imaging; Retrospective Studies | 2016 |
Total cholesterol, lipoprotein, and triglyceride levels in tumor necrosis factor inhibitor-treated patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Cholesterol; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Lipoproteins, HDL; Lipoproteins, LDL; Methotrexate; Psoriasis; Retrospective Studies; Triglycerides; Tumor Necrosis Factor-alpha | 2015 |
Palindromic Rheumatism: An Unusual Cause of Chronic Intermittent Arthritis.
Topics: Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Chronic Disease; Humans; Male; Methotrexate; Middle Aged | 2015 |
Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Population Surveillance; Quebec; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
[Effect of Combination Therapy of Tetramethylpyrazine with Methotrexate on Inflammatory Reac- tions and Hemorheology in Collagen-induced Arthritis Rats].
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cattle; Collagen Type II; Drug Therapy, Combination; Drugs, Chinese Herbal; Hemorheology; Interleukin-17; Interleukin-1beta; Interleukin-6; Male; Methotrexate; Pyrazines; Rats; Rats, Sprague-Dawley; Synovial Membrane | 2015 |
Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Autoantibodies; Cohort Studies; Disease Progression; Female; Finger Joint; Foot Joints; Hand Joints; HLA-DRB1 Chains; Humans; Japan; Linear Models; Male; Methotrexate; Middle Aged; Netherlands; Peptides, Cyclic; Radiography; Rheumatoid Factor; Severity of Illness Index; White People | 2015 |
Comparison of the efficacies of abatacept and tocilizumab in patients with rheumatoid arthritis by propensity score matching.
Topics: Abatacept; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Propensity Score; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome | 2016 |
Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis and Low Cardiovascular Risk: The Role of von Willebrand Factor Activity.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Early Diagnosis; Female; Humans; Methotrexate; Middle Aged; Risk Factors; von Willebrand Factor | 2015 |
Primary Adrenal Lymphoma Possibly Associated With Epstein-Barr Virus Reactivation Due to Immunosuppression Under Methotrexate Therapy.
Topics: Adrenal Gland Neoplasms; Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Lymphoma; Male; Methotrexate; Virus Activation | 2015 |
Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis.
Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Female; Genetic Predisposition to Disease; HLA-DRB1 Chains; Humans; Logistic Models; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Risk Factors; Smoking; Texas | 2015 |
[1,25(OH)2-Vitamin-D3 attenuates Th17-related cytokines expression in peripheral blood mononuclear cells in patients with early-diagnosed rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cholecalciferol; Cytokines; Dose-Response Relationship, Drug; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; RNA, Messenger; Th17 Cells; Tumor Necrosis Factor-alpha; Vitamin D; Vitamins | 2015 |
Comparison of the Therapeutic Effects of Thymoquinone and Methotrexate on Renal Injury in Pristane Induced Arthritis in Rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Creatinine; Female; Humans; Inflammation; Kidney; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes; Urea | 2015 |
Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Peptides, Cyclic; Randomized Controlled Trials as Topic; Rheumatoid Factor; Rituximab; Severity of Illness Index | 2015 |
MRI evidence of persistent joint inflammation and progressive joint damage despite clinical remission during treatment of early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Edema; Etanercept; Female; Glucocorticoids; Hand Bones; Humans; Inflammation; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Prednisolone; Prognosis; Remission Induction; Severity of Illness Index; Synovitis; Tenosynovitis; Wrist Joint | 2016 |
Methotrexate-Induced Cutaneous Erosions.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Lip; Methotrexate; Skin Ulcer; Ulcer | 2016 |
Disease flares in rheumatoid arthritis are associated with joint damage progression and disability: 10-year results from the BeSt study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Follow-Up Studies; Humans; Joints; Methotrexate; Netherlands; Pain; Pain Measurement; Recurrence; Registries; Severity of Illness Index; Surveys and Questionnaires; Time Factors | 2015 |
Spontaneous Regression of Methotrexate-related Lymphoproliferative Disorder with T-cell Large Granular Lymphocytosis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphocytosis; Lymphoproliferative Disorders; Methotrexate; Prognosis; Remission, Spontaneous; T-Lymphocytes | 2015 |
Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Cell Cycle Proteins; Chromatography, High Pressure Liquid; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Mixed Function Oxygenases; Nuclear Proteins; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; T-Lymphocytes; Time Factors | 2015 |
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Linear Models; Male; Methotrexate; Middle Aged; Phosphopyruvate Hydratase; RANK Ligand; Synovial Membrane; Time Factors; Vimentin | 2015 |
[What methotrexate dose is optimal in combination with adalimumab?].
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate | 2015 |
Lack of association between CXCL9 and CXCL10 gene polymorphisms and the outcome of rheumatoid arthritis treatment with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemokine CXCL10; Chemokine CXCL9; Drug Therapy, Combination; Female; Genotype; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Treatment Outcome | 2015 |
Identification of 7 Proteins in Sera of RA Patients with Potential to Predict ETA/MTX Treatment Response.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Proteins; Drug Monitoring; Etanercept; Humans; Methotrexate; Sensitivity and Specificity | 2015 |
Safety and retention of combination triple disease-modifying anti-rheumatic drugs in new-onset rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Sulfasalazine; Treatment Outcome; United States | 2015 |
Superficial Tissue Necrosis Related to Methotrexate Injection in a Patient With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Humans; Male; Methotrexate; Middle Aged | 2015 |
Treatment of rheumatoid arthritis by molecular-targeted agents: efficacy and limitations.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Molecular Targeted Therapy; Pain Measurement; Randomized Controlled Trials as Topic; Risk Assessment; Time Factors; Treatment Outcome | 2015 |
Short Communication: Lack of association between MTHFR gene polymorphisms and response to methotrexate treatment in Pakistani patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies | 2015 |
Prednisone Use and Risk of Mortality in Patients With Rheumatoid Arthritis: Moderation by Use of Disease-Modifying Antirheumatic Drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Long Term Adverse Effects; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prednisone; Propensity Score; Proportional Hazards Models; Prospective Studies; Risk Factors; Sulfasalazine; Time Factors; Treatment Outcome | 2016 |
Serum survivin predicts responses to treatment in active rheumatoid arthritis: a post hoc analysis from the SWEFOT trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Inhibitor of Apoptosis Proteins; Male; Methotrexate; Middle Aged; Proto-Oncogene Mas; Randomized Controlled Trials as Topic; Sulfasalazine; Survivin; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Line; Chemistry, Pharmaceutical; Dexamethasone; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Immunohistochemistry; Injections, Intra-Articular; Male; Methotrexate; Mice; Rats; Spectroscopy, Near-Infrared; X-Ray Microtomography | 2015 |
Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors.
Topics: Adult; Analysis of Variance; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Radiography; Recovery of Function; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Hypercalcemia and Lytic Bone Lesions Masquerading Inflammatory Arthritis Treated as Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Female; Humans; Hydroxychloroquine; Hypercalcemia; Hyperparathyroidism; Methotrexate; Middle Aged; Parathyroidectomy; Rheumatoid Factor | 2015 |
Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Genotype; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Polymorphism, Genetic; Tumor Necrosis Factor-alpha | 2016 |
Methotrexate-associated lymphoproliferative disorder presenting as extranodal NK/T-cell lymphoma arising in the lungs.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Asparaginase; Diagnosis, Differential; Epstein-Barr Virus Infections; Etoposide; Female; Herpesvirus 4, Human; Humans; Ifosfamide; Lymphoma, Extranodal NK-T-Cell; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Risk; Steroids | 2015 |
Decernotinib: A Next-Generation Jakinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Heterocyclic Compounds, 2-Ring; Humans; Male; Methotrexate; Valine | 2016 |
Severe apoptotic enteropathy caused by methotrexate treatment for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biopsy; Colitis; Diarrhea; Humans; Intestinal Mucosa; Male; Methotrexate | 2016 |
Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice.
Topics: Animals; Arthritis, Rheumatoid; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Liposomes; Macrophages; Male; Methotrexate; Mice | 2015 |
The development of a questionnaire to evaluate rheumatoid arthritis patient's knowledge about methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Awareness; Cohort Studies; Cross-Sectional Studies; Female; France; Health Knowledge, Attitudes, Practice; Humans; Life Style; Male; Methotrexate; Middle Aged; Risk; Surveys and Questionnaires | 2016 |
Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Chitosan; Chromatography, High Pressure Liquid; Cytokines; Drug Carriers; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Methotrexate; Nanoparticles; Oligodeoxyribonucleotides; Oligonucleotides; Polysaccharides; Sialic Acids | 2015 |
Do we need to lower the cut point of the 2010 ACR/EULAR classification criteria for diagnosing rheumatoid arthritis?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Early Diagnosis; False Positive Reactions; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Sensitivity and Specificity; Severity of Illness Index | 2016 |
Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model.
Topics: Animals; Arthritis, Rheumatoid; Chronic Disease; Disease Models, Animal; Drug Carriers; Humans; Inflammation; Interferon-gamma; Interleukin-17; Lipids; Methotrexate; Nanocapsules; Rats; Synovial Membrane; T-Lymphocytes | 2015 |
Twelve-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: Real-Life Data From a Local Registry.
Topics: Adalimumab; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Humans; Infliximab; Italy; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Propensity Score; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Time Factors; Treatment Failure; Tumor Necrosis Factor-alpha | 2016 |
A case of rheumatoid arthritis with methotrexate related lymphoproliferative diseases of the knee.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Knee; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 2018 |
Multiple Intestinal Ulcers Associated with Primary Epstein-Barr Virus Infection in a Patient with Rheumatoid Arthritis Undergoing Methotrexate Therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Ileal Diseases; Ileum; Immunocompromised Host; Intestinal Diseases; Intestinal Mucosa; Methotrexate; Treatment Outcome; Ulcer | 2015 |
Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.
Topics: Arthritis, Rheumatoid; Biomarkers; Cell Line; Down-Regulation; Female; Humans; I-kappa B Proteins; Male; Methotrexate; NF-kappa B; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins; Reduced Folate Carrier Protein; Synovial Membrane | 2016 |
Severe Disability in a Patient With Rheumatoid Arthritis and Sickle Cell Anemia: An Underreported, But Yet a Potentially Treatable Combination of Diseases.
Topics: Anemia, Sickle Cell; Arthritis, Rheumatoid; Arthrography; Diagnostic Errors; Disability Evaluation; Disease Management; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome; Young Adult | 2015 |
Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cross-Sectional Studies; Female; Folic Acid; Genotype; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Risk | 2015 |
Spontaneous remission of a large thyroid tumour.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Staging; Remission, Spontaneous; Thyroid Gland; Thyroid Neoplasms; Tomography, X-Ray Computed | 2016 |
Sarcoidosis of the vagina treated with methotrexate.
Topics: Aged; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Biopsy; Episiotomy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Sarcoidosis; Vagina; Vaginal Diseases | 2016 |
Can Methotrexate Prevent Knee Arthroplasties in Patients with Rheumatoid Arthritis?
Topics: Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Humans; Methotrexate | 2015 |
Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Blood Sedimentation; C-Reactive Protein; Cohort Studies; Female; Glucocorticoids; Humans; Japan; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Prognosis; Registries; Remission Induction; ROC Curve; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Survivin polymorphism is associated with disease activity in rheumatoid arthritis patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Genotype; Humans; Inhibitor of Apoptosis Proteins; Male; Methotrexate; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Survivin | 2016 |
Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Female; Glucosidases; Humans; Male; Methotrexate; Middle Aged; Peptide Synthases; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2016 |
[Clinical remission in rheumatoid arthritis. Data from the early arthritis cohort study CAPEA].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Glucocorticoids; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prevalence; Remission Induction; Risk Factors; Treatment Outcome | 2016 |
Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Proteins; Blood Sedimentation; Female; Humans; Infliximab; Interleukin-16; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Proteomics; Statistics as Topic; Treatment Outcome | 2016 |
Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autophagy; Blotting, Western; Cell Survival; Drug Resistance; Female; Fibroblasts; Flow Cytometry; HMGB1 Protein; Humans; Male; Methotrexate; Microscopy, Electron, Transmission; Middle Aged; RNA, Small Interfering; Synovial Membrane; Transfection | 2015 |
Time lag between the initiation of adalimumab after methotrexate correlates with the efficacy of adalimumab in rheumatoid arthritis patients.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome | 2016 |
Ultrasound-detected activity in rheumatoid arthritis on methotrexate therapy: Which joints and tendons should be assessed to predict unstable remission?
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Disability Evaluation; Female; Humans; Joints; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prospective Studies; Recurrence; Remission Induction; Synovitis; Tendons; Tenosynovitis; Time Factors; Treatment Outcome; Ultrasonography, Doppler | 2016 |
MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Biomarkers; Case-Control Studies; Humans; Leukocytes; Methotrexate; Multidrug Resistance-Associated Proteins; Remission Induction; Treatment Outcome | 2015 |
Tick-borne encephalitis (TBE) vaccine to medically immunosuppressed patients with rheumatoid arthritis: A prospective, open-label, multi-centre study.
Topics: Adult; Aged; Antibodies, Viral; Antibody Formation; Arthritis, Rheumatoid; Encephalitis, Tick-Borne; Female; Humans; Immunization, Secondary; Immunocompromised Host; Male; Methotrexate; Middle Aged; Prospective Studies; Tumor Necrosis Factor-alpha; Viral Vaccines | 2016 |
Utilization of Subcutaneous Methotrexate in Rheumatoid Arthritis Patients After Failure or Intolerance to Oral Methotrexate: A Multicenter Cohort Study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome | 2016 |
Methotrexate reduces HbA1c concentration but does not produce chronic accumulation of ZMP in patients with rheumatoid or psoriatic arthritis.
Topics: Adult; Aged; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Glucose; Chromatography, Liquid; Erythrocytes; Female; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Male; Methotrexate; Middle Aged; Prospective Studies; Ribonucleotides; Tandem Mass Spectrometry | 2016 |
Methotrexate-related lymphoproliferative disorder of the stomach in a patient with rheumatoid arthritis: a case of disease regression after methotrexate cessation.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Multimodal Imaging; Neoplasm Regression, Spontaneous; Positron-Emission Tomography; Stomach Neoplasms; Tomography, X-Ray Computed | 2016 |
Nanostructured lipid carrier mediates effective delivery of methotrexate to induce apoptosis of rheumatoid arthritis via NF-κB and FOXO1.
Topics: Administration, Cutaneous; Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cell Line; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Keratinocytes; Lipids; Methotrexate; Mice; Nanostructures; NF-kappa B; Particle Size; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Skin Absorption; Swine; U937 Cells | 2016 |
Determinants of methotrexate adherence in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged | 2016 |
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Pain; Pain Measurement; Sweden; Treatment Outcome | 2016 |
ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Ethnicity; Female; Genetic Association Studies; Humans; Hydroxymethyl and Formyl Transferases; India; Male; Methotrexate; Multienzyme Complexes; Mutation; Nucleotide Deaminases; Polymorphism, Single Nucleotide | 2016 |
Tumor Necrosis Factor-α Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Certolizumab Pegol; Cohort Studies; Cyclophosphamide; Etanercept; Female; Humans; Hydroxychloroquine; Hypertension; Incidence; Infliximab; Male; Methotrexate; Middle Aged; Minocycline; Penicillamine; Proportional Hazards Models; Retrospective Studies; Risk Factors; Sulfasalazine; Tumor Necrosis Factor-alpha | 2016 |
[Effect of 10-hydroxycamptotbecine on the expression of VEGF in rheumatoid arthritis synovial fibroblasts].
Topics: Arthritis, Rheumatoid; Camptothecin; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Methotrexate; Synovial Membrane; Vascular Endothelial Growth Factor A | 2015 |
Myeloid-related Protein 8/14 Levels in Rheumatoid Arthritis: Marker of Disease Activity and Response to Methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Calgranulin A; Calgranulin B; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2016 |
[Methotrexate - anchor drug in the treament of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2016 |
Tapering and discontinuation of TNF-α blockers without disease relapse using ultrasonography as a tool to identify patients with rheumatoid arthritis in clinical and histological remission.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Recurrence; Remission Induction; Tumor Necrosis Factor-alpha; Ultrasonography | 2016 |
Recently diagnosed rheumatoid arthritis patients benefit from a treat-to-target strategy: results from the DREAM registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Remission Induction; Severity of Illness Index; Treatment Outcome | 2016 |
[Immunodeficiency-associated Burkitt lymphoma developed in a patient receiving a long-term methotrexate therapy for rheumatoid arthritis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Burkitt Lymphoma; Cyclophosphamide; Doxorubicin; Female; Humans; Immunologic Deficiency Syndromes; Methotrexate; Middle Aged; Prednisone; Remission Induction; Treatment Outcome; Vincristine | 2016 |
Cytotoxic chemotherapy administration in the community: A case study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Community Health Nursing; Female; Humans; Methotrexate; Occupational Health; Safety Management | 2015 |
Brief Report: Intensification to Triple Therapy After Treatment With Nonbiologic Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis in the United States From 2009 to 2014.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Sulfasalazine; Time Factors; United States | 2016 |
A comparative analysis of two interferon-γ releasing assays to detect past tuberculosis infections in Japanese rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Interferon-gamma; Interferon-gamma Release Tests; Male; Methotrexate; Middle Aged; Sensitivity and Specificity; Tuberculin Test; Tuberculosis | 2016 |
Changes of glycosylation of IgG in rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Demography; Female; Fucose; Galactose; Glycosylation; Humans; Immunoglobulin G; Lectins; Male; Methotrexate; Middle Aged; N-Acetylneuraminic Acid | 2016 |
Ocular surface findings in patients with rheumatoid arthritis under methotrexate or biological agent therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Corneal Pachymetry; Eye; Female; Glucocorticoids; Humans; Indomethacin; Intraocular Pressure; Male; Methotrexate; Middle Aged; Tears; Tumor Necrosis Factor-alpha | 2017 |
The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Canada; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Remission Induction; Time Factors; Time-to-Treatment; Treatment Outcome | 2016 |
Changes in Body Mass Related to the Initiation of Disease-Modifying Therapies in Rheumatoid Arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Body Weight; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Tumor Necrosis Factor-alpha | 2016 |
Examining Time to Initiation of Biologic Disease-modifying Antirheumatic Drugs and Medication Adherence and Persistence Among Texas Medicaid Recipients With Rheumatoid Arthritis.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Hispanic or Latino; Humans; Isoxazoles; Leflunomide; Male; Medicaid; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Texas; United States; Young Adult | 2016 |
Air Bubbles in the Knee Joint.
Topics: Air; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Emphysema; Humans; Knee Joint; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed | 2016 |
Editorial: Lipid Changes With Different Antiinflammatory Regimens in Rheumatoid Arthritis: Developing a Pragmatic Approach to Complex Data.
Topics: Arthritis, Rheumatoid; Cholesterol; Etanercept; Female; Humans; Male; Methotrexate | 2016 |
Comparison of continuation rates with three TNFα antagonists (adalimumab, infliximab, etanercept) in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: Retrospective 10-year study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Glucocorticoids; Humans; Infliximab; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2016 |
Response to methotrexate predicts long-term patient-related outcomes in rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2016 |
MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy.
Topics: Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biomarkers; Disease Progression; Female; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Remission Induction; ROC Curve; Sensitivity and Specificity | 2016 |
Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies; Taiwan | 2016 |
Initial combination therapy versus step-up therapy in treatment to the target of remission in daily clinical practice in early rheumatoid arthritis patients: results from the DREAM registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Remission Induction | 2016 |
[Correction of an inflammatory process with an interleukin-1 inhibitor in the combination treatment of secondary osteoarthritis in the presence of comorbid condition].
Topics: Adult; Aged; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cartilage Oligomeric Matrix Protein; Combined Modality Therapy; Comorbidity; Female; Humans; Interleukin-1; Low-Level Light Therapy; Male; Methotrexate; Middle Aged; Osteoarthritis; Outcome Assessment, Health Care; Severity of Illness Index | 2015 |
Determining the Lowest Optimally Effective Methotrexate Dose for Individual RA Patients Using Their Dose Response Relation in a Tight Control Treatment Approach.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2016 |
Keratinocyte Dystrophy as a Marker of Low-Dose Methotrexate-Induced Skin Toxicity: Comment on the Clinical Image by Mönch et al.
Topics: Arthritis, Rheumatoid; Biomarkers; Humans; Keratinocytes; Methotrexate; Skin | 2016 |
Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Transport; Blood Sedimentation; Cholesterol; Female; Humans; Lipoproteins, HDL; Longitudinal Studies; Male; Methotrexate; Middle Aged; Serum | 2016 |
Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Orbital Diseases; Positron-Emission Tomography; Tomography, X-Ray Computed | 2016 |
Acquired reactive perforating collagenosis associated with systemic lupus erythematosus.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Back; Collagen Diseases; Epidermis; Etanercept; Face; Female; Fibrillar Collagens; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Methotrexate; Prednisolone; Skin Diseases | 2016 |
The facts about low dose methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Community Health Nursing; Female; Humans; Methotrexate; Occupational Health; Safety Management | 2016 |
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis.
Topics: Aged; Arthritis, Rheumatoid; Constriction, Pathologic; Endoscopy, Gastrointestinal; Humans; Ileum; Intestinal Obstruction; Male; Methotrexate; Prednisolone; Rheumatoid Factor; Rheumatoid Vasculitis | 2016 |
Predictors of remission, erosive disease and radiographic progression in a Colombian cohort of early onset rheumatoid arthritis: a 3-year follow-up study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Colombia; Disease Progression; Female; Follow-Up Studies; HLA-DRB1 Chains; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Prospective Studies; Radiography; Remission Induction; Rheumatoid Factor; Severity of Illness Index | 2016 |
Relation among anti-rheumatic drug therapy, CD14(+)CD16(+) blood monocytes and disease activity markers (DAS28 and US7 scores) in rheumatoid arthritis: A pilot study.
Topics: Adult; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; GPI-Linked Proteins; Humans; Lipopolysaccharide Receptors; Male; Methotrexate; Middle Aged; Monocytes; Pilot Projects; Prednisone; Receptors, IgG; Severity of Illness Index | 2016 |
Impact of 24 months of anti-TNF therapy versus methotrexate on body weight in patients with rheumatoid arthritis: a prospective observational study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Body Weight; Eating; Etanercept; Female; Humans; Italy; Logistic Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prospective Studies; Tumor Necrosis Factor-alpha | 2016 |
Frequency of methotrexate intolerance in rheumatoid arthritis patients using methotrexate intolerance severity score (MISS questionnaire).
Topics: Abdominal Pain; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Fatigue; Female; Humans; Methotrexate; Nausea; Surveys and Questionnaires; Vomiting | 2016 |
Postoperative Surgical Infection After Spinal Surgery in Rheumatoid Arthritis.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cefazolin; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Neurosurgical Procedures; Orthopedic Procedures; Prednisolone; Retrospective Studies; Risk Factors; Surgical Wound Infection | 2016 |
Reactivation of occult hepatitis B virus infection under treatment with abatacept: a case report.
Topics: Abatacept; Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Asymptomatic Infections; Biomarkers; DNA, Viral; Drug Monitoring; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infusions, Intravenous; Lamivudine; Male; Methotrexate; Treatment Outcome; Virus Activation | 2016 |
Bias? Not so fast.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Methotrexate | 2016 |
Acute exacerbation of interstitial pneumonia associated with rheumatoid arthritis during the course of treatment for Pneumocystis jirovecii pneumonia: a case report.
Topics: Acute Disease; Aged; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Etanercept; Fatal Outcome; Female; Humans; Lung Diseases, Interstitial; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Polymyxin B; Trimethoprim, Sulfamethoxazole Drug Combination | 2016 |
Long-term drug survival of biological agents in patients with rheumatoid arthritis in clinical practice.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies | 2016 |
Treatment of rheumatoid arthritis (RA) in India-how and by whom: results from a speciality clinic-use of low-dose methotrexate (MTX) was inexplicably suboptimal.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed Diagnosis; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; India; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Outcome | 2016 |
Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Folic Acid; Hematologic Diseases; Humans; Hypoalbuminemia; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Retrospective Studies; Rheumatic Diseases; Risk Factors; Serum Albumin | 2016 |
Agreement between Rheumatologist and Patient-reported Adherence to Methotrexate in a US Rheumatoid Arthritis Registry.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Health Surveys; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Physician-Patient Relations; Registries; Rheumatologists; Self Report | 2016 |
Impact of methotrexate dose on efficacy of adalimumab in Japanese patients with rheumatoid arthritis: Results from registered data analyses.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Monitoring; Drug Synergism; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2017 |
Efficacy of add-on tacrolimus on methotrexate to maintain clinical remission after rediscontinuation of a tumor necrosis factor inhibitor in rheumatoid arthritis patients who relapsed shortly after discontinuation of the same tumor necrosis factor inhibit
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Etanercept; Female; Humans; Infliximab; Japan; Longitudinal Studies; Male; Medication Therapy Management; Methotrexate; Middle Aged; Remission Induction; Tacrolimus; Treatment Outcome; Tumor Necrosis Factor-alpha; Withholding Treatment | 2017 |
The Impact of Low-Dose Disease-modifying Anti-rheumatics Drugs (DMARDs) on Bone Mineral Density of Premenopausal Women in Early Rheumatoid Arthritis.
Topics: Absorptiometry, Photon; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Bone Density; Female; Femur Neck; Humans; Lumbar Vertebrae; Methotrexate; Middle Aged; Premenopause; Retrospective Studies; Sulfasalazine; Treatment Outcome | 2016 |
Association Between Breast Cancer Recurrence and Immunosuppression in Rheumatoid Arthritis and Inflammatory Bowel Disease: A Cohort Study.
Topics: Adalimumab; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Breast Neoplasms; Cohort Studies; Etanercept; Female; Humans; Immunosuppressive Agents; Incidence; Inflammatory Bowel Diseases; Infliximab; Medicare; Mercaptopurine; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tumor Necrosis Factor-alpha; United States | 2016 |
Pneumocystis jirovecii pneumonia developed in a patient with rheumatoid arthritis after 14 weeks of iguratimod add-on to treatment with methotrexate and etanercept.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chromones; Drug Therapy, Combination; Etanercept; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Long Term Adverse Effects; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Sulfonamides | 2018 |
Disease-modifying anti-rheumatic drugs and non-melanoma skin cancer in inflammatory arthritis patients: a retrospective cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Skin Neoplasms | 2016 |
Changes in Ultrasonographic Vascularity Upon Initiation of Adalimumab Combination Therapy in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Hand Joints; Humans; Male; Metacarpophalangeal Joint; Metatarsophalangeal Joint; Methotrexate; Middle Aged; Neovascularization, Pathologic; Randomized Controlled Trials as Topic; Severity of Illness Index; Synovial Membrane; Ultrasonography, Doppler; Wrist Joint | 2016 |
Clinical-pharmacogenetic predictive models for MTX discontinuation due to adverse events in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Female; Genotype; Humans; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Nucleoside Transport Proteins; Pharmacogenomic Testing; Polymorphism, Genetic; Predictive Value of Tests; Proportional Hazards Models; Reduced Folate Carrier Protein; Thymidylate Synthase; Treatment Outcome | 2017 |
Why methotrexate suboptimal dosing is a potential source of bias in biologic drugs clinical trials.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate | 2016 |
Effectiveness of treatment with biologic- and disease-modifying antirheumatic drugs in rheumatoid arthritis patients in Colombia.
Topics: Abatacept; Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Child, Preschool; Chloroquine; Cohort Studies; Colombia; Etanercept; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Young Adult | 2016 |
Varicella-Zoster virus hip arthritis in a rheumatoid arthritis patient.
Topics: Antirheumatic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Female; Follow-Up Studies; Herpes Zoster; Herpesvirus 3, Human; Hip Joint; Humans; Immunocompromised Host; Methotrexate; Middle Aged; Rare Diseases; Risk Assessment; Treatment Outcome | 2017 |
Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis Patients-A Pilot Study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Death; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Olea; Oxidative Stress; Pilot Projects; Treatment Outcome | 2016 |
Persistence With Conventional Triple Therapy Versus a Tumor Necrosis Factor Inhibitor and Methotrexate in US Veterans With Rheumatoid Arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Databases, Factual; Drug Substitution; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Kaplan-Meier Estimate; Logistic Models; Male; Medication Adherence; Methotrexate; Middle Aged; Propensity Score; Retrospective Studies; Risk Factors; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United States; Veterans Health | 2017 |
Pregnancy Outcomes in the Tofacitinib Safety Databases for Rheumatoid Arthritis and Psoriasis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant, Newborn; Methotrexate; Piperidines; Pregnancy; Pregnancy Outcome; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Young Adult | 2016 |
Let's re-examine these MTX points once again.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2016 |
Beyond methotrexate monotherapy for early rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate | 2016 |
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Japan; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Remission Induction | 2016 |
Effects of TNF Inhibitors on Parathyroid Hormone and Wnt Signaling Antagonists in Rheumatoid Arthritis.
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Bone Remodeling; Bone Resorption; Certolizumab Pegol; Collagen Type I; Etanercept; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Osteoporosis; Parathyroid Hormone; Peptides; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Wnt Proteins; Wnt Signaling Pathway | 2016 |
Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Registries; Risk Factors; Treatment Outcome | 2016 |
Overexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Drug Resistance, Multiple; Female; Fibroblasts; Humans; Male; Methotrexate; Middle Aged; Osteoarthritis; Synovial Membrane | 2016 |
Efficacy and safety of an anti-CD20 monoclonal antibody (Reditux™) for the treatment of patients with moderate to severe rheumatoid arthritis following the failure of conventional synthetic disease-modifying anti-rheumatic drugs.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; India; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Severity of Illness Index; Treatment Outcome | 2016 |
Frequency of metabolic syndrome in Pakistani cohort of patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Pakistan; Young Adult | 2016 |
Tocilizumab use in pregnancy: Analysis of a global safety database including data from clinical trials and post-marketing data.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Humans; Maternal Exposure; Methotrexate; Middle Aged; Pregnancy; Pregnancy Outcome; Product Surveillance, Postmarketing; Risk Assessment; Young Adult | 2016 |
Improving patient-centred care for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Decision Making; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Methotrexate; Patient Participation; Patient-Centered Care; Quality Improvement; Sulfasalazine | 2016 |
Nonadherence to disease modifying antirheumatic drugs in the first year after diagnosis: comparing three adherence measures in early arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged | 2016 |
Good practice in shared care for inflammatory arthritis.
Topics: Arthritis, Rheumatoid; General Practice; Humans; Methotrexate; Pneumococcal Vaccines | 2016 |
Immunogenicity of tocilizumab in patients with rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Case-Control Studies; CD4-Positive T-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Immunogenetics; Male; Methotrexate; Middle Aged; Prospective Studies; Reference Values; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2017 |
Clinical manifestations of autoimmune disease-related non-Hodgkin lymphoma: a Korean single-center, retrospective clinical study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Autoimmune Diseases; Disease-Free Survival; Female; Humans; Immunosuppressive Agents; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Republic of Korea; Retrospective Studies | 2016 |
Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2017 |
The level of cytokines and expression of caspase genes in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Caspase 3; Caspase 6; Caspase 9; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Lymphocytes; Methotrexate; RNA, Messenger; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Effect of Adherence to Protocolized Targeted Intensifications of Disease-modifying Antirheumatic Drugs on Treatment Outcomes in Rheumatoid Arthritis: Results from an Australian Early Arthritis Cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Medication Adherence; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2016 |
Multifocal inflammatory demyelination in a patient with rheumatoid arthritis and treatment complications.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Demyelinating Diseases; Fatal Outcome; Female; Humans; Hydroxychloroquine; Methotrexate; Middle Aged | 2016 |
Cytomegalovirus Reactivation Induced Acute Hepatitis and Gastric Erosions in a Patient with Rheumatoid Arthritis under Treatment with an Anti-IL-6 Receptor Antibody, Tocilizumab.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Cytomegalovirus Infections; Female; Ganciclovir; Hepatitis; Humans; Methotrexate; Middle Aged; Stomach Ulcer | 2016 |
Prediction of the therapeutic response to methotrexate at 24 weeks by methotrexate-polyglutamates concentration in erythrocytes at 8 weeks in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid | 2017 |
Pharmacoeconomic analysis of biological disease modifying antirheumatic drugs in patients with rheumatoid arthritis based on real-world data from the IORRA observational cohort study in Japan.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Economics, Pharmaceutical; Etanercept; Female; Humans; Infliximab; Japan; Male; Methotrexate; Middle Aged; Models, Theoretical; Treatment Outcome | 2017 |
Measuring transaminases in patients with rheumatoid arthritis on weekly methotrexate: does timing of blood testing matter?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors; Transaminases | 2016 |
Effectiveness of Tumor Necrosis Factor Inhibitors in Combination with Various csDMARD in the Treatment of Rheumatoid Arthritis: Data from the DREAM Registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Registries; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Rheumatoid Factor; Severity of Illness Index; Sudan; Sulfasalazine; Sweden; Symptom Assessment; Young Adult | 2016 |
Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell- and Tissue-Based Therapy; Female; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymocytes; Tumor Necrosis Factor-alpha | 2016 |
Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression.
Topics: Aged; Arthritis, Rheumatoid; Down-Regulation; Female; Fibroblasts; HMGB1 Protein; Humans; Male; Methotrexate; Middle Aged; Synovial Membrane | 2016 |
[The Analysis of Efficacy of The Application of Interleukin-1 Inhibitor in the Complex Therapy of Secondary Osteoarthritis Taking Into Account the Dynamics of Clinical and Functional Indicators].
Topics: Adult; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Interleukin-1; Laser Therapy; Male; Methotrexate; Middle Aged; Osteoarthritis, Knee; Patient Acuity; Quality of Life; Recovery of Function; Treatment Outcome | 2016 |
MYC/BCL2 Double-hit Lymphoma in a Patient with Rheumatoid Arthritis Associated with Methotrexate Treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; In Situ Hybridization, Fluorescence; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Receptors, Interleukin-2 | 2016 |
Claims for disease-modifying therapy by Alberta non-insured health benefits clients.
Topics: Adolescent; Adult; Aged; Alberta; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Child, Preschool; Databases, Factual; Female; Humans; Incidence; Indians, North American; Infant; Infant, Newborn; Insurance Claim Review; Insurance Coverage; Insurance, Health; Inuit; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2016 |
The rapid kinetics of optimal treatment with subcutaneous methotrexate in early inflammatory arthritis: an observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Injections, Intra-Articular; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome | 2016 |
Genomic stratification by expression of HLA-DRB4 alleles identifies differential innate and adaptive immune transcriptional patterns - A strategy to detect predictors of methotrexate response in early rheumatoid arthritis.
Topics: Adaptive Immunity; Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genomics; HLA-DRB4 Chains; Humans; Immunity, Innate; Male; Methotrexate; Middle Aged; Young Adult | 2016 |
Severe acute pancytopaenia in a patient with rheumatoid arthritis complicated by fatal invasive pulmonary aspergillosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Fatal Outcome; Female; Folic Acid; Humans; Immunosuppressive Agents; Invasive Pulmonary Aspergillosis; Methotrexate; Middle Aged; Pancytopenia; Severity of Illness Index; Vitamin B Complex | 2017 |
A case of multiple hepatic lesions associated with methotrexate-associated lymphoproliferative disorder.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Liver; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Renal Insufficiency, Chronic | 2016 |
Methotrexate intolerance in the treatment of rheumatoid arthritis (RA): effect of adding caffeine to the management regimen.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Chocolate; Coffee; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; India; Male; Methotrexate; Middle Aged; Treatment Outcome; Xanthines | 2017 |
Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Humans; Malaysia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome; Vitamin B Complex | 2016 |
Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis C.
Topics: Aged; Arthritis, Rheumatoid; Databases, Factual; Female; Follow-Up Studies; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Registries | 2016 |
Proteome Analysis of Rheumatoid Arthritis Gut Mucosa.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Colon; Epithelial Cells; Female; Gene Expression Regulation; Humans; Intestinal Mucosa; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proteome; Tetrahydrofolate Dehydrogenase | 2017 |
Association of 63/91 length polymorphism in the DHFR gene major promoter with toxicity of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase | 2016 |
Age at natural menopause in women on long-term methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Age Factors; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Immunosuppressive Agents; Menopause, Premature; Methotrexate; Middle Aged | 2016 |
Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1ρ imaging.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cartilage; Cartilage, Articular; Certolizumab Pegol; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Reproducibility of Results; Surveys and Questionnaires; Time Factors; Tumor Necrosis Factor-alpha; Wrist | 2017 |
Case of primary cutaneous methotrexate-associated Hodgkin's lymphoma.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Hodgkin Disease; Humans; Methotrexate; Skin Neoplasms | 2017 |
Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therapeutic outcome.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Genotype; Haplotypes; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Precision Medicine | 2016 |
Investigation of a multi-biomarker disease activity score in rheumatoid arthritis by comparison with magnetic resonance imaging, computed tomography, ultrasonography, and radiography parameters of inflammation and damage.
Topics: Adalimumab; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Denmark; Disease Progression; Female; Humans; Joints; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Patient Acuity; Radiography; Remission Induction; Research Design; Statistics as Topic; Synovitis; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha; Ultrasonography | 2017 |
Comparative Assessment of the Different American College of Rheumatology/European League Against Rheumatism Remission Definitions for Rheumatoid Arthritis for Their Use as Clinical Trial End Points.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Endpoint Determination; Europe; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Remission Induction; Rheumatology; Societies, Medical; United States | 2017 |
Discordance between tender and swollen joint count as well as patient's and evaluator's global assessment may reduce likelihood of remission in patients with rheumatoid arthritis and psoriatic arthritis: data from the prospective multicentre NOR-DMARD stu
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Diagnostic Self Evaluation; Disability Evaluation; Edema; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Norway; Predictive Value of Tests; Prospective Studies; Registries; Remission Induction; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Fatal outcome of an Epstein-Barr virus positive mucocutaneous ulcer secondary to methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Hemorrhage; Herpesvirus 4, Human; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Palatine Tonsil; Tonsillar Neoplasms; Ulcer; Vasculitis | 2016 |
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Erythrocytes; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Humans; Japan; Male; Methotrexate; Middle Aged; Peptide Synthases; Polyglutamic Acid; Polymorphism, Genetic; Reduced Folate Carrier Protein | 2016 |
Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disease Progression; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome; Twins, Monozygotic; White People | 2016 |
Cost-effectiveness Analysis of Treatment Sequence Initiating With Etanercept Compared With Leflunomide in Rheumatoid Arthritis: Impact of Reduced Etanercept Cost With Patent Expiration in South Korea.
Topics: Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Cost-Benefit Analysis; Drug Costs; Etanercept; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Republic of Korea | 2016 |
Comparative utility of interferon-γ release assay, QuantiFERON
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Interferon-gamma Release Tests; Japan; Latent Tuberculosis; Male; Methotrexate; Middle Aged; Prospective Studies; Steroids; Tuberculin Test; Young Adult | 2016 |
Cost-effectiveness of clinical remission by treat to target strategy in established rheumatoid arthritis: results of the CREATE registry.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cost-Benefit Analysis; Databases, Factual; Female; Health Care Costs; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2016 |
The dimeric form of HLA-G molecule is associated with the response of early rheumatoid arthritis (ERA) patients to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; HLA-G Antigens; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2017 |
The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; Cathepsin K; Cell Differentiation; Drug Therapy, Combination; Female; Humans; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Methotrexate; Middle Aged; Osteoclasts; Prospective Studies; Real-Time Polymerase Chain Reaction; Ribonucleosides; Severity of Illness Index; Tacrolimus | 2017 |
Five-year Safety Data from 5 Clinical Trials of Subcutaneous Golimumab in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Injections, Subcutaneous; Methotrexate; Spondylitis, Ankylosing; Treatment Outcome | 2016 |
Sternoclavicular Joint Swelling in a Patient with Rheumatoid Arthritis.
Topics: Aged; Arthritis, Reactive; Arthritis, Rheumatoid; Biopsy, Needle; Edema; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lymphoproliferative Disorders; Methotrexate; Rare Diseases; Recovery of Function; Severity of Illness Index; Sternoclavicular Joint; Ultrasonography, Doppler; Withholding Treatment | 2016 |
Identifying Clinical Factors Associated With Low Disease Activity and Remission of Rheumatoid Arthritis During Pregnancy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Female; Humans; Logistic Models; Methotrexate; Multivariate Analysis; Prednisone; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Pregnancy Trimester, Third; Prospective Studies; Remission Induction; Severity of Illness Index; Sulfasalazine | 2017 |
Reanalysis of the Multi-Biomarker Disease Activity Score for Assessing Disease Activity in the Abatacept Versus Adalimumab Comparison in Biologic-Naive Rheumatoid Arthritis Subjects with Background Methotrexate Study: Comment on the Article by Fleischmann
Topics: Abatacept; Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Humans; Methotrexate | 2017 |
Intravascular lymphoma in a rheumatoid arthritis patient following short-term methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma; Methotrexate; Vascular Neoplasms | 2017 |
The Scottish Early Rheumatoid Arthritis (SERA) Study: an inception cohort and biobank.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Specimen Banks; Biomarkers; Cohort Studies; Disease Progression; Female; Foot; Hand; Humans; Male; Methotrexate; Middle Aged; Patient Acceptance of Health Care; Precision Medicine; Prognosis; Quality of Life; Radiography; Scotland; Severity of Illness Index; Specimen Handling; Translational Research, Biomedical | 2016 |
Serum progranulin levels in Hispanic rheumatoid arthritis patients treated with TNF antagonists: a prospective, observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Hispanic or Latino; Humans; Intercellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Prednisone; Progranulins; Prospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Risk of diabetes mellitus associated with disease-modifying antirheumatic drugs and statins in rheumatoid arthritis.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroquine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Longitudinal Studies; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Protective Factors; Risk Factors; United States | 2017 |
The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Receptor, Adenosine A2A; Rheumatoid Nodule | 2017 |
Prognostic factors of methotrexate-associated lymphoproliferative disorders associated with rheumatoid arthritis and plausible application of biological agents.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; DNA, Viral; Female; Herpesvirus 4, Human; Humans; Japan; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prognosis; Withholding Treatment | 2017 |
Nocebo effects in practice: methotrexate myths and misconceptions.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Knowledge, Attitudes, Practice; Humans; Methotrexate; Nocebo Effect; Therapeutic Misconception | 2016 |
Underuse of Methotrexate in the Treatment of Rheumatoid Arthritis: A National Analysis of Prescribing Practices in the US.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Databases, Factual; Drug Prescriptions; Drug Utilization Review; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; United States | 2017 |
Epstein-Barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated B cell lymphoproliferative disorders.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; CpG Islands; DNA Methylation; Epstein-Barr Virus Infections; Female; Genetic Markers; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Promoter Regions, Genetic; Treatment Outcome | 2017 |
Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases.
Topics: Adult; Age Factors; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Health Status; Humans; Kuwait; Male; Methotrexate; Middle Aged; Prevalence; Rheumatic Nodule; Severity of Illness Index; Sex Factors; Smoking | 2017 |
ATIC missense variant affects response to methotrexate treatment in rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase | 2016 |
Asymptomatic colitis induced by low-dose methotrexate.
Topics: Aged; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Colitis; Colonoscopy; Drug Therapy, Combination; Female; Humans; Incidental Findings; Leucovorin; Methotrexate; Metronidazole | 2016 |
Effect of iguratimod and methotrexate on RANKL and OPG expression in serum and IL-1β-induced fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Blotting, Western; Chromones; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Humans; Interleukin-1beta; Male; Methotrexate; Middle Aged; Osteoprotegerin; RANK Ligand; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Synoviocytes | 2016 |
Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats.
Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; C-Reactive Protein; Collagen Type II; Drug Chronotherapy; Female; Interleukin-6; Methotrexate; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2018 |
An Injectable, Click-Cross-Linked Small Intestinal Submucosa Drug Depot for the Treatment of Rheumatoid Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chondrocytes; Glycosaminoglycans; Injections; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mice; Rats; Rats, Inbred Lew; RAW 264.7 Cells | 2016 |
Five-year Efficacy and Safety of Tocilizumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Methotrexate- and Biologic-naive or Free of Methotrexate for 6 Months: the AMBITION Study.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2017 |
Aseptic inflammation of prosthetic knee in a patient affected by rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Female; Humans; Immunocompromised Host; Inflammation; Knee Joint; Methotrexate; Prosthesis-Related Infections; Radionuclide Imaging; Synovitis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Pulmonary Fibrosis; Registries; Regression Analysis; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United Kingdom | 2017 |
Drug survival on tumour necrosis factor inhibitors in patients with rheumatoid arthritis in Finland.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Monitoring; Drug Therapy, Combination; Etanercept; Female; Finland; Humans; Immunologic Factors; Longitudinal Studies; Male; Medication Adherence; Medication Therapy Management; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2017 |
Chronic hepatitis E in a patient with rheumatoid arthritis treated with adalimumab and methotrexate.
Topics: Adalimumab; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Hepatitis E; Hepatitis, Chronic; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Ribavirin | 2017 |
Maintenance of efficacy and safety with subcutaneous golimumab in rheumatoid arthritis patients with low disease activity who previously received TNF inhibitors.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Infliximab; Injections, Subcutaneous; Japan; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Folic Acid Supplementation Is Suboptimal in a National Cohort of Older Veterans Receiving Low Dose Oral Methotrexate.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Female; Folic Acid; Humans; Male; Methotrexate; Retrospective Studies; Veterans | 2016 |
Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Lymphomatoid Granulomatosis; Male; Methotrexate; Oral Ulcer | 2017 |
Cutaneous Merkel cell carcinoma: multiple asynchronous primary lesions in a patient on immunosuppressive therapy.
Topics: Abatacept; Arthritis, Rheumatoid; Biomarkers, Tumor; Carcinoma, Merkel Cell; Etanercept; Female; Humans; Immunocompromised Host; Immunohistochemistry; Immunosuppressive Agents; Methotrexate; Middle Aged; Neoplasms, Multiple Primary; Skin Neoplasms | 2017 |
A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Chitinase-3-Like Protein 1; Decision Support Techniques; Drug Therapy, Combination; Epidermal Growth Factor; Female; Humans; Hydroxychloroquine; Infliximab; Interleukin-6; Leptin; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor, Type I; Resistin; Serum Amyloid A Protein; Severity of Illness Index; Sulfasalazine; Treatment Failure; Treatment Outcome; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2017 |
Long-term use of biologic agents does not increase the risk of serious infections in elderly patients with rheumatoid arthritis.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Factors; Case-Control Studies; Chi-Square Distribution; Female; Glucocorticoids; Hospitalization; Humans; Incidence; Infections; Kaplan-Meier Estimate; Logistic Models; Male; Methotrexate; Prednisolone; Retrospective Studies; Risk; Statistics, Nonparametric | 2017 |
Biopsy-proven case of Epstein-Barr virus (EBV)-associated vasculitis of the central nervous system.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Brain; Central Nervous System; Epstein-Barr Virus Infections; Female; Humans; Immunosuppressive Agents; Methotrexate; Prednisolone; Vasculitis | 2017 |
Methotrexate-induced panniculitis in a patient with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Panniculitis | 2016 |
Risk and severity of herpes zoster in patients with rheumatoid arthritis receiving different immunosuppressive medications: a case-control study in Asia.
Topics: Abatacept; Adalimumab; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Case-Control Studies; Etanercept; Female; Herpes Zoster; Herpes Zoster Ophthalmicus; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Odds Ratio; Risk Factors; Rituximab; Severity of Illness Index; Sulfasalazine; Taiwan; Time Factors; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Factors influencing the choice of first- and second-line biologic therapy for the treatment of rheumatoid arthritis: real-life data from the Italian LORHEN Registry.
Topics: Abatacept; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Comorbidity; Drug Therapy, Combination; Female; Humans; Italy; Logistic Models; Male; Methotrexate; Middle Aged; Registries; Tumor Necrosis Factor-alpha | 2017 |
Methotrexate reduces vaccine-specific immunoglobulin levels but not numbers of circulating antibody-producing B cells in rheumatoid arthritis after vaccination with a conjugate pneumococcal vaccine.
Topics: Adult; Aged; Antibodies, Bacterial; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Enzyme-Linked Immunospot Assay; Female; Humans; Immunoglobulin A; Immunoglobulin G; Lymphocyte Count; Male; Methotrexate; Middle Aged; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Serogroup; Streptococcus pneumoniae; Vaccines, Conjugate | 2017 |
Preparation and evaluation of biopolymeric nanoparticles as drug delivery system in effective treatment of rheumatoid arthritis.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Rheumatoid; Biocompatible Materials; Cell Culture Techniques; Cell Line; Chitosan; Dexamethasone; Drug Delivery Systems; Drug Stability; Excipients; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Particle Size; Rats, Wistar; Surface Properties; Tissue Distribution | 2017 |
Arthrorheumatism with methotrexate-associated lymphoproliferative disorder in the brain.
Topics: Aged; Arthritis, Rheumatoid; Brain; Female; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Treatment Outcome | 2016 |
High Methotrexate Triglutamate Level Is an Independent Predictor of Adverse Effects in Asian Indian Rheumatoid Arthritis Patients-A Preliminary Study.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Drug-Related Side Effects and Adverse Reactions; Erythrocytes; Female; Humans; Male; Methotrexate; Polyglutamic Acid | 2017 |
Comment on "Efficacy and Treatment Costs of Monotherapy with bDMARDs in the Treatment of Rheumatoid Arthritis in Patients Intolerant to or Inappropriate to Continue Treatment with Methotrexate".
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Health Care Costs; Humans; Methotrexate; Treatment Outcome | 2017 |
Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis.
Topics: Abatacept; Adult; Aged; Anti-Citrullinated Protein Antibodies; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Rituximab; Tumor Necrosis Factor-alpha | 2017 |
IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Interleukin-22; Interleukins; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; T-Lymphocytes, Helper-Inducer; Treatment Outcome | 2017 |
Efficacy of golimumab for preventing large joint destruction in patients with rheumatoid arthritis as determined by the ARASHI score.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone | 2017 |
Left ventricular function at two-year follow-up in treatment-naive rheumatoid arthritis patients is associated with anti-cyclic citrullinated peptide antibody status: a cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Cohort Studies; Coronary Artery Disease; Denmark; Disease Progression; Echocardiography; Female; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Tomography, X-Ray Computed; Vascular Calcification; Ventricular Dysfunction, Left; Ventricular Function, Left | 2017 |
Phaeohyphomycotic tenosynovitis after local steroid injection during methotrexate therapy for rheumatoid arthritis: A case-report.
Topics: Arthritis, Rheumatoid; Combined Modality Therapy; Drainage; Follow-Up Studies; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Phaeohyphomycosis; Prednisone; Tenosynovitis; Treatment Outcome; Voriconazole; Wrist Joint | 2017 |
Medication errors associated with oral administration of methotrexate. Data from spontaneous reporting and medical literature review.
Topics: Administration, Oral; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Male; Medication Errors; Methotrexate; Middle Aged; Psoriasis; Spain | 2017 |
Association of IL17A and IL17F genes with rheumatoid arthritis disease and the impact of genetic polymorphisms on response to treatment.
Topics: Adult; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-17; Male; Methotrexate; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Prognosis; Risk Factors; Severity of Illness Index; Sex Factors; Treatment Outcome | 2017 |
Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cluster Analysis; Cohort Studies; Female; Gene Expression Profiling; Gene Regulatory Networks; Genetic Predisposition to Disease; Humans; Metalloendopeptidases; Methotrexate; Oligonucleotide Array Sequence Analysis; Receptor, ErbB-2; Sequence Analysis, RNA; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
Patients with Rheumatoid Arthritis in Remission While Receiving Etanercept Plus Methotrexate Therapy May Require Adjustment of Dosing Regimen When Switched to Methotrexate Monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Treatment Outcome | 2017 |
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Case-Control Studies; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Incidence; Leukemia, Myeloid, Acute; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Mycophenolic Acid; Myelodysplastic Syndromes; Odds Ratio; Psoriasis; Retrospective Studies; Risk Factors; United States | 2017 |
Atherosclerosis is not accelerated in rheumatoid arthritis of low activity or remission, regardless of antirheumatic treatment modalities.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Biological Factors; Carotid Artery Diseases; Carotid Intima-Media Thickness; Case-Control Studies; Disease Progression; Female; Femoral Artery; Humans; Male; Methotrexate; Middle Aged; Plaque, Atherosclerotic; Prednisolone; Vascular Stiffness | 2017 |
Distinct patterns of lymphocyte count transition in lymphoproliferative disorder in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Lymphocyte Count; Lymphopenia; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Retrospective Studies | 2017 |
Effects of antirheumatic drug underutilization on rheumatoid arthritis disease activity.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2017 |
Long term treatment with abatacept or tocilizumab does not increase Epstein-Barr virus load in patients with rheumatoid arthritis - A three years retrospective study.
Topics: Abatacept; Adult; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Real-Time Polymerase Chain Reaction; Retrospective Studies; Viral Load | 2017 |
Rapid healing of peripheral ulcerative keratitis in rheumatoid arthritis with prednisone, methotrexate and adalimumab combination therapy.
Topics: Adalimumab; Antirheumatic Agents; Arthritis, Rheumatoid; Corneal Ulcer; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2017 |
Impact of anti-TNF therapy on NK cells function and on immunosurveillance against B-cell lymphomas.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cell Degranulation; Cell Line, Tumor; Cells, Cultured; Child; Cytotoxicity, Immunologic; Female; Humans; Immunologic Surveillance; Immunosuppressive Agents; Immunotherapy; Interferon-gamma; Killer Cells, Natural; Lymphocyte Activation; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Risk; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2017 |
Brief Report: Clinical Trials Aiming to Prevent Rheumatoid Arthritis Cannot Detect Prevention Without Adequate Risk Stratification: A Trial of Methotrexate Versus Placebo in Undifferentiated Arthritis as an Example.
Topics: Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Decision Support Techniques; Humans; Kaplan-Meier Estimate; Methotrexate; Randomized Controlled Trials as Topic; Risk Assessment; Treatment Outcome | 2017 |
Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Serum Amyloid P-Component; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study.
Topics: Adalimumab; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome | 2017 |
Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Calcium Phosphates; Doxorubicin; Drug Carriers; Drug Liberation; Humans; Hyaluronic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Male; Methotrexate; Mice; Nanoparticles; Particle Size; Tissue Distribution | 2017 |
Patient-reported outcomes as predictors of remission in early rheumatoid arthritis patients treated with tight control treat-to-target approach.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Patient Reported Outcome Measures; Predictive Value of Tests; Prognosis; Quality of Life; Remission Induction; Severity of Illness Index; Treatment Outcome; Young Adult | 2017 |
No correlation between MTHFR c.677 C > T, MTHFR c.1298 A > C, and ABCB1 c.3435 C > T polymorphisms and methotrexate therapeutic outcome of rheumatoid arthritis in West Algerian population.
Topics: Adult; Aged; Algeria; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Black People; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Treatment Outcome | 2017 |
The impact on disability of initial treatment with methotrexate in patients with rheumatoid arthritis: results from the MARI study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2016 |
Application of fluorescence polarization immunoassay for determination of methotrexate-polyglutamates in rheumatoid arthritis patients.
Topics: Administration, Oral; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Fluorescence Polarization Immunoassay; Humans; Inflammation Mediators; Methotrexate; Polyglutamic Acid | 2008 |
Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Middle Aged; Skin Neoplasms | 2008 |
[Case of miliary tuberculosis during treatment with infliximab for rheumatoid arthritis].
