methotrexate has been researched along with Osteogenic Sarcoma in 916 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 372 (40.61) | 18.7374 |
| 1990's | 174 (19.00) | 18.2507 |
| 2000's | 149 (16.27) | 29.6817 |
| 2010's | 176 (19.21) | 24.3611 |
| 2020's | 45 (4.91) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X; Deng, Y; Li, Y; Li, Z; Wei, D; Xiang, F; Xu, Y | 1 |
| Bajpai, J; Banavali, SD; Khan, SA; Kumar, VS; Mailankody, S | 1 |
| Aoki, Y; Bouvet, M; Hamada, K; Han, Q; Hoffman, RM; Kubota, Y; Masaki, N; Nishida, K; Tome, Y; Yamamoto, J | 1 |
| Abe, K; Furukawa, T; Hashimoto, H; Ishizu, T; Iwata, S; Kawano, Y; Kobayashi, E; Maeda-Minami, A; Mano, Y; Miyazaki, S; Shimoi, T; Yamaguchi, M | 1 |
| De Pinieux, G; Le Nail, LR; Narciso, B; Salaün, H; Simon, C; Vegas, H; Vinceneux, A | 1 |
| Alcasabas, AP; Blair, S; Dhamne, C; Lam, C; Leung, KWP; Loh, AHP; Monsereenusorn, C; Oh, BLZ; Photia, A; Puhaindran, ME; Rodriguez-Galindo, C; Rujkijyanont, P; Soh, SY; Traivaree, C; Veerapan, P; Wang, E | 1 |
| Alemi, F; Farsad-Akhtar, N; Malakoti, F; Maleki, M; Mohammadi, E; Yousefi, B | 1 |
| Majidinia, M; Malakoti, F; Sanapour, N; Shanebandi, D; Soleimanpour, J; Targhazeh, N; Yousefi, B | 1 |
| Cheng, H; Ran, S; Shao, C; Sun, W; Wan, Y; Yin, X; Zhang, M; Zhu, Z | 1 |
| Elhasid, R; Levin, D; Manisterski, M; Peled, Y; Shiran, S; Shukrun, R | 1 |
| Chekhonin, VP; Li, H; Li, S; Li, Z; Lin, Y; Ma, W; Peltzer, K; Wang, J; Wang, X; Wu, H; Xu, G; Xu, Y; Xue, Y; Zhang, C; Zhang, J | 1 |
| Khyavi, PA; Shanehbandi, D; Soleimanpour, J; Valizadeh, A; Yousefi, B | 1 |
| Bielack, SS; Blattmann, C; Borkhardt, A; Csóka, M; Hassenpflug, W; Hecker-Nolting, S; Kabíčková, E; Kager, L; Kessler, T; Kevric, M; Kratz, C; Kühne, T; Lehrnbecher, T; Mayer-Steinacker, R; Mettmann, V; Metzler, M; Reichardt, P; Rossig, C; Sorg, B; von Luettichau, I; Windhager, R | 1 |
| Gomes, CMF; Martins-Neves, SR; Sampaio-Ribeiro, G | 1 |
| Hills, F; Low, K; Roberts, HC; Stordal, B | 1 |
| An, HY; Bai, B; Sun, MX; Sun, YB | 1 |
| Cohen, IJ; Sadeh, M; Toledano, H | 1 |
| Fu, D | 1 |
| Hashida, N; Isshiki, K; Sakai, M; Sato, S; Shima, H; Shimada, H; Takimoto, T | 1 |
| Chen, G; Ji, C; Li, J; Li, M; Long, Z; Lu, Y; Wang, Q; Wang, Z; Xiang, L; Yu, H | 1 |
| Chang, YL; Chen, WM; Chou, YC; Huang, KW; Hung, GY; Lee, HC; Wang, SF; Wu, PK | 1 |
| Mehrvar, A; Mehrvar, N; Sadeghi, Y; Tashvighi, M | 1 |
| Ishizaki, J; Kitagawa, K; Nakano, C; Sai, Y; Suga, Y | 1 |
| Bernhardt, MB; Cheng, WS; Foster, JH; Rainusso, N; Wang, LL; Young, EP | 1 |
| Li, J; Li, R; Lu, X; Zhang, B; Zhang, Y | 1 |
| Jayakrishnan, A; Kumar, TSS; Prasad, SR | 2 |
| Fujiwara, T; Jeys, LM; Parry, MC; Stevenson, JD; Sumathi, V; Tsoi, K; Tsuda, Y | 1 |
| Li, X; Liu, Y; Shen, J; Xu, R; Yu, X; Zhang, X | 1 |
| Aguado, L; Gutiérrez, M; Idoate, MÁ; Moreno-Artero, E; Querol-Cisneros, E; Rodríguez-Garijo, N; Tomás-Velázquez, A | 1 |
| Alemi, F; Asemi, Z; Bazavar, M; Fazli, J; Ma, B; Maleki, M; Mohammadi, E; Valizadeh, A; Xing, S; Yousefi, B | 1 |
| Bao, Q; Cheng, J; Han, J; Hu, Y; Liu, X; Song, R; Wang, W; Wang, Z; Wu, S; Yao, Y; Yu, L; Yu, W; Yu, X; Yu, Y; Zhang, G; Zhang, W; Zhao, M | 1 |
| Fried, M; Krämer, I; Kühn, M; Rosentreter, J | 1 |
| Doval, DC; Jain, S; Kapoor, G; Sharma, P; Tripathi, R; Verma, P | 1 |
| Duan, W; Ji, L; Wei, W; Zhu, J | 1 |
| Anderson, PM; Gennatas, S; Gulia, A; Huang, PH; Jones, RL; Smrke, A | 1 |
| Abe, K; Araki, Y; Asano, Y; Hayashi, K; Higuchi, T; Igarashi, K; Ikeda, H; Miwa, S; Morinaga, S; Nojima, T; Takeuchi, A; Taniguchi, Y; Tsuchiya, H; Yamamoto, N; Yonezawa, H | 1 |
| Cao, S; Hao, Y; Peng, C; Ren, Z; Zhang, P; Zhu, J | 1 |
| Alemi, F; Asemi, Z; Golchin, A; Javadi, S; Khiavi, PA; Maleki, M; Soleinmapour, J; Younesi, S; Yousefi, B | 1 |
| Xiang, RM; Yan, JP | 1 |
| Demir, B; Demir, E; Sütcüoğlu, O; Ünsal, O; Yazıcı, O | 1 |
| Hiraga, H; Ozaki, T | 1 |
| Chen, F; Chen, J; Gong, Y; Li, X; Luo, L; Ma, Y; Shi, C; Sun, Y; Wang, L; Xu, Z | 1 |
| Guruprasad, CS; Nair, M; Prasanth, VR; Rajeswari, B; Sugath, BS; Thankamony, P | 1 |
| Le, T; Shahriyari, L; Su, S | 1 |
| Arana, S; Blanco-Prieto, MJ; Errazquin-Irigoyen, M; González-Fernández, Y; Hisey, CL; Imbuluzqueta, E; Mitxelena-Iribarren, O; Mujika, M | 1 |
| Gehrs, BC; Meyer, WH; Palacios, MF; Pokala, HR; Pratap, S | 1 |
| Li, S; Xiong, Y; Zhang, X | 1 |
| Holt, GE; Lipshultz, ER; Lipshultz, SE; Ramasamy, R; Yechieli, R | 1 |
| Dhooge, C; Labarque, V; Laenen, A; Lambrecht, L; Renard, M; Sinnaeve, F; Sleurs, C; Uyttebroeck, A | 1 |
| da Motta Girardi, D; da Silva Rocha, LS; Feher, O; Negrão, MV | 1 |
| Bahrami, A; Billups, CA; Daryani, VM; Daw, NC; Kunkel, M; Loeb, DM; Mao, S; McCarville, MB; Navid, F; Neel, M; Pappo, AS; Rao, BN; Reikes Willert, J; Santana, VM; Shulkin, BL; Smith, W; Stewart, CF; Ward, D; Wu, J | 1 |
| Meshkini, A; Oveisi, H | 1 |
| Deng, ZP; Ding, Y; Jin, T; Li, B; Liu, BY; Niu, XH; Sun, Y | 1 |
| Bajpai, J; Banavali, SD; Chandrakanth, MV; Chandrasekharan, A; Ghosh, J; Gupta, S; Khan, A; Khurana, S; Rekhi, B; Simha, V; Talreja, V; Vora, T | 1 |
| Gupta, A; Hopyan, S; Koo, A; Renzi, S; Taylor, T; Tsimerman, E | 1 |
| Avan, A; de Sá Lopes, AC; Dos Santos Cavalcanti, A; Gholamin, S; Hanae Kasai Brunswick, T; Kahn, SA; Leite Duarte, ME; Matheus Guimarães, JA; Meohas, W; Razavi, M; Ribeiro, GO | 1 |
| Cacciavillano, W; Rose, A; Scopinaro, M; Villegas Rubio, JA; Zubizarreta, P | 1 |
| Fang, GW; Liu, W; Xue, Y; Zhang, YJ; Zhao, X | 1 |
| Han, Z; Shi, L | 1 |
| Bompas, E; Bouvier, C; Brisse, HJ; Brugieres, L; Castex, MP; Cheurfa, N; Corradini, N; Delaye, J; Entz-Werlé, N; Gaspar, N; Gentet, JC; Italiano, A; Le Deley, MC; Lervat, C; Marec-Berard, P; Mascard, E; Occean, BV; Pacquement, H; Piperno-Neumann, S; Redini, F; Saumet, L; Schmitt, C; Tabone, MD; Verite-Goulard, C | 1 |
| Altaf, S; Broomall, E; Cooper, J; Hogan, MC; Khan, S; Rodriguez, V; Scott, K; Wyatt, KD | 1 |
| Bagatell, R; Balamuth, N; Balis, F; Fox, E; Levin, K; Segers, B; Womer, R; Zhu, Y | 1 |
| Collier, CD; Getty, PJ; Greenfield, EM; Knafler, GJ; Morris, WZ; Wirtz, EC | 1 |
| Bai, J; Cui, Y; Ding, L; Han, X; Li, R; Wang, C; Zhou, Y | 1 |
| Nath, A; Sims, E; Sugalski, A | 1 |
| Bernardino, PN; Bersano, PRO; Lima Neto, JF; Sforcin, JM | 1 |
| Bouazza, N; Brugieres, L; Corradini, N; Entz-Werle, N; Fresneau, B; Freycon, C; Gaspar, N; Gentet, JC; Laurence, V; Le Deley, MC; Le Teuff, G; Lervat, C; Lui, G; Mahier Ait Oukhatar, C; Marec Berard, P; Millot, F; Pacquement, H; Piperno-Neumann, S; Schneider, P; Taque, S; Treluyer, JM | 1 |
| Kawai, A; Kobayashi, H; Ogura, K; Shinoda, Y; Tanaka, S; Tsuda, Y | 1 |
| Berber, M; Dincaslan, H; Incesoy Ozdemir, S; Tacyildiz, N; Unal, E; Yavuz, G | 1 |
| Grant, R; Gupta, AA; Hendershot, E; Mills, D; Nicksy, D; Ramachandran, N; Riss, V; Shaikh, F; Taylor, T; Volpe, J | 1 |
| Barceló, B; Berga, F; Costa-Bauza, A; Elorza, MÁ; Gimenez, S; Gomila, I; Grases, F; Luna, P; Martorell, C; Rey, J; Sánchez, I | 1 |
| Bajpai, J; Banavali, S; Chandrasekharan, A; Ghosh, J; Gupta, S; Karpe, A; Pandey, N; Rekhi, B; Simha, V; Singh, A; Talreja, V; Vora, T | 1 |
| Li, Z; Xu, R; Xu, W; Xu, Y; Zhu, X | 1 |
| Cheng, WTF; Chu, HM; Fong, PS; Hui, KH; Lam, TN | 1 |
| Bubalo, J; Dang, T; Davis, LE; Fu, R; Gundle, KR; Paxton, J; Ryan, CW; Stork, L; Wippel, B | 1 |
| Anninga, J; Antal, I; Arndt, C; Bernstein, M; Bielack, SS; Brown, KLB; Butterfass-Bahloul, T; Calaminus, G; Capra, M; Dhooge, C; Eriksson, M; Flanagan, AM; Friedel, G; Gebhardt, MC; Gelderblom, H; Goldsby, R; Gorlick, R; Grier, HE; Grimer, R; Hawkins, DS; Hecker-Nolting, S; Hogendoorn, P; Ingleby, FC; Isakoff, MS; Janeway, KA; Jovic, G; Kabickova, E; Kager, L; Krailo, MD; Kühne, T; Lang, S; Lau, CC; Leavey, PJ; Lessnick, SL; Marina, N; Mascarenhas, L; Mayer-Steinacker, R; Meyers, PA; Nagarajan, R; Randall, RL; Rechnitzer, C; Reichardt, P; Renard, M; Schwartz, CL; Smeland, S; Strauss, S; Sundby Hall, K; Sydes, MR; Teot, L; Timmermann, B; von Kalle, T; Whelan, J | 1 |
| Bao, S; Chan, ACL; Chan, JKC; Lau, GTC; Yau, DTW; Zheng, Z | 1 |
| Gao, HD; Hou, ZL; Tang, QX; Wang, LC; Wang, Y | 1 |
| Chen, P; Li, S; Pei, Y; Qiu, E; Wang, W; Zhang, X; Zheng, K | 1 |
| He, A; Hu, H; Lin, F; Min, D; Shen, Z; Tang, L; Yu, W; Zheng, S | 1 |
| Abboud, MR; Abou Ali, B; Akel, S; Boulos, F; El-Solh, H; Ghanem, KM; Haidar, R; Muwakkit, SA; Saab, R; Saghieh, S; Salman, M; Tamim, H | 1 |
| Feng, A; Han, C; Liu, R; Lv, Y; Mao, Y; Tian, Y; Xu, D; Yu, D; Zhang, S; Zhao, Y; Zhu, Q | 1 |
| de Haan, J; Oude Munnink, T; Touw, D; van der Meer, A; van Kruchten, M | 1 |
| Anract, P; Bertucci, F; Blay, JY; Bompas, E; Brugieres, L; Collard, O; Cupissol, D; de Pinieux, G; Delaye, J; Duffaud, F; Italiano, A; Laurence, V; Le Cesne, A; Le Deley, MC; Occean, BV; Penel, N; Perrin, C; Piperno-Neumann, S; Ray-Coquard, I; Rios, M | 1 |
| Aoki, Y; Araki, N; Hashimoto, N; Ieguchi, M; Kudawara, I; Kuratsu, S; Matsumine, A; Mori, S; Myoui, A; Naka, N; Nakanishi, H; Ueda, T; Yoshikawa, H | 1 |
| Asadi, N; Bini, A; Caroli, G; Dell'Amore, A; Dolci, G; Stella, F | 1 |
| Bi, W; Han, G; Jia, J; Wang, W; Xu, M | 1 |
| Arush, MW; Ash, S; Bonda-Shkedi, E; Cohen, IJ; Goshen, Y; Kaplinsky, C; Yaniv, I | 1 |
| Charoenkwan, P; Choeyprasert, W; Natesirinilkul, R; Sittipreechacharn, S | 1 |
| Byun, BH; Cho, WH; Choi, CW; Jeon, DG; Koh, JS; Kong, CB; Lee, SY; Lim, I; Lim, SM; Song, WS | 1 |
| Hou, WG; Liu, Y; Ma, C; Sun, XH; Zhao, HX; Zhao, YL | 1 |
| Asprodini, E; Begas, E; Daliani, D; Papandreou, C; Papatsibas, G; Tsakalof, A | 1 |
| Golovko, TS; Gulak, LO; Kobys, VL; Konovalenko, VF; Matyushok, OF; Repinа, NV; Tarasova, TO; Zaharycheva, EV | 1 |
| Bai, SB; Bao, YX; Chen, HX; Luo, X; Zhong, JJ | 1 |
| Bienemann, K; Hanenberg, H; Howe, SJ; Kramm, CM; Sena-Esteves, M; Staege, MS | 1 |
| Crews, KR; Navid, F; Panetta, JC; Scott, JR; Ward, DA | 1 |
| Cai, HQ; Li, YC; Wang, ZG; Xu, YL; Yang, J | 1 |
| Chauhan, N; Christensen, R; Daugherty, C; Howard, SC; Jayaprakash, N; King, TR; Pui, CH; Rush, JE; Schwartz, S; Widemann, BC | 1 |
| Li, JM; Li, X; Li, YG; Si, M; Tian, JG; Zhao, J | 1 |
| Boye, K; Del Prever, AB; Eriksson, M; Fagioli, F; Ferrari, S; Hall, KS; Lindholm, P; Saeter, G; Skjeldal, S; Tienghi, A | 1 |
| Bain, E; Birhiray, RE; Reeves, DJ | 1 |
| Bisogno, G; Marzollo, A | 1 |
| Bruneau, B; Chappé, C; Gandemer, V; Robert, G; Taque, S | 1 |
| Bar-Sela, G; Miller, RC; Novotny, PJ; Sio, TT; Sohawon, S; Thariat, J; Van Houtte, P; Vu, CC | 1 |
| Li, B; Li, H; Li, Y; Sun, L; Ye, Z; Zhang, J | 1 |
| Diller, L; Duffey-Lind, E; Ebb, D; Grier, H; Kenney, LB; Sklar, CA | 1 |
| Bickels, J; Flusser, G; Gortzak, Y; Issakov, J; Kolander, Y; Kushnir, I; Merimsky, O | 1 |
| Fukuoka, N; Houchi, H; Kosaka, S; Motoki, T; Takeuchi, T; Tanaka, H; Watanabe, M; Yamaguchi, K | 1 |
| Jaffe, N | 9 |
| Ellis, D; Necessary, CA; Roffwarg, D | 1 |
| Chen, H; Chen, P; Duan, Z; He, W; Wang, H; Wang, J; Zou, JX | 1 |
| Pei, FX; Song, YC; Yang, XN; Zeng, JC; Zhang, H | 1 |
| Dolžan, V; Goričar, K; Jazbec, J; Kovač, V; Lamovec, J; Zakotnik, B | 1 |
| Fu, WM; Hsieh, IS; Yang, RS | 1 |
| Chang, WH; Chen, PC; Chen, WM; Chiou, HJ; Hsu, HE; Hung, GY; Wu, HT; Yen, CC; Yen, HJ | 1 |
| Duarte, IF; Gil, AM; Lamego, I; Marques, MP | 1 |
| Xu, M; Xu, S; Yu, X | 1 |
| Wang, W; Wang, Z; Xiao, X | 1 |
| Jiang, S; Lin, N; Liu, Y; Wang, Y; Xu, Y; Ye, Z | 1 |
| Anninga, J; Bernstein, M; Bielack, SS; Böhling, T; Butterfass-Bahloul, T; Calaminus, G; Capra, M; Deffenbaugh, C; Dhooge, C; Eriksson, M; Flanagan, AM; Gelderblom, H; Goorin, A; Gorlick, R; Gosheger, G; Grimer, RJ; Hall, KS; Helmke, K; Hogendoorn, PC; Hook, JM; Jovic, G; Jundt, G; Kager, L; Krailo, M; Kuehne, T; Lau, CC; Letson, GD; Marina, N; Meyer, J; Meyers, PA; Morris, C; Mottl, H; Nadel, H; Nagarajan, R; Randall, RL; Schomberg, P; Schwarz, R; Smeland, S; Sydes, MR; Teot, LA; Whelan, JS | 1 |
| Lao, L; Li, Q; Song, C; Zhang, W | 1 |
| Lin, F; Shen, Z; Tang, L; Yao, Y; Yu, W | 1 |
| Anurathapan, U; Choeyprasert, W; Chuansumrit, A; Hongeng, S; Nartthanarung, A; Pakakasama, S; Sirachainan, N; Songdej, D | 1 |
| Lu, W; Niu, X; Tian, X; Zhang, Q; Zhang, W; Zhao, H; Zhen, J | 1 |
| Mills, DK; Sun, L | 1 |
| Benini, S; Ferrari, S; Gambarotti, M; Hattinger, CM; Magagnoli, G; Michelacci, F; Palmerini, E; Picci, P; Sella, F; Serra, M | 1 |
| Cheng, C; Crews, KR; Jeha, S; Molinelli, AR; Navid, F; Relling, MV; Scott, JR; Stewart, CF; Swanson, HD; Ward, DA; Zhou, Y | 1 |
| Kyr, M; Neradil, J; Pavlasova, G; Sramek, M; Sterba, J; Veselska, R | 1 |
| Alnæs, GI; Andersen, AM; Hall, KS; Holmboe, L; Jabeen, S; Kristensen, VN | 1 |
| Wang, YP; Yang, ZP | 1 |
| Baumhoer, D; Bernstein, M; Bielack, SS; Böhling, T; Brennan, B; Butterfass-Bahloul, T; Calaminus, G; Deffenbaugh, C; Dhooge, C; Eriksson, M; Gebhardt, M; Gelderblom, H; Gerss, J; Goorin, A; Gorlick, R; Helmke, K; Hogendoorn, PC; Hoogerbrugge, PM; Hook, JM; Jovic, G; Jürgens, H; Kager, L; Krailo, MD; Kühne, T; Lau, CC; Letson, GD; Marina, N; Meyer, J; Meyers, P; Michelagnoli, M; Morris, C; Nadel, H; Nagarajan, R; Pápai, Z; Picton, S; Randall, RL; Reichardt, P; Renard, M; Schomberg, P; Seddon, B; Smeland, S; Sundby Hall, K; Sydes, MR; Teot, LA; Tunn, PU; van den Berg, H; Werner, M; Whelan, JS; Windhager, R | 1 |
| Duan, H; Gong, RR; Xiong, Y; Yang, XR | 1 |
| Ash, S; Cohen, IJ; Issakov, J; Kollender, Y; Shkalim-Zemer, V; Toledano, H; Yaniv, I | 1 |
| Bakhshi, S; Batra, A; Khan, SA; Nataraj, V; Rastogi, S; Sharma, MC; Vishnubhatla, S | 1 |
| Bernstein, ML; Devidas, M; Gebhardt, MC; Goorin, AM; Grier, HE; Healey, JH; Krailo, MD; Lipshultz, SE; Meyers, PA; Sato, JK; Schwartz, CL; Steinherz, LJ; Teot, LA; Wexler, LH | 1 |
| Fujiwara, M; Fujiwara, T; Kawai, A; Numoto, K; Ogura, K; Suzuki, S; Yonemoto, T; Yoshida, A | 1 |
| Chintagumpala, M; Helman, L; Hicks, MJ; Jo, E; Krance, R; Lau, C; Meyer, W; Murray, J; Venkatramani, R | 1 |
| Ferrari, S; Serra, M | 1 |
| Chen, X; Cheng, Y; He, C; Liu, J; Ma, H; Yang, Z; Zang, J | 1 |
| Bishop, MW; Brinkman, TM; Cheung, YT; Daryani, VM; Edelmann, MN; Hudson, MM; Kimberg, C; Krull, KR; Liu, W; Mulrooney, DA; Ness, KK; Robison, LL; Srivastava, DK; Stewart, CF | 1 |
| Effinger, KE; Link, MP | 1 |
| Ding, M; Huang, J; Jin, Q; Liu, K; Ni, J; Song, D; Wang, J | 1 |
| Bernstein, ML; DuBois, SG; Gorlick, RG; Janeway, KA; Krailo, MD; Marina, N; Morris, CD; Randall, RL; Teot, LA; Villaluna, D | 1 |
| Abdul-Rahman, O; Bai, P; Dér, Á; Fodor, T; Kiss, B; Nagy, L; Szántó, M | 1 |
| Gan, ZH; Han, K; Hu, HY; Li, KP; Lin, SC; Liu, Y; Lu, ZG; Min, DL; Tseng, KF; Zhao, RH; Zhou, Y | 1 |
| Dinçaslan, H; Ensari, A; Kiremitçi, S; Özçakar, ZB; Taktak, A; Yalçınkaya, F; Yılmaz, S | 1 |
| Fellenberg, J; Fischer, C; Kunz, P; Lehner, B; Sähr, H; Seebach, E | 1 |
| Djerada, Z; Feliu, C; Gozalo, C; Marquet, B; Millart, H; Oudart, JB | 1 |
| Bi, WZ; Han, G; Huang, JQ; Jia, JP; Mao, BB; Wang, DY; Wang, W; Wu, YN; Xu, M | 1 |
| Biason, P; Fanelli, M; Ferrari, S; Gagno, S; Giodini, L; Hattinger, CM; Iacoboni, E; Picci, P; Roli, A; Roncato, R; Scotlandi, K; Serra, M; Tavanti, E; Toffoli, G; Vella, S | 1 |
| Antal, P; Arany, A; Csoka, M; Csordas, K; Eipel, O; Erdelyi, DJ; Gezsi, A; Hegyi, M; Kovacs, GT; Kutszegi, N; Muller, J; Semsei, AF; Szalai, C | 1 |
| Deng, P; Junger, WG; Qi, B; Sun, D; Wang, C; Wang, T; Xia, Y; Yao, J; Yu, T; Zhang, X | 1 |
| Fanelli, M; Hattinger, CM; Picci, P; Serra, M; Tavanti, E; Vella, S | 1 |
| Niu, XH; Zhang, Q; Zhang, W; Zhen, JC; Zheng, TT | 1 |
| Fujiki, M; Kawai, A; Miyamoto, S; Setsu, N | 1 |
| Azuma, E; Hirayama, M; Imai, H; Iwamoto, S; Komada, Y; Matsumine, A; Miura, Y; Nakatani, K; Toyoda, H; Yodoya, N | 1 |
| Chakraborty, J; Ray, S; Sa, B; Saha, S | 1 |
| Park, JA; Shin, HY | 1 |
| Bagarry-Liegey, D; Ciccolini, J; Deville, JL; Duffaud, F; Dupuis, C; Durand, A; Fanciullino, R; Favre, R; Iliadis, A; Mercier, C; Monjanel-Mouterde, S; Pourroy, B; Yang, C | 1 |
| Bielack, SS; Ferrari, S; Helman, LJ; Marina, N; Reaman, GH; Smeland, S; Whelan, JS | 1 |
| Arndt, CA; Hawkins, DS; Hoots, WK; Inwards, CY; Kleinerman, ES; Koshkina, NV; Morales-Arias, JA; Munsell, MF; Rodriguez, NI | 1 |
| Gorlick, R; Jaffe, N | 1 |
| Bouchireb, K; Brugières, L; Dodille, A; Dubrel, M; Gouraud, F; Ponvert, C | 1 |
| Goldwasser, F; Mir, O; Ropert, S | 1 |
| Cendros, JM; Colom, H; Domenech, J; Farré, R; Mangues, MA; Pardo, N; Peraire, C; Soy, D; Torrent, M | 1 |
| Castellani, GC; Fanelli, M; Hattinger, CM; Michelacci, F; Pasello, M; Picci, P; Remondini, D; Scionti, I; Scotlandi, K; Serra, M; Stoico, G | 1 |
| Bjornard, K; Jayabose, S; Kudlowitz, D; Nowicki, TS; Sandoval, C | 1 |
| Marrodán, L; Patiño-García, A; San-Julián, M; Sierrasesúmaga, L; Zalacaín, M | 1 |
| de Camargo, B; van Dalen, EC | 1 |
| Boldrini, R; Cozza, R; De Ioris, MA; Devito, R; Donfrancesco, A; Fidani, P; Zama, M | 1 |
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| Deutsch, EC; Lynch, DR; Perlman, SL; Seyer, LA; Yu, J | 1 |
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| Akbulut, H; Demirkazik, A; Dincol, D; Dogan, M; Icli, F; Karabulut, HG; Tukun, A; Utkan, G; Yalcin, B | 1 |
| Friesenbichler, J; Leithner, A; Obermayer-Pietsch, B; Pirker-Frühauf, UM; Urban, EC | 1 |
| Fallarini, S; Lombardi, G; Orsi Battaglini, N; Paoletti, T | 1 |
| Chen, J; Cheng, X; Jiang, X; Shi, X; Wu, S; Zhang, J; Zhao, J; Zhou, G | 1 |
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| Choy, E; Duan, Z; Hornicek, FJ; Liu, X; Mankin, H; Yang, W | 1 |
| Bao, CF; Li, XH; Yang, LM | 1 |
| Alberghini, M; Fabbri, N; Ferrari, C; Ferrari, S; Palmerini, E; Picci, P; Staals, E | 1 |
| Lagrange, F; Molimard, M; Moore, N; Péhourcq, F; Titier, K | 1 |
| Cole, PD; Kamen, BA; Smith, AK | 1 |
| Arbus, GS; Bash, RO; Hansch, E; Leavey, PJ; Quigley, R; Saland, JM | 1 |
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| Davis, KA; Walker, JC; Williams, P | 1 |
| Bacci, G; Benini, S; Bertoni, F; Briccoli, A; Ferrari, S; Incaprera, M; Manara, MC; Mercuri, M; Picci, P; Reverter-Branchat, G; Scotlandi, K; Serra, M | 1 |
| Bordin, JO; Cecyn, KZ; Lee, J; Oguro, T; Petrilli, AS | 1 |
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| Bacchini, P; Bacci, G; Bertoni, F; Briccoli, A; Donati, D; Ferrari, S; Forni, C; Galletti, S; Giacomini, S; Longhi, A; Manfrini, M; Rocca, M | 1 |
| Chang, TT; Chang, WH; Chen, RL; Hsiao, TC; Hung, IJ; Lin, DT; Lin, KH; Lin, KS; Lin, MT; Lu, MY; Shu, SG; Wu, CT; Yang, CP; Yang, RS | 1 |
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| BERTINO, JR; HELLMAN, S; IANNOTTI, AT | 1 |
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| Benini, S; Castellani, GC; Hattinger, CM; Manara, MC; Pasello, M; Picci, P; Remondini, D; Reverter-Branchat, G; Scotlandi, K; Serra, M | 1 |
| Assaraf, YG; Ifergan, I; Issakov, J; Meller, I | 1 |
| Bacci, G; Briccoli, A; De Paolis, M; Ferrari, S; Forni, C; Longhi, A; Ruggieri, P; Setola, E | 1 |
| Benini, S; Chano, T; Hattinger, CM; Manara, MC; Maurici, D; Pasello, M; Picci, P; Reverter-Branchat, G; Scotlandi, K; Serra, M; Shen, JN | 1 |
| Aldaz, A; Aquerreta, I; Giráldez, J; Sierrasesúmaga, L | 1 |
| Colvin, M; Duan, X; Jia, SF; Kleinerman, ES; Lafleur, EA; Zhou, Z | 1 |
| Arush, MW; Assaraf, YG; Cole, PD; Drori, S; Elhasid, R; Ifergan, I; Jansen, G; Kamen, BA; Kaspers, GJ; Kaufman, Y; Matherly, LH; Rechavi, G; Sahar, D; Sirota, J; Toren, A | 1 |
| Choy, JH; Han, OJ; Jeong, J; Jung, JS; Kang, YK; Oh, JM; Park, M | 1 |
| Blayac, JP; Cociglio, M; Hillaire-Buys, D; Margueritte, G; Peyriere, H; Vallat, C | 1 |
| Crews, KR; Daw, NC; Link, MP; Liu, T; Meyer, WH; Panetta, JC; Rodriguez-Galindo, C; Tan, M | 1 |
| Adamson, PC; Bacci, G; Balis, FM; Bielack, S; Craft, AW; Ferrari, S; Kempf-Bielack, B; Pratt, CB; Widemann, BC | 1 |
| Itoi, E; Nagasawa, H; Okada, K; Sakamoto, H; Shimada, Y; Takahashi, S | 1 |
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| Berta, M; Bertoni, F; del Prever, AB; Fagioli, F; Ferrari, S; Mercuri, M | 1 |
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| Bacci, G; Bertoni, F; Ferrari, C; Longhi, A; Pasini, E; Pignotti, E | 1 |
| Gorlick, R; Healey, J; Huvos, AG; Kellick, M; Lo, S; Meyers, PA; Sankaran, M; Shi, W; Wexler, LH; Zelcer, S | 1 |
| Antonescu, CR; Berens, ME; Brown, KM; Chen, W; Daluski, A; Gorlick, R; Healey, JH; Henry, MM; Hilmer, SC; Huvos, AG; Lafleur, B; Macdonald, TJ; Mazza, B; McDonough, WS; Meyers, PA; Mintz, MB; Ramsey, KE; Sowers, R; Stephan, DA | 1 |
| Bernstein, ML; Betcher, D; Conrad, E; Ferguson, W; Gebhardt, M; Goorin, AM; Grier, H; Harris, MB; Healey, J; Huvos, A; Kleinerman, ES; Krailo, M; Link, M; Meyers, PA; Montebello, J; Nadel, H; Nieder, M; Sato, J; Schwartz, CL; Siegal, G; Weiner, M; Wells, R; Wold, L; Womer, R | 1 |
