Page last updated: 2024-08-25

methotrexate and Osteogenic Sarcoma

methotrexate has been researched along with Osteogenic Sarcoma in 916 studies

Research

Studies (916)

TimeframeStudies, this research(%)All Research%
pre-1990372 (40.61)18.7374
1990's174 (19.00)18.2507
2000's149 (16.27)29.6817
2010's176 (19.21)24.3611
2020's45 (4.91)2.80

Authors

AuthorsStudies
Chen, X; Deng, Y; Li, Y; Li, Z; Wei, D; Xiang, F; Xu, Y1
Bajpai, J; Banavali, SD; Khan, SA; Kumar, VS; Mailankody, S1
Aoki, Y; Bouvet, M; Hamada, K; Han, Q; Hoffman, RM; Kubota, Y; Masaki, N; Nishida, K; Tome, Y; Yamamoto, J1
Abe, K; Furukawa, T; Hashimoto, H; Ishizu, T; Iwata, S; Kawano, Y; Kobayashi, E; Maeda-Minami, A; Mano, Y; Miyazaki, S; Shimoi, T; Yamaguchi, M1
De Pinieux, G; Le Nail, LR; Narciso, B; Salaün, H; Simon, C; Vegas, H; Vinceneux, A1
Alcasabas, AP; Blair, S; Dhamne, C; Lam, C; Leung, KWP; Loh, AHP; Monsereenusorn, C; Oh, BLZ; Photia, A; Puhaindran, ME; Rodriguez-Galindo, C; Rujkijyanont, P; Soh, SY; Traivaree, C; Veerapan, P; Wang, E1
Alemi, F; Farsad-Akhtar, N; Malakoti, F; Maleki, M; Mohammadi, E; Yousefi, B1
Majidinia, M; Malakoti, F; Sanapour, N; Shanebandi, D; Soleimanpour, J; Targhazeh, N; Yousefi, B1
Cheng, H; Ran, S; Shao, C; Sun, W; Wan, Y; Yin, X; Zhang, M; Zhu, Z1
Elhasid, R; Levin, D; Manisterski, M; Peled, Y; Shiran, S; Shukrun, R1
Chekhonin, VP; Li, H; Li, S; Li, Z; Lin, Y; Ma, W; Peltzer, K; Wang, J; Wang, X; Wu, H; Xu, G; Xu, Y; Xue, Y; Zhang, C; Zhang, J1
Khyavi, PA; Shanehbandi, D; Soleimanpour, J; Valizadeh, A; Yousefi, B1
Bielack, SS; Blattmann, C; Borkhardt, A; Csóka, M; Hassenpflug, W; Hecker-Nolting, S; Kabíčková, E; Kager, L; Kessler, T; Kevric, M; Kratz, C; Kühne, T; Lehrnbecher, T; Mayer-Steinacker, R; Mettmann, V; Metzler, M; Reichardt, P; Rossig, C; Sorg, B; von Luettichau, I; Windhager, R1
Gomes, CMF; Martins-Neves, SR; Sampaio-Ribeiro, G1
Hills, F; Low, K; Roberts, HC; Stordal, B1
An, HY; Bai, B; Sun, MX; Sun, YB1
Cohen, IJ; Sadeh, M; Toledano, H1
Fu, D1
Hashida, N; Isshiki, K; Sakai, M; Sato, S; Shima, H; Shimada, H; Takimoto, T1
Chen, G; Ji, C; Li, J; Li, M; Long, Z; Lu, Y; Wang, Q; Wang, Z; Xiang, L; Yu, H1
Chang, YL; Chen, WM; Chou, YC; Huang, KW; Hung, GY; Lee, HC; Wang, SF; Wu, PK1
Mehrvar, A; Mehrvar, N; Sadeghi, Y; Tashvighi, M1
Ishizaki, J; Kitagawa, K; Nakano, C; Sai, Y; Suga, Y1
Bernhardt, MB; Cheng, WS; Foster, JH; Rainusso, N; Wang, LL; Young, EP1
Li, J; Li, R; Lu, X; Zhang, B; Zhang, Y1
Jayakrishnan, A; Kumar, TSS; Prasad, SR2
Fujiwara, T; Jeys, LM; Parry, MC; Stevenson, JD; Sumathi, V; Tsoi, K; Tsuda, Y1
Li, X; Liu, Y; Shen, J; Xu, R; Yu, X; Zhang, X1
Aguado, L; Gutiérrez, M; Idoate, MÁ; Moreno-Artero, E; Querol-Cisneros, E; Rodríguez-Garijo, N; Tomás-Velázquez, A1
Alemi, F; Asemi, Z; Bazavar, M; Fazli, J; Ma, B; Maleki, M; Mohammadi, E; Valizadeh, A; Xing, S; Yousefi, B1
Bao, Q; Cheng, J; Han, J; Hu, Y; Liu, X; Song, R; Wang, W; Wang, Z; Wu, S; Yao, Y; Yu, L; Yu, W; Yu, X; Yu, Y; Zhang, G; Zhang, W; Zhao, M1
Fried, M; Krämer, I; Kühn, M; Rosentreter, J1
Doval, DC; Jain, S; Kapoor, G; Sharma, P; Tripathi, R; Verma, P1
Duan, W; Ji, L; Wei, W; Zhu, J1
Anderson, PM; Gennatas, S; Gulia, A; Huang, PH; Jones, RL; Smrke, A1
Abe, K; Araki, Y; Asano, Y; Hayashi, K; Higuchi, T; Igarashi, K; Ikeda, H; Miwa, S; Morinaga, S; Nojima, T; Takeuchi, A; Taniguchi, Y; Tsuchiya, H; Yamamoto, N; Yonezawa, H1
Cao, S; Hao, Y; Peng, C; Ren, Z; Zhang, P; Zhu, J1
Alemi, F; Asemi, Z; Golchin, A; Javadi, S; Khiavi, PA; Maleki, M; Soleinmapour, J; Younesi, S; Yousefi, B1
Xiang, RM; Yan, JP1
Demir, B; Demir, E; Sütcüoğlu, O; Ünsal, O; Yazıcı, O1
Hiraga, H; Ozaki, T1
Chen, F; Chen, J; Gong, Y; Li, X; Luo, L; Ma, Y; Shi, C; Sun, Y; Wang, L; Xu, Z1
Guruprasad, CS; Nair, M; Prasanth, VR; Rajeswari, B; Sugath, BS; Thankamony, P1
Le, T; Shahriyari, L; Su, S1
Arana, S; Blanco-Prieto, MJ; Errazquin-Irigoyen, M; González-Fernández, Y; Hisey, CL; Imbuluzqueta, E; Mitxelena-Iribarren, O; Mujika, M1
Gehrs, BC; Meyer, WH; Palacios, MF; Pokala, HR; Pratap, S1
Li, S; Xiong, Y; Zhang, X1
Holt, GE; Lipshultz, ER; Lipshultz, SE; Ramasamy, R; Yechieli, R1