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Infliximab; Methotrexate; Mycobacterium tuberculosis; Tuberculosis, Miliary | 2008 |
Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Gene Frequency; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Adenosine A2; Retrospective Studies; Treatment Outcome | 2008 |
Histoplasmosis clinically imitating cutaneous malignancy.
Topics: Aged; Antifungal Agents; Arthritis, Rheumatoid; Dermatitis, Seborrheic; Diagnosis, Differential; Histoplasmosis; Humans; Immunosuppressive Agents; Itraconazole; Keratosis, Actinic; Male; Methotrexate; Prednisone; Skin Neoplasms | 2008 |
Methotrexate and its effect on the anti-GAD titre in two patients with rheumatoid arthritis and diabetes mellitus.
Topics: Aged; Arthritis, Rheumatoid; Autoantibodies; Diabetes Mellitus, Type 2; Female; Glutamate Decarboxylase; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged | 2008 |
Reduction of serum interleukin 7 levels upon methotrexate therapy in early rheumatoid arthritis correlates with disease suppression.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Follow-Up Studies; Humans; Immunosuppressive Agents; Interleukin-7; Methotrexate; Treatment Outcome | 2008 |
Limitations of the study of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: comment on the article by Braun et al.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2008 |
Co-occurrence of subchondral insufficiency fracture of the femoral head and contralateral femoral neck fracture in a rheumatic patient receiving steroid treatment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Femoral Neck Fractures; Femur Head; Fractures, Stress; Hip Fractures; Hip Joint; Humans; Magnetic Resonance Imaging; Methotrexate; Osteonecrosis; Osteoporosis, Postmenopausal; Prednisolone | 2008 |
Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Female; Ferredoxin-NADP Reductase; Folic Acid; Humans; Male; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase | 2008 |
Patients with rheumatoid arthritis treated with methotrexate (MTX): concentrations of steady-state erythrocyte MTX correlate to plasma concentrations and clinical efficacy.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Erythrocytes; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Models, Biological; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2008 |
COMET's path, and the new biologicals in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Radiography; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Tumor necrosis factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Confounding Factors, Epidemiologic; Female; Heart Failure; Hospitalization; Humans; Male; Methotrexate; Proportional Hazards Models; Retrospective Studies; Risk; Tumor Necrosis Factor-alpha | 2008 |
Persistent clinical response of infliximab therapy in patients with refractory rheumatoid arthritis, over a 3-year period.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Infliximab; Magnetic Resonance Imaging; Methotrexate; Tumor Necrosis Factor-alpha | 2006 |
Rapid vanishing of tumors by withdrawal of methotrexate in Epstein-Barr virus-related B cell lymphoproliferative disorder.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Humans; Immune System; Lymphoma, B-Cell; Methotrexate; Mouth Neoplasms; Thoracic Neoplasms; Tomography, X-Ray Computed | 2008 |
Herpes zoster in patients taking TNFalpha antagonists for chronic inflammatory joint disease.
Topics: Acyclovir; Adalimumab; Adult; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Herpes Zoster; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Factors; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; Valacyclovir; Valine | 2008 |
Golimumab, a fully human monoclonal antibody against TNFalpha.
Topics: Adult; Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Asthma; Clinical Trials as Topic; Colitis, Ulcerative; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2008 |
[Fusion protein abatacept. Remission in every 5th TNF-alpha refractory patient].
Topics: Abatacept; Antigen-Presenting Cells; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Recurrence; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2008 |
Ascendancy of weekly low-dose methotrexate in usual care of rheumatoid arthritis from 1980 to 2004 at two sites in Finland and the United States.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Time Factors; Treatment Outcome | 2008 |
Folic acid supplements are good (not bad) for rheumatoid arthritis patients treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Food, Fortified; Humans; Methotrexate; Treatment Outcome | 2008 |
Treatment persistence with adalimumab, etanercept, or infliximab in combination with methotrexate and the effects on health care costs in patients with rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Etanercept; Female; Health Care Costs; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Treatment Outcome | 2008 |
[Is the guideline, "Management of early rheumatoid arthritis," being followed in a rheumatism center?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Drug Therapy, Combination; Folic Acid; Germany; Glucocorticoids; Guideline Adherence; Hospitals, Special; Humans; Methotrexate; Rheumatology; Vitamin B Complex; Vitamin D; Vitamins | 2008 |
Rheumatoid arthritis, alcohol, leflunomide and methotrexate. Can changes to the BSR guidelines for leflunomide and methotrexate on alcohol consumption be justified?
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Depressants; Contraindications; Databases, Factual; Ethanol; Female; Health Care Surveys; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Surveys and Questionnaires | 2008 |
Discordant perspectives of rheumatologists and patients on COBRA combination therapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Attitude to Health; Drug Therapy, Combination; Female; Focus Groups; Humans; Male; Methotrexate; Netherlands; Practice Patterns, Physicians'; Prednisolone; Sulfasalazine | 2008 |
Effects of infliximab therapy on biological markers of synovium activity and cartilage breakdown in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Collagen Type II; Cross-Linking Reagents; Disaccharides; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prospective Studies; Pyridines; Synovial Membrane; Treatment Outcome | 2009 |
Response of early active rheumatoid arthritis to tumor necrosis factor inhibitors: evaluation by magnetic resonance imaging.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Magnetic Resonance Imaging; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Effects of methotrexate use in a patient with rheumatoid arthritis and multiple sclerosis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunologic Factors; Interferon Type I; Methotrexate; Multiple Sclerosis; Recombinant Proteins | 2008 |
Development of autoimmune diseases after vaccination.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Giant Cell Arteritis; Humans; Influenza Vaccines; Male; Methotrexate; Prednisone; Tetanus Toxoid | 2008 |
Anti-TNF-alpha immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dental Plaque Index; Female; Gingival Hemorrhage; Gingivitis; Humans; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Smoking; Tumor Necrosis Factor-alpha | 2008 |
Effects of leflunomide and methotrexate in rheumatoid arthritis detected by digital X-ray radiogrammetry and computer-aided joint space analysis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Female; Finger Joint; Humans; Image Interpretation, Computer-Assisted; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Radiography | 2009 |
[Three cases of methotrexate-associated lymphoproliferative disorder (MTX-LPD)].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Methotrexate | 2008 |
RAPID3 (Routine Assessment of Patient Index Data 3), a rheumatoid arthritis index without formal joint counts for routine care: proposed severity categories compared to disease activity score and clinical disease activity index categories.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Glucocorticoids; Health Status Indicators; Humans; Male; Methotrexate; Middle Aged; Prednisone; Remission Induction; Severity of Illness Index; Surveys and Questionnaires | 2008 |
Eligibility of rheumatoid arthritis patients for anti-TNF-alpha therapy according to the 2005 recommendations of the French and British Societies for Rheumatology.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Eligibility Determination; Female; France; Health Planning Guidelines; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Rheumatology; Societies, Medical; Treatment Failure; Tumor Necrosis Factor-alpha; United Kingdom | 2008 |
Discontinuation of methotrexate therapy in older patients with newly diagnosed rheumatoid arthritis: analysis of administrative health databases in Québec, Canada.
Topics: Administration, Oral; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Databases, Factual; Female; Health Services for the Aged; Humans; Male; Medication Adherence; Methotrexate; Population Surveillance; Quebec; Rural Population; Treatment Outcome; Urban Population | 2008 |
Methotrexate is not associated with progression of interstitial lung disease in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Lung Diseases, Interstitial; Methotrexate | 2008 |
Variation of immunological response in methotrexate-induced pneumonitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Databases, Bibliographic; Drug Administration Schedule; Female; Humans; Lung; Lymphocytes; Male; Methotrexate; Middle Aged; Neutrophils; Pneumonia; Statistics, Nonparametric | 2008 |
Simultaneous appearance of methotrexate-associated lymphoproliferative disorder and tuberculous meningitis demonstrating the definitive role of immunosuppression.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunosuppression Therapy; Lymphoproliferative Disorders; Methotrexate; Tuberculosis, Meningeal | 2009 |
Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Immunologic Factors; Intercellular Signaling Peptides and Proteins; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Risk; Severity of Illness Index | 2008 |
Etanercept improved primary biliary cirrhosis associated with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Liver Cirrhosis, Biliary; Methotrexate; Middle Aged; Prednisolone; Receptors, Tumor Necrosis Factor; Treatment Outcome; Withholding Treatment | 2009 |
When patients with rheumatoid arthritis fail tumour necrosis factor inhibitors: what is the next step?
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Failure; Tumor Necrosis Factor-alpha | 2008 |
Methotrexate treatment of rheumatic diseases: can we do better?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2008 |
Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Erythrocytes; Female; Half-Life; Humans; Individuality; Male; Methotrexate; Middle Aged; Polyglutamic Acid | 2008 |
A 75-year-old man with significant bleeding after transbronchial biopsy.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Bronchi; Hemorrhage; Humans; Hydroxychloroquine; Male; Methotrexate | 2008 |
Generalized pustulosis induced by adalimumab in a patient with rheumatoid arthritis - a therapeutic challenge.
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Cyclosporine; Drug Eruptions; Drug Therapy, Combination; Epidermis; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Prednisolone | 2008 |
Differential influences of bucillamine and methotrexate on the generation of fibroblast-like cells from bone marrow CD34+ cells of rheumatoid arthritis patients.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD34; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Cells; Culture Media; Cysteine; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; Ilium; Immunosuppressive Agents; Indicators and Reagents; Matrix Metalloproteinase 1; Methotrexate; Middle Aged; Stem Cells; Vimentin | 2009 |
Polyradiculopathy due to methotrexate-induced ebv-associated lymphoproliferative disorder.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Polyradiculopathy | 2008 |
[Treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Tumor Necrosis Factor-alpha | 2008 |
Cost-effectiveness of sequential therapy with tumor necrosis factor antagonists in early rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
[Diagnosis and therapy of rheumatoid arthritis].
Topics: Adalimumab; Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Diagnosis, Differential; Early Diagnosis; Humans; Male; Methotrexate; Predictive Value of Tests; Rheumatoid Factor | 2008 |
[Aggressive non-Hodgkin lymphoma in 3 patients with rheumatoid arthritis: discontinue the use of methotrexate].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Remission, Spontaneous | 2008 |
Visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate.
Topics: Aged; Amphotericin B; Animals; Antiprotozoal Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Leishmania; Leishmaniasis, Visceral; Methotrexate; Splenectomy; Treatment Outcome | 2009 |
COMET results are not stellar.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benchmarking; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 2008 |
Subtle changes in individual joints result in both positive and negative change scores in a patient: results from a clinical trial in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Observer Variation; Receptors, Tumor Necrosis Factor; Reproducibility of Results; Treatment Outcome | 2009 |
American College of Rheumatology quality indicators for rheumatoid arthritis: benchmarking, variability, and opportunities to improve quality of care using the electronic health record.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Benchmarking; Clinical Competence; Data Collection; Female; Humans; Male; Medical Records Systems, Computerized; Methotrexate; Middle Aged; Quality of Health Care; Rheumatology; United States | 2008 |
[Attaching importance to the traditional disease modifying antirheumatic drugs].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2008 |
[Pneumocystis pneumonia among patients with systemic diseases].
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Cyclophosphamide; Drug Therapy, Combination; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Methotrexate; Opportunistic Infections; Pneumonia, Pneumocystis; Prednisone; Rheumatic Diseases | 2009 |
Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Genotype; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Immunosuppressive Agents; Male; Methotrexate; Polymorphism, Genetic; Treatment Outcome | 2009 |
Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians.
Topics: Adult; Arthritis, Rheumatoid; Asian People; Biological Availability; Demography; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; India; Male; Methotrexate; Multifactorial Inheritance; Polymorphism, Single Nucleotide; Treatment Outcome | 2008 |
[Undesirable effects of methothrexate during treatment of rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors | 2007 |
Pustular psoriasis following treatment of rheumatoid arthritis with TNF-alpha inhibitors.
Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Dermatologic Agents; Etanercept; Female; Flurandrenolone; Foot; Hand; Humans; Immunoglobulin G; Isotretinoin; Keratolytic Agents; Methotrexate; Middle Aged; Prednisone; Psoriasis; Receptors, Tumor Necrosis Factor; Skin; Tumor Necrosis Factor-alpha | 2008 |
Comparative effectiveness of tumour necrosis factor alpha inhibitors in combination with either methotrexate or leflunomide.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
Expression of multidrug resistance-1 protein correlates with disease activity rather than the refractoriness to methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Female; Follow-Up Studies; Gene Expression Regulation; Humans; Immunosuppressive Agents; Lymphocytes; Male; Methotrexate; Middle Aged; Treatment Outcome | 2009 |
Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Cohort Studies; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult | 2010 |
TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cytokine TWEAK; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Synovial Membrane; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; TWEAK Receptor; Young Adult | 2010 |
[Paradigm shift in the therapy for rheumatoid arthritis and osteoporosis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density Conservation Agents; Diphosphonates; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Osteoporosis; Practice Guidelines as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Adding low dose tacrolimus in rheumatoid arthritis patients with an inadequate response to tumor necrosis factor inhibitor therapies.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Tacrolimus; Tumor Necrosis Factor-alpha | 2009 |
[Leflunomide in combination with TNF-blockers for Methotrexate intolerance].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor Inhibitors | 2009 |
Racial disparities in treatment preferences for rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Black or African American; Communication; Decision Making; District of Columbia; Female; Health Knowledge, Attitudes, Practice; Healthcare Disparities; Humans; Interviews as Topic; Male; Medication Adherence; Methotrexate; Middle Aged; Outpatient Clinics, Hospital; Patient Satisfaction; Psychometrics; Rheumatology; Socioeconomic Factors; Software; Tumor Necrosis Factor-alpha; Virginia; White People; Young Adult | 2009 |
Disease-modifying antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2009 |
Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Chi-Square Distribution; Cross-Sectional Studies; Female; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide; Prospective Studies; Treatment Outcome | 2009 |
Marked regression of pulmonary rheumatoid nodules under etanercept therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Administration Schedule; Etanercept; Female; Humans; Immunoglobulin G; Lung; Methotrexate; Middle Aged; Multiple Pulmonary Nodules; Receptors, Tumor Necrosis Factor; Tomography, X-Ray Computed; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Infectious complications in patients with psoriasis and rheumatoid arthritis treated with antitumor necrosis factor agents and methotrexate.
Topics: Arthritis, Rheumatoid; Bacterial Infections; Drug Therapy, Combination; Epidural Abscess; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Psoriasis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
Contemporary use of disease-modifying drugs in the management of patients with early rheumatoid arthritis in Norway.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Diagnosis; Female; Follow-Up Studies; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Norway; Odds Ratio; Pain Measurement; Probability; Risk Assessment; Sex Factors; Sulfasalazine; Treatment Outcome | 2009 |
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biopsy; Case-Control Studies; Drug Resistance, Multiple; Endothelial Cells; Humans; Isoxazoles; Leflunomide; Macrophages; Methotrexate; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Synovial Membrane | 2009 |
[What's new in internal medicine?].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteriophages; Body Mass Index; Diabetes Complications; Drug Therapy, Combination; Humans; Hydroxychloroquine; Hypereosinophilic Syndrome; Hypertension; Immunosuppressive Agents; Internal Medicine; Methotrexate; Mimiviridae; Obesity; Risk Factors; Treatment Outcome; Venous Thromboembolism | 2008 |
[Cutaneous leishmaniasis in rheumatoid arthritis].
Topics: Adult; Antiprotozoal Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunocompromised Host; Immunosuppressive Agents; Leishmaniasis, Cutaneous; Meglumine; Meglumine Antimoniate; Methotrexate; Middle Aged; Organometallic Compounds; Prednisone | 2009 |
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Asian People; Female; Fractures, Bone; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Spinal Fractures | 2009 |
Choice of second-line disease-modifying antirheumatic drugs after failure of methotrexate therapy for rheumatoid arthritis: a decision tree for clinical practice based on rheumatologists' preferences.
Topics: Antibodies, Anti-Idiotypic; Antirheumatic Agents; Arthritis, Rheumatoid; Data Collection; Decision Trees; Humans; Interleukin 1 Receptor Antagonist Protein; Logistic Models; Methotrexate; Peptides, Cyclic; Practice Patterns, Physicians'; Rheumatoid Factor; Severity of Illness Index; Treatment Failure; Tumor Necrosis Factor-alpha | 2009 |
[Therapy of rheumatoid arthritis with etanercept].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome | 2009 |
Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Infections; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prednisone; Tumor Necrosis Factor-alpha; United States | 2010 |
Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false-positive report probability.
Topics: Arthritis, Rheumatoid; Drug Resistance; False Positive Reactions; Genotype; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Multienzyme Complexes; Nucleotide Deaminases; Pharmacogenetics; Probability | 2009 |
A new low-field extremity magnetic resonance imaging and proposed compact MRI score: evaluation of anti-tumor necrosis factor biologics on rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Finger Joint; Humans; Immunoglobulin G; Infliximab; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisolone; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Synovitis; Treatment Outcome; Wrist Joint | 2009 |
Interstitial pneumonitis associated with infliximab therapy without methotrexate treatment.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Female; Humans; Infliximab; Lung Diseases, Interstitial; Methotrexate; Methylprednisolone; Mucin-1; Radiography; Severity of Illness Index; Treatment Outcome | 2009 |
In-office magnetic resonance imaging to monitor responses to therapy in rheumatoid arthritis.
Topics: Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Monitoring, Physiologic; Prednisone; Rituximab; Synovitis | 2009 |
Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Gastrointestinal Diseases; Hospitals, Teaching; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Liver; Male; Methotrexate; Middle Aged; New South Wales; Practice Guidelines as Topic; Remission Induction; Retrospective Studies; Rheumatology; Young Adult | 2009 |
Abatacept: new drug. Rheumatoid arthritis: after failure of TNF alpha antagonists and rituximab.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Europe; Humans; Immunoconjugates; Immunosuppressive Agents; Methotrexate; Tumor Necrosis Factor-alpha | 2008 |
Salazosulfapyridine-induced hypersensitivity syndrome triggered by methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Sulfasalazine | 2009 |
[How effective is rituximab in rheumatoid arthritis?: lessons learned from clinical practice].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome | 2010 |
The effect of infliximab on antiviral antibody profiles in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Immunity, Humoral; Immunosuppression Therapy; Infliximab; Male; Measles; Methotrexate; Middle Aged; Poliomyelitis; Prednisone; Prospective Studies; Rubella; Virus Diseases; Viruses | 2010 |
Tight control is important in patients with rheumatoid arthritis treated with an anti-tumor necrosis factor biological agent: prospective study of 91 cases who used a biological agent for more than 1 year.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Joints; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Risk Factors; Severity of Illness Index; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
Effect of methotrexate and anti-TNF on Epstein-Barr virus T-cell response and viral load in patients with rheumatoid arthritis or spondylarthropathies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Herpesvirus 4, Human; Humans; Longitudinal Studies; Methotrexate; Middle Aged; Spondylarthropathies; T-Lymphocytes; Tumor Necrosis Factor-alpha; Viral Load | 2009 |
Facilitating the use of COBRA combination therapy in early rheumatoid arthritis: a pilot implementation study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Generic; Female; Health Plan Implementation; Humans; Male; Methotrexate; Middle Aged; Patient Education as Topic; Patient Satisfaction; Pilot Projects; Prednisolone; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2009 |
Normolipemic plane xanthomatosis with acute development preceding the clinical onset of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Eyelid Diseases; Female; Humans; Methotrexate; Middle Aged; Xanthomatosis | 2009 |
Does TNF-alpha blockade play any role in cardiovascular risk among rheumatoid arthritis (RA) patients?
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Insulin Resistance; Interferon-gamma; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2009 |
Methotrexate: the gold standard without standardisation.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2009 |
Leflunomide-induced polymyositis in a patient with rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Alanine Transaminase; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Muscle, Skeletal; Polymyositis; Prednisolone; Treatment Outcome | 2009 |
A followup study of asymptomatic carriers of Pneumocystis jiroveci during immunosuppressive therapy for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Carrier State; Female; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumocystis Infections; Polymerase Chain Reaction; Sputum | 2009 |
Methotrexate-related lymphoproliferative disorder with extensive vascular involvement in a patient with rheumatoid arthritis.
Topics: Aged, 80 and over; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Skin Diseases | 2009 |
RA treatment study group: improvement in RA management.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunologic Factors; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Lymphomatoid granulomatosis in a patient with rheumatoid arthritis receiving methotrexate: successful treatment with the anti-CD20 antibody mabthera.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphomatoid Granulomatosis; Methotrexate; Rituximab; Treatment Outcome | 2009 |
Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Cell Proliferation; Humans; Lymphocyte Activation; Methotrexate; Pneumonia; Reproducibility of Results; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Treatment of rheumatoid arthritis: we are getting there.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Humans; Methotrexate; Patient Selection; Radiography; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Methotrexate: still the anchor drug in RA treatment.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Monitoring; Evidence-Based Medicine; Fatigue; Humans; Methotrexate; Netherlands; Tumor Necrosis Factor-alpha | 2009 |
Disease remission state in patients treated with the combination of tumor necrosis factor blockade and methotrexate or with disease-modifying antirheumatic drugs: A clinical and imaging comparative study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Remission Induction; Synovitis; Treatment Outcome; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler; Wrist Joint | 2009 |
An excellent example of an early arthritis clinic -- what is its clinical value?
Topics: Ambulatory Care Facilities; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cost-Benefit Analysis; Humans; Methotrexate; Treatment Outcome | 2009 |
Preliminary study to identify the predictive factors for the response to methotrexate therapy in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cohort Studies; Erythrocytes; Female; Forecasting; Genotype; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Polymorphism, Genetic; Tetrahydrofolates; Thymidylate Synthase | 2009 |
Hepatotoxicity rates do not differ in patients with rheumatoid arthritis and psoriasis treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors | 2009 |
Therapeutic and preventive effects of methotrexate on zymosan-induced arthritis in SKG mice.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Female; Immunohistochemistry; Methotrexate; Mice; Mice, Inbred BALB C; Random Allocation | 2009 |
Prevalence of positive ppd in a cohort of rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Biological Products; Cross-Sectional Studies; Female; Humans; Isoxazoles; Latent Tuberculosis; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Risk Assessment; Risk Factors; Steroids; Treatment Outcome; Tuberculin Test; Tumor Necrosis Factor-alpha | 2010 |
Prediction of DAS28-ESR remission at 6 months by baseline variables in patients with rheumatoid arthritis treated with etanercept in Japanese population.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Japan; Male; Methotrexate; Middle Aged; Patient Compliance; Predictive Value of Tests; Receptors, Tumor Necrosis Factor; Regression Analysis; Remission Induction; Severity of Illness Index; Sex Factors; Treatment Outcome | 2009 |
Potential effects of a national consensus statement on optimal treatment of early rheumatoid arthritis in Ontario.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Consensus Development Conferences as Topic; Humans; Methotrexate; Ontario | 2009 |
The efficacy of disease modifying anti-rheumatic drugs in rheumatoid arthritis in local patients of Karachi.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Pakistan; Retrospective Studies; Treatment Outcome | 2009 |
Rituximab therapy in patients with rheumatoid arthritis refractory or with contraindication to anti-tumour necrosis factor drugs: real-life experience in Finnish patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Contraindications; Drug Therapy, Combination; Female; Finland; Humans; Male; Medical Records; Methotrexate; Middle Aged; Pain; Pain Measurement; Prednisolone; Retrospective Studies; Rituximab; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2009 |
Golimumab (simponi) for inflammatory arthritis.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Injections, Subcutaneous; Methotrexate; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis ameliorated by folate supplement.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Gynecomastia; Humans; Male; Mammography; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome; Vitamin B Complex | 2010 |
Comment on: Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Polymorphism, Single Nucleotide; Research Design | 2009 |
Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Chi-Square Distribution; Disease Progression; Drug Therapy, Combination; Female; Finger Joint; Humans; Isoxazoles; Japan; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies; Severity of Illness Index; Statistics, Nonparametric; Toe Joint; Treatment Outcome; Wrist Joint | 2009 |
Optimalization of the clinical pharmacogenetic model to predict methotrexate treatment response: the influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Haplotypes; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Models, Genetic; Polymorphism, Single Nucleotide; Prognosis; Treatment Outcome | 2009 |
Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Prevalence | 2009 |
Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2009 |
Methotrexate-associated lymphoproliferative disorders mimicking angioimmunoblastic T-cell lymphoma.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Diagnosis, Differential; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunoblastic Lymphadenopathy; Lymphoma, T-Cell; Lymphoproliferative Disorders; Male; Methotrexate | 2010 |
Retention rates of disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Disability Evaluation; Female; Humans; Male; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2009 |
Determinants of red blood cell methotrexate polyglutamate concentrations in rheumatoid arthritis patients receiving long-term methotrexate treatment.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Smoking; Young Adult | 2009 |
Anti-adalimumab antibodies in rheumatoid arthritis patients are associated with interleukin-10 gene polymorphisms.
Topics: Adalimumab; Antibodies; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Haplotypes; Humans; Interleukin-10; Methotrexate; Polymorphism, Single Nucleotide; Prospective Studies | 2009 |
Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation.
Topics: Aldehyde Oxidase; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Folic Acid; Health Status; Humans; Joints; Leucovorin; Methotrexate; Pain; Tandem Mass Spectrometry; Treatment Outcome | 2009 |
Erythrocyte methotrexate-polyglutamate assay using fluorescence polarization immunoassay technique: application to the monitoring of patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Erythrocytes; Female; Fluorescence Polarization Immunoassay; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Sensitivity and Specificity | 2009 |
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dental Plaque Index; Female; Gingival Crevicular Fluid; Gingivitis; Glucocorticoids; Humans; Immunologic Factors; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 8; Methotrexate; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Periodontium; Prednisolone; Rheumatoid Factor; Tissue Inhibitor of Metalloproteinase-1 | 2009 |
Missing the obvious.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Etanercept; Humans; Immunoglobulin G; Methotrexate; Multiple Pulmonary Nodules; Receptors, Tumor Necrosis Factor | 2009 |
Plasma adiponectin in patients with active, early, and chronic rheumatoid arthritis who are steroid- and disease-modifying antirheumatic drug-naive compared with patients with osteoarthritis and controls.
Topics: Adiponectin; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Denmark; Dose-Response Relationship, Drug; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Osteoarthritis; Severity of Illness Index; Steroids; Young Adult | 2009 |
Infliximab treatment reduces the serum levels of interleukin-23 in patients with rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infliximab; Interleukin-17; Interleukin-23; Male; Methotrexate; Middle Aged; Prednisolone; Regression Analysis; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2009 |
Golimumab.
Topics: Antibodies, Monoclonal; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Spondylitis, Ankylosing; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factors | 2009 |
Recommendations for the therapeutics of methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Immunosuppressive Agents; Liver; Methotrexate; Perioperative Care | 2009 |
Images in clinical medicine. Baker's cyst in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Popliteal Cyst; Prednisone | 2009 |
Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoproliferative Disorders; Methotrexate; Stomach Neoplasms; Treatment Outcome | 2009 |
Disseminated varicella zoster infection in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Opportunistic Infections | 2009 |
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles | 2009 |
[Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with the focus on rheumatoid arthritis. Integration of a systematic literature research with the expert opinion of a large international panel of rheumatologi
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Dose-Response Relationship, Drug; Evidence-Based Medicine; Female; Humans; Immunosuppressive Agents; Infant, Newborn; Methotrexate; Pregnancy; Risk Factors | 2010 |
[Health-economic assessment of combination therapy for rheumatoid arthritis with methotrexat and etanercept based on the TEMPO Study].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Etanercept; Germany; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Monte Carlo Method; National Health Programs; Outcome Assessment, Health Care; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor | 2009 |
Acute respiratory distress syndrome associated with rapid aggravation of rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Methotrexate; Methylprednisolone; Pleural Effusion; Pulse Therapy, Drug; Radiography, Thoracic; Respiratory Distress Syndrome; Tomography, X-Ray Computed; Treatment Outcome | 2010 |
[Correct use of methotrexate].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Psoriasis; Treatment Outcome | 2009 |
[Methotrexate: safe if prescribed correctly].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Medication Errors; Methotrexate; Psoriasis | 2009 |
[Methotrexate: mainstay of rheumatoid arthritis treatment].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Methotrexate; Treatment Outcome | 2009 |
Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Chi-Square Distribution; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisolone; Regression Analysis; Remission Induction; Severity of Illness Index; Sex Factors; Statistics, Nonparametric; Tacrolimus; Treatment Outcome | 2009 |
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cyclic AMP; Female; GTP-Binding Proteins; Humans; Infliximab; Lymphocytes; Male; Methotrexate; Middle Aged; Neutrophils; NF-kappa B; Receptor, Adenosine A2A; Receptor, Adenosine A3; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Apolipoprotein A-I; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Female; Haptoglobins; Hemoglobins; Hemopexin; Humans; Lipoproteins, HDL; Male; Methotrexate; Middle Aged; Peroxidase; Phosphatidylcholine-Sterol O-Acyltransferase; Severity of Illness Index | 2009 |
Use of methotrexate therapy is not associated with decreased prevalence of metabolic syndrome.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Metabolic Syndrome; Methotrexate; Prevalence | 2009 |
Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Erythrocyte Volume; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Prospective Studies; Retrospective Studies; Time Factors; Young Adult | 2010 |
Compliance with methotrexate treatment in patients with rheumatoid arthritis: influence of patients' beliefs about the medicine. A prospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Culture; Female; Humans; Male; Methotrexate; Middle Aged; Patient Compliance; Prospective Studies | 2010 |
Scoring evaluation for histopathological features of synovium in patients with rheumatoid arthritis during anti-tumor necrosis factor therapy.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Biomarkers; Biopsy; C-Reactive Protein; Cell Proliferation; Chemotaxis, Leukocyte; Female; Glucocorticoids; Humans; Hyperplasia; Infliximab; Knee Joint; Lymphocyte Activation; Lymphocytes; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Neovascularization, Pathologic; Outcome Assessment, Health Care; Synovial Membrane; Tumor Necrosis Factor-alpha | 2010 |
Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; C-Reactive Protein; Female; gamma-Glutamyl Hydrolase; Humans; Japan; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Reduced Folate Carrier Protein | 2009 |
Comment on: Methotrexate pharmacogenomics in rheumatoid arthritis: introducing false positive report probability.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; False Positive Reactions; Humans; Methotrexate; Pharmacogenetics | 2009 |
[Methotrexate in rheumatology].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Methotrexate; Practice Patterns, Physicians'; Rheumatology | 2009 |
The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Forkhead Transcription Factors; Gene Expression; Humans; Interleukin-17; Interleukin-6; Male; Methotrexate; Middle Aged; Nuclear Receptor Subfamily 1, Group F, Member 3; RNA, Messenger; Th17 Cells; Treatment Outcome | 2010 |
Anaplastic large cell lymphoma in a patient with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Humans; Lymphoma, Large-Cell, Anaplastic; Male; Methotrexate | 2011 |
Improving pregnancy counseling for women with rheumatoid arthritis taking methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Counseling; Drug Administration Schedule; Female; Humans; Infant, Newborn; Methotrexate; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2009 |
Hepatoprotective effect of tumour necrosis factor alpha blockade in psoriatic arthritis: a cross-sectional study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cross-Sectional Studies; Drug Evaluation; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prospective Studies; Tumor Necrosis Factor-alpha | 2010 |
Rheumatoid arthritis in patient with homozygous haemoglobin C disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Hemoglobin C Disease; Homozygote; Humans; Methotrexate; Middle Aged; Osteoporosis; Prednisone; Remission Induction | 2011 |
Comment on: Hepatotoxicity rates do not differ in patients with rheumatoid arthritis and psoriasis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Methotrexate; Research Design | 2010 |
Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.
Topics: Adenosine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biosynthetic Pathways; Epistasis, Genetic; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2009 |
QuantiFERON-TB Gold in the identification of latent tuberculosis infection in rheumatoid arthritis: a pilot study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma; Latent Tuberculosis; Male; Methotrexate; Middle Aged; Mycobacterium; Pilot Projects; Predictive Value of Tests; Prednisone; Radiography; Reagent Kits, Diagnostic; Surveys and Questionnaires; Tuberculin Test | 2009 |
Nontuberculous mycobacteria infection and tumor necrosis factor-alpha antagonists.
Topics: Adalimumab; Aged; Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Mycobacterium haemophilum; Mycobacterium Infections; Tumor Necrosis Factor-alpha | 2009 |
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Etanercept; Female; Humans; Immunoglobulin G; Incidence; Infliximab; Male; Methotrexate; Middle Aged; Neoplasms; Receptors, Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Factors; Sweden; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Interpreting registry-derived drug studies: does societal context matter?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Hematologic Neoplasms; Humans; Methotrexate; Registries; Risk Factors; Severity of Illness Index; Single-Payer System; Skin Neoplasms; Socioeconomic Factors; Sweden; Tumor Necrosis Factor-alpha; United States | 2009 |
Tocilizumab: new drug. Rheumatoid arthritis: another 'mab', no therapeutic advantage.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Europe; Humans; Immunologic Factors; Immunosuppressive Agents; Interleukin-6; Methotrexate; Randomized Controlled Trials as Topic; Rituximab | 2009 |
Treatment of very early rheumatoid arthritis with symptomatic therapy, disease-modifying antirheumatic drugs, or biologic agents: a cost-effectiveness analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Support Techniques; Disease Progression; Glucocorticoids; Health Care Costs; Humans; Immunologic Factors; Methotrexate; Quality-Adjusted Life Years; Radiography; Treatment Outcome | 2009 |
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians.
Topics: AMP Deaminase; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Hydroxymethyl and Formyl Transferases; India; Logistic Models; Male; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Purines | 2009 |
Association of mean platelet volume with hypertension in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Platelets; Blood Pressure; Cardiovascular Diseases; Cell Size; Cohort Studies; Female; Humans; Hypertension; Male; Methotrexate; Middle Aged; Platelet Count; Risk Factors | 2010 |
Initiation of rheumatoid arthritis treatments and the risk of serious infections.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Glucocorticoids; Hospitalization; Humans; Immunosuppressive Agents; Methotrexate; Opportunistic Infections; Pneumonia; Risk Assessment; Tennessee; Tumor Necrosis Factor-alpha | 2010 |
Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis.
Topics: Adult; Amenorrhea; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate | 2010 |
[Cutaneous infection due to Mycobacterium chelonae during anti-TNF therapy].
Topics: Adalimumab; Aged; Amoxicillin-Potassium Clavulanate Combination; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biopsy; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Prednisone; Receptors, Tumor Necrosis Factor; Skin; Tumor Necrosis Factor-alpha | 2009 |
[Security of the combined treatment of methotrexate and leflunomide in patients with rheumatoid arthritis].
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Injections, Intramuscular; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2007 |
Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Idiopathic Pulmonary Fibrosis; Kaplan-Meier Estimate; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisone; Prognosis; Retrospective Studies; Tomography, X-Ray Computed | 2010 |
A more active treatment has profound effects on the health status of rheumatoid arthritis (RA) patients: results from a population-based RA register in Malmö, Sweden, 1997-2005.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Disease Progression; Female; Glucocorticoids; Health Status; Health Surveys; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Registries; Severity of Illness Index; Surveys and Questionnaires; Sweden; Treatment Outcome | 2010 |
A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis.
Topics: Absorptiometry, Photon; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Diphosphonates; Drug Therapy, Combination; Female; Imidazoles; Immunohistochemistry; Methotrexate; Osteoclasts; Rats; Rats, Sprague-Dawley; Tomography, X-Ray Computed; Zoledronic Acid | 2009 |
A new design for registration trials in rheumatoid arthritis allowing secondary head-to-head comparisons with standard of care treatment including biologicals.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunologic Factors; Methotrexate; Randomized Controlled Trials as Topic; Research Design; Time Factors; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
[Effect of increasing the infliximab dose in rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Randomized Controlled Trials as Topic | 2010 |
CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD11c Antigen; Cohort Studies; Female; Genetic Markers; Humans; Male; Methotrexate; Middle Aged; Monocytes; Predictive Value of Tests; Protein Array Analysis; Transcription, Genetic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibodies, Viral; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocyte Subsets; Drug Therapy, Combination; Female; Hemagglutination Inhibition Tests; Humans; Immunity, Humoral; Immunization Schedule; Immunologic Memory; Influenza Vaccines; Male; Methotrexate; Middle Aged; Rituximab; Vaccines, Inactivated | 2010 |
Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy.
Topics: Aged; Antibodies, Monoclonal; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Count; Cell Differentiation; Cell Proliferation; Dendritic Cells; Female; Flow Cytometry; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infliximab; Interleukin-10; Male; Methotrexate; Middle Aged; Plasma Cells; T-Lymphocytes, Regulatory | 2010 |
My doctor recommended I take methotrexate to relieve the pain of the rheumatoid arthritis I have in my shoulder. But I've heard that methotrexate can cause liver problems. How will I know if I'm developing liver problems?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Liver; Liver Diseases; Methotrexate; Risk Factors; Shoulder Pain | 2009 |
Clinical improvement in rheumatoid arthritis is associated with healthier microvascular function in patients who respond to antirheumatic therapy.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dose-Response Relationship, Drug; Endothelium, Vascular; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Male; Methotrexate; Microcirculation; Middle Aged; Receptors, Tumor Necrosis Factor; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Methotrexate compliance among patients with rheumatoid arthritis: the influence of disease activity, disease duration, and co-morbidity in a 10-year longitudinal study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Longitudinal Studies; Male; Medication Adherence; Methotrexate; Middle Aged; Patient Selection; Regression Analysis; Severity of Illness Index; Surveys and Questionnaires; Time Factors | 2010 |
Increased expression of proto-oncogene survivin predicts Joint destruction and persistent disease activity in early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Inhibitor of Apoptosis Proteins; Male; Methotrexate; Microtubule-Associated Proteins; Middle Aged; Peptides, Cyclic; Prospective Studies; Proto-Oncogene Mas; Radiography; Rheumatoid Factor; Sulfasalazine; Survivin; Treatment Outcome | 2010 |
Composite cutaneous lymphoma in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; DNA, Neoplasm; Female; Gene Rearrangement, B-Lymphocyte; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Gene Rearrangement, T-Lymphocyte; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell, Cutaneous; Methotrexate; Neoplasms, Multiple Primary; Skin Neoplasms | 2010 |
Do snapshot statistics fool us in MTX pharmacogenetic studies in arthritis research?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; False Positive Reactions; Humans; Meta-Analysis as Topic; Methotrexate; Pharmacogenetics; Research Design; Statistics as Topic; Time Factors | 2010 |
Mycobacterial hand infections occurring postoperatively in patients treated with tumor necrosis factor-alpha inhibitors for inflammatory arthritis: report of three cases.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Azithromycin; Etanercept; Female; Hand; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Mycobacterium Infections; Receptors, Tumor Necrosis Factor; Tenosynovitis; Trimethoprim, Sulfamethoxazole Drug Combination; Tumor Necrosis Factor-alpha | 2010 |
Time to methotrexate treatment in patients with rheumatoid arthritis referred to hospital.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cohort Studies; Confidence Intervals; Denmark; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Inflammation Mediators; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Odds Ratio; Outpatient Clinics, Hospital; Probability; Proportional Hazards Models; Referral and Consultation; Retrospective Studies; Rheumatology; Risk Assessment; Severity of Illness Index; Sex Factors; Treatment Outcome; Young Adult | 2010 |
Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis.
Topics: Age of Onset; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Data Interpretation, Statistical; Disease Progression; DNA; Endpoint Determination; Genotype; Humans; Methotrexate; Odds Ratio; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide | 2010 |
Methotrexate treatment in rheumatoid arthritis: management in clinical remission, common infection and tuberculosis. Results from a systematic literature review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Evidence-Based Medicine; Humans; Infections; Methotrexate; Tuberculosis | 2010 |
Patient-derived joint counts are a potential alternative for determining Disease Activity Score.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Etanercept; Female; Health Status; Humans; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Patient Participation; Patient Satisfaction; Physical Examination; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Synovitis; Treatment Outcome | 2010 |
Is a 12-week trial sufficient to evaluate clinical responses to etanercept or MTX treatment in early RA?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Progression; Humans; Methotrexate; Middle Aged; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission.
Topics: Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Episode of Care; Female; Glucocorticoids; Hospitalization; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Patient Compliance; Product Surveillance, Postmarketing; Retrospective Studies; Tennessee | 2010 |
Rheumatoid arthritis is an independent risk factor for increased carotid intima-media thickness: impact of anti-inflammatory treatment.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carotid Artery Diseases; Case-Control Studies; Female; Humans; Methotrexate; Middle Aged; Regression Analysis; Risk Factors; Time Factors; Tunica Intima; Tunica Media; Ultrasonography; Young Adult | 2010 |
Clinicopathologic correlations of diffuse large B-cell lymphoma in rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; RNA, Viral; Translocation, Genetic | 2010 |
Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Comorbidity; Female; Humans; Incidence; Infliximab; Japan; Logistic Models; Lung Diseases, Interstitial; Male; Methotrexate; Pain Measurement; Risk Factors; Severity of Illness Index; Sex Factors; Surveys and Questionnaires | 2010 |
Effect of light emitting diodes in the photodynamic therapy of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Equipment Design; Equipment Failure Analysis; Humans; Lighting; Lymphocytes; Methotrexate; Photochemotherapy; Photosensitizing Agents; Semiconductors | 2010 |
[Immunosuppressive therapy and tuberculosis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Interferon-gamma; Isoniazid; Japan; Methotrexate; Sensitivity and Specificity; Tuberculosis; Tumor Necrosis Factor-alpha | 2010 |
Effects of long-term disease-modifying antirheumatic drugs on endothelial function in patients with early rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Carotid Artery, Common; Case-Control Studies; Coronary Circulation; Coronary Vessels; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Italy; Male; Methotrexate; Microcirculation; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2010 |
[Renal leiomyosarcoma, rheumatoid arthritis and methotrexate].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Leiomyosarcoma; Methotrexate; Renal Veins; Vascular Neoplasms | 2010 |
Therapeutic efficacy of experimental rheumatoid arthritis with low-dose methotrexate by increasing partially CD4+CD25+ Treg cells and inducing Th1 to Th2 shift in both cells and cytokines.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; CD4 Lymphocyte Count; Collagen Type II; Cytokines; Female; Immune Tolerance; Lymphocyte Activation; Methotrexate; Rats; Rats, Wistar; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells | 2010 |
Health-related quality of life and disability in patients with rheumatoid, early rheumatoid and early psoriatic arthritis treated with etanercept.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Case-Control Studies; Disability Evaluation; Etanercept; Female; Follow-Up Studies; Health Status; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Pain Measurement; Prospective Studies; Quality of Life; Receptors, Tumor Necrosis Factor; Sickness Impact Profile; Surveys and Questionnaires; Treatment Outcome | 2010 |
Histological analysis of synovium by treatment of etanercept for rheumatoid arthritis.
Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Etanercept; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoglobulin G; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Synovial Membrane; Tumor Necrosis Factor-alpha | 2009 |
Precore mutant hepatitis B virus-associated fulminant hepatitis during infliximab therapy for rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; DNA, Viral; Drug Therapy, Combination; Fatal Outcome; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Mutation; Withholding Treatment | 2013 |
Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis.
Topics: Aged; Alleles; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Epitopes; Female; Gene Frequency; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate.
Topics: AMP Deaminase; Arthritis, Rheumatoid; Erythrocytes; Ferredoxin-NADP Reductase; Folic Acid; Genome-Wide Association Study; Glycine Hydroxymethyltransferase; Humans; Longitudinal Studies; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Polyglutamic Acid; Polymorphism, Genetic | 2010 |
Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Methotrexate | 2012 |
[A cutaneous infection by Mycobacterium chelonae in a patient with rheumatoid arthritis].
Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Ciprofloxacin; Clarithromycin; Drug Combinations; Female; Glucosamine; Humans; Immunosuppressive Agents; Leg; Methotrexate; Middle Aged; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Sulfasalazine; Tuberculosis, Cutaneous | 2010 |
Genetic determinants of methotrexate treatment in rheumatoid arthritis patients: a study of polymorphisms in the adenosine pathway.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Severity of Illness Index; Treatment Outcome | 2010 |
Patients with RA in remission on TNF blockers: when and in whom can TNF blocker therapy be stopped?
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunophenotyping; Male; Methotrexate; Middle Aged; Remission Induction; Synovitis; T-Lymphocytes, Regulatory; Treatment Outcome; Tumor Necrosis Factor-alpha; Ultrasonography; Young Adult | 2010 |
CD8(+) T-cell lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis during methotrexate therapy.
Topics: Acyclovir; Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Female; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunophenotyping; Lymph Nodes; Lymphoproliferative Disorders; Meningoencephalitis; Methotrexate; Methylprednisolone | 2010 |
Race and methotrexate pharmacogenetics in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Racial Groups | 2010 |
A case of normal-pressure hydrocephalus associated with rheumatoid arthritis.
Topics: Activities of Daily Living; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Cognition Disorders; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Methotrexate; Prednisone; Treatment Outcome | 2010 |
Profound invariant natural killer T-cell deficiency in inflammatory arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; C-Reactive Protein; Cell Proliferation; Cells, Cultured; Diagnosis, Differential; Female; Galactosylceramides; Humans; Immunosuppressive Agents; Lymphocyte Count; Male; Methotrexate; Middle Aged; Natural Killer T-Cells; Osteoarthritis; Young Adult | 2010 |
Risk of elevated liver enzymes associated with TNF inhibitor utilisation in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Alanine Transaminase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Liver Function Tests; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2010 |
Sicca symptoms, and lacrimal and salivary flow in Albanian patients with rheumatoid arthritis.
Topics: Adult; Aged; Albania; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Female; Gastrointestinal Diseases; Glucocorticoids; Humans; Keratoconjunctivitis Sicca; Male; Methotrexate; Methylprednisolone; Middle Aged; Saliva; Secretory Rate; Sjogren's Syndrome; Surveys and Questionnaires; Tears; Time Factors; Xerostomia | 2010 |
Decrease in the levels of anti-cyclic citrullinated peptide antibody in Japanese patients with rheumatoid arthritis who responded to anti-tumor necrosis factor-α.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Etanercept; Health Status; Humans; Immunoglobulin G; Immunoglobulin M; Methotrexate; Middle Aged; Peptides, Cyclic; Receptors, Tumor Necrosis Factor; Rituximab; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2010 |
Seven-year follow-up of infliximab therapy in rheumatoid arthritis patients with severe long-standing refractory disease: attrition rate and evolution of disease activity.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Belgium; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Health Surveys; Humans; Infliximab; Infusions, Intravenous; Kaplan-Meier Estimate; Longitudinal Studies; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2010 |
Cytomegalovirus-induced infectious mononucleosis-like syndrome in a rheumatoid arthritis patient treated with methotrexate and infliximab.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cytomegalovirus; Cytomegalovirus Infections; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Infectious Mononucleosis; Infliximab; Methotrexate; Tumor Necrosis Factor-alpha | 2010 |
Assessment of liver fibrosis by transient elastography in rheumatoid arthritis patients treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Chemical Analysis; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Female; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Prospective Studies | 2010 |
A 78-joints ultrasonographic assessment is associated with clinical assessments and is highly responsive to improvement in a longitudinal study of patients with rheumatoid arthritis starting adalimumab treatment.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prednisolone; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler; Young Adult | 2010 |
Antibodies against cyclic citrullinated peptide don't decrease after 6 months of infliximab treatment in refractory rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunoglobulin M; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Young Adult | 2011 |
Arthritis mutilans in a patient with systemic lupus erythematosus and rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Comorbidity; Female; Humans; Lupus Erythematosus, Systemic; Methotrexate; Osteolysis; Treatment Outcome | 2010 |
Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Joints; Leukocytes, Mononuclear; Logistic Models; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Pain; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; ROC Curve; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Leflunomide in combination therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infections; Isoxazoles; Leflunomide; Methotrexate; New Zealand; Pancytopenia; Pneumonia | 2010 |
Methotrexate polyglutamate concentrations and association with disease control in rheumatoid arthritis: comment on the article by Stamp et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Polyglutamic Acid; Treatment Outcome | 2010 |
Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Chi-Square Distribution; Gene Frequency; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Odds Ratio; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Precision Medicine; Risk Assessment; Risk Factors; Transaminases; Treatment Outcome; Up-Regulation | 2011 |
[Reactivation of tuberculosis with Mycobacterium bovis infection of the oral mucosa during immunosuppression].
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Methotrexate; Mouth Mucosa; Mycobacterium bovis; Opportunistic Infections; Recurrence; Tuberculosis, Oral | 2010 |
Improvement of work ability, quality of life, and fatigue in patients with rheumatoid arthritis treated with adalimumab.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Efficiency; Fatigue; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Tumor Necrosis Factor Inhibitors | 2010 |
Borreliosis in a patient treated with anti-TNFα therapy: first case.
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Doxycycline; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Lyme Disease; Methotrexate; Middle Aged; Opportunistic Infections; Prednisone; Receptors, Tumor Necrosis Factor; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Miliary tuberculosis and necrotizing tuberculous fasciitis--an unusual coexistence in a rheumatoid arthritis patient.
Topics: Aged; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Fasciitis, Necrotizing; Humans; Immunocompromised Host; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Mycobacterium tuberculosis; Tuberculosis, Miliary; Tuberculosis, Pulmonary | 2010 |
A case of emphysematous pyelonephritis in a patient with rheumatoid arthritis taking corticosteroid and low-dose methotrexate.
Topics: Aged; Amyloidosis; Arthritis, Rheumatoid; Diabetes Mellitus; Dose-Response Relationship, Drug; Emphysema; Female; Glucocorticoids; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Pyelonephritis; Serum Amyloid A Protein | 2010 |
When should we use parenteral methotrexate?
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Drug Administration Schedule; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Treatment Outcome | 2010 |
Adenosine 5'-triphosphate infusions reduced disease activity and inflammation in a patient with active rheumatoid arthritis.
Topics: Activities of Daily Living; Adenosine Monophosphate; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Severity of Illness Index; Thionucleotides; Treatment Outcome | 2010 |
Efficacy and safety of tacrolimus in 101 consecutive patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Health Status; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2010 |
Comparison between adalimumab, etanercept, and infliximab in rheumatoid arthritis: comment on the article by Hetland et al.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bias; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Longitudinal Studies; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2010 |
Rheumatoid arthritis and renal light-chain deposition disease: long-term effectiveness of TNF-α blockade with etanercept.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Immunoglobulin Light Chains; Methotrexate; Nephrotic Syndrome; Prednisone; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2011 |
74-week follow-up of safety of infliximab in patients with refractory rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Drug Therapy, Combination; Female; Follow-Up Studies; Health Surveys; Humans; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prevalence; Prospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
Elevated level of serum cystatin-C concentration is a useful predictor for myelosuppression induced by methotrexate for treatment of rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Diseases; Creatinine; Cystatin C; Female; Humans; Immunosuppressive Agents; Kidney Function Tests; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Renal Insufficiency | 2010 |
Organizing pneumonia in a patient with rheumatoid arthritis treated with etanercept.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cryptogenic Organizing Pneumonia; Cysteine; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Radiography, Thoracic; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2010 |
Methotrexate for rheumatoid arthritis: a guide from Canada.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Consensus Development Conferences as Topic; Guidelines as Topic; Methotrexate | 2010 |
Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?
Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2010 |
[Measurement of inflammatory cytokines in patients with rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Female; Humans; Interleukin-6; Methotrexate; Middle Aged; Rheumatoid Factor; Tumor Necrosis Factor-alpha | 2010 |
Current concepts in the genetic diagnostics of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Sulfasalazine | 2010 |
[Combined therapy in a patient with generalized aggressive periodontitis and rheumatoid arthritis: a 15-year follow up case].
Topics: Adult; Aggressive Periodontitis; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Dental Scaling; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Metronidazole; Periodontal Splints; Root Canal Therapy; Spiramycin | 2010 |
Serum cystatin C level in patients with rheumatoid arthritis after single infusion of infliximab.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cystatin C; Drug Therapy, Combination; Female; Humans; Infliximab; Methotrexate; Middle Aged; Postmenopause; Prednisone | 2011 |
Associations of disease activity and treatments with mortality in men with rheumatoid arthritis: results from the VARA registry.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Registries; Risk Factors; Severity of Illness Index; United States; Veterans | 2011 |
Ups and downs in the treatment strategies of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Glucocorticoids; Humans; Methotrexate; Treatment Outcome | 2011 |
Measurement of erythrocyte methotrexate polyglutamate levels: ready for clinical use in rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Erythrocytes; Humans; Methotrexate; Polyglutamic Acid; Treatment Outcome | 2010 |
Epstein-Barr virus-infected subcutaneous panniculitis-like T-cell lymphoma associated with methotrexate treatment.
Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Humans; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Panniculitis | 2010 |
Methotrexate-related Epstein-Barr Virus (EBV)-associated lymphoproliferative disorder--so-called "Hodgkin-like lesion"--of the oral cavity in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Lymphoproliferative Disorders; Methotrexate; Mouth; RNA, Viral | 2010 |
Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Statistics as Topic | 2010 |
Adverse effects of low dose methotrexate in rheumatoid arthritis patients. A hospital-based study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Hospitals; Humans; Male; Methotrexate; Retrospective Studies | 2010 |
Changes in glycosylated hemoglobin after initiation of hydroxychloroquine or methotrexate treatment in diabetes patients with rheumatic diseases.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Glucose; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Hydroxychloroquine; Insulin; Linear Models; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Retrospective Studies; Rheumatic Diseases; Treatment Outcome | 2010 |
A case of progressive multifocal leukoencephalopathy in a patient treated with infliximab.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Methotrexate; Nerve Fibers, Myelinated; Prednisone; Tumor Necrosis Factor-alpha | 2010 |
A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammatory disease patients screened for latent tuberculosis prior to the initiation of a first tumor necrosis factor α inhibitor.
Topics: Arthritis, Rheumatoid; Azathioprine; Biological Assay; CD4-Positive T-Lymphocytes; Female; Glucocorticoids; Humans; Immunity, Cellular; Interferon-gamma; Isoxazoles; Latent Tuberculosis; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Tuberculin Test; Tumor Necrosis Factor-alpha | 2011 |
Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Hepatitis A Virus Cellular Receptor 2; Humans; Leukocytes, Mononuclear; Lymphocytes; Male; Membrane Proteins; Methotrexate; Middle Aged; Monocytes; Natural Killer T-Cells; Severity of Illness Index; Tumor Necrosis Factor-alpha; Up-Regulation; Young Adult | 2010 |
[Arthritis of the atlanto-axial joint with inflammatory neck pain as a primary manifestation of seronegative rheumatoid arthritis].
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Atlanto-Axial Joint; Diagnosis, Differential; Female; Humans; Methotrexate; Neck Pain; Osteoarthritis; Prednisolone | 2010 |
Testing pharmacogenetic indices to predict efficacy and toxicity of methotrexate monotherapy in a rheumatoid arthritis patient cohort.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Genotype; Humans; Logistic Models; Methotrexate; Pharmacogenetics; Predictive Value of Tests; Treatment Outcome | 2010 |
Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report.
Topics: Aged; Albendazole; Animals; Antinematodal Agents; Arthritis, Rheumatoid; Asthma; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Intestinal Diseases, Parasitic; Ivermectin; Methotrexate; Opportunistic Infections; Pregnenediones; Soil; Strongyloides stercoralis; Strongyloidiasis | 2010 |
The association of common variable immune deficiency with idiopathic inflammatory myopathies.