| Mekni, A; Mrad, K; Oubiche, F; Romdhane, KB; Sassi, S; Smida, M | 1 |
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| Bacci, G; Cesari, M; Ferrari, S; Lamanna, G; Pieretti, F; Tolentinis, L; Verri, E; Versari, M; Zolezzi, C | 1 |
| Boglione, A; Cattel, L; Comandone, A; Ferrari, S; Passera, R; Tagini, V | 1 |
| Angulo, F; Hardwicke, FL; Nugent, KM; Perez-Verdia, A | 1 |
| Chintagumpala, M; Davino, N; Helman, L; Hicks, J; Johnson, M; Lau, CC; Man, TK; Meyer, W; Murray, J; Perlaky, L; Shen, J; Triche, T; Visvanathan, J; Wong, KK | 1 |
| Brodsky, I; Rosenbluth, JZ; Styler, MJ; Zak, D | 1 |
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| Alvegard, TA; Bacci, G; Bernini, G; Bertoni, F; Böhling, T; Brosjö, O; Capanna, R; Comandone, A; Del Prever, AB; Ferrari, S; Longhi, A; Mercuri, M; Müller, C; Picci, P; Ruggieri, P; Saeter, G; Smeland, S; Tienghi, A; Wiebe, T | 1 |
| Goi, K; Hamada, Y; Inukai, T; Nakazawa, S; Sato, H; Sugita, K; Tezuka, T; Uno, K | 1 |
| Arndt, CA; Doherty, DK; Gordon, N; Hawkins, DS; Inwards, CY; Kleinerman, ES; Koshkina, NV; Munsell, MF; Stewart, J | 1 |
| Berger, M; Berta, L; Fagioli, F; Ferrero, I; Frairia, R; Madon, E; Palmero, A; Rustichelli, D; Venturi, C | 1 |
| Billups, CA; Cain, AM; Daw, NC; Jenkins, JJ; McCarville, MB; Meyer, WH; Neel, MD; Rao, BN; Rodriguez-Galindo, C | 1 |
| Alleva, R; Benassi, MS; Borghi, B; Gellert, N; Neuzil, J; Pazzaglia, L; Picci, P; Tomasetti, M | 1 |
| Hioki, Y; Kusuzaki, K; Matsumine, A; Seto, M; Sonoda, J; Tomoda, R; Uchida, A | 1 |
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| Bacchini, P; Bacci, G; Bertoni, F; Longhi, A; Loro, L; Picci, P; Serra, M; Versari, M | 1 |
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| Bacci, G; Balladelli, A; Barbieri, E; Briccoli, A; Fabbri, N; Ferrari, S; Forni, C; Longhi, A; Mercuri, M; Picci, P | 1 |
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| Chau, PY; Co, NN; Kwok, TT; Tsang, TY; Tsang, WP; Wong, RP | 1 |
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| Bacci, G; Balladelli, A; Bertoni, F; Briccoli, A; Ferrari, S; Forni, C; Longhi, A; Mercuri, M; Picci, P; Serra, M | 1 |
| Bacci, G; Bertoni, F; Ferrari, S; Palmerini, E | 1 |
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| Anderson, P; Chang, EL; Herzog, CE; Hughes, D; Huh, W; Kornguth, DG; Mahajan, A; Pelloski, CE; Woo, SY | 1 |
| Bernstein, ML; Betcher, D; Ferguson, WS; Gebhardt, MC; Goorin, AM; Grier, HE; Harris, M; Healey, JH; Kleinerman, E; Krailo, MD; Link, MP; Meyers, PA; Nadel, H; Nieder, M; Schwartz, CL; Siegal, GP; Weiner, MA; Wells, RJ; Womer, RB | 1 |
| Gorlick, R; Kellick, M; Meyers, PA; Wexler, LH; Zelcer, S | 1 |
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| Breithaupt, H; Fischer, HP; Pralle, H; Schulz, A | 1 |
| Baum, E; Bleyer, WA; Fryer, C; Griffin, T; Lampkin, B; Lukens, J; Morgan, E; Movassaghi, N; Provisor, A; White, H | 1 |
| Caceres, E; de la Flor, J; Misad, O; Tejada, F; Valdivia, S; Zaharia, M; Zubrod, G | 1 |
| Kummet, TD | 1 |
| Cserhati, MD; Groscurth, P; Hofmann, V; Honegger, HP; von Hochstetter, A | 1 |
| Hunyadi, K; Nagy, K; Velkey, L | 1 |
| Engel, A; Kotz, R; Kumpan, W; Lechner, G; Salzer-Kuntschik, M; Sekera, J | 1 |
| Chia, KB; Chua, EJ; Khor, TH; Tan, BC | 1 |
| Kofránek, I; Kraus, P; Matĕjovský, Z; Trnka, V | 1 |
| Endoh, F; Hodaka, E; Ishii, T; Takada, N; Umeda, T | 1 |
| Abelson, HT; Frei, E; Jaffe, N; Smith, E | 1 |
| Fritsch, G; Urban, C | 1 |
| Baldwin, RW; Embleton, MJ; Garnett, MC; Jacobs, E | 1 |
| Chan, KW; Duncan, CP; Knowling, MA; Morton, KS | 1 |
| Ogihara, Y; Sekiguchi, K; Tsuruta, T | 1 |
| Drake, S; Nelson, JA | 1 |
| Baldwin, RW; Embleton, MJ; Garnett, MC; Pimm, MV; Rowland, GF; Simmonds, RG | 1 |
| Burny, F; Klastersky, J; Lejeune, FJ; Otten, J | 1 |
| Rytwiński, K | 1 |
| Breithaupt, H; Küenzlen, E | 2 |
| Belasco, JB; Grossman, RI; Packer, RJ | 1 |
| Cacavio, A; Caparros, BI; Groshen, S; Huvos, AG; Lane, JM; Marcove, RC; Nirenberg, A; Rosen, G | 1 |
| Ayala, A; Bowman, R; Cangir, A; Chuang, V; Jaffe, N; Knapp, J; Prudich, J; Wallace, S; Wang, YM | 1 |
| Andräs, A; Bachmann, R; Ebell, W; Göbel, U; Jürgens, H; Kupke, I; Richter, O | 1 |
| Allen, J; Juergens, H; Mehta, B; Rosen, G | 1 |
| Lange, B; Levine, AS | 1 |
| Korinthenberg, R; Lütkenhöner, B; Palm, D; Ritter, J | 1 |
| Bacci, G; Campanacci, M; Giunti, A; Pagani, P | 1 |
| Ghanta, VK; Hiramoto, RN | 1 |
| da Costa, M; Iqbal, MP; Isacoff, W; Rothenberg, SP | 1 |
| Eilber, FR; Grant, TT; Mirra, JJ; Morton, DL; Weisenburger, T | 1 |
| Gutjahr, P; Pontz, BF | 1 |
| Chacón, RD; Filmus, J; Mordoh, J | 1 |
| Boden, JA; Kaye, SB; Ryman, BE | 1 |
| Kotz, R; Mutz, ID; Seewann, H; Urban, C | 1 |
| Rathbun, SB; Rose-Williamson, K | 1 |
| Eilber, FR | 1 |
| Jentsch, E; Poppe, H; Prindull, G; Schauer, A | 1 |
| Abelson, HT; Beardsley, GP; Fellows, KE; Frei, E; Goorin, A; Jaffe, N; Link, M; Vawter, G; Watts, H | 1 |
| Mulder, JH; Smink, T; van Putten, LM | 1 |
| Fudenberg, HH; Hynes, JB; Tsang, KY | 1 |
| Arai, S; Azuma, E; Hirai, S; Hirota, H; Inoue, M; Kamiya, H; Kato, M; Kawabe, Y; Kawai, K; Kazuoka, K; Komada, Y; Matsuda, T; Nakabayashi, T; Nakano, C; Nobori, T; Nomura, T; Ogiwara, T; Sakurai, M; Shibata, T; Shimizu, S; Uejima, A | 1 |
| Goto, M; Ishii, S; Isu, K; Nakasato, T; Sasaki, T; Ubayama, Y; Usui, M; Yagi, T; Yamawaki, S | 1 |
| Hosoya, R; Howell, SK; Sutow, WW; Wang, YM | 1 |
| Bowles, D; Evans, WE; Green, AA; Howarth, C; Kumar, AP; Pratt, CB; Ransom, JL; Rivera, G | 1 |
| Neerhout, RC; Renholds, DC; Ridgway, D; Wolff, LJ | 1 |
| Biran, S; Katz, E; Levi, M; Rizel, S; Sulkes, A | 1 |
| Bowles, D; Coburn, T; Evans, W; Pratt, C; Price, RA | 1 |
| Göbel, U; Jürgens, H; Rosen, G; von Voss, H; Wahn, V | 1 |
| Gehan, EA; Sutow, WW | 1 |
| Decker, DA; Edmonson, JH; Gilchrist, GS; Kovach, JS; Offord, JR; Taylor, WF | 1 |
| Bigot, P; Bouffet, E; Brunat-Mentigny, M; Philip, T; Pouyau, G | 1 |
| Abelson, HT; Beardsley, GP; Cohen, D; Frei, E; Jaffe, N; Link, MP; Traggis, D; Watts, H | 1 |
| Huvos, AG; Juergens, H; Kosloff, C; Mehta, BM; Nirenberg, A; Rosen, G | 1 |
| Abelson, HT; Frei, E; Goorin, AM | 2 |
| Cortes, EP; Holland, JF | 1 |
| Pratt, CB | 1 |
| Goto, M | 1 |
| Bernstein, ID; Bleyer, WA; Chard, RL; Feigl, P; Greenlee, TK; Haas, JE; Hartmann, JR; Johnson, FL; Morgan, A; Pendergrass, TW; Schaller, RT | 1 |
| Caparros, B; Caravelli, JF; Heelan, RT; Huvos, AG; Rosen, G; Smith, J; Urmacher, C | 1 |
| Nakamura, T | 1 |
| Evans, AE; Gregg, JR; Kramer, S; Lange, B; Toledano, S; Wimmer, R | 1 |
| Bertolone, SJ; Clark, LW; Hilton, MA; Kmetz, DR; Patel, CC | 1 |
| Nirenberg, A; Rosen, G | 1 |
| Rosen, G; Urban, C | 1 |
| Lowe, J; Makin, M; Sulkes, A | 1 |
| Am, YB; Brenner, HJ; Tichler, TE | 1 |
| Amino, K | 1 |
| Cantwell, BM; Fennelly, JJ; Jones, MP | 1 |
| Diehl, V; Engelhardt, P; Oellerich, M; Schaadt, M | 1 |
| Cregan, ET; Dahlin, DC; Edmonson, JH; Gilchrist, GS; Green, SJ; Ivins, JC; Pritchard, DJ; Smithson, WA; Taylor, WF | 1 |
| Franchimont, C; Pierard, GE | 1 |
| DeVita, VT; Henney, JE; Weiss, RB | 1 |
| Chiari, K; Endler, T; Gabl, F; Kotz, R; Krisch, K; Leber, H; Salzer-Kuntschik, M | 1 |
| Cortes, EP; Glidewell, O; Holland, JF | 1 |
| Rosenberg, SA | 1 |
| Dennebaum, R; Fischer, J; Preiss, J; Przybylski, M | 1 |
| Abe, M | 1 |
| Diehl, V | 1 |
| Almasan, A; Banerjee, D; Bertino, JR; Fan, J; Hochhauser, D; Kelly, R; Li, W; Wahl, GM; Yin, Y; Zielinski, Z | 1 |
| Benjamin, RS; Jaffe, N; Patel, SR | 1 |
| Carpentier, AF; Chantelard, JV; Henin, D; Poisson, M | 1 |
| Ho, KC; Ho, SK; Johnson, PJ; Kumta, SM; Leung, WT; Lin, J; Metreweli, C | 1 |
| Bramwell, V; Mertens, WC | 1 |
| Link, MP | 2 |
| Bielack, SS; Delling, G; Jürgens, H; Kotz, R; Salzer-Kuntschik, M; Winkler, K | 1 |
| Krailo, M; Miser, JS | 1 |
| Avella, M; Bacci, G; Casadei, R; Cazzola, A; Ferrari, S; Lari, S; Monti, C; Picci, P; Prever, BA; Ruggieri, P | 1 |
| Heller, G; Meyers, PA; Vlamis, V | 1 |
| Delepine, G; Delepine, N; Desbois, JC | 2 |
| Contesso, G; Edeline, V; Kalifa, C; Lemerle, J; Razafindrakoto, H; Valteau, D; Vanel, D; Vassal, G | 1 |
| Ekert, H; Tiedemann, K | 1 |
| Göeken, LN; Kamps, WA; Molenaar, WM; Postma, A; Schraffordt Koops, H; Veth, RP | 1 |
| George, M; Goorin, A; Letvak, LA; Link, M; Poplack, D; Strother, D | 1 |
| Kabuto, M; Kitai, R; Kobayashi, H; Kodera, T; Kubota, T; Nakagawa, T; Nozaki, J; Sato, K | 1 |
| Hsi, SN; Kiu, MC; Lai, GM; Liaw, CC; Lu, CS; Yang, TS | 1 |
| He, Q; Li, HG; Ma, ZT | 1 |
| Kalifa, C; Lemerle, J; Raquin, M; Rodary, C; Tabone, MD; Valteau-Couanet, D | 1 |
| al-Lamki, Z; el-Banna, N; Jaffe, N; Thomas, E | 1 |
| Betlemovic, M; Bode, U; Fuchs, N; Graf, N; Winkler, K | 1 |
| Bacci, G; Fabbri, A; Ferrari, S; Figus, E; Longhi, C; Marchesini, G; Marchi, E; Motta, E | 1 |
| Burgers, JM | 1 |
| Higaki, S; Takeyama, S; Tateishi, A; Yamanashi, M | 1 |
| Astier, A; Brun, B; Goutallier, D; Hernigou, P; le Bourgeois, JP | 1 |
| Burgers, JM; Craft, AW | 1 |
| Bauer, HC; Brosjö, O; Kreicbergs, A; Lindholm, J; Nilsonne, U; Silfverswärd, C; Strander, H; Szamosi, A | 1 |
| Elomaa, I | 1 |
| Arndt, CA; Edmonson, JH; Gilchrist, GS; Miser, JS; Pritchard, DJ; Rock, MG; Schaid, DJ; Shives, TC; Smithson, WA | 1 |
| Ayass, M; Cassano, W; Dickson, N; Enneking, W; Graham-Pole, J; Heare, M; Heare, T; Marcus, R; Saleh, R; Spanier, S | 1 |
| Advani, SH; Dinshaw, KA; Pande, SC; Suraiya, JN; Susnerwala, SS | 1 |
| Rosen, G | 4 |
| Fukaya, N; Katagiri, H; Nakanishi, K; Sato, K; Sugiura, H; Takahashi, M; Yamamura, S | 1 |
| Chauveinc, L; Follezou, JY; Guerin, JM | 1 |
| Cui, TH | 1 |
| Fujinami, S; Nakaseko, K; Ogihara, Y | 1 |
| Bacci, G; Brach Del Prever, A; Casadei, R; Ferrari, S; Mancini, A; Picci, P; Tienghi, A | 1 |
| Bacci, G; Brach del Prever, A; Casadei, R; Ferrari, S; Gherlinzoni, F; Mercuri, M; Monti, C; Picci, P; Ruggieri, P; Tienghi, A | 1 |
| Borsi, J; Kálmánchey, R; Koós, R; Majtényi, K | 1 |
| Carlson, RW; Catolico, M; Reid, T; Yuen, A | 1 |
| Borsi, JD; Koós, R; Kovács, GT; Paál, C; Schuler, D; Somló, P | 1 |
| Andoh, J; Beaumel, A; Hilaire, A; Konata, I; Kouie, JP; M'Bengue, TA; Quattara, DN; Toutoukpo, Y | 1 |
| Nakano, M; Norimatsu, H; Oka, S; Tsukamoto, T; Yoshioka, S | 1 |
| Barrett, G; George, M; Jaffe, N; Jorgensen, K; Letvak, L; Robertson, R | 1 |
| Catalin, J; Duffaud, F; Durand, A; Favre, R; Guillet, P; Lacarelle, B; Monjanel, S; Pignon, T | 1 |
| Liu, JQ; Wu, DW | 1 |
| Cho, KJ; Jang, JJ; Jeon, DG; Kim, SS; Lee, SY | 1 |
| Avidor, I; Cohen, IJ; Goshen, Y; Kaplinsky, C; Katz, K; Mor, C; Yaniv, Y; Yosipovitch, Z; Zaizov, R | 1 |
| Kotz, R; Mader, RM; Proprentner, R; Rainer, H; Rizovski, B; Steger, GG | 1 |
| Avella, M; Figus, E; Gnudi, S; Ripamonti, C | 1 |
| Bacci, G; Battistini, A; Ferrari, S; Orlandi, M; Puggioli, C; Sassoli, V; Strazzari, S | 1 |
| Couthon, HM; Hosain, F; Spencer, RP; Sturtz, GL | 1 |
| Al-Lamki, Z; Jaffe, N; Pearson, P | 1 |
| Bessis, D; Guilhou, JJ; Hellier, I; Margueritte, G; Sotto, A | 1 |
| Adamson, PC; Balis, FM; Hetherington, ML; Murphy, RF; Widemann, BC | 1 |
| Alkins, SA; Byrd, JC; Morgan, SK; Ward, FT; Weiss, RB | 1 |
| Butenko, AK; Glukhovskaia, IIu; Konovalenko, VF; Tolstopiatov, BA | 1 |
| Goorin, A; Hallowell, JA; Kharasch, VS; Lipsitz, S; Santis, W | 1 |
| Marcove, RC | 2 |
| Dembowska-Bagińska, B; Jurczyk-Procyk, S; Kozera, M; Perek, D; Piekarczyk, A; Prokopczyk, J; Wieckowska, J; Witkowska-Ozogowska, J; Zelazowski, J | 1 |
| Aoki, M; Hino, M; Honoki, K; Kido, A; Mii, Y; Miura, S; Miyauchi, Y; Morishita, T; Nakanishi, E; Nomura, Y; Tamai, S | 1 |
| Amaya, J; Aymerich, ML; Calvo, M; Maldonado, S; Muñoz Villa, A; Ocete, G; Otheo, E | 1 |
| Bacci, G; Bertoni, F; Comandone, A; Ferrari, S; Ferraro, A; Mercuri, M; Picci, P; Ruggieri, P; Tella, G | 1 |
| Bacci, G; Delepine, G; Delepine, N; Desbois, JC; Rosen, G | 1 |
| Barisone, E; Brach Del Prever, A; Leone, L; Miniero, R; Ridolfi, L; Vivalda, M; Vivenza, C | 1 |
| Fujimoto, T | 1 |
| Bacci, G; Cazzola, A; Ferrari, S; Gherlinzoni, F; Iantorno, D; Picci, P; Zolezzi, C | 1 |
| Baum, ES; Betcher, DL; Ettinger, LJ; Huvos, AG; Kisker, CT; Krailo, MD; Makley, JT; Miser, JS; Nachman, JB; Provisor, AJ; Yunis, EJ | 1 |
| Bacci, G; Bertoni, F; Briccoli, A; Donati, D; Ferrari, S; Forni, C; Manfrini, M; Mercuri, M; Monti, C; Zanoni, A | 1 |
| Araki, N; Myoui, A; Shinto, Y; Uchida, A; Ueda, T; Yoshikawa, H | 1 |
| Connolly, LP; Ecklund, K; Goorin, AM; Jaramillo, D; Laor, T | 1 |
| al Mahr, M; Hughes, DO; Lee, DB; Leung, S; Marshall, GM; Tobias, V | 1 |
| Alvegård, TA; Björk, O; Elomaa, I; Saeter, G; Solheim, OP; Strander, H; Wiebe, T | 1 |
| Hamada, M; Inoue, H; Kawai, A; Kunisada, T; Sugihara, S | 1 |
| Alexandre, J; Brain, E; Minozzi, C; Misset, JL | 1 |
| Clifton-Bligh, P; Jackson, C; Laurent, MR; Mason, RS; Preston, SJ | 1 |
| Hayakawa, M; Ishii, S; Kawaguchi, S; Murakami, M; Uede, T | 1 |
| Bertino, JR; Fan, J; Hochhauser, D; Li, WW | 1 |
| Beron, G; Bielack, SS; Winkler, K | 1 |
| Bacci, G; Bertoni, F; Campanacci, M; Cesari, M; Ferrari, S; Forni, C; Gasbarrini, A; Mercuri, M; Sottili, S; Tienghi, A | 1 |
| Bacci, G; Brach del Prever, A; Briccoli, A; Ferrari, S; Gasbarrini, A; Mercuri, M; Picci, P; Pinto, D; Tienghi, A | 1 |
| Andersen, A; Bruland, OS; Ekstrøm, PO; Giercksky, KE; Slørdal, L | 1 |
| Glukhovskaia, IIu | 1 |
| Bacci, G; Ferrari, S; Mercuri, M; Picci, P | 1 |
| Bacchini, P; Bacci, G; Bertoni, F; Brach del Prever, A; Campanacci, M; Comandone, A; Delepine, N; Ferrari, S; Mercuri, M; Picci, P; Tienghi, A | 1 |
| Bruland, OS; Pihl, A | 1 |
| Bacci, G; Bernini, G; Brach del Prever, A; Capanna, R; Cesari, M; Comandone, A; Ferrari, S; Longhi, A; Mercuri, M; Picci, P; Tienghi, A | 1 |
| Koshino, T; Saito, T; Takagi, T; Yoshida, K | 1 |
| Bertino, JR; Gorlick, R; Kellick, M; Meyers, P | 1 |
| Casper, E; Gorlick, R; Healey, JH; Heller, G; Huvos, AG; Lane, J; Meyers, PA | 1 |
| Aronson, J; Jarka, DE; Nicholas, RW | 1 |
| Brunat-Mentigny, M; Cochat, P; Dubourg, L; Hadj-Aïssa, A; Koch Nogueira, PC; Schell, M | 1 |
| Bielack, SS; Bieling, P; Delling, G; Epler, D; Fuchs, N; Graf, N; Heise, U; Jürgens, H; Körholz, D; Kotz, R; Salzer-Kuntschik, M; Weinel, P; Werner, M; Winkler, K | 1 |
| Ayala, A; Ferguson, WS; Gieser, P; Goorin, AM; Harris, MB; Holbrook, T; Link, MP; Shochat, SJ | 1 |
| Enneking, WF; Lindner, NJ; Scarborough, MT; Spanier, SS | 1 |
| Amigo-Ferreiro, ME; Bonnay, M; Grill, J; Hartmann, O; Schoepfer, C; Valteau-Couanet, D; Vassal, G | 1 |
| Bailey, CC; Gattamaneni, HR; Lashford, LS; Lewis, IJ; Michelagnoli, MP | 1 |
| Bertino, JR; Gorlick, R; Guo, W; Healey, JH; Huvos, AG; Ladanyi, M; Meyers, PA | 1 |
| Bacci, G; Cesari, M; Fasano, MC; Ferrari, S; Lamanna, G; Zolezzi, C | 1 |
| Iqbal, MP | 1 |
| Flombaum, CD; Meyers, PA | 1 |
| Hoare, D; Leonard, P; Whelan, J | 1 |
| Cohen, IJ; Katz, K; Kidron, D; Meller, I; Tomer, G; Yosipovitch, Z; Zaizov, R | 1 |
| Alvegård, TA; Brosjö, O; Engström, K; Follerås, G; Forestier, E; Holmström, T; Monge, O; Saeter, G; Stenwig, AE; Strander, H; Wahlqvist, Y; Wiebe, T; Wiklund, T; Willén, H | 1 |
| Ashihara, T; Hashiguchi, S; Hirasawa, Y; Hirata, M; Kusuzaki, K; Murata, H; Takeshita, H | 1 |
| Carter, SR; Grimer, RJ; Kabukcuoglu, Y; Mangham, DC; Spooner, D; Tillman, RM | 1 |
| Babin-Boilletot, A; Brunat-Mentigny, M; Kalifa, C; Mahmoud, HH; Pacquement, H; Schmitt, C; Tabone, MD; Terrier, P | 1 |
| Blay, JY; Brunat-Mentigny, M; Chauvin, F; Demaille, MC; Gentet, JC; Iliescu, C; Krakowski, I; Pacquement, H; Philip, T; Soler-Michel, P; Thiesse, P | 1 |
| Aparicio, J; Garcerá, S; Montalar, J; Munárriz, B; Oltra, A; Pastor, M; Santaballa, A; Segura, A; Yuste, A | 1 |
| Akamatsu, N; Hamada, Y; Seki, K; Shiiki, K; Tasaka, K; Yoshikawa, H | 1 |
| Horiuchi, R; Shinozaki, T; Takagishi, K; Tomidokoro, R; Watanabe, H; Yamamoto, K | 1 |
| Ben Abdallah, M; Ben Ayed, F; Ben Ghachem, M; Ben Hamida, H; Ben Hassine, H; Ben Romdhane, K; Boussen, H; Daldoul, O; Douik, M; Gamoudi, A; Karray, S; Khalfallah, S; Mezlini, A; Mezzi, F; Saadi, A | 1 |
| Debatin, KM; Ewerbeck, V; Fellenberg, J; Mau, H; Nedel, S | 1 |
| Boruczkowski, D; Chybicka, A; Gołebiowski, W; Jaworski, W; Katski, K; Kazanowska, B; Kowalczyk, J; Kołecki, P; Leda, M; Liebhart, M; Wecławek-Tompol, J; Woźniak, W | 1 |
| Hirata, Y; Kato, T; Kobayashi, H; Morita, T; Okada, Y; Sato, T | 1 |
| Decker, S; Nies, B; van Valen, F; Winkelmann, W | 1 |
| Hanioka, K; Hayashi, Y; Kizaki, T; Marui, T; Minami, R; Mizuno, K; Yamamoto, T | 1 |
| Akman, S; Carroll, MI; Doroshow, JH; Leong, LA; Longmate, JA; Margolin, KA; Morgan, RJ; Newman, EM; Raschko, JW; Slatkin, N; Somlo, G; Tetef, ML | 1 |
| Ben Arush, MW; Ben-Barak, A; Elhasid, R; Levin, K; Postovsky, S | 1 |
| Aldaz, A; Aquerreta, I; Beorlegui, B; Giráldez, J; Ortega, A; Sierrasesúmega, L | 1 |
| Bacci, G; Bertoni, F; Campanacci, M; Casadei, R; Fabbri, N; Ferrari, S; Forni, C; Longhi, A; Picci, P; Ruggieri, P; Versari, M | 1 |
| Craft, AW; Lewis, IJ; Machin, D; Stark, D; Weeden, S | 1 |
| Cole, PD; Kamen, BA | 1 |
| Bacci, G; Bertoni, F; Fabbri, N; Ferrari, S; Forni, C; Longhi, A; Versari, M; Zavatta, M | 1 |
| Bacchini, P; Bacci, G; Bertoni, F; De Giorgi, U; Ferrari, S; Fiorentini, G; Forni, C; Longhi, A; Mercuri, M; Picci, P; Rimondini, S; Tienghi, A | 1 |
| Gebski, V; Machin, D; Tai, BC; White, I | 1 |
| Arbizu, J; López de Mesa, R; Narbona, J; Sánchez-Carpintero, R; Sierrasesúmaga, L | 1 |
| Goto, E; Okamoto, I; Tanaka, K; Tomojiri, S | 1 |
| Bacchini, P; Bacci, G; Bertoni, F; Campanacci, L; Campanacci, M; Donati, D; Ferrari, S; Forni, C; Longhi, A; Picci, P | 1 |
| Bacci, G; Bernini, G; Biagini, R; Briccoli, A; Capanna, R; Donati, D; Fabbri, N; Ferrari, S; Longhi, A; Versari, M | 1 |
| Abe, S; Ganev, GG; Nakano, H; Ogawa, K; Tateishi, A | 1 |
| Auvrignon, A; Dalle, JH; Kalifa, C; Leverger, G; Vassal, G | 1 |
| Berend, KR; Dibernardo, L; Harrelson, JM; Moore, JO; Pietrobon, R; Scully, SP | 1 |
| Chowbay, B; Siong, KK | 1 |
| Kim, HS; Lee, SH; Oh, JH; Park, YB; Yoo, KH | 1 |
| Hu, Y; Lei, S; Mao, Y; Pei, F; Wei, Y; Zeng, J | 1 |
| Blum, R; Seymour, JF; Toner, G | 1 |
| Takahashi, M; Yamada, K; Yoshida, M | 1 |
| Hisada, T; Ito, T; Masuda, S; Mochida, A; Morinari, H; Nakahara, K; Nishi, K; Saito, K; Sasaki, S; Tahara, M; Yakumaru, K | 1 |
| Auvrignon, A; Dalle, JH; Leverger, G; Vassal, G | 1 |
| Alvegard, TA; Bacci, G; Briccoli, A; Donati, D; Ferrari, S; Forni, C; Lari, S; Longhi, A; Manfrini, M; Mercuri, M; Picci, P; Saeter, G | 1 |
| Boruczkowski, D; Chybicka, A; Gołebiowski, W; Jaworski, W; Katski, K; Kazanowska, B; Kijowski, J; Kowalczyk, J; Kołecki, P; Leda, M; Liebhart, M; Wecławek-Tompol, J; Woźniak, W | 1 |
| Hauben, EI; Hogendoorn, PC; Pringle, J; Van Marck, EA; Weeden, S | 1 |
| Douglass, HO; Friedman, M; Mindell, E; Takita, H; Wallace, HJ; Wang, J | 1 |
| Arbes, H; Kotz, R; Leber, H; Ramach, W; Wolf, A | 1 |
| Kubanek, B; Schreml, W | 1 |
| Caparros, B; Huvos, AG; Kosloff, C; Marcove, RC; Nirenberg, A; Rosen, G | 1 |
| Bourne, RG | 1 |
| Nirenberg, A | 1 |
| Kotz, R; Leber, H; Rella, W | 1 |
| Evans, AE | 1 |
| Burchenal, JH | 2 |
| Livingston, RB | 1 |
| Sullivan, MP; Sutow, WW | 1 |
| Eveloff, AR; Lascari, AD | 1 |
| Kotz, D; Krisch, K; Mehta, BM | 1 |
| Jenkin, RD | 1 |
| Austin, EH; Drake, J; Goldberg, NH; Romolo, JL; Rosenberg, SA | 1 |
| Butler, TP; Sybert, A | 1 |
| Etcubanas, E; Giritsky, AS; Mark, JB | 1 |
| Handelsman, H; Muggia, FM | 1 |
| Janka, G | 1 |
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| Harms, D; Lasson, U; Wiedemann, HR | 1 |
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| Rietberg, M | 1 |
| Freeman, JE; Malpas, JS | 1 |
| Cassady, JR; Das, L; Djerassi, I; Farber, S; Frauenberger, G; Geiser, C; Jaffe, N; Kim, BS; Paed, D; Traggis, D | 1 |
| Beattie, EJ; Kwon, C; Murphy, ML; Rosen, G; Suwansirikul, S; Tan, C; Wu, SJ | 1 |
| Pratt, CB; Roberts, D; Shanks, EC; Warmath, EL | 1 |
| Freckman, HA | 1 |
| Carter, SK; Friedman, MA | 1 |
| Bishop, Y; Frei, E; Jaffe, N; Traggis, D | 1 |
| Amiel, JL; Cattan, A; de Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Rosenfeld, C; Schlumberger, JR; Schneider, M; Schwarzenberg, L | 1 |
| Mahaley, MS; Woodhall, B | 1 |
77 review(s) available for methotrexate and Osteogenic Sarcoma
| Article | Year |
|---|---|
Resource-appropriate selection of osteosarcoma treatment protocols in low- and middle-income countries.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Developing Countries; Humans; Methotrexate; Osteosarcoma; Young Adult | 2022 |
Chemoresistance-Related Stem Cell Signaling in Osteosarcoma and Its Plausible Contribution to Poor Therapeutic Response: A Discussion That Still Matters.