Dhooge, C; Labarque, V; Laenen, A; Lambrecht, L; Renard, M; Sinnaeve, F; Sleurs, C; Uyttebroeck, A1
da Motta Girardi, D; da Silva Rocha, LS; Feher, O; Negrão, MV1
Bahrami, A; Billups, CA; Daryani, VM; Daw, NC; Kunkel, M; Loeb, DM; Mao, S; McCarville, MB; Navid, F; Neel, M; Pappo, AS; Rao, BN; Reikes Willert, J; Santana, VM; Shulkin, BL; Smith, W; Stewart, CF; Ward, D; Wu, J1
Meshkini, A; Oveisi, H1
Deng, ZP; Ding, Y; Jin, T; Li, B; Liu, BY; Niu, XH; Sun, Y1
Bajpai, J; Banavali, SD; Chandrakanth, MV; Chandrasekharan, A; Ghosh, J; Gupta, S; Khan, A; Khurana, S; Rekhi, B; Simha, V; Talreja, V; Vora, T1
Gupta, A; Hopyan, S; Koo, A; Renzi, S; Taylor, T; Tsimerman, E1
Avan, A; de Sá Lopes, AC; Dos Santos Cavalcanti, A; Gholamin, S; Hanae Kasai Brunswick, T; Kahn, SA; Leite Duarte, ME; Matheus Guimarães, JA; Meohas, W; Razavi, M; Ribeiro, GO1
Cacciavillano, W; Rose, A; Scopinaro, M; Villegas Rubio, JA; Zubizarreta, P1
Fang, GW; Liu, W; Xue, Y; Zhang, YJ; Zhao, X1
Han, Z; Shi, L1
Bompas, E; Bouvier, C; Brisse, HJ; Brugieres, L; Castex, MP; Cheurfa, N; Corradini, N; Delaye, J; Entz-Werlé, N; Gaspar, N; Gentet, JC; Italiano, A; Le Deley, MC; Lervat, C; Marec-Berard, P; Mascard, E; Occean, BV; Pacquement, H; Piperno-Neumann, S; Redini, F; Saumet, L; Schmitt, C; Tabone, MD; Verite-Goulard, C1
Altaf, S; Broomall, E; Cooper, J; Hogan, MC; Khan, S; Rodriguez, V; Scott, K; Wyatt, KD1
Bagatell, R; Balamuth, N; Balis, F; Fox, E; Levin, K; Segers, B; Womer, R; Zhu, Y1
Collier, CD; Getty, PJ; Greenfield, EM; Knafler, GJ; Morris, WZ; Wirtz, EC1
Bai, J; Cui, Y; Ding, L; Han, X; Li, R; Wang, C; Zhou, Y1
Nath, A; Sims, E; Sugalski, A1
Bernardino, PN; Bersano, PRO; Lima Neto, JF; Sforcin, JM1
Bouazza, N; Brugieres, L; Corradini, N; Entz-Werle, N; Fresneau, B; Freycon, C; Gaspar, N; Gentet, JC; Laurence, V; Le Deley, MC; Le Teuff, G; Lervat, C; Lui, G; Mahier Ait Oukhatar, C; Marec Berard, P; Millot, F; Pacquement, H; Piperno-Neumann, S; Schneider, P; Taque, S; Treluyer, JM1
Kawai, A; Kobayashi, H; Ogura, K; Shinoda, Y; Tanaka, S; Tsuda, Y1
Berber, M; Dincaslan, H; Incesoy Ozdemir, S; Tacyildiz, N; Unal, E; Yavuz, G1
Grant, R; Gupta, AA; Hendershot, E; Mills, D; Nicksy, D; Ramachandran, N; Riss, V; Shaikh, F; Taylor, T; Volpe, J1
Barceló, B; Berga, F; Costa-Bauza, A; Elorza, MÁ; Gimenez, S; Gomila, I; Grases, F; Luna, P; Martorell, C; Rey, J; Sánchez, I1
Bajpai, J; Banavali, S; Chandrasekharan, A; Ghosh, J; Gupta, S; Karpe, A; Pandey, N; Rekhi, B; Simha, V; Singh, A; Talreja, V; Vora, T1
Li, Z; Xu, R; Xu, W; Xu, Y; Zhu, X1
Cheng, WTF; Chu, HM; Fong, PS; Hui, KH; Lam, TN1
Bubalo, J; Dang, T; Davis, LE; Fu, R; Gundle, KR; Paxton, J; Ryan, CW; Stork, L; Wippel, B1
Anninga, J; Antal, I; Arndt, C; Bernstein, M; Bielack, SS; Brown, KLB; Butterfass-Bahloul, T; Calaminus, G; Capra, M; Dhooge, C; Eriksson, M; Flanagan, AM; Friedel, G; Gebhardt, MC; Gelderblom, H; Goldsby, R; Gorlick, R; Grier, HE; Grimer, R; Hawkins, DS; Hecker-Nolting, S; Hogendoorn, P; Ingleby, FC; Isakoff, MS; Janeway, KA; Jovic, G; Kabickova, E; Kager, L; Krailo, MD; Kühne, T; Lang, S; Lau, CC; Leavey, PJ; Lessnick, SL; Marina, N; Mascarenhas, L; Mayer-Steinacker, R; Meyers, PA; Nagarajan, R; Randall, RL; Rechnitzer, C; Reichardt, P; Renard, M; Schwartz, CL; Smeland, S; Strauss, S; Sundby Hall, K; Sydes, MR; Teot, L; Timmermann, B; von Kalle, T; Whelan, J1
Bao, S; Chan, ACL; Chan, JKC; Lau, GTC; Yau, DTW; Zheng, Z1
Gao, HD; Hou, ZL; Tang, QX; Wang, LC; Wang, Y1
Chen, P; Li, S; Pei, Y; Qiu, E; Wang, W; Zhang, X; Zheng, K1
He, A; Hu, H; Lin, F; Min, D; Shen, Z; Tang, L; Yu, W; Zheng, S1
Abboud, MR; Abou Ali, B; Akel, S; Boulos, F; El-Solh, H; Ghanem, KM; Haidar, R; Muwakkit, SA; Saab, R; Saghieh, S; Salman, M; Tamim, H1
Feng, A; Han, C; Liu, R; Lv, Y; Mao, Y; Tian, Y; Xu, D; Yu, D; Zhang, S; Zhao, Y; Zhu, Q1
de Haan, J; Oude Munnink, T; Touw, D; van der Meer, A; van Kruchten, M1
Anract, P; Bertucci, F; Blay, JY; Bompas, E; Brugieres, L; Collard, O; Cupissol, D; de Pinieux, G; Delaye, J; Duffaud, F; Italiano, A; Laurence, V; Le Cesne, A; Le Deley, MC; Occean, BV; Penel, N; Perrin, C; Piperno-Neumann, S; Ray-Coquard, I; Rios, M1