Topics: Arthritis, Rheumatoid; Autoantibodies; Common Variable Immunodeficiency; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Ligases; Methotrexate; Methylprednisolone; Middle Aged; Polymyositis; Treatment Outcome | 2010 |
Malignancies in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autopsy; Biological Therapy; Breast Neoplasms; Case-Control Studies; Cause of Death; Comorbidity; Female; Finland; Humans; Lymphoma; Male; Methotrexate; Ovarian Neoplasms; Prevalence; Retrospective Studies | 2011 |
Oral tuberculosis in a patient with rheumatoid arthritis after long treatment with methotrexate and adalimumab.
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Immunosuppressive Agents; Male; Methotrexate; Palatine Tonsil; Tuberculosis, Oral | 2010 |
Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
Topics: Adult; Antibodies, Monoclonal; Arthritis, Rheumatoid; Combined Modality Therapy; Enzyme-Linked Immunosorbent Assay; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Registries; Severity of Illness Index; Smoking; Sweden; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Optimal treatment of rheumatoid arthritis: EULAR recommendations for clinical practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Delivery of Health Care; Drug Therapy, Combination; European Union; Evidence-Based Medicine; Guideline Adherence; Humans; Methotrexate; Poland; Practice Guidelines as Topic; Quality Assurance, Health Care; Rheumatology | 2010 |
Inadequate therapy behavior is associated to disease flares in patients with rheumatoid arthritis who have achieved remission with disease-modifying antirheumatic drugs.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Health Behavior; Humans; Male; Methotrexate; Middle Aged; Patient Compliance; Prognosis; Prospective Studies; Remission Induction; Risk Factors; Surveys and Questionnaires; Treatment Outcome | 2010 |
PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Treatment Outcome | 2010 |
A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Basic Helix-Loop-Helix Transcription Factors; Cohort Studies; DNA-Binding Proteins; Genetic Markers; Humans; Intracellular Signaling Peptides and Proteins; Methotrexate; Middle Aged; Nuclear Proteins; Polymorphism, Single Nucleotide; Registries; Tumor Necrosis Factor alpha-Induced Protein 3 | 2012 |
PubMed had a higher sensitivity than Ovid-MEDLINE in the search for systematic reviews.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; MEDLINE; Methotrexate; PubMed; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Treatment Outcome | 2011 |
Pericarditis induced by prophylactic administration of isoniazid in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Humans; Isoniazid; Male; Methotrexate; Middle Aged; Pericarditis; Tuberculosis, Pulmonary | 2011 |
Classification of rheumatoid arthritis: comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria.
Topics: Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Sensitivity and Specificity; Severity of Illness Index | 2011 |
Chemotherapy in severe nasal polyposis--a possible beneficial effect? A report of three cases.
Topics: Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Female; Humans; Male; Methotrexate; Middle Aged; Multiple Myeloma; Nasal Polyps; Remission Induction | 2010 |
Improvements in patient-reported outcomes, symptoms of depression and anxiety, and their association with clinical remission among patients with moderate-to-severe active early rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Anxiety; Arthritis, Rheumatoid; Depression; Drug Therapy, Combination; Etanercept; Health Status; Humans; Immunoglobulin G; Logistic Models; Methotrexate; Middle Aged; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Self Report; Severity of Illness Index; Time Factors; Treatment Outcome | 2011 |
Factors associated with radiographic progression in patients with rheumatoid arthritis who were treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Disease Progression; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Logistic Models; Male; Methotrexate; Prognosis; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2011 |
The safety and effectiveness of a chloroform/methanol extract of Tripterygium wilfordii Hook F (T2) plus methotrexate in treating rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Chloroform; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methanol; Methotrexate; Middle Aged; Plant Extracts; Retrospective Studies; Treatment Outcome; Tripterygium | 2010 |
Observational cross-sectional study revealing less aggressive treatment in Japanese elderly than nonelderly patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Peptides, Cyclic; Receptors, Tumor Necrosis Factor; Rheumatoid Factor | 2010 |
[Unilateral odynophagia in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cooperative Behavior; Deglutition Disorders; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Dysphonia; Endoscopy; Female; Folic Acid; Humans; Interdisciplinary Communication; Lymphopenia; Methotrexate; Middle Aged; Misoprostol; Opportunistic Infections; Oral Ulcer; Pain; Pharyngitis; Prednisolone | 2011 |
The changing management of inflammatory arthritis.
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Prognosis; United Kingdom | 2010 |
Iatrogenic oral hairy leukoplakia: report of two cases.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Antifungal Agents; Arthritis, Rheumatoid; Clobetasol; Dapsone; Dermatologic Agents; Dexamethasone; Diabetes Mellitus, Type 2; Epstein-Barr Virus Infections; Female; Fluconazole; Humans; Immunocompromised Host; Leukoplakia, Hairy; Lichen Planus; Methotrexate; Nystatin; Prednisone; Zinc Oxide | 2011 |
Power estimation using a population pharmacokinetics model with optimal design by clinical trial simulations: application in pharmacokinetic drug-drug interaction studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Computer Simulation; Cost-Benefit Analysis; Drug Interactions; Humans; Methotrexate; Models, Biological; Sample Size | 2011 |
Eruptive molluscum contagiosums in a patient with rheumatoid arthritis and lung cancer.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunocompromised Host; Lung Neoplasms; Methotrexate; Molluscum Contagiosum; Pneumonectomy | 2011 |
Clinical significance of high levels of soluble tumour necrosis factor-α receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study.
Topics: Adult; Alternative Splicing; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Infliximab; Longitudinal Studies; Male; Matrix Metalloproteinase 1; Methotrexate; Middle Aged; Prospective Studies; Radiography; Receptors, Tumor Necrosis Factor, Type II; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Older age of rheumatoid arthritis onset is associated with higher activation status of peripheral blood CD4(+) T cells and disease activity.
Topics: Adult; Age of Onset; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; Cohort Studies; fas Receptor; Female; HLA-DR Antigens; Humans; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Prednisone; Severity of Illness Index; T-Lymphocytes, Regulatory | 2011 |
Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Time Factors | 2012 |
Effectiveness of biologic therapies for rheumatoid arthritis: an indirect comparisons approach.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Treatment Failure; Treatment Outcome | 2011 |
Regression of lymphoma after withdrawal of infliximab alone in an infliximab/methotrexate-treated RA patient.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Crohn Disease; Drug Therapy, Combination; Eye; Humans; Infliximab; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Risk Factors; Treatment Outcome; Withholding Treatment | 2011 |
How I treat LGL leukemia.
Topics: Anemia; Arthritis, Rheumatoid; Cyclosporine; Humans; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Methotrexate; Neutropenia | 2011 |
Subcutaneous methotrexate is well tolerated and superior to oral methotrexate in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; England; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult | 2010 |
Spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.
Topics: Aminopyridines; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Intracellular Signaling Peptides and Proteins; Methotrexate; Morpholines; Oxazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Syk Kinase | 2011 |
Methotrexate-associated lymphoplasmacytic lymphoma complicated with type 2 cryoglobulinemia.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cryoglobulinemia; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Methotrexate; Middle Aged | 2011 |
Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature.
Topics: Adenocarcinoma; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma; Carcinoma, Squamous Cell; Coloring Agents; Cortisone; Humans; Immunohistochemistry; Lung Neoplasms; Lymph Nodes; Male; Methotrexate; Middle Aged; Necrosis; Rheumatoid Nodule; Tumor Necrosis Factor-alpha | 2011 |
The cellular immune response to influenza vaccination is preserved in rheumatoid arthritis patients treated with rituximab.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antibodies, Viral; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Case-Control Studies; CD4-Positive T-Lymphocytes; Female; Hemagglutination Inhibition Tests; Humans; Immunity, Cellular; Immunity, Humoral; Influenza Vaccines; Influenza, Human; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Rituximab | 2011 |
Infliximab and brucellosis: not the usual suspects, this time.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Brucellosis; Drug Therapy, Combination; Humans; Immunocompromised Host; Infliximab; Male; Methotrexate; Middle Aged | 2011 |
Adenosine deaminase and C-reactive protein in diagnosing and monitoring of rheumatoid arthritis.
Topics: Adenosine Deaminase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Catalysis; Female; Humans; Male; Methotrexate; Middle Aged | 2011 |
[The future of methotrexate therapy and other folate inhibitors].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Folic Acid Antagonists; Forecasting; Humans; Methotrexate; Rheumatology | 2011 |
[Methotrexate toxicity. Myths and facts].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Evidence-Based Medicine; Humans; Methotrexate; Pneumonia; Risk Assessment | 2011 |
[Pharmacogenetics and pharmacogenomics of methotrexate. Current status and novel aspects].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Germany; Humans; Methotrexate; Pharmacogenetics | 2011 |
[Combination therapy using methotrexate with DMARDs or biologics--current status].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Combinations; Humans; Methotrexate; Treatment Outcome | 2011 |
Ultraviolet light-induced Köbner phenomenon contributes to the development of skin eruptions in multicentric reticulohistiocytosis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dermatologic Agents; Female; Histiocytosis; Humans; Methotrexate; Middle Aged; Prednisone; Skin Diseases; Sunscreening Agents; Ultraviolet Rays | 2011 |
Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged; Synovitis; Time Factors; Treatment Outcome | 2011 |
[Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy in Poland].
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2010 |
The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Databases, Factual; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Opportunistic Infections; Risk Assessment | 2011 |
Impact of concomitant use of DMARDs on the persistence with anti-TNF therapies in patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Drug Utilization; Epidemiologic Methods; Female; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Hemophagocytic syndrome in a patient with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphohistiocytosis, Hemophagocytic; Male; Methotrexate | 2011 |
Reduced-dose rituximab in rheumatoid arthritis: efficacy depends on degree of B cell depletion.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Flow Cytometry; Glucocorticoids; Humans; Lymphocyte Depletion; Male; Methotrexate; Methylprednisolone; Middle Aged; Predictive Value of Tests; Rituximab; Treatment Outcome | 2011 |
[Adverse effects of cyclosporin a observed in rheumatoid arthritis and psoriatic arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Creatinine; Cyclosporine; Diarrhea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Feeding and Eating Disorders; Female; Follow-Up Studies; Hirsutism; Humans; Hypertension; Male; Methotrexate; Middle Aged; Peripheral Nervous System Diseases; Tremor | 2010 |
Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Early Diagnosis; Female; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Male; Markov Chains; Methotrexate; Middle Aged; Netherlands; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Development of sarcoidosis 6-month post discontinuation of etanercept: coincidence or real association?
Topics: Abatacept; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography, Thoracic; Receptors, Tumor Necrosis Factor; Rituximab; Sarcoidosis; Treatment Outcome | 2011 |
Studies of the efficacy and safety of methotrexate at dosages over 8 mg/week using the IORRA cohort database.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Databases, Factual; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2011 |
Influence of immunogenicity on the efficacy of long-term treatment with infliximab in rheumatoid arthritis.
Topics: Antibodies; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2011 |
[Effect of methotrexate in treating patients with rheumatoid arthritis of different Chinese medical syndrome patterns].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Female; Humans; Male; Medicine, Chinese Traditional; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2011 |
In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kidney; Membrane Transport Proteins; Methotrexate; Neoplasm Proteins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Risk Assessment; Sulfasalazine; Xenopus laevis | 2011 |
Fatigue and severity of rheumatoid arthritis in Moroccan patients.
Topics: Adult; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Disability Evaluation; Educational Status; Fatigue; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Morocco; Quality of Life; Radiography; Severity of Illness Index; Sjogren's Syndrome; Smoking; Social Class; Surveys and Questionnaires; Treatment Outcome | 2012 |
[Clostridium difficile-associated diarrhea: causes and relationship to reactive arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clostridioides difficile; Enterocolitis, Pseudomembranous; Female; Humans; Methotrexate; Middle Aged; Naproxen; Risk Factors | 2011 |
Is there a need for immunopharmacologic guidance of anti-tumor necrosis factor therapies?
Topics: Adalimumab; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunogenetic Phenomena; Immunosuppressive Agents; Immunotherapy; Incidence; Methotrexate; Risk Factors; Thromboembolism; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Cytomegalovirus infection in a patient with rheumatoid arthritis on low-dose methotrexate.
Topics: Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Cytomegalovirus; Cytomegalovirus Infections; Dose-Response Relationship, Drug; Female; Ganciclovir; Humans; Immunocompromised Host; Injections, Intravenous; Methotrexate; Middle Aged; Treatment Outcome; Withholding Treatment | 2011 |
Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995-2007 versus 1985-1994: a population-based study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Female; Geography; Humans; Incidence; Male; Methotrexate; Middle Aged; Minnesota; Population Groups; Retrospective Studies; Rheumatoid Factor; Rheumatoid Vasculitis | 2011 |
Methotrexate and trimethoprim-sulfamethoxazole for Pneumocystis pneumonia prophylaxis.
Topics: Anti-Infective Agents; Arthritis, Rheumatoid; Contraindications; Humans; Immunosuppressive Agents; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Remission in inflammatory arthritis: a new immunological target.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Remission Induction; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2011 |
Secondary syphilis following tumor necrosis factor-α inhibitor treatment for rheumatoid arthritis.
Topics: Adalimumab; Amoxicillin; Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Methotrexate; Methylprednisolone; Middle Aged; Receptors, Tumor Necrosis Factor; Syphilis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
A change in treatment from etanercept to infliximab was effective to control scleritis in a patient with rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Infliximab; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor; Scleritis; Treatment Outcome | 2012 |
Bridging the gap between aggregate data and individual patient management: a Bayesian approach.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Data Collection; Decision Support Systems, Clinical; Evidence-Based Medicine; Health Status Indicators; Humans; Likelihood Functions; Methotrexate; Patient Care; Registries; Surveys and Questionnaires; Tumor Necrosis Factor-alpha | 2011 |
Pulmonary function test: its correlation with pulmonary high-resolution computed tomography in patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Female; Humans; Lung; Methotrexate; Middle Aged; Respiratory Function Tests; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Mastocytic enterocolitis as a rare cause of chronic diarrhea in a patient with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Biopsy; Chronic Disease; Diagnosis, Differential; Diarrhea; Drug Therapy, Combination; Enterocolitis; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Immunoglobulin E; Intestinal Mucosa; Loratadine; Male; Mast Cells; Mastocytosis; Methotrexate; Middle Aged; Ranitidine; Tryptases | 2011 |
[The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 1)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic | 2011 |
[The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 2)].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic | 2011 |
Coexistence of ankylosing spondylitis and rheumatoid arthritis in a female patient.
Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Methylprednisolone; Middle Aged; Radiography; Recovery of Function; Spine; Spondylitis, Ankylosing; Treatment Outcome | 2011 |
Pneumococcal antibody levels after pneumovax in patients with rheumatoid arthritis on methotrexate.
Topics: Aged; Antibodies, Bacterial; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumococcal Vaccines; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Vaccination | 2011 |
Comparison of QuantiFERON-TB Gold and the tuberculin skin test for detecting previous tuberculosis infection evaluated by chest CT findings in Japanese rheumatoid arthritis patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bacteriological Techniques; BCG Vaccine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma; Japan; Male; Methotrexate; Middle Aged; Prednisolone; Radiography, Thoracic; Tuberculin Test; Tuberculosis | 2011 |
Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immune Tolerance; Inflammation; Male; Methotrexate; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
BSR and BHPR guidelines on the use of rituximab in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Drug Therapy, Combination; Humans; Methotrexate; Rituximab; Tumor Necrosis Factor-alpha | 2011 |
Biologics in rheumatoid arthritis--recommendations for Swiss practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Methotrexate; Remission Induction; Switzerland; Tumor Necrosis Factor-alpha | 2011 |
Combined treatment of etanercept and MTX reverses Th1/Th2, Th17/Treg imbalance in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cytokines; Enzyme-Linked Immunosorbent Assay; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Th1-Th2 Balance; Th17 Cells | 2011 |
The influence of rheumatoid arthritis disease characteristics on heart failure.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Heart Failure; Humans; Methotrexate; Middle Aged; Risk Factors | 2011 |
Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Severity of Illness Index; Young Adult | 2011 |
Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sickness Impact Profile; Smoking; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2011 |
Induction of clinical remission with adalimumab-methotrexate combination therapy in a patient with rheumatoid arthritis and concomitant hepatitis C virus infection.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Hepatitis C; Humans; Methotrexate; Remission Induction; Treatment Outcome | 2011 |
Oligosymptomatic herpetic hepatitis in a patient with rheumatoid arthritis using corticosteroid and methotrexate.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Causality; Drug Therapy, Combination; Female; Hepatitis, Viral, Human; Hepatocytes; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate | 2011 |
Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK.
Topics: Adult; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biopterins; Cell Line, Tumor; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; Methotrexate; Middle Aged; Reactive Oxygen Species; Tumor Cells, Cultured | 2011 |
Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Osteogenesis; Sclerosis; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha | 2011 |
Diagnostic performance of the ACR/EULAR 2010 criteria for rheumatoid arthritis and two diagnostic algorithms in an early arthritis clinic (REACH).
Topics: Adult; Aged; Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Middle Aged | 2011 |
Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors α and β: correlation with methotrexate efficacy in rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blotting, Western; Chile; Diclofenac; Female; Glucocorticoids; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Prednisolone; Protein Isoforms; Receptors, Glucocorticoid; Treatment Outcome | 2011 |
Implementation of a treat-to-target strategy in very early rheumatoid arthritis: results of the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2011 |
Investigation of the association between metabolic syndrome and disease activity in rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Iran; Logistic Models; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Prednisolone; Prevalence; Risk Assessment | 2011 |
Baseline characteristics and patient reported outcome data of patients prescribed etanercept: web-based and telephone evaluation.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Interviews as Topic; Male; Methotrexate; Middle Aged; Online Systems; Psoriasis; Quality of Life; Receptors, Tumor Necrosis Factor; Self Report; Spondylarthropathies; Telephone; Treatment Outcome | 2011 |
Methotrexate attenuates the Th17/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; CD28 Antigens; CD3 Complex; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Interleukin-17; Male; Methotrexate; Middle Aged; RNA, Messenger; Th17 Cells; Young Adult | 2012 |
[Rheumatoid arthritis: early detection - early treatment. Lasting remission: a realistic therapy goal].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Diagnosis, Differential; Early Diagnosis; Humans; Immunosuppressive Agents; Long-Term Care; Methotrexate; Prognosis | 2011 |
Letter: A case of generalized guttate psoriasis induced by etanercept with relapse after abatacept.
Topics: Abatacept; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoconjugates; Immunoglobulin G; Methotrexate; Middle Aged; Psoriasis; Receptors, Tumor Necrosis Factor; Rituximab; Steroids | 2011 |
Very early improvements in the wrist and hand assessed by power Doppler sonography predicting later favorable responses in tocilizumab-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Finger Joint; Humans; Japan; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Observer Variation; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Severity of Illness Index; Time Factors; Treatment Outcome; Ultrasonography, Doppler; Wrist Joint | 2011 |
Etanercept in combination with conventional disease-modifying antirheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis patients intolerant to methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Substitution; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Joints; Male; Methotrexate; Middle Aged; Pain Measurement; Receptors, Tumor Necrosis Factor; Recovery of Function; Retrospective Studies; Severity of Illness Index; Sulfasalazine; Treatment Failure | 2012 |
Methotrexate-associated lymphoproliferative disorder presenting as disseminated malignancy.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Lymphoproliferative Disorders; Male; Methotrexate; Neoplasms, Unknown Primary; Pleural Effusion; Withholding Treatment | 2011 |
Efficacy of rituximab in the treatment of rheumatoid arthritis. Influence of serologic status, coprescription of methotrexate and prior TNF-alpha inhibitors exposure.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retreatment; Retrospective Studies; Rheumatoid Factor; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Breast lymphoma complicating anti-tumor necrosis factor therapy in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Etanercept; Female; Humans; Immunoglobulin G; Lymphoma; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2011 |
Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cullin Proteins; Female; Gene Frequency; Genetic Association Studies; Haplotypes; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2011 |
Post-chikungunya chronic arthritis--our experience with DMARDs over two year follow up.
Topics: Adult; Aged; Alphavirus Infections; Antirheumatic Agents; Arthritis, Rheumatoid; Chikungunya Fever; Chikungunya virus; Chronic Disease; Drug Therapy, Combination; Epidemics; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Young Adult | 2011 |
Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients--REACTION 52-week study.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disability Evaluation; Drug Therapy, Combination; Female; Glucocorticoids; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Recovery of Function; Remission Induction; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2011 |
Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Disease Progression; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Severity of Illness Index; Sulfasalazine; Tacrolimus; Treatment Outcome | 2012 |
Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cross-Sectional Studies; Female; Gene Frequency; Haplotypes; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Republic of Korea; Risk Assessment; Risk Factors | 2012 |
Rheumatoid arthritis decision making: many information sources but not all rated as useful.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Data Collection; Decision Making; Female; Humans; Information Services; Internet; Interviews as Topic; Male; Methotrexate; Middle Aged; Patient Education as Topic; Patient Participation; Physician-Patient Relations; Pilot Projects | 2011 |
[Methotrexate-induced changes in the concentration of antibodies to mutaded citrullinated vimentin in blood serum of patients with rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Mutation; Vimentin | 2011 |
The Peters anomaly following antenatal exposure to methotrexate and hydroxychloroquine.
Topics: Anterior Eye Segment; Antirheumatic Agents; Arthritis, Rheumatoid; Corneal Opacity; Enzyme Inhibitors; Eye Abnormalities; Female; Humans; Hydroxychloroquine; Infant, Newborn; Methotrexate; Pregnancy; Prenatal Exposure Delayed Effects | 2011 |
Osteoprotegerin expression in bone marrow by treatment with tocilizumab in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Marrow; Case-Control Studies; Humans; Interleukin-6; Methotrexate; Middle Aged; Osteopontin; Osteoprotegerin; RANK Ligand; Receptors, Interleukin-6; Tumor Necrosis Factor-alpha | 2012 |
[Certolizumab pegol].
Topics: Adult; Animals; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Male; Methotrexate; Mice; Middle Aged; Multicenter Studies as Topic; Polyethylene Glycols; Pregnancy; Pregnancy Complications; Quality of Life; Tumor Necrosis Factor-alpha | 2011 |
[Amyloid goiter secondary to rheumatoid arthritis. a case report].
Topics: Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Deglutition Disorders; Dyspnea; Female; Gastric Mucosa; Goiter, Nodular; Humans; Kidney; Methotrexate; Middle Aged; Prednisone; Thyroidectomy | 2012 |
Absent "Window of Opportunity" in smokers with short disease duration. Data from BARFOT, a multicenter study of early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Health Status; Humans; Inflammation; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Smoking; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2011 |
Decrease of CD68 and MMP-3 expression in synovium by treatment of adalimumab for rheumatoid arthritis.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Proliferation; Drug Therapy, Combination; Female; Humans; Immunohistochemistry; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Synovial Membrane | 2011 |
[Extranodal NK/T-cell lymphoma, nasal type, developed in a patient with rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Killer Cells, Natural; Lymphoma, T-Cell; Male; Methotrexate; Nose Neoplasms; Receptors, Tumor Necrosis Factor | 2011 |
[B-cell lymphoma possessing t(14;18)(q32;q21)in a patient with rheumatoid arthritis receiving methotrexate treatment].
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Female; Herpesvirus 4, Human; Humans; Lymphoma, B-Cell; Methotrexate | 2011 |
[Against parenteral gold therapy in rheumatoid arthritis].
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Biological Products; Drug Substitution; Evidence-Based Medicine; Gold Compounds; Gold Sodium Thiomalate; Humans; Infusions, Intravenous; Methotrexate; Treatment Outcome | 2011 |
National EQ-5D tariffs and quality-adjusted life-year estimation: comparison of UK, US and Danish utilities in south Swedish rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Cultural Comparison; Denmark; Drug Therapy, Combination; Health Status Indicators; Humans; Methotrexate; Psychometrics; Quality-Adjusted Life Years; Sweden; Tumor Necrosis Factor-alpha; United Kingdom; United States | 2011 |
Reduced seroprotection after pandemic H1N1 influenza adjuvant-free vaccination in patients with rheumatoid arthritis: implications for clinical practice.
Topics: Adjuvants, Immunologic; Adult; Aged; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Immunosuppressive Agents; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2011 |
Comparative effectiveness of rituximab in combination with either methotrexate or leflunomide in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome | 2011 |
Treatment strategies in patients with rheumatoid arthritis for whom methotrexate monotherapy has failed: data from the NOR-DMARD register.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Male; Medication Adherence; Methotrexate; Middle Aged; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Intestinal perforation due to concomitant cytomegalovirus infection during treatment for Pneumocystis jirovecii pneumonia in a patient with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Cytomegalovirus Infections; Fatal Outcome; Female; Humans; Intestinal Perforation; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Treatment Outcome | 2011 |
Adalimumab-associated pulmonary cryptococcosis.
Topics: Adalimumab; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cryptococcosis; Cryptococcus neoformans; Drug Therapy, Combination; Female; Humans; Isoniazid; Lung Diseases; Methotrexate; Middle Aged; Thoracic Surgery, Video-Assisted; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
[Methotrexate treatment of rheumatoid arthritis in Denmark].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Denmark; Humans; Medication Adherence; Methotrexate; Radiography; Treatment Outcome | 2011 |
[Methotrexate-related lymphomatoid granulomatosis in a patient with rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphomatoid Granulomatosis; Male; Methotrexate | 2011 |
Rheumatoid arthritis in patients with hemoglobinopathies.
Topics: Adult; Anemia, Sickle Cell; Arthritis, Rheumatoid; Autoantibodies; beta-Thalassemia; Cohort Studies; Comorbidity; Female; Humans; Male; Methotrexate; Middle Aged; Prevalence; Radiography; Retrospective Studies; Steroids | 2012 |
Effectiveness and safety of adalimumab in Japanese patients with rheumatoid arthritis: retrospective analyses of data collected during the first year of adalimumab treatment in routine clinical practice (HARMONY study).
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Disease Progression; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Radiography; Remission Induction; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
[Autoimmune pancreatitis associated with rheumatoid arthritis: successful combination therapy with steroids and methotrexate].
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Biopsy; Comorbidity; Diabetes Mellitus; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Metacarpophalangeal Joint; Methotrexate; Pancreas; Pancreatitis; Prednisolone; Treatment Outcome | 2011 |
Reactivation of hepatitis B virus in a hepatitis B surface antigen-negative patient with rheumatoid arthritis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Methotrexate; Middle Aged; Virus Activation | 2012 |
Efficacy of leflunomide addition in relation to prognostic factors for patients with active early rheumatoid arthritis failing to methotrexate in daily practice.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Female; Humans; Isoxazoles; Joints; Leflunomide; Male; Methotrexate; Middle Aged; Prognosis; Range of Motion, Articular; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2012 |
Merging Veterans Affairs rheumatoid arthritis registry and pharmacy data to assess methotrexate adherence and disease activity in clinical practice.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Data Mining; Female; Humans; Insurance, Pharmaceutical Services; Male; Medication Adherence; Methotrexate; Middle Aged; Multivariate Analysis; Propensity Score; Prospective Studies; Registries; Regression Analysis; Severity of Illness Index; Time Factors; Treatment Outcome; United States; United States Department of Veterans Affairs | 2011 |
Inhibition of MAP kinase in synovium by treatment with tocilizumab in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Female; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Synovial Membrane; Vascular Endothelial Growth Factor A | 2011 |
[Recurrent cardiac tamponade and sepsis in a patient with rheumatoid arthritis].
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cardiac Tamponade; Colchicine; Echocardiography; Enterobacter cloacae; Enterobacteriaceae Infections; Fatal Outcome; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Pericarditis; Sepsis; Tomography, X-Ray Computed | 2011 |
Liver stiffness correlates with methotrexate cumulative dose in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Elasticity; Elasticity Imaging Techniques; Female; Follow-Up Studies; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies | 2012 |
Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation.
Topics: Arthritis, Rheumatoid; Bone Resorption; Drug Therapy, Combination; Humans; Methotrexate; Osteogenesis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Chromosome Aberrations; Epstein-Barr Virus Infections; Female; Flow Cytometry; Humans; Immunocompromised Host; Immunohistochemistry; Karyotype; Ki-1 Antigen; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prognosis; Survival Analysis | 2012 |
Clinical significance of autoantibodies induced by infliximab treatment: two-year follow-up after infliximab discontinuation.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Female; Humans; Infliximab; Male; Methotrexate; Tumor Necrosis Factor-alpha | 2011 |
Methotrexate pneumonitis in rheumatoid arthritis: increased prevalence with increasing latitude: an epidemiological study of trends in new zealand.
Topics: Aged; Aged, 80 and over; Altitude; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; New Zealand; Pneumonia; Prevalence; Risk Factors | 2011 |
Successful use of tocilizumab in a patient with rheumatoid arthritis following severe pancytopenia during etanercept therapy.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Methylprednisolone; Pancytopenia; Receptors, Tumor Necrosis Factor | 2011 |
New biologics for rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Humans; Interleukin-6; Joints; Methotrexate; Tumor Necrosis Factors | 2011 |
Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints.
Topics: Adalimumab; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Remission Induction; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
Disability in rheumatoid arthritis in the era of biological treatments.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Body Mass Index; Disability Evaluation; Drug Utilization; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prospective Studies; Smoking; Treatment Outcome; United States | 2012 |
Prescribing practices in a US cohort of rheumatoid arthritis patients before and after publication of the American College of Rheumatology treatment recommendations.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Female; Guidelines as Topic; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Practice Patterns, Physicians'; Prognosis; Prospective Studies; Quality of Health Care; Registries; Severity of Illness Index; Surveys and Questionnaires | 2012 |
Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry.
Topics: Arthritis, Rheumatoid; Erythrocytes; Humans; Linear Models; Methotrexate; Polyglutamic Acid; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Time Factors | 2011 |
Heptavalent pneumococcal conjugate vaccine elicits similar antibody response as standard 23-valent polysaccharide vaccine in adult patients with RA treated with immunomodulating drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Heptavalent Pneumococcal Conjugate Vaccine; Humans; Immunoglobulin G; Immunomodulation; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Streptococcus pneumoniae; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2012 |
Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Drug Therapy, Combination; Dyspnea; Female; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Methotrexate; Middle Aged; Peptides, Cyclic; Radiography; Receptors, Interleukin-6; Rheumatoid Factor; Steroids | 2011 |
Rheumatoid meningitis occurring during adalimumab and methotrexate treatment.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Meningitis; Methotrexate; Middle Aged; Prednisone; Rituximab; Treatment Outcome | 2012 |
A case of organizing pneumonia induced by tocilizumab.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pneumonia; Receptors, Interleukin-6 | 2011 |
Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Erythrocytes; Female; Humans; Injections, Subcutaneous; Methotrexate; Middle Aged; Polyglutamic Acid | 2011 |
Prognosis of pneumocystis pneumonia complicated in patients with rheumatoid arthritis (RA) and non-RA rheumatic diseases.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Japan; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Prognosis; Retrospective Studies; Survival Rate | 2012 |
Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Rituximab; Treatment Outcome | 2012 |
Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of the first 3,000 patients.
Topics: Adalimumab; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Glucocorticoids; Health Status; Humans; Japan; Joints; Lung Diseases; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Risk Assessment; Severity of Illness Index; Treatment Outcome; Young Adult | 2012 |
Aggressive cutaneous infection with Mycobacterium marinum in two patients receiving anti-tumor necrosis factor-alfa agents.
Topics: Adult; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Bacterial Typing Techniques; Clarithromycin; Ethambutol; Female; Fingers; Fishes; Hand Dermatoses; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Methotrexate; Middle Aged; Minocycline; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Rifabutin; Skin Diseases, Bacterial; Tumor Necrosis Factor-alpha | 2011 |
Treatment of refractory tumor necrosis factor inhibitor-induced palmoplantar pustulosis: a report of 2 cases.
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Alefacept; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Crohn Disease; Cyclosporine; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Mycophenolic Acid; Psoriasis; PUVA Therapy; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Treatment Outcome; Ustekinumab | 2011 |
Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4⁺ T cells (Th17) cells in collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; CD4 Antigens; Collagen Type I; Disease Models, Animal; Disease Progression; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Immunomodulation; Immunotherapy; Interleukin-17; Joints; Methotrexate; Mice; Mice, Inbred DBA; Polymerization; T-Lymphocytes, Regulatory; Th17 Cells | 2012 |
Low-dose tacrolimus with methotrexate repairs rheumatoid fingers.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Fingers; Humans; Methotrexate; Radiography; Tacrolimus | 2011 |
Importance of correlation between gene expression levels: application to the type I interferon signature in rheumatoid arthritis.
Topics: Adult; Algorithms; Arthritis, Rheumatoid; Case-Control Studies; Cluster Analysis; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Interferon Type I; Lupus Erythematosus, Systemic; Male; Methods; Methotrexate; Middle Aged | 2011 |
The C677T polymorphism in the MTHFR gene is associated with the toxicity of methotrexate in a Spanish rheumatoid arthritis population.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Genotype; Haplotypes; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Retrospective Studies; Spain | 2012 |
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Genetic Association Studies; Humans; Inosine Triphosphatase; Male; Metabolic Networks and Pathways; Methotrexate; Middle Aged; Multifactor Dimensionality Reduction; Peptides, Cyclic; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polymorphism, Single Nucleotide; Pyrophosphatases; Reduced Folate Carrier Protein; Sex Factors | 2012 |
Biological drug treatment of rheumatoid arthritis and spondyloarthritis: effects on QT interval and QT dispersion.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Electrocardiography; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Myocardial Contraction; Receptors, Tumor Necrosis Factor; Retrospective Studies; Rituximab; Spondylarthritis; Tumor Necrosis Factor-alpha | 2012 |
Modern treatment strategies in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Betamethasone; Cohort Studies; Cyclosporine; Etanercept; Female; Humans; Immunoglobulin G; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Prognosis; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Plasma leptin and neuropeptide Y concentrations in patients with rheumatoid arthritis treated with infliximab, a TNF-α antagonist.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Drug Therapy, Combination; Female; Humans; Infliximab; Leptin; Methotrexate; Neuropeptide Y; Prednisone; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Bone marrow gold.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Female; Gold Sodium Thiomalate; Humans; Methotrexate; Middle Aged; Neutropenia | 2012 |
[Methotrexate-related deaths in patients with rheumatoid arthritis].
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cause of Death; Dose-Response Relationship, Drug; Drug Administration Schedule; Homes for the Aged; Humans; Male; Medication Errors; Methotrexate; Nursing Homes; Risk Factors | 2011 |
[Visceral leishmaniasis in two patients treated with methotrexate for rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Leishmaniasis, Visceral; Male; Methotrexate; Middle Aged | 2012 |
Effect of methotrexate on inflammatory cells redistribution in experimental adjuvant arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage, Articular; gamma-Glutamyltransferase; Granulocytes; Knee Joint; Male; Methotrexate; Rats; Rats, Inbred Lew; Spleen; Synovial Membrane; Thymus Gland | 2012 |
Proposed severity and response criteria for Routine Assessment of Patient Index Data (RAPID3): results for categories of disease activity and response criteria in abatacept clinical trials.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Immunoconjugates; Methotrexate; Pain Measurement; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2011 |
Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery.
Topics: Administration, Cutaneous; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Death; Cell Membrane Permeability; Cytokines; Dose-Response Relationship, Drug; Drug Delivery Systems; Etanercept; Immunoglobulin G; Inflammation Mediators; Kinetics; Male; Methotrexate; Mice; Receptors, Tumor Necrosis Factor; Tetrahydrofolate Dehydrogenase; Tissue Distribution; Treatment Outcome; X-Ray Microtomography | 2012 |
Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infliximab; Logistic Models; Male; Methotrexate; Pain Measurement; Prednisone; Prognosis; Radiography; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2012 |
Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multidrug Resistance-Associated Protein 2; Polymorphism, Genetic; Retrospective Studies; Treatment Outcome | 2012 |
Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Narcotics; Retrospective Studies; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Autoimmune hepatitis after long-term methotrexate therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Chemical and Drug Induced Liver Injury; Glucocorticoids; Hepatitis, Autoimmune; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged | 2011 |
Clinical results for tocilizumab over one year in the clinical setting as assessed by CDAI (clinical disease activity index): CRP at week 12 and MMP-3 at week 24 are predictive factors for CDAI.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Remission Induction; Severity of Illness Index; Treatment Outcome | 2012 |
Misclassification of disease activity when assessing individual patients with early rheumatoid arthritis using disease activity indices that do not include joints of feet.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cohort Studies; Diagnostic Errors; Disease Progression; Early Diagnosis; Female; Foot Joints; Hand Joints; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Rheumatoid Factor; Severity of Illness Index | 2012 |
Tumor necrosis factor blockade differentially affects innate inflammatory and Th17 cytokines in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Etanercept; Female; Humans; Immunity, Innate; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Th17 Cells; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Response to traditional disease-modifying anti-rheumatic drugs in indigent South Africans with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Poverty; Prednisone; Radiography; Severity of Illness Index; South Africa; Sulfasalazine; Treatment Outcome; Uncompensated Care | 2012 |
[The other opinion: nephrotoxicity of low-dose methotrexate - a problem which does not exist].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Renal Insufficiency | 2011 |
Methotrexate-related minor adverse effects in rheumatoid arthritis: more than a nuisance.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Surveys and Questionnaires | 2012 |
Effectiveness of sulfasalazine and methotrexate in 1102 DMARD-naive patients with early RA.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Evaluation; Female; Humans; Immunosuppressive Agents; Longitudinal Studies; Male; Medication Adherence; Methotrexate; Middle Aged; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2012 |
Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocyte Subsets; B-Lymphocytes; Cells, Cultured; Cohort Studies; Etanercept; Female; Humans; Immunoglobulin G; Immunologic Memory; Infliximab; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2011 |
Methotrexate increases expression of cell cycle checkpoint genes via JNK activation.
Topics: Adult; Aged; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cell Cycle Checkpoints; Female; Flow Cytometry; Humans; Male; MAP Kinase Signaling System; Methotrexate; Middle Aged; Reactive Oxygen Species | 2012 |
Visceral leishmaniasis in a rheumatoid arthritis patient treated with methotrexate.
Topics: Aged; Amphotericin B; Antiprotozoal Agents; Arthritis, Rheumatoid; Fatigue; Female; Fluorescent Antibody Technique, Indirect; Hepatomegaly; Humans; Immunosuppressive Agents; Leishmania; Leishmaniasis, Visceral; Methotrexate; Splenomegaly; Tomography, X-Ray Computed | 2012 |
A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry.
Topics: Adult; Aged; Ambulatory Care Facilities; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Netherlands; Registries; Remission Induction; Severity of Illness Index; Sulfasalazine | 2012 |
Immunohistological analysis of synovium treated with abatacept in rheumatoid arthritis.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Biomarkers; Case-Control Studies; Cell Proliferation; Female; Humans; Immunoconjugates; Immunohistochemistry; Inflammation Mediators; Male; Methotrexate; Middle Aged; Synovial Membrane; T-Lymphocytes; Treatment Outcome | 2013 |
Posterior reversible encephalopathy syndrome and oral methotrexate.
Topics: Aged; Anticonvulsants; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Brain; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Phenytoin; Posterior Leukoencephalopathy Syndrome; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Effect of golimumab combined with methotrexate on radiographic progression in rheumatoid arthritis: comment on the article by Emery et al.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Radiography | 2012 |
FcγRIIIa expression on monocytes in rheumatoid arthritis: role in immune-complex stimulated TNF production and non-response to methotrexate therapy.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Female; Gene Expression Regulation; Humans; Lipopolysaccharide Receptors; Male; Methotrexate; Middle Aged; Monocytes; Receptors, IgG; Retrospective Studies; Steroids; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Bosentan, an endothelin receptor antagonist, ameliorates collagen-induced arthritis: the role of TNF-α in the induction of endothelin system genes.
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bosentan; Cells, Cultured; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Female; Gene Expression Profiling; Humans; Leukocytes, Mononuclear; Lymph Nodes; Male; Methotrexate; Mice; Mice, Inbred DBA; Middle Aged; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Sulfonamides | 2012 |
[Case report; a case suspected that methotrexate-associated lymphoproliferative disorders was developed in the course of therapy of rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoproliferative Disorders; Male; Methotrexate | 2011 |
Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Cross-Sectional Studies; Disease Progression; Female; Foot; Hand; Humans; Infliximab; Inhibitor of Apoptosis Proteins; Male; Membrane Proteins; Methotrexate; Middle Aged; Predictive Value of Tests; Radiography; S100 Calcium-Binding Protein A4; S100 Proteins; Survivin | 2012 |
Perspectives on rheumatoid arthritis for the orthopedic surgeon: overview of non-tumor necrosis factor biologic drugs and perioperative management.
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Orthopedics; Perioperative Care; Practice Guidelines as Topic; Rituximab; Standard of Care | 2011 |
[Early and advanced rheumatoid arthritis. Diagnosis and state of the art therapy strategy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Humans; Magnetic Resonance Imaging; Methotrexate; Secondary Prevention | 2012 |
Differential drug retention between anti-TNF agents and alternative biological agents after inadequate response to an anti-TNF agent in rheumatoid arthritis patients.
Topics: Abatacept; Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Immunoconjugates; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Proportional Hazards Models; Registries; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Methotrexate and post operative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery--a ten year follow-up.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Postoperative Complications; Risk Factors; Surgical Wound Infection | 2011 |
Adverse effects of low dose methotrexate in rheumatoid arthritis patients.
Topics: Acute Kidney Injury; Adolescent; Adult; Age Distribution; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Blood Chemical Analysis; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Leukopenia; Liver; Male; Methotrexate; Middle Aged; Pancytopenia; Prognosis; Risk Assessment; ROC Curve; Severity of Illness Index; Sex Distribution; Thrombocytopenia; Young Adult | 2012 |
Recent trends in use of nonbiologic DMARDs and evaluation of their continuation rates in single and dual combination therapies in rheumatoid arthritis patients in Japan.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Practice Patterns, Physicians'; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2012 |
[A rare complication in a patient with rheumatoid arthritis: sudden appearance of nodules on the forearm].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Methotrexate; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Opportunistic Infections; Skin Diseases, Bacterial; Tumor Necrosis Factor-alpha | 2012 |
Effect of additional administration of tacrolimus in patients with rheumatoid arthritis treated with biologics.
Topics: Aged; Arthritis, Rheumatoid; Biological Products; Blood Sedimentation; C-Reactive Protein; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Tacrolimus | 2011 |
Abatacept versus other biologics in methotrexate inadequate responders with rheumatoid arthritis: you like tomato and I like tomahto... let's call the whole thing off.
Topics: Arthritis, Rheumatoid; Biological Products; Humans; Immunoconjugates; Methotrexate | 2012 |
[Misleading improvement of abdominal tuberculosis with amikacin, within 72 hours].
Topics: Adrenal Cortex Hormones; Adult; Amikacin; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Drug Resistance, Microbial; Drug Therapy, Combination; Etanercept; Female; Humans; Immunocompromised Host; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Penicillanic Acid; Peritonitis, Tuberculous; Piperacillin; Piperacillin, Tazobactam Drug Combination; Receptors, Tumor Necrosis Factor; Recurrence; Streptomycin; Time Factors; Tuberculosis, Splenic | 2012 |
Tocilizumab has no clinically relevant effects on methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; C-Reactive Protein; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 2012 |
The challenges of methotrexate pharmacogenetics in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 2012 |
Twelve years' experience with etanercept in the treatment of rheumatoid arthritis: how it has changed clinical practice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Synergism; Etanercept; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Infections; Lymphoma; Methotrexate; Practice Patterns, Physicians'; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha | 2012 |
Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Female; Galactose; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Polysaccharides; Predictive Value of Tests; Tumor Necrosis Factor-alpha | 2012 |
Combination therapy including glucocorticoids: the new gold standard for early treatment in rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Prednisone; Radiography | 2012 |
Summaries for patients. Adding low-dose prednisone to methotrexate therapy for early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisone; Radiography; Remission Induction; Treatment Outcome | 2012 |
Adrenergic urticaria and rheumatoid arthritis in a patient with melanoma: an intricate medical management.
Topics: Adrenergic beta-Antagonists; Arthritis, Rheumatoid; Female; Glucocorticoids; Histamine Antagonists; Humans; Immunosuppressive Agents; Melanoma; Methotrexate; Middle Aged; Propranolol; Stress, Psychological; Urticaria | 2012 |
New insight into rheumatoid arthritis management. The disease and the drugs used to treat it have been linked to cardiovascular disease, melanoma, and fracture.
Topics: Adult; Age Factors; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Female; Fractures, Bone; Humans; Male; Melanoma; Methotrexate; Middle Aged; Risk Factors; Skin Neoplasms | 2012 |
Endothelial function improves within 6 weeks of treatment with methotrexate or methotrexate in combination with a TNF-α inhibitor in rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Plethysmography; Prospective Studies; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2012 |
Combination etanercept and methotrexate provides better disease control in very early (<=4 months) versus early rheumatoid arthritis (>4 months and <2 years): post hoc analyses from the COMET study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Early Diagnosis; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Proinflammatory and anti-inflammatory cytokines in gingival crevicular fluid and serum of patients with rheumatoid arthritis and patients with chronic periodontitis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chronic Periodontitis; Cross-Sectional Studies; Cytokines; Dental Plaque Index; Female; Gingival Crevicular Fluid; Humans; Immunosuppressive Agents; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-4; Male; Methotrexate; Middle Aged; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Sulfasalazine; Tumor Necrosis Factor-alpha; Young Adult | 2013 |
Methotrexate therapy, rheumatoid arthritis, and life-threatening liver complications: should we be monitoring more closely?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Methotrexate; Withholding Treatment | 2012 |
Limited end-user knowledge of methotrexate despite patient education: an assessment of rheumatologic preventive practice and effectiveness.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Audit; Cohort Studies; Female; Guideline Adherence; Health Knowledge, Attitudes, Practice; Humans; Life Style; Male; Methotrexate; Middle Aged; Patient Education as Topic; Pregnancy; Risk Reduction Behavior; Surveys and Questionnaires | 2012 |
Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Gene Frequency; Genetic Association Studies; Genotype; Humans; Hydroxymethyl and Formyl Transferases; Male; Metabolic Networks and Pathways; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide | 2013 |
Definition of treatment response in rheumatoid arthritis based on the simplified and the clinical disease activity index.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Clinical Trials as Topic; Female; Health Status; Humans; Infliximab; Joints; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Severity of Illness Index; Treatment Outcome | 2012 |
Towards an optimum strategy in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Female; Humans; Infliximab; Male; Methotrexate; Tumor Necrosis Factor-alpha | 2012 |
Tumor necrosis factor-α inhibitor use is not associated with lipid changes in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Female; Humans; Lipid Metabolism; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies; Triglycerides; Tumor Necrosis Factor-alpha | 2012 |
Tight control early rheumatoid arthritis clinic in Hong Kong: a pilot study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Pilot Projects; Prospective Studies; Sulfasalazine | 2012 |
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Female; Genome-Wide Association Study; Humans; Interleukin-6; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2013 |
A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Squamous Cell; Fatal Outcome; Female; Granulomatosis with Polyangiitis; Humans; Lung Neoplasms; Methotrexate; Middle Aged; Referral and Consultation; Retrospective Studies; Rituximab; Sarcoma; Smoking; Tumor Necrosis Factor-alpha | 2013 |
What is the future of CCR5 antagonists in rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Cyclohexanes; Female; Humans; Male; Methotrexate; Triazoles | 2012 |
Optimization of literature searching.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; PubMed; Randomized Controlled Trials as Topic | 2012 |
[Sulphasalazine in patients with rheumatoid arthritis in China: a cross-sectional study].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; China; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Sulfasalazine; Surveys and Questionnaires | 2012 |
Methotrexate (MTX)-cIBR conjugate for targeting MTX to leukocytes: conjugate stability and in vivo efficacy in suppressing rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Carriers; Drug Stability; Freund's Adjuvant; Half-Life; Humans; Hydrogen-Ion Concentration; Lymphocyte Function-Associated Antigen-1; Methotrexate; Peptides, Cyclic; Rats; T-Lymphocytes; Technology, Pharmaceutical; Time Factors | 2012 |
A retrospective study of serum KL-6 levels during treatment with biological disease-modifying antirheumatic drugs in rheumatoid arthritis patients: a report from the Ad Hoc Committee for Safety of Biological DMARDs of the Japan College of Rheumatology.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Mucin-1; Retrospective Studies; Treatment Outcome | 2013 |
Effect of ESR1 and ESR2 gene polymorphisms on rheumatoid arthritis treatment with methotrexate.
Topics: Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Genotype; Humans; Methotrexate; Middle Aged; Polymorphism, Genetic | 2012 |
Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Receptors, Interleukin-6; X-Ray Microtomography | 2013 |
Methotrexate reduces immunogenicity in adalimumab treated rheumatoid arthritis patients in a dose dependent manner.
Topics: Adalimumab; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunogenetic Phenomena; Immunosuppressive Agents; Methotrexate | 2012 |
Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Certolizumab Pegol; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Methotrexate; Middle Aged; Mucin-1; Polyethylene Glycols; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Treatment with biologic agents improves the prognosis of patients with rheumatoid arthritis and amyloidosis.
Topics: Adolescent; Adult; Aged; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Child; Female; Humans; Interleukin-6; Methotrexate; Middle Aged; Prognosis; Serum Amyloid A Protein; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Carotid atherosclerosis, disease measures, oxidized low-density lipoproteins, and atheroprotective natural antibodies for cardiovascular disease in early rheumatoid arthritis -- an inception cohort study.
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Comorbidity; Disability Evaluation; Disease Progression; Female; Health Status; Humans; Immunity, Innate; Incidence; Lipoproteins, LDL; Male; Methotrexate; Middle Aged; Phosphorylcholine; Prospective Studies; Severity of Illness Index; Survival Rate; Sweden; Ultrasonography | 2012 |
Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA.
Topics: Adolescent; Adult; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cartilage Oligomeric Matrix Protein; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Male; Matrilin Proteins; Methotrexate; Mice; Mice, Transgenic; Middle Aged; Osteoarthritis; Recombinant Fusion Proteins; Synovial Fluid; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blotting, Western; Female; Glucocorticoids; Humans; Hydroxyprostaglandin Dehydrogenases; Immunohistochemistry; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Synovial Membrane | 2012 |
Clinical significance of cartilage biomarkers for monitoring structural joint damage in rheumatoid arthritis patients treated with anti-TNF therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cartilage Oligomeric Matrix Protein; Cartilage, Articular; Collagen Type II; Drug Therapy, Combination; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Hyaluronic Acid; Infliximab; Joints; Male; Matrilin Proteins; Methotrexate; Middle Aged; Procollagen; Tumor Necrosis Factor-alpha | 2012 |
Semantically equivalent PubMed and Ovid-MEDLINE queries: different retrieval results because of database subset inclusion.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; PubMed; Randomized Controlled Trials as Topic | 2012 |
Effect of very early treatment in rheumatoid arthritis on bone oedema and synovitis, using magnetic resonance imaging.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases; Disease Progression; Early Diagnosis; Edema; Female; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Severity of Illness Index; Synovitis; Treatment Outcome; Wrist Joint | 2012 |
Evidence of the symptomatic and structural efficacy of methotrexate in daily practice as the first disease-modifying drug in rheumatoid arthritis despite its suboptimal use: results from the ESPOIR early synovitis cohort.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Health Status; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Severity of Illness Index; Synovitis; Treatment Outcome; Young Adult | 2012 |
Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases; Disease Progression; Edema; Female; Finger Joint; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Tacrolimus; Treatment Outcome; Wrist Joint | 2013 |
Serious adverse events-missing in action: comment on the article by Kremer et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Pyrimidines; Pyrroles | 2012 |
Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Fluorescent Antibody Technique; Genotype; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane; Young Adult | 2012 |
Is it time to optimize anchor therapy for rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Europe; Humans; Methotrexate; Practice Guidelines as Topic; Societies, Medical; Treatment Outcome | 2012 |
A commentary on TREAT: the trial of early aggressive drug therapy in juvenile idiopathic arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Clinical Trials as Topic; Etanercept; Humans; Immunoglobulin G; Joints; Methotrexate; Multicenter Studies as Topic; Receptors, Tumor Necrosis Factor; Secondary Prevention; Treatment Outcome | 2012 |
The time course of gastric methotrexate intolerance in patients with rheumatoid arthritis and psoriatic arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Retrospective Studies; Time Factors; Treatment Outcome; Vomiting | 2013 |
Differential gene expression profiles may differentiate responder and nonresponder patients with rheumatoid arthritis for methotrexate (MTX) monotherapy and MTX plus tumor necrosis factor inhibitor combined therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; HLA-DRB1 Chains; Humans; Infliximab; Male; Methotrexate; Middle Aged; Transcriptome; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Diseases; Chi-Square Distribution; Cyclin D1; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Risk Factors; Severity of Illness Index; Thymidylate Synthase; Young Adult | 2013 |
Nocardia neocaledoniensis [corrected] as a cause of skin and soft tissue infection.
Topics: Adenosine Triphosphatases; Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacterial Proteins; Bacteriological Techniques; DNA, Bacterial; DNA, Ribosomal; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Nocardia; Nocardia Infections; Prednisone; RNA, Ribosomal, 16S; SEC Translocation Channels; SecA Proteins; Sequence Analysis, DNA; Skin Diseases, Bacterial; Soft Tissue Infections | 2012 |
Vasculitis associated with tumor necrosis factor-α inhibitors.
Topics: Adalimumab; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Azathioprine; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Etanercept; Female; Glucocorticoids; Hematuria; Humans; Immunoglobulin G; Immunologic Factors; Infliximab; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Polyneuropathies; Prednisone; Proteinuria; Receptors, Tumor Necrosis Factor; Retrospective Studies; Rituximab; Tumor Necrosis Factor-alpha; Vasculitis; Young Adult | 2012 |
Immunomodulatory effect of sertraline in a rat model of rheumatoid arthritis.
Topics: Analysis of Variance; Animals; Arthritis, Rheumatoid; Concanavalin A; Cyclooxygenase 2; Cytokines; Cytotoxicity Tests, Immunologic; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Immunologic Factors; Methotrexate; Rats; Rats, Inbred Lew; Sertraline; Spleen; Thymidine | 2012 |
Rheumatoid factor determines structural progression of rheumatoid arthritis dependent and independent of disease activity.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cohort Studies; Cross-Sectional Studies; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Retrospective Studies; Rheumatoid Factor | 2013 |
Combined use of etanercept and MTX restores CD4⁺/CD8⁺ ratio and Tregs in spleen and thymus in collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-CD8 Ratio; Cytokines; Etanercept; Immunoglobulin G; Male; Methotrexate; Mice; Mice, Inbred DBA; RANK Ligand; Receptors, Tumor Necrosis Factor; Spleen; T-Lymphocyte Subsets; Thymus Gland | 2012 |
Long-term therapeutic effects and safety of tacrolimus added to methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2013 |
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; Cells, Cultured; Cilostazol; Cytokines; Disease Models, Animal; DNA Primers; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Male; Methotrexate; Mice; Mice, Inbred DBA; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles | 2012 |
Clinical remission following treatment with tumour necrosis factor-alpha antagonists is not accompanied by changes in asymmetric dimethylarginine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Epstein-Barr virus and methotrexate-related CNS lymphoma in a patient with rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Brain Neoplasms; Epstein-Barr Virus Infections; Female; Humans; Immunoconjugates; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Retreatment; Treatment Outcome | 2013 |
Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes; Prospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure.