Topics: Adolescent; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Signal Transduction | 2022 |
A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.
Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Leukopenia; Methotrexate; Network Meta-Analysis; Osteosarcoma; Survival Rate; Thrombocytopenia; Treatment Outcome | 2020 |
Future Directions in the Treatment of Osteosarcoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Immunotherapy; Male; Medical Oncology; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Precision Medicine; Prognosis; Quality of Life; Treatment Outcome | 2021 |
Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Doxorubicin; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Osteosarcoma | 2021 |
Concomitant Administration of High-dose Methotrexate and Low-dose Aspirin Without Any Delay in Methotrexate Clearance in a Patient With Osteosarcoma: A Case Report and Review of the Literature.
Topics: Aspirin; Bone Neoplasms; Child; Glomerular Filtration Rate; Humans; Male; Methotrexate; Osteosarcoma | 2018 |
Efficacy of methotrexate, doxorubicin, and cisplatin for osteosarcoma: Study protocol for a systematic review of randomized controlled trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Quality of Life; Randomized Controlled Trials as Topic; Research Design | 2019 |
Methotrexate, doxorubicin, and cisplatinum regimen is still the preferred option for osteosarcoma chemotherapy: A meta-analysis and clinical observation.
Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Survival Analysis | 2019 |
Recurrent primary cardiac osteosarcoma: a case report and literature review.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Fatal Outcome; Heart Neoplasms; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Reoperation | 2014 |
Analysis of chemotherapy dosage and dosage intensity and survival outcomes of high-grade osteosarcoma patients younger than 40 years.
Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Grading; Osteosarcoma; Treatment Outcome | 2014 |
Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cohort Studies; Disorder of Sex Development, 46,XY; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Luteinizing Hormone; Male; Methotrexate; Osteosarcoma; Prognosis; Review Literature as Topic; Spermatogenesis; Testis; Testosterone; Young Adult | 2014 |
Historical perspective on the introduction and use of chemotherapy for the treatment of osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Routes; Drug Administration Schedule; History, 20th Century; History, 21st Century; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome | 2014 |
The role of chemotherapy for metastatic, relapsed and refractory osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Deoxycytidine; Docetaxel; Etoposide; Gemcitabine; Humans; Ifosfamide; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Taxoids | 2014 |
An update on chemotherapy for osteosarcoma.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic | 2015 |
Pharmacogenomics of genes involved in antifolate drug response and toxicity in osteosarcoma.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Folic Acid Antagonists; Humans; Methotrexate; Neoplasm Grading; Osteosarcoma; Pemetrexed; Pharmacogenetics; Trimetrexate | 2017 |
Methotrexate for high-grade osteosarcoma in children and young adults.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Humans; Methotrexate; Osteosarcoma; Young Adult | 2009 |
Osteosarcoma: review of the past, impact on the future. The American experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma | 2009 |
Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects.
Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Hearing Loss; Heart Diseases; Humans; Ifosfamide; Infertility; Kidney Diseases; Methotrexate; Neoplasms, Second Primary; Neurotoxicity Syndromes; Osteosarcoma; Survivors | 2010 |
Methotrexate for high-grade osteosarcoma in children and young adults.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Humans; Methotrexate; Osteosarcoma; Quality of Life; Young Adult | 2011 |
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Male; Methotrexate; Osteosarcoma | 2012 |
Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Survival Analysis | 2011 |
Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis.
Topics: Abdominal Wall; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Calcinosis; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Neoadjuvant Therapy; Organ Sparing Treatments; Osteosarcoma; Radiography; Razoxane; Receptor, IGF Type 1; Skin Neoplasms; Subcutaneous Tissue; Tibia; Time Factors; Young Adult | 2011 |
The activity of the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease-Free Survival; Doxorubicin; Extremities; Feasibility Studies; Gene Expression Profiling; Humans; Ifosfamide; Japan; Medical Oncology; Methotrexate; Multicenter Studies as Topic; Neoplasm Staging; Osteosarcoma; Perioperative Period; Practice Guidelines as Topic; Research Design; Societies, Medical; Soft Tissue Neoplasms; Survival Analysis; Treatment Outcome | 2012 |
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine | 2003 |
[Progress and stagnation in chemotherapy protocols for primary osteosarcoma].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Multicenter Studies as Topic; Neoadjuvant Therapy; Osteosarcoma; Preoperative Care; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis | 2003 |
High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Kidney; Methotrexate; Osteosarcoma; Renal Dialysis | 2004 |
Osteosarcoma occurring in osteogenesis imperfecta.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; DNA Mutational Analysis; DNA, Neoplasm; Doxorubicin; Humans; Ifosfamide; Immunohistochemistry; Lung Neoplasms; Male; Methotrexate; Osteogenesis Imperfecta; Osteosarcoma; Radiography, Thoracic; Thigh; Tomography, X-Ray Computed; Treatment Outcome; Tumor Suppressor Protein p53 | 2004 |
[Soft tissue sarcoma: postoperative chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Administration Schedule; Humans; Ifosfamide; Melphalan; Mesna; Methotrexate; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine | 2004 |
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chondrosarcoma; Combined Modality Therapy; Desmin; Diagnosis, Differential; Fatal Outcome; Female; Fibrosarcoma; Humans; Humerus; Mesenchymoma; Methotrexate; Neoplasm Proteins; Neoplasms, Multiple Primary; Osteolysis; Osteosarcoma; Postoperative Complications; Pulmonary Embolism; Radiography; Rhabdomyosarcoma; Sarcoma, Ewing | 2004 |
Combination of gemcitabine and irinotecan for recurrent metastatic osteogenic sarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Cisplatin; Combined Modality Therapy; Deoxycytidine; Doxorubicin; Etoposide; Femoral Neoplasms; Gemcitabine; Head and Neck Neoplasms; Humans; Ifosfamide; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Palliative Care; Salvage Therapy; Scalp; Skin Neoplasms; Thoracotomy | 2005 |
[Neoadjuvant treatment in osteosarcomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma | 2006 |
[Recent developments in chemotherapy of malignant diseases].
Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Female; Genetic Techniques; Hodgkin Disease; Hormones; Humans; Immunotherapy; Interferons; Male; Mechlorethamine; Methotrexate; Mitoxantrone; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Nitrosourea Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Receptors, Cell Surface; Tretinoin; Vincristine | 1982 |
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma | 1980 |
[Drug therapy of malignant tumors of the bone and soft tissues].
Topics: Adolescent; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms | 1981 |
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma | 1981 |
Chemotherapy in osteosarcoma. Basis for application and antagonism to implementation; early controversies surrounding its implementation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Disease-Free Survival; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Randomized Controlled Trials as Topic; Remission Induction; Survival Rate; Treatment Outcome | 1995 |
Osteosarcoma and other tumors of bone.
Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Disease-Free Survival; Female; Humans; Male; Methotrexate; Mutation; Osteosarcoma; Prognosis; Tomography; Tumor Suppressor Protein p53 | 1995 |
Treatment of osteosarcoma: experience of the Cooperative Osteosarcoma Study Group (COSS).
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Germany; Humans; Ifosfamide; Immunologic Factors; Interferon-beta; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic; Treatment Outcome; Vincristine | 1993 |
Osteosarcoma of the extremities: chemotherapy experience at Memorial Sloan-Kettering.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; New York; Osteosarcoma; Prognosis; Proportional Hazards Models; Racial Groups; Retrospective Studies; Risk; Survival Rate; Treatment Outcome | 1993 |
Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disarticulation; Doxorubicin; Europe; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome; Vincristine | 1993 |
The European Osteosarcoma Intergroup (E.O.I.) studies 1980-1991.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Europe; Humans; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome | 1993 |
An update of Scandinavian studies of osteosarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Scandinavian and Nordic Countries; Survival Rate; Treatment Outcome | 1993 |
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Humans; Ifosfamide; Life Tables; Male; Methotrexate; Minnesota; Necrosis; Osteosarcoma; Pilot Projects; Survival Analysis; Treatment Outcome; Vincristine | 1993 |
Neoadjuvant chemotherapy for patients with osteosarcoma: University of Florida studies.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Florida; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Life Tables; Lung Neoplasms; Methotrexate; Osteosarcoma; Survival Analysis; Treatment Outcome | 1993 |
Osteosarcoma: experience of the Tata Memorial Hospital, Bombay, India.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Developing Countries; Doxorubicin; Female; Humans; India; Lung Neoplasms; Male; Methotrexate; Middle Aged; Osteosarcoma; Retrospective Studies; Survival Rate; Treatment Outcome; Vinblastine | 1993 |
An opinion supporting the role of high-dose methotrexate in the treatment of osteosarcoma.
Topics: Acidosis, Renal Tubular; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care; Radionuclide Imaging; Retrospective Studies; Salvage Therapy; Thallium Radioisotopes; Treatment Outcome | 1993 |
Anaphylactoid reactions to methotrexate.
Topics: Adult; Anaphylaxis; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Pruritus; Urticaria | 1996 |
Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma. Analysis of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Survival Rate | 1996 |
[Methotrexate-leucovorin rescue therapy: pharmacological characteristics and clinical effective use].
Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Synergism; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Osteosarcoma | 1996 |
Problems and controversies in the management of childhood sarcomas.
Topics: Amputation, Surgical; Antineoplastic Agents; Child; Child, Preschool; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Rhabdomyosarcoma; Sarcoma | 1996 |
Chemotherapy for osteosarcoma and Ewing's sarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic; Research Design; Sarcoma, Ewing | 1997 |
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Combined Modality Therapy; Decision Making; Humans; Methotrexate; Osteosarcoma; Treatment Outcome | 1997 |
The success and failure of multimodal therapy for cancer in children.
Topics: Adolescent; Age Factors; Child; Dactinomycin; Humans; Lymph Node Excision; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Osteosarcoma; Prognosis; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Testicular Neoplasms; Vincristine; Wilms Tumor | 1975 |
Chemotherapy of solid tumors. Recent advances.
Topics: Adult; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Child; Cyclophosphamide; Doxorubicin; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunotherapy; Leucovorin; Male; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Prednisone; Rhabdomyosarcoma; Testicular Neoplasms; Thiotepa; Vinblastine; Vincristine | 1976 |
[Therapy of sarcomas].
Topics: Adolescent; Adult; Bone Neoplasms; Child; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Osteosarcoma; Remission, Spontaneous; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine | 1978 |
[(Management of acute toxicity after high dose methotrexate therapy)].
Topics: Adolescent; Blood Transfusion; Brain; Dose-Response Relationship, Drug; Female; Fluid Therapy; Furosemide; Humans; Kidney; Leucovorin; Leukopenia; Methotrexate; Osteosarcoma | 1979 |
Progress in the treatment of osteosarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Cell Division; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy; Time Factors | 1977 |
Multidrug chemotherapy in primary treatment of osteosarcoma. An editorial commentary.
Topics: Amputation, Surgical; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1976 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine | 1976 |
Dialyzable transfer factor in the treatment of human osteosarcoma: an analytic review.
Topics: Animals; Antineoplastic Agents; Biological Assay; Bone Neoplasms; Cell Extracts; Chemical Fractionation; Chemical Phenomena; Chemistry; Cytotoxicity Tests, Immunologic; Dialysis; Doxorubicin; Humans; Immunity, Cellular; Methotrexate; Osteosarcoma; T-Lymphocytes; Transfer Factor; Tuberculin Test | 1976 |
Neoplasms of the shoulder girdle.
Topics: Adult; Amputation, Surgical; Bone Neoplasms; Child; Chondroblastoma; Chondrosarcoma; Cryosurgery; Curettage; Eosinophilic Granuloma; Humans; Humerus; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Scapula; Shoulder | 1975 |
The potential of combined modality approaches for the treatment of malignant bone tumors in children.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Immunotherapy; Infant; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiography; Sarcoma, Ewing | 1975 |
Current therapies in osteosarcoma.
Topics: Adjuvants, Pharmaceutic; Adult; Animals; Bone Neoplasms; Child; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Immunotherapy; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1975 |
Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Methotrexate; Myelodysplastic Syndromes; Osteosarcoma | 1991 |
Local control and survival from the Cooperative Osteosarcoma Study Group studies of the German Society of Pediatric Oncology and the Vienna Bone Tumor Registry.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Austria; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Germany; Humans; Ifosfamide; Interferon Type I; Male; Methotrexate; Osteosarcoma; Registries; Societies, Medical; Survival Rate; Switzerland; Vincristine | 1991 |
Current management, local management, and survival statistics of high-grade osteosarcoma. Experience in Japan.
Topics: Adult; Aged; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Humans; Japan; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Osteotomy; Survival Analysis; Survival Rate | 1991 |
Osteogenic osteosarcoma: a model of curable disease by multidisciplinary approach of treatment.
Topics: Bone Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma | 1990 |
Osteosarcoma--is there a role for oral low-dose methotrexate.
Topics: Administration, Oral; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma | 1989 |
Chemotherapy for the primary treatment of osteosarcoma: population effectiveness over 20 years.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Osteosarcoma; Registries; Regression Analysis; United Kingdom | 1988 |
The role of methotrexate in osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma | 1988 |
[Methotrexate in pediatric hemato-oncology].
Topics: Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Nervous System Diseases; Osteosarcoma | 1987 |
Adjuvant therapy in the treatment of osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Osteosarcoma | 1986 |
Treatment-related leukoencephalopathy. A study of three cases and literature review.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Brain Neoplasms; Cytarabine; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 1986 |
Indications for and benefits of intensive therapies in treatment of childhood cancers.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Etoposide; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Risk; Sarcoma, Ewing | 1986 |
Osteosarcoma: fifteen years later.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Leucovorin; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Prostheses and Implants; Random Allocation | 1985 |
The therapy of osteogenic sarcoma: current status and thoughts for the future.
Topics: Age Factors; Aged; Bone Neoplasms; Doxorubicin; Female; Humans; Immunotherapy; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Sex Factors; Time Factors | 1972 |
130 trial(s) available for methotrexate and Osteogenic Sarcoma
| Article | Year |
|---|---|
A phase II trial evaluating the feasibility of adding bevacizumab to standard osteosarcoma therapy.
Topics: Adolescent; Amputation, Surgical; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Limb Salvage; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Survival Rate; Time Factors; Vascular Endothelial Growth Factor A; Wound Healing; Young Adult | 2017 |
Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Diphosphonates; Doxorubicin; Etoposide; Female; France; Humans; Ifosfamide; Imidazoles; Kaplan-Meier Estimate; Male; Methotrexate; Neutropenia; Osteosarcoma; Young Adult; Zoledronic Acid | 2018 |
Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin-Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin.
Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cross-Over Studies; Doxorubicin; Female; Hearing; Hearing Loss; Humans; Kidney; Male; Methotrexate; Organic Cation Transporter 2; Osteosarcoma; Pantoprazole; Young Adult | 2018 |
A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Child; Female; Gene Expression Regulation; Humans; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Osteosarcoma; Polymorphism, Single Nucleotide; Prospective Studies | 2018 |
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cohort Studies; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Survival Rate | 2019 |
Addition of Zoledronate to Chemotherapy in Patients with Osteosarcoma Treated with Limb-Sparing Surgery: A Phase III Clinical Trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; China; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Survival Rate; Zoledronic Acid | 2019 |
Results of API-AI based regimen in osteosarcoma adult patients included in the French OS2006/Sarcome-09 study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Follow-Up Studies; France; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Survival Rate; Young Adult; Zoledronic Acid | 2020 |
Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: a phase II trial in Japan.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Infant; Infant, Newborn; Japan; Limb Salvage; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome; Young Adult | 2013 |
Combination of 18F-FDG PET/CT and diffusion-weighted MR imaging as a predictor of histologic response to neoadjuvant chemotherapy: preliminary results in osteosarcoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Diffusion Magnetic Resonance Imaging; Doxorubicin; Female; Fluorodeoxyglucose F18; Humans; Male; Methotrexate; Middle Aged; Multimodal Imaging; Neoadjuvant Therapy; Osteosarcoma; Pilot Projects; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2013 |
Treatment of large osteosarcoma in children: new approach.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Precision Medicine; Treatment Outcome; Ultrasonography, Doppler | 2013 |
High-dose chemotherapy with stem cell rescue in the primary treatment of metastatic and pelvic osteosarcoma: final results of the ISG/SSG II study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Grading; Neoplasm Metastasis; Osteosarcoma; Pelvic Neoplasms; Pilot Projects; Prognosis; Stem Cell Transplantation; Survival Rate; Young Adult | 2014 |
Experience of pediatric osteosarcoma of the extremity at a single institution in Taiwan: prognostic factors and impact on survival.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Taiwan | 2015 |
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Interferon-alpha; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Polyethylene Glycols; Quality of Life; Research Design; Young Adult | 2015 |
Comparative outcome of Thai pediatric osteosarcoma treated with two protocols: the role of high-dose methotrexate (HDMTX) in a single institute experience.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Dose-Response Relationship, Drug; Etoposide; Extremities; Feasibility Studies; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Maximum Tolerated Dose; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate | 2014 |
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Respons
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asia; Australia; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease Progression; Disease-Free Survival; Doxorubicin; Europe; Female; Humans; Interferon alpha-2; Interferon-alpha; Kaplan-Meier Estimate; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Grading; North America; Osteosarcoma; Osteotomy; Polyethylene Glycols; Proportional Hazards Models; Recombinant Proteins; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2015 |
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate | 2015 |
Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cohort Studies; Doxorubicin; Humans; Methotrexate; Middle Aged; Neoplasm Grading; Osteosarcoma; Retrospective Studies; Young Adult | 2016 |
Evaluation of chemotherapy response in osteosarcoma with FDG-PET.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Fluorodeoxyglucose F18; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome; Young Adult | 2009 |
Sex- and age-related chemotherapy toxicity in patients with non-metastatic osteosarcoma.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Sex Factors; Young Adult | 2009 |
Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma.
Topics: Acute Kidney Injury; Adolescent; Adult; Alkalosis; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Kidney; Kidney Function Tests; Male; Methotrexate; Osmolar Concentration; Osteosarcoma; Water Intoxication; Young Adult | 2010 |
Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma.
Topics: Adolescent; Adult; Alkaline Phosphatase; Antineoplastic Agents; Biomarkers; Child; Child, Preschool; Cisplatin; Collagen Type I; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Male; Methotrexate; Osteocalcin; Osteosarcoma; Young Adult | 2010 |
Addition of pamidronate to chemotherapy for the treatment of osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Diphosphonates; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Male; Methotrexate; Osteosarcoma; Pamidronate | 2011 |
Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Femur; Humans; Humerus; Ifosfamide; Male; Methotrexate; Osteosarcoma; Tibia | 2012 |
Bayesian estimation of methotrexate pharmacokinetic parameters and area under the curve in children and young adults with localised osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bayes Theorem; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Linear Models; Methotrexate; Models, Biological; Osteosarcoma; Retrospective Studies; Software | 2002 |
Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Humans; Leucovorin; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Analysis; Treatment Outcome | 2003 |
Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Leg; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Treatment Outcome | 2003 |
Unstratified chemotherapy for non-metastatic osteosarcoma of the extremities in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Epirubicin; Etoposide; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Statistics, Nonparametric; Survival Analysis; Taiwan; Treatment Outcome | 2003 |
High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Ifosfamide; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Treatment Outcome | 2004 |
Glomerular dysfunction, independent of tubular dysfunction, induced by antineoplastic chemotherapy in children.
Topics: Acute Disease; Adolescent; Albuminuria; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Creatinine; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Glomerular Filtration Rate; Humans; Kidney Tubules; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Proteinuria; Rhabdomyosarcoma; Vincristine | 2004 |
Twenty-year follow-up of osteosarcoma of the extremity treated with adjuvant chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Morbidity; Osteosarcoma; Risk Factors; Vincristine | 2004 |
Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Infant; Male; Methotrexate; Osteosarcoma; Prospective Studies | 2005 |
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Follow-Up Studies; Heart Failure; Humans; Ifosfamide; Italy; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Patient Compliance; Prospective Studies; Renal Insufficiency; Scandinavian and Nordic Countries; Treatment Outcome | 2005 |
Metastatic osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Treatment Outcome | 2006 |
Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: prognostic factors and impact on survival.
Topics: Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brazil; Carboplatin; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Epirubicin; Female; Humans; Ifosfamide; Limb Salvage; Lung Neoplasms; Male; Methotrexate; Multivariate Analysis; Orthopedic Procedures; Osteosarcoma; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Survival Analysis; Treatment Outcome | 2006 |
SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Preoperative Care | 2007 |
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Infant; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate | 2008 |
Adjuvant chemotherapy in osteosarcoma - effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin. Preliminary results of the COSS 80 study.
Topics: Adult; Antineoplastic Agents; Bone Neoplasms; Cisplatin; Clinical Trials as Topic; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Interferons; Methotrexate; Osteosarcoma; Preoperative Care; Random Allocation | 1983 |
Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Humans; Interferon Type I; Male; Methotrexate; Osteosarcoma; Prognosis | 1984 |
Primary osteogenic sarcoma of the femur: a model for the use of preoperative chemotherapy in high risk malignant tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Premedication; Prognosis | 1984 |
Newer techniques in cancer chemotherapy.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Cells, Cultured; Child; Cisplatin; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Hepatic Artery; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Mechlorethamine; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Osteosarcoma; Peritoneal Cavity; Pleura | 1984 |
In search of an effective antiemetic: a nusring staff participates in marijuana research.
Topics: Adult; Antiemetics; Attitude of Health Personnel; Clinical Trials as Topic; Double-Blind Method; Dronabinol; Humans; Methotrexate; Nausea; Nurses; Osteosarcoma; Random Allocation; Vomiting | 1980 |
Toxicity associated with combination chemotherapy for osteosarcoma: a report of the cooperative osteosarcoma study (COSS 80).
Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Agents; Body Weight; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Osteosarcoma | 1983 |
[Clinico-pharmacological studies on the course of high-dose methotrexate therapy in childhood. A retrospective comparison of centers].
Topics: Adolescent; Bone Marrow; Bone Neoplasms; Cancer Care Facilities; Child; Chondrosarcoma; Clinical Trials as Topic; Germany, West; Humans; Methotrexate; Osteosarcoma; Retrospective Studies | 1984 |
A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma.
Topics: Adult; Amputation, Surgical; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Pilot Projects; Prognosis; Random Allocation | 1984 |
Treatment of patients with metastatic osteogenic sarcoma: a report from the Children's Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Kidney Diseases; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Neutropenia; Osteosarcoma; Thrombocytopenia; Time Factors; Vincristine | 1984 |
Is it ethical not to conduct a prospectively controlled trial of adjuvant chemotherapy in osteosarcoma?
Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Ethics, Medical; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Prospective Studies; Random Allocation; Tomography, X-Ray Computed | 1982 |
[Aggressive cytostatic treatment of osteogenic sarcoma in childhood (author's transl)].
Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Vincristine | 1981 |
Methotrexate as adjuvant treatment for primary osteosarcoma.
Topics: Bone Neoplasms; Clinical Trials as Topic; Humans; Methotrexate; Osteosarcoma; Postoperative Care | 1980 |
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma | 1980 |
Osteogenic sarcoma studies by the Cancer and Leukemia Group B.
Topics: Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma | 1981 |
Treatment of soft tissue and bone sarcomas: review of studies at the National Cancer Institute.
Topics: Antineoplastic Agents; Bone Neoplasms; Cardiomyopathies; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; National Institutes of Health (U.S.); Osteosarcoma; Prospective Studies; Random Allocation; Sarcoma; Soft Tissue Neoplasms; United States | 1981 |
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma | 1981 |
The multi-institutional osteosarcoma study: an update.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Life Tables; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; United States | 1993 |
Osteosarcoma in adolescents and young adults: new developments and controversies. The Childrens Cancer Group (CCG) studies.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; United States; Vincristine | 1993 |
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: the recent experience at the Rizzoli Institute.
Topics: Actuarial Analysis; Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Extremities; Female; Humans; Italy; Male; Methotrexate; Necrosis; Osteosarcoma; Prognosis; Salvage Therapy; Survival Analysis | 1993 |
Chemotherapy in osteogenic sarcoma: the experience of the Pediatric Department of the Gustave Roussy Institute.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Feasibility Studies; Female; France; Humans; Ifosfamide; Leucovorin; Male; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; Vincristine | 1993 |
Osteosarcoma of the limb: an institutional report of 10 years experience with neoadjuvant chemotherapy and delayed surgery.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Life Tables; Methotrexate; Osteosarcoma; Treatment Outcome; Vincristine | 1993 |
Safety and efficacy of l-leucovorin rescue following high-dose methotrexate for osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Stereoisomerism | 1995 |
[Fast neutron treatment of osteosarcoma].
Topics: Adolescent; Adult; Chemotherapy, Adjuvant; Child; Cobalt Radioisotopes; Combined Modality Therapy; Fast Neutrons; Female; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Radiotherapy Dosage | 1994 |
Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disarticulation; Doxorubicin; Europe; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome; Vincristine | 1993 |
The European Osteosarcoma Intergroup (E.O.I.) studies 1980-1991.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Europe; Humans; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome | 1993 |
An update of Scandinavian studies of osteosarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Scandinavian and Nordic Countries; Survival Rate; Treatment Outcome | 1993 |
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Humans; Ifosfamide; Life Tables; Male; Methotrexate; Minnesota; Necrosis; Osteosarcoma; Pilot Projects; Survival Analysis; Treatment Outcome; Vincristine | 1993 |
Neoadjuvant chemotherapy for patients with osteosarcoma: University of Florida studies.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Florida; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Life Tables; Lung Neoplasms; Methotrexate; Osteosarcoma; Survival Analysis; Treatment Outcome | 1993 |
Influence of adriamycin dose in the outcome of patients with osteosarcoma treated with multidrug neoadjuvant chemotherapy: results of two sequential studies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Complications | 1993 |
[Effect of high and low doses of methotrexate (MTX) on bone mass in subjects treated for osteosarcoma of the limbs].
Topics: Adolescent; Adult; Bone Density; Bone Neoplasms; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma | 1993 |
Intra-arterial versus intravenous cisplatinum (in addition to systemic Adriamycin and high dose methotrexate) in the neoadjuvant treatment of osteosarcoma of the extremities. results of a randomized study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Injections, Intra-Arterial; Injections, Intravenous; Male; Methotrexate; Osteosarcoma | 1996 |
Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Extremities; Humans; Methotrexate; Osteosarcoma; Vincristine | 1997 |
The importance of doxorubicin and methotrexate dose intensity in the chemotherapy of osteosarcoma.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Osteosarcoma; Retrospective Studies; Survival Rate; Treatment Outcome | 1996 |
Long-term follow-up and post-relapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Extremities; Female; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Male; Methotrexate; Osteosarcoma | 1997 |
Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leg; Male; Methotrexate; Osteosarcoma; Prognosis; Surgical Procedures, Operative; Treatment Outcome | 1997 |
Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Necrosis; Osteosarcoma; Time Factors; Treatment Outcome | 1998 |
Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Creatinine; Female; Humans; Ifosfamide; Kidney Diseases; Kidney Function Tests; Male; Methotrexate; Osteosarcoma | 1998 |
Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Leg; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Risk Factors; Survival Analysis; Treatment Outcome | 1998 |
Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Female; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Osteosarcoma; Time Factors | 1998 |
Local host response in osteosarcoma after chemotherapy referred to radiographs, CT, tumour necrosis and patient survival.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Infant; Infant, Newborn; Male; Mesna; Methotrexate; Middle Aged; Necrosis; Neoadjuvant Therapy; Osteosarcoma; Predictive Value of Tests; Prognosis; Tomography, X-Ray Computed | 1998 |
Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Bone Neoplasms; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prospective Studies | 1999 |
Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care; Prognosis; Registries; Scandinavian and Nordic Countries | 1999 |
High-dose methotrexate and HELP [Holoxan (ifosfamide), eldesine (vindesine), platinum]--doxorubicin in non-metastatic osteosarcoma of the extremity: a French multicentre pilot study. Fédération Nationale des Centres de Lutte contre le Cancer and Société F
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; France; Humans; Ifosfamide; Male; Methotrexate; Necrosis; Osteosarcoma; Pilot Projects; Prognosis; Survival Rate; Time Factors; Vindesine | 1999 |
Long-term results after combined modality treatment for non-metastatic osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Treatment Outcome | 1999 |
Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis.