Aoki, Y; Araki, N; Hashimoto, N; Ieguchi, M; Kudawara, I; Kuratsu, S; Matsumine, A; Mori, S; Myoui, A; Naka, N; Nakanishi, H; Ueda, T; Yoshikawa, H1
Asadi, N; Bini, A; Caroli, G; Dell'Amore, A; Dolci, G; Stella, F1
Bi, W; Han, G; Jia, J; Wang, W; Xu, M1
Arush, MW; Ash, S; Bonda-Shkedi, E; Cohen, IJ; Goshen, Y; Kaplinsky, C; Yaniv, I1
Charoenkwan, P; Choeyprasert, W; Natesirinilkul, R; Sittipreechacharn, S1
Byun, BH; Cho, WH; Choi, CW; Jeon, DG; Koh, JS; Kong, CB; Lee, SY; Lim, I; Lim, SM; Song, WS1
Hou, WG; Liu, Y; Ma, C; Sun, XH; Zhao, HX; Zhao, YL1
Asprodini, E; Begas, E; Daliani, D; Papandreou, C; Papatsibas, G; Tsakalof, A1
Golovko, TS; Gulak, LO; Kobys, VL; Konovalenko, VF; Matyushok, OF; Repinа, NV; Tarasova, TO; Zaharycheva, EV1
Bai, SB; Bao, YX; Chen, HX; Luo, X; Zhong, JJ1
Bienemann, K; Hanenberg, H; Howe, SJ; Kramm, CM; Sena-Esteves, M; Staege, MS1
Crews, KR; Navid, F; Panetta, JC; Scott, JR; Ward, DA1
Cai, HQ; Li, YC; Wang, ZG; Xu, YL; Yang, J1
Chauhan, N; Christensen, R; Daugherty, C; Howard, SC; Jayaprakash, N; King, TR; Pui, CH; Rush, JE; Schwartz, S; Widemann, BC1
Li, JM; Li, X; Li, YG; Si, M; Tian, JG; Zhao, J1
Boye, K; Del Prever, AB; Eriksson, M; Fagioli, F; Ferrari, S; Hall, KS; Lindholm, P; Saeter, G; Skjeldal, S; Tienghi, A1
Bain, E; Birhiray, RE; Reeves, DJ1
Bisogno, G; Marzollo, A1
Bruneau, B; Chappé, C; Gandemer, V; Robert, G; Taque, S1
Bar-Sela, G; Miller, RC; Novotny, PJ; Sio, TT; Sohawon, S; Thariat, J; Van Houtte, P; Vu, CC1
Li, B; Li, H; Li, Y; Sun, L; Ye, Z; Zhang, J1
Diller, L; Duffey-Lind, E; Ebb, D; Grier, H; Kenney, LB; Sklar, CA1
Bickels, J; Flusser, G; Gortzak, Y; Issakov, J; Kolander, Y; Kushnir, I; Merimsky, O1
Fukuoka, N; Houchi, H; Kosaka, S; Motoki, T; Takeuchi, T; Tanaka, H; Watanabe, M; Yamaguchi, K1
Jaffe, N9
Ellis, D; Necessary, CA; Roffwarg, D1
Chen, H; Chen, P; Duan, Z; He, W; Wang, H; Wang, J; Zou, JX1
Pei, FX; Song, YC; Yang, XN; Zeng, JC; Zhang, H1
Dolžan, V; Goričar, K; Jazbec, J; Kovač, V; Lamovec, J; Zakotnik, B1
Fu, WM; Hsieh, IS; Yang, RS1
Chang, WH; Chen, PC; Chen, WM; Chiou, HJ; Hsu, HE; Hung, GY; Wu, HT; Yen, CC; Yen, HJ1
Duarte, IF; Gil, AM; Lamego, I; Marques, MP1
Xu, M; Xu, S; Yu, X1
Wang, W; Wang, Z; Xiao, X1
Jiang, S; Lin, N; Liu, Y; Wang, Y; Xu, Y; Ye, Z1
Anninga, J; Bernstein, M; Bielack, SS; Böhling, T; Butterfass-Bahloul, T; Calaminus, G; Capra, M; Deffenbaugh, C; Dhooge, C; Eriksson, M; Flanagan, AM; Gelderblom, H; Goorin, A; Gorlick, R; Gosheger, G; Grimer, RJ; Hall, KS; Helmke, K; Hogendoorn, PC; Hook, JM; Jovic, G; Jundt, G; Kager, L; Krailo, M; Kuehne, T; Lau, CC; Letson, GD; Marina, N; Meyer, J; Meyers, PA; Morris, C; Mottl, H; Nadel, H; Nagarajan, R; Randall, RL; Schomberg, P; Schwarz, R; Smeland, S; Sydes, MR; Teot, LA; Whelan, JS1
Lao, L; Li, Q; Song, C; Zhang, W1
Lin, F; Shen, Z; Tang, L; Yao, Y; Yu, W1
Anurathapan, U; Choeyprasert, W; Chuansumrit, A; Hongeng, S; Nartthanarung, A; Pakakasama, S; Sirachainan, N; Songdej, D1
Lu, W; Niu, X; Tian, X; Zhang, Q; Zhang, W; Zhao, H; Zhen, J1
Mills, DK; Sun, L1
Benini, S; Ferrari, S; Gambarotti, M; Hattinger, CM; Magagnoli, G; Michelacci, F; Palmerini, E; Picci, P; Sella, F; Serra, M1
Cheng, C; Crews, KR; Jeha, S; Molinelli, AR; Navid, F; Relling, MV; Scott, JR; Stewart, CF; Swanson, HD; Ward, DA; Zhou, Y1
Kyr, M; Neradil, J; Pavlasova, G; Sramek, M; Sterba, J; Veselska, R1
Alnæs, GI; Andersen, AM; Hall, KS; Holmboe, L; Jabeen, S; Kristensen, VN1
Wang, YP; Yang, ZP1
Baumhoer, D; Bernstein, M; Bielack, SS; Böhling, T; Brennan, B; Butterfass-Bahloul, T; Calaminus, G; Deffenbaugh, C; Dhooge, C; Eriksson, M; Gebhardt, M; Gelderblom, H; Gerss, J; Goorin, A; Gorlick, R; Helmke, K; Hogendoorn, PC; Hoogerbrugge, PM; Hook, JM; Jovic, G; Jürgens, H; Kager, L; Krailo, MD; Kühne, T; Lau, CC; Letson, GD; Marina, N; Meyer, J; Meyers, P; Michelagnoli, M; Morris, C; Nadel, H; Nagarajan, R; Pápai, Z; Picton, S; Randall, RL; Reichardt, P; Renard, M; Schomberg, P; Seddon, B; Smeland, S; Sundby Hall, K; Sydes, MR; Teot, LA; Tunn, PU; van den Berg, H; Werner, M; Whelan, JS; Windhager, R1
Duan, H; Gong, RR; Xiong, Y; Yang, XR1
Ash, S; Cohen, IJ; Issakov, J; Kollender, Y; Shkalim-Zemer, V; Toledano, H; Yaniv, I1
