Page last updated: 2024-08-25

methotrexate and Osteonecrosis

methotrexate has been researched along with Osteonecrosis in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's2 (10.00)18.2507
2000's4 (20.00)29.6817
2010's9 (45.00)24.3611
2020's3 (15.00)2.80

Authors

AuthorsStudies
Folić, M; Janković, S; Jovanović, M; Milosavljević, M; Veličković, S; Zdravković, D; Živić, M1
Amano, K; Iida, S; Kogo, M; Sugauchi, A; Yamada, C1
Abrahamsson, J; Andrés-Jensen, L; Frandsen, TL; Grell, K; Griškevičius, L; Harila-Saari, A; Joelsson, J; Jónsson, ÓG; Mogensen, SS; Nersting, J; Nielsen, SN; Niinimäki, R; Overgaard, UM; Quist-Paulsen, P; Rank, CU; Schmiegelow, K; Toft, N; Toksvang, LN; Vaitkevičienė, G1
Furudate, K; Kobayashi, W; Narita, N; Satake, A1
Carey, B; Henien, M; Hullah, E; Patel, V; Sproat, C1
Furukawa, S; Hayashida, JN; Kawano, S; Kiyoshima, T; Matsubara, R; Moriyama, M; Nakamura, S; Ogata, KI; Oobu, K; Sako, S1
Amin, N; Feltbower, R; James, B; Kinsey, S; Kraft, J; Velangi, M; Whitehead, E1
Horie, N; Kaneko, T; Kawano, R; Shimoyama, T1
Abrahamsson, J; Asberg, A; Birgens, H; Frandsen, T; Griškevičius, L; Hallböök, H; Helt, LR; Heyman, M; Jónsson, ÓG; Klausen, TW; Palk, K; Pruunsild, K; Quist-Paulsen, P; Schmiegelow, K; Toft, N; Vaitkeviciene, G; Vettenranta, K1
Blonquist, TM; Cole, PD; Finkelstein, Y; Neuberg, DS; Sallan, SE; Silverman, LB; Stevenson, KE; Vijayanathan, V; Vrooman, LM1
Hamada, T; Hara, T; Jingushi, S; Kamo, Y; Maekawa, M; Miyanishi, K; Moro-oka, TA; Torisu, T; Tsurusaki, S1
Bertorello, N; Corrias, A; Fagioli, F; Galletto, C; Manicone, R; Mussa, A; Nicolosi, MG; Porta, F1
Devidas, M; Gaynon, PS; Hunger, SP; Mattano, LA; Nachman, JB; Sather, HN; Seibel, NL; Steinherz, PG1
Dienes, HP; Kruis, W; Lanyi, B1
Hui, L; Wiernik, PH1
Bacchini, P; Bacci, G; Bertoni, F; Campanacci, L; Campanacci, M; Donati, D; Ferrari, S; Forni, C; Longhi, A; Picci, P1
Fletcher, BD; Harrison, PL; Kaste, SC; Kennedy, W; Neel, MD; Pui, CH; Razzouk, BI; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sandlund, JT1
Hartmann, D; Obrecht, JP; Obrist, R1
Babbitt, DP; Boedecker, RA; Sty, JR1
Buskila, D; Keystone, EC; Klein, M; Thomson, GT1

Reviews

3 review(s) available for methotrexate and Osteonecrosis

ArticleYear
Possible association of methotrexate use with osteonecrosis of the jaw: Systematic review.
    Journal of stomatology, oral and maxillofacial surgery, 2022, Volume: 123, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Diphosphonates; Female; Humans; Male; Methotrexate; Osteonecrosis

2022
Methotrexate-Related Lymphoproliferative Disorder in Patients With Osteonecrosis of the Jaw: A 3-Case Report and Literature Review.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2018, Volume: 76, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Biopsy; Debridement; Female; Humans; Immunohistochemistry; Lymphoproliferative Disorders; Male; Mandibular Diseases; Maxillary Diseases; Methotrexate; Osteonecrosis; Risk Factors

2018
Oral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review.
    Internal medicine (Tokyo, Japan), 2018, Feb-15, Volume: 57, Issue:4

    Topics: Aged, 80 and over; Antirheumatic Agents; Female; Humans; Jaw; Lymphoproliferative Disorders; Methotrexate; Osteonecrosis; Severity of Illness Index

2018

Trials

3 trial(s) available for methotrexate and Osteonecrosis

ArticleYear
Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
    Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; DNA Adducts; Erythrocytes; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Middle Aged; Osteonecrosis; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Thioguanine; Young Adult

2021
A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Asparaginase; Child; Child, Preschool; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Osteonecrosis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase

2017
Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Incidence; Infant; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sex Distribution; Sex Factors; Survival Rate; Treatment Outcome; Vincristine; Young Adult