Topics: Adult; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Leucovorin; Lung Neoplasms; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 2000 |
Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Extremities; Female; Fertility; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Osteosarcoma; Patient Compliance; Plastic Surgery Procedures; Postoperative Complications; Radiography; Reoperation; Survival Rate | 2000 |
Received dose and dose-intensity of chemotherapy and outcome in nonmetastatic extremity osteosarcoma. European Osteosarcoma Intergroup.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome | 2000 |
A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate | 2001 |
Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Proportional Hazards Models; Risk Assessment | 2001 |
High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: preliminary results of an Italian Sarcoma Group/Scandinavian Sarcoma Group pilot study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chondrocytes; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Fibroblasts; Follow-Up Studies; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoadjuvant Therapy; Osteoblasts; Osteosarcoma; Pilot Projects; Preoperative Care; Prognosis; Survival Rate | 2002 |
Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? A study on 570 patients of two consecutive trials of the European Osteosarcoma Intergroup.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Humans; Infant; Infant, Newborn; Methotrexate; Osteosarcoma; Risk Factors; Survival Analysis; Treatment Outcome | 2002 |
Treatment of osteogenic sarcoma. II. Aggressive resection of pulmonary metastases.
Topics: Antineoplastic Agents; Bone Neoplasms; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonectomy; Thoracic Surgery; Thorax | 1979 |
Randomized trial of adjuvant chemotherapy in osteogenic osteosarcoma: comparison of altering sequential administrations of high doses of adriamycin, methotrexate, and cyclophosphamide with a 6-month administration of high-dose adriamycin followed by a low
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Random Allocation | 1978 |
Delata-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation.
Topics: Adolescent; Adult; Antiemetics; Double-Blind Method; Dronabinol; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Osteosarcoma; Placebos; Prospective Studies; Vomiting | 1979 |
Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation.
Topics: Adolescent; Adult; Age Factors; BCG Vaccine; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma | 1979 |
Adjuvant therapy for osteosarcoma: preoperative and postoperative treatment.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Care; Preoperative Care; Time Factors | 1978 |
Local en bloc resection for limb preservation.
Topics: Adolescent; Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Joint Prosthesis; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1978 |
Sequential combination chemotherapy (containing high-dose cyclophosphamide) for metastic osteogenic sarcoma.
Topics: Adolescent; Bone Neoplasms; Child; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
Combination chemotherapy for osteosarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Time Factors | 1978 |
High-dose methotrexate in osteogenic sarcoma: a 5-year experience.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Time Factors; Vincristine | 1978 |
Adjuvant chemotherapy for osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1978 |
Adjuvant therapy for nonmetastatic osteogenic sarcoma: an evaluation of transfer factor versus combination chemotherapy.
Topics: Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Transfer Factor; Vincristine | 1978 |
Safety of delayed leucovorin "rescue" following high-dose methotrexate in children.
Topics: Adult; Child; Child, Preschool; Clinical Trials as Topic; Humans; Leucovorin; Methotrexate; Osteosarcoma; Time Factors | 1978 |
Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Humans; Infusions, Parenteral; Kinetics; Leucovorin; Leukemia, Lymphoid; Methotrexate; Osteosarcoma; Time Factors | 1978 |
Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity: a 6 year report.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Recurrence; Vincristine | 1979 |
[Results of chemotherapy of osteosarcoma].
Topics: Adolescent; Adult; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Femoral Neoplasms; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Vincristine | 1979 |
Progress in the treatment of osteosarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Cell Division; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy; Time Factors | 1977 |
Transfer factor versus combination chemotherapy: a preliminary report of a randomized postsurgical adjuvant treatment study in osteogenic sarcoma.
Topics: Antineoplastic Agents; B-Lymphocytes; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Humans; Hypersensitivity, Delayed; Lymphocyte Activation; Methotrexate; Osteosarcoma; Skin Tests; T-Lymphocytes; Transfer Factor; Vincristine | 1976 |
A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Extremities; Feasibility Studies; Female; Humans; Male; Methotrexate; Osteosarcoma; Patient Compliance; Pilot Projects; Treatment Outcome | 1992 |
Effect of chemotherapy combined with caffeine for osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Calcaneus; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Salvage Therapy; Tibia | 1992 |
Effect of intra-arterial versus intravenous cisplatin in addition to systemic adriamycin and high-dose methotrexate on histologic tumor response of osteosarcoma of the extremities.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prospective Studies | 1992 |
[Effects of hydration on plasma concentrations of methotrexate in patients with osteosarcoma treated with high doses of methotrexate].
Topics: Adult; Bone Neoplasms; Child; Extremities; Female; Fluid Therapy; Glucose Solution, Hypertonic; Humans; Infusions, Intravenous; Kidney; Leucovorin; Male; Methotrexate; Osteosarcoma | 1992 |
The treatment of osteosarcoma: present trends. The Scandinavian Sarcoma Group experience.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Drug Therapy; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies; Scandinavian and Nordic Countries; Survival Rate | 1992 |
Local control and survival from the Cooperative Osteosarcoma Study Group studies of the German Society of Pediatric Oncology and the Vienna Bone Tumor Registry.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Austria; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Germany; Humans; Ifosfamide; Interferon Type I; Male; Methotrexate; Osteosarcoma; Registries; Societies, Medical; Survival Rate; Switzerland; Vincristine | 1991 |
Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Intraoperative Period; Male; Methotrexate; Osteosarcoma; Prospective Studies; Recurrence; Remission Induction; Sarcoma, Ewing; Vincristine | 1991 |
[Alternative chemotherapy of malignant bone neoplasms in children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Organoplatinum Compounds; Osteosarcoma; Sarcoma, Ewing; Vincristine | 1990 |
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Italy; Methotrexate; Necrosis; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prostheses and Implants; Survival Rate; Telangiectasis | 1991 |
Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma | 1990 |
[The combination treatment of malignant bone tumors using fast neutrons].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carubicin; Chondrosarcoma; Chordoma; Combined Modality Therapy; Fast Neutrons; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Survival Rate | 1990 |
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience.
Topics: Child; Cisplatin; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis | 1990 |
Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Period; Preoperative Care; Prognosis; Random Allocation | 1988 |
[Scintigraphic follow-up of osteosarcoma during neoadjuvant chemotherapy. Results of the cooperative osteosarcoma study of the Society for Pediatric Oncology].
Topics: Adolescent; Adult; Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Radionuclide Imaging; Technetium Tc 99m Medronate | 1988 |
A trial of chemotherapy in patients with osteosarcoma (a report to the Medical Research Council by their Working Party on Bone Sarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Prognosis; Vincristine | 1986 |
The role of methotrexate in osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma | 1988 |
Adjuvant therapy of osteosarcoma.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Methotrexate; Osteosarcoma; Random Allocation | 1987 |
A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Clinical Trials as Topic; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Prognosis; Random Allocation; Time Factors; Vincristine | 1987 |
Adjuvant therapy in the treatment of osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Osteosarcoma | 1986 |
The relationship of various aspects of surgical management to outcome in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radius; Random Allocation; Tibia; Vincristine | 1988 |
High-dose methotrexate in osteosarcoma--Mayo Clinic studies.
Topics: Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis | 1987 |
Adriamycin-methotrexate high dose versus adriamycin-methotrexate moderate dose as adjuvant chemotherapy for osteosarcoma of the extremities: a randomized study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Evaluation; Extremities; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Random Allocation | 1986 |
Comparison of intra-arterial cis-diamminedichloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Humans; Infusions, Intra-Arterial; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Random Allocation | 1985 |
Osteosarcoma: fifteen years later.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Leucovorin; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Prostheses and Implants; Random Allocation | 1985 |
[Chemotherapy of osteogenic sarcoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma | 1985 |
Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma.
Topics: Amputation, Surgical; Bone Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Femoral Neoplasms; Follow-Up Studies; Humans; Injections, Intramuscular; Injections, Intravenous; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Time Factors; Vincristine | 1974 |
721 other study(ies) available for methotrexate and Osteogenic Sarcoma
| Article | Year |
|---|---|
TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Methotrexate; Mice; Osteosarcoma; Response Evaluation Criteria in Solid Tumors; STAT1 Transcription Factor; Succinate Dehydrogenase; Transforming Growth Factor beta; Up-Regulation; Warburg Effect, Oncologic; Xenograft Model Antitumor Assays | 2021 |
Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carbon-Sulfur Lyases; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays | 2022 |
Risk Factors for Hepatic Toxicity of High-dose Methotrexate in Patients With Osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Female; History, 21st Century; Humans; Japan; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Young Adult | 2022 |
Unexpected severe hepatic and skin toxicities during high dose methotrexate course for osteosarcoma.
Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Osteosarcoma; Renal Insufficiency; Stevens-Johnson Syndrome | 2022 |
Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study.
Topics: Adolescent; Amputation, Surgical; Antineoplastic Agents; Asia, Southeastern; Bone Neoplasms; Child; Female; Humans; Limb Salvage; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Socioeconomic Factors; Treatment Outcome | 2022 |
Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223.
Topics: Adolescent; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Polycomb Repressive Complex 1; Proto-Oncogene Proteins c-bcl-2; Quercetin; Tumor Suppressor Protein p53 | 2022 |
Thymoquinone Augments Methotrexate-Induced Apoptosis on Osteosarcoma Cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Bone Neoplasms; Caspase 9; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2 | 2022 |
Polydopamine-modified ZIF-8 nanoparticles as a drug carrier for combined chemo-photothermal osteosarcoma therapy.
Topics: Bone Neoplasms; Doxorubicin; Drug Carriers; Drug Liberation; Humans; Indoles; Methotrexate; Nanoparticles; Osteosarcoma; Phototherapy; Photothermal Therapy; Polymers | 2022 |
Prevalence and management of methotrexate-induced neurotoxicity in pediatric patients with osteosarcoma: a single-center experience.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Prevalence; Retrospective Studies; Young Adult | 2022 |
Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy.
Topics: Bone Neoplasms; Female; Humans; Ki-67 Antigen; Leukopenia; Methotrexate; Nomograms; Osteosarcoma | 2022 |
Thymoquinone Potentiates Methotrexate Mediated-Apoptosis in Saos-2 Osteosarcoma Cell Line.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2 | 2022 |
Osteosarcoma and causes of death: A report of 1520 deceased patients from the Cooperative Osteosarcoma Study Group (COSS).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cause of Death; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma | 2022 |
Establishment and Characterization of Single and Triple-Agent Resistant Osteosarcoma Cell Lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Humans; Methotrexate; Osteosarcoma | 2023 |
LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Pseudogenes; RNA, Long Noncoding | 2022 |
Peri-osteosarcoma adipose computed tomography attenuation and volume for predicting chemotherapy response in pediatric patients.
Topics: Bone Neoplasms; Child; Humans; Inflammation; Methotrexate; Osteosarcoma; Retrospective Studies; Tomography | 2023 |
Neurocognitive outcomes of children with osteosarcoma treated with methotrexate.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Methotrexate; Osteosarcoma | 2023 |
Predicting chemosensitivity based on mini patient-derived xenografts in osteosarcoma patients: A retrospective study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Heterografts; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Retrospective Studies | 2023 |
Effect of co-medications and potential risk factors of high-dose methotrexate-mediated acute hepatotoxicity in patients with osteosarcoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Disease Progression; Female; Humans; Methotrexate; Osteosarcoma; Proton Pump Inhibitors; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 2023 |
Outcomes and survival rates of childhood osteosarcoma in Iran, A report from MAHAK Pediatric Cancer Treatment and Research Center, from 2007 to 2020.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Iran; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Survival Rate | 2023 |
A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy.
Topics: Cysteine; Drug Combinations; Drug Interactions; Drug Monitoring; Female; Glycine; Glycyrrhetinic Acid; Humans; Leukemia; Logistic Models; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Vincristine | 2020 |
Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors | 2020 |
Combinational delivery of anticancer drugs for osteosarcoma treatment using electrosprayed core shell nanocarriers.
Topics: Antineoplastic Agents; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Methotrexate; Nanostructures; Osteosarcoma | 2020 |
Impact of chemotherapy-induced necrosis on event-free and overall survival after preoperative MAP chemotherapy in patients with primary high-grade localized osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Correlation of Data; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Necrosis; Neoadjuvant Therapy; Osteosarcoma; Preoperative Period; Retrospective Studies; Survival Rate; Young Adult | 2020 |
Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; GTP Phosphohydrolases; Humans; Membrane Proteins; Methotrexate; MicroRNAs; Neoplasm Invasiveness; Osteosarcoma; RNA, Circular | 2020 |
Methotrexate-induced epidermal necrosis in a child with osteosarcoma.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Humans; Male; Methotrexate; Necrosis; Osteosarcoma | 2020 |
miR-192 enhances sensitivity of methotrexate drug to MG-63 osteosarcoma cancer cells.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Signal Transduction | 2020 |
Clinical factors affecting prognosis of limb osteosarcoma in China: a multicenter retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; China; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Young Adult | 2020 |
Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an osteosarcoma patient.
Topics: Adolescent; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Piperacillin; Renal Insufficiency | 2021 |
IAP Chemotherapy Regimen Is a Viable and Cost-effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cost-Benefit Analysis; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Salvage Therapy | 2021 |
Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; GTP-Binding Proteins; Humans; Methotrexate; MicroRNAs; Molecular Targeted Therapy; Osteosarcoma; Protein Glutamine gamma Glutamyltransferase 2; RNA, Circular; Transglutaminases | 2021 |
The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteoclasts; Osteosarcoma; Osteotomy; Risk Factors; Tumor Microenvironment; Young Adult | 2021 |
Clinical therapeutic effects of combined methotrexate and other chemotherapeutic agents in treating children and young patients with osteosarcoma: A protocol for systematic review and meta-analysis.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Male; Meta-Analysis as Topic; Methotrexate; Osteosarcoma; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic; Treatment Outcome; Young Adult | 2021 |
Effect assessment of methotrexate in combination with other chemotherapeutic agents for osteosarcoma in children: A protocol for systematic review and meta-analysis.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Disease-Free Survival; Humans; Meta-Analysis as Topic; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Randomized Controlled Trials as Topic; Survival Rate; Systematic Reviews as Topic; Time Factors | 2021 |
A possible interaction between favipiravir and methotrexate: Drug-induced hepatotoxicity in a patient with osteosarcoma.
Topics: Amides; Antiviral Agents; Bone Neoplasms; Chemical and Drug Induced Liver Injury; COVID-19; Humans; Methotrexate; Osteosarcoma; Pharmaceutical Preparations; Pyrazines; RNA, Viral; SARS-CoV-2 | 2022 |
Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Extremities; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Soft Tissue Neoplasms | 2021 |
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
Topics: Adolescent; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; China; Female; Genotype; Humans; Infant; Lymphoma; Lymphoproliferative Disorders; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Osteosarcoma; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
High dose methotrexate containing regimen in pediatric non-metastatic extremity osteosarcoma patients: experience from a tertiary cancer center in India.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Extremities; Humans; Methotrexate; Osteosarcoma | 2022 |
Investigating Optimal Chemotherapy Options for Osteosarcoma Patients through a Mathematical Model.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Decision-Making; Cytotoxicity, Immunologic; Decision Support Techniques; Dendritic Cells; Doxorubicin; Drug Administration Schedule; HMGB1 Protein; Humans; Interferon-gamma; Lymphocytes, Tumor-Infiltrating; Methotrexate; Models, Theoretical; Osteosarcoma; Patient Selection; Precision Medicine; T-Lymphocytes, Helper-Inducer; Time Factors; Tumor Microenvironment | 2021 |
Effectiveness of nanoencapsulated methotrexate against osteosarcoma cells: in vitro cytotoxicity under dynamic conditions.
Topics: Antineoplastic Agents; Capsules; Cell Line, Tumor; Drug Carriers; Humans; Lab-On-A-Chip Devices; Lipids; Methotrexate; Nanostructures; Osteosarcoma | 2017 |
Diffuse Marrow Involvement in Metastatic Osteosarcoma: An Unusual Presentation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 2017 |
Poloxamer surface modified trimethyl chitosan nanoparticles for the effective delivery of methotrexate in osteosarcoma.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Endocytosis; Humans; Methotrexate; Nanoparticles; Osteosarcoma; Poloxamer | 2017 |
Fertility, Cardiac, and Orthopedic Challenges in Survivors of Adult and Childhood Sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Cancer Survivors; Cardiotoxicity; Child; Cisplatin; Dexrazoxane; Doxorubicin; Female; Humans; Infertility; Male; Methotrexate; Osteosarcoma | 2017 |
The role of the MTHFR C677T polymorphism in methotrexate-induced toxicity in pediatric osteosarcoma patients.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Homozygote; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Osteosarcoma; Pharmacogenetics; Polymorphism, Genetic; Retrospective Studies | 2017 |
Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Perioperative Care; Retrospective Studies; Young Adult | 2017 |
Methotrexate-F127 conjugated mesoporous zinc hydroxyapatite as an efficient drug delivery system for overcoming chemotherapy resistance in osteosarcoma cells.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Delivery Systems; Durapatite; Humans; Hydrogen-Ion Concentration; Methotrexate; Osteosarcoma; Polyethylenes; Polypropylenes; Zinc | 2017 |
Transition from Tumor Tissue to Bone Marrow in Patients with Appendicular Osteosarcoma after Neoadjuvant Chemotherapy.
Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; In Vitro Techniques; Limb Salvage; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Treatment Outcome; Young Adult | 2017 |
Outcomes in non-metastatic treatment naive extremity osteosarcoma patients treated with a novel non-high dosemethotrexate-based, dose-dense combination chemotherapy regimen 'OGS-12'.
Topics: Adolescent; Adult; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Developing Countries; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; India; Intention to Treat Analysis; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Proportional Hazards Models; Retrospective Studies; Time Factors; Treatment Outcome; Tumor Burden; Young Adult | 2017 |
Patient-derived osteosarcoma cells are resistant to methotrexate.
Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Bone Neoplasms; Cell Culture Techniques; Cells, Cultured; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Transplantation; Osteosarcoma; Young Adult | 2017 |
Ambulatory High-dose Methotrexate Administration in Pediatric Osteosarcoma Patients at a Single Institution in Argentina.
Topics: Adolescent; Algorithms; Ambulatory Care; Anemia; Antacids; Argentina; Chemical and Drug Induced Liver Injury; Child; Diarrhea; Female; Humans; Hydrogen-Ion Concentration; Leucovorin; Leukopenia; Male; Methotrexate; Mucositis; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia; Vomiting | 2017 |
MicroRNA-375 as a potential serum biomarker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma.
Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Case-Control Studies; Child; Doxorubicin; Female; Humans; Male; Methotrexate; MicroRNAs; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; ROC Curve; Survival Analysis; Treatment Outcome; Tumor Burden | 2018 |
Ceramic core with polymer corona hybrid nanocarrier for the treatment of osteosarcoma with co-delivery of protein and anti-cancer drug.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cattle; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Durapatite; Methotrexate; Nanoparticles; Osteosarcoma; Polyvinyl Alcohol; Serum Albumin, Bovine | 2018 |
Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis.
Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Osteosarcoma; RNA, Long Noncoding; Signal Transduction; Treatment Outcome | 2018 |
Delayed Methotrexate Clearance Despite Carboxypeptidase-G2 (Glucarpidase) Administration in 2 Patients With Toxic Methotrexate Levels.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma; Recombinant Proteins | 2018 |
Micrometastatic Drug Screening Platform Shows Heterogeneous Response to MAP Chemotherapy in Osteosarcoma Cell Lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Methotrexate; Neoplasm Micrometastasis; Osteosarcoma | 2018 |
S-phase kinase-associated protein 2 is involved in epithelial-mesenchymal transition in methotrexate-resistant osteosarcoma cells.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Osteosarcoma; S-Phase Kinase-Associated Proteins; Signal Transduction | 2018 |
Successful Treatment of Osteosarcoma Without Methotrexate in a 13-Year-Old Boy With Down Syndrome.
Topics: Adolescent; Bone Neoplasms; Down Syndrome; Humans; Male; Methotrexate; Osteosarcoma | 2019 |
Positive effects of antitumor drugs in combination with propolis on canine osteosarcoma cells (spOS-2) and mesenchymal stem cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Cell Line, Tumor; Cell Survival; Dogs; Doxorubicin; Mesenchymal Stem Cells; Methotrexate; Osteosarcoma; Propolis | 2018 |
The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome; Young Adult | 2018 |
The Efficiency and Toxicity of Mifamurtide in Childhood Osteosarcoma.
Topics: Acetaminophen; Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Phosphatidylethanolamines; Retrospective Studies; Survival Rate; Turkey | 2018 |
Outpatient High-dose Methotrexate for Osteosarcoma: It's Safe and Feasible, If You Want It.
Topics: Adolescent; Bone Neoplasms; Hospitalization; Humans; Methotrexate; Osteosarcoma; Outpatients; Patient Satisfaction; Prospective Studies; Treatment Outcome | 2019 |
2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity.
Topics: Adult; Female; gamma-Glutamyl Hydrolase; Humans; Hydrolysis; Kidney; Methotrexate; Osteosarcoma; Particle Size; Surface Properties | 2018 |
Outcomes in Treatment-Naïve Patients With Metastatic Extremity Osteosarcoma Treated With OGS-12, a Novel Non-High-Dose Methotrexate-Based, Dose-Dense Combination Chemotherapy, in a Tertiary Care Cancer Center.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Prospective Studies; Retrospective Studies; Survival Rate; Tertiary Healthcare; Treatment Outcome; Young Adult | 2018 |
miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.
Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen Type III; Down-Regulation; Drug Resistance, Neoplasm; Humans; Methotrexate; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Osteosarcoma; Up-Regulation | 2018 |
Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Bone Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult | 2019 |
Safety and efficacy of high-dose methotrexate for osteosarcoma in adolescents compared with young adults.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Treatment Outcome; Young Adult | 2019 |
Bone Sarcoma With
Topics: 12E7 Antigen; Adult; Amputation, Surgical; Biopsy; Bone Neoplasms; Chemotherapy, Adjuvant; Diagnosis, Differential; Femur; Gene Amplification; Humans; Male; Methotrexate; Oncogene Proteins, Fusion; Osteosarcoma; Sarcoma, Ewing; Treatment Outcome | 2019 |
SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription.
Topics: Animals; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Methotrexate; Mice; Osteosarcoma; Peptide Synthases | 2019 |
Clinical Prognostic Factors and Outcome in Pediatric Osteosarcoma: Effect of Delay in Local Control and Degree of Necrosis in a Multidisciplinary Setting in Lebanon.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Infant; Lebanon; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Retrospective Studies; Risk Assessment; Treatment Outcome | 2019 |
Reversible Impaired Methotrexate Clearance After Platinum-Based Chemotherapy for Osteosarcoma.
Topics: Adolescent; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Doxorubicin; Drug Interactions; Female; Humans; Kidney Diseases; Leucovorin; Methotrexate; Morphine; Mucositis; Osteosarcoma | 2019 |
Osteosarcoma around the knee treated with neoadjuvant chemotherapy and a custom-designed prosthesis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arthroplasty, Replacement, Knee; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Ifosfamide; Knee; Knee Joint; Knee Prosthesis; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prosthesis Design; Retrospective Studies; Young Adult | 2013 |
The correlation between dose of folinic acid and neurotoxicity in children and adolescents treated for osteosarcoma with high-dose methotrexate (HDMTX): a neuropsychological and psychosocial study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Male; Methotrexate; Neuropsychological Tests; Neurotoxicity Syndromes; Osteosarcoma; Young Adult | 2013 |
Carboplatin and doxorubicin in treatment of pediatric osteosarcoma: a 9-year single institute experience in the Northern Region of Thailand.
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Retrospective Studies; Risk Factors; Survival; Survival Rate; Thailand; Treatment Outcome | 2013 |
Single nucleotide polymorphisms in the NER pathway and clinical outcome of patients with bone malignant tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Cyclin H; DNA Helicases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endonucleases; Female; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Neoplasm Metastasis; Nuclear Proteins; Osteosarcoma; Poly-ADP-Ribose Binding Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prognosis; Survival Rate; Transcription Factors; Young Adult | 2013 |
Simple and reliable HPLC method for the monitoring of methotrexate in osteosarcoma patients.
Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Humans; Limit of Detection; Linear Models; Male; Methotrexate; Middle Aged; Osteosarcoma; Reproducibility of Results; Young Adult | 2014 |
Predictive impact of common variations in DNA repair genes on clinical outcome of osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; DNA Repair; DNA-Binding Proteins; Doxorubicin; Endonucleases; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Staging; Nuclear Proteins; Osteosarcoma; Polymorphism, Genetic; Prognosis; Transcription Factors; Young Adult | 2013 |
Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cloning, Molecular; Gene Expression; Gene Order; Genes, Reporter; Genetic Vectors; Humans; Lentivirus; Methotrexate; Organ Specificity; Osteocalcin; Osteosarcoma; Peptide Synthases; Promoter Regions, Genetic; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 2013 |
Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.
Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Infusions, Intravenous; Methotrexate; Osteosarcoma; Prognosis | 2014 |
Effect of variation of ABCB1 and ABCC3 genotypes on the survival of bone tumor cases after chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Polymorphism, Single Nucleotide; Prognosis; Survival Rate; Vincristine; Young Adult | 2013 |
Efficacy of glucarpidase (carboxypeptidase g2) in patients with acute kidney injury after high-dose methotrexate therapy.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; Compassionate Use Trials; Drug Administration Schedule; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Methotrexate; Osteosarcoma; Treatment Outcome | 2014 |
Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma | 2013 |
Drug-drug interaction between methotrexate and levetiracetam resulting in delayed methotrexate elimination.
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Levetiracetam; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Piracetam | 2014 |
Can high dose methotrexate be continued after severe hypersensitivity reaction?
Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Methotrexate; Osteosarcoma | 2014 |
Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathy.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Female; Hearing Loss; Humans; Ifosfamide; Magnetic Resonance Imaging; Methotrexate; Osteosarcoma | 2014 |
Extraskeletal Osteosarcoma: An International Rare Cancer Network Study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Chemotherapy, Adjuvant; Cisplatin; Cohort Studies; Deoxycytidine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Gemcitabine; Humans; Ifosfamide; Lower Extremity; Male; Methotrexate; Middle Aged; Mitomycin; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radiotherapy; Rare Diseases; Retroperitoneal Neoplasms; Retrospective Studies; Soft Tissue Neoplasms; Tumor Burden; Young Adult | 2016 |
[Value of ifosfamide in neoadjuvant therapy for osteosarcoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma | 2013 |
Is it important to maintain high-dose intensity chemotherapy in the treatment of adults with osteosarcoma?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Time Factors; Young Adult | 2014 |
Developing population pharmacokinetic parameters for high-dose methotrexate therapy: implication of correlations among developed parameters for individual parameter estimation using the Bayesian least-squares method.
Topics: Adolescent; Adult; Aged; Bayes Theorem; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Least-Squares Analysis; Lymphoma; Methotrexate; Middle Aged; Models, Statistical; Osteosarcoma; Patient-Specific Modeling; Retrospective Studies; Young Adult | 2014 |
Reticulated hyperpigmentation following chemotherapy for radiation-induced osteosarcoma.
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Eruptions; Etoposide; Humans; Hyperpigmentation; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasms, Radiation-Induced; Orbital Neoplasms; Osteosarcoma; Triamcinolone | 2014 |
Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Humans; Intracellular Signaling Peptides and Proteins; Methotrexate; Neoplasm Proteins; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induces apoptosis of osteosarcoma cells in vitro.
Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; Humans; Methotrexate; Osteosarcoma; Survival Rate | 2014 |
Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Organic Anion Transporters; Osteosarcoma; Polymorphism, Single Nucleotide; Survival Analysis; Treatment Outcome; Young Adult | 2014 |
Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Daunorubicin; Etoposide; Fluorouracil; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Humans; Integrin alphaVbeta3; Membrane Transport Modulators; Methotrexate; Osteopontin; Osteosarcoma; Phloretin; Up-Regulation | 2014 |
Metabolic markers of MG-63 osteosarcoma cell line response to doxorubicin and methotrexate treatment: comparison to cisplatin.
Topics: Amino Acids; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Membrane; Choline; Cisplatin; Doxorubicin; Energy Metabolism; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methotrexate; Molecular Structure; Multivariate Analysis; Nucleotides; Osteosarcoma | 2014 |
Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Survival Rate; Time Factors | 2014 |
High-dose methotrexate (HD-MTX) used as an adjunct with other chemotherapeutics for the treatment of osteosarcoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Child; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Prognosis; Recurrence; Retrospective Studies; Young Adult | 2015 |
Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Beclin-1; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Humans; Membrane Proteins; Methotrexate; Mice; Osteosarcoma; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
Pirarubicin versus doxorubicin in neoadjuvant/adjuvant chemotherapy for stage IIB limb high-grade osteosarcoma: does the analog matter?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Retrospective Studies; Young Adult | 2015 |
Population pharmacokinetics of high-dose methotrexate after intravenous administration in Chinese osteosarcoma patients from a single institution.
Topics: Adolescent; Adult; Child; Female; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Models, Molecular; Osteosarcoma; Young Adult | 2015 |
Halloysite nanotube-based drug delivery system for treating osteosarcoma.
Topics: Aluminum Silicates; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Clay; Drug Carriers; Humans; Methotrexate; Nanotubes; Osteosarcoma | 2014 |
Excision repair cross-complementation group 1 protein expression predicts survival in patients with high-grade, non-metastatic osteosarcoma treated with neoadjuvant chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; DNA-Binding Proteins; Doxorubicin; Endonucleases; Female; Humans; Ifosfamide; Immunohistochemistry; Kaplan-Meier Estimate; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Retrospective Studies | 2015 |
Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Drug Evaluation; Female; gamma-Glutamyl Hydrolase; Hematologic Neoplasms; Humans; Inactivation, Metabolic; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Male; Methotrexate; Osteosarcoma; Recombinant Proteins; Recovery of Function; Retrospective Studies; Young Adult | 2015 |
DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: the same outcome of treatment with different doses in sensitive cell lines.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Folic Acid Antagonists; Humans; Medulloblastoma; Methotrexate; Osteosarcoma; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase | 2015 |
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate.
Topics: Alleles; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Osteosarcoma; Polymorphism, Single Nucleotide; Replication Protein C; Tetrahydrofolate Dehydrogenase | 2015 |
Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Flow Cytometry; Humans; Melatonin; Methotrexate; Osteosarcoma | 2015 |
Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines.
Topics: Bone Neoplasms; Cell Line, Tumor; Databases, Genetic; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Protein Interaction Maps | 2015 |
Highly effective reduced toxicity dose-intensive pilot protocol for non-metastatic limb osteogenic sarcoma (SCOS 89).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Substitution; Etoposide; Female; Follow-Up Studies; Hearing Loss; Humans; Ifosfamide; Kidney Diseases; Leucovorin; Male; Methotrexate; Osteosarcoma; Pilot Projects; Stroke Volume; Survival Rate; Treatment Outcome; Young Adult | 2015 |
Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotonic Agents; Child; Child, Preschool; Cisplatin; Dexrazoxane; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Infant; Infant, Newborn; Male; Methotrexate; Osteosarcoma; Treatment Outcome; Ventricular Dysfunction | 2016 |
Second primary osteosarcomas in patients with retinoblastoma.