Bakhshi, S; Batra, A; Khan, SA; Nataraj, V; Rastogi, S; Sharma, MC; Vishnubhatla, S1
Bernstein, ML; Devidas, M; Gebhardt, MC; Goorin, AM; Grier, HE; Healey, JH; Krailo, MD; Lipshultz, SE; Meyers, PA; Sato, JK; Schwartz, CL; Steinherz, LJ; Teot, LA; Wexler, LH1
Fujiwara, M; Fujiwara, T; Kawai, A; Numoto, K; Ogura, K; Suzuki, S; Yonemoto, T; Yoshida, A1
Chintagumpala, M; Helman, L; Hicks, MJ; Jo, E; Krance, R; Lau, C; Meyer, W; Murray, J; Venkatramani, R1
Ferrari, S; Serra, M1
Chen, X; Cheng, Y; He, C; Liu, J; Ma, H; Yang, Z; Zang, J1
Bishop, MW; Brinkman, TM; Cheung, YT; Daryani, VM; Edelmann, MN; Hudson, MM; Kimberg, C; Krull, KR; Liu, W; Mulrooney, DA; Ness, KK; Robison, LL; Srivastava, DK; Stewart, CF1
Effinger, KE; Link, MP1
Ding, M; Huang, J; Jin, Q; Liu, K; Ni, J; Song, D; Wang, J1
Bernstein, ML; DuBois, SG; Gorlick, RG; Janeway, KA; Krailo, MD; Marina, N; Morris, CD; Randall, RL; Teot, LA; Villaluna, D1
Abdul-Rahman, O; Bai, P; Dér, Á; Fodor, T; Kiss, B; Nagy, L; Szántó, M1
Gan, ZH; Han, K; Hu, HY; Li, KP; Lin, SC; Liu, Y; Lu, ZG; Min, DL; Tseng, KF; Zhao, RH; Zhou, Y1
Dinçaslan, H; Ensari, A; Kiremitçi, S; Özçakar, ZB; Taktak, A; Yalçınkaya, F; Yılmaz, S1
Fellenberg, J; Fischer, C; Kunz, P; Lehner, B; Sähr, H; Seebach, E1
Djerada, Z; Feliu, C; Gozalo, C; Marquet, B; Millart, H; Oudart, JB1
Bi, WZ; Han, G; Huang, JQ; Jia, JP; Mao, BB; Wang, DY; Wang, W; Wu, YN; Xu, M1
Biason, P; Fanelli, M; Ferrari, S; Gagno, S; Giodini, L; Hattinger, CM; Iacoboni, E; Picci, P; Roli, A; Roncato, R; Scotlandi, K; Serra, M; Tavanti, E; Toffoli, G; Vella, S1
Antal, P; Arany, A; Csoka, M; Csordas, K; Eipel, O; Erdelyi, DJ; Gezsi, A; Hegyi, M; Kovacs, GT; Kutszegi, N; Muller, J; Semsei, AF; Szalai, C1
Deng, P; Junger, WG; Qi, B; Sun, D; Wang, C; Wang, T; Xia, Y; Yao, J; Yu, T; Zhang, X1
Fanelli, M; Hattinger, CM; Picci, P; Serra, M; Tavanti, E; Vella, S1
Niu, XH; Zhang, Q; Zhang, W; Zhen, JC; Zheng, TT1
Fujiki, M; Kawai, A; Miyamoto, S; Setsu, N1
Azuma, E; Hirayama, M; Imai, H; Iwamoto, S; Komada, Y; Matsumine, A; Miura, Y; Nakatani, K; Toyoda, H; Yodoya, N1
Chakraborty, J; Ray, S; Sa, B; Saha, S1
Park, JA; Shin, HY1
Bagarry-Liegey, D; Ciccolini, J; Deville, JL; Duffaud, F; Dupuis, C; Durand, A; Fanciullino, R; Favre, R; Iliadis, A; Mercier, C; Monjanel-Mouterde, S; Pourroy, B; Yang, C1
Bielack, SS; Ferrari, S; Helman, LJ; Marina, N; Reaman, GH; Smeland, S; Whelan, JS1
Arndt, CA; Hawkins, DS; Hoots, WK; Inwards, CY; Kleinerman, ES; Koshkina, NV; Morales-Arias, JA; Munsell, MF; Rodriguez, NI1
Gorlick, R; Jaffe, N1
Bouchireb, K; Brugières, L; Dodille, A; Dubrel, M; Gouraud, F; Ponvert, C1
Goldwasser, F; Mir, O; Ropert, S1
Cendros, JM; Colom, H; Domenech, J; Farré, R; Mangues, MA; Pardo, N; Peraire, C; Soy, D; Torrent, M1
Castellani, GC; Fanelli, M; Hattinger, CM; Michelacci, F; Pasello, M; Picci, P; Remondini, D; Scionti, I; Scotlandi, K; Serra, M; Stoico, G1
Bjornard, K; Jayabose, S; Kudlowitz, D; Nowicki, TS; Sandoval, C1
Marrodán, L; Patiño-García, A; San-Julián, M; Sierrasesúmaga, L; Zalacaín, M1
de Camargo, B; van Dalen, EC1
Boldrini, R; Cozza, R; De Ioris, MA; Devito, R; Donfrancesco, A; Fidani, P; Zama, M1
Fujimoto, T; Hamada, K; Hashimoto, N; Hatazawa, J; Inoue, A; Myoui, A; Tomita, Y; Yoshikawa, H1
Kalicanin-Markovska, M; Kostadinova-Kunovska, S; Samardziski, M; Tolevska, C; Zafiroski, G; Zafirova-Ivanovska, B1
Cheok, MH; Evans, WE; Kager, L1
Gunes, D; Gurcu, O; Koroglu, T; Olgun, N; Ozguven, AA; Uysal, K1
Abate, ME; Bacci, G; Balladelli, A; Cesari, M; Ferrari, S; Longhi, A; Palmerini, E; Pratelli, L; Staals, E1
Jeon, SC; Kim, JH; Koh, HC; Lee, YH; Lim, YJ; Oh, SH1
Ferraresi, V; Prencipe, U; Salducca, N; Zoccali, C1
Botchkina, GI; Bruheim, S; Fodstad, O; Formentini, A; Gavin, E; Ju, J; Kornmann, M; Kudo, K; Song, B; Wan, Y; Wang, Y; Xi, Y1
Al Omar, S; Tuffaha, HW1
Wilkes, GM1
Cohen, IJ2
Alten, JA; Askenazi, DJ; Haines, H; Mueller, BA; Vilay, AM1
Alexandre, J; Anract, P; Babinet, A; Durand, JP; Enkaoua, E; Goldwasser, F; Larousserie, F; Mir, O; Ropert, S1
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Fudenberg, HH; Hynes, JB; Tsang, KY1