Topics: Adult; AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Multienzyme Complexes; Nucleotide Deaminases; Precision Medicine; Pyrophosphatases; Treatment Outcome | 2012 |
Rhodococcus erythropolis encephalitis in patient receiving rituximab.
Topics: Actinomycetales Infections; Adult; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Immunosuppression Therapy; Meningoencephalitis; Methotrexate; Rhodococcus; Rituximab | 2012 |
Subcutaneous methotrexate to cut costs?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Care Costs; Humans; Infusions, Subcutaneous; Methotrexate; Retrospective Studies | 2012 |
[Liver diseases in rheumatoid and psoriatic arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Methotrexate; Middle Aged; Obesity; Risk Factors | 2012 |
HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multidrug hypersensitivity marker?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; HLA-A Antigens; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged | 2013 |
Impact of tocilizumab therapy on antibody response to influenza vaccine in patients with rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Hemagglutination Inhibition Tests; Humans; Immunocompromised Host; Influenza Vaccines; Influenza, Human; Methotrexate; Middle Aged; Predictive Value of Tests | 2012 |
Twenty-four-week clinical results of adalimumab therapy in Japanese patients with rheumatoid arthritis: retrospective analysis for the best use of adalimumab in daily practice.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Japan; Longitudinal Studies; Male; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2013 |
Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Prednisone; Radiography | 2012 |
Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Male; Methotrexate; Prednisone; Radiography | 2012 |
Rituximab dissociates the tight link between disease activity and joint damage in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Humans; Inflammation; Joints; Methotrexate; Radiography; Retrospective Studies; Rituximab | 2013 |
Serum soluble receptor for advanced glycation end products levels and aortic augmentation index in early rheumatoid arthritis--a prospective study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Carotid Artery Diseases; Carotid Intima-Media Thickness; Disease Progression; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Prospective Studies; Pulse Wave Analysis; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Treatment Outcome; Vascular Stiffness | 2013 |
Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.
Topics: Adenosine; ARNTL Transcription Factors; Arthritis, Rheumatoid; Cell Line; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Cryptochromes; Fatigue; Humans; Inflammation; Interleukin-1; Interleukin-10; Methotrexate; Monocytes; Period Circadian Proteins; Phenethylamines; Receptor, Adenosine A2A; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Reversible leukoencephalopathy after oral methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Female; Humans; Leukoencephalopathies; Methotrexate; Middle Aged | 2012 |
How much difference does the age at onset make in early arthritis patients? Comparison between the ACR 1987 and the ACR/EULAR 2010 classification criteria for rheumatoid arthritis at the time of diagnosis.
Topics: Adolescent; Adult; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Sensitivity and Specificity; Severity of Illness Index | 2013 |
Tumour necrosis factor-alpha inhibitor-induced hepatic injury in patients with rheumatoid arthritis: two case reports and an analysis of the laboratory data from the Slovenian national biologicals registry.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Registries; Slovenia; Sulfasalazine; Tumor Necrosis Factor-alpha | 2013 |
Coexistence of Epstein-Barr virus-associated lymphoproliferative disorder and marginal zone B-cell lymphoma of the thymus in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Transformation, Neoplastic; Comorbidity; Epstein-Barr Virus Infections; Humans; Lymphocytes; Lymphoma, B-Cell, Marginal Zone; Lymphoproliferative Disorders; Male; Methotrexate; Plasma Cells; Thymectomy; Thymus Neoplasms | 2012 |
Efficacy of adjunct tacrolimus treatment in patients with rheumatoid arthritis with inadequate responses to methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retreatment; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2013 |
Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisolone; Retreatment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Wrist Joint | 2013 |
Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients.
Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Japan; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2013 |
Yellow nail syndrome.
Topics: Aged; Arthritis, Rheumatoid; Chylous Ascites; Female; Follow-Up Studies; Humans; Lymphography; Methotrexate; Paracentesis; Rare Diseases; Risk Assessment; Severity of Illness Index; Tomography, X-Ray Computed; Yellow Nail Syndrome | 2012 |
Patients' access to biologics in rheumatoid arthritis: a comparison between Portugal and other European countries.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Europe; Health Expenditures; Health Services Accessibility; Humans; Methotrexate; Portugal; Socioeconomic Factors | 2013 |
Effects of shark cartilage polysaccharides on the secretion of IL-6 and IL-12 in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cartilage; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation Mediators; Interleukin-12; Interleukin-6; Joints; Macrophages, Peritoneal; Male; Methotrexate; Polysaccharides; Rats; Rats, Wistar; Sharks; Time Factors | 2012 |
[Single-photon emission computed tomography in the diagnosis of myocardial perfusion abnormalities in patients with rheumatoid arthritis: preliminary data].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Circulation; Cardiomyopathies; Female; Humans; Male; Methotrexate; Middle Aged; Nitriles; Pilot Projects; Tomography, Emission-Computed, Single-Photon; Young Adult | 2012 |
Determination of erythrocyte methotrexate polyglutamates by liquid chromatography/tandem mass spectrometry after low-dose methotrexate therapy in Chinese patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; China; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Stability; Erythrocytes; Humans; Linear Models; Liquid-Liquid Extraction; Methotrexate; Polyglutamic Acid; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Short time administration of antirheumatic drugs - methotrexate as a strong inhibitor of osteoblast's proliferation in vitro.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Remodeling; Cattle; Cell Division; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Immunohistochemistry; In Vitro Techniques; Methotrexate; Osteoblasts; Osteocalcin; Reference Values; Risk Assessment | 2012 |
Cutaneous leishmaniasis with histopathologic pattern of non-necrotizing granulomatous dermatitis in patients treated with adalimumab.
Topics: Adalimumab; Antibodies, Antinuclear; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Granuloma; Humans; Leishmaniasis, Cutaneous; Meglumine; Meglumine Antimoniate; Methotrexate; Middle Aged; Organometallic Compounds | 2012 |
Propensity-adjusted association of methotrexate with overall survival in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2013 |
Methotrexate saves lives: a pearl of observational research.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate | 2013 |
Treatment of early rheumatoid arthritis in a multinational inception cohort of Latin American patients: the GLADAR experience.
Topics: Adult; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Management; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Isoxazoles; Latin America; Leflunomide; Male; Methotrexate; Middle Aged; Registries; Sulfasalazine; Treatment Outcome | 2012 |
[Therapy of rheumatoid arthritis with methotrexate. Claims data analysis of treatment patterns].
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Germany; Humans; Insurance Claim Review; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prescriptions; Prevalence; Risk Factors; Treatment Outcome; Young Adult | 2012 |
[Regression of peripheral and pulmonary rheumatoid nodules under therapy with rituximab].
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug Therapy, Combination; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Retrospective Studies; Rheumatoid Factor; Rheumatoid Nodule; Rituximab; Treatment Outcome | 2013 |
Methodological aspects and the interpretation of clinical trial data: lessons from the TEAR trial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor | 2013 |
Hemorrhagic-acquired factor XIII deficiency associated with tocilizumab for treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Cyclosporine; Down-Regulation; Factor XIII; Factor XIII Deficiency; Fibrinogen; Hematoma; Humans; Immunosuppressive Agents; Interleukin-6; Male; Methotrexate; Methylprednisolone; Middle Aged; Postoperative Complications; Sjogren's Syndrome | 2012 |
Pharmacogenetic polymorphisms contributing to toxicity induced by methotrexate in the southern Spanish population with rheumatoid arthritis.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Spain; White People | 2012 |
Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prognosis; Registries; Remission Induction; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Elasticity Imaging Techniques; Female; Humans; Isoxazoles; Leflunomide; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Multivariate Analysis; Risk Factors | 2012 |
Reply: The effect of triple therapy versus etanercept plus methotrexate in rheumatoid arthritis: comment on the article by Moreland et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor | 2013 |
The effect of triple therapy versus etanercept plus methotrexate in rheumatoid arthritis: comment on the article by Moreland et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor | 2013 |
The use of continuous data versus binary data in MTC models: a case study in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Combined Modality Therapy; Decision Making; Europe; Evidence-Based Medicine; Humans; Methotrexate; Models, Statistical; Organizational Case Studies; Outcome Assessment, Health Care; Placebos; Randomized Controlled Trials as Topic; Severity of Illness Index; Societies, Medical; Surveys and Questionnaires | 2012 |
Genetic variation in the SLC19A1 gene and methotrexate toxicity in rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Cell Line; Female; Genetic Association Studies; Haplotypes; Humans; Linkage Disequilibrium; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein | 2012 |
Triple DMARD combination for rheumatoid arthritis resistant to methotrexate and steroid combination: a single-center experience.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 2013 |
[Anesthetic management of a patient with thrombocytopenia induced by methotrexate undergoing emergent clipping surgery].
Topics: Aged; Anesthesia, General; Arthritis, Rheumatoid; Emergencies; Female; Humans; Immunosuppressive Agents; Intracranial Aneurysm; Leucovorin; Methotrexate; Piperidines; Platelet Transfusion; Postoperative Care; Propofol; Remifentanil; Subarachnoid Hemorrhage; Thrombocytopenia; Treatment Outcome; Vascular Surgical Procedures | 2012 |
Matrix to predict rapid radiographic progression of early rheumatoid arthritis patients from the community treated with methotrexate or leflunomide: results from the ESPOIR cohort.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Cohort Studies; Disease Progression; Female; Humans; Isoxazoles; Leflunomide; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Peptides, Cyclic; Prognosis; Radiography | 2012 |
[Effects of sinomenine and methotrexate on fibroblast-like synoviocytes in rheumatoid arthritis].
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Methotrexate; Morphinans; Synovial Membrane | 2012 |
Adherence to a treat-to-target strategy in early rheumatoid arthritis: results of the DREAM remission induction cohort.
Topics: Abdominal Pain; Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Early Diagnosis; Etanercept; Female; Follow-Up Studies; Guideline Adherence; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Nausea; Netherlands; Outcome Assessment, Health Care; Practice Guidelines as Topic; Receptors, Tumor Necrosis Factor; Remission Induction; Severity of Illness Index; Sulfasalazine | 2012 |
Clinical outcome in patients with rheumatoid arthritis switched to tocilizumab after etanercept or infliximab failure.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Prednisolone; Receptors, Tumor Necrosis Factor; Retrospective Studies; Treatment Outcome | 2013 |
Raised circulating tenascin-C in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biomarkers; Blotting, Western; Cohort Studies; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infliximab; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Myositis; Sjogren's Syndrome; Spondylitis, Ankylosing; Tenascin; Treatment Outcome; Young Adult | 2012 |
Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Gold; Hyperthermia, Induced; Metal Nanoparticles; Methotrexate; Mice; Nanocapsules; Phototherapy; Treatment Outcome | 2013 |
[Rheumatoid arthritis: strategies for biotherapy].
Topics: Abatacept; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunoconjugates; Methotrexate; Tumor Necrosis Factor-alpha | 2012 |
[How early would we really administer biologics?].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Administration Schedule; Germany; Humans; Internationality; Methotrexate; Practice Guidelines as Topic; Rheumatology; Tumor Necrosis Factor-alpha | 2012 |
Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Prednisolone; Retrospective Studies; Risk Factors | 2013 |
[Rheumatoid arthritis: progress in diagnosis and treatment. Topics: IV. Treatment; 2. Antirheumatic agents, 1) non-biologic agents].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Female; Humans; Methotrexate; Sulfasalazine; Tacrolimus | 2012 |
Therapeutic efficacy and safety of methotrexate + leflunomide in Colombian patients with active rheumatoid arthritis refractory to conventional treatment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Child; Colombia; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult | 2012 |
Methotrexate-induced pseudotumor cerebri and psychosis in a case of rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pseudotumor Cerebri; Psychoses, Substance-Induced | 2012 |
Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Brain Mapping; Humans; Image Processing, Computer-Assisted; Joints; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Measuring methotrexate polyglutamates in red blood cells: a new LC-MS/MS-based method.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Drug Monitoring; Erythrocytes; Humans; Limit of Detection; Methotrexate; Polyglutamic Acid; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Tc-99 m diethylenetriamine-pentaacetic acid (DTPA): is it reliable for assessment of methotrexate-induced cumulative effect on renal filtration in rheumatoid arthritis patients?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Creatinine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Function Tests; Methotrexate; Middle Aged; Pentetic Acid; Reproducibility of Results; Technetium | 2013 |
Successful treatment of immunodeficiency-associated EBV-negative lymphoproliferative disorders in rheumatoid arthritis by methotrexate withdrawal and prevention of its relapse by rituximab administration.
Topics: Antibodies, Monoclonal, Murine-Derived; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Disease-Free Survival; Drug Administration Schedule; Herpesvirus 4, Human; Humans; Immunologic Deficiency Syndromes; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Recurrence; Rituximab | 2012 |
A predictive model for remission and low disease activity in patients with established rheumatoid arthritis receiving TNF blockers.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Prednisolone; Prospective Studies; Remission Induction; Rheumatoid Factor; Surveys and Questionnaires; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
Kinase inhibition in rheumatoid arthritis: a big advance?
Topics: Arthritis, Rheumatoid; Female; Humans; Janus Kinases; Male; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Tumor Necrosis Factor-alpha | 2013 |
Fibro-osseous pseudotumour of the digit in a patient with rheumatoid arthritis.
Topics: Amputation, Surgical; Arthritis, Rheumatoid; Biopsy, Needle; Bone Neoplasms; Disease Progression; Female; Fibroma, Ossifying; Fingers; Follow-Up Studies; Granuloma, Plasma Cell; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Rare Diseases; Treatment Outcome | 2013 |
Effects of 12 months of treatment with disease-modifying anti-rheumatic drugs on low and high density lipoprotein subclass distribution in patients with early rheumatoid arthritis: a pilot study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Prednisone | 2013 |
Functional disability can deteriorate despite suppression of disease activity in patients with rheumatoid arthritis: a large observational cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Disability Evaluation; Disease Progression; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Treatment Outcome | 2013 |
Clonal T-LGL population mimicking leukemia in Felty's syndrome--part of a continuous spectrum of T-LGL proliferations?
Topics: Adult; Aged; Arthralgia; Arthritis, Rheumatoid; Bone Marrow; Diagnosis, Differential; Exons; Felty Syndrome; Female; Gene Rearrangement, T-Lymphocyte; Humans; Immunophenotyping; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Sjogren's Syndrome; Splenomegaly; STAT3 Transcription Factor; T-Lymphocyte Subsets | 2013 |
The SMILE study -- safety of methotrexate in combination with leflunomide in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2013 |
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Longitudinal Studies; Lymphocytes; Male; Methotrexate; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Rituximab; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Rheumatoid arthritis: still a chronic disease.
Topics: Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2013 |
Inhibition of JNK in synovium by treatment with golimumab in rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Enzyme Activation; Female; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Male; Methotrexate; Middle Aged; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Synovial Membrane; Treatment Outcome | 2014 |
Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Sensitivity and Specificity; Synovitis; Ultrasonography | 2013 |
Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Male; Methotrexate; Opsonin Proteins; Phagocytosis; Pneumococcal Vaccines; Polysaccharides, Bacterial; Serotyping; Streptococcus pneumoniae | 2013 |
Compensated heart failure does not always alleviate overestimation of liver stiffness by transient elastography.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Elasticity Imaging Techniques; Female; Heart Failure; Humans; Liver; Liver Cirrhosis; Methotrexate; Predictive Value of Tests; Reproducibility of Results; Risk Factors; Treatment Outcome | 2013 |
Familial Mediterranean fever occurring in an elderly Japanese woman with recent-onset rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Colchicine; Cytoskeletal Proteins; Diagnostic Errors; Familial Mediterranean Fever; Female; Humans; Immunosuppressive Agents; Infliximab; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Mutation; Pyrin; Tumor Necrosis Factor-alpha | 2013 |
A biologic pharmacosurveillance program for rheumatoid arthritis: a single-center experience.
Topics: Adrenal Cortex Hormones; Alberta; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Registries; Remission Induction; Severity of Illness Index | 2013 |
Rare side effects of subcutaneous methotrexate therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Care Costs; Humans; Methotrexate | 2013 |
Creative trial design in RA: optimizing patient outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Methotrexate; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Research Design | 2013 |
Defining erosive disease typical of RA in the light of the ACR/EULAR 2010 criteria for rheumatoid arthritis; results of the data driven phase.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Diagnosis-Related Groups; Disease Progression; Europe; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Rheumatology; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome | 2013 |
A dancer with rheumatoid arthritis: a role for biologics.
Topics: Arthritis, Rheumatoid; Biological Products; Dancing; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Methotrexate; Treatment Outcome; Young Adult | 2013 |
Physician treatment preferences in rheumatoid arthritis of differing disease severity and activity: the impact of cost on first-line therapy.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Costs and Cost Analysis; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Pilot Projects; Practice Patterns, Physicians'; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Tumor Necrosis Factor-alpha | 2002 |
Increased thickness of the arterial intima-media detected by ultrasonography in patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arteriosclerosis; Arthritis, Rheumatoid; Carotid Artery Diseases; Carotid Artery, Common; Female; Femoral Artery; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Tunica Intima; Tunica Media; Ultrasonography | 2002 |
Folic acid and folinic acid supplementation during low-dose methotrexate therapy for rheumatoid arthritis: comment on the article by van Ede et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate | 2002 |
In utero first trimester exposure to low-dose methotrexate with increased fetal nuchal translucency and associated malformations.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Folic Acid; Gestational Age; Heart Septal Defects; Hernia, Diaphragmatic; Humans; Methotrexate; Neck; Pregnancy; Pregnancy Complications; Ultrasonography, Prenatal | 2002 |
Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-18; Methotrexate | 2002 |
Relapse of rheumatoid arthritis after substitution of oral for parenteral administration of methotrexate.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Recurrence | 2002 |
High levels of osteoprotegerin and soluble receptor activator of nuclear factor kappa B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor alpha treatment.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; Infliximab; Methotrexate; Middle Aged; Neoplasm Proteins; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Synovial Fluid; Tumor Necrosis Factor Decoy Receptors | 2002 |
Can very high-dose anti-tumor necrosis factor blockade at onset of rheumatoid arthritis produce long-term remission?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Pilot Projects; Remission Induction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2002 |
Detection and monitoring of methotrexate-associated lung injury using serum markers KL-6 and SP-D in rheumatoid arthritis.
Topics: Aged; Antigens; Antigens, Neoplasm; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Glucocorticoids; Glycoproteins; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Methylprednisolone; Middle Aged; Mucin-1; Mucins; Pulmonary Surfactant-Associated Protein D; Radiography, Thoracic; Tomography, X-Ray Computed; Treatment Outcome | 2002 |
Disseminated cryptococcal infection in rheumatoid arthritis treated with methotrexate and infliximab.
Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cryptococcosis; Cryptococcus neoformans; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fluconazole; Follow-Up Studies; Fungemia; Humans; Immunocompromised Host; Infliximab; Infusions, Intravenous; Male; Methotrexate; Risk Assessment; Severity of Illness Index; Tomography, X-Ray Computed | 2002 |
Multiple bilateral eyelid molluscum contagiosum lesions associated with TNFalpha-antibody and methotrexate therapy.
Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Eye Infections, Viral; Eyelid Diseases; Female; Humans; Infliximab; Methotrexate; Molluscum Contagiosum; Opportunistic Infections; Recurrence; Tumor Necrosis Factor-alpha; Warts | 2002 |
Pneumocystis carinii pneumonia following a second infusion of infliximab.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis; Radiography, Thoracic; Treatment Failure | 2002 |
Treatment of an edentulous patient with a dry mouth.
Topics: Adhesives; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dental Care for Chronically Ill; Denture Retention; Denture, Complete; Drug Interactions; Humans; Male; Methotrexate; Mouth, Edentulous; Patient Education as Topic; Prednisone; Salicylates; Xerostomia | 2000 |
Soluble HLA-DR levels in serum are associated with therapy and genetic factors in rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Epitopes; Female; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Solubility | 2002 |
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2002 |
Methotrexate, hydroxychloroquine, and intramuscular gold in rheumatoid arthritis: relative area under the curve effectiveness and sequence effects.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Disability Evaluation; Drug Administration Schedule; Health Status; Humans; Hydroxychloroquine; Injections, Intramuscular; Methotrexate; Organogold Compounds; Surveys and Questionnaires; Treatment Outcome | 2002 |
[Tubulointerstitial nephritis and uveitis (TINU syndrome) - comorbidity and complications in four patients].
Topics: Adolescent; Arthritis, Rheumatoid; Autoimmune Diseases; Child; Cyclosporine; Female; Follow-Up Studies; Humans; Male; Methotrexate; Mycophenolic Acid; Nephritis, Interstitial; Patient Care Team; Syndrome; Thyroiditis, Autoimmune; Treatment Outcome; Uveitis | 2002 |
Hodgkin's disease following methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Female; Hodgkin Disease; Humans; Methotrexate; Tomography, X-Ray Computed | 2002 |
Effects of antirheumatic therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Chi-Square Distribution; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lipids; Male; Methotrexate; Middle Aged; Probability; Prospective Studies; Sensitivity and Specificity; Severity of Illness Index; Triglycerides | 2002 |
Effect of methotrexate on pulmonary function in patients with rheumatoid arthritis--a prospective study.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Lung; Male; Methotrexate; Probability; Prospective Studies; Reference Values; Respiratory Function Tests; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2002 |
[2 years data of controlled trials with leflunomide vs. methotrexate and leflunomide vs. sulfasalazine].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2002 |
[Alcohol and patients with gout].
Topics: Alcohol Drinking; Antirheumatic Agents; Arthritis, Gouty; Arthritis, Rheumatoid; Contraindications; Drug Information Services; Drug Interactions; Humans; Methotrexate; Patient Education as Topic | 2002 |
Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Antigens, CD; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Italy; Male; Methotrexate; Middle Aged; Odds Ratio; Pharmacogenetics; Polymorphism, Genetic; Prednisone; Probability; Prognosis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reference Values; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex; Sex Distribution; Treatment Outcome | 2002 |
Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice.
Topics: Acetamides; Animals; Antibodies, Blocking; Antirheumatic Agents; Arthritis, Rheumatoid; Benzodiazepinones; Blotting, Western; Cell Line; Chondrocytes; GABA-A Receptor Antagonists; Hindlimb; Indoles; Isoquinolines; Joints; Ligands; Male; Methotrexate; Mice; Mice, Inbred MRL lpr; Microscopy, Confocal; Receptors, GABA-A; Synovial Membrane | 2002 |
Long-term remission of an EBV-positive B cell lymphoproliferative disorder associated with rheumatoid arthritis under methotrexate with anti-CD20 monoclonal antibody (Rituximab) monotherapy.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; B-Lymphocytes; Female; Herpesvirus 4, Human; Humans; Immunohistochemistry; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate; Remission Induction; Rituximab | 2002 |
[Methotrexate-induced pneumonitis in rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pneumonia | 2002 |
The methotrexate therapeutic response in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate; Research Design; Survival Analysis | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bias; Data Interpretation, Statistical; Humans; Methotrexate; Mortality; Proportional Hazards Models; Research Design | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Humans; Methotrexate; Proportional Hazards Models; Research Design; Sensitivity and Specificity | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; France; Humans; Lymphoma; Methotrexate; Prevalence; Prospective Studies; Risk Factors; Time Factors | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Antiphospholipid Syndrome; Antirheumatic Agents; Arteriosclerosis; Arthritis, Rheumatoid; Humans; Methotrexate; Research Design; Risk Factors | 2002 |
Radiographic healing with sustained clinical remission in a patient with rheumatoid arthritis receiving methotrexate monotherapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Regeneration; Female; Humans; Metacarpophalangeal Joint; Metatarsophalangeal Joint; Methotrexate; Middle Aged; Radiography; Remission Induction; Wrist Joint | 2002 |
Estimating the cost-effectiveness of 54 weeks of infliximab for rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Markov Chains; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Time Factors; Treatment Outcome | 2002 |
Remission of lymphoma after drug withdrawal in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Buttocks; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Muscle Neoplasms; Muscle, Skeletal; Remission, Spontaneous | 2002 |
[Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs].
Topics: Adult; Anorexia; Antirheumatic Agents; Arthritis, Rheumatoid; Exanthema; Female; Gastrointestinal Diseases; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Nausea; Penicillamine; Phytotherapy; Plant Preparations; Retrospective Studies; Sinomenium; Sulfasalazine | 2002 |
Summaries for patients. Combination therapy for rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Arthritis, Rheumatoid; Diarrhea; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Liver Function Tests; Male; Methotrexate; Middle Aged; Treatment Outcome | 2002 |
Purine enzymes in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adenosine Deaminase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Female; Folic Acid; Humans; Hypoxanthine Phosphoribosyltransferase; Leucovorin; Male; Methotrexate; Middle Aged; Nucleotidases; Purine-Nucleoside Phosphorylase; Purines; Regression Analysis | 2002 |
Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Private Practice; United States | 2002 |
Use of prognostic markets to guide biologic therapies for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Therapy; Biomarkers; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Infliximab; Methotrexate; Rheumatology | 2002 |
The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses.
Topics: Acute Disease; Aged; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Clinical Protocols; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Sulfasalazine; Treatment Outcome | 2002 |
[The effect of comedication with folic or folinic acid on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a randomized, double blind, placebo controlled study of 48 weeks].
Topics: Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 2002 |
[Diagnosis and treatment of rheumatoid arthritis].
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclosporins; Diagnosis, Differential; Exercise Therapy; Female; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prognosis; Radiography; Rheumatoid Factor; Sulfasalazine | 2002 |
Light and electron microscopic analysis of liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Microscopy, Electron; Middle Aged; Reference Values | 2002 |
[Etanercept--infliximab switch in rheumatoid arthritis 14 out of 131 patients treated with anti TNFalpha].
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Time Factors | 2002 |
Treatment of experimental adjuvant arthritis with the combination of methotrexate and lyophilized Enterococcus faecium enriched with organic selenium.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Density; Drug Therapy, Combination; Enterococcus faecium; Foot; Male; Methotrexate; Nitrates; Nitrites; Probiotics; Rats; Rats, Inbred Lew; Selenium; Treatment Outcome | 2002 |
Pancytopenia associated with leflunomide and methotrexate.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Middle Aged; Pancytopenia | 2003 |
Pretreatment cytokine profiles of peripheral blood mononuclear cells and serum from patients with rheumatoid arthritis in different american college of rheumatology response groups to methotrexate.
Topics: Adult; Aged; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cells, Cultured; Cohort Studies; Disease Progression; Etanercept; Female; Humans; Immunoglobulin G; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 2003 |
Life-threatening reversible bone marrow toxicity in a rheumatoid arthritis patient switched from leflunomide to infliximab.
Topics: Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Pancytopenia; Steroids | 2003 |
[Pharmacogenetics of disease modifying anti-rheumatic drugs].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arylamine N-Acetyltransferase; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pharmacogenetics; Polymorphism, Genetic; Sulfasalazine | 2002 |
[Lung involvements of RA, diagnosis and treatment].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiolitis Obliterans; Cryptogenic Organizing Pneumonia; Humans; Lung Diseases; Methotrexate; Pleural Diseases; Prognosis; Pulmonary Fibrosis; Rheumatic Nodule | 2002 |
Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Methotrexate; Middle Aged; Pneumonia | 2002 |
Unproven hypothesis that leflunomide is better than methotrexate as measured by magnetic resonance imaging: comment on the article by Reece et al.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Magnetic Resonance Imaging; Methotrexate | 2003 |
Prevalence of dermatophytosis in patients with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Adult; Age Distribution; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Comorbidity; Confidence Intervals; Dermatomycoses; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Prevalence; Probability; Prospective Studies; Reference Values; Risk Assessment; Sex Distribution | 2003 |
Low dose methotrexate and bone marrow suppression.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Diseases; Fatal Outcome; Female; Humans; Male; Medication Errors; Methotrexate | 2003 |
The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice patterns and pregnancy outcomes.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Data Collection; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Receptors, Tumor Necrosis Factor; Risk Factors | 2003 |
Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Caffeine; Coffee; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Phosphodiesterase Inhibitors | 2003 |
[Evidence-based treatment of methotrexate-resistant rheumatoid arthritis. Combinations of conventional disease-modifying antirheumatic agents].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Placebos; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors | 2003 |
The cost-effectiveness of infliximab (Remicade) in the treatment of rheumatoid arthritis in Sweden and the United Kingdom based on the ATTRACT study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disease Progression; Drug Costs; Drug Therapy, Combination; Female; Follow-Up Studies; Health Care Costs; Humans; Infliximab; Male; Markov Chains; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Sweden; United Kingdom | 2003 |
[The rheumatologist's conflict between "off-label" prescription and failure to render assistance].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disease Progression; Drug Approval; Drug Costs; Drug Therapy, Combination; Ethics, Medical; Germany; Humans; Immunosuppressive Agents; Insurance Coverage; Insurance, Pharmaceutical Services; Male; Methotrexate; Middle Aged; Mycophenolic Acid; National Health Programs; Refusal to Treat; Treatment Outcome | 2003 |
Dosage and mode of administration of methotrexate in clinical trials: comment on the article by Genovese et al.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disability Evaluation; Dose-Response Relationship, Drug; Etanercept; Humans; Immunoglobulin G; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Severity of Illness Index | 2003 |
[Effect of bizhongxiao decoction on the expression of VEGF in the synovial membrane of C II-induced rheumatoid arthritis in rats].
Topics: Animals; Arthritis, Rheumatoid; Collagen Type II; Drugs, Chinese Herbal; Endothelial Growth Factors; Female; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Lymphokines; Male; Methotrexate; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Synovial Membrane; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Cutaneous ulceration with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate; Psoriasis; Ulcer | 2003 |
A weekly dosage taken daily.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Drug Overdose; Fatal Outcome; Female; Humans; Medication Errors; Methotrexate | 2003 |
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Genotype; Humans; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Promoter Regions, Genetic; Thymidylate Synthase | 2003 |
Methotrexate is the leading DMARD in Finland.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Finland; Humans; Hydroxychloroquine; Insurance, Health; Methotrexate; Rheumatic Diseases; Sulfasalazine | 2003 |
Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis.
Topics: Albumins; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Drug Carriers; Drug Delivery Systems; Fibroblasts; Humans; Lasers; Male; Methotrexate; Mice; Mice, Inbred DBA; Mice, SCID; Microscopy, Confocal; Microscopy, Fluorescence; Optics and Photonics; Pentetic Acid; Serum Albumin; Synovial Membrane | 2003 |
Termination of disease-modifying antirheumatic drugs in rheumatoid arthritis and in psoriatic arthritis. A comparative study of 270 cases.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gold Sodium Thiomalate; Humans; Life Tables; Long-Term Care; Male; Methotrexate; Middle Aged; Regression Analysis; Retrospective Studies; Sulfasalazine; Treatment Outcome | 2003 |
Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Cyclosporine; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 2003 |
The prevalence of patients with rheumatoid arthritis in the West Midlands fulfilling the BSR criteria for anti-tumour necrosis factor therapy: an out-patient study.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Glucocorticoids; Guideline Adherence; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Outpatient Clinics, Hospital; Patient Selection; Prednisolone; Prevalence; Receptors, Tumor Necrosis Factor; Rheumatology; Treatment Failure; Tumor Necrosis Factor-alpha | 2003 |
The responsiveness of generic health status measures as assessed in patients with rheumatoid arthritis receiving infliximab.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Health Status Indicators; Humans; Infliximab; Methotrexate; Quality of Life; Reproducibility of Results; Surveys and Questionnaires | 2003 |
In vitro growth rate of fibroblast-like synovial cells is reduced by methotrexate treatment.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Biopsy, Needle; Cell Division; Cells, Cultured; Female; Fibroblasts; Humans; Male; Methotrexate; Middle Aged; Synovial Membrane; Time Factors | 2003 |
Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with RA?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Humans; Methotrexate; Middle Aged; Statistics, Nonparametric | 2003 |
Chronic pulmonary toxicity of methotrexate and rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Male; Methotrexate; Middle Aged; Pulmonary Fibrosis | 2003 |
Mitral valve surgery in a patient with rheumatoid arthritis being treated with methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiopulmonary Bypass; Humans; Methotrexate; Mitral Valve; Mitral Valve Insufficiency; Mitral Valve Prolapse | 2003 |
Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Folic Acid; Humans; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Monocytes; T-Lymphocytes | 2003 |
Pausing paw proliferation.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Joints; Methotrexate; Mice | 2003 |
Effect of methotrexate on male fertility.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Infertility, Male; Male; Methotrexate | 2003 |
Add-on or step-up trials for new drug development in rheumatoid arthritis: a new standard?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Decision Making; Drug Therapy, Combination; Drugs, Investigational; Humans; Methotrexate; Research Design | 2003 |
Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Arthroscopy; Biomarkers; Blood Sedimentation; C-Reactive Protein; Calgranulin A; Calgranulin B; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Knee Joint; Methotrexate; Radiography; Serum Amyloid A Protein; Severity of Illness Index; Spondylitis, Ankylosing; Synovial Fluid; Synovial Membrane | 2003 |
Methotrexate-induced pulmonary lymphoma.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Carcinogens; Humans; Lung Neoplasms; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged | 2003 |
The induction of apoptosis by methotrexate in activated lymphocytes as indicated by fluorescence hyperpolarization: a possible model for predicting methotrexate therapy for rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Drug Resistance; Female; Fluoresceins; Fluorescence Polarization; Fluorescence Polarization Immunoassay; Fluorometry; Humans; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Middle Aged; Models, Biological; Predictive Value of Tests; Reaction Time; Reproducibility of Results | 2003 |
Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis.
Topics: Acute Disease; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Female; Finger Joint; Foot Joints; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Radiography; Rheumatoid Factor; Time Factors | 2003 |
Factors influencing uptake of influenza vaccination in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Guideline Adherence; Humans; Immunosuppressive Agents; Influenza Vaccines; Male; Methotrexate; Middle Aged; Patient Acceptance of Health Care | 2003 |
Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Virus Activation | 2003 |
Generation of three-dimensional pannus-like tissues in vitro from single cell suspensions of synovial fluid cells from arthritis patients.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Cell Death; Cell Differentiation; Cells, Cultured; Connective Tissue Cells; Culture Techniques; Cytokines; Fibroblasts; Histocompatibility Antigens Class II; Humans; Immunosuppressive Agents; Macrophages; Methotrexate; Synovial Membrane | 2004 |
[Can a combination therapy with leflunomide be recommended for patients with active rheumatoid arthritis?].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate; Treatment Outcome | 2003 |
Suppressive effect of combination treatment of leflunomide and methotrexate on chemokine expression in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemokine CCL17; Chemokine CCL2; Chemokine CCL22; Chemokines; Chemokines, CC; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Statistics, Nonparametric | 2003 |
[Rare opportunistic disease in a patient treated with immunosuppressive therapy for rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Bone Marrow; Humans; Immunocompromised Host; Immunosuppressive Agents; Leishmaniasis, Visceral; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pregnenediones | 2003 |
[Use of monoclonal antibodies to tumor necrosis factor (remicade) in rheumatoid arthritis: preliminary results].
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Female; Humans; Infliximab; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Pilot Projects; Time Factors | 2003 |
Peritoneal tuberculosis mimicking advanced ovarian cancer in a patient treated with methotrexate for chronic rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Mycobacterium tuberculosis; Needlestick Injuries; Ovarian Neoplasms; Peritonitis, Tuberculous; Tomography, X-Ray Computed | 2003 |
Parenteral methotrexate should be given before biological therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Immunotherapy; Injections, Intravenous; Methotrexate; Middle Aged; Prospective Studies | 2003 |
Methotrexate pneumonitis in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pneumonia | 2003 |
Comment on methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Female; Humans; Infliximab; Methotrexate; Pneumonia | 2003 |
Methotrexate, hydroxychloroquine, and intramuscular gold in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Organogold Compounds | 2003 |
Toward a definition and method of assessment of treatment failure and treatment effectiveness: the case of leflunomide versus methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Patient Satisfaction; Predictive Value of Tests; Severity of Illness Index; Surveys and Questionnaires; Treatment Failure | 2003 |
A survey of British rheumatologists' DMARD preferences for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Choice Behavior; Consultants; Drug Prescriptions; Drug Therapy, Combination; Health Care Surveys; Humans; Methotrexate; Prognosis; Sulfasalazine; Surveys and Questionnaires; United Kingdom | 2004 |
Myelotoxicity due to methotrexate - an iatrogenic cause.
Topics: Aged; Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Iatrogenic Disease; Methotrexate; Middle Aged; Trimethoprim | 2003 |
Cytomegalovirus infection in a patient with rheumatoid arthritis.
Topics: Anemia, Aplastic; Antiviral Agents; Arthritis, Rheumatoid; Cyclosporine; Cytomegalovirus; Cytomegalovirus Infections; Female; Ganciclovir; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Middle Aged; Pneumonia, Viral; RNA, Viral; Treatment Outcome | 2003 |
Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity.
Topics: Acetylcholine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Pressure; Endothelium, Vascular; Etanercept; Female; Forearm; Heart Rate; Homocysteine; Humans; Immunoglobulin G; Methotrexate; Nitroglycerin; Receptors, Tumor Necrosis Factor; Regional Blood Flow; Severity of Illness Index; Time; Treatment Outcome; Vasodilation; Vasodilator Agents; Women's Health | 2003 |
Therapeutic benefits of irsogladine maleate on aphthous stomatitis induced by methotrexate in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Risk Assessment; Stomatitis, Aphthous; Treatment Outcome; Triazines | 2003 |
Survival and effectiveness of leflunomide compared with methotrexate and sulfasalazine in rheumatoid arthritis: a matched observational study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Chi-Square Distribution; Databases, Factual; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Statistics, Nonparametric; Sulfasalazine; Time Factors; Treatment Failure | 2003 |
Remission of methotrexate-resistant rheumatoid arthritis after receiving 5-fluorouracil for colon cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Colonic Neoplasms; Drug Resistance; Fluorouracil; Humans; Male; Methotrexate; Remission Induction | 2003 |
METHOTREXATE IN THE MANAGEMENT OF SEVERE PSORIASIS AND ARTHRITIS: REPORT OF A CASE.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Arthritis; Arthritis, Rheumatoid; Drug Therapy; Methotrexate; Psoriasis; Toxicology | 1964 |
METABOLIC STUDIES OF THE EFFECTS OF METHOTREXATE.
Topics: Arthritis; Arthritis, Rheumatoid; Blood; Brain Neoplasms; Breast Neoplasms; Calcium; Calcium, Dietary; Diet; Drug Therapy; Feces; Humans; Hypercalcemia; Lung Neoplasms; Methotrexate; Natriuresis; Pharmacology; Phosphorus; Potassium; Sodium; Sodium, Dietary; Urine | 1965 |
[REMARKS ON THE USE OF SMALL INTERMITTENT DOSES OF AN ANTIFOLIC AGENT AMETHOPTERIN IN PSORIATIC RHEUMATISM AND OF NITROGEN MUSTARD IN CHRONIC PROTOTYPIC RHEUMATISM (C.E.P.)].
Topics: Arthritis; Arthritis, Rheumatoid; Drug Therapy; Folic Acid Antagonists; Humans; Mechlorethamine; Methotrexate; Psoriasis; Rheumatic Diseases | 1965 |
HPLC determination of erythrocyte methotrexate polyglutamates after low-dose methotrexate therapy in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Calibration; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Methotrexate; Monitoring, Physiologic; Polyglutamic Acid; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Acute secondary gastrointestinal amyloidosis in a patient with rheumatoid arthritis.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Amyloidosis; Arthritis, Rheumatoid; Congo Red; Female; Gastrointestinal Diseases; Humans; Immunosuppressive Agents; Methotrexate; Recurrence; Time Factors | 2003 |
Normalization of methotrexate-induced high levels of serum transaminases after ursodeoxycholic acid administration in a rheumatoid arthritis patient.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Transaminases; Ursodeoxycholic Acid | 2003 |
[Idiopathic hypereosinophilic syndrome associated with rheumatoid arthritis. A case report].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Cyclosporine; Female; Glucocorticoids; Humans; Hypereosinophilic Syndrome; Immunosuppressive Agents; Methotrexate; Middle Aged; Sulfasalazine | 2003 |
Correlation between HRCT findings, pulmonary function tests and bronchoalveolar lavage cytology in interstitial lung disease associated with rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Lung; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Respiratory Function Tests; Statistics as Topic; Tomography, Spiral Computed | 2004 |
Monitoring by rheumatologists for methotrexate-, etanercept-, infliximab-, and anakinra-associated adverse events.
Topics: Adverse Drug Reaction Reporting Systems; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Data Collection; Etanercept; Humans; Immunoglobulin G; Infliximab; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Practice Guidelines as Topic; Receptors, Tumor Necrosis Factor; Rheumatology; Sialoglycoproteins | 2003 |
Methotrexate-induced pulmonary injury: serial CT findings.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Lung; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Pneumonia; Retrospective Studies; Time Factors; Tomography, X-Ray Computed | 2003 |
Treatment compliance and dosage administration among rheumatoid arthritis patients receiving infliximab, etanercept, or methotrexate.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Costs; Etanercept; Female; Guideline Adherence; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; United States | 2003 |
Cyclosporin A in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate | 2003 |
Cyclosporin and methotrexate therapy.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Sulfasalazine | 2003 |
Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Empyema; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Pneumonia; Radiography, Thoracic; Tomography, X-Ray Computed | 2004 |
[Innovative technologies in the complex treatment of patients with rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Prednisolone; Recurrence; Stem Cell Transplantation; Time Factors; Treatment Outcome; Vincristine | 2003 |
Disseminated tuberculosis, pulmonary aspergillosis and cutaneous herpes simplex infection in a patient with infliximab and methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Aspergillosis, Allergic Bronchopulmonary; Female; Herpes Simplex; Humans; Infliximab; Methotrexate; Middle Aged; Tuberculosis | 2003 |
Comparison of rheumatoid arthritis clinical trial outcome measures: a simulation study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Clinical Trials as Topic; Computer Simulation; Cyclooxygenase Inhibitors; Female; Humans; Lactones; Male; Methotrexate; Middle Aged; Models, Statistical; Sensitivity and Specificity; Severity of Illness Index; Sulfones; Treatment Outcome | 2003 |
Lack of evidence for inhibition of angiogenesis as a central mechanism of the antiarthritic effect of methotrexate.
Topics: Angiogenesis Inhibitors; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; In Vitro Techniques; Methotrexate; Mice; Neovascularization, Pathologic; Placenta | 2005 |
Quadriparesis in a young female suffering from rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cervical Vertebrae; Chloroquine; Cyclooxygenase Inhibitors; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Pyrazoles; Quadriplegia; Radiography; Sulfonamides; Treatment Failure | 2003 |
Plasma from rheumatoid patients taking low dose methotrexate enhances platelet aggregation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Methotrexate; Platelet Aggregation | 2002 |
Medical resource use and costs among rheumatoid arthritis patients receiving disease-modifying antirheumatic drug therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Direct Service Costs; Drug Costs; Drug Therapy, Combination; Female; Health Care Costs; Health Resources; Health Services Research; Humans; Hydroxychloroquine; Male; Managed Care Programs; Methotrexate; Middle Aged; Midwestern United States; New England; Sulfasalazine; Time Factors; Treatment Outcome | 2000 |
Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Drug Interactions; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Models, Biological | 2003 |
High incidence of hepatotoxicity of isoniazid treatment for tuberculosis chemoprophylaxis in patients with rheumatoid arthritis treated with methotrexate or sulfasalazine and anti-tumour necrosis factor inhibitors.
Topics: Adult; Aged; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoniazid; Methotrexate; Middle Aged; Sulfasalazine; Tuberculosis; Tumor Necrosis Factor-alpha | 2003 |
Methotrexate for rheumatoid arthritis: what should the patient be told?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Patient Education as Topic | 2003 |
[New strategies against autoaggressive immune system. Is rheumatism to be healable soon?].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroscopy; Cells, Cultured; Chondrocytes; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Infliximab; Lupus Erythematosus, Systemic; Methotrexate; Rheumatic Diseases; Scleroderma, Systemic; Stem Cell Transplantation; Tumor Necrosis Factor-alpha | 2003 |
The impact of escalating conventional therapy in rheumatoid arthritis patients referred for anti-tumour necrosis factor-alpha therapy.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Costs; Female; Humans; Male; Methotrexate; Middle Aged; Patient Selection; Practice Guidelines as Topic; Prospective Studies; Quality of Life; Treatment Failure; Tumor Necrosis Factor-alpha | 2004 |
Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor.
Topics: Aged; Anemia, Aplastic; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2003 |
Evaluating changes in health status: sensitivity to change of the modified Arabic Health Assessment Questionnaire in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Cultural Comparison; Egypt; Female; Health Status; Health Status Indicators; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Recovery of Function; Sensitivity and Specificity; Surveys and Questionnaires; United States | 2003 |
Hepatitis C and methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cohort Studies; Female; Guideline Adherence; Hepatitis C; Hospitals, University; Hospitals, Veterans; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Retrospective Studies | 2003 |
Longterm observational study of methotrexate use in a Dutch cohort of 1022 patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Folic Acid; Humans; Life Tables; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Physicians; Prednisolone; Proportional Hazards Models; Retrospective Studies; Rheumatology; Sulfasalazine; Survival Analysis | 2003 |
[Experiences with infliximab in the treatment of active rheumatoid arthritis and spondyloarthropathy].
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Middle Aged; Spondylarthropathies; Treatment Outcome | 2003 |
Etanercept versus etanercept plus methotrexate: a registry-based study suggesting that the combination is clinically more efficacious.
Topics: Arthritis, Rheumatoid; Cohort Studies; Drug Evaluation; Drug Therapy, Combination; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Immunosuppressive Agents; Longitudinal Studies; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Registries; Severity of Illness Index; Sweden; Treatment Outcome; Tumor Necrosis Factor-alpha | 2003 |
[Renal tubular dysfunction in patients with rheumatoid arthritis starting with low dose of methotrexate].
Topics: Acetylglucosaminidase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Kidney Tubules; Male; Methotrexate; Middle Aged | 2003 |
Effective anti-viral therapy for hemophagocytic syndrome associated with B-cell lymphoma.
Topics: Acyclovir; Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Histiocytosis, Non-Langerhans-Cell; Humans; Lymphoma, B-Cell; Methotrexate; Syndrome | 2003 |
Intractable pain in a rheumatoid wrist.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Pain, Intractable; Prednisone; Synovial Cyst; Tenosynovitis; Treatment Outcome; Wrist; Wrist Joint | 2003 |
Secondary addition of methotrexate to partial responders to etanercept alone is effective in severe rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemotherapy, Adjuvant; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor | 2004 |
Myelodysplastic syndrome associated with low-dose methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Bone Marrow Cells; Female; Humans; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Pancytopenia | 2004 |
Mortality in rheumatoid arthritis patients treated with or without methotrexate.
Topics: Actuarial Analysis; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Insurance, Life; Male; Methotrexate; Middle Aged; United States | 2003 |
Subtherapeutic dosing of methotrexate in rheumatoid arthritis trials.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Pilot Projects; Risk Assessment; Treatment Outcome | 2004 |
Disease-modifying antirheumatic drugs: enhancing efficacy by combination.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Malignant lymphoma associated with rheumatoid arthritis, developing shortly after initiation of oral methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Male; Mandibular Neoplasms; Methotrexate; Middle Aged; Prednisolone; Vincristine | 2004 |
Patient preferences for treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Computer Simulation; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Organogold Compounds; Patient Satisfaction; Receptors, Tumor Necrosis Factor; Risk | 2004 |
Ten-year radiographic outcome in patients with rheumatoid factor positive rheumatoid arthritis treated with aggressive immunosuppressive combination therapy.
Topics: Administration, Oral; Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Methotrexate; Methylprednisolone; Middle Aged; Mycophenolic Acid; Prospective Studies; Pulse Therapy, Drug; Radiography; Remission Induction; Rheumatoid Factor; Treatment Outcome | 2004 |
Activation dependent apoptosis of peripheral blood mononuclear cells from patients with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Humans; Leukocytes, Mononuclear; Methotrexate; Middle Aged | 2004 |
Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biological Availability; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged | 2004 |
Estimated prediagnosis radiological progression: an important tool for studying the effects of early disease modifying antirheumatic drug treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Disease Progression; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Radiography; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2005 |
Parenteral methotrexate should be given before biological therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Injections, Intravenous; Methotrexate | 2004 |
Two RA drugs better than one.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 2004 |
Anakinra: new preparation. Weakly effective in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Receptors, Interleukin-1; Sialoglycoproteins | 2004 |
Etanercept and methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Hematologic Diseases; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins | 2004 |
Etanercept and methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Fatigue Syndrome, Chronic; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Stress, Psychological | 2004 |
Right on target: coupling methotrexate to albumin to treat rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Carriers; Drug Combinations; Drug Synergism; Humans; Methotrexate; Serum Albumin | 2004 |
Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Incidence; Infliximab; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Risk Factors; SEER Program; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2004 |
Methotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo.
Topics: Albumins; Animals; Arthritis, Rheumatoid; Cartilage; Cell Movement; Drug Therapy, Combination; Female; Fibroblasts; Humans; Immunosuppressive Agents; Methotrexate; Mice; Mice, SCID; Models, Animal; Serum Albumin; Synovial Membrane | 2004 |
Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX.
Topics: Animals; Antibodies; Antigens, CD; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Collagen Type II; Disease Models, Animal; Drug Administration Schedule; Drug Carriers; Drug Combinations; Drug Synergism; Flow Cytometry; Humans; Injections, Intravenous; Leukocytes, Mononuclear; Male; Methotrexate; Mice; Mice, Inbred DBA; Serum Albumin; Treatment Outcome | 2004 |
Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Etidronic Acid; Female; Humans; Kynurenine; Methotrexate; Neopterin; Osteoporosis; Prednisolone; Raloxifene Hydrochloride; Receptors, Glutamate; Tryptophan | 2003 |
Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Female; Follow-Up Studies; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Risk Assessment; Treatment Failure | 2005 |
Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Black or African American; Confidence Intervals; Europe; Female; Gene Expression Profiling; Gene Frequency; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; White People | 2004 |
Kineret: efficacy and safety in daily clinical practice: an interim analysis of the Kineret response assessment initiative (kreative) protocol.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 2003 |
Two is better than one? Combination therapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Treatment Outcome | 2004 |
Effect of low dose methotrexate on bone density in women with rheumatoid arthritis: results from a multicenter cross-sectional study.
Topics: Absorptiometry, Photon; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Cross-Sectional Studies; Female; Humans; Methotrexate; Middle Aged; Osteoporosis; Sex Factors | 2004 |
Giant cell arteritis in a patient taking etanercept and methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Giant Cell Arteritis; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 2004 |
[Markov model of decision making for basic therapy of rheumatoid arthritis: oder of monotherapy and expenses for drug therapy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Making; Humans; Markov Chains; Methotrexate; Organogold Compounds; Sulfasalazine | 2004 |
IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cytokines; Fibroblasts; Humans; Interleukin-15; Methotrexate; Synovial Membrane; T-Lymphocyte Subsets; T-Lymphocytes | 2004 |
[A case of pneumocystis carinii pneumonia associated with low dose methotrexate treatment for rheumatoid arthritis and trimethoprim-sulphamethoxazole induced pancytopenia].
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Pneumonia, Pneumocystis; Pulse Therapy, Drug; Trimethoprim, Sulfamethoxazole Drug Combination | 2004 |
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Membrane Transport Modulators; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; Sulfasalazine | 2004 |
Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung; Methotrexate; Pneumonia; Radiography | 2004 |
Methotrexate and folic acid: what is the optimal combination?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate | 2004 |
Septic arthritis caused by Actinobacillus ureae in a patient with rheumatoid arthritis receiving anti-tumor necrosis factor-alpha therapy.
Topics: Abscess; Actinobacillus Infections; Arthritis, Infectious; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Forearm; Humans; Immunoglobulin G; Immunosuppressive Agents; Knee Joint; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2004 |
Disseminated histoplasmosis presenting as pancytopenia in a methotrexate-treated patient.
Topics: Aged; Arthritis, Rheumatoid; Diagnosis, Differential; Histoplasma; Histoplasmosis; Humans; Male; Methotrexate; Opportunistic Infections; Pancytopenia; Prednisone | 2004 |
[Diagnosis and treatment of rheumatoid arthritis should be stardarized].
Topics: Arthritis, Rheumatoid; Autoantibodies; Diagnosis, Differential; Humans; Methotrexate; Practice Guidelines as Topic; Primary Health Care | 2004 |
[Methotrexate combined with leflunomide or hydroxychloroquine in the treatment of rheumatoid arteritis].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged | 2004 |
Pregnancy in a rheumatoid arthritis patient on infliximab and methotrexate.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infliximab; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2004 |
New drugs for rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Meta-Analysis as Topic; Methotrexate; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2004 |
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Collagen; Disease Models, Animal; Endopeptidases; Fluorescence; Histocytochemistry; Male; Methotrexate; Mice; Mice, Inbred DBA; Sensitivity and Specificity; Treatment Outcome | 2004 |
Monitoring guidelines for methotrexate-treated rheumatoid arthritis patients: comment on the article by Yazici et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Monitoring, Physiologic; Practice Guidelines as Topic | 2004 |
Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Leukemia, Erythroblastic, Acute; Methotrexate; Treatment Outcome | 2005 |
Risk factors for methotrexate-induced abnormal laboratory monitoring results in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cohort Studies; Female; Folic Acid; Humans; Hyperlipidemias; Incidence; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors | 2004 |
Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cross-Sectional Studies; Drug Resistance; Female; Humans; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Prognosis; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Treatment Outcome | 2005 |
Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Fibroblasts; Immunosuppressive Agents; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID | 2005 |
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2004 |
Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2004 |
Monitoring methotrexate therapy in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Monitoring; Half-Life; Hematopoiesis; Humans; Kidney; Liver; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 2004 |
Declines in mortality from acute myocardial infarction in successive incidence and birth cohorts of patients with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Case Management; Cohort Studies; Female; Humans; Immunosuppressive Agents; Incidence; Male; Methotrexate; Middle Aged; Mortality; Myocardial Infarction; North America; Outcome Assessment, Health Care; Prednisone; Prospective Studies; Regression Analysis; Risk | 2004 |
Rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2004 |
Progression of myelodysplasia during low-dose methotrexate therapy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Myelodysplastic Syndromes | 2004 |
[Case of rheumatoid arthritis presenting with pulmonary tuberculosis].
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha | 2004 |
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Immunoglobulin G; Lymphotoxin-alpha; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Carrier Proteins; Cross-Sectional Studies; Erythrocytes; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polyglutamic Acid; Polymorphism, Genetic; Reduced Folate Carrier Protein; Thymidylate Synthase; Treatment Outcome | 2004 |
Atlanto-odontoid osteoarthritis in rheumatoid arthritis: dynamic CT findings.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Atlanto-Axial Joint; Female; Humans; Male; Methotrexate; Middle Aged; Neck Pain; Osteoarthritis; Tomography, X-Ray | 2004 |
Chlamydial infection preceding the development of rheumatoid arthritis: a brief report.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Drug Therapy, Combination; Female; Humans; Lactones; Methotrexate; Sulfasalazine; Sulfones; Synovial Fluid; Treatment Outcome | 2004 |
Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Interleukin-1; Interleukin-6; Joints; Male; Methotrexate; Mice; Mice, Inbred DBA; p38 Mitogen-Activated Protein Kinases; Prednisolone; Terpenes; Tumor Necrosis Factor-alpha | 2004 |
Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis.