Topics: Adolescent; Adult; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Extremities; Female; Genetic Predisposition to Disease; Humans; Infant; Infusions, Intra-Arterial; Japan; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy, Adjuvant; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Risk Factors; Survivors | 2015 |
Risk-Based Therapy for Localized Osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Femoral Neoplasms; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Stem Cell Transplantation; Treatment Outcome | 2016 |
Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Doxorubicin; Humans; Hydrogels; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Xenograft Model Antitumor Assays | 2015 |
Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma.
Topics: Adult; Antimetabolites, Antineoplastic; Attention; Bone Neoplasms; Case-Control Studies; Cognition; Cognition Disorders; Cross-Sectional Studies; Emotions; Executive Function; Female; Humans; Male; Memory; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Osteosarcoma; Quality of Life; Risk Assessment; Risk Factors; Survivors; Time Factors; Treatment Outcome; United States | 2016 |
For Patients With Cancer, Cure Is Not Enough.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cognition; Cognition Disorders; Female; Hospitalization; Humans; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Osteosarcoma; Survivors | 2016 |
Krüppel-like factor 4 promotes high-mobility group box 1-induced chemotherapy resistance in osteosarcoma cells.
Topics: Antineoplastic Agents; Binding Sites; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Methotrexate; Osteosarcoma; Promoter Regions, Genetic; Protein Binding; Transcription, Genetic | 2016 |
Singapore Cancer Network (SCAN) Guidelines for the Initial Evaluation, Diagnosis, and Management of Extremity Soft Tissue Sarcoma and Osteosarcoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease Management; Doxorubicin; Extremities; Humans; Ifosfamide; Magnetic Resonance Imaging; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiotherapy; Radiotherapy, Adjuvant; Sarcoma; Singapore; Soft Tissue Neoplasms; Surgical Procedures, Operative; Tomography, X-Ray Computed | 2015 |
Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cytostatic Agents; Drug Screening Assays, Antitumor; Drug Synergism; Energy Metabolism; Enzyme Induction; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lactates; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Molecular Targeted Therapy; Neoplasm Proteins; Osteosarcoma; Ribonucleotides; RNA Interference; Transcription Factors | 2016 |
Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Deoxycytidine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; HEK293 Cells; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Sirolimus | 2016 |
Anti-VEGF-related thrombotic microangiopathy in a child presenting with nephrotic syndrome.
Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Male; Methotrexate; Nephrotic Syndrome; Niacinamide; Osteosarcoma; Phenylurea Compounds; Proteinuria; Remission, Spontaneous; Sorafenib; Thrombotic Microangiopathies; Vascular Endothelial Growth Factor A; Withholding Treatment | 2016 |
Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma.
Topics: Biopsy; Cisplatin; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; Osteosarcoma; Prognosis; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3 | 2016 |
Analytical interference in the therapeutic drug monitoring of methotrexate.
Topics: Adolescent; Bone Neoplasms; Contraindications; Cross Reactions; Drug Monitoring; Drug Substitution; Fluorescence Polarization Immunoassay; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma | 2016 |
Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Methotrexate; Osteosarcoma; Phosphoproteins; Protein Serine-Threonine Kinases; Signal Transduction; Transcription Factors; YAP-Signaling Proteins | 2016 |
Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Case-Control Studies; Child; Cisplatin; Cohort Studies; Disease-Free Survival; Doxorubicin; Female; gamma-Glutamyl Hydrolase; Genotype; Humans; Ifosfamide; Italy; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Protein 2; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Polymorphism, Genetic; Treatment Outcome; Young Adult | 2016 |
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Bayes Theorem; Bone Neoplasms; Chi-Square Distribution; Child; Female; gamma-Glutamyl Hydrolase; Genotype; Half-Life; Humans; Male; Metabolic Clearance Rate; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Odds Ratio; Osteosarcoma; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Risk Factors; Treatment Outcome | 2017 |
Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracorporeal Shockwave Therapy; Fluoresceins; Humans; Methotrexate; Osteosarcoma; Receptors, Purinergic P2X7 | 2016 |
Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients.
Topics: Adolescent; Adult; Age Factors; Child; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Sex Factors; Treatment Outcome; Young Adult | 2016 |
Simultaneous reconstruction of the bone and vessels for complex femoral defect.
Topics: Antineoplastic Agents; Autografts; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Femur; Fibula; Humans; Limb Salvage; Magnetic Resonance Imaging; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Saphenous Vein; Surgical Flaps; Transplantation, Autologous | 2016 |
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Limb Salvage; Methotrexate; Neoplasms, Second Primary; Oncogene Proteins, Fusion; Osteosarcoma; Proto-Oncogene Protein c-fli-1; Remission Induction; RNA-Binding Protein EWS; Sarcoma, Ewing; Vincristine | 2017 |
In vivo pharmacological evaluation and efficacy study of methotrexate-encapsulated polymer-coated layered double hydroxide nanoparticles for possible application in the treatment of osteosarcoma.
Topics: Aluminum; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxides; Kidney; Lactic Acid; Liver; Magnesium; Male; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Osteosarcoma; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tumor Burden | 2017 |
ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
Topics: Adenosine; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Osteosarcoma; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Survival Rate; Tetrahydrofolate Dehydrogenase | 2017 |
High-dose methotrexate in adults with osteosarcoma: a population pharmacokinetics study and validation of a new limited sampling strategy.
Topics: Adolescent; Adult; Alanine Transaminase; Antimetabolites, Antineoplastic; Bayes Theorem; Body Surface Area; Cost-Benefit Analysis; Creatinine; Drug Monitoring; Female; Forecasting; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Models, Biological; Osteosarcoma; Retrospective Studies; Time Factors | 2008 |
Osteosarcoma: the same old drugs or more?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Randomized Controlled Trials as Topic | 2008 |
COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclooxygenase 2; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasm Recurrence, Local; Osteosarcoma; Pneumonectomy; Prognosis; Retrospective Studies; Salvage Therapy; Survival Analysis | 2008 |
High-dose methotrexate in osteosarcoma: let the questions surcease--time for final acceptance.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Cycle; Child; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Lung Neoplasms; Methotrexate; Oliguria; Osteosarcoma; Prognosis | 2008 |
Management and successful desensitization in methotrexate-induced anaphylaxis.
Topics: Anaphylaxis; Child; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Methotrexate; Osteosarcoma | 2009 |
Neoadjuvant chemotherapy with high-dose methotrexate in osteosarcoma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Drug Administration Schedule; History, 20th Century; Humans; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome | 2008 |
Population pharmacokinetics of high-dose methotrexate after intravenous administration in pediatric patients with osteosarcoma.
Topics: Adolescent; Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Fluorescence Polarization Immunoassay; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Models, Statistical; Osteosarcoma; Reproducibility of Results | 2009 |
Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Comparative Genomic Hybridization; Doxorubicin; Drug Resistance, Neoplasm; Gene Amplification; Gene Dosage; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, Neoplasm; Histone-Lysine N-Methyltransferase; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Myeloid-Lymphoid Leukemia Protein; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Polymerase Chain Reaction; Reproducibility of Results; Tetrahydrofolate Dehydrogenase | 2009 |
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Drug Monitoring; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 2008 |
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Case-Control Studies; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gastrointestinal Diseases; Genotype; Hematologic Diseases; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolate Dehydrogenase | 2009 |
Epithelioid osteosarcoma of the jaw.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Doxorubicin; Epithelioid Cells; Female; Humans; Ifosfamide; Jaw Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome | 2009 |
Treatment of non-metastatic high-grade osteosarcoma (study of 30 cases treated with Scandinavian osteosarcoma protocol XIV and surgery).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Young Adult | 2008 |
High-dose methotrexate: the rationale...
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Delayed renal excretion of methotrexate after a severe anaphylactic reaction to methotrexate in a child with osteosarcoma.
Topics: Adolescent; Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Methotrexate; Osteosarcoma; Severity of Illness Index | 2009 |
Pulmonary toxocariasis masquerading as metastatic tumor nodules in a child with osteosarcoma.
Topics: Adolescent; Animals; Antibodies, Helminth; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cattle; Cattle Diseases; Cisplatin; Diagnosis, Differential; Doxorubicin; Food Parasitology; Humans; Humerus; Immunoglobulin G; Larva Migrans, Visceral; Liver; Lung Diseases, Parasitic; Lung Neoplasms; Male; Meat; Methotrexate; Osteosarcoma; Pulmonary Eosinophilia; Toxocariasis | 2009 |
An osteoporotic hip fracture in a 14-year-old girl undergoing chemotherapy and operated for knee osteosarcoma.
Topics: Adolescent; Antineoplastic Agents; Arthroplasty, Replacement, Knee; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Femur; Fracture Fixation, Internal; Hip Fractures; Humans; Ifosfamide; Immobilization; Magnetic Resonance Imaging; Methotrexate; Osteoporosis; Osteosarcoma; Postoperative Care; Radiography | 2009 |
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; HCT116 Cells; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Transfection; Tumor Cells, Cultured; Up-Regulation | 2009 |
Glucarpidase rescue in a patient with high-dose methotrexate-induced nephrotoxicity.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Drugs, Investigational; Enzyme Therapy; Female; gamma-Glutamyl Hydrolase; Humans; Jordan; Leucovorin; Mandibular Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome; Vitamin B Complex | 2011 |
Levoleucovorin.
Topics: Antineoplastic Agents; Cytoprotection; Humans; Leucovorin; Methotrexate; Osteosarcoma; Vitamin B Complex | 2008 |
High-dose methotrexate is effective in osteosarcoma so what is the problem?
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Treatment Outcome | 2009 |
Treatment of methotrexate intoxication with various modalities of continuous extracorporeal therapy and glucarpidase.
Topics: Adolescent; Antimetabolites, Antineoplastic; Compassionate Use Trials; Drugs, Investigational; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma; Renal Dialysis; Treatment Outcome | 2010 |
Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Biomarkers; Bone Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Methotrexate; Neoadjuvant Therapy; Neovascularization, Pathologic; Osteosarcoma; Platelet Endothelial Cell Adhesion Molecule-1; Predictive Value of Tests; Prognosis; Retrospective Studies; Vascular Endothelial Growth Factor A; Young Adult | 2010 |
Severe intoxication with methotrexate possibly associated with concomitant use of proton pump inhibitors.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bone Neoplasms; Child; Child, Preschool; Drug Interactions; gamma-Glutamyl Hydrolase; Humans; Lymphoma; Methotrexate; Middle Aged; Neuroblastoma; Osteosarcoma; Proton Pump Inhibitors; Retrospective Studies; Young Adult | 2010 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases | 2010 |
The establishment and characterization of adriamycin-resistant cell lines derived from Saos-2.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Inhibitory Concentration 50; Methotrexate; Osteosarcoma; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2010 |
Anaphylactoid reaction to high-dose methotrexate and successful desensitization.
Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Desensitization, Immunologic; Female; Humans; Methotrexate; Osteosarcoma; Tibia | 2010 |
Moyamoya in a child treated with interferon for recurrent osteosarcoma.
Topics: Antineoplastic Agents; Bone Neoplasms; Carotid Artery Diseases; Cerebral Arterial Diseases; Cerebral Infarction; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Interferon-alpha; Lung Neoplasms; Magnetic Resonance Angiography; Methotrexate; Moyamoya Disease; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Thyroiditis, Autoimmune | 2010 |
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Survival Rate; Tissue Distribution; Treatment Outcome; Young Adult | 2010 |
Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; IMP Dehydrogenase; Inhibitory Concentration 50; Methotrexate; Mycophenolic Acid; Osteosarcoma | 2010 |
Reduced methotrexate clearance and renal impairment in a boy with osteosarcoma and earlier undetected autosomal dominant polycystic kidney disease (ADPKD).
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Incidental Findings; Kidney; Male; Methotrexate; Osteosarcoma; Polycystic Kidney, Autosomal Dominant | 2010 |
Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective.
Topics: Adolescent; Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Cost-Benefit Analysis; Costs and Cost Analysis; Female; Home Infusion Therapy; Hospital Charges; Humans; Infusions, Intravenous; Leucovorin; Male; Medically Underserved Area; Methotrexate; Osteosarcoma; Urban Population; Young Adult | 2010 |
Outpatient high-dose methotrexate: proceed with extreme caution, if at all.
Topics: Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Methotrexate; Osteosarcoma | 2010 |
Low-dose carboxypeptidase-G2 for methotrexate toxicity in a child.
Topics: Adolescent; gamma-Glutamyl Hydrolase; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma | 2010 |
Skeletal imaging effects of pamidronate therapy in osteosarcoma patients.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Diphosphonates; Doxorubicin; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Pamidronate; Positron-Emission Tomography; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
Difficulty measuring methotrexate in a patient with high-dose methotrexate-induced nephrotoxicity.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma | 2010 |
Commentary.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma | 2010 |
Commentary.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bias; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma | 2010 |
[Bufalin induces apoptosis in osteosarcoma U-2OS and U-2OS methotrexate 300-resistant cell lines in vitro].
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Bufanolides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Tetrahydrofolate Dehydrogenase; Tumor Suppressor Protein p53 | 2010 |
Tumor volume increase during preoperative chemotherapy as a novel predictor of local recurrence in extremity osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Preoperative Care; Survival Rate; Treatment Outcome; Tumor Burden; Young Adult | 2011 |
Magnetic resonance imaging is appropriate for determining the osteotomy plane for appendicular osteosarcoma after neoadjuvant chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Epirubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Osteotomy; Preoperative Care; Prognosis; Prospective Studies; Surgery, Computer-Assisted; Survival Rate; Young Adult | 2012 |
Long-term survivals of stage IIb osteosarcoma: a 20-year experience in a single institution.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Infant; Kaplan-Meier Estimate; Leucovorin; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Vincristine; Young Adult | 2011 |
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Female; Finland; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Norway; Osteosarcoma; Sweden; Treatment Outcome; Young Adult | 2011 |
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Immunoenzyme Techniques; Methotrexate; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Osteosarcoma; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Triterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
Intracellular drug delivery of layered double hydroxide nanoparticles.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Humans; Hydroxides; Methotrexate; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Nanotechnology; Osteosarcoma; Particle Size | 2011 |
Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Membrane Potential, Mitochondrial; Methotrexate; Mitochondria; Osteosarcoma; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quercetin | 2011 |
Enrichment of osteosarcoma stem cells by chemotherapy.
Topics: Animals; Antigens, Surface; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Osteosarcoma; Phenotype; Proto-Oncogene Proteins c-kit | 2011 |
High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; Sex Factors; Treatment Outcome; Young Adult | 2012 |
Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Methotrexate; Osteosarcoma; RNA, Small Interfering | 2011 |
Clinical analysis of Chinese limb osteosarcoma patients treated by two combinations of methotrexate, cisplatin, doxorubicin and ifosfamide.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; China; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Retrospective Studies; Young Adult | 2011 |
The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Bone Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2011 |
A population pharmacokinetic/pharmacodynamic model of methotrexate and mucositis scores in osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Drug Monitoring; Female; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Mucositis; Osteosarcoma; Prospective Studies; Severity of Illness Index; Young Adult | 2011 |
Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Male; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Osteosarcoma; Receptor, ErbB-2; T-Lymphocytes; Xenograft Model Antitumor Assays | 2012 |
Extraskeletal osteosarcoma of the breast in an adolescent girl.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Chondroblastoma; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Methotrexate; Neoplasm Grading; Osteosarcoma; Treatment Outcome | 2012 |
Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Cyclohexanones; Doxorubicin; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Mitotic Index; NF-kappa B; Osteosarcoma; Protein Transport | 2012 |
Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Doxorubicin; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma | 2012 |
Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature.
Topics: Adult; Anti-Ulcer Agents; Drug Interactions; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Omeprazole; Osteosarcoma; Risk | 2012 |
Ifosfamide in the neoadjuvant treatment of osteogenic sarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma | 2012 |
Bullous variant of acral erythema in a child after high-dose methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Hand-Foot Syndrome; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Vitamin B Complex | 2012 |
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Bone Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Liver; Methotrexate; Osteosarcoma; Retrospective Studies; Treatment Outcome | 2012 |
Clinical monitoring in a patient with Friedreich ataxia and osteogenic sarcoma.
Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Neoplasms; Cisplatin; Cohort Studies; Doxorubicin; Female; Frataxin; Friedreich Ataxia; Humans; Immunosuppressive Agents; Iron-Binding Proteins; Male; Methotrexate; Osteosarcoma; Time Factors; Young Adult | 2012 |
[Organ-preserving interventions in combined therapy of children and adolescents with osteosarcoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Bone Transplantation; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Cohort Studies; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Neoadjuvant Therapy; Orthopedic Procedures; Osteosarcoma; Transplantation, Autologous; Treatment Outcome | 2012 |
Relationship between antimetabolite toxicity and pharmacogenetics in Turkish cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alleles; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); DNA; DNA-Binding Proteins; Drug Eruptions; Female; Fluorouracil; Gastrointestinal Neoplasms; Gene Frequency; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minisatellite Repeats; Mucositis; Osteosarcoma; Polymorphism, Genetic; Thymidylate Synthase; Turkey; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein; Young Adult | 2012 |
Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Density; Bone Neoplasms; Child; Female; Humans; Male; Methotrexate; Osteoporosis; Osteosarcoma; Retrospective Studies; Time Factors; Young Adult | 2012 |
Invariant NKT cells increase drug-induced osteosarcoma cell death.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cells, Cultured; Cisplatin; Doxorubicin; Humans; Immunotherapy, Adoptive; Methotrexate; Natural Killer T-Cells; Osteosarcoma | 2012 |
Preparation and antitumor activity of a polymeric derivative of methotrexate.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Humans; Methotrexate; Osteosarcoma; Peptides; Polymers | 2012 |
Analysis of prognostic factors in 333 Chinese patients with high-grade osteosarcoma treated by multidisciplinary combined therapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Limb Salvage; Male; Methotrexate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Young Adult | 2013 |
Targeting hedgehog-GLI-2 pathway in osteosarcoma.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Genetic Therapy; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Methotrexate; Nuclear Proteins; Osteoblasts; Osteosarcoma; RNA, Small Interfering; Zinc Finger Protein Gli2 | 2013 |
Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cyclophosphamide; Dactinomycin; DNA-Binding Proteins; DNA, Neoplasm; Doxorubicin; Endonucleases; Female; Glutathione S-Transferase pi; Humans; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prognosis; Survival Rate; Vincristine; Xeroderma Pigmentosum Group D Protein; Young Adult | 2012 |
Osteosarcoma of the pelvis: a monoinstitutional experience in patients younger than 41 years.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Osteosarcoma; Pelvic Bones; Prospective Studies; Radiography; Remission Induction; Treatment Outcome | 2012 |
Pharmacokinetic interaction between high-dose methotrexate and oxacillin.
Topics: Adolescent; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Drug Interactions; Fatal Outcome; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Oxacillin; Staphylococcal Skin Infections | 2002 |
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Media; Cytarabine; Dialysis; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Fetal Blood; Humans; Hypoxanthine; Methotrexate; Neoplasm Proteins; Nucleotides; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Thymidine; Tumor Cells, Cultured; Vidarabine | 2002 |
Effective removal of methotrexate by high-flux hemodialysis.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Fluorescence Polarization Immunoassay; gamma-Glutamyl Hydrolase; Half-Life; Humans; Hypokalemia; Hypophosphatemia; Infusions, Intravenous; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Renal Dialysis; Rhabdomyosarcoma | 2002 |
Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome | 2002 |
A pilot study of short-course intensive multiagent chemotherapy in metastatic and axial skeletal osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bone Neoplasms; Child; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Pilot Projects; Prognosis; Risk Assessment; Sampling Studies; Survival Analysis; Treatment Outcome | 2002 |
Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy.
Topics: Adult; Antidotes; Female; gamma-Glutamyl Hydrolase; Humans; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; Treatment Outcome | 2002 |
Successful desensitization to high-dose methotrexate after systemic anaphylaxis.
Topics: Adult; Anaphylaxis; Bone Neoplasms; Desensitization, Immunologic; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Male; Methotrexate; Osteosarcoma | 2003 |
Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Arm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Immunohistochemistry; Leg; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Risk Factors | 2003 |
Use of plasma exchange in methotrexate removal in a patient with osteosarcoma and acute renal insufficiency.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Diuresis; Female; Femoral Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma; Plasma Exchange; Thoracic Neoplasms | 2003 |
Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Follow-Up Studies; Humans; Ifosfamide; Incidence; Infant, Newborn; Italy; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Oligospermia; Osteosarcoma; Puberty; Semen Preservation; Sperm Count; Surveys and Questionnaires | 2003 |
Acute hypokalemic tetraparesis induced by intravenous methotrexate.
Topics: Adult; Antimetabolites, Antineoplastic; Humans; Hypokalemia; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Paresis | 2003 |
Identification of drug-regulated genes in osteosarcoma cells.
Topics: Actinin; Antineoplastic Agents; Apoptosis; Blotting, Northern; Bone Neoplasms; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Ferritins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; IMP Dehydrogenase; Isoenzymes; Methotrexate; Neoplasm Proteins; Nucleic Acid Hybridization; Osteosarcoma; Prohibitins; Protein Biosynthesis; Proteins; Repressor Proteins; rhoA GTP-Binding Protein; Ribonucleotide Reductases; Subtraction Technique; Transfection; Tumor Cells, Cultured | 2003 |
Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Europe; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Proportional Hazards Models; Survival Analysis; Treatment Outcome | 2003 |
Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Patient Compliance; Prognosis; Salvage Therapy; Survival Analysis | 2003 |
Long-term survival in osteosarcoma patients following retinoblastoma using doxorubicin, cisplatin, and methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Cisplatin; Doxorubicin; Humans; Humerus; Infant; Male; Methotrexate; Neoplasms, Second Primary; Osteosarcoma; Retinal Neoplasms; Retinoblastoma; Survivors; Tibia | 2003 |
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Topics: Adolescent; Adult; Aged; Carrier Proteins; Cell Cycle Proteins; Child; Child, Preschool; DNA; DNA-Binding Proteins; Drug Resistance, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Female; Humans; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription Factors | 2003 |
OSTEOGENIC SARCOMA IN CHILDHOOD.
Topics: Adolescent; Bone Neoplasms; Child; Humans; Infant; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Osteosarcoma; Radiography; Sarcoma; Surgical Procedures, Operative | 1963 |
DETERMINATIONS OF THE LEVELS OF SERUM FOLATE IN PATIENTS WITH CARCINOMA OF THE HEAD AND NECK TREATED WITH METHOTREXATE.
Topics: Blood Chemical Analysis; Carcinoma, Squamous Cell; Folic Acid; Humans; Methotrexate; Nasopharyngeal Neoplasms; Neoplasms; Nose Neoplasms; Osteosarcoma; Pathology; Pharmacology; Pharyngeal Neoplasms; Sarcoma; Tongue Neoplasms | 1964 |
OSTEOGENIC SARCOMA OF THE MANDIBLE. REPORT OF CASE TREATED BY RADIATION AND CHEMOTHERAPY.
Topics: Bone Neoplasms; Cobalt Isotopes; Dactinomycin; Drug Therapy; Humans; Mandible; Mandibular Neoplasms; Melphalan; Methotrexate; Neoplasms; Osteomyelitis; Osteosarcoma; Pathology; Radiography; Radium; Sarcoma | 1964 |
Progression of osteosarcoma after high-dose methotrexate: over-rescue by folinic acid.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Femur; Humans; Ifosfamide; Leucovorin; Methotrexate; Osteosarcoma | 2003 |
Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.
Topics: Antineoplastic Agents; Bone Neoplasms; Chromosome Aberrations; Chromosomes, Human; Drug Resistance, Neoplasm; Humans; Karyotyping; Membrane Transport Proteins; Methotrexate; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Ploidies; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2003 |
Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity.
Topics: Actins; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Carrier Proteins; Child; Drug Resistance, Neoplasm; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 2003 |
Preoperative therapy versus immediate surgery in nonmetastatic osteosarcoma.
Topics: Amputation, Surgical; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma | 2003 |
Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Gene Amplification; Gene Deletion; Gene Expression Regulation, Neoplastic; Hexosyltransferases; Humans; In Vitro Techniques; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Reduced Folate Carrier Protein; Retinoblastoma Protein; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2004 |
Methotrexate pharmacokinetics and survival in osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Survival Rate | 2004 |
Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Separation; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Immunohistochemistry; Inhibitory Concentration 50; Interleukin-12; Membrane Glycoproteins; Methotrexate; Osteosarcoma; RNA, Messenger; Time Factors; Transfection; Up-Regulation | 2004 |
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Carrier Proteins; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 2004 |
Layered double hydroxide as an efficient drug reservoir for folate derivatives.
Topics: Absorption; Antineoplastic Agents; Biocompatible Materials; Cell Division; Cell Line, Tumor; Drug Delivery Systems; Drug Evaluation; Drug Stability; Fibroblasts; Folic Acid; Humans; Hydroxides; Leucovorin; Macromolecular Substances; Materials Testing; Methotrexate; Molecular Conformation; Osteosarcoma; Pharmaceutical Vehicles | 2004 |
Optimal management of methotrexate intoxication in a child with osteosarcoma.
Topics: Acute Kidney Injury; Adolescent; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Humans; Male; Methotrexate; Mouth Mucosa; Osteosarcoma; Stomatitis | 2004 |
Low-voltage electrochemotherapy with low-dose methotrexate enhances survival in mice with osteosarcoma.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Electroporation; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Osteosarcoma; Survival Rate | 2004 |
[Goal and results of the COSS study].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Germany; Hand; Humans; Ifosfamide; Methotrexate; Multicenter Studies as Topic; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Patient Care Team; Prognosis; Survival Rate | 2004 |
Tumor excision and reconstruction of the upper cervical spine: a multidisciplinary approach.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Axis, Cervical Vertebra; Bone Transplantation; Cervical Atlas; Chemotherapy, Adjuvant; Chondrosarcoma; Chordoma; Combined Modality Therapy; Cranial Fossa, Posterior; Etoposide; Fatal Outcome; Female; Femoral Neoplasms; Humans; Ifosfamide; Interdisciplinary Communication; Internal Fixators; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Palliative Care; Patient Care Team; Proton Therapy; Remission Induction; Skull Base Neoplasms; Spinal Fusion; Spinal Neoplasms; Surgical Flaps | 2004 |
Low tumor cell density environment yields survival advantage of tumor cells exposed to MTX in vitro.
Topics: Adaptation, Physiological; Antimetabolites, Antineoplastic; Cell Count; Cell Survival; Drug Resistance, Neoplasm; HT29 Cells; Humans; Methotrexate; Neoplasms; Osteosarcoma | 2005 |
Long-term survival in high-grade axial osteosarcoma with bone and lung metastases treated with chemotherapy only.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child, Preschool; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Ifosfamide; Lumbar Vertebrae; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Thoracic Vertebrae; Time Factors; Tomography, X-Ray Computed | 2005 |
Sarcomas of the head and neck. Results from the treatment of 25 patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma; Radiotherapy, Adjuvant; Retrospective Studies; Sarcoma; Surgical Procedures, Operative; Treatment Outcome | 2005 |
Methotrexate levels and outcome in osteosarcoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Male; Methotrexate; Necrosis; Osteosarcoma; Prognosis; Prospective Studies; Treatment Outcome | 2005 |
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mice; Mice, SCID; Necrosis; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Prognosis; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Survival Rate; Transplantation, Heterologous; Treatment Outcome | 2005 |
Quantitative thallium-201 scintigraphy in childhood osteosarcoma: Comparison with technetuim-99m MDP and magnetic resonance imaging in the evaluation of chemotherapeutic response.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Diagnostic Imaging; Doxorubicin; Drug Monitoring; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Radionuclide Imaging; Remission Induction; Technetium Tc 99m Medronate; Thallium Radioisotopes | 2005 |
Acral erythema caused by high-dose methotrexate therapy in patients with osteogenic sarcoma.
Topics: Adolescent; Adult; Erythema; Female; Foot; Hand; Humans; Methotrexate; Osteosarcoma; Pain | 2005 |
Methotrexate-induced bullous acral erythema in a child.
Topics: Antimetabolites, Antineoplastic; Child; Erythema; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Skin Diseases, Vesiculobullous | 2005 |
The role of preoperative radiotherapy in nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery.
Topics: Adolescent; Adult; Aged; Amputation, Surgical; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Epirubicin; Extremities; Humans; Ifosfamide; Limb Salvage; Male; Mesna; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Radiotherapy Dosage; Retrospective Studies; Survival Rate | 2005 |
Prospective evaluation of renal function in pediatric and adult patients treated with high-dose ifosfamide, cisplatin and high-dose methotrexate.
Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney Function Tests; Male; Methotrexate; Osteosarcoma; Prospective Studies | 2005 |
High dose methotrexate in adult patients with osteosarcoma: clinical and pharmacokinetic results.
Topics: Adolescent; Adult; Area Under Curve; Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Survival Rate | 2005 |
The classic: recent advances in chemotherapy of metastatic osteogenic sarcoma. 1972.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; History, 20th Century; Humans; Leucovorin; Methotrexate; Orthopedics; Osteosarcoma; Vitamin B Complex | 2005 |
Acute cardiac toxicity associated with high-dose intravenous methotrexate therapy: case report and review of the literature.
Topics: Adult; Antimetabolites, Antineoplastic; Bradycardia; Electrocardiography; Fatal Outcome; Female; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Osteosarcoma; Spinal Neoplasms; Tachycardia, Ventricular; Vitamin B Complex | 2005 |
Expression profiles of osteosarcoma that can predict response to chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Nuclear Proteins; Osteosarcoma; Predictive Value of Tests; Prognosis; Razoxane; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Twist-Related Protein 1 | 2005 |
Dose intensity of chemotherapy for osteosarcoma and outcome in the Cooperative Osteosarcoma Study Group (COSS) trials.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Ifosfamide; Infant; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Proportional Hazards Models; Retrospective Studies; Survival Analysis | 2006 |
A successful case of allogeneic bone marrow transplantation for osteosarcoma with multiple metastases of lung and bone.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Femoral Neoplasms; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission Induction; Transplantation, Homologous; Treatment Outcome | 2006 |
Fas expression in lung metastasis from osteosarcoma patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Dendritic Cells; Doxorubicin; fas Receptor; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Neoplasm Staging; Osteosarcoma; Paraffin Embedding; Preoperative Care | 2005 |
High energy shock waves enhance the cytotoxic effect of doxorubicin and methotrexate to human osteosarcoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; High-Energy Shock Waves; Humans; Methotrexate; Osteosarcoma | 2006 |
Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis.
Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Tocopherols; Vitamin E | 2006 |
Low-dose methotrexate inhibits lung metastasis and lengthens survival in rat osteosarcoma.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Rats; Rats, Inbred F344; Survival Analysis | 2005 |
No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Preoperative Care | 2006 |
Cisplatin-induced hypomagnesemia and cardiac dysrhythmia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Gastroenteritis; Heart Arrest; Humans; Magnesium; Methotrexate; Osteosarcoma; Water-Electrolyte Imbalance | 2007 |
Clearance of methotrexate by means of hemofiltration in a patient with osteosarcoma.