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Goto, M; Ishii, S; Isu, K; Nakasato, T; Sasaki, T; Ubayama, Y; Usui, M; Yagi, T; Yamawaki, S1
Hosoya, R; Howell, SK; Sutow, WW; Wang, YM1
Bowles, D; Evans, WE; Green, AA; Howarth, C; Kumar, AP; Pratt, CB; Ransom, JL; Rivera, G1
Neerhout, RC; Renholds, DC; Ridgway, D; Wolff, LJ1
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Göbel, U; Jürgens, H; Rosen, G; von Voss, H; Wahn, V1
Gehan, EA; Sutow, WW1
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Huvos, AG; Juergens, H; Kosloff, C; Mehta, BM; Nirenberg, A; Rosen, G1
Abelson, HT; Frei, E; Goorin, AM2
Cortes, EP; Holland, JF1
Pratt, CB1
Goto, M1
Bernstein, ID; Bleyer, WA; Chard, RL; Feigl, P; Greenlee, TK; Haas, JE; Hartmann, JR; Johnson, FL; Morgan, A; Pendergrass, TW; Schaller, RT1
Caparros, B; Caravelli, JF; Heelan, RT; Huvos, AG; Rosen, G; Smith, J; Urmacher, C1
Nakamura, T1
Evans, AE; Gregg, JR; Kramer, S; Lange, B; Toledano, S; Wimmer, R1
Bertolone, SJ; Clark, LW; Hilton, MA; Kmetz, DR; Patel, CC1
Nirenberg, A; Rosen, G1
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Lowe, J; Makin, M; Sulkes, A1
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Amino, K1
Cantwell, BM; Fennelly, JJ; Jones, MP1
Diehl, V; Engelhardt, P; Oellerich, M; Schaadt, M1
Cregan, ET; Dahlin, DC; Edmonson, JH; Gilchrist, GS; Green, SJ; Ivins, JC; Pritchard, DJ; Smithson, WA; Taylor, WF1
Franchimont, C; Pierard, GE1
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Chiari, K; Endler, T; Gabl, F; Kotz, R; Krisch, K; Leber, H; Salzer-Kuntschik, M1
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Rosenberg, SA1
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Ho, KC; Ho, SK; Johnson, PJ; Kumta, SM; Leung, WT; Lin, J; Metreweli, C1
Bramwell, V; Mertens, WC1
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Krailo, M; Miser, JS1
Avella, M; Bacci, G; Casadei, R; Cazzola, A; Ferrari, S; Lari, S; Monti, C; Picci, P; Prever, BA; Ruggieri, P1
Heller, G; Meyers, PA; Vlamis, V1
Delepine, G; Delepine, N; Desbois, JC2
Contesso, G; Edeline, V; Kalifa, C; Lemerle, J; Razafindrakoto, H; Valteau, D; Vanel, D; Vassal, G1
Ekert, H; Tiedemann, K1
Göeken, LN; Kamps, WA; Molenaar, WM; Postma, A; Schraffordt Koops, H; Veth, RP1
George, M; Goorin, A; Letvak, LA; Link, M; Poplack, D; Strother, D1
Kabuto, M; Kitai, R; Kobayashi, H; Kodera, T; Kubota, T; Nakagawa, T; Nozaki, J; Sato, K1
Hsi, SN; Kiu, MC; Lai, GM; Liaw, CC; Lu, CS; Yang, TS1
He, Q; Li, HG; Ma, ZT1
Kalifa, C; Lemerle, J; Raquin, M; Rodary, C; Tabone, MD; Valteau-Couanet, D1
al-Lamki, Z; el-Banna, N; Jaffe, N; Thomas, E1
Betlemovic, M; Bode, U; Fuchs, N; Graf, N; Winkler, K1
Bacci, G; Fabbri, A; Ferrari, S; Figus, E; Longhi, C; Marchesini, G; Marchi, E; Motta, E1
Burgers, JM1
Higaki, S; Takeyama, S; Tateishi, A; Yamanashi, M1
Astier, A; Brun, B; Goutallier, D; Hernigou, P; le Bourgeois, JP1
Burgers, JM; Craft, AW1
Bauer, HC; Brosjö, O; Kreicbergs, A; Lindholm, J; Nilsonne, U; Silfverswärd, C; Strander, H; Szamosi, A1
Elomaa, I1
Arndt, CA; Edmonson, JH; Gilchrist, GS; Miser, JS; Pritchard, DJ; Rock, MG; Schaid, DJ; Shives, TC; Smithson, WA1
Ayass, M; Cassano, W; Dickson, N; Enneking, W; Graham-Pole, J; Heare, M; Heare, T; Marcus, R; Saleh, R; Spanier, S1
Advani, SH; Dinshaw, KA; Pande, SC; Suraiya, JN; Susnerwala, SS1
Rosen, G4
Fukaya, N; Katagiri, H; Nakanishi, K; Sato, K; Sugiura, H; Takahashi, M; Yamamura, S1
Chauveinc, L; Follezou, JY; Guerin, JM1
Cui, TH1
Fujinami, S; Nakaseko, K; Ogihara, Y1
Bacci, G; Brach Del Prever, A; Casadei, R; Ferrari, S; Mancini, A; Picci, P; Tienghi, A1
Bacci, G; Brach del Prever, A; Casadei, R; Ferrari, S; Gherlinzoni, F; Mercuri, M; Monti, C; Picci, P; Ruggieri, P; Tienghi, A1
Borsi, J; Kálmánchey, R; Koós, R; Majtényi, K1
Carlson, RW; Catolico, M; Reid, T; Yuen, A1
Borsi, JD; Koós, R; Kovács, GT; Paál, C; Schuler, D; Somló, P1
Andoh, J; Beaumel, A; Hilaire, A; Konata, I; Kouie, JP; M'Bengue, TA; Quattara, DN; Toutoukpo, Y1
Nakano, M; Norimatsu, H; Oka, S; Tsukamoto, T; Yoshioka, S1
Barrett, G; George, M; Jaffe, N; Jorgensen, K; Letvak, L; Robertson, R1
Catalin, J; Duffaud, F; Durand, A; Favre, R; Guillet, P; Lacarelle, B; Monjanel, S; Pignon, T1
Liu, JQ; Wu, DW1