Topics: Algorithms; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Bone Density; CD11a Antigen; Collagen; Male; Methotrexate; Mice; Mice, Inbred DBA; Osteogenesis; Tomography, X-Ray Computed | 2004 |
A linguistic framework for assessing the quality of written patient information: its use in assessing methotrexate information for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Linguistics; Methotrexate; Pamphlets; Patient Education as Topic; Quality Assurance, Health Care; Writing | 2005 |
Noncardiogenic pulmonary edema in low-dose oral methotrexate therapy.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung; Methotrexate; Pulmonary Edema; Tomography, X-Ray Computed | 2004 |
Adalimumab: new preparation. Rheumatoid arthritis: no therapeutic advance.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Drug Therapy, Combination; France; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Methotrexate toxicity induced by acute renal failure.
Topics: Acute Kidney Injury; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged | 2004 |
Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantigens; Autoimmune Diseases; Autoimmunity; beta 2-Glycoprotein I; DNA; Follow-Up Studies; Glycoproteins; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Infliximab; Methotrexate; Prospective Studies; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2004 |
Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas.
Topics: Arthritis, Rheumatoid; Cell Line, Tumor; DNA, Viral; Epstein-Barr Virus Infections; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma; MAP Kinase Kinase Kinases; Methotrexate; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; Polymyositis; Promoter Regions, Genetic; Signal Transduction; Viral Load | 2004 |
Cost effectiveness of adalimumab in the treatment of patients with moderate to severe rheumatoid arthritis in Sweden.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Models, Economic; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor; ROC Curve; Sweden; Treatment Outcome | 2005 |
Rheumatoid arthritis treatment progressing.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Atorvastatin; Cyclophosphamide; Drug Therapy, Combination; Heptanoic Acids; Humans; Methotrexate; Pyrroles; Rituximab | 2004 |
Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Base Sequence; Chromatography, High Pressure Liquid; DNA Primers; gamma-Glutamyl Hydrolase; Humans; Membrane Transport Proteins; Methotrexate; Middle Aged; Polyglutamic Acid; Polymorphism, Genetic; Reduced Folate Carrier Protein | 2004 |
Measuring the efficacy and effectiveness of rheumatoid arthritis therapy: time to change our thinking and adopt a new model.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Forecasting; Humans; Immunosuppressive Agents; Methotrexate; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: interaction with platelets.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Biomarkers; Blood Platelets; Case-Control Studies; Female; Flow Cytometry; Humans; Infliximab; Integrins; Male; Methotrexate; Middle Aged; Monocytes; Neutrophils; P-Selectin; Probability; Prognosis; Receptors, IgG; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric | 2004 |
Low dose methotrexate in the first trimester of pregnancy: results of a French collaborative study.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Prospective Studies; Registries; Risk Assessment | 2004 |
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.
Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12 | 2004 |
[Pneumocystis pneumonia -- atypical manifestation in an immunosuppressed patient with rheumatoid arthritis].
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Pneumonia, Pneumocystis; Prednisolone; Radiography, Thoracic; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination | 2004 |
Adalimumab: human recombinant immunoglobulin g1 anti-tumor necrosis factor monoclonal antibody.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Crohn Disease; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2004 |
Long-term relief for RA? Potential therapy targets cells that, in rheumatoid arthritis, short circuit and attack the body.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Combined Modality Therapy; Cyclosporine; Humans; Methotrexate; Rituximab | 2004 |
[Haemopericardium in rheumatoid arthritis treated with methotrexate].
Topics: Acute Disease; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Methotrexate; Pericardial Effusion | 2004 |
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Drug Interactions; Epstein-Barr Virus Infections; Female; Humans; Lactones; Lymphoproliferative Disorders; Methotrexate; Sulfones | 2002 |
New drugs for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2004 |
Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 2005 |
New drugs for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Methotrexate; Regression Analysis; Tumor Necrosis Factor-alpha | 2004 |
The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse drug reactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cause of Death; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis | 2005 |
Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Phenotype; Time Factors | 2005 |
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex | 2006 |
Folic acid supplementation during methotrexate treatment: nonsense?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Folic Acid; Gastritis, Atrophic; Humans; Methotrexate | 2005 |
Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cross-Sectional Studies; Erythrocytes; Female; Humans; Hydroxymethyl and Formyl Transferases; Linear Models; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polyglutamic Acid; Pteroylpolyglutamic Acids; Reduced Folate Carrier Protein; Severity of Illness Index; Thymidylate Synthase | 2005 |
Drug efflux transporters in rheumatoid arthritis: comment on the article by Kremer.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Humans; Methotrexate | 2005 |
Wild chamomile (Matricaria recutita L.) mouthwashes in methotrexate-induced oral mucositis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Flowers; Humans; Immunosuppressive Agents; Matricaria; Methotrexate; Mouthwashes; Phytotherapy; Plant Extracts; Stomatitis | 2005 |
Methotrexate and oral ulceration.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Oral Ulcer | 2005 |
Treatment continuation in patients receiving biological agents or conventional DMARD therapy.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Immunologic Factors; Infliximab; Interleukin 1 Receptor Antagonist Protein; Male; Methotrexate; Middle Aged; Patient Dropouts; Receptors, Tumor Necrosis Factor; Registries; Sialoglycoproteins; Treatment Failure; Tumor Necrosis Factor-alpha | 2005 |
Oral methotrexate in ulcerative colitis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Colitis, Ulcerative; Female; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome | 2005 |
[Examination of the escape phenomenon in disease modifying antirheumatic drugs].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cysteine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Phenylacetates; Recurrence; Secondary Prevention; Sulfasalazine | 2005 |
A de novo, apparently balanced reciprocal translocation in a child with developmental delay whose mother was being treated with low-dose methotrexate at the time of conception.
Topics: Adult; Arthritis, Rheumatoid; Developmental Disabilities; Female; Fertilization; Humans; Infant; Maternal Exposure; Methotrexate; Pregnancy; Translocation, Genetic | 2005 |
Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment.
Topics: Administration, Oral; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Down-Regulation; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes; Receptors, IgG | 2005 |
Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiolitis; Drug Therapy, Combination; Dyspnea; Etanercept; Female; Forced Expiratory Volume; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Treatment Outcome; Vital Capacity | 2005 |
Multicentric reticulohistiocytosis associated with rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biopsy, Needle; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; Histiocytosis, Non-Langerhans-Cell; Humans; Immunohistochemistry; Methotrexate; Pain Measurement; Prednisone; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2005 |
[Treatment with leflunomide in rheumatoid arthritis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Europe; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome | 2005 |
Clinical and radiological disease-course in a Swedish DMARD-treated early RA-inception cohort: an observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gold Sodium Thiomalate; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Prognosis; Radiography; Registries; Sensitivity and Specificity; Severity of Illness Index; Sulfasalazine; Sweden; Treatment Outcome | 2004 |
What to do with TNF failures.
Topics: Abatacept; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Etanercept; Humans; Immunoconjugates; Immunoglobulin G; Lymphocyte Activation; Methotrexate; Receptors, Tumor Necrosis Factor; Treatment Failure; Tumor Necrosis Factor-alpha | 2005 |
Methotrexate in pregnancy.
Topics: Abnormalities, Drug-Induced; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infant, Newborn; Methotrexate; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects | 2005 |
Physical function and health related quality of life: analysis of 2-year data from randomized, controlled studies of leflunomide, sulfasalazine, or methotrexate in patients with active rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Disability Evaluation; Double-Blind Method; Female; Health Status; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Sulfasalazine; Surveys and Questionnaires | 2005 |
Reversing myocardial microvascular disease in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Coronary Angiography; Coronary Circulation; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Male; Methotrexate; Methylprednisolone; Microcirculation; Middle Aged; Prednisolone; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon | 2005 |
Pulmonary coinfection by Pneumocystis carinii and Aspegillus fumigatus in a seronegative arthritis patient treated with low-dose methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspergillosis; Aspergillus fumigatus; Female; Humans; Lung Diseases, Fungal; Methotrexate; Pneumonia, Pneumocystis | 2004 |
Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Drug Antagonism; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Purines | 2005 |
Continuous indices of core data set measures in rheumatoid arthritis clinical trials: lower responses to placebo than seen with categorical responses with the American College of Rheumatology 20% criteria.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Health Status; Humans; Isoxazoles; Leflunomide; Methotrexate; Pain Measurement; Placebos; Randomized Controlled Trials as Topic; Rheumatology; Severity of Illness Index; Societies, Medical; Treatment Outcome; United States | 2005 |
Light chain multiple myeloma in a patient with long-standing rheumatoid arthritis.
Topics: Aged; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Compounds; Humans; Hydroxychloroquine; Immunoglobulin Light Chains; Methotrexate; Multiple Myeloma; Pancytopenia; Penicillamine | 2005 |
West Nile virus meningitis in a chronic immunosuppressed patient with rheumatoid arthritis.
Topics: Aged; Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Male; Meningitis, Viral; Methotrexate; West Nile Fever; West Nile virus | 2005 |
Infliximab therapy in established rheumatoid arthritis: an observational study.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Infections; Infliximab; Male; Methotrexate; Middle Aged; Patient Compliance; Proportional Hazards Models | 2005 |
[So that the patients.would be able to move for a long time after first diagnosis of rheumatism. Approach as an emergency!].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Osteoporosis; Receptors, Tumor Necrosis Factor; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
[When to begin rheumatism treatment? Initial combination therapy helps fastest].
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Prednisolone; Randomized Controlled Trials as Topic; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
[Three joints swollen, blood sedimentation increased. Methotrexate to be given immediately?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Methotrexate related adverse effects in patients with RA.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2) | 2005 |
Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Prognosis; Retrospective Studies; Risk Factors | 2005 |
Urinary excretion of alpha-GST and albumin in rheumatoid arthritis patients treated with methotrexate or other DMARDs alone or in combination with NSAIDs.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Creatinine; Drug Therapy, Combination; Female; Follow-Up Studies; Glutathione Transferase; Humans; Male; Methotrexate; Middle Aged; Time Factors; Treatment Outcome | 2005 |
Frequency, predictors, and economic impact of upward dose adjustment of infliximab in managed care patients with rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Utilization Review; Female; Follow-Up Studies; Humans; Infliximab; Infusions, Parenteral; Male; Managed Care Programs; Methotrexate; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Survival Analysis; Time Factors | 2005 |
Reversible optic neuropathy associated with low-dose methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Color Vision Defects; Evoked Potentials, Visual; Female; Folic Acid; Humans; Methotrexate; Optic Nerve Diseases; Scotoma; Visual Fields | 2005 |
Intra-articular methotrexate in the treatment of rheumatoid arthritis and psoriatic arthritis: a clinical and sonographic study.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Injections, Intra-Arterial; Knee Joint; Male; Methotrexate; Middle Aged; Pain Measurement; Synovial Membrane; Ultrasonography | 2006 |
The cost effectiveness of infliximab for severe treatment-resistant rheumatoid arthritis in the UK.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Drug Resistance; Humans; Infliximab; Markov Chains; Methotrexate; Quality-Adjusted Life Years; United Kingdom | 2005 |
The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cells; Cells, Cultured; Cysteine; Dexamethasone; Elbow; Female; Fibroblasts; Humans; Knee; Methotrexate; Middle Aged; Organogold Compounds; Orthopedic Procedures; Penicillamine; Phenylacetates; Sulfasalazine; Synovial Membrane; Thymidine Phosphorylase | 2005 |
Bioavailability of higher dose MTX comparing oral and subcutaneous administration in patients with RA.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate | 2005 |
[Effectiveness of methotrexate for the escape by salazosulfapyridine].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome | 2005 |
Methotrexate effect on anti-cyclic citrullinated peptide antibody levels in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Humans; Methotrexate; Middle Aged; Peptides, Cyclic | 2005 |
The changing use of disease-modifying anti-rheumatic drugs in individuals with rheumatoid arthritis from the United Kingdom General Practice Research Database.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Utilization; Family Practice; Female; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine; Survival Analysis; United Kingdom | 2005 |
Pulmonary involvement in lifelong non-smoking patients with rheumatoid arthritis and ankylosing spondylitis without respiratory symptoms.
Topics: Adult; Aged; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Pain Measurement; Pulmonary Fibrosis; Respiratory Function Tests; Smoking; Spondylitis, Ankylosing; Sulfasalazine; Tomography, X-Ray Computed | 2006 |
Increase in methotrexate dose in patients with rheumatoid arthritis who have an inadequate response to infliximab.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Treatment Failure; Tumor Necrosis Factor-alpha | 2005 |
Potential failure of contraceptive efficacy in a patient taking methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Contraceptives, Oral, Combined; Drug Interactions; Female; Humans; Menstruation; Methotrexate | 2005 |
Abatacept: a costimulatory inhibitor for treatment of rheumatoid arthritis.
Topics: Abatacept; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Drug Therapy, Combination; Humans; Immunoconjugates; Immunologic Factors; Infusions, Intravenous; Lymphocyte Activation; Methotrexate; Randomized Controlled Trials as Topic; T-Lymphocytes | 2005 |
Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines.
Topics: Acetylcysteine; Annexin A5; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Arthritis, Rheumatoid; Biological Assay; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Immunosuppressive Agents; Jurkat Cells; Leukocytes; Methotrexate; Monocytes; Oxidative Stress; Propidium; Reactive Oxygen Species; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Time Factors; U937 Cells | 2005 |
Safety and efficacy of leflunomide and infliximab versus methotrexate and infliximab combination therapy in rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged | 2005 |
Anaplastic large cell lymphoma in a patient with rheumatoid arthritis taking low dose methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Lymphoma, Large-Cell, Anaplastic; Methotrexate; Middle Aged; Remission Induction; Time Factors; Treatment Outcome | 2006 |
Lethal acute respiratory distress syndrome during anti-TNF-alpha therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Community-Acquired Infections; Drug Therapy, Combination; Etanercept; Fatal Outcome; Female; Glucocorticoids; Humans; Immunocompromised Host; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Middle Aged; Pneumonia, Pneumococcal; Prednisolone; Receptors, Tumor Necrosis Factor; Respiratory Distress Syndrome; Tumor Necrosis Factor-alpha | 2006 |
Classic disease modifying anti-rheumatic drugs (DMARDs) in combination with infliximab. The Finnish experience.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Finland; Follow-Up Studies; Health Surveys; Humans; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Registries; Retrospective Studies; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2006 |
Preventing deaths from methotrexate overdose.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Humans; Medication Errors; Methotrexate | 2005 |
Deaths following methotrexate overdoses by medical staff.
Topics: Accidents; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Female; Humans; Male; Medical Staff, Hospital; Medication Errors; Methotrexate; Middle Aged | 2005 |
DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Autoimmune Diseases; Cohort Studies; Drug Therapy, Combination; Humans; Infliximab; Judgment; Methotrexate; Physicians; ROC Curve; Severity of Illness Index; Surveys and Questionnaires | 2005 |
Magnetic resonance imaging in the differential diagnosis between polymyalgia rheumatica and elderly onset rheumatoid arthritis.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Diagnostic Errors; Glucocorticoids; Hand; Hand Joints; Humans; Ibuprofen; Magnetic Resonance Imaging; Male; Methotrexate; Methylprednisolone; Polymyalgia Rheumatica; Prednisolone; Radiography; Treatment Outcome | 2006 |
IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; Carrier Proteins; Cell Differentiation; Cell-Free System; Cells, Cultured; Female; Flow Cytometry; Humans; Interferon-gamma; Macrophage Colony-Stimulating Factor; Membrane Glycoproteins; Methotrexate; Middle Aged; Monocytes; Osteoarthritis; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocyte Subsets | 2005 |
Images in clinical medicine. Bone changes in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Female; Humans; Metatarsal Bones; Metatarsophalangeal Joint; Methotrexate; Radiography | 2005 |
[Peripheral mononuclear cells and cytokine circulating levels during adalimumab therapy in patients with rheumatoid arthritis].
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Humans; Interleukin-10; Interleukin-6; Leukocytes, Mononuclear; Lymphocytes; Methotrexate; Methylprednisolone; Tumor Necrosis Factor-alpha | 2005 |
The 2005 International Symposium on Advances in Targeted Therapies: what have we learned in the 2000s and where are we going?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Rheumatic Diseases; Rheumatology; Tumor Necrosis Factor-alpha | 2005 |
Is low-dose methotrexate nephrotoxic? Case report and review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Follow-Up Studies; Humans; Kidney Glomerulus; Methotrexate; Middle Aged; Renal Insufficiency | 2005 |
Staphylococcus aureus in patients with rheumatoid arthritis under conventional and anti-tumor necrosis factor-alpha treatment.
Topics: Adalimumab; Adult; Aged; Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Microbiological Techniques; Middle Aged; Mouth; Nose; Oxacillin; Prevalence; Receptors, Tumor Necrosis Factor; Risk Factors; Staphylococcal Infections; Staphylococcus aureus; Tumor Necrosis Factor-alpha | 2005 |
Skin cancer, rheumatoid arthritis, and tumor necrosis factor inhibitors.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Osteoarthritis; Prednisone; Proportional Hazards Models; Risk Factors; Skin Neoplasms; Tumor Necrosis Factor-alpha | 2005 |
Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients.
Topics: Analysis of Variance; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blotting, Western; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Drug Therapy, Combination; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Intercellular Adhesion Molecule-1; Isoxazoles; Jurkat Cells; Leflunomide; Macrophages; Membrane Proteins; Methotrexate; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; T-Lymphocytes | 2006 |
[Rheumatoid arthritis, methotrexate and non-Hodgkins lymphoma. A report of 3 patients].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged | 2005 |
Influence of methotrexate, TNF blockers and prednisolone on antibody responses to pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibody Formation; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Prednisolone; Receptors, Tumor Necrosis Factor | 2006 |
[Early referral and treatment of patients with acute arthritis. Experiences from two early arthritis clinics].
Topics: Acute Disease; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Early Diagnosis; Female; Humans; Male; Methotrexate; Middle Aged; Referral and Consultation; Synovitis; Time Factors | 2005 |
Methotrexate modulates the kinetics of adenosine in humans in vivo.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Female; Forearm; Hemodynamics; Humans; Male; Methotrexate; Middle Aged; Regional Blood Flow; Severity of Illness Index; Vasodilation; Vasodilator Agents | 2006 |
Trends in disease modifying antirheumatic drug prescription in early rheumatoid arthritis are influenced more by hospital setting than patient or disease characteristics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hospitals; Hospitals, District; Hospitals, University; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Odds Ratio; Outpatient Clinics, Hospital; Practice Patterns, Physicians'; Rheumatology | 2006 |
Disease-modifying anti-rheumatic drugs are only one of a number of potential causes of myelosuppression: a careful drug history is necessary to elucidate the cause of an adverse event.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Female; Humans; Lansoprazole; Methotrexate; Omeprazole; Pancytopenia | 2006 |
Methotrexate induced neutropenia associated with coprescription of penicillins: serious and under-reported?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate; Middle Aged; Pancytopenia; Penicillins | 2006 |
Methotrexate induced pancytopenia is rare and concern for it should not limit its use.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Middle Aged; Pancytopenia | 2006 |
Atypical lymphoplasmacytic and immunoblastic proliferation from rheumatoid arthritis: a case report.
Topics: Aged; Arthritis, Rheumatoid; Biomarkers, Tumor; Female; Humans; Immunosuppressive Agents; Lymphatic Diseases; Methotrexate | 2006 |
Iatrogenically-related, fatal methotrexate intoxication: a series of four cases.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Overdose; Female; Forensic Medicine; Humans; Male; Malpractice; Methotrexate; Shock, Septic | 2006 |
Shortening infusion times for infliximab administration.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infliximab; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Treatment Outcome | 2006 |
Development of calciphylaxis after long-term steroid and methotroxate use in a patient with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Calciphylaxis; Drug Therapy, Combination; Fatal Outcome; Female; Follow-Up Studies; Glucocorticoids; Humans; Methotrexate; Radiography; Time Factors | 2005 |
Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.
Topics: Acute Disease; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Lung Diseases; Male; Methotrexate; Tomography, X-Ray Computed; Treatment Outcome | 2005 |
Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Severity of Illness Index | 2005 |
Early rheumatoid arthritis treatments weighed.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Prednisone; Sulfasalazine | 2005 |
[Chronic polyarthritis: erosions are reversible].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Regeneration; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Methotrexate; Osteolysis; Radiography; Treatment Outcome | 2005 |
Do patients with older-onset rheumatoid arthritis receive less aggressive treatment?
Topics: Adult; Age Factors; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Drug Administration Schedule; Drug Therapy, Combination; Drug Utilization; Female; Humans; Immunologic Factors; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Registries; Severity of Illness Index; United States | 2006 |
Oral tuberculosis associated with a treatment with anti-rheumatic drugs.
Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Methotrexate; Mycobacterium tuberculosis; Opportunistic Infections; Tuberculoma; Tuberculosis, Oral; Tumor Necrosis Factor-alpha | 2006 |
Artemether: a new therapeutic strategy in experimental rheumatoid arthritis.
Topics: Animals; Antibodies; Antimalarials; Antirheumatic Agents; Artemether; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Cell Line, Tumor; Cell Survival; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Injections, Intramuscular; Injections, Intraperitoneal; Joints; Male; Matrix Metalloproteinase 2; Methotrexate; Mice; Nitric Oxide; Rats; Rats, Inbred Lew; Time Factors | 2005 |
The effect of infliximab on bone metabolism markers in patients with rheumatoid arthritis.
Topics: Alkaline Phosphatase; Amino Acids; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Remodeling; Bone Resorption; Collagen Type I; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Peptides; Severity of Illness Index | 2006 |
Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Black or African American; Gene Frequency; Haplotypes; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Prospective Studies; Treatment Outcome; White People | 2006 |
[Effective treatment for a methotrexate-associated lymphoproliferative disorder with R-CHOP following administration of rituximab].
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Cyclophosphamide; Doxorubicin; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Male; Methotrexate; Opportunistic Infections; Prednisolone; Rituximab; Vincristine | 2005 |
Reversible Epstein-Barr virus-negative lymphadenopathy and bone marrow involved by Hodgkin's lymphoma in a rheumatoid arthritis patient undergoing long-term treatment with low-dose methotrexate: a case report and review of the literature.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Cells; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Methotrexate; Middle Aged; Neoplasm Regression, Spontaneous; Reed-Sternberg Cells; Time Factors | 2006 |
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Enzymes; Female; Folic Acid; Genetic Markers; Genotype; Glycine Hydroxymethyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Odds Ratio; Thymidylate Synthase | 2006 |
Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Hospitalization; Humans; Immunocompromised Host; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Pneumonia; Prednisone; Risk Factors; Tumor Necrosis Factor-alpha | 2006 |
I've taken methotrexate for several months to control my rheumatoid arthritis, but the bouts of upset stomach have become too much. I read that folic acid can counteract the side effects of methotrexate. Can you tell me more about it?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Stomach Diseases | 2006 |
Splitting high-dose oral methotrexate improves bioavailability: a pharmacokinetic study in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biological Availability; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Models, Biological | 2006 |
Should anti-tumor necrosis factor-alpha be the first therapy for rheumatoid vasculitis?
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Male; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha; Vasculitis | 2006 |
Use of statistical analysis in open extension studies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Etanercept; Immunoglobulin G; Methotrexate; Patient Dropouts; Random Allocation; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Research Design; Rheumatology; Treatment Outcome | 2006 |
[Infections and lymphoma during prolonged immunosuppression in vascular diseases].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Lupus Erythematosus, Systemic; Lymphoma; Methotrexate; Neoplasms; Opportunistic Infections; Receptors, Interleukin-1; Sialoglycoproteins; Tumor Necrosis Factor-alpha; Vasculitis | 2005 |
Kartagener syndrome and rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Female; Humans; Kartagener Syndrome; Methotrexate; Tomography, X-Ray Computed | 2006 |
Epstein-Barr virus infection associated hepatic lymphoma in a patient treated with methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease-Free Survival; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; Liver Neoplasms; Lymphoma, B-Cell; Methotrexate; Middle Aged; Withholding Treatment | 2006 |
Risk factors for vertebral fracture in menopausal or postmenopausal Japanese women with rheumatoid arthritis: a cross-sectional and longitudinal study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Humans; Incidence; Japan; Longitudinal Studies; Lumbar Vertebrae; Menopause; Methotrexate; Middle Aged; Osteoclasts; Osteoporosis; Postmenopause; Risk Factors; Sensitivity and Specificity; Spinal Fractures; Spine; Steroids; Time Factors | 2006 |
Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Down-Regulation; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 2006 |
[Aldalimumab in psoriatic arthritis and as the initial therapy in rheumatoid arthritis].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Psoriatic; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Follow-Up Studies; Germany; Humans; Long-Term Care; Methotrexate; Treatment Outcome; Tumor Necrosis Factor-alpha | 2005 |
[The initial results of the Metex Study].
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Humans; Injections, Subcutaneous; Methotrexate; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Treatment Outcome | 2005 |
Going with the flow: methotrexate, adenosine, and blood flow.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Forearm; Humans; Methotrexate; Regional Blood Flow | 2006 |
Long-term experience with etanercept in the treatment of rheumatoid arthritis in elderly and younger patients: patient-reported outcomes from multiple controlled and open-label extension studies.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Etanercept; Health Status; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Quality of Life; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2006 |
Should aggressive therapy for rheumatoid arthritis require early use of weekly low-dose methotrexate, as the first disease-modifying anti-rheumatic drug in most patients?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2006 |
[Rheumatoid arthritis in adult: beginning the management in 3 months].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; France; Humans; Methotrexate; Prognosis; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Naso-maxillary non-Hodgkin lymphoma associated with methotrexate treatment in a patient with rheumatoid arthritis.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Bleomycin; Cyclophosphamide; Doxorubicin; Female; Humans; Leucovorin; Lymphoma, B-Cell; Maxillary Neoplasms; Methotrexate; Nose Neoplasms; Prednisone; Vincristine | 2006 |
Remission of hepatic metastasis from colon cancer after methotrexate withdrawal.
Topics: Adenocarcinoma, Mucinous; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Colectomy; Colonic Neoplasms; Humans; Liver Neoplasms; Lymphocyte Activation; Male; Methotrexate; T-Lymphocytes, Cytotoxic; Tomography, X-Ray Computed | 2006 |
Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Antigens, Viral; Arthritis, Rheumatoid; Castleman Disease; Cell Nucleus; Female; Herpesvirus 8, Human; HIV Seronegativity; Humans; Immunosuppressive Agents; Interleukin-6; Methotrexate; Nuclear Proteins; Remission Induction; Sarcoma, Kaposi | 2007 |
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase | 2006 |
Cancer drug approved for RA.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Rituximab | 2006 |
Initial combo therapy best way to treat RA. Study shows MTX plus prednisone or the biologic infliximab may stop RA in its tracks.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Prednisone | 2006 |
Disease modifying treatment for feline rheumatoid arthritis.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Breeding; Cat Diseases; Cats; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Isoxazoles; Leflunomide; Male; Methotrexate; Radiography; Treatment Outcome | 2005 |
Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Kidney Diseases; Male; Methotrexate; Protective Agents; Rats; Rats, Wistar | 2006 |
Methotrexate-induced pulmonary non-Hodgkin lymphoma.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Methotrexate; Radionuclide Imaging | 2006 |
Lack of increase in postoperative complications with low-dose methotrexate therapy in patients with rheumatoid arthritis undergoing elective orthopedic surgery.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Elective Surgical Procedures; Female; Humans; Male; Methotrexate; Middle Aged; Orthopedic Procedures; Retrospective Studies; Risk Factors; Surgical Wound Infection | 2006 |
Interstitial pneumonitis associated with infliximab therapy.
Topics: Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunocompromised Host; Immunosuppressive Agents; Infliximab; Lung Diseases, Interstitial; Male; Methotrexate; Prednisolone; Radiography, Thoracic | 2006 |
Methotrexate therapy for rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion.
Topics: Arthritis, Rheumatoid; Evidence-Based Medicine; Follow-Up Studies; Humans; Immunosuppressive Agents; Methotrexate; Practice Guidelines as Topic; Retrospective Studies; Treatment Outcome | 2006 |
Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; C-Reactive Protein; Cysteine; Female; Humans; Joints; Male; Methotrexate; Middle Aged; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2006 |
Low-dose methotrexate-induced pancytopenia.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Prognosis; Risk Factors | 2007 |
Effect of folic acid supplementation on the efficacy of methotrexate treatment in rheumatoid arthritis: comment on the article by Khanna et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Hematinics; Humans; Methotrexate | 2006 |
Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment--a prospective, controlled study.
Topics: Arthritis, Rheumatoid; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet; Female; Humans; Lipids; Male; Methotrexate; Middle Aged; Prednisone; Reference Values; Surveys and Questionnaires; Triglycerides | 2006 |
Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practice.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome | 2006 |
Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Contraindications; Cyclosporine; Disease Progression; Disease Susceptibility; DNA, Neoplasm; Etanercept; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, B-Lymphocyte, Light Chain; Genes, Immunoglobulin; Humans; Immunocompromised Host; Immunoglobulin G; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate; Neoplasm Proteins; Receptors, Tumor Necrosis Factor; Rituximab; Tumor Necrosis Factor-alpha | 2006 |
Cardiovascular risk and rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Female; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Prevalence; Prognosis; Risk Factors; Survival Rate | 2006 |
Medial tibial stress syndrome due to methotrexate osteopathy.
Topics: Aged; Arthritis, Rheumatoid; Bone Diseases; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Syndrome; Tibia | 2006 |
First Latin American position paper on the pharmacological treatment of rheumatoid arthritis.
Topics: Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Caribbean Region; Humans; Latin America; Methotrexate; Rheumatology; Societies, Medical | 2006 |
Remission of a primary thyroid lymphoma after methotrexate withdrawal.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hashimoto Disease; Humans; Lymphoma, B-Cell; Methotrexate; Remission, Spontaneous; Thyroid Neoplasms; Thyroxine | 2006 |
Lupus anticoagulant and ischemic myocardial microangiopathy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Clopidogrel; Echocardiography; Humans; Interleukin 1 Receptor Antagonist Protein; Lupus Coagulation Inhibitor; Male; Methotrexate; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prednisolone; Radionuclide Imaging; Sialoglycoproteins; Ticlopidine | 2006 |
Comparison of the response to infliximab or etanercept monotherapy with the response to cotherapy with methotrexate or another disease-modifying antirheumatic drug in patients with rheumatoid arthritis: results from the British Society for Rheumatology Bi
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2006 |
Infliximab in chronic myelogenous leukemia.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Infliximab; Injections, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Neoplasm, Residual; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome | 2007 |
Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma.
Topics: Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Lymphoma; Methotrexate; Middle Aged | 2006 |
Dermatitis herpetiformis and rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dapsone; Dermatitis Herpetiformis; Epidermis; Humans; Hydroxychloroquine; Male; Methotrexate; Methylprednisolone; Middle Aged | 2006 |
Cost-effectiveness analysis of MTHFR polymorphism screening by polymerase chain reaction in Korean patients with rheumatoid arthritis receiving methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Trees; Female; Genetic Testing; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic | 2006 |
[Acute diarrhea in a patient with rheumatoid arthritis].
Topics: Acute Disease; Albendazole; Animals; Anthelmintics; Arthritis, Rheumatoid; Diarrhea; Gastritis; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisone; Strongyloides stercoralis; Strongyloidiasis | 2006 |
Ulcerative colitis during CTLA-4Ig therapy in a patient with rheumatoid arthritis.
Topics: Abatacept; Antirheumatic Agents; Arthritis, Rheumatoid; Colitis, Ulcerative; Drug Therapy, Combination; Humans; Immunoconjugates; Male; Methotrexate; Middle Aged | 2006 |
Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha | 2006 |
Most rheumatologists are conservative in active rheumatoid arthritis despite methotrexate therapy: results of the PRISME survey.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; France; Health Care Surveys; Humans; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Rheumatology; Surveys and Questionnaires | 2006 |
Summaries for patients. Abatacept for people with active rheumatoid arthritis.
Topics: Abatacept; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Resistance; Female; Humans; Immunoconjugates; Infections; Male; Methotrexate; Middle Aged; Quality of Life; Radiography; Treatment Outcome | 2006 |
Anti-tumor necrosis factor-alpha-induced psoriasis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diclofenac; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Prednisone; Psoriasis; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2006 |
Methotrexate-induced lung injury in patients with rheumatoid arthritis occurs with peripheral blood lymphocyte count decrease.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphocyte Count; Lymphocytes; Male; Methotrexate; Middle Aged | 2006 |
Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Cholesterol, HDL; Drug Therapy, Combination; Female; Humans; Lipid Metabolism; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2006 |
Methtrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases.
Topics: Aged; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Humans; Immunohistochemistry; In Situ Hybridization; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prevalence; RNA, Viral | 2006 |
Giant cell arteritis--the methotrexate debate revisited.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blindness; Drug Therapy, Combination; Female; Giant Cell Arteritis; Humans; Immunosuppressive Agents; Male; Methotrexate; Prednisone | 2006 |
Predictors of infusion reactions during infliximab treatment in patients with arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Infliximab; Infusions, Intravenous; Logistic Models; Male; Methotrexate; Middle Aged; Odds Ratio; Predictive Value of Tests; Risk Factors; Spondylarthropathies | 2006 |
Antirheumatic drug use and the risk of acute myocardial infarction.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Myocardial Infarction; Random Allocation; Treatment Outcome | 2006 |
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Early Diagnosis; Female; Health Status; Humans; Joints; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Severity of Illness Index; Tissue Inhibitor of Metalloproteinases; Treatment Outcome | 2006 |
IL-1B and IL-1RN gene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy.
Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Sialoglycoproteins | 2006 |
Method for the determination of blood methotrexate by high performance liquid chromatography with online post-column electrochemical oxidation and fluorescence detection.
Topics: Arthritis, Rheumatoid; Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Fluorescence; Humans; Methotrexate; Online Systems; Polyglutamic Acid | 2007 |
Autoantibodies, metalloproteinases and bone markers in rheumatoid arthritis patients are unable to predict their responses to infliximab.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Bone Resorption; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infliximab; Isoxazoles; Leflunomide; Male; Metalloproteases; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Rheumatoid Factor; Tumor Necrosis Factor-alpha | 2007 |
Differential effect of methotrexate on the increased CCR2 density on circulating CD4 T lymphocytes and monocytes in active chronic rheumatoid arthritis, with a down regulation only on monocytes in responders.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; CD4-Positive T-Lymphocytes; Chronic Disease; Drug Administration Schedule; Female; Flow Cytometry; Follow-Up Studies; Humans; Immunophenotyping; Lipopolysaccharide Receptors; Male; Methotrexate; Middle Aged; Monocytes; Receptors, CCR2; Receptors, Chemokine; Receptors, CXCR3; Statistics, Nonparametric | 2007 |
HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Case-Control Studies; Female; Gene Frequency; Genetic Linkage; Genotype; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Interleukin-10; Leukocytes; Lipopolysaccharide Receptors; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Retrospective Studies; Statistics as Topic; Treatment Outcome | 2006 |
Infectious myositis involving the piriformis in a patient with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibodies, Monoclonal; Antifungal Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Candidiasis; Drug Therapy, Combination; Female; Fluconazole; Humans; Infliximab; Methotrexate; Middle Aged; Muscle, Skeletal; Myositis; Organophosphates; Staphylococcal Infections; Tomography, X-Ray Computed | 2006 |
EBV-associated synovial lymphoma in a chronically inflamed joint in rheumatoid arthritis receiving prolonged methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Knee Joint; Lymphoma, B-Cell; Male; Methotrexate | 2006 |
Challenges of predicting treatment response in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Glucocorticoids; Humans; Methotrexate; Prognosis; Severity of Illness Index | 2005 |
Adalimumab-associated pulmonary fibrosis.
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Lung; Methotrexate; Pulmonary Fibrosis; Tomography, X-Ray Computed | 2006 |
Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Prescriptions; Humans; Medication Errors; Methotrexate; Pancytopenia; Penicillins; Trimethoprim | 2007 |
IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Anticardiolipin; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Immunoglobulin M; Infections; Infliximab; Male; Methotrexate; Middle Aged; Placebos | 2006 |
Trial of etanercept and methotrexate with radiographic and patient outcomes two-year clinical and radiographic results: Comment on the article by van der Heijde et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Radiography; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2006 |
Removal of methotrexate by peritoneal dialysis and hemodialysis in a single patient with end-stage renal disease.
Topics: Arthritis, Rheumatoid; Fatal Outcome; Humans; Kidney Failure, Chronic; Male; Methotrexate; Middle Aged; Renal Dialysis; Time Factors | 2006 |
Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Resistance; Drug Therapy, Combination; Glucocorticoids; Health Status; Humans; Infliximab; Injections, Intravenous; Methotrexate; Prospective Studies; ROC Curve; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Withholding Treatment | 2006 |
Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Female; Follow-Up Studies; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Odds Ratio; Regression Analysis; Risk Factors; Sulfasalazine | 2006 |
Analysis of p53 and Bak gene mutations in lymphoproliferative disorders developing in rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; bcl-2 Homologous Antagonist-Killer Protein; Female; Humans; Immunohistochemistry; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Mutation; Phenotype; Prognosis; Tumor Suppressor Protein p53 | 2007 |
Galactosylation of IgG from rheumatoid arthritis (RA) patients--changes during therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Galactose; Humans; Immunoglobulin G; Infliximab; Lectins; Methotrexate; Middle Aged; Surface Plasmon Resonance | 2006 |
Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis.
Topics: Alleles; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Enzymes; Folic Acid Antagonists; Humans; Longitudinal Studies; Methotrexate; Middle Aged; Multivariate Analysis; Pharmacogenetics; Polymorphism, Genetic; Prospective Studies; Pteroylpolyglutamic Acids; Severity of Illness Index | 2006 |
Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Inflammation; Joints; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Association of methotrexate effects and single-nucleotide polymorphisms in the folate pathway in rheumatoid arthritis: comment on the article by Wessels et al.
Topics: Alleles; Arthritis, Rheumatoid; Folic Acid Antagonists; Gene Expression Regulation; Humans; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Severity of Illness Index; Tetrahydrofolate Dehydrogenase | 2006 |
Rituximab for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Approval; Drug Therapy, Combination; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2006 |
[Gastropleural fistula due to perforated gastric ulcer].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Fistula; Gastric Fistula; Humans; Methotrexate; Peptic Ulcer Perforation; Pleural Diseases; Prednisolone; Stomach Ulcer; Thoracotomy | 2006 |
Investigation of the clinical effect of large volume leukocytapheresis on methotrexate-resistant rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Interleukin-6; Leukapheresis; Male; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Retreatment; Treatment Failure | 2006 |
Durability of treatment with methotrexate in Venezuelan patients with rheumatoid arthritis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Isoxazoles; Kaplan-Meier Estimate; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Venezuela | 2007 |
Influenza vaccination as model for testing immune modulation induced by anti-TNF and methotrexate therapy in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal; Antibodies, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immune Tolerance; Immunocompetence; Immunoglobulin G; Infliximab; Influenza Vaccines; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha; Vaccination | 2007 |
Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunoenzyme Techniques; Immunophenotyping; Immunosuppressive Agents; In Situ Hybridization; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Neoplasm Staging; Organ Transplantation; RNA, Viral; Survival Rate | 2007 |
Cost effectiveness of tumour necrosis factor-alpha inhibitors as first-line agents in rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Disease Progression; Drug Costs; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Methotrexate; Middle Aged; Quality-Adjusted Life Years; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2006 |
Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Needle; Facial Dermatoses; Female; Follow-Up Studies; Humans; Immunohistochemistry; Long-Term Care; Lymphoproliferative Disorders; Methotrexate; Risk Assessment | 2007 |
Polymorphism of HLA-DR and HLA-DQ in rheumatoid arthritis patients and clinical response to methotrexate--a hospital-based study.
Topics: Adult; Alleles; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Female; Gene Frequency; HLA-DQ Antigens; HLA-DR Antigens; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pakistan; Polymorphism, Genetic; Risk Assessment; Risk Factors; Treatment Outcome | 2006 |
Anaphylactic reaction in a patient with rheumatoid arthritis: a rare side effect of methotrexate with etanercept as a provoking factor?
Topics: Anaphylaxis; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor | 2006 |
Neurologic and morphologic features of dural ectasia in ankylosing spondylitis and rheumatoid arthritis: a case report.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Dilatation, Pathologic; Dura Mater; Humans; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisone; Radiography; Spinal Cord; Spondylitis, Ankylosing; Treatment Outcome | 2006 |
Comment on 'Drug-related pulmonary problems in patients with rheumatoid arthritis'.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Pneumonia; Risk Assessment | 2007 |
Methotrexate and hepatic toxicity in rheumatoid arthritis and psoriatic arthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Arthritis, Psoriatic; Arthritis, Rheumatoid; Child; Female; Humans; Immunosuppressive Agents; Liver; Male; Methotrexate; Middle Aged; Prospective Studies | 2006 |
The effect of methotrexate on bone metabolism markers in patients with rheumatoid arthritis.
Topics: Administration, Oral; Alkaline Phosphatase; Amino Acids; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Remodeling; Bone Resorption; Collagen Type I; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Osteogenesis; Peptides; Postmenopause; Treatment Outcome | 2006 |
Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Epithelioid Cells; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Matrix Metalloproteinases; Methotrexate; Middle Aged; Rheumatoid Nodule; Synovial Membrane | 2006 |
Polymyositis associated with infliximab treatment for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Infliximab; Methotrexate; Middle Aged; Polymyositis; Prednisolone; Tumor Necrosis Factor-alpha | 2006 |
Clinical practice format for choosing a second-line disease modifying anti-rheumatic drug in early rheumatoid arthritis after failure of 6 months' first-line DMARD therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Decision Support Techniques; Drug Administration Schedule; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Practice Guidelines as Topic; Radiography; Receptors, Tumor Necrosis Factor; Rheumatoid Factor; Sulfasalazine; Treatment Failure | 2007 |
Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Fatal Outcome; Humans; Immunosuppressive Agents; Lymphomatoid Granulomatosis; Lymphoproliferative Disorders; Male; Methotrexate; Pneumonia; Pulmonary Alveoli | 2007 |
Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2006 |
Interstitial pneumonitis and anti-tumor necrosis factor-alpha therapy.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspergillus; Bronchoalveolar Lavage; Cryptogenic Organizing Pneumonia; Humans; Infliximab; Lung Diseases, Interstitial; Mast Cells; Methotrexate; Tumor Necrosis Factor-alpha | 2007 |
[Revision of the recommendations of the Commission on Pharmacotherapy of the German society for Rheumatology. Therapy with tumour necrosis factor blockers for inflammatory rheumatic illnesses].
Topics: Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2007 |
Rheumatoid arthritis in a military aviator.
Topics: Adult; Aircraft; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Male; Methotrexate; Military Medicine; Military Personnel; Receptors, Tumor Necrosis Factor; United States | 2007 |
Dyspnea and dry cough in a patient with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cough; Diagnosis, Differential; Dyspnea; Female; Humans; Lung; Lung Diseases; Methotrexate; Pleura; Radiography | 2007 |
I am currently taking methotrexate for my rheumatoid arthritis, but I've heard that it doesn't interact well with penicillin. Are there any other drugs I should not take while taking methotrexate?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate; Penicillins | 2006 |
Spontaneous multiple insufficiency fractures after pelvic abscess and sepsis in a rheumatoid arthritis patient treated with high-load corticosteroid therapy: a case report.
Topics: Abdominal Abscess; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Bone and Bones; Female; Fractures, Bone; Humans; Methotrexate; Middle Aged; Sepsis; Sulfasalazine; Treatment Outcome | 2007 |
A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cohort Studies; Decision Support Techniques; Disease Progression; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis | 2007 |
Effect of the 34C>T variant in the AMPD1 gene on the clinical response to methotrexate in patients with rheumatoid arthritis: comment on the article by Wessels et al.
Topics: AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Genetic Variation; Humans; Methotrexate; Muscle, Skeletal; Pharmacogenetics; Polymorphism, Genetic; Treatment Outcome | 2007 |
Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Resorption; Cell Differentiation; Cells, Cultured; Coculture Techniques; Cysteine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Methotrexate; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; RANK Ligand; Sulfasalazine | 2007 |
[Modern strategy of diagnostics and management of patients with rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Female; Humans; Male; Methotrexate; Prednisone; Pregnancy; Prognosis; Rheumatoid Factor | 2006 |
[Serum concentration of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) correlates with markers of the disease activity in early rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Early Diagnosis; Female; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2006 |
Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis.
Topics: Adalimumab; Antibodies; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2007 |
N-of-1 trial of low-dose methotrexate and/or prednisolone in lieu of anti-CCP, MRI, or ultrasound, as first option in suspected rheumatoid arthritis?
Topics: Anti-Inflammatory Agents; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Early Diagnosis; Humans; Joints; Magnetic Resonance Imaging; Methotrexate; Peptides, Cyclic; Prednisolone; Ultrasonography | 2007 |
Step-up combination versus switching of non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: results from a retrospective observational study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Retrospective Studies; Sulfasalazine; Treatment Failure | 2007 |
Changes in lipid profile during infliximab and corticosteroid treatment in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Apolipoproteins; Arthritis, Rheumatoid; C-Reactive Protein; Cholesterol; Cholesterol, HDL; Drug Administration Schedule; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Infliximab; Lipids; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prednisone | 2007 |
Reply to letter by Yazici and Yazici commenting on the two-year report on the trial of etanercept and methotrexate with radiographic and patient outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2007 |
Comment on Pavy et al.'s original article "Methotrexate therapy for rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion".
Topics: Arthritis, Rheumatoid; Evidence-Based Medicine; Humans; Immunosuppressive Agents; Infections; Methotrexate; Perioperative Care; Practice Guidelines as Topic | 2007 |
Disseminated necrotizing leukoencephalopathy following low-dose oral methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brain Damage, Chronic; Brain Edema; Cerebral Arteries; Cognition Disorders; Dexamethasone; Diffusion Magnetic Resonance Imaging; Dose-Response Relationship, Drug; Female; Gliosis; Glucocorticoids; Humans; Methotrexate; Middle Aged; Nerve Fibers, Myelinated; Neurodegenerative Diseases; Telencephalon; Tomography, X-Ray Computed; Treatment Outcome | 2007 |
Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.
Topics: Adenocarcinoma; Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Brain Diseases; Demyelinating Diseases; Female; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Methotrexate; Phenylpropionates; Prednisolone | 2007 |
Association between rheumatoid arthritis and primary biliary cirrhosis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Liver; Liver Cirrhosis, Biliary; Liver Function Tests; Methotrexate; Middle Aged | 2007 |
Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cell Death; Cell Line, Transformed; Fibroblasts; Gene Expression Profiling; Humans; Immunoassay; Interleukin-1beta; Interleukin-8; Methotrexate; Oligonucleotide Array Sequence Analysis; Prednisolone; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Synovial Fluid | 2007 |
Heart risks of RA drugs compared. Biologics confer same risk as old-fashioned methotrexate; cytotoxic drugs increase cardiac risk.
Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate; Myocardial Infarction; Stroke | 2007 |
Clinical manifestations and treatment of rheumatoid pachymeningitis.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Female; Hearing Loss, Sensorineural; Humans; Magnetic Resonance Imaging; Male; Meninges; Meningitis; Methotrexate; Prednisone; Scleritis; Treatment Outcome | 2007 |
Purulent pericarditis in a patient with rheumatoid arthritis treated with etanercept and methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Pericarditis; Receptors, Tumor Necrosis Factor; Staphylococcal Infections; Staphylococcus aureus; Tumor Necrosis Factor-alpha | 2007 |
Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Drug Therapy, Combination; Health Care Surveys; Humans; Methotrexate; Netherlands; Prednisolone; Randomized Controlled Trials as Topic; Rheumatology; Sulfasalazine; Surveys and Questionnaires | 2007 |
Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Cohort Studies; Etanercept; Female; Health Maintenance Organizations; Humans; Immunocompromised Host; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Risk Factors; Tumor Necrosis Factor-alpha; United States | 2007 |
Transcription regulatory polymorphism -43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Female; Folic Acid Antagonists; Humans; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Regulatory Elements, Transcriptional; Treatment Failure | 2007 |
QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Databases, Factual; Drug Administration Schedule; Drug Utilization; Female; Humans; International Cooperation; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sex Distribution | 2007 |
Risk factors associated with the cumulative survival of low-dose methotrexate in 273 Japanese patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Multivariate Analysis; Retrospective Studies; Risk Factors; Survival Analysis; Treatment Outcome | 2007 |
[Pancytopenia related to low-dose methotrexate: study of five cases and review of the literature].
Topics: Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pancytopenia; Retrospective Studies | 2007 |
The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Incidence; Logistic Models; Longitudinal Studies; Lymphoma; Male; Methotrexate; Middle Aged; Odds Ratio; Risk Factors; SEER Program; Treatment Outcome; Tumor Necrosis Factor-alpha; United States | 2007 |
[Cyclosporine combined with another basic drug for the management of rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cyclosporine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2006 |
Long-term infliximab treatment in rheumatoid arthritis: subsequent outcome of initial responders.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Health Status Indicators; Humans; Immunosuppressive Agents; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Not all "quality-adjusted life years" are equal.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Infliximab; Markov Chains; Methotrexate; Models, Statistical; Quality-Adjusted Life Years; Survival Analysis; Time Factors | 2007 |
Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arylamine N-Acetyltransferase; Female; Haplotypes; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Prospective Studies; Retrospective Studies; Sulfasalazine | 2007 |
Interferon gamma assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Infliximab; Interferon-gamma; Male; Methotrexate; Middle Aged; Prednisolone; Reproducibility of Results; Tuberculin Test; Tuberculosis; Tumor Necrosis Factor-alpha | 2007 |
Pericarditis: a rare complication of methotrexate therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Echocardiography, Doppler; Electrocardiography; Follow-Up Studies; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Pericarditis; Prednisone; Radiography, Thoracic; Tomography, Spiral Computed | 2007 |
Long-term treatment with methotrexate or tumor necrosis factor alpha inhibitors does not increase epstein-barr virus load in patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; DNA, Viral; Etanercept; Female; Health Status; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Tumor Necrosis Factor-alpha; Viral Load | 2007 |
Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis.
Topics: Adalimumab; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Cohort Studies; Dose-Response Relationship, Drug; Etanercept; Female; Glucocorticoids; Humans; Immunoglobulin G; Incidence; Infliximab; Male; Methotrexate; Poverty; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2007 |
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis.
Topics: Aged; AMP Deaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Middle Aged; Models, Genetic; Multienzyme Complexes; Multivariate Analysis; Nucleotide Deaminases; Pharmacogenetics; Polymorphism, Single Nucleotide; Predictive Value of Tests; Pyrophosphatases; Reproducibility of Results; Rheumatoid Factor; Sex Factors; Smoking; Treatment Outcome | 2007 |
Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis after anti-TNF-alpha therapy.
Topics: Adalimumab; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage; Drug Therapy, Combination; Endemic Diseases; Glucocorticoids; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Opportunistic Infections; Philippines; Prednisone; Strongyloides stercoralis; Strongyloidiasis; Tumor Necrosis Factor-alpha | 2007 |
Primary cervical epidural malignant lymphoma with rheumatoid arthritis: a case report.
Topics: Acute Disease; Aged; Antineoplastic Agents; Arthritis, Rheumatoid; Bone Nails; Cervical Vertebrae; Decompression, Surgical; Epidural Neoplasms; Humans; Lymphoma; Methotrexate; Radiography | 2007 |
Methotrexate pneumonia lacking dyspnea and radiographic interstitial patterns during treatment for early rheumatoid arthritis: bronchoalveolar lavage and transbronchial lung biopsy in a differential diagnosis.
Topics: Aged; Arthritis, Rheumatoid; Biopsy, Needle; Bronchoalveolar Lavage Fluid; Cough; Diagnosis, Differential; Humans; Immunosuppressive Agents; Male; Methotrexate; Pneumonia; Pulmonary Alveoli; Radiography, Thoracic | 2007 |
[Progressive epidermal and mucosal skin lesions in a patient with rheumatoid arthritis].
Topics: Administration, Oral; Arthritis, Rheumatoid; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunosuppressive Agents; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Necrosis; Prednisone; Stevens-Johnson Syndrome; Stomatitis, Aphthous | 2007 |
Trends in medication and health-related quality of life in a population-based rheumatoid arthritis register in Malmo, Sweden.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epidemiologic Methods; Female; Glucocorticoids; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Quality of Life; Rheumatology; Severity of Illness Index; Sweden; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis.
Topics: Adult; Aged; Antibody Specificity; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Rheumatoid Factor; Solubility; Synovial Fluid | 2007 |
Overlap of systemic sclerosis and rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Hand; Humans; Immunoglobulin G; Methotrexate; Middle Aged; Radiography; Receptors, Tumor Necrosis Factor; Rheumatology; Scleroderma, Systemic; Treatment Outcome | 2007 |
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Female; Ferredoxin-NADP Reductase; Genotype; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Rheumatic Nodule; Severity of Illness Index; Vitamin B 12 | 2007 |
Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Italy; Logistic Models; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Quality Assurance, Health Care; Receptors, Tumor Necrosis Factor; Remission Induction; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2007 |
Aberrant phenotype of plasmacytoid monocytes in acute myeloid leukemia.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Bone Marrow; Cell Differentiation; Clone Cells; Cytarabine; Fatal Outcome; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid, Acute; Male; Megakaryocytes; Methotrexate; Middle Aged; Monocytes; Neoplasm Proteins; Neoplastic Stem Cells | 2008 |
In rheumatoid arthritis, a polymorphism in the HLA-G gene concurs in the clinical response to methotrexate treatment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genotype; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Methotrexate; Polymorphism, Genetic; Retrospective Studies; Treatment Outcome | 2007 |
[2-year complete remission after withdrawal of methotrexate in a rectal methotrexate-associated diffuse large B-cell lymphoma].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Gene Rearrangement; Genes, Immunoglobulin Heavy Chain; Herpesvirus 4, Human; Humans; Immunocompromised Host; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Male; Methotrexate; Rectal Neoplasms; Remission Induction; Time Factors | 2007 |
Methods to enhance the safety of methotrexate prescribing.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Labeling; Drug Packaging; Drug Therapy, Combination; Folic Acid; Humans; Medication Errors; Methotrexate; Polymyositis; Practice Patterns, Physicians'; Vitamin B Complex | 2007 |
[Pulmonary infections in patients with rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Lung Diseases, Fungal; Male; Methotrexate; Middle Aged; Pneumonia, Bacterial; Prednisolone; Risk Factors; Tumor Necrosis Factor-alpha | 2007 |
Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: relationship with type of latent Epstein-Barr virus infection.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Risk Assessment; Treatment Outcome | 2007 |
Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Cells, Cultured; Drug Resistance; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Infliximab; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2008 |
[Quality of life of Saratov region residents with rheumatoid arthritis].
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Catchment Area, Health; Demography; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Quality of Life; Russia; Surveys and Questionnaires | 2007 |
Improvement of disease activity of rheumatoid arthritis patients from 2000 to 2006 in a large observational cohort study IORRA in Japan.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disabled Persons; Disease Progression; Female; Humans; Japan; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Severity of Illness Index | 2007 |
Methotrexate combined with isoniazid treatment for latent tuberculosis is well tolerated in patients with rheumatoid arthritis: experience from an urban arthritis clinic.