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; gamma-Glutamyl Hydrolase; Hemofiltration; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Tibia | 2006 |
Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.
Topics: Adolescent; Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Monitoring; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma | 2007 |
Neoadjuvant chemotherapy for radioinduced osteosarcoma of the extremity: The Rizzoli experience in 20 cases.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Radiation-Induced; Osteosarcoma; Retrospective Studies | 2007 |
Osteosarcoma metastatic to the kidney and iatrogenic hemorrhage.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Bone Neoplasms; Calcinosis; Camptothecin; Child; Combined Modality Therapy; Doxorubicin; Fatal Outcome; Female; Hematuria; Hemorrhage; Humans; Iatrogenic Disease; Ilium; Irinotecan; Kidney Neoplasms; Lung Neoplasms; Methotrexate; Osteosarcoma; Radiography; Tibia; Ultrasonography, Interventional | 2008 |
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Bone Neoplasms; Carcinoma, Squamous Cell; Caspase 3; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mutation; Osteosarcoma; RNA, Small Interfering; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Limb salvage surgery for osteosarcoma: effective low-cost treatment.
Topics: Adolescent; Adult; Antineoplastic Agents; Arm Bones; Bone Neoplasms; Child; Cohort Studies; Disease-Free Survival; Female; Humans; India; Internal Fixators; Leg Bones; Limb Salvage; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Treatment Outcome | 2007 |
Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bufanolides; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Tetrahydrofolate Dehydrogenase | 2007 |
Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma.
Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cisplatin; Doxorubicin; Humans; Immunohistochemistry; Methotrexate; Osteoblasts; Osteosarcoma; RNA, Messenger; Syndecan-2 | 2007 |
Chemotherapy for osteosarcoma without high-dose methotrexate: another piece in the puzzle.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate | 2007 |
Chemotherapy for osteosarcoma without high-dose methotrexate: a 12-year follow-up on 53 patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Limb Salvage; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Survival Rate | 2007 |
The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Osteosarcoma; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolates; Xenograft Model Antitumor Assays | 2007 |
Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Folic Acid Antagonists; Glutamates; Guanine; Humans; Immunoblotting; Methotrexate; Osteosarcoma; Pemetrexed; Thymidylate Synthase | 2008 |
Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Contraindications; Cyclophosphamide; Dactinomycin; Drug Administration Schedule; Extremities; Female; Humans; Limb Salvage; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Treatment Outcome | 2007 |
Prognosis of radiation-induced bone sarcoma is similar to primary osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Humans; Ifosfamide; Methotrexate; Middle Aged; Neoplasms, Radiation-Induced; Osteosarcoma; Radionuclide Imaging; Sarcoma; Survival Rate | 2007 |
Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer.
Topics: Acute Disease; Adolescent; Aminophylline; Antimetabolites, Antineoplastic; Bone Neoplasms; Brain; Child; Diffusion Magnetic Resonance Imaging; Female; Histiocytoma, Malignant Fibrous; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Metabolic Clearance Rate; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2008 |
Relative tumor burden predicts metastasis-free survival in pediatric osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Prognosis; Radionuclide Imaging; Retrospective Studies | 2008 |
Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cohort Studies; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Medical Records; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Radiotherapy Dosage; Retrospective Studies; Risk Factors; Survival Rate | 2008 |
The Memorial Sloan Kettering Cancer Center experience with outpatient administration of high dose methotrexate with leucovorin rescue.
Topics: Adolescent; Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Drug Monitoring; Female; Humans; Infusions, Intravenous; Kidney; Leucovorin; Male; Methotrexate; Neutropenia; Osteosarcoma | 2008 |
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases.
Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Collagen; Drug Combinations; Extracellular Matrix; Formazans; Humans; Inhibitory Concentration 50; Karyotyping; Laminin; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Metastasis; Osteosarcoma; Proteoglycans; Tetrazolium Salts; Xenograft Model Antitumor Assays | 2008 |
Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression; Genes, myc; Humans; Immunohistochemistry; Methotrexate; Oligonucleotides, Antisense; Osteosarcoma; Proto-Oncogene Proteins c-myc; Tetrahydrofolate Dehydrogenase | 2008 |
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting | 2008 |
Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study.
Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Mandibular Neoplasms; Maxillary Neoplasms; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Young Adult | 2008 |
Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Drug Therapy; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein; RNA, Messenger | 2008 |
[Initial chemotherapy and conservative surgery in the current treatment of osteosarcoma. Apropos of 24 cases].
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Male; Methods; Methotrexate; Osteosarcoma; Vincristine | 1984 |
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Resistance; Fluorouracil; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Lymphoma; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Osteosarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Succinate Dehydrogenase; Vincristine | 1984 |
[Dye concentration measurements for the determination of leakage during and following normothermic cytostatic perfusion in the treatment of tumors of the extremities].
Topics: Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Histiocytoma, Benign Fibrous; Humans; Indigo Carmine; Indoles; Male; Melanoma; Methotrexate; Osteosarcoma; Soft Tissue Neoplasms; Spectrophotometry; Vincristine | 1984 |
Numerical changes in the various peripheral white blood cells in children as a result of antineoplastic therapy.
Topics: Antineoplastic Agents; Basophils; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Eosinophils; Hodgkin Disease; Humans; Leukocyte Count; Leukocytes; Lymphocytes; Methotrexate; Monocytes; Neuroblastoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Time Factors; Vincristine; Wilms Tumor | 1984 |
[Combination chemotherapy in osteogenic sarcoma: the Memorial Sloan-Kettering cancer center experience (author's transl)].
Topics: Adolescent; Adult; Bleomycin; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care | 1980 |
The combined effect of interferon and methotrexate on human osteosarcoma and lymphoma cell lines.
Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Humans; Interferons; Lymphoma; Methotrexate; Osteosarcoma | 1980 |
Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.
Topics: Antineoplastic Agents; Bleomycin; Bone Neoplasms; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Time Factors | 1982 |
Lymphocyte capping in muscular dystrophies.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Immunologic Capping; Infant; Interferons; Leukemia, Myeloid; Lymphocytes; Male; Methotrexate; Middle Aged; Muscular Dystrophies; Osteosarcoma; Subacute Sclerosing Panencephalitis | 1982 |
What has adjuvant chemotherapy of osteosarcoma achieved? Discussion paper.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma | 1983 |
Methotrexate and methotrexate polyglutamates in human sarcoma metastases after high-dose methotrexate therapy.
Topics: Biotransformation; Bone Neoplasms; Dose-Response Relationship, Drug; Humans; Leiomyosarcoma; Lung; Lung Neoplasms; Methotrexate; Osteosarcoma; Peptides; Polyglutamic Acid; Skin; Skin Neoplasms | 1983 |
Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue.
Topics: Chromatography, High Pressure Liquid; Humans; Leucovorin; Methotrexate; Osteosarcoma; Peptides; Polyglutamic Acid | 1984 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Ferrokinetics after high-dose methotrexate therapy.
Topics: Carcinoma, Small Cell; Dose-Response Relationship, Drug; Erythropoiesis; Humans; Iron; Kinetics; Lung Neoplasms; Methotrexate; Osteosarcoma; Soft Tissue Neoplasms | 1981 |
[Changes in the management of osteosarcomas of long bones in the Léon Bérard Center, in the last twenty years ].
Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Extremities; France; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma | 1982 |
[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics].
Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma; Sodium Bicarbonate | 1984 |
[In vitro cytotoxicity of methotrexate].
Topics: Animals; Cell Division; Cells, Cultured; Drug Evaluation, Preclinical; Leucovorin; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Time Factors | 1984 |
[Therapeutic response of various histological osteosarcoma subtypes to high-dose methotrexate treatment].
Topics: Adolescent; Adult; Bone Neoplasms; Female; Femoral Neoplasms; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Tibia | 1983 |
Local control of osteogenic sarcoma by radiation and chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Radiotherapy, High-Energy | 1984 |
Chemotherapy of sarcomas.
Topics: Doxorubicin; Humans; Methotrexate; Osteosarcoma; Sarcoma | 1983 |
[The Zurich experience with preoperative high-dose methotrexate in osteosarcomas].
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Staging; Osteosarcoma; Premedication; Prognosis | 1983 |
[The use of medium- and high-dose methotrexate in the management of malignant childhood diseases].
Topics: Adolescent; Antineoplastic Agents; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leukemia, Myeloid, Acute; Lymphoma; Male; Methotrexate; Osteosarcoma | 1983 |
Angiographic-pathologic comparison in osteosarcoma after presurgical chemotherapy.
Topics: Adolescent; Adult; Angiography; Bone Neoplasms; Child; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Male; Methotrexate; Osteosarcoma | 1983 |
Adjuvant chemotherapy for osteosarcoma at the Singapore General Hospital.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Singapore; Vincristine | 1983 |
[Comprehensive therapy of osteosarcoma using high doses of methotrexate--experience 1980-1983].
Topics: Adolescent; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma | 1983 |
[Evaluation of severe side effects of high-dose methotrexate in osteosarcoma].
Topics: Adolescent; Adult; Anaphylaxis; Bone Neoplasms; Child; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Nervous System Diseases; Osteosarcoma; Sensation; Vomiting | 1984 |
Osteogenic sarcoma: alterations in the pattern of pulmonary metastases with adjuvant chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors | 1983 |
Transient encephalopathy during the late course of treatment with high-dose methotrexate.
Topics: Bone Neoplasms; Brain Diseases; Child; Female; Humans; Humerus; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors; Tomography, X-Ray Computed | 1984 |
Antigenicity and drug susceptibility of human osteogenic sarcoma cells "escaping" a cytotoxic methotrexate-albumin-monoclonal antibody conjugate.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Cell Line; Drug Resistance; Humans; Methotrexate; Neoplastic Stem Cells; Osteosarcoma; Serum Albumin; Tumor Stem Cell Assay | 1984 |
Preoperative administration of high-dose methotrexate for osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Osteosarcoma | 1984 |
Osteogenic sarcoma of the fourth thoracic vertebra. Long-term survival by chemotherapy only.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Spinal Neoplasms; Thoracic Vertebrae; Vincristine | 1984 |
Potentiation of methotrexate toxicity by dipyridamole.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dipyridamole; DNA Replication; Drug Synergism; Female; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Osteosarcoma; Ovary | 1984 |
Experience in the preparation and experimental use of immunocytostatics.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Humans; Methotrexate; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Osteosarcoma; Sarcoma, Experimental; Transplantation, Heterologous; Vinblastine; Vindesine | 1984 |
Adjuvant chemotherapy in osteogenic sarcoma.
Topics: Combined Modality Therapy; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Research Design | 1984 |
[Treatment of osteosarcoma with pre- and postoperative chemotherapy and non-mutilating surgery].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Knee Joint; Knee Prosthesis; Male; Methods; Methotrexate; Osteosarcoma | 1984 |
Analysis of surface antigen expression per cell of human osteogenic sarcoma cells by fluorescence-labelled monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Cycle; Cells, Cultured; DNA, Neoplasm; Flow Cytometry; Fluorescence; Humans; Methotrexate; Mice; Osteosarcoma; RNA, Neoplasm | 1984 |
High-dose methotrexate for osteosarcoma: toxicity and clinical results.
Topics: Adolescent; Adult; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Mucous Membrane; Osteosarcoma | 1983 |
High dose systemic methotrexate-associated acute neurologic dysfunction.
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Female; Femoral Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 1983 |
Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care; Radiography; Time Factors | 1983 |
Treatment of primary osteosarcoma with intra-arterial and intravenous high-dose methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Leucovorin; Methotrexate; Osteosarcoma | 1983 |
Essential laboratory determinations for monitoring high-dose methotrexate treatment with citrovorum factor rescue.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Child; Half-Life; Humans; Kidney Function Tests; Leucovorin; Liver Function Tests; Methotrexate; Osteosarcoma | 1983 |
The inability of oral leucovorin to elevate CSF 5-methyl-tetrahydrofolate following high dose intravenous methotrexate therapy.
Topics: Adolescent; Adult; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Tetrahydrofolates | 1983 |
[EEG-slowing after high-dose Methotrexate with citrovorumfactor-rescue. A spectralanalytic study (author's transl)].
Topics: Adolescent; Adult; Cerebral Cortex; Child; Electroencephalography; Evoked Potentials; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1982 |
Multiple-drug chemotherapy for the primary treatment of osteosarcoma of the extremities.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Vincristine | 1980 |
Surgical adjuvant chemotherapy of metastatic murine osteosarcoma.
Topics: Amputation, Surgical; Animals; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Lung Neoplasms; Methotrexate; Mice; Osteosarcoma; Sarcoma, Experimental; Time Factors | 1980 |
Protein-methotrexate-IgG complexes in the serum of patients receiving high-dose antifolate therapy.
Topics: Antigen-Antibody Complex; Breast Neoplasms; Chromatography, Gel; Drug Administration Schedule; Humans; Hypersensitivity, Immediate; Immunization; Immunoglobulin G; Infusions, Parenteral; Methotrexate; Osteosarcoma; Protein Binding | 1980 |
Is amputation necessary for sarcomas? A seven-year experience with limb salvage.
Topics: Adolescent; Adult; Aged; Amputation, Surgical; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Sarcoma; Soft Tissue Neoplasms | 1980 |
Isolation of tumor cells from patients with osteosarcoma and analysis of their sensitivity to methotrexate.
Topics: Cell Separation; Cells, Cultured; Deoxyuridine; DNA; Drug Resistance; Humans; Hypoxanthines; Lung Neoplasms; Methotrexate; Osteosarcoma; Stimulation, Chemical; Thymidine | 1981 |
The effect of liposome (phospholipid vesicle) entrapment of actinomycin D and methotrexate on the in vivo treatment of sensitive and resistant solid murine tumours.
Topics: Animals; Dactinomycin; Dose-Response Relationship, Drug; Drug Resistance; Female; Liposomes; Methotrexate; Mice; Mice, Inbred AKR; Osteosarcoma; Sarcoma, Experimental; Tissue Distribution | 1981 |
[Results of Primary chemotherapy and Delayed Surgical Resection in Osteosarcoma (author's transl)].
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma | 1981 |
Planning discharge for a patient with osteogenic sarcoma.
Topics: Bone Neoplasms; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Patient Discharge | 1981 |
Adjuvant treatment of osteosarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; BCG Vaccine; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma | 1981 |
[Therapeutic results of patients with osteogenic sarcoma by the protocol COSS 77 (author's transl)].
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Vincristine | 1981 |
High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results.
Topics: Amputation, Surgical; Angiography; Bone Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Extremities; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors | 1981 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental | 1981 |
Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.
Topics: Adolescent; Adult; Bile; Bone Neoplasms; Charcoal; Chromatography, High Pressure Liquid; Gastric Juice; Half-Life; Humans; Infusions, Parenteral; Kinetics; Methotrexate; Middle Aged; Osteosarcoma | 1982 |
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytotoxicity, Immunologic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Lymphocyte Activation; Methotrexate; Neoplasms; Osteosarcoma; Pregnancy; Quinazolines; Sarcoma, Experimental | 1982 |
[Experience with high-dose methotrexate therapy for malignant solid tumors].
Topics: Adolescent; Adult; Brain Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Glioma; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pons | 1982 |
[A study on the treatment of pulmonary metastatic osteosarcoma].
Topics: Antineoplastic Agents; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Vincristine | 1982 |
Plasma methotrexate as determined by liquid chromatography, enzyme-inhibition assay, and radioimmunoassay after high-dose infusion.
Topics: Adolescent; Adult; Child; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme Inhibitors; Humans; Infusions, Parenteral; Leucovorin; Methotrexate; Osteosarcoma; Radioimmunoassay | 1980 |
High-dose methotrexate used alone and in combination for measurable primary or metastatic osteosarcoma.
Topics: Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1980 |
Vincristine in the etiology of toxicity of high-dose methotrexate therapy.
Topics: Adolescent; Dose-Response Relationship, Drug; Drug Combinations; Humans; Infusions, Parenteral; Intestinal Obstruction; Intestine, Large; Leucovorin; Male; Methotrexate; Osteosarcoma; Reflex, Stretch; Vincristine | 1980 |
[High-dose methotrexate with citrovorum factor rescue in osteogenic carcinoma].
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1980 |
Normal computed tomograms of the brain in osteosarcoma patients treated with high-dose methotrexate.
Topics: Adolescent; Adult; Brain; Child; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Time Factors; Tomography, X-Ray Computed | 1981 |
[Disturbances of coagulation following high-dosage methotrexate with citrovorum factor rescue in patients with osteogenous sarcoma. (author's transl)].
Topics: Aspartate Aminotransferases; Blood Coagulation Factors; Child; Disseminated Intravascular Coagulation; Female; Heparin; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1981 |
Evaluation of results of new treatments for osteosarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis | 1980 |
High-dose methotrexate with a safe rescue program.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Female; Humans; Leucovorin; Leukocyte Count; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma | 1981 |
[Risk analysis of the treatment of solid tumors with high dosage methotrexate: apropos of 154 cases].
Topics: Adolescent; Child; Child, Preschool; Humans; Kidney; Leucovorin; Lymphoma; Methotrexate; Osteosarcoma; Risk | 1981 |
High-dose methotrexate in osteogenic sarcoma.
Topics: Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Humans; Kinetics; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Vincristine | 1981 |
Prognostic factors in the response of primary osteogenic sarcoma to preoperative chemotherapy (high-dose methotrexate with citrovorum factor).
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies | 1981 |
Adjuvant chemotherapy for osteosarcoma: a decade of experience.
Topics: Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Probability; Time Factors; Vincristine | 1981 |
Adjuvant chemotherapy for primary osteogenic sarcoma.
Topics: Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Humans; Immunization; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma | 1981 |
Selected applications of methotrexate alone and in combination in osteosarcoma.
Topics: Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Vincristine | 1981 |
[H-MTX-CF treatment and osteogenic sarcoma (author's transl)].
Topics: Adolescent; Adult; Bone Neoplasms; Child; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1981 |
Improved three-year disease-free survival in osteogenic sarcoma.
Topics: Adolescent; Adult; Age Factors; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Sex Factors; Vincristine | 1982 |
Radiographic changes in primary osteogenic sarcoma following intensive chemotherapy. Radiological-pathological correlation in 63 patients.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Radiography | 1982 |
[Studies on the effect of high-dose methotrexate-citrovorum factor treatment for 89Sr induced osteosarcoma in mice (author's transl)].
Topics: Animals; Drug Therapy, Combination; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred Strains; Osteosarcoma; Sarcoma, Experimental; Strontium Radioisotopes | 1982 |
High-dose methotrexate and adriamycin in osteogenic sarcoma: the children's hospital of Philadelphia study.
Topics: Actuarial Analysis; Adolescent; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1982 |
Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".
Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1982 |
Chemotherapy for osteogenic sarcoma: an investigative method, not a recipe.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Economics; Femoral Neoplasms; Humans; Humerus; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Tibia | 1982 |
[New therapeutic results in osteosarcoma].
Topics: Amputation, Surgical; Bone Neoplasms; Female; Humans; Humerus; Leucovorin; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis | 1982 |
Treatment by amputation and chemotherapy.
Topics: Amputation, Surgical; BCG Vaccine; Bone Neoplasms; Doxorubicin; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1982 |
Chemotherapy in osteogenic sarcoma.
Topics: Bone Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Leucovorin; Melphalan; Methotrexate; Osteosarcoma; Vincristine | 1982 |
[Tissue concentration of methotrexate in osteosarcoma after high-dose infusion].
Topics: Adolescent; Adult; Animals; Bone Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Tissue Distribution | 1982 |
Adjuvant systemic therapy after ablative surgery for limb osteosarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Postoperative Care | 1982 |
Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT).
Topics: Adult; Aminopterin; Autoanalysis; Costs and Cost Analysis; Female; Humans; Immunoenzyme Techniques; Kinetics; Methotrexate; Neoplasms; Osteosarcoma | 1980 |
Cutaneous pathobiology mediated by chemotherapy.
Topics: Adolescent; Antineoplastic Agents; Autoradiography; Bone Neoplasms; Epidermis; Female; Humans; Methotrexate; Middle Aged; Osteosarcoma; Psoriasis; Purpura; Skin; Skin Diseases, Vesiculobullous | 1980 |
[Controlled ultra-high dosage methotrexate therapy in three patients with metastatic osteosarcoma (author's transl)].
Topics: Adolescent; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunoenzyme Techniques; Leucovorin; Male; Methotrexate; Osteosarcoma; Prognosis | 1981 |
Identification and quantitation of methotrexate and methotrexate metabolites in clinical high-dose therapy by high pressure liquid chromatography and field desorption mass spectrometry.
Topics: Adult; Chromatography, High Pressure Liquid; Folic Acid; Humans; Immunoenzyme Techniques; Male; Mass Spectrometry; Methotrexate; Osteosarcoma | 1982 |
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Division; Cell Line; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fibrosarcoma; Floxuridine; Humans; Liposarcoma; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Osteosarcoma; Recombinant Proteins; Retinoblastoma Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured | 1995 |
Osteosarcoma following radiation treatment for meningioma: report of a case and effective treatment with chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Cisplatin; Dactinomycin; Etoposide; Female; Gonadotropin-Releasing Hormone; Humans; Ifosfamide; Lung Neoplasms; Meningeal Neoplasms; Meningioma; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Osteosarcoma; Tamoxifen; Tomography, X-Ray Computed; Vincristine | 1994 |
Quantitative evaluation of thallium-201 uptake in predicting chemotherapeutic response of osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Prospective Studies; Radionuclide Imaging; Thallium Radioisotopes | 1995 |
A monocentric therapy study: an approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery.
Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Methotrexate; Middle Aged; Osteosarcoma; Pilot Projects; Remission Induction; Salvage Therapy; Treatment Outcome; Vincristine | 1993 |
Osteosarcoma: experience with the Rosen T10 protocol at RCH, Melbourne.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leucovorin; Life Tables; Male; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; Victoria; Vincristine | 1993 |
[Successful treatment with administration of systemic high dose methotrexate and intraarterial carboplatin for osteosarcoma of the skull: a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Combined Modality Therapy; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Remission Induction; Skull Neoplasms | 1995 |
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.
Topics: Adolescent; Bone Neoplasms; Dose-Response Relationship, Drug; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma | 1994 |
Osteosarcoma recurrences in pediatric patients previously treated with intensive chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome; Vindesine | 1994 |
Acute urticaria and hepatitis complicating high-dose methotrexate therapy.
Topics: Acute Disease; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Humans; Methotrexate; Osteosarcoma; Urticaria | 1995 |
Methotrexate pharmacokinetics and prognosis in osteosarcoma.
Topics: Actuarial Analysis; Adolescent; Adult; Child; Child, Preschool; Humans; Methotrexate; Osteosarcoma; Prognosis; Retrospective Studies; Statistics as Topic; Survival Analysis | 1994 |
High-dose methotrexate treatment and liver function in patients with osteosarcoma.
Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Bone Neoplasms; Cisplatin; Doxorubicin; Female; Galactose; Humans; Liver; Liver Function Tests; Male; Methotrexate; Osteosarcoma; Prospective Studies | 1994 |
Hyperthermic isolated perfusion using cisplatin for treatment of the extremities.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Fibula; Follow-Up Studies; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Male; Methotrexate; Necrosis; Osteosarcoma; Tibia; Tissue Distribution; Treatment Outcome | 1993 |
Diffusion of methotrexate from surgical acrylic cement.
Topics: Acrylates; Bone Cements; Bone Neoplasms; Chemotherapy, Adjuvant; Diffusion; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Pharmaceutical Vehicles | 1993 |
Adjuvant interferon treatment in human osteosarcoma.
Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Immunologic Factors; Interferon-alpha; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate | 1993 |
[The importance of dose intensity in preoperative chemotherapy for osteosarcoma--retrospective analysis of a short intensive chemotherapy regimen preoperatively using high-dose methotrexate and cisplatinum].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies; Survival Rate | 1994 |
Cerebral arterial disturbances in a transient encephalopathy induced by methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Humans; Leucovorin; Methotrexate; Osteosarcoma; Seizures; Syndrome | 1993 |
[Long-term follow-up results after heavy dose chemotherapy of primary malignant bone tumors of the limbs].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Doxorubicin; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Tibia | 1993 |
[Chemotherapy for osteosarcoma--trends in recent years].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma | 1993 |
Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Femur; Humans; Humerus; Infusions, Intravenous; Injections, Intra-Arterial; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Complications; Preoperative Care; Remission Induction; Survival Rate; Tibia | 1993 |
Wernicke-encephalopathy in children with cancer.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Tibia; Wernicke Encephalopathy | 1994 |
Impact of omeprazole on the plasma clearance of methotrexate.
Topics: Adult; Bone Neoplasms; Contraindications; Humans; Male; Metabolic Clearance Rate; Methotrexate; Omeprazole; Osteosarcoma | 1993 |
Proteinuria due to suboptimal hydration with high-dose methotrexate therapy.
Topics: Adolescent; Bone Neoplasms; Burkitt Lymphoma; Child; Female; Fluid Therapy; Glomerular Filtration Rate; Glucose; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteinuria; Sodium Bicarbonate | 1993 |
Pelvic osteosarcoma: problems in management.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cote d'Ivoire; Cyclophosphamide; Doxorubicin; Fatal Outcome; Female; Health Care Rationing; Humans; Methotrexate; Osteosarcoma; Pelvic Neoplasms; Prednisolone | 1994 |
[A pharmacokinetic study on high-dose methotrexate administration--the effects of volume changes of parenteral solutions on the elimination rate].
Topics: Bone Neoplasms; Female; Humans; Infusions, Parenteral; Mathematics; Methotrexate; Osteosarcoma | 1994 |
Substitution of l-leucovorin for d,l-leucovorin in the rescue from high-dose methotrexate treatment in patients with osteosarcoma.
Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Humans; Kidney Function Tests; Leucovorin; Leukocyte Count; Liver Function Tests; Methotrexate; Osteosarcoma; Retrospective Studies; Stereoisomerism | 1993 |
Pharmacokinetics of high-dose methotrexate in adult osteogenic sarcoma.
Topics: Adolescent; Adult; Bayes Theorem; Drug Administration Schedule; Humans; Infusions, Intravenous; Methotrexate; Middle Aged; Osteosarcoma | 1994 |
[32 cases of postoperative osteogenic sarcoma treated by chemotherapy combined with Chinese medicinal herbs].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Dexamethasone; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Period; Vincristine; Vomiting | 1993 |
Pathological responses to preoperative high-dose methotrexate chemotherapy in osteosarcoma--experience in Korea cancer hospital.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma | 1993 |
Improved results in osteogenic sarcoma 1973-79 vs. 1980-86: analysis of results from a single center.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Life Expectancy; Male; Methotrexate; Osteosarcoma; Platinum; Prognosis; Survival Analysis; Treatment Outcome | 1993 |
Determination of methotrexate in human urine at nanomolar levels by high-performance liquid chromatography with column switching.
Topics: Bone Neoplasms; Chromatography, High Pressure Liquid; Freezing; Humans; Indicators and Reagents; Methotrexate; Nursing; Occupational Exposure; Osteosarcoma; Quality Control | 1993 |
Serum methotrexate (MTX) concentrations and prognosis in patients with osteosarcoma of the extremities treated with a multidrug neoadjuvant regimen.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Etoposide; Extremities; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Prognosis | 1993 |
Targeted delivery of antineoplastic agent to bone: biodistribution studies of technetium-99m-labeled gem-bisphosphonate conjugate of methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Bone and Bones; Bone Neoplasms; Diphosphonates; Male; Methotrexate; Mice; Osteosarcoma; Rabbits; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Tissue Distribution | 1996 |
Localized cisplatin hyperpigmentation induced by pressure. A case report.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Hyperpigmentation; Male; Methotrexate; Osteosarcoma; Pressure | 1996 |
High-dose methotrexate-induced bullous variant of acral erythema.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chondrosarcoma; Erythema; Female; Humans; Methotrexate; Osteosarcoma; Skin Diseases, Vesiculobullous | 1996 |
Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Female; Femoral Neoplasms; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma | 1995 |
[Current aspects of the treatment of osteogenic sarcoma].
Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Osteosarcoma; Platinum; Time Factors | 1995 |
Long-term pulmonary toxicity of multiagent chemotherapy including bleomycin and cyclophosphamide in osteosarcoma survivors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Forced Expiratory Volume; Humans; Lung; Methotrexate; Osteosarcoma; Pulmonary Diffusing Capacity; Total Lung Capacity | 1996 |
Musculoskeletal tumour disorders.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Humans; Methotrexate; Necrosis; Osteosarcoma | 1996 |
[Preliminary evaluation of individualized use of large doses of methotrexate for treatment of osteosarcoma in children and adolescents].
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Osteosarcoma | 1995 |
[A device for rapid elevation of plasma methotrexate (MTX) concentration and its maintenance in high-dose MTX therapy].
Topics: Adolescent; Adult; Bone Neoplasms; Child; Female; Fluorescence Polarization Immunoassay; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma | 1996 |
[Preoperative and postoperative chemotherapy of osteogenic sarcoma of the limbs in children].
Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Postoperative Care; Preoperative Care; Survival Rate; Time Factors; Vincristine | 1996 |
[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].
Topics: Antineoplastic Agents; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Kidney; Liver; Methotrexate; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia | 1996 |
Methotrexate serum concentration and histological response to multiagent primary chemotherapy for osteosarcoma of the limbs.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Prognosis | 1996 |
Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma | 1997 |
Neoadjuvant chemotherapy for pediatric osteosarcoma patients.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Retrospective Studies | 1997 |
Methotrexate osteopathy in patients with osteosarcoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Diseases; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Osteosarcoma; Radiography; Retrospective Studies | 1997 |
Prognostic significance of chemotherapy dosage characteristics in children with osteogenic sarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Humans; Methotrexate; Multivariate Analysis; Osteosarcoma; Prognosis; Retrospective Studies | 1997 |
[High-dose methotrexate and cerebral neurotoxicity. Apropos of a case of arachnoiditis].
Topics: Adult; Antimetabolites, Antineoplastic; Arachnoiditis; Bone Neoplasms; Encephalitis; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Tibia | 1997 |
Effect of methotrexate and sulphasalazine on UMR 106 rat osteosarcoma cells.
Topics: Alkaline Phosphatase; Animals; Antirheumatic Agents; Bone Neoplasms; Cell Count; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Leucovorin; Methotrexate; Osteosarcoma; Rats; Sulfapyridine; Sulfasalazine; Tumor Cells, Cultured; Vitamin D | 1997 |
B7-1-transfected tumor vaccine counteracts chemotherapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; B7-1 Antigen; Cancer Vaccines; Cell Membrane; Lung Neoplasms; Male; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Inbred F344; Survival Analysis; T-Lymphocytes; Transfection | 1997 |
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; Doxorubicin; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methotrexate; Osteosarcoma; Phosphorylation; Quinazolines; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Tetracycline; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1997 |
Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma: analysis of the literature.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma | 1997 |
Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity: results in 18 cases and comparison with 112 contemporary osteosarcoma patients treated with the same chemotherapy regimen.