Cho, KJ; Jang, JJ; Jeon, DG; Kim, SS; Lee, SY1
Avidor, I; Cohen, IJ; Goshen, Y; Kaplinsky, C; Katz, K; Mor, C; Yaniv, Y; Yosipovitch, Z; Zaizov, R1
Kotz, R; Mader, RM; Proprentner, R; Rainer, H; Rizovski, B; Steger, GG1
Avella, M; Figus, E; Gnudi, S; Ripamonti, C1
Bacci, G; Battistini, A; Ferrari, S; Orlandi, M; Puggioli, C; Sassoli, V; Strazzari, S1
Couthon, HM; Hosain, F; Spencer, RP; Sturtz, GL1
Al-Lamki, Z; Jaffe, N; Pearson, P1
Bessis, D; Guilhou, JJ; Hellier, I; Margueritte, G; Sotto, A1
Adamson, PC; Balis, FM; Hetherington, ML; Murphy, RF; Widemann, BC1
Alkins, SA; Byrd, JC; Morgan, SK; Ward, FT; Weiss, RB1
Butenko, AK; Glukhovskaia, IIu; Konovalenko, VF; Tolstopiatov, BA1
Goorin, A; Hallowell, JA; Kharasch, VS; Lipsitz, S; Santis, W1
Marcove, RC2
Dembowska-Bagińska, B; Jurczyk-Procyk, S; Kozera, M; Perek, D; Piekarczyk, A; Prokopczyk, J; Wieckowska, J; Witkowska-Ozogowska, J; Zelazowski, J1
Aoki, M; Hino, M; Honoki, K; Kido, A; Mii, Y; Miura, S; Miyauchi, Y; Morishita, T; Nakanishi, E; Nomura, Y; Tamai, S1
Amaya, J; Aymerich, ML; Calvo, M; Maldonado, S; Muñoz Villa, A; Ocete, G; Otheo, E1
Bacci, G; Bertoni, F; Comandone, A; Ferrari, S; Ferraro, A; Mercuri, M; Picci, P; Ruggieri, P; Tella, G1
Bacci, G; Delepine, G; Delepine, N; Desbois, JC; Rosen, G1
Barisone, E; Brach Del Prever, A; Leone, L; Miniero, R; Ridolfi, L; Vivalda, M; Vivenza, C1
Fujimoto, T1
Bacci, G; Cazzola, A; Ferrari, S; Gherlinzoni, F; Iantorno, D; Picci, P; Zolezzi, C1
Baum, ES; Betcher, DL; Ettinger, LJ; Huvos, AG; Kisker, CT; Krailo, MD; Makley, JT; Miser, JS; Nachman, JB; Provisor, AJ; Yunis, EJ1
Bacci, G; Bertoni, F; Briccoli, A; Donati, D; Ferrari, S; Forni, C; Manfrini, M; Mercuri, M; Monti, C; Zanoni, A1
Araki, N; Myoui, A; Shinto, Y; Uchida, A; Ueda, T; Yoshikawa, H1
Connolly, LP; Ecklund, K; Goorin, AM; Jaramillo, D; Laor, T1
al Mahr, M; Hughes, DO; Lee, DB; Leung, S; Marshall, GM; Tobias, V1
Alvegård, TA; Björk, O; Elomaa, I; Saeter, G; Solheim, OP; Strander, H; Wiebe, T1
Hamada, M; Inoue, H; Kawai, A; Kunisada, T; Sugihara, S1
Alexandre, J; Brain, E; Minozzi, C; Misset, JL1
Clifton-Bligh, P; Jackson, C; Laurent, MR; Mason, RS; Preston, SJ1
Hayakawa, M; Ishii, S; Kawaguchi, S; Murakami, M; Uede, T1
Bertino, JR; Fan, J; Hochhauser, D; Li, WW1
Beron, G; Bielack, SS; Winkler, K1
Bacci, G; Bertoni, F; Campanacci, M; Cesari, M; Ferrari, S; Forni, C; Gasbarrini, A; Mercuri, M; Sottili, S; Tienghi, A1
Bacci, G; Brach del Prever, A; Briccoli, A; Ferrari, S; Gasbarrini, A; Mercuri, M; Picci, P; Pinto, D; Tienghi, A1
Andersen, A; Bruland, OS; Ekstrøm, PO; Giercksky, KE; Slørdal, L1
Glukhovskaia, IIu1
Bacci, G; Ferrari, S; Mercuri, M; Picci, P1
Bacchini, P; Bacci, G; Bertoni, F; Brach del Prever, A; Campanacci, M; Comandone, A; Delepine, N; Ferrari, S; Mercuri, M; Picci, P; Tienghi, A1
Bruland, OS; Pihl, A1
Bacci, G; Bernini, G; Brach del Prever, A; Capanna, R; Cesari, M; Comandone, A; Ferrari, S; Longhi, A; Mercuri, M; Picci, P; Tienghi, A1
Koshino, T; Saito, T; Takagi, T; Yoshida, K1
Bertino, JR; Gorlick, R; Kellick, M; Meyers, P1
Casper, E; Gorlick, R; Healey, JH; Heller, G; Huvos, AG; Lane, J; Meyers, PA1
Aronson, J; Jarka, DE; Nicholas, RW1
Brunat-Mentigny, M; Cochat, P; Dubourg, L; Hadj-Aïssa, A; Koch Nogueira, PC; Schell, M1
Bielack, SS; Bieling, P; Delling, G; Epler, D; Fuchs, N; Graf, N; Heise, U; Jürgens, H; Körholz, D; Kotz, R; Salzer-Kuntschik, M; Weinel, P; Werner, M; Winkler, K1
Ayala, A; Ferguson, WS; Gieser, P; Goorin, AM; Harris, MB; Holbrook, T; Link, MP; Shochat, SJ1
Enneking, WF; Lindner, NJ; Scarborough, MT; Spanier, SS1
Amigo-Ferreiro, ME; Bonnay, M; Grill, J; Hartmann, O; Schoepfer, C; Valteau-Couanet, D; Vassal, G1
Bailey, CC; Gattamaneni, HR; Lashford, LS; Lewis, IJ; Michelagnoli, MP1
Bertino, JR; Gorlick, R; Guo, W; Healey, JH; Huvos, AG; Ladanyi, M; Meyers, PA1
Bacci, G; Cesari, M; Fasano, MC; Ferrari, S; Lamanna, G; Zolezzi, C1
Iqbal, MP1
Flombaum, CD; Meyers, PA1
Hoare, D; Leonard, P; Whelan, J1
Cohen, IJ; Katz, K; Kidron, D; Meller, I; Tomer, G; Yosipovitch, Z; Zaizov, R1
Alvegård, TA; Brosjö, O; Engström, K; Follerås, G; Forestier, E; Holmström, T; Monge, O; Saeter, G; Stenwig, AE; Strander, H; Wahlqvist, Y; Wiebe, T; Wiklund, T; Willén, H1