Topics: Adult; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Humans; Immunosuppressive Agents; Isoniazid; Liver Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Secondary Prevention; Tuberculosis; Tumor Necrosis Factor-alpha; Urban Health | 2008 |
[Spontaneous tongue necrosis consecutive to rheumatoid hyperviscosity syndrome. A case report and literature review].
Topics: Aged; Arthritis, Rheumatoid; Blood Viscosity; Cortisone; Diagnosis, Differential; Drug Therapy, Combination; Follow-Up Studies; Humans; Hypergammaglobulinemia; Immunosuppressive Agents; Ischemia; Male; Methotrexate; Necrosis; Regional Blood Flow; Syndrome; Tongue | 2008 |
[Discussion on the necessity of treatment of rheumatoid arthritis with integrative Chinese and Western medicine].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Phytotherapy; Prednisone; Receptors, Tumor Necrosis Factor | 2007 |
[Thinking on the integrative Chinese and Western medicine in treating rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Phytotherapy; Prednisone | 2007 |
Infliximab but not methotrexate induces extra-high levels of VLDL-triglyceride in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infliximab; Lipoproteins, VLDL; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Triglycerides; Tumor Necrosis Factor-alpha | 2007 |
Not steroids again.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Humans; Methotrexate; Peptides, Cyclic; Steroids | 2007 |
[Abbott proposes in Europe and the U.S.A. the approval of Humira (adalimumab) for therapy of juvenile idiopathic arthritis. Pediatric clinical trial shows very promising results in juvenile rheumatoid arthritis].
Topics: Adalimumab; Adolescent; Adult; Age Factors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Crohn Disease; Drug Therapy, Combination; Europe; Humans; Methotrexate; Placebos; Spondylitis, Ankylosing; Time Factors; United States; United States Food and Drug Administration | 2007 |
In active chronic rheumatoid arthritis, dipeptidyl peptidase IV density is increased on monocytes and CD4(+) T lymphocytes.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; CD4-Positive T-Lymphocytes; Dipeptidyl Peptidase 4; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Hemoglobins; Humans; Leukocyte Count; Male; Methotrexate; Middle Aged; Monocytes; Rheumatoid Factor; Statistics, Nonparametric | 2007 |
[Transient leukemoid reaction of plasma cells in a patient with rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Leukemoid Reaction; Methotrexate; Plasma Cells; Sulfasalazine | 2007 |
Intramuscular methotrexate-induced aseptic meningitis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Intramuscular; Male; Meningitis, Aseptic; Methotrexate; Middle Aged | 2007 |
Bone mineral density in older adult patients with rheumatoid arthritis: an analysis of NHANES III.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Cohort Studies; Female; Femur Neck; Humans; Male; Methotrexate; Middle Aged; Nutrition Surveys | 2007 |
Disease activity early in the course of treatment predicts response to therapy after one year in rheumatoid arthritis patients.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Severity of Illness Index; Time Factors; Treatment Outcome | 2007 |
The importance of the disease process and disease-modifying antirheumatic drug treatment in the development of septic arthritis in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Penicillamine; Prednisolone; Risk Assessment; Sulfasalazine | 2007 |
Spontaneous bleeding in a patient of rheumatoid arthritis: a complication after accidental overdose of methotrexate.
Topics: Accidents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Oral Hemorrhage; Risk Factors; Time Factors | 2007 |
Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Female; Folic Acid; Food Supply; Food, Fortified; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 2007 |
Rituximab: new indication. In rheumatoid arthritis: for a few patients, with close monitoring.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Europe; Humans; Methotrexate; Randomized Controlled Trials as Topic | 2007 |
Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Creatinine; Deoxyguanosine; DNA Damage; Humans; Joints; Lysine; Methotrexate; Oxidative Stress; Oxygen; Reactive Oxygen Species; Time Factors; Treatment Outcome | 2007 |
Optimal use of methotrexate: the advantages of tight control.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Methotrexate; Remission Induction | 2007 |
Reversal of multifocal cutaneous lymphoproliferative disease associated with Epstein-Barr virus after withdrawal of methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate; Remission Induction; Skin Diseases | 2007 |
Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Female; Gene Frequency; Genotype; Humans; Male; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged | 2007 |
Aminotransferases are associated with insulin resistance and atherosclerosis in rheumatoid arthritis.
Topics: Abdominal Fat; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cardiovascular Diseases; Carotid Artery Diseases; Cohort Studies; Female; Humans; Insulin Resistance; Logistic Models; Male; Methotrexate; Middle Aged; Models, Biological; Odds Ratio; Risk Assessment; Risk Factors; Ultrasonography; Up-Regulation | 2007 |
Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blood Sedimentation; Body Mass Index; C-Reactive Protein; Female; Humans; Leptin; Male; Methotrexate; Middle Aged; Time Factors | 2008 |
Why publish a secondary analysis of only one treatment group in the Behandelstrategieën voor Reumatoide Artritis trial? Comment on the article by van der Bijl et al.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Humans; Infliximab; Methotrexate; Randomized Controlled Trials as Topic | 2007 |
Clinical inquiries. Are DMARDs effective for rheumatologic diseases besides rheumatoid arthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Azathioprine; Etretinate; Humans; Infliximab; Joint Diseases; Methotrexate; Nail Diseases; Spondylitis, Ankylosing; Sulfasalazine; Tumor Necrosis Factor-alpha | 2007 |
EBV-specific T-cell response and immunosuppression by methotrexate and TNFalpha antagonists in patients with chronic inflammatory joint disease.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Methotrexate; Virus Activation | 2007 |
Decreased ex vivo production of TNF-alpha and IL-8 by peripheral blood cells of patients with rheumatoid arthritis after infliximab therapy.
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cytokines; Female; Humans; Infliximab; Interleukin-8; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2007 |
Population pharmacokinetic investigation of low-dose methotrexate in rheumatoid arthritics Japanese patients.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Models, Biological | 2007 |
Autoimmune diseases. The B cell slayer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Humans; Immunologic Factors; Lymphocyte Depletion; Methotrexate; Multiple Sclerosis; Randomized Controlled Trials as Topic; Rituximab; T-Lymphocytes | 2007 |
Infection of total hip prosthesis by Mycobacterium tuberculosis and Mycobacterium chelonae in a patient with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Hip Prosthesis; Humans; Immunosuppressive Agents; Male; Methotrexate; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Mycobacterium tuberculosis; Opportunistic Infections; Tuberculosis; Tumor Necrosis Factor-alpha | 2008 |
Drug-specific and time-dependent risks of bacterial infection among patients with rheumatoid arthritis who were exposed to tumor necrosis factor alpha antagonists.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Etanercept; Humans; Immunoglobulin G; Incidence; Infliximab; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Risk Factors; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Use of parenteral methotrexate significantly reduces the need for biological therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Middle Aged; Patient Selection; Retrospective Studies; Treatment Outcome | 2008 |
COBRA combination therapy in daily practice--getting back to the future.
Topics: Abatacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunoconjugates; Methotrexate; Prednisolone; Remission Induction; Rheumatology; Rituximab; Sulfasalazine; Treatment Outcome | 2008 |
Rheumatoid arthritis treatment and monitoring of outcomes--where are we [corrected] in 2007?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Health Status; Humans; Methotrexate; Rheumatology; Severity of Illness Index; Treatment Outcome | 2007 |
Early rheumatoid arthritis in a patient with Sjögren's syndrome and pulmonary nodular amyloidosis: clinical implication of early limited use of infliximab.
Topics: Amyloid; Amyloidosis; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Needle; Drug Therapy, Combination; Female; Humans; Infliximab; Lung Diseases; Methotrexate; Middle Aged; Remission Induction; Sjogren's Syndrome; Tomography, X-Ray Computed; Withholding Treatment | 2007 |
Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Gynecomastia; Humans; Male; Methotrexate; Remission Induction; Tacrolimus; Withholding Treatment | 2007 |
Cutaneous mucormycosis complicating methotrexate, prednisone, and infliximab therapy.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Dermatomycoses; Diagnosis, Differential; Drug Therapy, Combination; Entomophthorales; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Mucormycosis; Prednisone; Skin; Tumor Necrosis Factor-alpha | 2007 |
[Anti-TNF alpha therapy: a risk factor for legionella infection].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Legionellosis; Male; Methotrexate; Middle Aged; Opportunistic Infections; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2007 |
Rituximab therapy in rheumatoid arthritis in daily practice.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome | 2008 |
Characteristics and outcome of connective tissue diseases in patients with sickle-cell disease: report of 30 cases.
Topics: Adult; Anemia, Sickle Cell; Antisickling Agents; Arthritis, Rheumatoid; Blood Transfusion; Drug Therapy, Combination; Female; France; Glucocorticoids; Humans; Hydroxyurea; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Male; Methotrexate; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome | 2008 |
The incidence and prevalence of extra-articular and systemic manifestations in a cohort of newly-diagnosed patients with rheumatoid arthritis between 1999 and 2006.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Comorbidity; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Prevalence; Retrospective Studies; Risk Factors; United States | 2008 |
Early treatment reduces the cardiovascular risk factors in newly diagnosed rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisone; Risk Factors | 2008 |
Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs -- comparison of drugs and adverse reactions.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2008 |
Treatment of pregnant and non-pregnant rheumatic patients: a survey among Dutch rheumatologists.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Data Collection; Drug Monitoring; Female; Humans; Male; Methotrexate; Netherlands; Practice Guidelines as Topic; Practice Patterns, Physicians'; Pregnancy; Pregnancy Complications; Rheumatology; Sulfasalazine | 2008 |
Cholesterol crescents and plates in shoulder effusion of a rheumatoid patient.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Fine-Needle; Cholesterol; Disease Progression; Drug Resistance; Etanercept; Exudates and Transudates; Follow-Up Studies; Humans; Immunoglobulin G; Male; Methotrexate; Prednisolone; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Shoulder Joint; Synovial Fluid; Treatment Outcome | 2008 |
Comment on: The pharmacogenetics of methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Polymorphism, Single Nucleotide; Treatment Outcome | 2008 |
The effectiveness of leflunomide as a co-therapy of tumour necrosis factor inhibitors in rheumatoid arthritis: a population-based study.
Topics: Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Confounding Factors, Epidemiologic; Disease Progression; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Longitudinal Studies; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2009 |
Kidney disease in RA patients: prevalence and implication on RA-related drugs management: the MATRIX study.
Topics: Adult; Age Distribution; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Function Tests; Male; Methotrexate; Middle Aged; Prevalence; Prospective Studies; Proteinuria; Risk Assessment; Sex Distribution; Urinalysis | 2008 |
An index of only patient-reported outcome measures, routine assessment of patient index data 3 (RAPID3), in two abatacept clinical trials: similar results to disease activity score (DAS28) and other RAPID indices that include physician-reported measures.
Topics: Abatacept; Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Health Status Indicators; Humans; Immunoconjugates; Inflammation; Male; Medical Records; Methotrexate; Multicenter Studies as Topic; Pain Measurement; Patient Participation; Patient Satisfaction; Physicians; Probability; Randomized Controlled Trials as Topic; Range of Motion, Articular; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2008 |
The comparative one-year performance of anti-tumor necrosis factor alpha drugs in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: results from a longitudinal, observational, multicenter study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Registries; Rheumatic Diseases; Spondylitis, Ankylosing; Survival Analysis; Tumor Necrosis Factor-alpha | 2008 |
Primary cutaneous Cryptococcosis during therapy with methotrexate and adalimumab.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cryptococcosis; Cryptococcus neoformans; Dermatomycoses; Female; Finger Injuries; Fluconazole; Humans; Hydroxychloroquine; Methotrexate; Middle Aged | 2008 |
Are Thymidylate synthase and Methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Resistance; Female; Gene Expression Regulation, Enzymologic; Gene Frequency; Humans; India; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Retrospective Studies; Thymidylate Synthase | 2008 |
Safe adalimumab therapy for rheumatoid arthritis in a patient with pre-existing multiple myeloma.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Etoricoxib; Humans; Lactones; Male; Methotrexate; Middle Aged; Multiple Myeloma; Pyridines; Retrospective Studies; Severity of Illness Index; Sulfones | 2008 |
Asymptomatic carriage of Pneumocystis jiroveci in elderly patients with rheumatoid arthritis in Japan: a possible association between colonization and development of Pneumocystis jiroveci pneumonia during low-dose MTX therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Carrier State; Female; Humans; Immunocompromised Host; Japan; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumocystis carinii; Pneumonia, Pneumocystis; Risk Factors | 2008 |
[Case of malignant lymphoma associated with rheumatoid arthritis].
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Cyclophosphamide; Diagnosis, Differential; Doxorubicin; Etoposide; Female; Humans; Lymph Nodes; Lymphoma, B-Cell; Mediastinum; Methotrexate; Prednisolone; Remission Induction; Rituximab; Tomography, X-Ray Computed; Vincristine | 2008 |
Systemic nocardiosis in a case of rheumatoid arthritis treated with tumor necrosis factor blockers.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Infections; Drug Therapy, Combination; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Nocardia Infections; Tumor Necrosis Factor-alpha | 2008 |
Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Gene Frequency; Genotype; Haplotypes; Health Status; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Predictive Value of Tests; Severity of Illness Index; Sulfasalazine; Tetrahydrofolate Dehydrogenase | 2008 |
Eosinophilic pneumonia (EP) associated with rheumatoid arthritis in which drug-induced eosinophilic pneumonia could be ruled out.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Diagnosis, Differential; Glucocorticoids; Humans; Male; Methotrexate; Prednisolone; Pulmonary Eosinophilia | 2008 |
Characteristics and medical management of patients with rheumatoid arthritis and ankylosing spondylitis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Rheumatoid Factor; Spondylitis, Ankylosing; Sulfasalazine; Tumor Necrosis Factor-alpha | 2008 |
Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Drug Therapy, Combination; Epstein-Barr Virus Infections; Female; Glucocorticoids; Humans; Immunocompromised Host; Infliximab; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Prednisolone | 2008 |
Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black or African American; Female; Genetic Predisposition to Disease; Humans; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Peptide Synthases; Pharmacogenetics; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Thymidylate Synthase; White People | 2008 |
Identity of single-nucleotide polymorphisms used in a clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy: comment on the article by Wessels et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Nucleic Acid; Glycine Hydroxymethyltransferase; Humans; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Pharmacogenetics; Polymorphism, Single Nucleotide | 2008 |
Pharmacogenomics of methotrexate in rheumatoid arthritis: does race make a difference?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Racial Groups; Risk Factors | 2008 |
[A case of rheumatoid arthritis complicated with methotrexate-induced pneumonitis and pneumocystis pneumonia].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pneumonia; Pneumonia, Pneumocystis | 2008 |
Low-dose prednisolone in rheumatoid arthritis: adverse effects of various disease modifying antirheumatic drugs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisolone; Retrospective Studies; Sulfasalazine | 2008 |
The place of methotrexate perioperatively in elective orthopedic surgeries in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty; Elective Surgical Procedures; Humans; Methotrexate; Perioperative Care; Wound Healing | 2008 |
[Methotrexate: advantages of subcutaneous administration].
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Middle Aged; Treatment Outcome | 2008 |
A novel predictor of clinical response to methotrexate in patients with rheumatoid arthritis: a pilot study of in vitro T cell cytokine suppression.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Cohort Studies; Female; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-10; Male; Methotrexate; Middle Aged; Pilot Projects; ROC Curve; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2008 |
A report of Epstein-Barr virus-positive primary cutaneous natural killer-/T-cell lymphoma.
Topics: Administration, Oral; Arthritis, Rheumatoid; Biopsy; Epstein-Barr Virus Infections; Female; Humans; Killer Cells, Natural; Lymphocyte Subsets; Lymphoma, T-Cell, Cutaneous; Methotrexate; Middle Aged; Skin | 2008 |
Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study.
Topics: Adult; Aged; Aged, 80 and over; AIDS-Related Opportunistic Infections; Arthritis, Rheumatoid; beta-Glucans; C-Reactive Protein; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Pneumocystis carinii; Pneumonia; Pneumonia, Pneumocystis; Retrospective Studies; Tomography, X-Ray Computed | 2008 |
Diffuse large B-cell lymphoma in a patient with rheumatoid arthritis treated with infliximab and methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Incompatibility; Female; Humans; Infliximab; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Skin Neoplasms; Thoracic Wall; Treatment Outcome | 2008 |
[Modern therapy of rheumatoid arthritis. Joint destruction can be delayed].
Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunologic Factors; Methotrexate; Recombinant Proteins | 2008 |
Cryptogenic organizing pneumonia (COP), as presentation of rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cryptogenic Organizing Pneumonia; Diagnosis, Differential; Etanercept; Humans; Immunoglobulin G; Male; Methotrexate; Radiography, Thoracic; Receptors, Tumor Necrosis Factor; Tomography, X-Ray Computed; Treatment Outcome | 2008 |
Diagnosis and management of rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate | 2008 |
Comment on: Kidney disease in RA patients: prevalence and implication on RA-related drugs management: the MATRIX study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Methotrexate; Renal Insufficiency | 2008 |
N-of-1 trials of expensive biological therapies: a third way?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Trees; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor; Treatment Outcome | 2008 |
Methotrexate.
Topics: Abnormalities, Drug-Induced; Arthritis; Arthritis, Rheumatoid; Drug Interactions; Humans; Infant, Newborn; Methotrexate; Myositis; Neoplasms; Psoriasis; Rheumatic Diseases | 1984 |
Pneumocystis carinii pneumonia following methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pneumonia, Pneumocystis | 1983 |
Anticancer treatments can fight arthritic disorders.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1983 |
Acute lung disease associated with low-dose pulse methotrexate therapy in patients with rheumatoid arthritis.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Pneumonia; Prednisone; Radiography, Thoracic; Respiratory Hypersensitivity | 1983 |
Methotrexate pneumonitis after low-dose therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Male; Methotrexate; Middle Aged; Pneumonia; Pulmonary Fibrosis; Radiography, Thoracic | 1983 |
[The use of immunosuppressive drugs in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate; Neoplasms; Risk | 1983 |
Methotrexate therapy in rheumatoid arthritis: 15 years experience.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Injections, Intramuscular; Liver; Liver Diseases; Methotrexate; Middle Aged | 1983 |
Low-dose methotrexate kinetics in arthritis.
Topics: Absorption; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Kinetics; Male; Methotrexate; Middle Aged; Psoriasis | 1984 |
Resistant rheumatoid arthritis. What to do when conservative therapy doesn't work.
Topics: Antimalarials; Arthritis, Rheumatoid; Cytotoxins; Drug Resistance; Glucocorticoids; Gold; Humans; Immunosuppressive Agents; Infusions, Parenteral; Methotrexate; Penicillamine | 1984 |
Poor long-term results from low-dose methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Time Factors | 1984 |
Toxicity from methotrexate may be dose related.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate | 1983 |
Methotrexate pharmacokinetics after intraarticular injection in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bone Marrow; Deoxyuridine; Humans; Injections, Intra-Articular; Kinetics; Leucovorin; Methotrexate; Synovial Fluid | 1980 |
[Effect of methotrexate (amethopterin) on leukocyte migration in patients with rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Cell Migration Inhibition; Cells, Cultured; Humans; In Vitro Techniques; Methotrexate; Phytohemagglutinins; Streptokinase; T-Lymphocytes | 1982 |
Weekly intravenous methotrexate in the treatment of rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Time Factors | 1982 |
Methotrexate: a perspective of its use in the treatment of rheumatic diseases.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; Chemical and Drug Induced Liver Injury; Female; Gastrointestinal Diseases; Humans; Liver Function Tests; Male; Methotrexate | 1982 |
Methotrexate in the treatment of rheumatoid arthritis; pilot study.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1980 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate | 1995 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate | 1995 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Methotrexate | 1995 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate | 1995 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Lymphoma; Methotrexate | 1995 |
Cyclosporine and methotrexate for severe rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate | 1995 |
[Overdose of methotrexate with a fatal outcome in a patient with rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Drug Overdose; Fatal Outcome; Female; Humans; Methotrexate; Middle Aged | 1995 |
Survival analysis of disease modifying antirheumatic drugs in Spanish rheumatoid arthritis patients.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Male; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Probability; Sex Factors; Spain; Statistics, Nonparametric; Survival Analysis; Time Factors; Treatment Outcome | 1995 |
Survival and drug discontinuation analyses in a large cohort of methotrexate treated rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Survival Analysis; Treatment Outcome | 1995 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Folic Acid; Humans; Methotrexate; Treatment Outcome | 1996 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Tolerance; Erythrocyte Indices; Folic Acid; Humans; Methotrexate | 1996 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Tolerance; Folic Acid; Humans; Methotrexate; Treatment Outcome | 1996 |
Pancytopenia related eosinophilia in rheumatoid arthritis: a specific methotrexate phenomenon?
Topics: Aged; Arthritis, Rheumatoid; Bone Marrow; Eosinophilia; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia | 1995 |
Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy.
Topics: Arthritis, Rheumatoid; Cardiac Tamponade; Humans; Methotrexate; Pleural Effusion | 1995 |
Safe prescribing of methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Overdose; Drug Prescriptions; Humans; Methotrexate | 1995 |
Non-coeliac sprue possibly related to methotrexate in a rheumatoid arthritis patient.
Topics: Adult; Arthritis, Rheumatoid; Biopsy; Celiac Disease; Duodenum; Humans; Male; Methotrexate | 1995 |
Effects of methotrexate on human osteoblasts in vitro: modulation by 1,25-dihydroxyvitamin D3.
Topics: Alkaline Phosphatase; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Remodeling; Bromodeoxyuridine; Calcitriol; Cell Differentiation; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Femur Head; Humans; Immunohistochemistry; Methotrexate; Osteoblasts; Osteocalcin; Radioimmunoassay | 1995 |
Light and electron microscopic analysis of sequential liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy. Followup over long treatment intervals and correlation with clinical and laboratory variables.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Cohort Studies; Female; Humans; Liver; Male; Methotrexate; Microscopy, Electron; Middle Aged; Regression Analysis; Serum Albumin; Time Factors | 1995 |
An audit of methotrexate and folic acid for rheumatoid arthritis. Experience from a teaching centre.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Medical Audit; Methotrexate; Middle Aged; Patient Satisfaction; Prospective Studies; Severity of Illness Index; Treatment Outcome | 1995 |
End-stage liver disease developing with the use of methotrexate in heterozygous alpha 1-antitrypsin deficiency.
Topics: Aged; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Arthritis, Rheumatoid; Biopsy; Chronic Disease; Heterozygote; Humans; Liver; Liver Cirrhosis; Liver Failure; Male; Methotrexate; Phenotype | 1995 |
Acute parvovirus B19-induced pancytopenia in the setting of methotrexate therapy for rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Bone Marrow; Erythema Infectiosum; Female; Humans; Methotrexate; Middle Aged; Pancytopenia; Parvovirus B19, Human | 1995 |
Nursing and the law. Deadly doses of methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Coroners and Medical Examiners; Female; Humans; Malpractice; Medical Staff, Hospital; Medication Errors; Methotrexate; New South Wales | 1995 |
[Experience with long term low dose methotrexate treatment in rheumatoid arthritis and arthritic psoriasis].
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Sedimentation; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged | 1995 |
Usefulness of the American College of Rheumatology recommendations for liver biopsy in methotrexate-treated rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost Savings; Diabetes Mellitus, Type 1; Drug Monitoring; Evaluation Studies as Topic; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Rheumatology; Risk Factors; United States | 1995 |
Effect of patient population characteristics in assessing the efficacy and toxicity of methotrexate in rheumatoid arthritis: comment on the article by Weinblatt et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1995 |
[Methotrexate treatment of amyloidosis secondary to rheumatoid arthritis].
Topics: Amyloidosis; Arthritis, Rheumatoid; Female; Humans; Kidney Diseases; Kidney Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Time Factors | 1995 |
Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cytokines; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes | 1995 |
The relationship of preexisting lung disease to the development of methotrexate pneumonitis in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lung Diseases; Male; Medical Records; Methotrexate; Middle Aged; Pneumonia; Radiography, Thoracic; Time Factors | 1995 |
Methotrexate related B lymphoproliferative disease in a patient with rheumatoid arthritis. Role of Epstein-Barr virus infection.
Topics: Arthritis, Rheumatoid; B-Lymphocytes; Burkitt Lymphoma; Female; Herpesvirus 4, Human; Humans; Lymph Nodes; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Viral Matrix Proteins | 1995 |
Hematopoietic growth factors in rheumatoid arthritis: a critical approach to their use in view of possible adverse effects.
Topics: Adult; Arthritis, Rheumatoid; Bone Marrow Transplantation; Cyclosporine; Female; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Neutropenia; Prednisolone | 1993 |
Generalized pruritus in the rheumatoid patient--consider all possible causes.
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoma, B-Cell; Methotrexate; Middle Aged; Pruritus; Splenic Neoplasms | 1995 |
Leukoencephalopathy in a patient taking low dose oral methotrexate therapy for rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged | 1995 |
Is rheumatoid arthritis caused by an infection?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bacterial Infections; Double-Blind Method; Drug Combinations; Humans; Methotrexate; Minocycline; Organogold Compounds; Placebos; Randomized Controlled Trials as Topic | 1995 |
Severe, disseminated, life threatening herpes zoster infection in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Critical Illness; Female; Herpes Zoster; Humans; Immunosuppression Therapy; Methotrexate; Skin Diseases, Viral | 1995 |
Methotrexate for chronic diseases in adults.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Folic Acid; Humans; Methotrexate; Vitamin B 12 Deficiency | 1995 |
Methotrexate for chronic diseases in adults.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Drug Monitoring; Humans; Methotrexate; Psoriasis | 1995 |
Use of magnetic resonance imaging and positron emission tomography in the assessment of synovial volume and glucose metabolism in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Deoxyglucose; Dose-Response Relationship, Drug; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucocorticoids; Glucose; Humans; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Prednisone; Synovial Membrane; Tomography, Emission-Computed; Wrist Joint | 1995 |
Epstein-Barr virus-associated Hodgkin's lymphoma in a rheumatoid arthritis patient treated with methotrexate and cyclosporin A.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Herpesviridae Infections; Herpesvirus 4, Human; Hodgkin Disease; Humans; Male; Methotrexate; Middle Aged; Tumor Virus Infections | 1995 |
Improved methotrexate patient information.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Patient Education as Topic | 1995 |
Treatment of amyloidosis secondary to rheumatoid arthritis.
Topics: Aged; Amyloidosis; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate; Middle Aged | 1995 |
Total and free methotrexate pharmacokinetics, with and without piroxicam, in rheumatoid arthritis patients.
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Interactions; Female; Half-Life; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Piroxicam; Protein Binding | 1995 |
Does injectable gold retard radiologic evidence of joint damage in psoriatic arthritis?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Case-Control Studies; Chloroquine; Female; Humans; Male; Methotrexate; Middle Aged; Organogold Compounds; Radiography; Steroids | 1995 |
Association of histologically proven rheumatoid arthritis with pulmonary sarcoidosis.
Topics: Arthritis, Rheumatoid; Biopsy; Bronchi; Female; Humans; Methotrexate; Middle Aged; Prednisolone; Sarcoidosis, Pulmonary; Synovial Membrane | 1995 |
Influence of low doses of methotrexate on superoxide anion production by polymorphonuclear leukocytes from patients with rheumatoid arthritis.
Topics: Adult; Aged; Anions; Arthritis, Rheumatoid; Blood Physiological Phenomena; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Middle Aged; Neutrophils; Superoxides | 1995 |
Listeria monocytogenes infection in a patient treated with methotrexate for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Bacteremia; Humans; Listeriosis; Male; Methotrexate; Time Factors | 1995 |
Extraarticular manifestations during methotrexate therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Rheumatoid Nodule; Vasculitis | 1995 |
Gynecomastia following low dose methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Gynecomastia; Humans; Male; Methotrexate; Xeromammography | 1995 |
New perspectives on treating rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone | 1995 |
Gynecomastia in patients with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Gynecomastia; Humans; Male; Methotrexate; Middle Aged | 1994 |
Methotrexate may affect certain T lymphocyte subsets in rheumatoid arthritis resulting in susceptibility to Pneumocystis carinii infection.
Topics: Adult; Arthritis, Rheumatoid; Disease Susceptibility; Humans; Male; Methotrexate; Pneumocystis Infections; T-Lymphocyte Subsets | 1994 |
Methotrexate for chronic diseases in adults.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Crohn Disease; Drug Monitoring; Humans; Methotrexate | 1995 |
Interstitial pneumonia due to cytomegalovirus following low-dose methotrexate treatment for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Cytomegalovirus; Cytomegalovirus Infections; Dose-Response Relationship, Drug; Female; Humans; Lung Diseases, Interstitial; Methotrexate; Middle Aged | 1995 |
Creating a care-effective cost-effective strategy for methotrexate liver toxicity monitoring in rheumatoid arthritis: comment on the article by Kremer et al.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Delivery of Health Care; Humans; Liver Diseases; Methotrexate | 1995 |
Associations of IgA and IgA-rheumatoid factor with disease features in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Auranofin; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin A; Immunoglobulin M; Male; Methotrexate; Middle Aged; Monocytes; Prednisolone; Rheumatoid Factor | 1994 |
[Low dosage methotrexate treatment in chronic polyarthritis].
Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hemoglobinometry; Humans; Long-Term Care; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Range of Motion, Articular; Rheumatoid Factor | 1994 |
Methotrexate in rheumatoid arthritis--a limited sampling strategy for estimation of the area under the plasma concentration versus time curve.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Child, Preschool; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Regression Analysis; Time Factors | 1994 |
The total costs of drug therapy for rheumatoid arthritis. A model based on costs of drug, monitoring, and toxicity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Boston; Decision Trees; Diagnosis-Related Groups; Drug Costs; Drug Monitoring; Gold; Health Care Costs; Hospitals, University; Humans; Hydroxychloroquine; Massachusetts; Methotrexate; Models, Economic; New Hampshire; Penicillamine; Sensitivity and Specificity | 1995 |
The cost-effectiveness of liver biopsy in rheumatoid arthritis patients treated with methotrexate.
Topics: Arthritis, Rheumatoid; Biopsy; Cost-Benefit Analysis; Decision Support Techniques; Decision Trees; Female; Humans; Life Expectancy; Liver; Liver Cirrhosis; Methotrexate; Middle Aged; Quality of Life; Sensitivity and Specificity; Value of Life | 1995 |
Unsubstantiated "risk" of antifolate toxicity with combination methotrexate and sulfasalazine therapy.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Risk Factors; Sulfasalazine | 1993 |
[Basic therapy of rheumatoid arthritis. Comparison of methotrexate and sulfasalazine].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Range of Motion, Articular; Sulfasalazine | 1993 |
Influence of corticosteroid pulse therapy on the serum levels of soluble interleukin 2 receptor, interleukin 6 and interleukin 8 in patients with rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Female; Gold; HLA-DR Antigens; Humans; Hydrocortisone; Infusions, Intravenous; Interleukin-6; Interleukin-8; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; Receptors, Interleukin-2; Rheumatoid Factor; Sex Hormone-Binding Globulin; Sulfasalazine | 1994 |
[Study on combined of auranofin, salazosulfapyridine and methotrexate in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Auranofin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Sulfasalazine | 1994 |
Interference of circulating azathioprine but not methotrexate or sulfasalazine with measurements of interleukin-6 bioactivity.
Topics: Arthritis, Rheumatoid; Azathioprine; Biological Assay; Humans; Hybridomas; Interleukin-6; Methotrexate; Sulfasalazine | 1994 |
Cirrhosis in patients with rheumatoid arthritis receiving low dose methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Humans; Liver; Liver Cirrhosis; Male; Methotrexate | 1994 |
Renal effect of low dose methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Kidney; Methotrexate; Research Design | 1994 |
Intraindividual variability of the bioavailability of low dose methotrexate after oral administration in rheumatoid arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Biological Availability; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged | 1994 |
Acute diffuse muscular pain following initiation of methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Muscular Diseases; Pain | 1994 |
Methotrexate-related pulmonary complications in patients with rheumatoid arthritis: cluster of five cases in a period of three months.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lung; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged | 1994 |
Microheterogeneity of alpha 1-acid glycoprotein in patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Orosomucoid; Time Factors | 1994 |
Augmented expression of inflammatory cytokines and adhesion molecules in accelerated nodulosis during methotrexate therapy.
Topics: Arthritis, Rheumatoid; Cell Adhesion Molecules; Cytokines; Female; Humans; Methotrexate; Middle Aged; Skin Diseases | 1994 |
A Canadian survey of current methotrexate prescribing practices in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Canada; Cross-Sectional Studies; Data Collection; Drug Administration Schedule; Drug Prescriptions; Humans; Liver Function Tests; Methotrexate; Practice Patterns, Physicians'; Rheumatology; Surveys and Questionnaires | 1994 |
Underrecognized postdosing reactions to methotrexate in patients with rheumatoid arthritis.
Topics: Administration, Oral; Arthralgia; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Fatigue; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Muscular Diseases; Pain; Time Factors | 1994 |
Plasma thiols, copper and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds | 1994 |
Drugs for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Organogold Compounds; Steroids | 1994 |
Combination therapy with methotrexate and sulphasalazine in rheumatoid arthritis--tolerance of therapy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine | 1994 |
Detailed immunohistologic evaluation of a methotrexate-induced nodule.
Topics: Arthritis, Rheumatoid; CD4-CD8 Ratio; HLA-D Antigens; Humans; Immunohistochemistry; Male; Methotrexate; Middle Aged; Necrosis | 1994 |
Cell-type specific response of peripheral blood lymphocytes to methotrexate in the treatment of rheumatoid arthritis.
Topics: Adult; Antibody Specificity; Arthritis, Rheumatoid; Female; Humans; Injections, Intravenous; Killer Cells, Natural; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; T-Lymphocytes | 1994 |
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cytokines; Female; Humans; Male; Methotrexate; Middle Aged; Monocytes; Osmolar Concentration; Receptors, Cytokine; Solubility; Time Factors | 1994 |
[Computer tomography in scanning of lungs in rheumatoid arthritis and methotrexate therapy].
Topics: Arthritis, Rheumatoid; Humans; Lung; Methotrexate; Tomography, X-Ray Computed | 1994 |
Posterior interosseous nerve entrapment in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Nerve Compression Syndromes; Radial Nerve | 1994 |
Suggested guidelines for monitoring liver toxicity in rheumatoid arthritis patients treated with methotrexate: comment on the article by Kremer et al.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Practice Guidelines as Topic | 1994 |
Chloroquine reduces the bioavailability of methotrexate in patients with rheumatoid arthritis. A possible mechanism of reduced hepatotoxicity.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biological Availability; Chloroquine; Humans; Methotrexate; Middle Aged | 1994 |
Localized lymphoma in a patient with rheumatoid arthritis treated with parenteral methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Humans; Incidence; Infusions, Parenteral; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate | 1993 |
Methotrexate exposure prior to and during pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Arthritis, Rheumatoid; Data Collection; Female; Fertilization; Folic Acid Antagonists; Humans; Infant, Newborn; Methotrexate; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Prospective Studies; Time Factors | 1994 |
[Methotrexate therapy of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Liver; Methotrexate | 1994 |
Reconsideration of the effects of methotrexate therapy on radiographic progression in rheumatoid arthritis: comment on the article by Weinblatt et al.
Topics: Arthritis, Rheumatoid; Auranofin; Double-Blind Method; Humans; Methotrexate; Radiography | 1994 |
Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis: frequency of Epstein-Barr virus and other features associated with immunosuppression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dermatomyositis; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; Immunosuppression Therapy; Lymphoma; Male; Methotrexate; Middle Aged; Steroids | 1994 |
Low dose methotrexate therapy--toxic if not taken correctly. Adverse Drug Reactions Advisory Committee.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Australia; Bone Marrow; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Neutropenia; Stomatitis | 1994 |
Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Chemotactic Factors; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gold Sodium Thiomalate; Humans; Interleukin-1; Interleukin-8; Kinetics; Methotrexate; Prostaglandins; Prostaglandins E; Sensitivity and Specificity; Synovial Membrane | 1994 |
Invasive pulmonary aspergillosis associated with low dose methotrexate therapy for rheumatoid arthritis: a case report of treatment with itraconazole.
Topics: Aged; Arthritis, Rheumatoid; Aspergillosis; Humans; Itraconazole; Lung; Lung Diseases, Fungal; Male; Methotrexate; Opportunistic Infections | 1994 |
An Australian survey of current prescribing practices of methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Australia; Health Surveys; Humans; Liver Function Tests; Methotrexate; Surveys and Questionnaires | 1994 |
[Methotrexate pneumonitis. Important to minimize serious adverse effects in treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Methotrexate | 1994 |
[Case reports. Methotrexate therapy may cause pneumonitis].
Topics: Arthritis, Rheumatoid; Female; Humans; Lung; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Radiography | 1994 |
[Neutropenia after the first administration of methotrexate in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Methotrexate; Neutropenia | 1993 |
Even garlic.
Topics: Alanine Transaminase; Arthritis, Rheumatoid; Female; Garlic; Humans; Methotrexate; Middle Aged; Plants, Medicinal | 1994 |
[Severe bone marrow aplasia associated with cloxacillin treatment].
Topics: Aged; Anemia, Aplastic; Arthritis, Rheumatoid; Cloxacillin; Female; Humans; Methotrexate | 1994 |
Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Keratan Sulfate; Male; Methotrexate; Middle Aged; Prednisone; Radiography | 1994 |
Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy.
Topics: Arthritis, Rheumatoid; Cardiac Tamponade; Female; Humans; Methotrexate; Middle Aged; Pleural Effusion; Radiography; Rheumatoid Nodule; Ultrasonography | 1994 |
[State of shock and abdominal pain revealing tamponade caused by rheumatoid arthritis].
Topics: Abdominal Pain; Adrenal Cortex Hormones; Adult; Arthritis, Rheumatoid; Cardiac Tamponade; Drug Therapy, Combination; Echocardiography; Female; Humans; Methotrexate; Pericardial Effusion | 1994 |
Long-term methotrexate in refractory rheumatoid arthritis; concurrent use of prednisone possibly improves drug-survival.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Follow-Up Studies; Humans; Methotrexate; Prednisone; Time Factors | 1994 |
Liver biopsy in patients with RA taking methotrexate.
Topics: Arthritis, Rheumatoid; Biopsy; Humans; Liver; Methotrexate | 1994 |
Methotrexate and sulfasalazine combination therapy: is it worth the risk?
Topics: Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Methotrexate; Sulfasalazine | 1993 |
Porphyria cutanea tarda associated with methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Porphyria Cutanea Tarda | 1993 |
Gold in rheumatoid arthritis: standard, substitute or sham?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Evaluation Studies as Topic; Humans; Meta-Analysis as Topic; Methotrexate; Organogold Compounds | 1993 |
Variability in individual responses of 532 patients with rheumatoid arthritis to first-line and second-line drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Follow-Up Studies; Humans; Hydroxychloroquine; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Prednisone; Probability | 1993 |
Pneumocystis carinii pneumonia associated with low dose methotrexate treatment for rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis | 1994 |
Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.
Topics: Acute Disease; Anemia, Megaloblastic; Arthritis, Rheumatoid; Humans; Leucovorin; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Prednisolone | 1993 |
Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression.
Topics: Adult; Arthritis, Rheumatoid; Collagenases; Female; Gene Expression; Glycoproteins; Humans; Male; Matrix Metalloproteinase 3; Metalloendopeptidases; Methotrexate; Middle Aged; Prospective Studies; RNA, Messenger; Synovial Membrane; Synovitis; Tissue Inhibitor of Metalloproteinases | 1994 |
Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate; Risk Factors | 1994 |
Methotrexate and asthma.
Topics: Arthritis, Rheumatoid; Asthma; Female; Humans; Methotrexate; Middle Aged | 1993 |
Severe bone marrow suppression in a patient with rheumatoid arthritis on methotrexate.
Topics: Arthritis, Rheumatoid; Bone Marrow; Female; Humans; Methotrexate; Middle Aged; Neutropenia; Pancytopenia | 1993 |
Reduced joint counts in controlled clinical trials in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Gold Sodium Thiomalate; Humans; Joints; Methotrexate; Penicillamine; Randomized Controlled Trials as Topic; Severity of Illness Index | 1994 |
The effects of methotrexate on soluble interleukin-2 receptor levels in rheumatoid arthritis: comment on the article by Barrera et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Receptors, Interleukin-2 | 1994 |
Incidence, prevalence and possible risk factors for pneumonitis in patients with rheumatoid arthritis receiving methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Incidence; Male; Methotrexate; Middle Aged; Pneumonia; Prevalence; Risk Factors; Sex Factors | 1994 |
The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Lipoxygenase; Methotrexate; Neutrophils | 1994 |
Leucovorin versus folic acid in the treatment of methotrexate toxicity: comment on the article by Shiroky et al.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 1994 |
Histologic changes in rheumatoid synovitis induced by naproxen and methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Arthritis, Rheumatoid; Female; HLA-DR Antigens; Humans; Male; Methotrexate; Middle Aged; Naproxen; Synovitis | 1993 |
Meta analysis of the effect of methotrexate on radiologic progression in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Meta-Analysis as Topic; Methotrexate; Radiography | 1993 |
Seizure and methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Seizures | 1993 |
Methotrexate mishap.
Topics: Arthritis, Rheumatoid; Female; Humans; Medication Errors; Methotrexate; Middle Aged; Self Administration; Tablets; United Kingdom | 1994 |
Chronic interstitial cystitis occurring during the shift between rheumatoid arthritis and lupus.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Chronic Disease; Cystitis; Female; Humans; Lupus Erythematosus, Systemic; Methotrexate; Middle Aged | 1994 |
[Extra-articular manifestations of rheumatoid arthritis at the time of basic methotrexate treatment: apropos of a case of nodulosis with pericarditis].
Topics: Arthritis, Rheumatoid; Drug Eruptions; Humans; Male; Methotrexate; Middle Aged; Pericardial Effusion; Pericarditis, Constrictive | 1994 |
Infection rate and use of antibiotics in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Rheumatoid; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Prospective Studies; Respiratory Tract Infections; Retrospective Studies; Risk Factors; Skin Diseases, Infectious; Urinary Tract Infections | 1994 |
Methotrexate serum binding in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Blood Proteins; Dialysis; Humans; Methotrexate; Protein Binding; Serum Albumin; Tritium | 1994 |
[Methotrexate. Efficient, but not without hazards in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Risk Factors | 1993 |
[Pancytopenia during low-dosage methotrexate treatment in patients with rheumatoid arthritis].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia | 1993 |
Check that methotrexate dose.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Drug Prescriptions; Hospitalization; Humans; Medication Errors; Methotrexate | 1993 |
Renal effects of aspirin and low dose methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Chromium Radioisotopes; Drug Therapy, Combination; Edetic Acid; Female; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Methotrexate; Middle Aged | 1993 |
Reduction of leukocyte and interleukin-1 beta concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Interleukin-1; Leukocyte Count; Leukocytes; Lymphocyte Subsets; Male; Methotrexate; Middle Aged; Neutrophils; Osmolar Concentration; Synovial Fluid | 1993 |
Pneumonitis complicating low-dose methotrexate therapy for rheumatoid arthritis. Discrepancies between lung biopsy and bronchoalveolar lavage findings.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Bronchoalveolar Lavage Fluid; Bronchoscopy; Diagnosis, Differential; Female; Humans; Lung; Lung Diseases, Interstitial; Methotrexate; Radiography | 1993 |
Treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aurothioglucose; Humans; Injections, Intramuscular; Leukocyte Count; Methotrexate | 1993 |
Comparison of methods for identifying early methotrexate-induced hepatotoxicity in patients with rheumatoid arthritis.
Topics: Adult; Aged; Alanine Transaminase; Aminopyrine; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Breath Tests; Clinical Enzyme Tests; Humans; Imino Acids; Liver; Liver Cirrhosis; Methotrexate; Middle Aged; Organotechnetium Compounds; Predictive Value of Tests; Radionuclide Imaging; Sensitivity and Specificity; Technetium Tc 99m Disofenin | 1993 |
Reversible lymphomas.
Topics: Arthritis, Rheumatoid; Cytomegalovirus; Herpesvirus 4, Human; Humans; Lymphoma; Lymphoproliferative Disorders; Methotrexate | 1993 |
Long-term experience with low dose methotrexate in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Remission Induction; Retrospective Studies; Time Factors; Treatment Outcome | 1993 |
The effect of long-term methotrexate therapy on hepatic fibrosis in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Collagen; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Microscopy, Electron | 1993 |
One year treatment with low dose methotrexate in rheumatoid arthritis: effect on class specific rheumatoid factors.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Severity of Illness Index | 1993 |
Accelerated nodulosis and systemic manifestations during methotrexate therapy for rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prospective Studies; Rheumatic Nodule; Vasculitis | 1993 |
Inverting the therapeutic pyramid: observations and recommendations on new directions in rheumatoid arthritis therapy based on the author's experience.
Topics: Adult; Aged; Arthritis, Rheumatoid; Auranofin; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Severity of Illness Index; Time Factors | 1993 |
Limitations of randomized clinical trials to recognize possible advantages of combination therapies in rheumatic diseases.
Topics: Arthritis, Rheumatoid; Auranofin; Azathioprine; Drug Combinations; Humans; Lupus Erythematosus, Systemic; Methotrexate; Polymyositis; Prednisone; Randomized Controlled Trials as Topic; Selection Bias; Time Factors | 1993 |
Personal experience in the treatment of seropositive rheumatoid arthritis with drugs used in combination.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Prognosis; Severity of Illness Index | 1993 |
Comparing the strengths and weaknesses of observational and experimental studies using a postmarketing surveillance study as a protypic example.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Severity of Illness Index | 1993 |
Postoperative results of rheumatoid arthritis patients on methotrexate at the time of reconstructive surgery of the hand.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Hand; Humans; Male; Methotrexate; Middle Aged; Postoperative Complications; Postoperative Period; Retrospective Studies; Wound Healing | 1993 |
[Rheumatoid arthritis. Therapeutic efficacy of methotrexate and its hepatotoxic effects].
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Prospective Studies | 1993 |
Adverse effects of low dose methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Gastrointestinal Diseases; Humans; Leukopenia; Linear Models; Male; Methotrexate; Middle Aged; Pneumonia; Predictive Value of Tests; Prevalence; Retrospective Studies; Risk Factors; Time Factors | 1993 |
Association of methotrexate treatment with a decrease of double negative (CD4-CD8-) and gamma/delta T cell levels in patients with juvenile rheumatoid arthritis.
Topics: Adolescent; Arthritis, Rheumatoid; Blood Sedimentation; CD4 Antigens; CD4-CD8 Ratio; CD8 Antigens; Cells, Cultured; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Male; Methotrexate; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 1993 |
Fatal cardiac nodules in a patient with rheumatoid arthritis treated with low dose methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Rheumatic Heart Disease; Rheumatoid Nodule | 1993 |
Issues in the study of azathioprine, methotrexate, and combination therapy: comment on the article by Willkens et al.
Topics: Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Humans; Methotrexate | 1993 |
Folic acid supplementation during methotrexate therapy: it makes sense.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 1993 |
Intestinal absorption in patients with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Duodenum; Female; Humans; Intestinal Absorption; Male; Methotrexate; Middle Aged; Xylose | 1993 |
Fatal outcome of low-dose methotrexate therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Middle Aged; Pancytopenia | 1993 |
Aggressive drug therapy for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Gold; Humans; Life Expectancy; Male; Methotrexate; T-Lymphocytes | 1993 |
Pancytopenia associated with low dose methotrexate therapy. A regional survey.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Urea Nitrogen; Canada; Creatinine; Dose-Response Relationship, Drug; Female; Folic Acid; Health Surveys; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pancytopenia; Psoriasis; Risk Factors; Surveys and Questionnaires; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Renal effects of low dose methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chromium Radioisotopes; Dose-Response Relationship, Drug; Edetic Acid; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Technetium Tc 99m Mertiatide | 1993 |
Acute leukemia after low dose methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Acute Disease; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Myeloid; Methotrexate | 1993 |
Brief report: reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dermatomyositis; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Tumor Virus Infections | 1993 |
Nonperipheral accelerated nodulosis in a methotrexate-treated rheumatoid arthritis patient.
Topics: Arthritis, Rheumatoid; Humans; Lung; Lung Diseases; Male; Methotrexate; Middle Aged; Radiography; Rheumatoid Nodule | 1993 |
Liver cirrhosis in rheumatoid arthritis patients treated with long-term methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Diabetes Mellitus, Type 2; Female; Humans; Liver Cirrhosis; Long-Term Care; Male; Methotrexate; Middle Aged; Retrospective Studies | 1993 |
Non-Hodgkin's lymphoma, rheumatoid arthritis and methotrexate.
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged | 1993 |
Dietary intake and circulating vitamin levels of rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Energy Intake; Humans; Methotrexate; Middle Aged; Nutritional Requirements; Nutritional Status; Vitamins | 1993 |
Determinants of serious liver disease among patients receiving low-dose methotrexate for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Incidence; Liver Cirrhosis; Liver Failure; Liver Function Tests; Male; Methotrexate; Middle Aged; Prognosis; Risk Factors | 1993 |
[If I had chronic polyarthritis--current ideas on basic therapy].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrier Proteins; Cytokines; Drug Therapy, Combination; Humans; Immunotherapy; Methotrexate; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 1993 |
Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Dose-Response Relationship, Drug; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate | 1993 |
Methotrexate inhibits proliferation but not interleukin 1 stimulated secretory activities of cultured human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cell Division; Collagenases; Dose-Response Relationship, Drug; Fibroblasts; Growth Inhibitors; Humans; Hyaluronic Acid; Interleukin-1; Methotrexate; Prostaglandins E; Synovial Membrane | 1993 |
Folate supplementation and methotrexate.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Immune Tolerance; Methotrexate | 1993 |
Acute pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pulmonary Fibrosis | 1993 |
Cytotoxic therapy in rheumatoid arthritis.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Methotrexate | 1993 |
Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in community practice.
Topics: Adult; Arthritis, Rheumatoid; Community Medicine; Female; Gastrointestinal Diseases; Glucocorticoids; Hematologic Diseases; Humans; Life Tables; Male; Methotrexate; Middle Aged; Professional Practice; Rheumatology | 1993 |
Possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Hydroxychloroquine; Methotrexate; Rheumatoid Nodule | 1993 |
Can methotrexate reduce the renal toxicity of parenteral gold?
Topics: Arthritis, Rheumatoid; Female; Gold; Humans; Infusions, Parenteral; Kidney; Methotrexate; Middle Aged | 1993 |
What is the best source of useful data on the treatment of rheumatoid arthritis: clinical trials, clinical observations, or clinical protocols?
Topics: Arthritis, Rheumatoid; Clinical Protocols; Humans; Methotrexate; Randomized Controlled Trials as Topic; Severity of Illness Index; Time Factors | 1995 |
Combination drug therapy of seropositive rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cohort Studies; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Remission Induction; Survival Rate; Treatment Outcome | 1995 |
Radical Intervention in Early Rheumatoid Arthritis. The Case for Enteric-Coated Sulphasalazine, Methotrexate and Combination Regimes. Proceedings of a workshop. Camogli, Italy, September 1994.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sulfasalazine | 1995 |
Combination of sulphasalazine and methotrexate in the management of rheumatoid arthritis--view based on personal clinical experience.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine | 1995 |
Prognostic factors for the outcome of methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Interleukin-1; Interleukin-8; Male; Methotrexate; Middle Aged; Prognosis; Treatment Outcome | 1995 |
[The effect of basic therapy on the morphological picture of the rectal mucosa in patients with rheumatoid arthritis].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Intestinal Mucosa; Male; Methotrexate; Middle Aged; Proctoscopy; Rectum; Sulfasalazine | 1995 |
Intravenous cyclophosphamide pulses in the treatment of pyoderma gangrenosum associated with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Female; Humans; Injections, Intravenous; Methotrexate; Pulsatile Flow; Pyoderma Gangrenosum | 1995 |
What explains the variation among rheumatologists in their use of prednisone and second line agents for the treatment of rheumatoid arthritis?
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold; Humans; Hydroxychloroquine; Male; Methotrexate; Practice Patterns, Physicians'; Prednisone; Rheumatology | 1995 |
Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Age Distribution; Antirheumatic Agents; Arthritis, Rheumatoid; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Sex Distribution; Time Factors | 1995 |
In vitro effects of methotrexate on human articular cartilage and bone-derived osteoblasts.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Cell Division; Culture Techniques; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Osteoblasts; Proteoglycans | 1996 |
Methotrexate osteopathy in long-term, low-dose methotrexate treatment for psoriasis and rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Female; Fractures, Stress; Humans; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Osteoporosis; Psoriasis; Radiography | 1996 |
Pulmonary function in patients receiving long-term low-dose methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Lung; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis; Respiratory Function Tests; Rheumatic Diseases; Risk Factors | 1996 |
Occurrence of pulmonary complications during methotrexate therapy in rheumatoid arthritis.
Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchial Diseases; Cohort Studies; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged; Prevalence; Retrospective Studies | 1996 |
Pulmonary function in rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Lung Volume Measurements; Male; Methotrexate; Middle Aged; Prospective Studies; Pulmonary Gas Exchange; Regression Analysis; Risk Factors | 1996 |
Effect of age on the efficacy and tolerance of methotrexate in rheumatoid arthritis.
Topics: Actuarial Analysis; Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chi-Square Distribution; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction | 1996 |
[Appearance of impotence in relation to the use of methotrexate].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Erectile Dysfunction; Humans; Male; Methotrexate; Middle Aged; Time Factors | 1996 |
Methotrexate and liver toxicity: role of surveillance liver biopsy. Conflict between guidelines for rheumatologists and dermatologists.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biopsy; Dermatologic Agents; Humans; Liver; Methotrexate; Practice Guidelines as Topic; Psoriasis | 1996 |
Effects of methotrexate, sulphasalazine and aurothiomalate on polymorphonuclear leucocytes in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Female; Gold Sodium Thiomalate; Humans; Male; Methotrexate; Middle Aged; Neutrophils; Sulfasalazine; Superoxides | 1996 |
Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Exercise; Female; Glucagon; Growth Hormone; Humans; Leucine; Male; Methotrexate; Middle Aged; Proteins; Time Factors; Tumor Necrosis Factor-alpha | 1996 |
Pustular psoriasis induced by hydroxychloroquine: a case report and review of the literature.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Methotrexate; Psoriasis | 1996 |
Epstein-Barr virus and lymphoproliferation in methotrexate-treated rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Blotting, Southern; Female; Herpesvirus 4, Human; Humans; Immunohistochemistry; In Situ Hybridization; Lymphoproliferative Disorders; Methotrexate; Middle Aged | 1996 |
Toxicity of combination therapies in rheumatoid arthritis: comment on the article by Willkens et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Humans; Methotrexate | 1996 |
Total and free methotrexate pharmacokinetics in rheumatoid arthritis patients.