Topics: Adolescent; Adult; Amputation, Surgical; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Leg; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma | 1997 |
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Humans; Male; Methotrexate; Microdialysis; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Nude; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
[The application of intraarterial chemotherapy for the treatment of osteogenic sarcoma in children].
Topics: Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Osteosarcoma | 1997 |
Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies | 1998 |
Neoadjuvant chemotherapy for extremity osteosarcoma--preliminary results of the Rizzoli's 4th study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Preoperative Care | 1998 |
Augmentation of anti-tumor effects of methotrexate by distilled water on Dunn osteosarcoma in mouse air pouch.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Synergism; Male; Methotrexate; Mice; Mice, Inbred C3H; Osteosarcoma; Solutions; Water | 1998 |
Monitoring methotrexate levels in osteosarcoma.
Topics: Chemotherapy, Adjuvant; Humans; Methotrexate; Osteosarcoma; Prognosis; Retrospective Studies | 1998 |
Effect of methotrexate on distraction osteogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Neoplasms; Bone Regeneration; Calcification, Physiologic; Calcium; Disease Models, Animal; External Fixators; Female; Humans; Ilizarov Technique; Methotrexate; Osteogenesis, Distraction; Osteosarcoma; Phosphorus; Placebos; Rabbits; Radiography; Random Allocation; Tibia | 1998 |
[Carboxypeptidase-G2 rescue of methotrexate intoxication].
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Osteosarcoma; Poisoning | 1998 |
Ifosfamide/etoposide alternating with high-dose methotrexate: evaluation of a chemotherapy regimen for poor-risk osteosarcoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Recurrence; Retrospective Studies | 1999 |
Mechanisms of methotrexate resistance in osteosarcoma.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Biological Transport; Blotting, Southern; Carrier Proteins; Child; Drug Resistance, Neoplasm; Female; Gene Amplification; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; RNA, Messenger; Tetrahydrofolate Dehydrogenase | 1999 |
Accumulation of methotrexate in human tissues following high-dose methotrexate therapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Gallbladder; Humans; Kidney; Liver; Male; Methotrexate; Muscle, Skeletal; Osteosarcoma; Tissue Distribution | 1998 |
High-dose leucovorin as sole therapy for methotrexate toxicity.
Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Creatinine; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Kidney; Leucovorin; Methotrexate; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia | 1999 |
Omeprazole does not alter plasma methotrexate clearance.
Topics: Adult; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Kidney; Male; Methotrexate; Omeprazole; Osteosarcoma | 1999 |
Prognostic factors in non-metastatic limb osteosarcoma: A 20-year experience of one center.
Topics: Adolescent; Alkaline Phosphatase; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Cohort Studies; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Israel; L-Lactate Dehydrogenase; Leucovorin; Life Tables; Male; Methotrexate; Neoplasm Proteins; Neoplasm Staging; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies; Risk Factors; Salvage Therapy; Survival Analysis; Treatment Outcome; Vincristine | 1999 |
Prognostic value of DNA ploidy response to chemotherapy in human osteosarcomas.
Topics: Adolescent; Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Osteosarcoma; Ploidies; Prognosis | 1999 |
Osteosarcoma of the pelvis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Cisplatin; Doxorubicin; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Survival Rate | 1999 |
Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy Dosage; Rhabdomyosarcoma; Sarcoma, Ewing | 1999 |
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Cisplatin; Cyclophosphamide; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Humans; Methotrexate; Oligopeptides; Osteosarcoma; Tumor Cells, Cultured; Vincristine | 2000 |
Successful rescue by oral cholestyramine of a patient with methotrexate nephrotoxicity: nonrenal excretion of serum methotrexate.
Topics: Anion Exchange Resins; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Cholestyramine Resin; Humans; Kidney; Liver; Male; Methotrexate; Osteosarcoma; Tibia; Time Factors; Treatment Outcome | 2000 |
[Primary chemotherapy with the Rosen T10 protocol before conservative surgery in limb primitive osteosarcomas: results about 56 cases].
Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; L-Lactate Dehydrogenase; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Prospective Studies; Survival Analysis; Tomography, X-Ray Computed; Vincristine | 2000 |
Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Caspases; Cisplatin; Doxorubicin; Enzyme Activation; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Methotrexate; Mitochondria; Osteosarcoma; Tumor Cells, Cultured | 2000 |
[The analysis of failures in therapy of osteosarcoma in children treated according to SFOP-94 protocol in the studies of Polish pediatric solid tumors treatment group].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Poland; Retrospective Studies; Survival Rate; Treatment Failure | 1998 |
[Toxicosis of high-dose methotrexate (HD-MTX) for osteosarcoma, cured with treatment by leucovorin (LV) rescue and hemoperfusion--a case report].
Topics: Adolescent; Antimetabolites, Antineoplastic; Arthroplasty, Replacement, Knee; Combined Modality Therapy; Femoral Neoplasms; Hemoperfusion; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Vincristine | 2000 |
Cytotoxic effect of methotrexate and its solvent on osteosarcoma cells in vitro.
Topics: Antimetabolites, Antineoplastic; Bone Cements; Bone Neoplasms; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Drug Implants; Humans; In Vitro Techniques; Methotrexate; Osteoblasts; Osteosarcoma; Pyrrolidinones; Tumor Cells, Cultured | 1999 |
Anaplastic osteosarcoma with abundant eosinophilic cytoplasm and minimal osteoid production.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Cytoplasm; Doxorubicin; Drug Therapy, Combination; Eosine Yellowish-(YS); Fatal Outcome; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methotrexate; Neoplasm Proteins; Osteosarcoma; Staining and Labeling; Tibia; Tomography, X-Ray Computed | 2000 |
Allergic reaction to high-dose methotrexate.
Topics: Adolescent; Anti-Anxiety Agents; Antimetabolites, Antineoplastic; Antipruritics; Bone Neoplasms; Diphenhydramine; Drug Eruptions; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Immunosuppressive Agents; Male; Methotrexate; Ondansetron; Osteosarcoma; Premedication; Tibia; Urticaria | 2000 |
Potential interaction between methotrexate and omeprazole.
Topics: Child; Drug Interactions; Enzyme Inhibitors; Folic Acid Antagonists; Half-Life; Humans; Inactivation, Metabolic; Male; Methotrexate; Omeprazole; Osteosarcoma | 2000 |
High-dose methotrexate is lethal to rats. Why give it to children?
Topics: Animals; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats | 2000 |
Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: long-term results for patients treated according to the Rizzoli IOR/OS-3b protocol.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Time Factors; Treatment Outcome | 2001 |
Transient posterior encephalopathy induced by chemotherapy in children.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Cyclophosphamide; Dactinomycin; Female; Humans; Hypertension; Magnesium Deficiency; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Radiopharmaceuticals; Remission Induction; Syndrome; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2001 |
Methotrexate poisoning with acute hepatorenal dysfunction.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Hemofiltration; Humans; Liver Diseases; Methotrexate; Osteosarcoma; Plasma Exchange; Renal Dialysis; Treatment Outcome | 2001 |
Histologic response of high-grade nonmetastatic osteosarcoma of the extremity to chemotherapy,.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Logistic Models; Male; Methotrexate; Multivariate Analysis; Osteonecrosis; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Treatment Outcome | 2001 |
Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Multiple Primary; Osteosarcoma; Survival Rate; Treatment Outcome | 2001 |
Long-term local intensive preoperative chemotherapy and joint-preserving conservative surgery for osteosarcoma around the knee.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Femoral Neoplasms; Humans; Hyperthermia, Induced; Infusions, Intravenous; Injections, Intra-Arterial; Knee Joint; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Osteotomy; Preoperative Care; Tibia; Time Factors; Treatment Outcome | 2001 |
[Methotrexate-ciprofloxacin interaction: report of two cases of severe intoxication].
Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Ciprofloxacin; Drug Interactions; Female; Humans; Male; Methotrexate; Neuroblastoma; Osteosarcoma | 2001 |
Adjuvant chemotherapy for osteosarcoma may not increase survival after neoadjuvant chemotherapy and surgical resection.
Topics: Adolescent; Adult; Aged; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Survival Rate | 2001 |
High-dose methotrexate in fibroblastic osteosarcoma.
Topics: Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Dose-Response Relationship, Drug; Half-Life; Humans; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma | 2001 |
The cytotoxic effect of methotrexate loaded bone cement on osteosarcoma cell lines.
Topics: Antimetabolites, Antineoplastic; Bone Cements; Bone Neoplasms; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Methotrexate; Osteosarcoma; Tumor Cells, Cultured | 2001 |
[Flow cytometry for testing chemosensitivity of malignant bone tumors].
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorouracil; Humans; Methotrexate; Mitomycin; Osteosarcoma | 1999 |
Significant impairment of high-dose methotrexate clearance following vancomycin administration in the absence of overt renal impairment.
Topics: Adult; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Vancomycin | 2002 |
[A case of subacute transient cerebral dysfunction in a osteosarcoma patient following high-dose methotrexate].
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bone Neoplasms; Brain Diseases; Cisplatin; Drug Administration Schedule; Humans; Male; Methotrexate; Osteosarcoma | 2002 |
[An autopsy case of pulmonary and central nervous system metastatic osteosarcoma treated with thirty-six courses of chemotherapy over four years].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carboplatin; Cisplatin; Dacarbazine; Deoxycytidine; Docetaxel; Drug Administration Schedule; Etoposide; Gemcitabine; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Paclitaxel; Spinal Cord Neoplasms; Survivors; Taxoids; Vincristine; Vindesine | 2002 |
Interaction between methotrexate and ciprofloxacin.
Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Ciprofloxacin; Drug Interactions; Female; Humans; Male; Methotrexate; Neuroblastoma; Osteosarcoma | 2002 |
[Results of treatment of osteosarcoma in children according to the SFOP-94 protocol in the experience of the Polish Paediatric Solid Tumour Study Group].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Female; Femur; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Poland; Remission Induction; Retrospective Studies; Tibia; Time Factors | 2000 |
Improvement in the results of treatment of osteogenic sarcoma.
Topics: Adolescent; Adult; Age Factors; Aged; Amputation, Surgical; Bone Neoplasms; Child; Doxorubicin; Hemipelvectomy; Humans; Leg; Lung Neoplasms; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Palliative Care; Pneumonectomy; Remission, Spontaneous | 1975 |
[Clinical observations on the use of high-dose methotrexate treatment in osteogenic sarcoma (author's transl)].
Topics: Adolescent; Adult; Bleomycin; Bone Neoplasms; Child; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Vincristine | 1977 |
[Therapy of malignant tumors through the internist].
Topics: Bleomycin; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Melphalan; Methotrexate; Osteosarcoma; Plasmacytoma; Prednisone; Sarcoma, Ewing; Vincristine | 1977 |
Malignant bone tumors: spindle-cell sarcomas.
Topics: Adolescent; Amputation, Surgical; Bleomycin; Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Preoperative Care; Prostheses and Implants; Radiography; Vincristine | 1978 |
Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery.
Topics: Adolescent; Adult; Antineoplastic Agents; Bleomycin; Bone Neoplasms; Brain; Child; Cyclophosphamide; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Time Factors; Vincristine | 1979 |
Clinical use of high dose methotrexate within the Queensland Radium Institute.
Topics: Australia; Carcinoma, Squamous Cell; Child; Chondrosarcoma; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Palliative Care; Teratoma; Testicular Neoplasms | 1979 |
High-dose methotrexate for the patient with osteogenic sarcoma.
Topics: Administration, Oral; Adolescent; Amphotericin B; Anorexia; Blood Platelets; Blood Transfusion; Candidiasis; Drug Eruptions; Humans; Infusions, Parenteral; Injections, Intramuscular; Leucovorin; Methotrexate; Nausea; Osteosarcoma; Pneumothorax; Stomatitis; Vomiting | 1976 |
[Cellular immunity during and after high-dose methotrexate therapy in patients with osteosarcoma (author's transl)].
Topics: Adolescent; Adult; Child; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Methotrexate; Mitogens; Osteosarcoma | 1977 |
From wild fowl to stalking horses: alchemy in chemotherapy. Fifth annual David A. Karnofsky Memorial Lecture.
Topics: Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Brain Neoplasms; Drug Therapy, Combination; History, 20th Century; Hodgkin Disease; Humans; Infections; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Wilms Tumor | 1975 |
Childhood cancer: the improving prognosis.
Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Rhabdomyosarcoma; Teniposide; Thioguanine; Vincristine; Wilms Tumor | 1976 |
Osteogenic sarcoma in a patient with aplastic anemia.
Topics: Adolescent; Anemia, Aplastic; Bone Neoplasms; Chloramphenicol; Humans; Male; Methotrexate; Osteosarcoma; Prednisone; Testosterone | 1977 |
[Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].
Topics: Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Radioimmunoassay | 1977 |
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; Metronidazole; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Sarcoma, Ewing | 1977 |
Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate.
Topics: Adolescent; Adult; Anaphylaxis; BCG Vaccine; Bone Neoplasms; Drug Contamination; Humans; Injections, Intravenous; Male; Methotrexate; Osteosarcoma | 1978 |
Sarcoidosis following adjuvant high-dose methotrexate therapy for osteosarcoma.
Topics: Adolescent; Amputation, Surgical; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Radiography; Sarcoidosis | 1978 |
Pulmonary resection in children with metastatic osteogenic sarcoma: improved survival with surgery, chemotherapy, and irradiation.
Topics: Adolescent; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonectomy; Prognosis; Radiography; Vincristine | 1978 |
Proceedings of the Osteosarcoma Study Group Meeting (Bethesda, Maryland, January 19, 1977): introduction: treatment of osteogenic sarcoma.
Topics: Humans; Methotrexate; Osteosarcoma | 1978 |
[Malignant juvenile bone tumors].
Topics: Adolescent; Adult; Aged; Amputation, Surgical; Bone Neoplasms; Child; Diagnosis, Differential; Doxorubicin; Drug Therapy, Combination; Eosinophilic Granuloma; Female; Folic Acid; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteomyelitis; Osteosarcoma; Sarcoma, Ewing | 1978 |
[Bone and soft tissue sarcomas].
Topics: Aged; Child; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Therapy, Combination; Female; Humans; Life Expectancy; Methotrexate; Osteosarcoma; Prednisone; Remission, Spontaneous; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine | 1978 |
Osteogenic sarcoma complicating osteogenesis imperfecta tarda.
Topics: Adolescent; Amputation, Surgical; Femoral Neoplasms; Humans; Male; Methotrexate; Osteogenesis Imperfecta; Osteosarcoma | 1978 |
[First experiences after exclusive radiotherapy of primary bone tumors (proceedings)].
Topics: Adolescent; Adult; Bone Neoplasms; Chondrosarcoma; Cobalt Radioisotopes; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1978 |
[First results of adjuvant chemotherapy in osteosarcoma (proceedings)].
Topics: Doxorubicin; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
[5 year study on 88 osteosarcoma patients with combined surgical and adriamycin treatment (proceedings)].
Topics: Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Osteosarcoma; Prognosis | 1978 |
Characterization of methotrexate recovered from the urine of high dose patients for the purpose of clinical re-use.
Topics: Adolescent; Adult; Animals; Chromatography, Ion Exchange; Female; Humans; Leukemia, Experimental; Male; Methotrexate; Mice; Osteosarcoma; Pyrogens; Spectrophotometry, Ultraviolet | 1978 |
[Osteosarcoma 1978 a turning point in prognosis through adjuvant chemotherapy following adequate surgery (author's transl)].
Topics: Adolescent; Amputation, Surgical; Bone Neoplasms; Child; Cyclophosphamide; Female; Femur; Humans; Humerus; Male; Melphalan; Methotrexate; Mitomycins; Osteosarcoma; Prognosis; Prostheses and Implants; Tibia | 1978 |
Current trends and prospects in surgical adjuvant trials.
Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Dianhydrogalactitol; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Rectal Neoplasms | 1978 |
Age-related pharmacokinetics of high-dose methotrexate in patients with osteosarcoma.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Kinetics; Methotrexate; Middle Aged; Osteosarcoma | 1979 |
[Radioimmunoassay of methotrexate during treatment using high doses].
Topics: Adolescent; Adult; Breast Neoplasms; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Radioimmunoassay; Time Factors | 1979 |
Adjuvant therapy in the management of osteosarcoma: need for critical reassessment.
Topics: Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1978 |
[Multidrug chemotherapy of osteogenic sarcoma (author's transl)].
Topics: Doxorubicin; Humans; Methotrexate; Osteosarcoma; Postoperative Care | 1979 |
Vincristine-methotrexate combination chemotherapy and the influence of weight loss on experimental tumour growth.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Starvation; Vincristine | 1979 |
[The use and side effects of chemotherapy in the treatment of malignant bone tumors (osteosarcoma and Ewing's sarcoma) (author's transl)].
Topics: Adolescent; Adult; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1979 |
Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.
Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Necrosis; Osteocytes; Osteosarcoma; Tibia; Vincristine | 1977 |
Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma: pre-surgical treatment of primary tumor and of overt pulmonary metastases.
Topics: Bone Neoplasms; Drug Administration Schedule; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission, Spontaneous; Vincristine | 1977 |
Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1977 |
Total femur replacement.
Topics: Adolescent; Adult; Aged; Child; Chondrosarcoma; Cyclophosphamide; Doxorubicin; Female; Femoral Neoplasms; Femur; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Postoperative Complications; Prostheses and Implants; Vincristine | 1977 |
Multidisciplinary treatment for childhood sarcoma.
Topics: Adolescent; Age Factors; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Leucovorin; Lymphatic Metastasis; Male; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine | 1977 |
Osteosarcoma during pregnancy.
Topics: Abortion, Induced; Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pregnancy; Pregnancy Complications; Vincristine | 1977 |
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine | 1977 |
High-dose methotrexate with citrovorum factor in osteogenic sarcoma--progress report II.
Topics: Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1977 |
Current concepts in the management of disseminated malignant bone disease in childhood.
Topics: Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Sarcoma, Ewing; Vincristine | 1977 |
Surgical management of malignant bone tumours.
Topics: Adult; Amputation, Surgical; Bone Neoplasms; Child; Chondrosarcoma; Fibrosarcoma; Humans; Leucovorin; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1977 |
Effect of hydration on plasma-methotrexate levels.
Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Sodium; Solutions; Water | 1977 |
[Chemotherapy of osteosarcoma (author's transl)].
Topics: Adolescent; Age Factors; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methods; Methotrexate; Osteosarcoma; Time Factors | 1977 |
Pathologic aspects of chemotherapy response in the treatment of osteogenic sarcoma. An analysis of two cases.
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Tibia | 1977 |
Limb preservation in osteogenic sarcoma: a preliminary report.
Topics: Adolescent; Antineoplastic Agents; Doxorubicin; Femur; Humans; Humerus; Injections, Intra-Arterial; Leucovorin; Methotrexate; Osteosarcoma; Prostheses and Implants; Tibia; Vincristine | 1977 |
High-dose methotrexate, not a conventional treatment.
Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Research Design | 1978 |
Adjuvant chemotherapy of osteogenic sarcoma: progress and perspectives.
Topics: Antineoplastic Agents; Cell Count; Cell Survival; Child; Drug Resistance; Drug Therapy, Combination; Female; Humans; Kinetics; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
Patient case involving high-dose methotrexate followed by leucovorin rescue.
Topics: Adolescent; Drug Therapy, Combination; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1978 |
Chemotherapy and thoractomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery.
Topics: Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
"Single"-agent activity of high-dose methotrexate with citrovorum factor rescue.
Topics: Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Osteosarcoma; Vincristine | 1978 |
[High-dose methotrexate/leucovorin adjuvant chemotherapy of osteogenic sarcoma: biochemical effects in DNA-synthesis of bone marrow cells (author's transl)].
Topics: Bone Marrow; Bone Neoplasms; DNA; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1978 |
Serum copper and zinc measurement in patients with osteogenic sarcoma.
Topics: Adolescent; Adult; BCG Vaccine; Copper; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Recurrence; Spectrometry, X-Ray Emission; Time Factors; Zinc | 1978 |
Degradation and clearance of methotrexate in children with osteosarcoma receiving high-dose infusion.
Topics: Adolescent; Child; Child, Preschool; Half-Life; Humans; Injections, Intravenous; Leucovorin; Methotrexate; Osteosarcoma; Time Factors | 1978 |
Osteosarcoma--the winds of change.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1978 |
[Chemotherapy of osteo and Ewing sarcomas].
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission, Spontaneous; Sarcoma, Ewing; Vincristine | 1978 |
[Experiences with high dose methotrexate treatments within the framework of polychemotherapy in osteosarcoma (proceedings)].
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
Transient cerebral dysfunction following chemotherapy for osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Brain Diseases; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Humerus; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pelvic Bones; Syndrome; Vincristine | 1978 |
High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma.
Topics: Animals; Bone Neoplasms; Dog Diseases; Dogs; Female; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1978 |
High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer.
Topics: Adolescent; Adult; Aged; Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma | 1979 |
[High-dose methotrexate therapy in osteogenic sarcoma: plasma pharmakokinetics to predict toxicity (author's transl)].
Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Creatinine; Humans; Leucovorin; Methotrexate; Osteosarcoma; Radioimmunoassay; Stomatitis | 1979 |
[Course of metastatic osteogenic sarcoma treated with chemotherapy only (author's transl)].
Topics: Antineoplastic Agents; Child; Doxorubicin; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiography; Remission, Spontaneous; Sacrum; Vincristine | 1979 |
Evaluation of overall toxicity of high-dosage methotrexate regimens.
Topics: Adolescent; Age Factors; Bone Marrow; Bone Neoplasms; Child; Dermatitis; Drug Administration Schedule; Female; Humans; Kidney; Leucovorin; Leukopenia; Liver; Male; Methotrexate; Osteosarcoma; Sex Factors; Stomatitis; Thrombocytopenia; Vincristine | 1979 |
Serum levels of methotrexate by the ligand-binding assay after "high-dose" therapy for osteosarcoma.
Topics: Drug Therapy, Combination; Humans; Leucovorin; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Tetrahydrofolate Dehydrogenase | 1979 |
Effect of high-dose methotrexate with citrovorum factor on human granulopoiesis.
Topics: Bone Marrow; Colony-Forming Units Assay; Drug Therapy, Combination; Granulocytes; Hematopoiesis; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1979 |
Significance of the 48-hour plasma level in high-dose methotrexate regimens.
Topics: Adolescent; Adult; Age Factors; Bone Marrow; Child; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Liver; Methotrexate; Osteosarcoma; Time Factors | 1978 |
The biochemistry of the citrovorum factor rescue effect in normal bone marrow cells after high-dose methotrexate.
Topics: Adult; Bone Marrow; Cells, Cultured; Deoxyuridine; Humans; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Osteosarcoma; Thymidine; Thymidine Kinase | 1979 |
Pharmacokinetic monitoring of high-dose methotrexate. Early recognition of high-risk patients.
Topics: Bone Neoplasms; Drug Therapy, Combination; Half-Life; Humans; Kinetics; Leucovorin; Methotrexate; Osteosarcoma; Risk; Time Factors | 1979 |
Treatment of osteosarcoma.
Topics: Adolescent; Antineoplastic Agents; Child; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1979 |
Radiation in bone sarcomas: a re-evaluation in the era of intensive systemic chemotherapy.
Topics: Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiation Tolerance; Radiotherapy Dosage; Radiotherapy, High-Energy; Sarcoma, Ewing; Vincristine | 1977 |
Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma.
Topics: Adolescent; Adult; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy | 1977 |
Management of osteogenic sarcoma at the Mayo Clinic.
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Drug Therapy, Combination; Female; Humans; Immunotherapy; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Radiotherapy, High-Energy; Transfer Factor; Vincristine | 1976 |
Editorial: New therapies for osteogenic sarcoma.
Topics: Amputation, Surgical; Bone Neoplasms; Doxorubicin; Humans; Immunotherapy; Lymphocytes; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1975 |
[Association of radical surgery and cyclic polychemotherapy (with vincristine, methotrexate and adriamycin) in the treatment of some forms of osteosarcoma. Preliminary results].
Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Care; Vincristine | 1975 |
Assay of cell-mediated cytotoxicity by tritiated thymidine labeled tumor cells.
Topics: Autoradiography; Cytotoxicity Tests, Immunologic; Fibroblasts; Humans; Immunity, Cellular; Isotope Labeling; Lymphocytes; Methotrexate; Osteosarcoma; Thymidine; Tritium | 1975 |
Chemotherapy of osteosarcoma.
Topics: Amputation, Surgical; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lung Neoplasms; Melphalan; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1975 |
A case of osteogenic sarcoma of maxillary antrum cure by radiation therapy.
Topics: Adolescent; Female; Humans; Maxillary Sinus; Methotrexate; Osteosarcoma; Paranasal Sinus Neoplasms; Radiotherapy Dosage; Time Factors | 1975 |
Investigation of carbohydrate metabolism and somatomedin in osteosarcoma patients.
Topics: Adolescent; Bone Development; Carbohydrate Metabolism; Cartilage; Cells, Cultured; Estradiol; Female; Growth Hormone; Humans; Male; Methotrexate; Osteosarcoma; Sex Factors; Somatomedins | 1975 |
Toxicity of doxorubicin and methotrexate in osteogenic sarcoma.
Topics: Adolescent; Doxorubicin; Drug Therapy, Combination; Female; Humans; Methotrexate; Osteosarcoma; Time Factors; Vincristine | 1976 |
[Supplementary antiblastic polychemotherapy in localized malignant bone tumors. I. Ewing's sarcoma and osteosarcoma].
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Sarcoma, Ewing; Vincristine | 1975 |
7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.
Topics: Adult; Animals; Bone Neoplasms; Carcinoma, Squamous Cell; Child; Female; Histocytochemistry; Humans; Kidney; Lung Neoplasms; Macaca mulatta; Male; Methotrexate; Middle Aged; Osteosarcoma; Time Factors | 1976 |
The results of surgical treatment combined with intra-arterial infusion of anti-cancer agents in osteosarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Extremities; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Male; Methotrexate; Mitomycins; Osteosarcoma | 1976 |
Effects of methotrexate on deoxyribonucleotide pools and nucleic acid synthesis in human osteosarcoma cells.
Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Breast Neoplasms; Cells, Cultured; Deoxyribonucleotides; Deoxyuridine; DNA; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; RNA; Time Factors | 1976 |
Immunotherapy of osteosarcoma patients with virus-modified tumor cells.
Topics: Adolescent; Adult; Antibodies, Neoplasm; Antibodies, Viral; Antibody Formation; Bone Neoplasms; Cell Line; Child; Female; Humans; Immunity, Cellular; Immunization; Immunotherapy; Kinetics; Male; Methotrexate; Orthomyxoviridae; Osteosarcoma; Vaccines | 1976 |
Primary malignant tumours of bone.
Topics: Adolescent; Amputation, Surgical; Animals; Bone Neoplasms; Child; Chondrosarcoma; Dogs; Doxorubicin; Fibrosarcoma; Giant Cell Tumors; Humans; Methotrexate; Middle Aged; Osteosarcoma; Vincristine | 1976 |
Adjuvant chemotherapy associated with surgery in the treatment of osteosarcoma. Preliminary results.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Depression, Chemical; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Immunity; Male; Methotrexate; Middle Aged; Osteosarcoma; Vincristine | 1976 |
Letter: Limitations of methotrexate and citrovorum-factor treatment.
Topics: Adult; Antineoplastic Agents; Child; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1975 |
Letter: Management of osteogenic sarcoma.
Topics: Adult; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1975 |
The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy.
Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1975 |
Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma.
Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonia; Pulmonary Fibrosis; Spinal Cord Compression | 1975 |
The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma.
Topics: Adolescent; Bone Neoplasms; Child; Cyclophosphamide; Digestive System; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Leucovorin; Male; Methotrexate; Mouth Mucosa; Mucous Membrane; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1975 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides | 1975 |
Letter: Osteosarcoma--new hope.
Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1975 |
Letter: Methotrexate-citrovorum factor in treating osteogenic sarcoma.
Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1975 |
Femur replacement.
Topics: Adolescent; Adult; Drug Therapy, Combination; Femoral Neoplasms; Femur; Humans; Joint Prosthesis; Leucovorin; Male; Methotrexate; Osteosarcoma | 1975 |
The treatment of pulmonary metastasis in osteogenic sarcoma.
Topics: Bone Neoplasms; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1975 |
Combined radiosensitizer infusion and irradiation of osteogenic sarcomas.
Topics: Bromodeoxyuridine; Child; Female; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Osteosarcoma; Radiation Dosage; Radiation-Sensitizing Agents | 1975 |
Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Femur; Hip Joint; Humans; Joint Prosthesis; Knee Joint; Leucovorin; Male; Methotrexate; Osteosarcoma; Prostheses and Implants; Tibia; Vincristine | 1976 |
Failure of leucovorin rescue to prevent reactivation of a solar burn after high dose methotrexate.
Topics: Adult; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Skin; Sunburn | 1976 |
Multidrug chemotherapy in pulmonary treatment of osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Melphalan; Methotrexate; Middle Aged; Osteosarcoma; Vincristine | 1976 |
Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.
Topics: Adolescent; Adult; Child; Female; Humans; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Osteosarcoma | 1976 |
Osteogenic sarcoma: state of the art with high-dose methotrexate treatment.
Topics: Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Vincristine | 1976 |
Chemotherapy of osteosarcoma [proceedings].
Topics: Bone Neoplasms; Child; Dacarbazine; Doxorubicin; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine | 1976 |
Multidisciplinary treatment for macrometastatic osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Leucovorin; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Vincristine | 1976 |
Plasma amino acids during high-dose methotrexate-citrovorum "rescue".
Topics: Adult; Amino Acids; Cysteine; Humans; Kinetics; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine | 1976 |
Encapsulation around malignant bone tumors after preoperative adjuvant treatment.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Histiocytoma, Benign Fibrous; Humans; Injections, Intravenous; Methotrexate; Middle Aged; Osteosarcoma; Preoperative Care; Vincristine | 1992 |
Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.
Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Proportional Hazards Models; Risk Factors; Survival Analysis | 1992 |
Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Contrast Media; Doxorubicin; Drug Combinations; Female; Gadolinium; Gadolinium DTPA; Heterocyclic Compounds; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Meglumine; Methotrexate; Organometallic Compounds; Osteosarcoma; Pentetic Acid; Remission Induction; Subtraction Technique | 1992 |
Missing neutral DNase activity in lymphocytes and phytohemagglutinin-stimulated lymphocytes after high dose methotrexate therapy.
Topics: Adolescent; Bone Neoplasms; Child; Deoxyribonucleases; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Female; Humans; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Osteosarcoma | 1992 |
Appearance of a methotrexate binding plasma protein during high dose methotrexate therapy.
Topics: Adult; Blood Proteins; Dose-Response Relationship, Drug; Femoral Neoplasms; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Protein Binding | 1992 |
[Bone tumors in children. Current trends in therapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Infant; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1992 |
[Osteogenic sarcoma of the limbs: value of intra-arterial chemotherapy before surgery. Preliminary results].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Osteosarcoma; Preoperative Care; Vincristine | 1992 |
Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients.