Ashihara, T; Hashiguchi, S; Hirasawa, Y; Hirata, M; Kusuzaki, K; Murata, H; Takeshita, H1
Carter, SR; Grimer, RJ; Kabukcuoglu, Y; Mangham, DC; Spooner, D; Tillman, RM1
Babin-Boilletot, A; Brunat-Mentigny, M; Kalifa, C; Mahmoud, HH; Pacquement, H; Schmitt, C; Tabone, MD; Terrier, P1
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Aparicio, J; Garcerá, S; Montalar, J; Munárriz, B; Oltra, A; Pastor, M; Santaballa, A; Segura, A; Yuste, A1
Akamatsu, N; Hamada, Y; Seki, K; Shiiki, K; Tasaka, K; Yoshikawa, H1
Horiuchi, R; Shinozaki, T; Takagishi, K; Tomidokoro, R; Watanabe, H; Yamamoto, K1
Ben Abdallah, M; Ben Ayed, F; Ben Ghachem, M; Ben Hamida, H; Ben Hassine, H; Ben Romdhane, K; Boussen, H; Daldoul, O; Douik, M; Gamoudi, A; Karray, S; Khalfallah, S; Mezlini, A; Mezzi, F; Saadi, A1
Debatin, KM; Ewerbeck, V; Fellenberg, J; Mau, H; Nedel, S1
Boruczkowski, D; Chybicka, A; Gołebiowski, W; Jaworski, W; Katski, K; Kazanowska, B; Kowalczyk, J; Kołecki, P; Leda, M; Liebhart, M; Wecławek-Tompol, J; Woźniak, W1
Hirata, Y; Kato, T; Kobayashi, H; Morita, T; Okada, Y; Sato, T1
Decker, S; Nies, B; van Valen, F; Winkelmann, W1
Hanioka, K; Hayashi, Y; Kizaki, T; Marui, T; Minami, R; Mizuno, K; Yamamoto, T1
Akman, S; Carroll, MI; Doroshow, JH; Leong, LA; Longmate, JA; Margolin, KA; Morgan, RJ; Newman, EM; Raschko, JW; Slatkin, N; Somlo, G; Tetef, ML1
Ben Arush, MW; Ben-Barak, A; Elhasid, R; Levin, K; Postovsky, S1
Aldaz, A; Aquerreta, I; Beorlegui, B; Giráldez, J; Ortega, A; Sierrasesúmega, L1
Bacci, G; Bertoni, F; Campanacci, M; Casadei, R; Fabbri, N; Ferrari, S; Forni, C; Longhi, A; Picci, P; Ruggieri, P; Versari, M1
Craft, AW; Lewis, IJ; Machin, D; Stark, D; Weeden, S1
Cole, PD; Kamen, BA1
Bacci, G; Bertoni, F; Fabbri, N; Ferrari, S; Forni, C; Longhi, A; Versari, M; Zavatta, M1
Bacchini, P; Bacci, G; Bertoni, F; De Giorgi, U; Ferrari, S; Fiorentini, G; Forni, C; Longhi, A; Mercuri, M; Picci, P; Rimondini, S; Tienghi, A1
Gebski, V; Machin, D; Tai, BC; White, I1
Arbizu, J; López de Mesa, R; Narbona, J; Sánchez-Carpintero, R; Sierrasesúmaga, L1
Goto, E; Okamoto, I; Tanaka, K; Tomojiri, S1
Bacchini, P; Bacci, G; Bertoni, F; Campanacci, L; Campanacci, M; Donati, D; Ferrari, S; Forni, C; Longhi, A; Picci, P1
Bacci, G; Bernini, G; Biagini, R; Briccoli, A; Capanna, R; Donati, D; Fabbri, N; Ferrari, S; Longhi, A; Versari, M1
Abe, S; Ganev, GG; Nakano, H; Ogawa, K; Tateishi, A1
Auvrignon, A; Dalle, JH; Kalifa, C; Leverger, G; Vassal, G1
Berend, KR; Dibernardo, L; Harrelson, JM; Moore, JO; Pietrobon, R; Scully, SP1
Chowbay, B; Siong, KK1
Kim, HS; Lee, SH; Oh, JH; Park, YB; Yoo, KH1
Hu, Y; Lei, S; Mao, Y; Pei, F; Wei, Y; Zeng, J1
Blum, R; Seymour, JF; Toner, G1
Takahashi, M; Yamada, K; Yoshida, M1
Hisada, T; Ito, T; Masuda, S; Mochida, A; Morinari, H; Nakahara, K; Nishi, K; Saito, K; Sasaki, S; Tahara, M; Yakumaru, K1
Auvrignon, A; Dalle, JH; Leverger, G; Vassal, G1
Alvegard, TA; Bacci, G; Briccoli, A; Donati, D; Ferrari, S; Forni, C; Lari, S; Longhi, A; Manfrini, M; Mercuri, M; Picci, P; Saeter, G1
Boruczkowski, D; Chybicka, A; Gołebiowski, W; Jaworski, W; Katski, K; Kazanowska, B; Kijowski, J; Kowalczyk, J; Kołecki, P; Leda, M; Liebhart, M; Wecławek-Tompol, J; Woźniak, W1
Hauben, EI; Hogendoorn, PC; Pringle, J; Van Marck, EA; Weeden, S1
Douglass, HO; Friedman, M; Mindell, E; Takita, H; Wallace, HJ; Wang, J1
Arbes, H; Kotz, R; Leber, H; Ramach, W; Wolf, A1
Kubanek, B; Schreml, W1
Caparros, B; Huvos, AG; Kosloff, C; Marcove, RC; Nirenberg, A; Rosen, G1
Bourne, RG1
Nirenberg, A1
Kotz, R; Leber, H; Rella, W1
Evans, AE1
Burchenal, JH2
Livingston, RB1
Sullivan, MP; Sutow, WW1
Eveloff, AR; Lascari, AD1
Kotz, D; Krisch, K; Mehta, BM1
Jenkin, RD1
Austin, EH; Drake, J; Goldberg, NH; Romolo, JL; Rosenberg, SA1
Butler, TP; Sybert, A1
Etcubanas, E; Giritsky, AS; Mark, JB1
Handelsman, H; Muggia, FM1
Janka, G1
Jungi, WF1
Harms, D; Lasson, U; Wiedemann, HR1
Bohndorf, W1
Becker, W; Bühner, R; Geiger, H1
Jani, L; Sartorius, J1
Baygell, PD; Leyva, A; Pinedo, HM; Pintus, C; Spreafico, F; van Asten, P; van Loenen, AC1
Kotz, R2