Topics: Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Protein Binding | 1996 |
Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Cell Adhesion; Cell Culture Techniques; Cell Division; Clone Cells; Dose-Response Relationship, Drug; Fibroblasts; Humans; Methotrexate; Synovial Membrane; T-Lymphocytes; Tumor Cells, Cultured | 1996 |
Does exposure to immunosuppressive therapy increase the 10 year malignancy and mortality risks in rheumatoid arthritis? A matched cohort study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Cohort Studies; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Risk Factors; Time Factors | 1996 |
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12 | 1996 |
[Methotrexate; fatal dosage errors due to inattention].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Medication Errors; Methotrexate | 1996 |
[Subcutaneous self-administration of methotrexate in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Self Administration | 1996 |
Mechanisms of the effects of methotrexate.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylation; Rheumatoid Nodule | 1996 |
Nodulosis during methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule | 1995 |
Thrombocytopenia in patients with rheumatoid arthritis on long-term treatment with low dose methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Leukocyte Count; Methotrexate; Middle Aged; Platelet Count; Retrospective Studies; Thrombocytopenia | 1996 |
Soluble interleukin-2-receptor and interleukin-6 changes during low-dose methotrexate treatment in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-2; Interleukin-6; Male; Methotrexate; Middle Aged; Receptors, Interleukin-2; Solubility | 1996 |
Treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Remission Induction; Sulfasalazine | 1996 |
Treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Placebos; Sulfasalazine | 1996 |
Cost evaluation of novel therapeutics in rheumatoid arthritis (CENTRA): a decision analysis model.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Analysis; Decision Support Techniques; Gold; Humans; Immunosuppressive Agents; Methotrexate; Sensitivity and Specificity | 1996 |
[Untoward effects of low dose methotrexate therapy in rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cough; Drug Eruptions; Female; Headache; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Retrospective Studies | 1996 |
Non-Hodgkin's lymphoma in patients with rheumatoid arthritis treated with low dose methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate | 1996 |
Pancytopenia in rheumatoid arthritis patients receiving methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia | 1996 |
Thrombocytopenia in patients with rheumatoid arthritis on long-term treatment with low dose methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Retrospective Studies; Thrombocytopenia; Time Factors | 1996 |
Sustained cough in methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Cough; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Pneumonia; Time Factors | 1996 |
Could the cytomegalovirus be an innocent bystander in methotrexate-treated rheumatoid arthritis patients?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cytomegalovirus Infections; Humans; Methotrexate; Pneumonia, Viral | 1996 |
Validation of the French version of the arthritis impact measurement scales 2 and comparison with the french version of the Nottingham Health Profile. "Quality of Life in Rheumatology" Task Force.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; England; Female; France; Health Status; Health Status Indicators; Humans; Male; Methotrexate; Middle Aged; Psychometrics; Quality of Life; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires | 1996 |
The significance of AST changes in patients with rheumatoid arthritis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Humans; Methotrexate | 1996 |
Historical overview of the treatment of rheumatoid arthritis with an emphasis on methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; History, 19th Century; History, 20th Century; Humans; Methotrexate | 1996 |
Temporal association between the use of methotrexate and development of leukemia in 2 patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Middle Aged; Time Factors | 1995 |
Validity, reliability, and sensitivity to change of a French version of the arthritis impact measurement scales 2 (AIMS2) in patients with rheumatoid arthritis treated with methotrexate.
Topics: Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Demography; Factor Analysis, Statistical; Female; France; Humans; Male; Methotrexate; Middle Aged; Quality of Life; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires | 1996 |
Listeria monocytogenes infection in a patient treated with methotrexate for rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Humans; Listeria monocytogenes; Listeriosis; Male; Methotrexate; Opportunistic Infections; Vasculitis | 1996 |
Longterm effect of methotrexate in Felty's syndrome: a 12 year followup.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Platelets; Felty Syndrome; Follow-Up Studies; Humans; Leukocyte Count; Male; Methotrexate; Neutropenia; Spleen | 1996 |
Rheumatoid arthritis lung disease. Determinants of radiographic and physiologic abnormalities.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Gold; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Multivariate Analysis; Penicillamine; Prevalence; Radiography; Respiratory Function Tests; Smoking | 1996 |
Cytomegalovirus in methotrexate-treated rheumatoid arthritis patients: comment on the concise communication by Aglas et al.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Cytomegalovirus Infections; Female; Humans; Lymphocytes; Methotrexate; Pneumonia, Viral; Transfusion Reaction | 1995 |
Long-term treatment with every-other-week methotrexate in rheumatoid arthritis patients with sustained disease improvement: comment on the article by Kremer et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Methotrexate; Time Factors | 1995 |
Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Middle Aged; Pancytopenia; Survival Analysis | 1996 |
Methotrexate-associated lymphoma in patients with rheumatoid arthritis: report of two cases.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Radiography | 1996 |
A limited sampling method to estimate methotrexate pharmacokinetics in patients with rheumatoid arthritis using a Bayesian approach and the population data modeling program P-PHARM.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Bayes Theorem; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Software | 1996 |
Distinctive features of idiopathic inflammatory myopathies in French Canadians.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Canada; Carcinoma; Carcinoma in Situ; Carcinoma, Squamous Cell; Creatine Kinase; Esophageal Neoplasms; Female; Follow-Up Studies; Histidine-tRNA Ligase; Humans; Longitudinal Studies; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Mixed Connective Tissue Disease; Nuclear Envelope; Polymyositis; Prednisone; Pulmonary Fibrosis; Retrospective Studies; Scleroderma, Systemic; Skin Neoplasms; Survival Analysis | 1996 |
Increase of bone mineral density and anabolic variables in patients with rheumatoid arthritis resistant to methotrexate after cyclosporin A therapy.
Topics: Acute-Phase Proteins; Arthritis, Rheumatoid; Bone Density; C-Reactive Protein; Cyclosporine; Dehydroepiandrosterone Sulfate; Drug Resistance; Female; Humans; Insulin-Like Growth Factor I; Joints; Male; Methotrexate; Middle Aged; Osteocalcin; Retreatment | 1996 |
Results of "satisfaction with disease control" survey.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Health Surveys; Humans; Methotrexate; Patient Satisfaction; Prednisone | 1996 |
The frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Immunohistochemistry; Incidence; Male; Methotrexate; Middle Aged; Peripheral Nervous System Diseases; Skin; Vasculitis | 1996 |
Pancytopenia related eosinophilia in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Eosinophilia; Humans; Methotrexate; Pancytopenia; Penicillamine | 1996 |
An update on the Bath Ankylosing Spondylitis Disease Activity and Functional Indices (BASDAI, BASFI): excellent Cronbach's alpha scores.
Topics: Age of Onset; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate | 1996 |
Clonality of Epstein-Barr virus in lymphoproliferative disorders in patients treated with immunosuppressive therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate | 1996 |
Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma.
Topics: Adenocarcinoma; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Recurrence | 1996 |
Accelerated nodulosis in a patient with psoriasis and arthritis during treatment with methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Methotrexate; Psoriasis; Rheumatic Nodule | 1996 |
[Therapy of rheumatoid arthritis (chronic polyarthritis)].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Methotrexate; Occupational Therapy; Physical Therapy Modalities; Steroids | 1996 |
[Pancytopenia in rheumatoid arthritis treated with methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Retrospective Studies; Risk Factors | 1996 |
Plasma reactive nitrogen intermediate levels in patients with clinically active rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Citrulline; Female; Free Radicals; Humans; Male; Methotrexate; Nitrites; Nitrogen | 1996 |
[Adverse effects of low-dose methotrexate therapy in rheumatoid arthritis].
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cough; Drug Administration Schedule; Drug Eruptions; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nausea; Retrospective Studies | 1996 |
Methotrexate osteopathy, does it exist?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases; Dose-Response Relationship, Drug; Female; Fractures, Stress; Humans; Methotrexate; Middle Aged; Postmenopause; Radiography; Radionuclide Imaging; Time Factors | 1996 |
More on pericardial tamponade during methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiac Tamponade; Female; Humans; Male; Methotrexate; Middle Aged | 1996 |
Methotrexate patient education: a quality improvement study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Educational Measurement; Female; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Nurse Clinicians; Patient Education as Topic; Surveys and Questionnaires; Total Quality Management | 1996 |
Use of methotrexate in older patients. A risk-benefit assessment.
Topics: Aged; Aging; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate; Risk Assessment | 1996 |
Liver cirrhosis due to methotrexate in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Monitoring; Female; Humans; Liver Cirrhosis; Methotrexate; Middle Aged | 1996 |
Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis: comment on the article by Gutierrez-Ureña et al.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Fatal Outcome; Female; Humans; Male; Methotrexate; Middle Aged; Pancytopenia | 1997 |
Incidence of pancytopenia with methotrexate treatment of rheumatoid arthritis in Germany: comment on the article by Gutierrez-Ureña et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Interactions; Female; Germany; Humans; Methotrexate; Pancytopenia; Survival Rate | 1997 |
Agranulocytosis and bone marrow aplasia induced by second-line drugs for rheumatoid arthritis. Treatment with granulocyte colony-stimulating factor.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Compounds; Humans; Male; Methotrexate | 1997 |
Herpes zoster encephalomyelitis associated with low dose methotrexate for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; CD4-CD8 Ratio; Dose-Response Relationship, Drug; Encephalomyelitis; Female; Herpes Zoster; Humans; Immunosuppressive Agents; Methotrexate; Opportunistic Infections | 1997 |
Preoperative evaluation of a woman with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Hematoma, Subdural; Humans; Methotrexate; Middle Aged; Physical Examination; Piroxicam; Postoperative Complications; Prednisone; Preoperative Care | 1997 |
Benefit of simultaneous rhG-CSF and methylprednisolone 'pulse' therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Diseases; Drug Therapy, Combination; Female; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Methylprednisolone; Recombinant Proteins | 1997 |
Variations and trends in the prescription of initial second line therapy for patients with rheumatoid arthritis.
Topics: Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Female; Gold; Humans; Male; Methotrexate; Penicillamine; Practice Patterns, Physicians'; Rheumatology; Sulfasalazine | 1997 |
Malignancy in patients with rheumatoid arthritis treated with methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Multiple Myeloma; Risk Factors | 1997 |
Malignancy in patients with rheumatoid arthritis treated with methotrexate.
Topics: Arthritis, Rheumatoid; Female; Humans; Lymphoma, B-Cell; Methotrexate; Middle Aged; Recurrence | 1997 |
Cutaneous pseudolymphoma occurring during methotrexate therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Humans; Male; Methotrexate; Middle Aged; Pseudolymphoma; Skin Diseases | 1997 |
N-acetyl-beta-D-glucosaminidase urinary excretion as an early indicator of kidney dysfunction in rheumatoid arthritis patients on low-dose methotrexate treatment.
Topics: Acetylglucosaminidase; Adult; Aged; Albuminuria; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Female; Humans; Kidney Diseases; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Uric Acid | 1997 |
Abnormal homocysteine metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Slow progression of joint damage in early rheumatoid arthritis treated with cyclosporin A or methotrexate: comment on the article by Pasero et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Disease Progression; Humans; Joint Diseases; Methotrexate | 1997 |
[Toxicity of low-dose methotrexate in rheumatoid arthritis--clinical characteristics in patients with MTX-induced pancytopenia and interstitial pneumonitis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Female; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Pancytopenia | 1997 |
Quantitative liver function in patients with rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Creatinine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Rheumatoid Factor | 1997 |
Response to therapy in rheumatoid arthritis is influenced by immediately prior therapy.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Disability Evaluation; Drug Administration Schedule; Female; Gold; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Pain Measurement; Penicillamine; Prednisone; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome | 1997 |
Safety, efficacy, and mortality in a long-term cohort of patients with rheumatoid arthritis taking methotrexate: followup after a mean of 13.3 years.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Humans; Methotrexate; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome | 1997 |
Effect of resumption of second line drugs in patients with rheumatoid arthritis that flared up after treatment discontinuation.
Topics: Acute Disease; Aged; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Recurrence; Sulfasalazine; Treatment Outcome | 1997 |
[Rheumatoid arthritis. Begin early aggressive therapy].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate | 1997 |
Long-term follow-up of 453 rheumatoid arthritis patients treated with methotrexate: an open, retrospective, observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Female; Follow-Up Studies; Hand; Histocompatibility Antigens Class II; Humans; Incidence; Joints; Male; Methotrexate; Middle Aged; Platelet Count; Retrospective Studies; Rheumatoid Factor; Time Factors; Vasculitis, Leukocytoclastic, Cutaneous | 1997 |
The importance of high-resolution computed tomography in the diagnosis of interstitial lung disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Methotrexate; Tomography, X-Ray Computed | 1997 |
[Severe adverse effect of methotrexate in rheumatoid arthritis. Don't forget security routines in intercurrent disease!].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Colitis, Ischemic; Female; Humans; Methotrexate | 1997 |
The therapeutic pyramid: a work in progress.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Humans; Methotrexate; Treatment Outcome | 1997 |
Bronchoalveolar lavage cell profile in methotrexate induced pneumonitis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Female; Humans; Immunophenotyping; Lung Diseases, Interstitial; Lymphocyte Subsets; Male; Methotrexate; Middle Aged | 1997 |
The safety of weekly low dose oral methotrexate in an Oriental population with rheumatoid arthritis.
Topics: Administration, Oral; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Safety; Singapore | 1997 |
Is methotrexate oncogenic in patients with rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lymphoma, Non-Hodgkin; Methotrexate | 1997 |
The AIMS2-SF: a short form of the Arthritis Impact Measurement Scales 2. French Quality of Life in Rheumatology Group.
Topics: Activities of Daily Living; Affect; Arthritis, Rheumatoid; Health Status; Humans; Interpersonal Relations; Methotrexate; Psychometrics; Sensitivity and Specificity; Surveys and Questionnaires | 1997 |
Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Humans; Methotrexate; Monocytes; Receptors, Purinergic P1; Rheumatoid Nodule; Tetradecanoylphorbol Acetate; Theobromine; Xanthines | 1997 |
Association of methotrexate, rheumatoid arthritis, and melanoma in 2 patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Melanoma; Methotrexate | 1997 |
Rheumatoid arthritis: not yet curable with early intensive therapy.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone; Sulfasalazine | 1997 |
Antifolate effect of methotrexate: comment on the article by Cronstein.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate | 1997 |
Re: J.M. Kremer--editorial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Practice Guidelines as Topic | 1997 |
Monitoring for methotrexate hepatotoxicity in patients with rheumatoid arthritis: another hepatologist's perspective.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Contraindications; Drug Monitoring; Humans; Liver; Liver Function Tests; Methotrexate; Practice Guidelines as Topic | 1997 |
Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Humans; Life Style; Logistic Models; Lung; Lung Diseases; Male; Methotrexate; Middle Aged; Odds Ratio; Patient Selection; Population Surveillance; Risk; Risk Factors; Socioeconomic Factors | 1997 |
In vitro effect of gold sodium thiomalate and methotrexate on tumor necrosis factor production in normal healthy individuals and patients with rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Gold Sodium Thiomalate; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Methotrexate; Mice; Tumor Necrosis Factor-alpha | 1997 |
Pure red cell aplasia in a man with RA.
Topics: Aged; Arthritis, Rheumatoid; Danazol; Humans; Male; Methotrexate; Red-Cell Aplasia, Pure; Sulfasalazine | 1997 |
Photodynamic therapy for rheumatoid arthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Chi-Square Distribution; Chloroquine; Fibroblasts; Humans; Laser Therapy; Methotrexate; Photochemotherapy; Piroxicam; Sclerosing Solutions; Sodium Morrhuate | 1997 |
Total and free methotrexate pharmacokinetics in elderly patients with rheumatoid arthritis. A comparison with young patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Creatinine; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1997 |
Methotrexate osteopathy.
Topics: Arthritis, Rheumatoid; Fractures, Bone; Humans; Methotrexate; Osteoporosis; Risk Factors | 1997 |
Methotrexate pneumonitis in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pneumonia | 1997 |
Importance of psychological well being and disease activity in termination of an initial DMARD therapy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude to Health; Cohort Studies; Female; Health Status; Humans; Male; Methotrexate; Middle Aged; Probability; Psychological Tests; Risk Factors; Sulfasalazine; Treatment Outcome | 1997 |
Perioperative use of methotrexate--a survey of clinical practice in the UK.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Data Collection; Drug Utilization; Humans; Methotrexate; Perioperative Care; Postoperative Complications; Practice Patterns, Physicians'; United Kingdom | 1997 |
[Effects of low dose methotrexate therapy in rheumatoid arthritis: a comparison of three different dosage regimens].
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retrospective Studies | 1997 |
Pre-treatment X-rays for rheumatoid arthritis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Lung Diseases; Methotrexate; Radiography, Thoracic | 1997 |
Differences in the use of second-line agents and prednisone for treatment of rheumatoid arthritis by rheumatologists and non-rheumatologists.
Topics: Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prednisone; Retrospective Studies; Rheumatology | 1997 |
Clinical characteristics of patients with rheumatoid arthritis and methotrexate induced pneumonitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Cytomegalovirus Infections; Diagnosis, Differential; Female; Humans; Male; Methotrexate; Middle Aged; Pneumonia; Pneumonia, Pneumocystis; Retrospective Studies; Risk Factors | 1997 |
Herpes zoster encephalomyelitis in a patient with rheumatoid arthritis treated with low dose methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Encephalomyelitis; Female; Herpes Zoster; Humans; Methotrexate; Middle Aged | 1997 |
A retrospective study of treating RA patients with various combinations of slow-acting antirheumatic drugs in a county hospital.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Drug Therapy, Combination; Gold; Hospitals, County; Humans; Hydroxychloroquine; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine | 1997 |
Cutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: a possible manifestation of methotrexate hypersensitivity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Methotrexate; Middle Aged; Vasculitis, Leukocytoclastic, Cutaneous | 1997 |
[Disturbed neutrophil activation in pneumonia during medicinal immunosuppression].
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemotaxis; Cyclophosphamide; Humans; Immunosuppression Therapy; Kidney Transplantation; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutrophil Activation; Pneumonia; Postoperative Complications | 1997 |
Methotrexate and trimethoprim: a fatal interaction.
Topics: Aged; Arthritis, Rheumatoid; Drug Interactions; Fatal Outcome; Female; Humans; Methotrexate; Trimethoprim | 1998 |
Methotrexate and cyclooxygenase metabolism in cultured human rheumatoid synoviocytes.
Topics: Antirheumatic Agents; Arachidonic Acid; Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Folic Acid Antagonists; Humans; Isoenzymes; Membrane Proteins; Methotrexate; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Synovial Membrane | 1998 |
[Therapy of refractory rheumatoid arthritis. Cyclosporin and methotrexate combination].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Magnetic Resonance Imaging; Methotrexate; Methylprednisolone; Time Factors | 1998 |
Leukocytoclastic vasculitis induced by low-dose methotrexate: in vitro evidence for an immunologic mechanism.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Degranulation; Drug Hypersensitivity; Female; Fluorescent Antibody Technique, Direct; Humans; Mast Cells; Methotrexate; Skin Diseases, Vascular; Vasculitis, Leukocytoclastic, Cutaneous | 1998 |
[Clinical relapse of rheumatoid arthritis (escape phenomenon) during low-dose methotrexate therapy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1998 |
[The efficacy of combination therapy with prednisolone (PSL) and methotrexate (MTX) on radiographic progression in patients with rheumatoid arthritis (RA)].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Hand; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Radiography; Retrospective Studies | 1998 |
First-time manifestation of generalized Wegener's granulomatosis despite methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Giant Cell Arteritis; Granulomatosis with Polyangiitis; Humans; Male; Methotrexate; Middle Aged | 1998 |
Lymphoma with regression after methotrexate withdrawal in a patient with rheumatoid arthritis. Role for the Epstein-Barr virus.
Topics: Antigens, Viral; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immunocompromised Host; Lymphoma, T-Cell; Methotrexate; Middle Aged; Remission Induction; RNA, Viral; Tumor Virus Infections | 1998 |
[Sandimmun Optoral now approved in Germany. Treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Approval; Drug Combinations; Germany; Humans; Methotrexate | 1998 |
Methotrexate in rheumatoid arthritis: a 2 year experience at a university hospital in Pakistan.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Therapy, Combination; Female; Follow-Up Studies; Gold; Hospitals, University; Humans; Male; Methotrexate; Middle Aged; Penicillamine; Retrospective Studies; Sulfasalazine; Treatment Outcome | 1998 |
Effects of moderate renal insufficiency on pharmacokinetics of methotrexate in rheumatoid arthritis patients.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Female; Humans; Male; Methotrexate; Middle Aged; Renal Insufficiency | 1998 |
Pancytopenia secondary to hemophagocytic syndrome in rheumatoid arthritis treated with methotrexate and sulfasalazine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bacteremia; Bone Marrow Cells; Escherichia coli Infections; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Macrophages; Methotrexate; Middle Aged; Pancytopenia; Sulfasalazine | 1998 |
Two different drug-induced pulmonary complications in a patient suffering from rheumatoid arthritis.
Topics: Aged; Aminorex; Antirheumatic Agents; Appetite Depressants; Arthritis, Rheumatoid; Cohort Studies; Contraindications; Humans; Hypertension, Pulmonary; Male; Methotrexate; Pneumonia | 1998 |
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, s
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Cyclosporine; Cytokines; Dexamethasone; DNA-Binding Proteins; Fibroblasts; Fluorescent Antibody Technique, Direct; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Methotrexate; Physical Stimulation; Synovial Membrane; Transcription Factors | 1998 |
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.
Topics: Adenosine; Apoptosis; Arthritis, Rheumatoid; Cell Cycle; Cells, Cultured; Clonal Deletion; Culture Media; Folic Acid Antagonists; Humans; Immunosuppressive Agents; Leukocytes, Mononuclear; Lymphocyte Activation; Methotrexate; Mitogens; Phytohemagglutinins; S Phase; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1998 |
Changing patterns in the use of slow acting antirheumatic drugs for the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Ambulatory Care; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Cohort Studies; Delayed-Action Preparations; Drug Utilization; Female; Humans; Male; Methotrexate; Middle Aged; New Zealand; Retrospective Studies; Treatment Outcome | 1998 |
Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule; Skin Diseases | 1998 |
HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Epitopes; Female; Histocompatibility Testing; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Patient Selection; Sulfasalazine; Treatment Outcome | 1998 |
Methotrexate treatment in Felty's syndrome.
Topics: Aged; Agranulocytosis; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Retrospective Studies; Splenomegaly; Syndrome | 1998 |
[Pneumocystis carinii pneumopathy in rheumatoid polyarthritis treated by methotrexate in a patient with pulmonary asbestosis].
Topics: Aged; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Asbestosis; Bronchoalveolar Lavage Fluid; Fatal Outcome; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Methotrexate; Opportunistic Infections; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole Drug Combination | 1998 |
Nephrotic syndrome following initiation of methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Nephrotic Syndrome | 1998 |
Depression and the long-term risk of pain, fatigue, and disability in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Depression; Disability Evaluation; Fatigue; Humans; Methotrexate; Pain; Prednisone; Risk Factors; Severity of Illness Index; Time Factors | 1998 |
[Basic therapeutics in the management of various forms of arthritis].
Topics: Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Humans; Methotrexate; Polymyalgia Rheumatica; Remission Induction; Spondylitis; Spondylitis, Ankylosing; Sulfasalazine | 1998 |
Severe hepatitis linked to B virus infection after withdrawal of low dose methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Male; Methotrexate; Prednisone | 1998 |
Multiple malignant melanomas in a patient with RA treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Melanoma; Methotrexate; Middle Aged; Skin Neoplasms | 1998 |
Cavitary lung tuberculosis in a rheumatoid arthritis patient treated with low-dose methotrexate and steroid pulse therapy.
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Methotrexate; Mycobacterium tuberculosis; Pregnenediones; Radiography; Sputum; Tuberculosis, Pulmonary | 1998 |
Urinary neopterin excretion and dihydropteridine reductase activity in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Dihydropteridine Reductase; Female; Gold Compounds; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Neopterin; Rheumatoid Factor; Sulfasalazine | 1998 |
Drug-combination therapy of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Cyclophosphamide; Cyclosporine; Disease Progression; Drug Therapy, Combination; Female; Fluocortolone; Glucocorticoids; Humans; Kidney; Longitudinal Studies; Male; Methotrexate; Middle Aged | 1998 |
Early effective suppression of inflammation in rheumatoid arthritis reduces radiographic progression.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Radiography; Risk Factors; Sulfasalazine | 1998 |
How Canadian and US rheumatologists treat moderate or aggressive rheumatoid arthritis: a survey.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Canada; Data Collection; Drug Prescriptions; Drug Therapy, Combination; Humans; Methotrexate; Practice Patterns, Physicians'; Rheumatology; Sulfasalazine; United States | 1998 |
Effects of long-term administration of methotrexate on bone mineral density in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Density; Female; Humans; Lumbar Vertebrae; Methotrexate; Middle Aged; Time Factors | 1999 |
Anticytokine therapy--a new era in the treatment of rheumatoid arthritis?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 1999 |
Methotrexate and radiographic disease progression in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Dose-Response Relationship, Drug; Humans; Methotrexate | 1999 |
Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.
Topics: Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cohort Studies; Collagenases; Cytokines; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methotrexate; Middle Aged; Rheumatoid Factor; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 1999 |
Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome | 1999 |
Safety of self-injection of gold and methotrexate.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Female; Gold Compounds; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Risk Assessment; Self Administration; Treatment Outcome | 1999 |
I have rheumatoid arthritis and have been taking methotrexate. I'm interested in the new drugs that have been in the news lately. Just how effective are they?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor | 1999 |
Human phaeohyphomycotic osteomyelitis caused by the coelomycete Phomopsis saccardo 1905: criteria for identification, case history, and therapy.
Topics: Arthritis, Rheumatoid; Ascomycota; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Methotrexate; Middle Aged; Mycoses; Osteomyelitis; Prednisone; Radiography | 1999 |
A case of pancytopenia secondary to low-dose pulse methotrexate therapy in a patient with rheumatoid arthritis and renal insufficiency.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Kidney Failure, Chronic; Methotrexate; Pancytopenia; Risk Factors | 1999 |
Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.
Topics: Amyloidosis; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Kidney Diseases; Methotrexate; Middle Aged; Nephrotic Syndrome; Prednisolone; Remission Induction | 1998 |
Validity of area-under-the-curve analysis to summarize effect in rheumatoid arthritis clinical trials.
Topics: Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Cyclosporine; Double-Blind Method; Drug Therapy, Combination; Evaluation Studies as Topic; Humans; Methotrexate; Prednisone; Randomized Controlled Trials as Topic; Reproducibility of Results; Rheumatology; Sulfasalazine; Treatment Outcome | 1999 |
An approach to preventing methotrexate prescribing errors in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Pharmacy Information Systems; Hospital Bed Capacity, 300 to 499; Humans; Massachusetts; Medication Errors; Methotrexate; Pharmacy Service, Hospital | 1993 |
Rheumatoid arthritis: new concepts in disease evolution, pathogenesis, and treatment.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Organogold Compounds; Treatment Outcome | 1995 |
Suppressive influences of methotrexate on the generation of CD14(+) monocyte-lineage cells from bone marrow of patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hematopoietic Stem Cells; HLA-DR Antigens; Humans; In Vitro Techniques; Inflammation Mediators; Lipopolysaccharide Receptors; Methotrexate; Middle Aged; Monocytes | 1999 |
Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone and Bones; Bone Resorption; Collagen; Collagen Type I; Evaluation Studies as Topic; Female; Humans; Joint Diseases; Male; Methotrexate; Middle Aged; Osteocalcin; Peptides; Steroids | 1999 |
[Methotrexate pneumonitis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Lung Diseases, Interstitial; Methotrexate; Radiography | 1999 |
Methotrexate-induced papular eruption in patients with rheumatic diseases: a distinctive adverse cutaneous reaction produced by methotrexate in patients with collagen vascular diseases.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen; Dermis; Diagnosis, Differential; Drug Eruptions; Female; Glucocorticoids; Histiocytes; Humans; Lupus Erythematosus, Systemic; Methotrexate; Middle Aged; Mixed Connective Tissue Disease; Neutrophils; Skin; Skin Diseases, Papulosquamous; Steroids | 1999 |
Lack of interaction between methotrexate and penicillins.
Topics: Arthritis, Rheumatoid; Drug Interactions; Floxacillin; Humans; Immunosuppressive Agents; Metabolic Clearance Rate; Methotrexate; Penicillins | 1999 |
Rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cyclooxygenase 2; Humans; Isoenzymes; Lymphocyte Subsets; Membrane Proteins; Methotrexate; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Synovial Membrane | 1999 |
Bibliography. Current world literature. Rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Cyclooxygenase 2; Humans; Isoenzymes; Membrane Proteins; Methotrexate; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Signal Transduction | 1999 |
Effects of methotrexate on cartilage metabolism.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cartilage, Articular; Humans; Methotrexate | 1999 |
Porphyria cutanea tarda affecting a rheumatoid arthritis patient treated with methotrexate: association or coincidence?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Liver; Methotrexate; Porphyria Cutanea Tarda | 1999 |
Allergic pancytopenia to trimethoprim-sulphamethoxazole for Pneumocystis carinii pneumonia following methotrexate treatment for rheumatoid arthritis.
Topics: Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Hypersensitivity; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole Drug Combination | 1999 |
Oral methotrexate: the hazard of different tablet strengths.
Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Patient Compliance; Tablets | 1999 |
Successful treatment of methotrexate induced nodulosis with D-penicillamine.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Penicillamine; Remission Induction; Rheumatoid Nodule | 1999 |
Severe pancytopenia caused by a single administration of low dose methotrexate in a patient undergoing hemodialysis.
Topics: Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Renal Dialysis | 1999 |
Etanercept in rheumatoid arthritis.
Topics: Activities of Daily Living; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 1999 |
Etanercept in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Receptors, Tumor Necrosis Factor | 1999 |
Combination therapy in rheumatoid arthritis: a comment.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine; Treatment Outcome | 1999 |
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Topics: Amidophosphoribosyltransferase; Arthritis, Rheumatoid; Bicarbonates; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Nucleotides; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Protein Biosynthesis; Proteins; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine | 1999 |
Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Lipopolysaccharide Receptors; Methotrexate; Monocytes; Receptors, Cell Surface; RNA; Synovial Membrane | 1999 |
Hodgkin's disease and B cell lymphoproliferation in rheumatoid arthritis patients treated with methotrexate: a kinetic study of lymph node changes.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged | 1999 |
Do infliximab and methotrexate act synergistically in the treatment of rheumatoid arthritis? Comment on the article by Maini et al.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Drug Synergism; Humans; Infliximab; Methotrexate; Tumor Necrosis Factor-alpha | 1999 |
Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity.
Topics: Adipokines; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Chitinase-3-Like Protein 1; Disease Progression; Female; Glycoproteins; Humans; Lectins; Male; Methotrexate; Middle Aged; Prednisolone; Severity of Illness Index | 1999 |
Rheumatoid nodules developing under methotrexate treatment for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Hand Dermatoses; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule | 1999 |
Treatment considerations in early rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclosporine; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Patient Selection; Risk; Sulfasalazine; Time Factors; Treatment Outcome | 1997 |
Combination therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Humans; Methotrexate | 1999 |
[Ulcerative stomatitis as clinical clue to inadvertent methotrexate overdose].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Medication Errors; Methotrexate; Mouth Mucosa; Oral Ulcer; Stomatitis | 1999 |
Angio-neurotic oedema associated with methotrexate treatment in rheumatoid arthritis.
Topics: Angioedema; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged | 1999 |
[Abdominal actinomycosis after stomach surgery in a patient with long-term rheumatoid arthritis treated with methotrexate].
Topics: Abdominal Abscess; Actinomycosis; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Diagnostic Imaging; Female; Gastrectomy; Humans; Methotrexate; Opportunistic Infections; Postgastrectomy Syndromes; Risk Factors; Stomach Ulcer | 1999 |
Flow cytometric detection of type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis, Atopic; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukin-5; Lymphocyte Count; Methotrexate; Middle Aged; T-Lymphocytes, Helper-Inducer | 1999 |
Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies; Time Factors | 1999 |
Paucity of radiographic progression in rheumatoid arthritis treated with methotrexate as the first disease modifying antirheumatic drug.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Humans; Methotrexate; Radiography | 1999 |
Tumour necrosis factor (TNF) production by T cell receptor-primed T lymphocytes is a target for low dose methotrexate in rheumatoid arthritis.
Topics: Adult; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma; Male; Methotrexate; Middle Aged; Monocytes; Receptors, Antigen, T-Cell; Synovial Membrane; T-Lymphocytes; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Colchicine therapy for low-dose-methotrexate-induced accelerated nodulosis in a rheumatoid arthritis patient.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy, Needle; Colchicine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Rheumatoid Nodule; Treatment Outcome | 1999 |
Disappointing longterm results with disease modifying antirheumatic drugs. A practice based study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Humans; Male; Methotrexate; Middle Aged; Multivariate Analysis; Retrospective Studies; Survival Analysis; Treatment Outcome | 1999 |
Elevation of serum hepatic aminotransferases during treatment of rheumatoid arthritis with low-dose methotrexate. Risk factors and response to folic acid.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Female; Folic Acid; Histamine H2 Antagonists; Humans; Liver; Male; Medical Records; Methotrexate; Middle Aged; Retrospective Studies | 1999 |
Rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aurothioglucose; Blood Loss, Surgical; Celecoxib; Dental Care for Chronically Ill; Humans; Methotrexate; Pyrazoles; Sjogren's Syndrome; Sulfonamides | 1999 |
Long-term application of disease modifying antirheumatic drugs (DMARD). A single-center, observational study of 1681 patients with rheumatoid arthritis (RA).
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Long-Term Care; Male; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Sulfasalazine; Treatment Outcome | 1999 |
Toxicity profile of methotrexate in rheumatoid arthritis. A preliminary survey.
Topics: Adult; Aged; Anemia, Macrocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Exanthema; Female; Folic Acid; Gastrointestinal Diseases; Health Care Surveys; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Pancytopenia; Patient Education as Topic; Patient Selection; Risk Factors | 1999 |
Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Nodule | 1999 |
Bone non-union after osteotomy in patients treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bony Callus; Contraindications; Humans; Male; Metatarsal Bones; Methotrexate; Middle Aged; Osteotomy; Radiography; Tibia; Treatment Outcome | 1999 |
Low-dose methotrexate in primary biliary cirrhosis.
Topics: Arthritis, Rheumatoid; Cholagogues and Choleretics; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Liver Cirrhosis, Biliary; Methotrexate; Ursodeoxycholic Acid | 1999 |
Safety of self-injection of gold and methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Gold Compounds; Humans; Methotrexate | 2000 |
Cyclosporine A pharmacokinetics in rheumatoid arthritis patients after 6 months of methotrexate therapy.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged | 1999 |
Hepatic fibrosis in rheumatoid arthritis patients treated with methotrexate: application of a new semi-quantitative scoring system.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Histological Techniques; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Transaminases | 2000 |
Epstein-Barr virus-associated Hodgkin's lymphoma and legionella pneumophila infection complicating treatment of juvenile rheumatoid arthritis with methotrexate and cyclosporine A.
Topics: Arthritis, Rheumatoid; Cyclosporine; Epstein-Barr Virus Infections; Fatal Outcome; Female; Hodgkin Disease; Humans; Immunosuppressive Agents; Infant; Legionnaires' Disease; Methotrexate | 2000 |
[Secondary amyloidosis in rheumatoid arthritis. A clinical study of 29 patients].
Topics: Adult; Aged; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Prognosis | 1999 |
The changing face of rheumatoid arthritis therapy: results of serial surveys.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Data Collection; Drug Therapy, Combination; Humans; Hydroxychloroquine; Methotrexate; Sulfasalazine | 2000 |
Methotrexate suppresses the interleukin-6 induced generation of reactive oxygen species in the synoviocytes of rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Gene Expression; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; Knee Joint; Methotrexate; Reactive Oxygen Species; RNA, Messenger; Synovial Fluid; Tumor Necrosis Factor-alpha | 2000 |
[New therapies in rheumatoid arthritis. Stopping joint deterioration].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Infliximab; Methotrexate; Prednisolone; Radiography; Treatment Outcome; Tumor Necrosis Factor-alpha | 2000 |
Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; CD4-Positive T-Lymphocytes; Cytokines; Flow Cytometry; Humans; Interleukin-10; Interleukin-4; Methotrexate; Prognosis; Prospective Studies; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha | 2000 |
[Pharmacotherapy of patients with (early) rheumatoid arthritis].
Topics: Agranulocytosis; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Humans; Methotrexate; Sulfasalazine | 2000 |
[Treatment of amyloidosis secondary to rheumatoid arthritis with methotrexate].
Topics: Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 2000 |
Factors influencing length of time taking methotrexate in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Life Tables; Male; Methotrexate; Middle Aged; Proportional Hazards Models | 2000 |
Rheumatoid arthritis in Sweden. Drug prescriptions, costs, and adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Costs; Drug Prescriptions; Humans; Methotrexate; Practice Patterns, Physicians'; Sweden | 2000 |
Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity.
Topics: Adult; Aged; Antirheumatic Agents; Arteriosclerosis; Arthritis, Rheumatoid; Comorbidity; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis | 2000 |
Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Skin Neoplasms | 2000 |
Methotrexate as a preferential cyclooxygenase 2 inhibitor in whole blood of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Isoenzymes; Male; Membrane Proteins; Methotrexate; Middle Aged; Prostaglandin-Endoperoxide Synthases | 2000 |
Immunoglobulin and lymphocyte decrease concurrent with adverse reactions induced by methotrexate for RA.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Immunoglobulins; Immunosuppressive Agents; Lymphocyte Count; Male; Methotrexate; Middle Aged | 2000 |
Drugs for rheumatoid arthritis.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Methotrexate; Nausea; Osteoporosis; Plasmapheresis; Prednisone; Sulfasalazine; Tumor Necrosis Factor-alpha | 2000 |
New gamma-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Folic Acid Antagonists; Glutamic Acid; Humans; Immunosuppressive Agents; Methotrexate; Mitogens; Molecular Structure; Pteridines; Pyrimidines; T-Lymphocytes | 2000 |
Increased MDR1 P-glycoprotein expression in methotrexate resistance: comment on the article by Yudoh et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cysteine; Drug Interactions; Drug Resistance, Multiple; Humans; Methotrexate; Sulfasalazine; Th1 Cells | 2000 |
Impotence in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Arthritis, Rheumatoid; Erectile Dysfunction; Genitalia, Male; Humans; Male; Methotrexate; Middle Aged | 2000 |
Low-dose methotrexate for the treatment of patients with large granular lymphocyte leukemia associated with rheumatoid arthritis.
Topics: Aged; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Leukemia, Myeloid; Leukocyte Count; Lymphocyte Count; Methotrexate; Middle Aged; Neutrophils; Retrospective Studies; Treatment Outcome | 2000 |
Leukemia of large granular lymphocytes and rheumatoid arthritis.
Topics: Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Follow-Up Studies; Humans; Leukemia, Myeloid; Methotrexate; Treatment Outcome | 2000 |
Reponse to methotrexate and reduced mortality in patients with rheumatoid arthritis: comment on the article by Krause et al.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Survival Rate | 2000 |
Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Community Medicine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Survival Analysis; Survival Rate; Time Factors; Treatment Outcome | 2000 |
Cutaneous ulcerations in a patient with rheumatoid arthritis receiving treatment with methotrexate.
Topics: Arthritis, Rheumatoid; Foot Ulcer; Humans; Male; Methotrexate; Middle Aged; Toes | 2000 |
Efficacy and safety of leflunomide in active rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2000 |
An Epstein-Barr virus-associated pulmonary lymphoproliferative disorder as complication of immunosuppression.
Topics: Arthritis, Rheumatoid; Biopsy, Needle; Epstein-Barr Virus Infections; Humans; Immunocompromised Host; Immunosuppressive Agents; Lung Neoplasms; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Risk Factors; Tomography, X-Ray Computed | 2000 |
[A case of rheumatoid arthritis associated with autoimmune hemolytic anemia due to weekly low-dose methotrexate therapy].
Topics: Anemia, Hemolytic, Autoimmune; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Methotrexate; Middle Aged; Prednisolone | 2000 |
Cyclosporin A inhibits CD69 expression induced on synovial fluid and peripheral blood lymphocytes by interleukin 15.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Arthritis, Rheumatoid; Cells, Cultured; Chemokines; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunosuppressive Agents; Interleukin-15; Lectins, C-Type; Lymphocyte Activation; Lymphocytes; Methotrexate; Synovial Fluid; Up-Regulation | 2000 |
Serious liver disease in a patient receiving methotrexate and leflunomide.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Severity of Illness Index | 2000 |
Folic acid supplementation and methotrexate efficacy: comment on articles by Schiff, Emery et al, and others.
Topics: Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Humans; Methotrexate; Therapeutic Equivalency | 2000 |
Safety of low dose methotrexate in elderly patients with rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Follow-Up Studies; Hemoglobins; Humans; Leukocyte Count; Male; Methotrexate; Retrospective Studies | 2000 |
Effects of combinations of anti-rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cells, Cultured; Cysteine; Dexamethasone; Drug Synergism; Drug Therapy, Combination; Endothelial Growth Factors; Fibroblast Growth Factor 2; Gold Sodium Thiomalate; Humans; In Vitro Techniques; Lipopolysaccharides; Lymphokines; Methotrexate; Sulfasalazine; Synovial Membrane; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Cell Differentiation; Cell Division; Cell Line; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Macrophages; Male; Methotrexate; Middle Aged; Monocytes; Myeloid Cells; Sialoglycoproteins; Synovial Membrane | 2000 |
[Submucous laryngeal space-occupying lesion. Methotrexate-induced development of a rheumatoid nodule in the larynx in primary chronic polyarthritis].
Topics: Arthritis, Rheumatoid; Female; Humans; Laryngeal Diseases; Methotrexate; Middle Aged; Rheumatoid Nodule | 2000 |
The national database of the German Collaborative Arthritis Centres: II. Treatment of patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Ambulatory Care; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Germany; Humans; Interprofessional Relations; Length of Stay; Male; Methotrexate; Middle Aged; Occupational Therapy; Patient Admission; Patient Education as Topic; Steroids | 2001 |
The other side of TNF-targeted therapy of patients with rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Humans; Infliximab; Japan; Methotrexate; Multicenter Studies as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2001 |
Epstein-Barr virus, methotrexate, and lymphoma in patients with rheumatoid arthritis and primary Sjögren's syndrome: case series.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Immunocompromised Host; In Situ Hybridization; Lymph Nodes; Lymphoma; Male; Methotrexate; Middle Aged; RNA, Viral; Sjogren's Syndrome | 2001 |
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atrial Fibrillation; Drug Therapy, Combination; Etanercept; Follow-Up Studies; Humans; Immunoglobulin G; Male; Methotrexate; Metoprolol; Middle Aged; Receptors, Tumor Necrosis Factor | 2000 |
Current management of rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Adult; Aged; Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Case Management; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged | 2001 |
Complications with low dose methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate | 1997 |
Development of fulminant hepatitis B (precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritis patient.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Genetic Variation; Hepatitis B; Hepatitis B virus; Humans; Methotrexate; Middle Aged; Mutation; Time Factors | 2001 |
[Cholesterol pericarditis associated with rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cholesterol; Female; Humans; Methotrexate; Pericardial Effusion; Pericarditis; Prednisolone | 2001 |
Methotrexate (MTX) inhibits osteoblastic differentiation in vitro: possible mechanism of MTX osteopathy.
Topics: Alkaline Phosphatase; Animals; Arthritis, Rheumatoid; Bone and Bones; Bone Marrow Cells; Calcification, Physiologic; Cell Differentiation; Dose-Response Relationship, Drug; Humans; Methotrexate; Mice; Osteoblasts; Tumor Cells, Cultured | 2001 |
Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clostridioides difficile; Drug Interactions; Enterocolitis, Pseudomembranous; Female; Humans; Methotrexate; Pancytopenia | 2001 |
Disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate | 1995 |
RA drug receives EU approval.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; European Union; Humans; Infliximab; Methotrexate | 2001 |
Is parenteral methotrexate worth trying?
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Cross-Sectional Studies; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Treatment Outcome | 2001 |
Late reactivation of spinal tuberculosis by low-dose methotrexate therapy in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Immunocompromised Host; Immunosuppression Therapy; Methotrexate; Middle Aged; Recurrence; Spine; Treatment Outcome; Tuberculosis, Spinal | 2001 |
The effective of methotrexate on immune response cells in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Humans; Immunity; Interleukin-1; Interleukin-6; Interleukin-8; Methotrexate | 2000 |
Enhanced in vitro induced production of interleukin 10 by peripheral blood mononuclear cells in rheumatoid arthritis is associated with clinical response to methotrexate treatment.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; In Vitro Techniques; Interleukin-10; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Retrospective Studies; Treatment Outcome | 2001 |
Cecal ulceration due to methotrexate.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Cecal Diseases; Colonoscopy; Female; Humans; Methotrexate; Ulcer | 2001 |
Amelioration of rat antigen-induced arthritis by liposomally conjugated methotrexate is accompanied by down-regulation of cytokine mRNA expression.
Topics: Animals; Antigens; Arthritis, Rheumatoid; Cytokines; Down-Regulation; Drug Carriers; Interleukin-1; Interleukin-6; Liposomes; Male; Methotrexate; Rats; Rats, Inbred Lew; RNA, Messenger; Tumor Necrosis Factor-alpha | 2001 |
Methotrexate osteopathy demonstrated by Technetium-99m HDP bone scintigraphy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Humans; Male; Methotrexate; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tibia | 2001 |
Treatment of Felty's syndrome with leflunomide.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged | 2001 |
Severe methotrexate intoxication in a haemodialysis patient treated for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Kidney Failure, Chronic; Methotrexate; Middle Aged; Renal Dialysis | 2001 |
The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Interleukin 1 Receptor Antagonist Protein; Methotrexate; Randomized Controlled Trials as Topic; Recombinant Proteins; Safety; Sialoglycoproteins; Treatment Outcome | 2001 |
Protective effect of folinic acid on low-dose methotrexate genotoxicity.
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Injections, Intraperitoneal; Leucovorin; Male; Methotrexate; Micronucleus Tests; Middle Aged; Rats; Rats, Wistar | 2001 |
[Methotrexate].
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 2001 |
Conventional DMARD options for patients with a suboptimal response to methotrexate.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Etanercept; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine | 2001 |
[Chronic polyarthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic; Sulfasalazine; Treatment Outcome | 2001 |
Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Homocysteine; Humans; Methotrexate; Myocardial Ischemia | 2001 |
Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive Agents; Leukemia, T-Cell; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Recurrence; Red-Cell Aplasia, Pure; Remission Induction; T-Lymphocytes, Cytotoxic | 2001 |
MTX affects inflammation and tissue destruction differently in the rat AA model.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Joints; Methotrexate; Rats; Rats, Inbred Lew | 2001 |
Re: Should methotrexate be stopped before surgery in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Preoperative Care | 2001 |
The HLA-DRB1*0401 allele and the development of methotrexate-induced accelerated rheumatoid nodulosis: a follow-up study of 79 Caucasian patients with rheumatoid arthritis.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Follow-Up Studies; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Nodule; White People | 2001 |
Alternatively spliced EDA-containing fibronectin in synovial fluid as a predictor of rheumatoid joint destruction.
Topics: Alternative Splicing; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Arthrography; Disease Progression; Ectodysplasins; Enzyme-Linked Immunosorbent Assay; Female; Fibronectins; Humans; Knee Joint; Male; Membrane Proteins; Methotrexate; Middle Aged; Prospective Studies; Severity of Illness Index; Synovial Fluid; Treatment Outcome | 2001 |
[Lymphedema of the upper limb, a complication of rheumatoid polyarthritis].
Topics: Antirheumatic Agents; Arm; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Lymphedema; Methotrexate; Middle Aged; Prednisone | 2001 |
Lymphoma in a patient with rheumatoid arthritis receiving methotrexate treatment: successful treatment with rituximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Immunocompromised Host; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Neoplasms, Second Primary; Rituximab; Treatment Outcome | 2001 |
Methotrexate inhibits rheumatoid synovitis by inducing apoptosis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Flow Cytometry; Humans; In Situ Nick-End Labeling; Male; Methotrexate; Mice; Mice, SCID; Microscopy, Electron; Synovial Membrane; Synovitis | 2001 |
New therapeutic approaches to the management of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Methotrexate; Receptors, Tumor Necrosis Factor; Staphylococcal Protein A; Tumor Necrosis Factor-alpha | 2001 |
[Leflunomide plus methotrexate. Hope for patients with rheumatoid arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Methotrexate | 2001 |
Is there a place for leflunomide in the treatment of rheumatoid arthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic | 2001 |
Acute myeloid leukemia in the setting of low dose weekly methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Bone Marrow; Drug Resistance, Multiple; Female; Humans; Immunophenotyping; Immunosuppressive Agents; In Situ Hybridization, Fluorescence; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Retrospective Studies | 2001 |
Leiomyosarcoma, rheumatoid arthritis and methotrexate: an association?
Topics: Aged; Arm; Arthritis, Rheumatoid; Bone Neoplasms; Fatal Outcome; Humans; Leiomyosarcoma; Lung Neoplasms; Male; Mediastinal Neoplasms; Methotrexate; Neoplasm Recurrence, Local | 2001 |
[Regression of Epstein-Barr virus associated lymphoma after methotrexate and cyclosporine A withdrawal in a patient with rheumathoid arthritis].
Topics: Arthritis, Rheumatoid; Cyclosporine; Epstein-Barr Virus Infections; Female; Humans; Immunosuppressive Agents; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged | 2001 |
Demonstration of response in rheumatoid arthritis patients who are nonresponders according to the American College of Rheumatology 20% criteria: the paradox of beneficial treatment effects in nonresponders in the ATTRACT trial. Anti-Tumor Necrosis Factor
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infliximab; Methotrexate; Prednisolone; Prognosis; Radiography; Severity of Illness Index; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2001 |
Leflunomide and rheumatoid arthritis: new preparation. Neither the safest nor the most effective slow-acting antirheumatic drug.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; France; Humans; Isoxazoles; Methotrexate; Treatment Outcome | 2001 |
Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Risk Factors | 2001 |
Discussion. Treatment algorithm: managing rheumatoid arthritis.
Topics: Algorithms; Antirheumatic Agents; Arthritis, Rheumatoid; Deductibles and Coinsurance; Disease Management; Drug Costs; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Medicare; Methotrexate; Patient Compliance; Primary Health Care; Quality of Life; Rheumatology; United States; Workforce | 2001 |
[Serious adverse effects of methotrexate therapy in patients with rheumatic arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Fatal Outcome; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Pneumonia | 1998 |
Intramuscular methotrexate in inflammatory rheumatic disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Intramuscular; Methotrexate; Patient Satisfaction | 2001 |
Eosinophilia as a side-effect of methotrexate in patients with chronic arthritis.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Child; Child, Preschool; Eosinophilia; Female; Humans; Male; Methotrexate; Middle Aged | 2001 |
The prevalence of rheumatoid arthritis in the general population of Spain.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Confidence Intervals; Female; Gold Compounds; Humans; Male; Methotrexate; Middle Aged; Odds Ratio; Population Surveillance; Prevalence; Probability; Prognosis; Risk Factors; Sampling Studies; Sex Distribution; Spain | 2002 |
Effective treatment of early rheumatoid arthritis with a combination of methotrexate, prednisolone and cyclosporin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Probability; Prognosis; Severity of Illness Index; Treatment Outcome | 2002 |
Severe pancytopenia associated with low-dose methotrexate therapy for rheumatoid arthritis.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Fatal Outcome; Female; Humans; Male; Methotrexate; Pancytopenia | 2001 |
Necrotising fasciitis in a patient receiving infliximab for rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Drug Eruptions; Drug Therapy, Combination; Fasciitis, Necrotizing; Fatal Outcome; Humans; Infliximab; Male; Methotrexate; Middle Aged | 2002 |
[IV: Small group workshop for developing future measures and projects. Evidence-based therapy in rheumatology with special reference to applications of new drugs--formulation of possible goals and possibilities for meeting them. Rheumatoid arthritis ].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Treatment Outcome | 2001 |
[Cytopenia associated with low dose pulse methotrexate in the treatment of rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Pancytopenia; Pulse Therapy, Drug; Thrombocytopenia | 2001 |
[Infliximab in aggressive and refractory rheumatoid arthritis. A pilot study].
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Infliximab; Male; Methotrexate; Middle Aged; Pilot Projects; Prednisone; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Second-line drugs used in recent-onset rheumatoid arthritis in Brittany (France).
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; France; Glucocorticoids; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Organogold Compounds; Rheumatology; Treatment Outcome | 2002 |
Should low-dose methotrexate therapy be prescribed to dialysis patients?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pancytopenia; Renal Dialysis; Uremia | 2002 |
Anticardiolipin antibodies in rheumatoid patients treated with etanercept or conventional combination therapy: direct and indirect evidence for a possible association with infections.
Topics: Adolescent; Adult; Aged; Antibodies, Anticardiolipin; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Child; Child, Preschool; Chloroquine; Cyclosporine; Drug Combinations; Etanercept; Humans; Immunoglobulin G; Immunoglobulin M; Infant; Infant, Newborn; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Staphylococcal Infections; Staphylococcus aureus | 2002 |
Methotrexate-induced nephrogenic diabetes insipidus: first case report.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Insipidus, Nephrogenic; Humans; Male; Methotrexate | 2002 |
[A case of rheumatoid arthritis complicated with a pneumonitis during concomitant treatment with methotrexate and bucillamine].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cysteine; Female; Humans; Methotrexate; Pneumonia | 2002 |
[A survey of the doses of methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Utilization; Drug Utilization Review; Humans; Methotrexate; Middle Aged; Sulfasalazine | 2002 |
Differing effects of methylenetetrahydrofolate reductase single nucleotide polymorphisms on methotrexate efficacy and toxicity in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genotype; Haplotypes; Humans; Japan; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Treatment Outcome | 2002 |
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Retrospective Studies; Treatment Outcome | 2002 |
[Skin nodules and ulcers of the limbs in a patient with rheumatoid arthritis].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Biopsy; Ciprofloxacin; Clarithromycin; Diagnosis, Differential; Drug Therapy, Combination; Ethambutol; Extremities; Glucocorticoids; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Prednisolone; Skin Diseases, Bacterial; Skin Ulcer; Vasculitis | 2002 |
Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Female; Humans; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Prospective Studies | 2002 |
Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Cyclosporine; Fibroblasts; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-17; Interleukin-8; Kinetics; MAP Kinase Signaling System; Methotrexate; NF-kappa B; Receptors, Interleukin; Receptors, Interleukin-17; Recombinant Proteins; RNA, Messenger; Signal Transduction; Synovial Membrane; Transcription, Genetic; U937 Cells | 2002 |
[Two fatal cases of methotrexate-induced interstitial pneumonitis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Fatal Outcome; Humans; Lung Diseases, Interstitial; Male; Methotrexate | 2002 |
[The effect of low dose methotrexate treatment on bone mineral density in patients with rheumatoid arthritis].