Topics: Adolescent; Adult; Antiemetics; Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Female; Humans; Ifosfamide; Infusions, Intravenous; Injections, Intravenous; Male; Methotrexate; Nausea; Osteosarcoma; Propofol; Vomiting | 1992 |
Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Contrast Media; Doxorubicin; Female; Gadolinium; Gadolinium DTPA; Humans; Ifosfamide; Magnetic Resonance Imaging; Male; Methotrexate; Necrosis; Organometallic Compounds; Osteosarcoma; Pentetic Acid; Preoperative Care | 1992 |
Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistant tumour cell lines.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Binding, Competitive; Biological Transport; Drug Resistance; Humans; Immunotoxins; In Vitro Techniques; Methotrexate; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1992 |
Ten years' experience in patients with osteogenic sarcoma in Finland.
Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Finland; Humans; Male; Methotrexate; Osteosarcoma; Survival Rate | 1990 |
Accumulation, intracellular metabolism, and antitumor activity of high- and low-dose methotrexate in human osteosarcoma xenografts.
Topics: Animals; Body Fluids; Carbon Radioisotopes; DNA; Dose-Response Relationship, Drug; Formates; Humans; Intracellular Fluid; Liver; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Polyglutamic Acid; Transplantation, Heterologous; Tritium | 1990 |
Unusually long survival time after resection and irradiation of a brain metastasis from osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Femoral Neoplasms; Humans; Interferon Type I; Male; Methotrexate; Osteosarcoma; Prognosis | 1990 |
Preoperative intra-arterial chemotherapy in patients with osteosarcoma: case report of seven patients below the age of 18 years.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Femoral Neoplasms; Humans; Injections, Intra-Arterial; Methotrexate; Osteosarcoma; Tibia | 1990 |
Disposition of high-dose methotrexate in an obese cancer patient.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Half-Life; Humans; Leucovorin; Methotrexate; Obesity; Osteosarcoma; Tibia; Vincristine | 1991 |
Stage IIB osteogenic sarcoma.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Clinical Protocols; Cohort Studies; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; New York City; Osteosarcoma; Osteotomy; Postoperative Care; Predictive Value of Tests; Preoperative Care; Survival Analysis; Survival Rate | 1991 |
Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leg; Male; Methotrexate; Osteosarcoma; Survival Analysis | 1991 |
Secondary acute non-lymphoblastic leukemia in two children following treatment with a cis-diamminedichloroplatinum-II-based regimen for osteosarcoma.
Topics: Adolescent; Child; Cisplatin; Female; Humans; Leucovorin; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Neoplasms, Second Primary; Osteosarcoma; Vincristine | 1992 |
Can primary osteosarcoma act as a third space after high-dose methotrexate?
Topics: Adult; Bone Neoplasms; Half-Life; Humans; Male; Methotrexate; Osteosarcoma | 1991 |
[Severe methotrexate poisoning].
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Enteritis; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Poisoning; Pulmonary Fibrosis | 1991 |
2,4-diamino-7-hydroxy-pteridines, a new class of catabolites of methotrexate.
Topics: Adolescent; Adult; Animals; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hodgkin Disease; Humans; Liver; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Rabbits; Rats | 1991 |
IIB osteosarcoma. Current management, local control, and survival statistics--the Australian experience.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Australia; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Injections, Intra-Arterial; Life Tables; Male; Methotrexate; Middle Aged; Necrosis; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Complications; Radiotherapy; Remission Induction; Survival Rate | 1991 |
Recent advances in the chemotherapy of metastatic osteogenic sarcoma. 1972.
Topics: Bone Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; History, 20th Century; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Osteosarcoma | 1991 |
The management of IIB osteosarcoma. Experience from 1976 to 1985.
Topics: Adolescent; Adult; Amputation, Surgical; Austria; Bone Neoplasms; Bone Transplantation; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Complications; Prostheses and Implants; Surgical Flaps; Survival Analysis; Survival Rate | 1991 |
IIB osteosarcoma. Current management, local control, and survival statistics--São Paulo, Brazil.
Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brazil; Cisplatin; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prognosis; Prostheses and Implants; Survival Analysis; Survival Rate | 1991 |
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Lengthening; Bone Neoplasms; Bone Transplantation; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Italy; Male; Methotrexate; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prognosis; Prostheses and Implants; Survival Rate | 1991 |
Zürich experience with preoperative, high dose methotrexate-containing chemotherapy in patients with extremity osteosarcomas (OSA).
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Necrosis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate | 1991 |
Efficacy and selectivity of monoclonal-antibody-targeted drugs and free methotrexate in fluorescence-labelled mixed tumour-cell monolayer cultures and multicellular spheroids.
Topics: Antibodies, Monoclonal; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Immunotoxins; Methotrexate; Osteosarcoma; Ovarian Neoplasms; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1991 |
Increasing alkaline DNase activity with substrate specificity for denaturated DNA after high dose methotrexate therapy.
Topics: Bone Marrow; Bone Marrow Cells; Child; Deoxyribonucleases; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Isoelectric Focusing; Lymphocytes; Magnesium; Methotrexate; Nucleic Acid Hybridization; Osteosarcoma; Phytohemagglutinins; Substrate Specificity; Thymidine | 1991 |
Cell proliferation rate and tumor volume in human osteosarcoma during exposure to methotrexate. A study on tissue transplants in nude mice.
Topics: Adolescent; Animals; Autoradiography; Cell Division; Humans; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Osteosarcoma | 1991 |
Influence of chemotherapy administration on monocyte activation by liposomal muramyl tripeptide phosphatidylethanolamine in children with osteosarcoma.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Liposomes; Lung Neoplasms; Macrophage Activation; Methotrexate; Monocytes; Osteosarcoma; Phosphatidylethanolamines; Tumor Cells, Cultured | 1991 |
Osteogenic sarcoma: MR signal abnormalities of the brain in asymptomatic patients treated with high-dose methotrexate.
Topics: Brain; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Testicular Neoplasms | 1991 |
Acetazolamide for alkalinisation of urine in patients receiving high-dose methotrexate.
Topics: Acetazolamide; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Kidney; Methotrexate; Osteosarcoma | 1991 |
Combined treatment of osteosarcoma of the limbs at an advanced stage, including hyperthermic-antiblastic perfusion.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Female; Humans; Infusions, Intra-Arterial; Leg; Male; Methotrexate; Osteosarcoma; Radiography | 1990 |
Mega doses of methotrexate in the treatment of osteosarcoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Remission Induction | 1990 |
[Intra-arterial neoadjuvant chemotherapy of sarcoma of the extremities].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Follow-Up Studies; Histiocytoma, Benign Fibrous; Humans; Infusions, Intra-Arterial; Methotrexate; Middle Aged; Muscular Diseases; Osteosarcoma; Radiography | 1990 |
Acute onset deafness in a 4-year-old girl after a single infusion of cis-platinum.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Hearing Loss, Bilateral; Hearing Loss, Sensorineural; Humans; Ifosfamide; Methotrexate; Osteosarcoma | 1990 |
Neoadjuvant chemotherapy for osteosarcoma of the extremities: the Rizzoli Institute experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care | 1990 |
[The influence of liver and renal functions on the changes in serum methotrexate (MTX) level in high-dose MTX therapy].
Topics: Adolescent; Adult; Aspartate Aminotransferases; Bone Neoplasms; Child; Child, Preschool; Creatinine; Female; Humans; Kidney; Leucovorin; Liver; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Regression Analysis | 1990 |
[Adjuvant chemotherapy of osteosarcoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Humans; Male; Methotrexate; Osteosarcoma; Prognosis; Survival Rate | 1990 |
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli Experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial ci
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate | 1990 |
The importance of dose-intensity in neoadjuvant chemotherapy of osteosarcoma: a retrospective analysis of high-dose methotrexate, cisplatinum and adriamycin used preoperatively.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Protocols; Colorectal Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Humans; Leg; Male; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies | 1990 |
Massive pulmonary tumor emboli in osteosarcoma. Occult and fatal complication.
Topics: Adolescent; Doxorubicin; Female; Femoral Neoplasms; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Pulmonary Embolism | 1990 |
Do visual evoked potentials detect neural damage in children treated for cancer?
Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy | 1990 |
[The results of using high-dose methotrexate in treating osteogenic sarcoma].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Drug Evaluation; Female; Femoral Neoplasms; Humans; Humerus; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care; Tibia | 1990 |
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.
Topics: Adolescent; Combined Modality Therapy; Encephalocele; Eye Neoplasms; Female; Humans; Infusions, Intravenous; Intracranial Pressure; Methotrexate; Necrosis; Neoplasms, Multiple Primary; Neoplasms, Radiation-Induced; Orbital Neoplasms; Osteosarcoma; Retinoblastoma | 1990 |
[Successful treatment of several metachronous pulmonary metastases of a chondroblastic osteosarcoma].
Topics: Amputation, Surgical; Bleomycin; Child; Chondroblastoma; Cyclophosphamide; Dactinomycin; Female; Humans; Ifosfamide; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Tibia | 1985 |
The angiographic response of osteosarcoma following pre-operative chemotherapy.
Topics: Adolescent; Adult; Angiography; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Preoperative Care; Vincristine | 1986 |
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1986 |
Neoadjuvant chemotherapy for osteogenic sarcoma: a model for the treatment of other highly malignant neoplasms.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma | 1986 |
Disparate histologic responses in simultaneously resected primary and metastatic osteosarcoma following intravenous neoadjuvant chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Necrosis; Osteosarcoma; Postoperative Care; Preoperative Care; Vincristine | 1987 |
Translocation t(9;11)(p21;q23) with acute myelomonocytic leukemia after chemotherapy for osteosarcoma: good response to antileukemic drugs.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 9; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma; Translocation, Genetic | 1987 |
[The reproduction in France of Rosen's protocol for osteosarcomas].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis | 1988 |
[Experience with protocol T10 in the pediatric service at the Gustave-Roussy Institute].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Prognosis | 1988 |
[Preoperative systemic chemotherapy of patients with osteosarcoma: a preliminary study of nine cases].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Male; Methotrexate; Osteosarcoma; Premedication | 1989 |
[Mirror-image osteosarcoma of the radius. A case].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma; Prognosis; Radius | 1989 |
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities.
Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Arm; Bleomycin; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Follow-Up Studies; Humans; Leg; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Premedication | 1989 |
Secondary cerebral astrocytoma 3 years after diagnosis of primary osteogenic sarcoma: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bleomycin; Brain Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Electroencephalography; Femoral Neoplasms; Humans; Male; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma | 1987 |
Methotrexate clearance and clinical toxicity in osteosarcoma following high-dose methotrexate therapy.
Topics: Adolescent; Adult; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma | 1989 |
[Massive bone allografts in large bone defects after tumor surgery: a clinical long-term study].
Topics: Bone Neoplasms; Bone Transplantation; Chondrosarcoma; Combined Modality Therapy; Doxorubicin; Femoral Neoplasms; Histiocytoma, Benign Fibrous; Humans; Methotrexate; Osteosarcoma; Postoperative Period; Sarcoma; Tibia | 1989 |
Methotrexate diffusion from acrylic cement. Local chemotherapy for bone tumours.
Topics: Animals; Bone Cements; Bone Neoplasms; Diffusion; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Implants; In Vitro Techniques; Methotrexate; Methylmethacrylates; Osteosarcoma; Rats; Time Factors | 1989 |
[Spontaneous pneumothorax in patients with osteosarcoma treated by combined chemotherapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Doxorubicin; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pneumothorax; Time Factors; Vincristine | 1989 |
[Individualization of the dosage of high-dose methotrexate by assaying plasma concentration. Therapeutic value in osteogenic sarcoma].
Topics: Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Osteosarcoma; Time Factors | 1989 |
Resistance to methotrexate and multidrug resistance in childhood malignancies.
Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Child; DNA, Neoplasm; Drug Resistance; Female; Humans; Infant; Leukemia; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1989 |
Overall results of adjuvant chemotherapy and a chemosensitivity test for osteosarcoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Time Factors; Tumor Stem Cell Assay; Vincristine | 1989 |
Drug resistance and cross-sensitivity in cultured human osteosarcoma cells.
Topics: Cisplatin; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Methotrexate; Osteosarcoma; Tumor Cells, Cultured; Vincristine | 1989 |
Daily profiles of plasma phenylalanine and tyrosine in patients with osteogenic sarcoma during treatment with high-dose methotrexate-citrovorum rescue.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine | 1989 |
[Management of the administration of leucovorin calcium in high-dose methotrexate therapy].
Topics: Adult; Blood Cell Count; Bone Neoplasms; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1989 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Removal of methotrexate by hemodiafiltration.
Topics: Hemofiltration; Humans; Male; Mandibular Neoplasms; Methotrexate; Middle Aged; Osteosarcoma; Renal Dialysis | 1989 |
Magnetic resonance imaging (MRI) in evaluating in vivo response to neoadjuvant chemotherapy for osteosarcomas of the extremities.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Female; Femur; Humans; Humerus; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Prospective Studies; Tibia; Tomography, X-Ray Computed | 1989 |
MR findings in methotrexate-induced CNS abnormalities.
Topics: Adolescent; Adult; Brain; Brain Diseases; Child; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma | 1989 |
The current management of malignant bone tumours: where do we go from here?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Histiocytoma, Benign Fibrous; Humans; Methotrexate; Osteosarcoma; Sarcoma, Ewing | 1988 |
Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen.
Topics: Adolescent; Adult; Aged; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ketoprofen; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Osteosarcoma; Phenylpropionates; Retrospective Studies; Time Factors | 1986 |
Folinic acid rescue and methotrexate toxicity.
Topics: Acute Kidney Injury; Adolescent; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma | 1986 |
Enhancement of methotrexate nephrotoxicity after cisplatin therapy.
Topics: Acetylglucosaminidase; Adolescent; Adult; Aminopeptidases; Antineoplastic Combined Chemotherapy Protocols; Carrier Proteins; CD13 Antigens; Cisplatin; Dipeptidyl Peptidase 4; Humans; Kidney Tubules; Methotrexate; Osteosarcoma; Prospective Studies; Proteinuria | 1986 |
Perioperative chemotherapy for primary sarcoma of bone.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Intraoperative Care; Male; Methotrexate; Osteosarcoma; Premedication; Vincristine | 1989 |
[Treatment of osteogenic sarcoma].
Topics: Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Hip Prosthesis; Humans; Joint Prosthesis; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis | 1989 |
[Osteogenic osteosarcoma, a model of a disease that is curable using a multidisciplinary treatment approach].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma; Prostheses and Implants | 1988 |
Breast cancer after treatment for osteosarcoma.
Topics: Adenocarcinoma; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Lymph Node Excision; Lymphatic Metastasis; Mastectomy; Methotrexate; Osteosarcoma; Risk | 1986 |
Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pentosyltransferases; Thymidine | 1987 |
Blood-brain barrier disruption and methotrexate in the treatment of a readily transplantable intracerebral osteogenic sarcoma of rats.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carotid Arteries; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Mannitol; Methotrexate; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Inbred Strains | 1987 |
Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two alternating drug combinations and early prophylactic lung irradiation. French Bone Tumor Study Group.
Topics: Adolescent; Adult; Aging; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; Femoral Neoplasms; Fibula; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Mitomycin; Mitomycins; Osteosarcoma; Prognosis; Radiotherapy Dosage; Tibia; Time Factors; Vincristine | 1988 |
[Angiographic evaluation of the response of osteosarcoma to neoadjuvant chemotherapy].
Topics: Adolescent; Angiography; Bone Neoplasms; Cisplatin; Female; Humans; Male; Methotrexate; Osteosarcoma | 1988 |
[Experience with Rosen's T10 protocol at the Oscar Lambret Center (Lille) from 1982 to 1985. Apropos of 13 cases of non-metastatic osteosarcomas of the extremities].
Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Female; Femoral Neoplasms; Humans; Humerus; Male; Methotrexate; Osteosarcoma; Radius; Tibia | 1988 |
[Chemotherapy of sarcomas in the adult].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine | 1988 |
Neoadjuvant chemotherapy for osteosarcoma of the extremities. Good response of the primary tumor after preoperative chemotherapy with high-dose methotrexate followed by cisplatinum and adriamycin. Preliminary results.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma | 1988 |
Importance of age and methotrexate dosage: prognosis in children and young adults with high-grade osteosarcomas.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Prognosis | 1988 |
The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Prognosis | 1988 |
The effects of methotrexate (MTX) on bone. A densitometric study conducted on 59 patients with MTX administered at different doses.
Topics: Adolescent; Adult; Bone and Bones; Bone Neoplasms; Child; Densitometry; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Minerals; Osteosarcoma | 1988 |
Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities: preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Random Allocation; Time Factors | 1988 |
Renal insufficiency in patients treated with high dose methotrexate.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Combined Modality Therapy; Drug Interactions; Female; Humans; Iopamidol; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Osteosarcoma | 1988 |
Methotrexate administered by 6-h and 24-h infusion: a pharmacokinetic comparison.
Topics: Child; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma | 1988 |
Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion.
Topics: Adolescent; Female; Hemoperfusion; Humans; Leucovorin; Methotrexate; Osteosarcoma; Renal Dialysis; Tetrahydrofolates | 1988 |
[High-dose methotrexate with citrovorum factor rescue (HD-MTX-CFR) in the treatment of malignant solid tumors--clinical analysis of 62 patients].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; Humans; Leucovorin; Lung Neoplasms; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma | 1988 |
[Postoperative adjuvant chemotherapy of high dose MTX for osteogenic sarcoma].
Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Combined Modality Therapy; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Postoperative Care; Retrospective Studies; Tibia | 1988 |
Combined chemotherapy and surgery for pulmonary metastases from osteogenic sarcoma. Results of 10 years experience.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Prospective Studies; Recurrence; Survival Rate | 1988 |
[Autologous bone marrow transplantation in osteosarcoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Transplantation, Autologous | 1987 |
[Clinical effect of prostaglandin E1 on liver dysfunction due to high-dose methotrexate].
Topics: Alprostadil; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Osteosarcoma | 1988 |
Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
Topics: Child; Chromatography, High Pressure Liquid; Humans; Kinetics; Methotrexate; Osteosarcoma; Time Factors | 1986 |
An improved synthesis of a methotrexate-albumin-791T/36 monoclonal antibody conjugate cytotoxic to human osteogenic sarcoma cell lines.
Topics: Antibodies, Monoclonal; Cell Survival; Cells, Cultured; Humans; Hydrogen-Ion Concentration; Immunochemistry; Methotrexate; Osteosarcoma; Selenomethionine; Serum Albumin | 1986 |
Methotrexate interferes with determinations of conjugated bilirubin with the Kodak Ektachem 400.
Topics: Autoanalysis; Bilirubin; False Positive Reactions; Humans; Methotrexate; Osteosarcoma; Spectrophotometry | 1986 |
Phase II study of low-dose methotrexate in advanced osteosarcoma followed by escalation after disease progression: a study of the Soft Tissue and Bone Sarcoma Group of the European Organization for Research on Treatment of Cancer.
Topics: Adolescent; Adult; Bone Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Osteosarcoma; Random Allocation; Time Factors | 1986 |
Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: is a good response to preoperative treatment an indication to reduce postoperative chemotherapy?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Extremities; Female; Femoral Neoplasms; Fibula; Humans; Humerus; Infant; Infant, Newborn; Infusions, Intra-Arterial; Injections, Intravenous; Male; Methotrexate; Necrosis; Osteosarcoma; Postoperative Care; Preoperative Care; Tibia; Time Factors | 1986 |
Targeting of anti-cancer therapeutic agents by monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cisplatin; Daunorubicin; Dosage Forms; Doxorubicin; Methotrexate; Mice; Osteosarcoma; Serum Albumin; Vindesine | 1986 |
The influence of high-dose methotrexate therapy on serum iron.
Topics: Adolescent; Adult; Bone Neoplasms; Dose-Response Relationship, Drug; Erythropoiesis; Female; Humans; Iron; Male; Methotrexate; Middle Aged; Osteosarcoma | 1986 |
[Surgery and adjuvant chemotherapy of osteosarcoma].
Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care | 1986 |
Leukocytoclastic vasculitis after high-dose methotrexate.
Topics: Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Vasculitis | 1986 |
Chemosensitivity testing with tumor colony-forming assay for human osteosarcoma.
Topics: Aclarubicin; Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Colony-Forming Units Assay; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Naphthacenes; Osteosarcoma; Vincristine | 1986 |
[In vivo 31P-NMR studies on energy metabolism and the effect of methotrexate in murine implanted osteosarcoma].
Topics: Animals; Drug Evaluation, Preclinical; Energy Metabolism; Female; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma | 1986 |
Transient cerebral dysfunction secondary to high-dose methotrexate.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Brain Diseases; Electroencephalography; Female; Glioma; Hodgkin Disease; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Paresis; Seizures; Syndrome | 1986 |
[Results of the treatment of osteosarcoma at the National Children's Hospital of Costa Rica].
Topics: Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Costa Rica; Cyclophosphamide; Disarticulation; Doxorubicin; Female; Humans; Injections, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis; Vincristine | 1986 |
Neoadjuvant high-dose methotrexate, cisplatin, and doxorubicin for the management of patients with nonmetastatic osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma | 1986 |
Conjugates of monoclonal antibody 791T/36 with methotrexate in cancer therapy.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Evaluation Studies as Topic; Flow Cytometry; Humans; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Serum Albumin; Tumor Stem Cell Assay | 1987 |
Renal toxicity with cumulative doses of cis-diamminedichloroplatinum-II in pediatric patients with osteosarcoma. Effect on creatinine clearance and methotrexate excretion.
Topics: Child; Cisplatin; Creatine; Dose-Response Relationship, Drug; Humans; Kidney Diseases; Methotrexate; Osteosarcoma | 1987 |
Continuous cisplatin infusion in combination with vincristine and high-dose methotrexate for advanced osteogenic sarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Humans; Infusions, Intravenous; Lymphatic Metastasis; Methotrexate; Osteosarcoma; Time Factors; Vincristine | 1987 |
Cerebellar sclerosis in pediatric cancer patients.
Topics: Cerebellum; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Retrospective Studies; Sclerosis | 1987 |
Urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations predict impaired excretion of methotrexate.
Topics: Acetylglucosaminidase; Adolescent; Adult; Child; Cisplatin; Creatinine; Half-Life; Hexosaminidases; Humans; Kidney Diseases; Methotrexate; Osteosarcoma | 1987 |
[Rationale of preoperative chemotherapy of osteosarcoma].
Topics: Adult; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Preoperative Care | 1987 |
[Limb salvage in osteosarcoma. Significance of preoperative isolation perfusion chemotherapy].
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Hyperthermia, Induced; Male; Methotrexate; Middle Aged; Osteosarcoma; Preoperative Care; Prognosis | 1987 |
Doxorubicin and methotrexate on a weekly schedule in patients with sarcomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Schedule; Female; Fibrosarcoma; Humans; Leiomyosarcoma; Liposarcoma; Male; Methotrexate; Middle Aged; Neurofibroma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Time Factors | 1987 |
Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's Hospital--study III.
Topics: Actuarial Analysis; Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Prognosis | 1987 |
Methotrexate test-dose protocol in the presence of 7-hydroxy-methotrexate.
Topics: Adolescent; Adult; Aged; Child; Head and Neck Neoplasms; Humans; Hydroxylation; Infusions, Intravenous; Injections, Intravenous; Methotrexate; Middle Aged; Osteosarcoma | 1987 |
[Bone cement containing cytostatic drugs: new aspects in the treatment of malignant bone tumors. I. Experimental studies].
Topics: Animals; Bone and Bones; Bone Cements; Bone Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Methylmethacrylate; Methylmethacrylates; Mice; Neoplasm Transplantation; Osteosarcoma | 1987 |
[Methotrexate poisoning: value of exchange transfusion].
Topics: Acute Kidney Injury; Child; Exchange Transfusion, Whole Blood; Humans; Leukopenia; Male; Methotrexate; Osteosarcoma; Thrombocytopenia | 1987 |
[Early discovery and nursing of adverse effects associated with administration of massive dosages of MTX].
Topics: Adolescent; Bone Neoplasms; Humans; Male; Medication Errors; Methotrexate; Osteosarcoma | 1987 |
[Experimental study on osteosarcoma of local chemotherapy diffusing from surgical acrylic cement and plaster].
Topics: Animals; Antineoplastic Agents; Bone Cements; Casts, Surgical; Cisplatin; Dogs; Doxorubicin; Drug Implants; Humans; Methacrylates; Methotrexate; Osteosarcoma; Rats; Research Design; Sarcoma, Experimental | 1987 |
[Osteosarcoma of the leg; treatment results following preoperative chemotherapy].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Postoperative Care; Premedication | 1986 |
[Neo-adjuvant therapy in childhood osteogenic sarcoma: a pilot study of selective postoperative chemotherapy based on response to preoperative high-dose methotrexate].
Topics: Adjuvants, Immunologic; Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Pilot Projects; Preoperative Care | 1986 |
Sensitivity and selectivity of ricin toxin A chain-monoclonal antibody 791T/36 conjugates against human tumor cell lines.
Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Binding, Competitive; Cell Line; Cell Survival; Humans; Immunotoxins; Methotrexate; Osteosarcoma; Ricin; Time Factors | 1986 |
Experimental studies on high-dose methotrexate with citrovorum factor chemotherapy for 89Sr-induced osteosarcoma murine model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Injections, Intraperitoneal; Injections, Intravenous; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Osteosarcoma; Strontium Radioisotopes | 1986 |
Pathologic fracture in osteosarcoma. Impact of chemotherapy on primary tumor and survival.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Fractures, Spontaneous; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma | 1987 |
[Spectral EEG analysis in children treated with high-dose methotrexate].
Topics: Bone Neoplasms; Child; Child, Preschool; Electroencephalography; Female; Humans; Infusions, Intravenous; Leucovorin; Lymphoma; Male; Methotrexate; Osteosarcoma | 1987 |
[Significance of surgical adjuvant chemotherapy in osteosarcoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Postoperative Care | 1987 |
[Compatibility and toxicity of methotrexate in the treatment of bone tumors].
Topics: Bone Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma | 1987 |
High-dose methotrexate therapy with leucovorin rescue: in vitro investigations on human osteosarcoma cell lines.
Topics: Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Humans; Leucovorin; Methotrexate; Osteosarcoma; Thymidine; Tumor Cells, Cultured | 1987 |
7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy.
Topics: Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans; Methotrexate; Osteosarcoma; Time Factors | 1985 |
Dosage predictions in high-dose methotrexate infusions. Part 1: Evaluation of the classic test-dose protocol.
Topics: Head and Neck Neoplasms; Humans; Kinetics; Mathematics; Methotrexate; Osteosarcoma; Sarcoma; Time Factors | 1985 |
Primary osteogenic sarcoma of the skull. Five-year disease-free survival following surgery and high dose methotrexate therapy.
Topics: Female; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Skull Neoplasms | 1985 |
[Delayed excretion of high doses of methotrexate].
Topics: Adolescent; Dose-Response Relationship, Drug; Humans; Kidney; Male; Methotrexate; Osteosarcoma | 1985 |
Response of osteosarcoma to preoperative intravenous high-dose methotrexate chemotherapy: CT evaluation.
Topics: Adolescent; Amputation, Surgical; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Extremities; Female; Humans; Injections, Intravenous; Male; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 1985 |
Control of primary osteosarcoma with chemotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Ilium; Infusions, Intra-Arterial; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Tibia | 1985 |
Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.
Topics: Adolescent; Adult; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Child; Humans; Kinetics; Leucovorin; Methotrexate; Osteosarcoma; Retrospective Studies | 1985 |
Transient neurologic disturbances induced by high-dose methotrexate treatment.
Topics: Bone Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma | 1985 |
[Clinical significance of non-renal elimination mechanisms of methotrexate (MTX)].
Topics: Abdominal Neoplasms; Adolescent; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bile; Child; Child, Preschool; Cholestyramine Resin; Chromatography, High Pressure Liquid; Enterohepatic Circulation; Female; Femoral Neoplasms; Humans; Kinetics; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma | 1985 |
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors.
Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fibrosarcoma; Fluorouracil; Humans; Leiomyosarcoma; Male; Melanoma; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Pancreatic Neoplasms; Pharyngeal Neoplasms; Prognosis; Sarcoma; Sarcoma, Synovial; Vincristine | 1969 |
The use of oral methotrexate (mtx) in the treatment of tumours in the head and neck-region.
Topics: Adenocarcinoma; Administration, Oral; Aged; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cystadenoma; Ear Neoplasms; Female; Head; Head and Neck Neoplasms; HeLa Cells; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Osteosarcoma | 1970 |
Blood and neoplastic diseases. Solid tumours in children.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Diagnosis, Differential; Doxorubicin; Hodgkin Disease; Humans; Infant; Methods; Methotrexate; Neoplasms; Neuroblastoma; Nitrogen Mustard Compounds; Osteosarcoma; Prednisolone; Prognosis; Radiography; Retinoblastoma; Rhabdomyosarcoma; Sarcoma, Ewing; Vincristine; Wilms Tumor | 1974 |
Recent advances in the chemotherapy of metastatic osteogenic sarcoma.
Topics: Adolescent; Adult; Child; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1972 |
Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy.
Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Kidney; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Skin; Stomatitis | 1973 |
High-dose methotrexate with citrovorum factor rescue and adriamycin in childhood osteogenic sarcoma.
Topics: Adolescent; Age Factors; Alkaline Phosphatase; Aspartate Aminotransferases; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Hematopoietic System; Humans; Leucovorin; Male; Methotrexate; Mucous Membrane; Nausea; Neoplasm Metastasis; Osteosarcoma | 1974 |
Editorial: A giant step forward - if....
Topics: Amputation, Surgical; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma | 1974 |
Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-"leucovorin rescue" for children with malignant tumors.
Topics: Adolescent; Age Factors; Aspartate Aminotransferases; Child; Child, Preschool; Female; Half-Life; Hematopoiesis; Humans; Kidney; Leucovorin; Liposarcoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Rhabdomyosarcoma; Sarcoma, Ewing; Teratoma | 1974 |
Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.
Topics: Antineoplastic Agents; Brachial Artery; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Artery, Internal; Catheterization; Cyclophosphamide; Dactinomycin; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Melanoma; Methods; Methotrexate; Mouth Neoplasms; Neoplasms; Osteosarcoma; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms; Skull Neoplasms; Vinblastine | 1972 |
[A new combination of methotrexate and folinic acid for cancer treatment (acute leukemia and solid tumors)].
Topics: Agranulocytosis; Antineoplastic Agents; Breast Neoplasms; Female; Hemangiosarcoma; Hodgkin Disease; Humans; Kidney Neoplasms; Leucovorin; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Osteosarcoma; Pancreatic Neoplasms; Radiography; Rectal Neoplasms; Rhabdomyosarcoma; Testicular Neoplasms; Thrombocytopenia | 1969 |
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Ethylenediamines; Facial Neoplasms; Fibrosarcoma; Glioma; Humans; Infusions, Parenteral; Mechlorethamine; Melanoma; Melphalan; Meningioma; Methotrexate; Osteosarcoma; Perfusion; Quinones; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Thiotepa | 1967 |