2012

Other Studies

14 other study(ies) available for methotrexate and Osteonecrosis

ArticleYear
Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate.
    Acta medica Okayama, 2023, Volume: 77, Issue:1

    Topics: Arthritis, Rheumatoid; Diphosphonates; Humans; Methotrexate; Osteonecrosis; Osteoporosis

2023
Methotrexate-associated osteonecrosis of the jaw: A report of two cases.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2017, Volume: 124, Issue:6

    Topics: Aged; Antirheumatic Agents; Cone-Beam Computed Tomography; Female; Humans; Male; Mandibular Diseases; Methotrexate; Middle Aged; Osteonecrosis; Radiography, Panoramic; Tomography, X-Ray Computed; Tooth Extraction; Tooth Mobility

2017
British OsteoNEcrosis Study (BONES) protocol: a prospective cohort study to examine the natural history of osteonecrosis in older children, teenagers and young adults with acute lymphoblastic leukaemia and lymphoblastic lymphoma.
    BMJ open, 2019, 05-22, Volume: 9, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cohort Studies; Dexamethasone; Female; Glucocorticoids; Humans; Lower Extremity; Magnetic Resonance Imaging; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; United Kingdom; Vincristine; Young Adult

2019
Methotrexate-related lymphoproliferative disorder arising in the gingiva of a patient with rheumatoid arthritis.
    Australian dental journal, 2015, Volume: 60, Issue:3

    Topics: Arthritis, Rheumatoid; Epstein-Barr Virus Infections; Gingival Neoplasms; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Oral Ulcer; Osteonecrosis

2015
Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia.
    European journal of haematology, 2016, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Middle Aged; Osteonecrosis; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Thrombosis; Treatment Outcome; Vincristine

2016
Co-occurrence of subchondral insufficiency fracture of the femoral head and contralateral femoral neck fracture in a rheumatic patient receiving steroid treatment.
    Modern rheumatology, 2008, Volume: 18, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Therapy, Combination; Female; Femoral Neck Fractures; Femur Head; Fractures, Stress; Hip Fractures; Hip Joint; Humans; Magnetic Resonance Imaging; Methotrexate; Osteonecrosis; Osteoporosis, Postmenopausal; Prednisolone

2008
Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment.
    Bone, 2010, Volume: 46, Issue:4

    Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Density; Chi-Square Distribution; Child; Child, Preschool; Cyclophosphamide; Cytosine; Female; Fractures, Bone; Humans; Male; Mercaptopurine; Methotrexate; Osteonecrosis; Osteoporosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Time Factors; Ultrasonography; Vincristine

2010
[Recurrent aseptic osteonecrosis in Crohn's disease - extraintestinal manifestation or steroid related complication?].
    Deutsche medizinische Wochenschrift (1946), 2005, Aug-26, Volume: 130, Issue:34-35

    Topics: Anti-Inflammatory Agents; Arthroplasty, Replacement, Hip; Biopsy; Bone and Bones; Bone Density; Crohn Disease; Dose-Response Relationship, Drug; Female; Femur Head Necrosis; Follow-Up Studies; Hip; Humans; Long-Term Care; Methotrexate; Middle Aged; Muscle Weakness; Osteonecrosis; Prednisone; Recurrence

2005
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD).
    American journal of hematology, 1996, Volume: 52, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1996
Histologic response of high-grade nonmetastatic osteosarcoma of the extremity to chemotherapy,.
    Clinical orthopaedics and related research, 2001, Issue:386

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Logistic Models; Male; Methotrexate; Multivariate Analysis; Osteonecrosis; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Treatment Outcome

2001
Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.
    Leukemia, 2001, Volume: 15, Issue:6

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Arthralgia; Arthroplasty, Replacement, Hip; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Femur Head Necrosis; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; Vincristine

2001
Osteonecrosis after chemotherapy.
    Lancet (London, England), 1978, Jun-17, Volume: 1, Issue:8077

    Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Humerus; Methotrexate; Middle Aged; Osteonecrosis

1978
Bone scintigraphy: Methotrexate associated bone necrosis.
    Wisconsin medical journal, 1979, Volume: 78, Issue:10

    Topics: Child, Preschool; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteonecrosis; Radionuclide Imaging

1979
Avascular necrosis of bone mimicking symmetric polyarthritis in a patient with malignant lymphoma treated with high-dose steroids.
    Israel journal of medical sciences, 1992, Volume: 28, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Bleomycin; Cyclophosphamide; Diagnosis, Differential; Doxorubicin; Female; Humans; Lymphoma, Large-Cell, Immunoblastic; Methotrexate; Osteonecrosis; Prednisolone; Prednisone; Vincristine

1992