Topics: Absorptiometry, Photon; Adult; Arthritis, Rheumatoid; Bone Density; Female; Humans; Methotrexate; Osteoporosis; Sulfasalazine | 2002 |
Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; France; Hodgkin Disease; Humans; Incidence; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prospective Studies | 2002 |
Influence of steroids and methotrexate on wound complications after elective rheumatoid hand and wrist surgery.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Therapy, Combination; Elective Surgical Procedures; Female; Follow-Up Studies; Hand Deformities, Acquired; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Preoperative Care; Probability; Retrospective Studies; Risk Assessment; Surgical Wound Infection; Wrist Joint | 2002 |
Impact of leflunomide versus biologic agents on the costs of care for rheumatoid arthritis in a managed care population.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cost of Illness; Drug Costs; Etanercept; Female; Health Care Costs; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Male; Managed Care Programs; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Sulfasalazine; United States | 2002 |
Myelodysplasia revealed by seropositive polyarthritis complicated by bicytopenia after the first methotrexate dose.
Topics: Aged; Anemia; Arthritis, Rheumatoid; Fatal Outcome; Humans; Leukopenia; Male; Methotrexate; Myelodysplastic Syndromes; Rheumatoid Factor; Serologic Tests | 2002 |
Epstein-Barr virus-associated B-cell type non-Hodgkin's lymphoma with concurrent p53 protein expression in a rheumatoid arthritis patient treated with methotrexate.
Topics: Arthritis, Rheumatoid; DNA, Neoplasm; Epstein-Barr Virus Infections; Genome, Viral; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Tumor Suppressor Protein p53 | 2002 |
[Drug therapy and malpractice exemplified by combination leflunomide and methotrexate therapy].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Drug Interactions; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Malpractice; Methotrexate; Treatment Outcome | 2002 |
[Leflunomide + methotrexate combination therapy from the physician's viewpoint].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Approval; Drug Interactions; Drug Therapy, Combination; Germany; Humans; Isoxazoles; Leflunomide; Malpractice; Methotrexate | 2002 |
A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis.
Topics: Analysis of Variance; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Decision Making; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Pain Measurement; Probability; Prospective Studies; Receptors, Tumor Necrosis Factor; Sensitivity and Specificity; Sulfasalazine; Treatment Outcome; United States | 2002 |
[Changes in clinical and laboratory findings on oxidation metabolism in lymphocyte membranes of rheumatoid arthritis patients on synchronous programmed intensive therapy].
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Membrane; Female; Humans; Immunosuppressive Agents; Lipid Peroxidation; Lymphocytes; Male; Methotrexate; Methylprednisolone; Middle Aged | 2002 |
[TNF- alpha gene polymorphisms in rheumatoid arthritis patients treated with anti-TNF-alpha agents: preliminary results].
Topics: Adolescent; Adult; Aged; Alleles; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Drug Resistance; Female; Genotype; Humans; Infliximab; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2002 |
Methotrexate in the treatment of rheumatoid arthritis. I. In vitro effects on cells of the osteoblast lineage.
Topics: ADP-ribosyl Cyclase; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antigens, CD; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Bone Marrow Cells; Cell Count; Cell Division; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Female; GPI-Linked Proteins; Humans; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; Osteoblasts; Ribs; Stem Cells; Stromal Cells | 2002 |
Letter: Intra-articular methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Injections, Intra-Articular; Knee Joint; Male; Methotrexate; Middle Aged; Psoriasis | 1975 |
Arthritis due to Listeria monocytogenes.
Topics: Ampicillin; Arthritis, Infectious; Arthritis, Rheumatoid; Cephalothin; Drug Hypersensitivity; Female; Gentamicins; Humans; Knee Joint; Listeria monocytogenes; Listeriosis; Methotrexate; Middle Aged; Penicillin G | 1979 |
Introduction of antifolics in psoriasis. A twenty-five year retrospect of antineoplastic agents in nonmalignant disease.
Topics: Adult; Aminopterin; Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Male; Mechlorethamine; Methotrexate; Psoriasis; Retrospective Studies; Rheumatic Heart Disease | 1979 |
[Immunosuppressive drugs in rheumatic diseases (author's transl)].
Topics: Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate | 1979 |
[On the mode of action of antirheumatic drugs (author's transl)].
Topics: Antibiotics, Antineoplastic; Arthritis, Rheumatoid; Azathioprine; Chloroquine; Gold; Gold Sodium Thiosulfate; Humans; Methotrexate; Microsomes, Liver; Penicillamine | 1976 |
[Possibilities and limitations of immunosuppressive therapy (proceedings)].
Topics: Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate; Podophyllin; Triaziquone | 1976 |
[Antiinflammatory drugs--Use of cytostatic drugs in rheumatic diseases].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Methotrexate | 1975 |
Avascular necrosis of bone mimicking symmetric polyarthritis in a patient with malignant lymphoma treated with high-dose steroids.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Bleomycin; Cyclophosphamide; Diagnosis, Differential; Doxorubicin; Female; Humans; Lymphoma, Large-Cell, Immunoblastic; Methotrexate; Osteonecrosis; Prednisolone; Prednisone; Vincristine | 1992 |
Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pneumonia; Radiography | 1992 |
Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: II. Second line drugs and prednisone.
Topics: Age Factors; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Gold; Humans; Hydroxychloroquine; Long-Term Care; Methotrexate; Middle Aged; Penicillamine; Prednisone; Private Practice | 1992 |
Liver disease, erroneously attributed to methotrexate, in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Diagnostic Errors; Felty Syndrome; Humans; Male; Methotrexate | 1992 |
Methotrexate: clinical and immunological effects in refractory rheumatoid arthritis.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Blood Sedimentation; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Nausea; Prospective Studies; Remission Induction; Vomiting | 1992 |
Acute and chronic suppression of leukotriene B4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate.
Topics: Adult; Aged; Arachidonate 5-Lipoxygenase; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Humans; Leukotriene B4; Methotrexate; Middle Aged; Monocytes; Neutrophils; Time Factors | 1992 |
Effects of a single dose of methotrexate on 5- and 12-lipoxygenase products in patients with rheumatoid arthritis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Hydroxyeicosatetraenoic Acids; Injections, Intramuscular; Leukotriene B4; Male; Methotrexate; Middle Aged; Neutrophils; Time Factors | 1992 |
Pneumocystis carinii infection complicating cytotoxic therapy in two patients with lymphopenia, but a normal total white cell count.
Topics: Adult; Arthritis, Rheumatoid; Cyclophosphamide; Female; Humans; Leukocyte Count; Lymphocytes; Lymphopenia; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis; Polyarteritis Nodosa; Radiography, Thoracic | 1992 |
Liver enzyme levels in arthritis patients treated with long-term bolus methotrexate.
Topics: Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; gamma-Glutamyltransferase; Humans; Liver; Methotrexate; Time Factors | 1992 |
Benefit of G-CSF for methotrexate-induced neutropenia in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Neutropenia | 1992 |
Repetitive exercise induced ventricular tachycardia in a patient with rheumatoid arthritis taking low dose methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Exercise; Female; Humans; Methotrexate; Tachycardia | 1992 |
Pneumocystis carinii pneumonia following cyclosporine A and methotrexate treated rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Cyclosporine; Female; Humans; Methotrexate; Pneumonia, Pneumocystis | 1992 |
Methotrexate induced early onset pancytopenia in rheumatoid arthritis: drug allergy? Idiosyncrasy?
Topics: Aged; Arthritis, Rheumatoid; Drug Hypersensitivity; Female; Humans; Methotrexate; Middle Aged; Pancytopenia | 1992 |
Errors in prescribing methotrexate.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Drug Prescriptions; Humans; Medication Errors; Methotrexate | 1992 |
Does methotrexate retard radiologic progression of rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Arthrography; Humans; Joints; Methotrexate | 1992 |
[Gold therapy in chronic polyarthritis].
Topics: Arthritis, Rheumatoid; Gold; Humans; Injections, Intramuscular; Methotrexate; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors | 1992 |
Massive intrahepatic hemorrhage following routine liver biopsy in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Liver; Liver Diseases; Methotrexate | 1992 |
Recurrent episodes of pseudoseptic arthritis in rheumatoid arthritis: response to D-penicillamine and methotrexate.
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Penicillamine; Recurrence | 1992 |
Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate.
Topics: Anti-Inflammatory Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Gold Sodium Thiomalate; Humans; Immunoglobulin M; Interleukin-8; Methotrexate; Monocytes; Rheumatic Diseases; Rheumatoid Factor; Synovial Fluid | 1992 |
[A case of rheumatoid arthritis complicated with pseudotumor around odontoid process successfully treated by methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Odontoid Process; Spinal Diseases | 1992 |
Auranofin, methotrexate, but no placebo: comment on the article by Williams et al.
Topics: Arthritis, Rheumatoid; Auranofin; Humans; Methotrexate; Placebos | 1992 |
[The efficacy of basic therapy in rheumatoid arthritis with methotrexate].
Topics: Adult; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Time Factors | 1992 |
Sensitivity to change of the health assessment questionnaire (HAQ) and other clinical and health status measures in rheumatoid arthritis: results of short-term clinical trials and observational studies versus long-term observational studies.
Topics: Arthritis, Rheumatoid; Effect Modifier, Epidemiologic; Evaluation Studies as Topic; Female; Health Status; Humans; Kansas; Male; Methotrexate; Middle Aged; Research Design; Sensitivity and Specificity; Surveys and Questionnaires | 1992 |
Methotrexate in older patients with rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1992 |
[Regulations concerning low-dose treatment with cytostatics].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Methotrexate | 1992 |
Drug therapy in the rheumatic diseases.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Gold; Humans; Hydroxychloroquine; Lupus Erythematosus, Systemic; Methotrexate; Osteoarthritis; Penicillamine; Rheumatic Diseases | 1992 |
Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Remission Induction | 1992 |
[Effects of methotrexate on leukotriene and derivated lipoxygenase synthesis in polynuclear neutrophils in rheumatoid polyarthritis].
Topics: Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Female; Humans; Injections, Intramuscular; Leukotrienes; Lipoxygenase; Male; Methotrexate; Middle Aged; Neutrophils | 1992 |
[Nodular efflorescence and cutaneous vasculitis in rheumatoid arthritis treated with methotrexate].
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Vasculitis, Leukocytoclastic, Cutaneous | 1992 |
Methotrexate and non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Drug Interactions; Humans; Methotrexate | 1992 |
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis | 1992 |
Systemic rheumatoid vasculitis after discontinuation of methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Vasculitis | 1992 |
Methotrexate and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Glutathione; Humans; Methotrexate | 1992 |
Effects of copper supplementation on ceruloplasmin and copper-zinc superoxide dismutase in free-living rheumatoid arthritis patients.
Topics: Adult; Arthritis, Rheumatoid; Ceruloplasmin; Copper; Drug Therapy, Combination; Erythrocytes; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Orosomucoid; Superoxide Dismutase | 1992 |
Methotrexate pneumonitis in rheumatoid arthritis--a dramatic response to treatment.
Topics: Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Pneumonia | 1992 |
Methotrexate associated Peyronie's disease in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Penile Induration | 1992 |
Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis.
Topics: Absorption; Administration, Oral; Aged; Arthritis, Rheumatoid; Biological Availability; Dose-Response Relationship, Drug; Female; Food; Humans; Male; Methotrexate; Middle Aged | 1992 |
[Therapeutic maintenance dose with methotrexate in rheumatoid polyarthritis. Prospective study of 191 cases].
Topics: Adult; Aged; Analysis of Variance; Arthritis, Rheumatoid; Drug Tolerance; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1992 |
Life table analysis of 879 treatment episodes with slow acting antirheumatic drugs in community rheumatology practice.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Community Health Services; Female; Humans; Life Tables; Male; Methotrexate; Middle Aged; Time Factors | 1992 |
Use sensitivity in providing drug literature.
Topics: Arthritis, Rheumatoid; Drug Labeling; Female; Humans; Methotrexate; Patient Education as Topic | 1992 |
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Proteins; Choline; Female; Humans; Ibuprofen; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Protein Binding; Salicylates | 1992 |
Precision of the Larsen and the Sharp methods of assessing radiologic change in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Hand; Humans; Male; Methotrexate; Middle Aged; Observer Variation; Radiography; Sensitivity and Specificity; Wrist Joint | 1992 |
A debate: should patients with rheumatoid arthritis on methotrexate undergo liver biopsies?
Topics: Arthritis, Rheumatoid; Biopsy; Contraindications; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Methotrexate | 1992 |
Liver biopsies in patients with rheumatoid arthritis receiving methotrexate: where are we going?
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate | 1992 |
Clinical liver disease in patients with rheumatoid arthritis taking methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Humans; Incidence; Liver; Liver Cirrhosis; Liver Diseases; Methotrexate; Middle Aged; Obesity; Pulmonary Fibrosis | 1992 |
Drugs for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Azathioprine; Costs and Cost Analysis; Drugs, Investigational; Humans; Hydroxychloroquine; Methotrexate; Monitoring, Physiologic; Organogold Compounds; Penicillamine; Sulfasalazine | 1991 |
Highlights of the Eighth Annual Rheumatology on the Beach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Methotrexate; Osteoporosis; Rheumatology; United States | 1991 |
Do gold shots really work for rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Organogold Compounds | 1991 |
Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Female; Fibrosis; Humans; Image Interpretation, Computer-Assisted; Liver; Male; Methotrexate; Middle Aged; Polyglutamic Acid | 1991 |
Long-term prospective study of the use of methotrexate in the treatment of rheumatoid arthritis. Update after a mean of 90 months.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Pain; Prospective Studies; Pulmonary Fibrosis; Radiography; Treatment Outcome | 1992 |
Is the appearance of rheumatoid nodules in a rheumatoid patient well controlled on methotrexate an indication to stop the drug?
Topics: Arthritis, Rheumatoid; Contraindications; Humans; Methotrexate; Rheumatoid Nodule | 1992 |
Aspirin alters methotrexate disposition in rheumatoid arthritis patients.
Topics: Administration, Oral; Adult; Arthritis, Rheumatoid; Aspirin; Blood Proteins; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Protein Binding | 1991 |
Reconsideration of the risk of post-arthroplasty infection in patients treated with methotrexate.
Topics: Arthritis, Rheumatoid; Arthroplasty; Bacterial Infections; Humans; Methotrexate; Risk Factors | 1991 |
The place of methotrexate in the treatment of rheumatoid arthritis. Introduction.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Resistance; Humans; Methotrexate; Severity of Illness Index | 1991 |
Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Female; Humans; Lymphoma; Methotrexate; Middle Aged | 1991 |
[An unusual case of heavy gamma-chain disease with several monoclonal components: IgG kappa, IgM lambda, Bence-Jones proteins kappa and lambda].
Topics: Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Azathioprine; Bence Jones Protein; Combined Modality Therapy; Electrophoresis, Agar Gel; Female; Heavy Chain Disease; Humans; Immunoelectrophoresis; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Lymphatic Diseases; Methotrexate; Middle Aged; Prednisolone; Splenectomy; Vincristine | 1991 |
Study of DNA repair in the peripheral blood lymphocytes of patients with rheumatic diseases under going treatment.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Azathioprine; DNA Repair; Humans; Lupus Erythematosus, Systemic; Lymphocytes; Methotrexate; Middle Aged; Prospidium; Reference Values | 1991 |
Methotrexate-induced bone-marrow suppression.
Topics: Aged; Arthritis, Rheumatoid; Carcinoma, Transitional Cell; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Urinary Bladder Neoplasms | 1991 |
Delayed methotrexate pneumonitis.
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pneumonia | 1991 |
Low dose MTX and NSAID induced "mild" renal insufficiency and severe neutropenia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Methotrexate; Middle Aged; Neutropenia | 1991 |
[Rheumatoid arthritis treated with methotrexate. Study of 67 patients].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1991 |
Cytomegalovirus pneumonia in a patient with rheumatoid arthritis treated with low dose methotrexate and prednisone.
Topics: Arthritis, Rheumatoid; Cytomegalovirus Infections; Humans; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Viral; Prednisolone | 1991 |
Low-dose methotrexate and cholangiocarcinoma of the common hepatic duct.
Topics: Adenoma, Bile Duct; Arthritis, Rheumatoid; Bile Duct Neoplasms; Hepatic Duct, Common; Humans; Male; Methotrexate; Middle Aged | 1991 |
Nocardia asteroides infection complicating rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Lung Diseases; Methotrexate; Middle Aged; Nocardia Infections; Prednisone | 1991 |
Concurrent use of folinic acid and MTX in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Leucovorin; Methotrexate | 1991 |
Changes in the marketing of methotrexate.
Topics: Arthritis, Rheumatoid; Drug Packaging; Humans; Marketing of Health Services; Methotrexate | 1991 |
Two methods of assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Collagen; Female; Histological Techniques; Humans; Image Interpretation, Computer-Assisted; Liver; Male; Methotrexate; Middle Aged | 1991 |
The effect of age on methotrexate efficacy and toxicity.
Topics: Adult; Aged; Aging; Arthritis, Rheumatoid; Creatinine; Humans; Leukocyte Count; Methotrexate; Middle Aged | 1991 |
Should methotrexate be discontinued before elective orthopedic surgery in patients with rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Follow-Up Studies; Humans; Joint Prosthesis; Methotrexate; Patient Satisfaction; Postoperative Complications; Preoperative Care | 1991 |
Low-dose methotrexate therapy and hepatotoxicity. The view of the hepatologist.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1991 |
Neutropenia due to low-dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Penicillins; Psoriasis; Retrospective Studies | 1991 |
Pancytopenia after accidental overdose of methotrexate. A complication of low-dose therapy for rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Overdose; Female; Humans; Medication Errors; Methotrexate; Pancytopenia | 1991 |
[Immunogenetic prognosis of the effectiveness of cytostatic therapy of rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Cyclophosphamide; Drug Evaluation; Female; HLA-DR Antigens; Humans; In Vitro Techniques; Lymphocytes; Methotrexate; Middle Aged; Prospidium | 1991 |
Methotrexate and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Humans; Methotrexate; Research Design | 1991 |
Nocardia asteroides pneumonia complicating low dose methotrexate treatment of refractory rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Nocardia asteroides; Nocardia Infections; Opportunistic Infections; Pancytopenia; Pleurisy; Pneumonia | 1991 |
Retardation of radiologic progression in rheumatoid arthritis with methotrexate therapy. A controlled study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Arthrography; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1991 |
Effect of medication on synovial fluid leukocyte differentials in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Gold; Humans; Hydroxychloroquine; Leukocytes; Male; Methotrexate; Synovial Fluid | 1991 |
Complications of immunosuppression associated with weekly low dose methotrexate.
Topics: Aged; Aged, 80 and over; Arthritis, Psoriatic; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Herpes Zoster; Humans; Immunosuppression Therapy; Incidence; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Pneumonia, Pneumocystis | 1991 |
[Evaluation of rheumatoid arthritis treatment with methotrexate by survival analysis].
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis | 1991 |
[Pancytopenia and opportunistic infections in rheumatoid arthritis treated with methotrexate].
Topics: Adrenal Gland Diseases; Aged; Arthritis, Rheumatoid; Aspergillosis; Cytomegalovirus Infections; Female; Humans; Lung Diseases, Fungal; Methotrexate; Opportunistic Infections; Pancytopenia | 1990 |
[New principle of the treatment of rheumatoid arthritis: combined basic therapy].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Penicillamine; Rheumatology; Sulfasalazine | 1990 |
[Interstitial lung disease in rheumatoid arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; Female; Humans; Male; Methotrexate; Middle Aged; Organogold Compounds; Penicillamine; Prednisolone; Prognosis; Pulmonary Fibrosis; Respiratory Function Tests | 1990 |
Response of immunoregulatory lymphocyte subsets to methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Female; Humans; Male; Methotrexate; T-Lymphocytes, Regulatory | 1990 |
Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14-year prospective evaluation of 1017 consecutive starts.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Penicillamine; Prognosis; Prospective Studies; Regression Analysis; Time Factors | 1990 |
[Maintenance treatments of rheumatoid arthritis].
Topics: Antimalarials; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Organogold Compounds; Penicillamine | 1990 |
Effects of methotrexate on clinical and immunological parameters in refractory rheumatoid arthritis: a prospective study.
Topics: Arthritis, Rheumatoid; Humans; Immunoglobulins; Methotrexate; Pain; Prospective Studies; Severity of Illness Index | 1991 |
Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Incidence; Knee Prosthesis; Male; Methotrexate; Middle Aged; Prednisone; Reoperation; Retrospective Studies; Surgical Wound Dehiscence; Surgical Wound Infection | 1991 |
Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Fibrosis; HLA-DR Antigens; Humans; Immunohistochemistry; Methotrexate; Osteoarthritis; Prednisone; Receptors, Interleukin-2; Synovial Membrane; T-Lymphocyte Subsets | 1991 |
Methotrexate for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1991 |
Herpes zoster in patients with rheumatoid arthritis treated with weekly, low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Female; Herpes Zoster; Humans; Incidence; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies | 1991 |
Delayed methotrexate pneumonitis in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Middle Aged; Pulmonary Fibrosis; Time Factors | 1991 |
[Dyspnea during administration of methotrexate: not anything to treat casually].
Topics: Aged; Arthritis, Rheumatoid; Combined Modality Therapy; Dyspnea; Female; Humans; Methotrexate; Middle Aged; Pneumonia | 1991 |
Severe pancytopenia in a patient taking low dose methotrexate and probenecid.
Topics: Aged; Arthritis, Rheumatoid; Blood Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Methotrexate; Pancytopenia; Probenecid | 1991 |
Folate supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Blood Cell Count; Creatinine; Drug Therapy, Combination; Folic Acid; Gastrointestinal Diseases; Humans; Methotrexate | 1991 |
Activated lymphocytes in peripheral blood of patients with RA.
Topics: Arthritis, Rheumatoid; Humans; Lymphocyte Activation; Methotrexate | 1990 |
[Production of interleukin 2 and interferon-gamma in rheumatoid polyarthritis during a longitudinal study conducted on patients treated with methotrexate].
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Interferon-gamma; Interleukin-2; Longitudinal Studies; Male; Methotrexate; Middle Aged | 1990 |
Toxic response to topical fluorouracil in two rheumatoid arthritis patients receiving low-dose, weekly methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Drug Eruptions; Drug Synergism; Fluorouracil; Humans; Keratosis; Male; Methotrexate; Middle Aged; Ointments; Time Factors | 1990 |
Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate.
Topics: Aged; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Calcimycin; Chemotaxis, Leukocyte; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Methotrexate; Middle Aged; Neutrophils; Phospholipases; Platelet Activating Factor | 1990 |
Combination D-penicillamine and methotrexate therapy: proposal for early and aggressive treatment for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Penicillamine; Retrospective Studies | 1990 |
Methotrexate hepatotoxicity and the premature reporting of Mark Twain's death: both greatly exaggerated.
Topics: Arthritis, Rheumatoid; Biopsy; Humans; Liver; Liver Cirrhosis; Methotrexate | 1990 |
Methotrexate induced pneumonitis in a young woman with psoriasis and rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lung; Methotrexate; Psoriasis; Pulmonary Fibrosis | 1990 |
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; Ibuprofen; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1990 |
Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination.
Topics: Aged; Arthritis, Rheumatoid; Drug Synergism; Drug Therapy, Combination; Female; Humans; Leg Ulcer; Methotrexate; Pancytopenia; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections | 1990 |
[Low dose methotrexate therapy in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1990 |
Methotrexate, liver abnormalities and RA.
Topics: Arthritis, Rheumatoid; Humans; Liver; Methotrexate | 1990 |
Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation.
Topics: Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; Humans; Lectins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Thymidine; Tritium | 1990 |
Methotrexate therapy in rheumatoid arthritis. A two year prospective follow-up.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Female; Follow-Up Studies; Humans; Liver; Male; Methotrexate; Middle Aged; Prospective Studies | 1990 |
Can treatment with methotrexate influence the radiological progression of rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Hand; Humans; Methotrexate; Radiography; Retrospective Studies | 1990 |
Effect of aspirin and sulindac on methotrexate clearance.
Topics: Arthritis, Rheumatoid; Aspirin; Drug Interactions; Female; Humans; Male; Methotrexate; Sulindac | 1990 |
How we got to be where we are.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Europe; Gold; History, 20th Century; Humans; Methotrexate; Rheumatology; United States | 1990 |
Challenging the therapeutic pyramid: a new look at treatment strategies for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Prednisolone; Rheumatology | 1990 |
[Megaloblastic pancytopenia in a female patient with rheumatoid arthritis given methotrexate and amidopyrine simultaneously].
Topics: Acute Disease; Aminopyrine; Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Humans; Megaloblasts; Methotrexate; Middle Aged; Pancytopenia | 1990 |
Achieving consensus on an algorithm for the treatment of rheumatoid arthritis with methotrexate.
Topics: Algorithms; Arthritis, Rheumatoid; Clinical Protocols; Humans; Methotrexate; Practice Patterns, Physicians'; Rheumatology | 1990 |
Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Humans; Injections, Intramuscular; Injections, Subcutaneous; Methotrexate; Middle Aged; Osmolar Concentration; Statistics as Topic | 1990 |
Regarding methotrexate pricing.
Topics: Arthritis, Rheumatoid; Costs and Cost Analysis; Drug Therapy; Humans; Methotrexate | 1990 |
Methotrexate and liver biopsies. Is it really necessary?
Topics: Arthritis, Rheumatoid; Biopsy; Humans; Liver; Liver Cirrhosis; Methotrexate; Psoriasis | 1990 |
Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis.
Topics: Absorption; Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Drug Therapy, Combination; Humans; Injections, Intravenous; Kidney; Metabolic Clearance Rate; Methotrexate; Middle Aged; Naproxen; Protein Binding | 1990 |
Rheumatoid arthritis, methotrexate therapy, and Pneumocystis pneumonia.
Topics: Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pneumonia, Pneumocystis | 1990 |
[What is your diagnosis? pneumonitis in relation to methotrexate therapy].
Topics: Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pneumonia | 1990 |
[Bone marrow aplasia in rheumatoid polyarthritis treated with low-dose methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pancytopenia | 1990 |
Methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Liver; Methotrexate | 1990 |
Treatment of rheumatoid arthritis with higher dose intravenous methotrexate.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Evaluation; Drug Resistance; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged | 1990 |
Low-dose methotrexate: anti-inflammatory or immunosuppressive?
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1990 |
Biliary elimination of low-dose methotrexate in humans.
Topics: Arthritis, Rheumatoid; Bile; Biological Availability; Drug Administration Schedule; Humans; Male; Methotrexate; Middle Aged; Osmolar Concentration | 1990 |
[Pneumonitis as a complication of low-dose methotrexate therapy in chronic polyarthritis].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Male; Methotrexate; Middle Aged; Pulmonary Fibrosis | 1990 |
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.
Topics: Arthritis, Rheumatoid; Female; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Methotrexate; Middle Aged; Necrosis | 1990 |
[Pulmonary disease induced by methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Lung Diseases; Male; Methotrexate; Pneumonia | 1990 |
Early beneficial effects of low dose oral methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1990 |
Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression.
Topics: Arthritis, Rheumatoid; Humans; Immunoglobulin A; Immunoglobulin M; Methotrexate; Rheumatoid Factor | 1990 |
[The comparative efficacy of reaferon and methotrexate in rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Drug Evaluation; Drug Therapy, Combination; Humans; Immunity, Cellular; Interferon alpha-2; Interferon Type I; Interferon-alpha; Methotrexate; Recombinant Proteins; T-Lymphocytes; Time Factors | 1990 |
Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Time Factors | 1990 |
Comment on the article by Morgan et al.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate | 1990 |
Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates.
Topics: Arthritis, Rheumatoid; Biopsy; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Liver; Methotrexate; Osmolar Concentration; Peptide Biosynthesis; Polyglutamic Acid | 1986 |
Liver biopsy findings in patients with rheumatoid arthritis undergoing longterm treatment with methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Collagen; Female; Fibrosis; Humans; Liver; Male; Methotrexate; Middle Aged; Staining and Labeling; Time Factors | 1989 |
Short term effects of low dose methotrexate on the acute phase reaction in patients with rheumatoid arthritis.
Topics: Acute-Phase Reaction; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Drug Administration Schedule; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Time Factors | 1989 |
Felty's syndrome: response to low dose oral methotrexate.
Topics: Administration, Oral; Arthritis, Rheumatoid; Drug Resistance; Felty Syndrome; Female; Gold; Humans; Lithium; Lithium Carbonate; Methotrexate; Middle Aged | 1989 |
Methotrexate serum-level determinations during low-dose therapy of rheumatoid and psoriatic arthritis.
Topics: Arthritis, Rheumatoid; C-Reactive Protein; Electron Spin Resonance Spectroscopy; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Psoriasis | 1989 |
Drugs for rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Gold; Humans; Hydroxychloroquine; Methotrexate; Penicillamine; Salicylates; Sulfasalazine | 1989 |
Combination methotrexate and sulfasalazine in the management of rheumatoid arthritis: case observations.
Topics: Aged; Arthritis, Rheumatoid; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Sulfasalazine; Time Factors | 1989 |
Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Ascites; Chemical and Drug Induced Liver Injury, Chronic; Fatty Liver; Female; Hepatitis, Chronic; Humans; Liver Cirrhosis; Methotrexate; Middle Aged | 1989 |
Methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1989 |
[Pancytopenia during rheumatoid polyarthritis treated by low doses of methotrexate].
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pancytopenia | 1989 |
Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy.
Topics: Aged; Arthritis, Rheumatoid; Blood; Blood Cell Count; Female; Forecasting; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis | 1989 |
Methotrexate in the treatment of vasculitic cutaneous ulceration in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Leg Ulcer; Methotrexate; Middle Aged; Vasculitis | 1989 |
Methotrexate in rheumatoid arthritis: studies with animal models.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Histocompatibility Antigens Class II; Interleukin-1; Interleukin-2; Male; Methotrexate; Neutrophils; Rats; Rats, Inbred Lew; Spleen | 1989 |
Drug therapy in rheumatoid arthritis--a perspective.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Methotrexate; Peptide Fragments; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Remission Induction; Thymopentin; Thymopoietins | 1989 |
Methotrexate pharmacokinetics in patients with rheumatoid arthritis.
Topics: Administration, Oral; Adult; Antimetabolites; Arthritis, Rheumatoid; Female; Fluorescent Antibody Technique; Humans; Male; Methotrexate; Middle Aged | 1989 |
Prospective long term follow-up of methotrexate therapy in rheumatoid arthritis: toxicity, efficacy and radiological progression.
Topics: Aged; Arthritis, Rheumatoid; Blood Cell Count; Follow-Up Studies; Hematologic Diseases; Humans; Methotrexate; Middle Aged; Prospective Studies; Radiography; Severity of Illness Index; Time Factors | 1989 |
Rheumatology.
Topics: Arthritis, Rheumatoid; Central Nervous System Diseases; Gout; Humans; Methotrexate; Rheumatology; Sjogren's Syndrome | 1989 |
Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Half-Life; Humans; Injections, Intravenous; Joints; Methotrexate; Middle Aged | 1989 |
Methotrexate 1989--the evolving story.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1989 |
Methotrexate therapy in rheumatoid arthritis: 2-year retrospective followup study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 1989 |
Rheumatoid pancarditis in a patient with well controlled rheumatoid arthritis.
Topics: Arteritis; Arthritis, Rheumatoid; Heart Block; Heart Conduction System; Heart Valve Diseases; Humans; Male; Methotrexate; Middle Aged; Myocarditis; Pericarditis; Rheumatoid Nodule | 1989 |
Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Pancytopenia; Time Factors | 1989 |
Intractable RA--treatment with combined methotrexate, azathioprine and hydroxychloroquine.
Topics: Adult; Arthritis, Rheumatoid; Azathioprine; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Methotrexate; Middle Aged | 1989 |
Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatment.
Topics: Age Factors; Aged; Arthritis, Rheumatoid; Biopsy; Black People; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Sex Factors; Statistics as Topic; Time Factors; White People | 1989 |
Central nervous system toxicity associated with weekly low-dose methotrexate treatment.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Brain; Creatinine; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1989 |
[Methotrexate (MTX) in the treatment of rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged | 1989 |
A patient with seropositive rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Methotrexate; Time Factors | 1989 |
Intrarticular methotrexate in the therapy of rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Injections, Intra-Articular; Knee Joint; Male; Metalloproteins; Methotrexate; Middle Aged | 1989 |
Physician compensation for drug surveys.
Topics: Arthritis, Rheumatoid; Drug Evaluation; Drug Industry; Ethics, Pharmacy; Humans; Methotrexate; Patient Compliance | 1989 |
Severe reversible interstitial pneumonitis induced by low dose methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Pulmonary Fibrosis | 1989 |
Prospective analysis of liver biopsies before and after methotrexate therapy in rheumatoid patients.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Longitudinal Studies; Male; Methotrexate; Middle Aged; Peritonitis; Prospective Studies | 1989 |
Synovial and serum levels of methotrexate during methotrexate therapy of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Injections, Intravenous; Methotrexate; Synovial Fluid | 1989 |
Methotrexate--its current use in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1989 |
Methotrexate treatment of rheumatoid arthritis: effects on radiological progression.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Radiography; Retrospective Studies | 1989 |
[Severe acute pneumopathy following low-dose methotrexate therapy in chronic polyarthritis].
Topics: Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Methylprednisolone; Pneumonia; Radiography; Respiration, Artificial | 1989 |
Methotrexate-induced pneumonitis: appearance four weeks after discontinuation of treatment.
Topics: Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Pulmonary Fibrosis; Time Factors | 1989 |
Electron microscopic analysis of sequential liver biopsy samples from patients with rheumatoid arthritis. Correlation with light microscopic findings.
Topics: Arthritis, Rheumatoid; Biopsy; Collagen; HLA Antigens; Humans; Liver; Methotrexate; Microscopy, Electron; Prospective Studies; Time Factors | 1989 |
Impotence in three rheumatoid arthritis patients treated with methotrexate.
Topics: Arthritis, Rheumatoid; Erectile Dysfunction; Humans; Male; Methotrexate; Middle Aged | 1989 |
Low-dose methotrexate treatment of rheumatoid arthritis; long-term observation of efficacy and safety.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction | 1989 |
Eruption of nodulosis and vasculitis during methotrexate therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Foot; Humans; Male; Methotrexate; Middle Aged; Rheumatoid Nodule; Spine; Vasculitis | 1989 |
Fatal interaction between methotrexate and naproxen.
Topics: Arthritis, Rheumatoid; Drug Interactions; Drug Therapy, Combination; Female; Humans; Methotrexate; Naproxen | 1986 |
Slow-acting anti-rheumatic drug therapy for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Gold; Humans; Hydroxychloroquine; Methotrexate; Penicillamine; Sulfasalazine | 1987 |
Combination chemotherapy in rheumatoid arthritis.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine | 1987 |
Advances in the drug management of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Methotrexate; Sulfasalazine | 1988 |
[Treatment of rheumatoid arthritis: drugs which induce remission].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Cyclosporins; Humans; Methotrexate; Organogold Compounds; Penicillamine | 1988 |
Methotrexate and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Humans; Methotrexate | 1989 |
Folic acid treatment in methotrexate-treated rheumatoid arthritis patients: comment on the article by Furst and Kremer.
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 1989 |
Methotrexate therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 1989 |
Toxicity of methotrexate compared with azathioprine in the treatment of rheumatoid arthritis. A case-control study of 131 patients.
Topics: Actuarial Analysis; Arthritis, Rheumatoid; Azathioprine; Blood Urea Nitrogen; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Risk Factors; Time Factors | 1989 |
Liver histology in rheumatoid arthritis patients receiving long-term methotrexate therapy. A prospective study with baseline and sequential biopsy samples.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors | 1989 |
[Pancytopenia during treatment of rheumatoid arthritis with methotrexate after administration of trimethoprim-sulfamethoxazole].
Topics: Anti-Infective Agents; Arthritis, Rheumatoid; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Pancytopenia; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1987 |
Methotrexate in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Eruptions; Gastrointestinal Diseases; Humans; Immunosuppressive Agents; Lung Diseases; Methotrexate; Stomatitis; Teratogens | 1988 |
In vivo effects of antirheumatic drugs on neutral collagenolytic proteases in human rheumatoid arthritis cartilage and synovium.
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular; Collagen; DNA; Gold; Humans; Methotrexate; Middle Aged; Peptide Hydrolases; Serine Endopeptidases; Steroids; Synovial Membrane | 1988 |
Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.
Topics: Adult; Arthritis, Rheumatoid; Diet; Erythrocytes; Female; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Serine; Vitamins | 1987 |
[Blood cell concentration of methotrexate in long-term therapy of inflammatory rheumatic diseases].
Topics: Adult; Aged; Arthritis; Arthritis, Rheumatoid; Erythrocytes; Female; Humans; Long-Term Care; Male; Methotrexate; Middle Aged; Psoriasis | 1988 |
[Long-term course of chronic polyarthritis under basic medication].
Topics: Arthritis, Rheumatoid; Follow-Up Studies; Gold; Humans; Methotrexate; Radiography; Time Factors | 1988 |
[Low-dose oral methotrexate in the treatment of rheumatoid polyarthritis].
Topics: Adult; Aged; Alopecia; Arthritis, Rheumatoid; Blood Sedimentation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Time Factors | 1988 |
Methotrexate may help arthritis.
Topics: Arthritis, Rheumatoid; Humans; Liver; Methotrexate | 1988 |
Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis.
Topics: Aged; Arthritis; Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk Factors | 1988 |
Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-term bolus methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Time Factors | 1988 |
Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Collagen; Female; Humans; Liver; Liver Diseases; Lysosomes; Male; Methotrexate; Microscopy; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Prospective Studies | 1988 |
Comment on the letter by Jaffe.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1988 |
Fatal methotrexate pneumonitis in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pulmonary Fibrosis | 1988 |
Methotrexate-associated bone marrow suppression following surgery.
Topics: Aged; Arthritis, Rheumatoid; Bone Marrow Diseases; Humans; Male; Methotrexate; Postoperative Complications | 1988 |
Methotrexate kinetics in rheumatoid arthritis: is there an interaction with nonsteroidal antiinflammatory drugs?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Availability; Creatinine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged | 1988 |
Nocardiosis associated with low dose methotrexate for rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Nocardia Infections; Opportunistic Infections | 1988 |
Severe bone marrow failure due to low dose oral methotrexate.
Topics: Acute Disease; Administration, Oral; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Middle Aged; Myelodysplastic Syndromes | 1988 |
Low dose methotrexate and acute respiratory insufficiency.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Respiratory Insufficiency | 1988 |
Pancytopenia induced by low-dose methotrexate for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Male; Methotrexate; Pancytopenia; Risk Factors | 1988 |
Methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1988 |
High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; HLA-DR Antigens; Humans; Injections, Intravenous; Leucovorin; Methotrexate; Pain; Pilot Projects; Recurrence; T-Lymphocytes | 1988 |
The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Drug Synergism; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Middle Aged | 1988 |
Variability of methotrexate pharmacokinetics and pharmacodynamics.
Topics: Administration, Oral; Arthritis, Rheumatoid; Biological Availability; Bone Marrow; Humans; Liver; Lung; Methotrexate; Stomatitis | 1988 |
Beneficial effects of leucovorin after methotrexate treatment in rheumatoid arthritis: a case report.
Topics: Arthritis, Rheumatoid; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Stomatitis | 1988 |
Methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Arthrography; Humans; Methotrexate; Middle Aged | 1988 |
On the treatment of rheumatoid arthritis with M&Ms (Motrin & methotrexate)
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Ibuprofen; Methotrexate | 1988 |
Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Female; Humans; In Vitro Techniques; Male; Methotrexate; Middle Aged; Neutrophils; Time Factors | 1988 |
Pulse methotrexate therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate; Radiography; Research Design | 1988 |
[Treatment of chronic polyarthritis with low-dose methotrexate].
Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Arthritis, Rheumatoid; Chloroquine; Drug Evaluation; Drug Therapy, Combination; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Penicillamine; Time Factors | 1988 |
The place of cyclosporine A in the treatment of connective tissue diseases.
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Connective Tissue Diseases; Cyclosporins; Drug Evaluation; Drug Therapy, Combination; Female; Fluocortolone; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Pilot Projects | 1988 |
Clearer picture emerging of methotrexate role as part of rheumatoid arthritis treatment.
Topics: Arthritis, Rheumatoid; Humans; Liver Cirrhosis; Methotrexate | 1988 |
Methotrexate in rheumatoid arthritis: a prospective study in Israeli patients with immunogenetic correlations.
Topics: Aged; Arthritis, Rheumatoid; Female; HLA Antigens; Humans; Israel; Male; Methotrexate; Middle Aged; Prospective Studies | 1988 |
Methotrexate in refractory rheumatoid arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; C-Reactive Protein; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Methotrexate; Middle Aged | 1988 |
[Severe complications in the use of a minimal dose of methotrexate].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged | 1988 |
Accelerated nodulosis and vasculitis during methotrexate therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Middle Aged; Raynaud Disease; Rheumatoid Nodule; Skin; Time Factors; Vasculitis | 1988 |
Oral methotrexate in the treatment of rheumatoid arthritis: allergic agranulocytosis?
Topics: Agranulocytosis; Arthritis, Rheumatoid; Drug Hypersensitivity; Humans; Male; Methotrexate; Middle Aged | 1987 |
Low dose pulse methotrexate in rheumatoid arthritis: an 8-year experience with hepatotoxicity.
Topics: Adult; Age Factors; Aged; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Serum Albumin; Sex Factors; Transaminases | 1987 |
Severe oral ulceration in a patient taking low-dose methotrexate for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Mouth Diseases; Ulcer | 1986 |
DR2 positivity and response to methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Histocompatibility Antigens Class II; HLA-DR2 Antigen; Humans; Methotrexate | 1986 |
Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole.
Topics: Arthritis, Rheumatoid; Bone Marrow Diseases; Drug Combinations; Drug Interactions; Female; Humans; Methotrexate; Middle Aged; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Mast cell numbers in rheumatoid synovial tissues. Correlations with quantitative measures of lymphocytic infiltration and modulation by antiinflammatory therapy.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cell Count; Humans; Immunoenzyme Techniques; Inflammation; Injections, Intra-Articular; Knee Joint; Lymphocytes; Mast Cells; Methotrexate; Plasma Cells; Synovial Membrane | 1987 |
Comparative toxicity of total lymphoid irradiation and immunosuppressive drug treated patients with intractable rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Immune Tolerance; Immunosuppressive Agents; Infections; Lymphoid Tissue; Male; Methotrexate; Middle Aged; Radiotherapy | 1987 |
Toxicity of methotrexate in rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; HLA Antigens; Humans; Leukopenia; Male; Meningitis, Listeria; Methotrexate; Middle Aged; Pulmonary Fibrosis; Retrospective Studies; Seizures | 1987 |
Increase of dihydrofolate reductase in peripheral blood lymphocytes of rheumatoid arthritis patients treated with low-dose oral methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; DNA; Drug Resistance; Drug Tolerance; Gene Amplification; Humans; Lymphocytes; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase | 1987 |
Immunologic studies of rheumatoid arthritis patients treated with methotrexate.
Topics: Arthritis, Rheumatoid; Humans; Immunoglobulin M; Methotrexate; Monocytes; Rheumatoid Factor | 1987 |
Cryptococcosis associated with low-dose methotrexate for arthritis.
Topics: Arthritis; Arthritis, Rheumatoid; Cryptococcosis; Humans; Male; Methotrexate; Middle Aged; Opportunistic Infections; Psoriasis | 1987 |
The current status of methotrexate use in rheumatic diseases.
Topics: Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Child; Female; Humans; Methotrexate; Myositis; Pregnancy; Psoriasis | 1986 |
[Methotrexate for rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1987 |
Methotrexate in rheumatoid arthritis. Health and Public Policy Committee, American College of Physicians.
Topics: Administration, Oral; Arthritis, Rheumatoid; Humans; Injections, Intramuscular; Methotrexate | 1987 |
Low-dose methotrexate therapy for cutaneous vasculitis of rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Humans; Male; Methotrexate; Skin; Skin Diseases; Vasculitis | 1987 |
Hepatotoxicity associated with low-dose, long-term methotrexate treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Time Factors | 1987 |
[New findings in the treatment of rheumatoid arthritis using methotrexate].
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1987 |
Pulse methotrexate therapy in rheumatoid arthritis. A controlled prospective roentgenographic study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Arthrography; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies | 1987 |
[Methotrexate: from sword to ploughshare?].
Topics: Arthritis, Rheumatoid; Female; Humans; Methotrexate; Pregnancy; Pregnancy, Ectopic; Psoriasis | 1987 |
[Acute bone marrow suppression with low-dosage methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Bone Marrow; Female; Half-Life; Humans; Leukopenia; Methotrexate; Pancytopenia; Psoriasis; Thrombocytopenia | 1987 |
Hepatotoxicity after long-term methotrexate therapy.
Topics: Administration, Oral; Arthritis, Rheumatoid; Ascites; Aspartate Aminotransferases; Biopsy, Needle; Humans; Liver Cirrhosis; Methotrexate; Psoriasis; Retrospective Studies; Serum Albumin; Time Factors | 1986 |
Impact of specific therapy upon rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Drug Therapy; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Office Visits; Outcome and Process Assessment, Health Care; Penicillamine; Prospective Studies | 1986 |
Low-dose weekly oral methotrexate therapy for inflammatory arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Mixed Connective Tissue Disease; Prospective Studies; Psoriasis | 1986 |
Measures of immunologic and inflammatory responses in vitro in rheumatoid patients treated with methotrexate.
Topics: Antibody Formation; Arthritis, Rheumatoid; DNA Replication; Esterases; Humans; Immunity, Cellular; Inflammation; Methotrexate; Monocytes | 1986 |
Thymoma associated with rheumatoid arthritis in a patient taking methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Methotrexate; Thymoma; Thymus Neoplasms | 1986 |
The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Drug Administration Schedule; Female; HLA Antigens; Humans; Liver; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Radiography; Time Factors | 1986 |
Methotrexate therapy in rheumatoid arthritis. Current status.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Kinetics; Lung Diseases; Methotrexate | 1986 |
Oral methotrexate therapy for chronic rheumatoid arthritis ulcerations.
Topics: Aged; Arthritis, Rheumatoid; Bacterial Infections; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Prednisone; Sex Factors; Skin Ulcer; Vasculitis | 1986 |
FDA Arthritis Advisory Committee meeting: methotrexate; guidelines for the clinical evaluation of antiinflammatory drugs; DMSO in scleroderma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Humans; Methotrexate; Scleroderma, Systemic | 1986 |
The effect of low dose chronic intermittent parental methotrexate on delayed type hypersensitivity and acute inflammation in a mouse model.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Hypersensitivity, Delayed; Immunosuppression Therapy; Inflammation; Methotrexate; Mice; Mice, Inbred BALB C; Time Factors | 1986 |
Comparison of methotrexate with azathioprine or 6-mercaptopurine in refractory rheumatoid arthritis: a life-table analysis.
Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged | 1986 |
Low dose methotrexate pneumonitis in rheumatoid arthritis.
Topics: Aged; Alveolitis, Extrinsic Allergic; Arthritis, Rheumatoid; Female; Humans; Methotrexate | 1986 |
Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged | 1987 |
Methotrexate and rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1985 |
Methotrexate: a perspective on its use for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Leukocytes; Methotrexate | 1985 |
Methotrexate and the liver.
Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Necrosis; Serum Albumin; Transaminases | 1985 |
Pancytopenia associated with low dose pulse methotrexate in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone Marrow; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pancytopenia; Risk | 1985 |
Slow acting anti-rheumatic drugs in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aurothioglucose; Azathioprine; Cyclophosphamide; Gold; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Methotrexate; Penicillamine | 1985 |
Rheumatoid arthritis associated with expanded populations of granular lymphocytes.
Topics: Aged; Antibody-Dependent Cell Cytotoxicity; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Cyclophosphamide; Female; Humans; Killer Cells, Natural; Lymphocytes; Lymphocytosis; Male; Methotrexate; Middle Aged; Neutropenia; Phenotype; Prednisone; Rheumatoid Factor | 1986 |
Pneumonitis during low-dose methotrexate therapy.
Topics: Arthritis, Rheumatoid; Aspirin; Drug Interactions; Humans; Methotrexate; Pneumonia | 1986 |
Low incidence of hepatotoxicity associated with long-term, low-dose oral methotrexate in treatment of refractory psoriasis, psoriatic arthritis, and rheumatoid arthritis. An acceptable risk/benefit ratio.
Topics: Adult; Aged; Alcohol Drinking; Arthritis; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis | 1985 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppressive Agents; Leukemia; Lymphoma; Methotrexate; Neoplasms; Risk; Time Factors; Urinary Bladder Neoplasms | 1985 |
Methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1985 |
Hepatotoxicity of prolonged methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Methotrexate; Middle Aged; Sjogren's Syndrome | 1985 |
Low-dose methotrexate treatment of rheumatoid arthritis. Long-term observations.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Transaminases | 1985 |
Methotrexate treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Methotrexate | 1985 |
Pneumonitis complicating low-dose methotrexate therapy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Methylprednisolone; Middle Aged; Pulmonary Fibrosis | 1985 |
C-reactive protein levels in patients with rheumatoid arthritis: the impact of therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Female; Gold; Humans; Male; Methotrexate; Middle Aged; Penicillamine; Prednisone | 1985 |
[DNA-synthesizing lymphocytes in the blood of patients with disseminated lupus erythematosus, rheumatoid arthritis, and panarteritis nodosa (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chloroquine; DNA; Female; Gold; Humans; Indomethacin; Leukocyte Count; Lupus Erythematosus, Systemic; Lymphocytes; Male; Methotrexate; Methylprednisolone; Middle Aged; Penicillamine; Polyarteritis Nodosa | 1973 |
When to use cytotoxic drugs in rheumatoid arthritis.
Topics: Antigen-Antibody Complex; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Informed Consent; Male; Mercaptopurine; Methotrexate; Nitrogen Mustard Compounds; Rheumatoid Factor; Synovial Membrane; Thiotepa | 1973 |
Acute bone marrow suppression following one day oral administration of methotrexate.
Topics: Administration, Oral; Arthritis, Rheumatoid; Bone Marrow; Depression, Chemical; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Methotrexate; Middle Aged | 1974 |
[Long-term treatment with imuran and methotrexate in rheumatoid conditions].
Topics: Arthritis, Rheumatoid; Azathioprine; Dermatomyositis; Humans; Methotrexate; Polyarteritis Nodosa; Time Factors | 1972 |
Some aspects of anti-inflammatory action of immunosuppressive drugs.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Azathioprine; Carrageenan; Connective Tissue; Connective Tissue Cells; Cyclophosphamide; Edema; Female; Hydrocortisone; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Mycobacterium; Rats; Time Factors | 1974 |
Immunosuppression in the treatment of rheumatoid arthritis. Basic principles and available substances.
Topics: Alkylating Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Erythrocytes; Humans; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Mitosis; Nitrogen Mustard Compounds | 1974 |
Immunosuppressive drugs and acute leukemia.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Leukemia, Myeloid; Male; Methotrexate; Prednisone; Time Factors; Vascular Diseases | 1973 |
[Treatment with the immunosuppressive agents methotrexate and chlorambucil of patients with progessive chronic polyarthritis].
Topics: Arthritis, Rheumatoid; Chlorambucil; Chronic Disease; Female; Humans; Male; Methotrexate | 1972 |
The clinical use of immunosuppressive drugs.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Infections; Male; Methotrexate; Pregnancy; Psoriasis | 1973 |
Immunosuppressive therapy.
Topics: Anemia, Hemolytic, Autoimmune; Antigen-Antibody Reactions; Arthritis, Rheumatoid; Azathioprine; Crohn Disease; Cyclophosphamide; Female; Glomerulonephritis; Glucocorticoids; Hepatitis; Humans; Immunity; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Nephrotic Syndrome; Purpura, Thrombocytopenic | 1973 |
[Treatment of polyarthritis by immunosuppressive agents].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Evaluation Studies as Topic; Humans; Immunosuppressive Agents; Methotrexate | 1973 |
[Treatment of rheumatoid arthritis with cytostatics].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Male; Methotrexate; Middle Aged | 1974 |
[Clinical picture of rheumatologic diseases. Current status of cytostatic therapy].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppression Therapy; Methotrexate; Neoplasms; Penicillamine; Time Factors; Triaziquone | 1974 |
[Contribution on the therapy of progressive chronic polyarthritis with antimetabolites and cytostatics].
Topics: Adolescent; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Betamethasone; Chronic Disease; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Synovitis; Thiotepa | 1967 |
[Treatment of chronic connective tissue diseases with cytostatics].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Collagen Diseases; Cyclophosphamide; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisolone; Spondylitis, Ankylosing; Thiotepa; Triaziquone | 1970 |
[Preliminary studies on immunosuppressive therapy of connective tissue disorders].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Cyclophosphamide; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Methotrexate; Nephrotic Syndrome; Psoriasis | 1970 |
[The Reiter-Fiessinger-Leroy syndrome. Several autochthonous cases].
Topics: Adrenal Cortex Hormones; Adult; Arthritis, Reactive; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Male; Methotrexate; Middle Aged; Phenylbutazone; Tetracycline | 1972 |
[Immunosuppressive therapy in rheumatoid arthritis].
Topics: Administration, Oral; Adult; Aged; Anemia; Arthritis, Rheumatoid; Blood Cell Count; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Injections, Intravenous; Latex Fixation Tests; Male; Methotrexate; Middle Aged; Time Factors; Triaziquone | 1971 |
[Comparison of various immunosuppressive agents in the treatment of rheumatoid polyarthritis. 41 personal cases].
Topics: Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; Chlorambucil; Cyclophosphamide; Humans; Immunoelectrophoresis; Immunosuppressive Agents; Lymphocyte Activation; Mercaptopurine; Methotrexate; Rheumatoid Factor; Skin Manifestations; Statistics as Topic | 1971 |
[Experiences with antimetabolite therapy of malignant forms of progressive chronic polyarthritis].
Topics: Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Feeding and Eating Disorders; Humans; Mercaptopurine; Methotrexate; Nausea; Time Factors | 1966 |
[Immunosuppressive agents in the therapy of rheumatism].
Topics: Arthritis, Rheumatoid; Chlorambucil; Humans; Immunosuppressive Agents; Methotrexate; Penicillamine | 1969 |
[Cytostatic and antimetabolite therapy in chronic inflammatory joint diseases and collagen diseases].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Biopsy; Collagen Diseases; Cyclophosphamide; Humans; Immunosuppressive Agents; Injections, Intravenous; Methotrexate; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Synovial Membrane; Triaziquone | 1969 |
[Comparative study of the effect of the antimetabolic agent methotrexate in psoriasis, psoriatic arthropathy and rheumatoid arthritis].
Topics: Administration, Oral; Arthritis; Arthritis, Rheumatoid; Biopsy; Humans; Injections, Intravenous; Methotrexate; Psoriasis; Skin | 1969 |
[Collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Collagen Diseases; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Thioguanine | 1970 |
Amethopterin (methotrexate) in connective tissue disease-psoriasis and polyarthritis.
Topics: Arthritis; Arthritis, Rheumatoid; Humans; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Mouth Diseases; Psoriasis; Ulcer | 1968 |
Cytotoxic therapy in rheumatoid arthritis.
Topics: Antibody Formation; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Immunity; Mechlorethamine; Methotrexate | 1968 |
[Arthropathic pustulent psoriasis. Result of treatment with methotrexate].
Topics: Arthritis, Rheumatoid; Humans; Male; Methotrexate; Middle Aged; Psoriasis | 1968 |