Louie, AC; Muggia, FM; Rozencweig, M; von Hoff, DD1
Perez, C; Romsdahl, MM; Sutow, WW; Wang, YM1
Conkle, D; Flye, MW; Levine, AS; Rosenburg, SA; Seipp, CA; Simon, RM1
Kadouche, J; Lokiec, F; Najean, Y1
Breur, K; van der Schueren, E1
Prindull, G1
Mulder, JH; van Putten, LM1
Barofsky, I; Chang, AE; Goldberg, NH; Rosenberg, SA; Seipp, CA; Shiling, DJ; Simon, RM; Stillman, RC1
Fuchs, K; Poppe, H; Prindull, G1
Huvos, AG; Marcove, RC; Rosen, G1
Frei, E; Jaffe, N; Traggis, D; Watts, H2
Hustu, O; Kumar, AP; Pratt, C; Rivera, G; Shanks, E; Smith, J1
Huvos, AG; Lewis, MM; Marcove, RC; Rosen, G1
Cassady, RJ; Filler, RM; Jaffe, N; Murray, J; Traggis, D; Watts, H; Weichselbaum, R; Weinstein, H1
Pratt, CB; Rivera, G; Shanks, E1
Bertino, JR2
Cassady, JR; Filler, RM; Frei, E; Jaffe, N; Traggis, D; Watts, H2
Miller, TR1
Goldberg, NH; Hande, KR; Romolo, JL; Rosenberg, SA1
Delling, G; Gaedicke, G; Grosch-Wörner, I; Landbeck, G; Marsmann, G; Winkler, K1
Huvos, AG; Marroum, MC; Rosen, G1
Fellows, K; Frei, E; Jaffe, N; Traggis, D; Vawter, G; Watts, H1
Bono, VH; Catane, R; Louie, AC; Muggia, FM1
Frei, E; Gero, M; Jaffe, N; Skipper, H; Watts, H1
Alsop, JA1
Beattie, EJ; Capparos, B; Exelby, PR; Huvos, AG; Marcove, RC; Mosende, C; Rosen, G1
Bender, RA; Louie, AC; Muggia, FM; Rozencweig, M; Von Hoff, DD1
Sauer, H; Wilmanns, W1
Breiter, DN; Diasio, RB; Neifeld, JP; Rosenberg, SA; Roush, ML1
Kim, PY; Lantin, E; Romsdahl, MM; Sutow, WW; van Eys, DC; Wang, YM1
Mills, EE1
Höffken, K; Hupfauer, W; Schmidt, CG; Seeber, S1
Allen, JC; Rosen, G1
Cotter, SM; Parker, LM1
Ambinder, EP; Biller, HF; Holland, JF; Ohnuma, T; Perloff, M1
Chabner, BA; Costa, J; Hanson, TA; Head, GC; Levine, AS; Rosenburg, SA; Seipp, CA; Simon, RM; Young, RC1
Bidlingmaier, F; Haas, RJ; Janka, GE; Wiesner, H1
Gutjahr, P; Tröger, J1
Herson, J; Perez, C; Sutow, WW; Wang, YM2
Grinnel, J; Kidd, W; Peck, C; Pratt, CB; Roberts, D1
Lohrmann, HP; Schremi, W1
Sauer, H; Schalhorn, A; Wilmanns, W1
Barker, LF; Crom, WR; Evans, WE; Pratt, CB; Taylor, RH1
Waters, KD1
Meuret, G1
Eilber, FR; Grant, T; Morton, DL1
Fellows, KE; Jaffe, N; Vawter, G; Watts, H1
Appelbaum, FR; Graw, RG; Levine, AS; Magrath, IT; Pizzo, PA; Poplack, DG; Ziegler, JL1
George, S; Green, AA; Kumar, AP; Pratt, CB; Rivera, G; Shanks, E1
Etcubanas, E; Wilbur, JR1
Edmonson, JM; Gilchrist, GS; Ivins, JC; Pritchard, DJ; Ritts, RE; Taylor, WF1
Camitta, BM; Holcenberg, JS1
Cohen, HJ; Jaffe, N1
Bacci, G; Campanacci, M; Pagani, P; Picci, P1
Jasińska-Rubach, M; Zborzil, J1
Kotz, R; Krisch, K; Mutz, I; Urban, C1
Chabora, BM; Rosen, G; Tefft, M1
Cassady, JR; Filler, RM; Jaffe, N; Weichselbaum, RR1
Chang, P1
Jaffe, N; Watts, HG1
Frei, E1
Fudenberg, HH1
Ivins, JC; Pritchard, DJ1
Campbell, CJ; Cohen, J; Enneking, WF1
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Ferguson, RJ; McMaster, JH; Weinert, CR1
Mindell, ER; Sinks, LF1
Ginapolous, H; Khan, FR; Nickson, JJ1
Foley, TP; Kenny, FM; McMaster, JH; Scranton, PE; Taylor, FH1
Hollinger, MJ; Robertson, JH; Wilson, C1
Bacci, G; Pagani, PA1
Chabner, BA; Jacobs, SA; Johns, DG; Stoller, RG1
AKAHOSHI, Y; Chen, SH; Kikuike, A; Nishimoto, T; Takeuchi, S; Yamamuro, T; Yonezawa, H1
Hägerström, T; Humla, S; Nordenskjöld, B; Skoog, L1
Green, AA; Pratt, C; Smith, K; Webster, RG1
Sweetnam, R1
Bacci, G; Donati, U; Pagani, PA1
Frei, E; Jaffe, NJ; Pitman, S1
Beattie, EJ; Martini, N; Rosen, G1
Cham, W; Martinez, A; Murphy, ML; Rosen, G; Tefft, M1
Beattie, EJ; Marcove, R; Murphy, ML; Rosen, G; Sanmaneechai, A; Tan, C1
Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH1
Price, CH1
Djerassi, I1
Staudt, AR1
Marcove, RC; Martini, N; Rosen, G1
Bagshaw, MA; Donaldson, SS; Goffinet, DR; Kaplan, HS; Wilbur, JR1
Gutierrez, M; Huvos, AG; Marcove, RC; Murphy, ML; Rosen, G1
Corder, MP; Stone, WH1
Dyment, PG; Frias, AE; Gehan, EA; Sutow, WW; Vietti, TJ1
Freedman, A; Irving, MG; Lam-Po0Tang, R; O'Gorman-Hughes, D; Salasoo, S1
Bleehen, NM1
Gilchrist, GS; Ivins, JC; Miller, GC; Pritchard, DJ; Ritts, RE; Taylor, WF1
Hilton, MA; Kmetz, DR; Patel, CC1
Carter, SK; Handelsman, H1
Hirano, T; Iwasaki, K; Kumashiro, T; Sadamatsu, T1
Applewhite, A; Healey, J; Heller, G; Huvos, A; Lane, J; Marcove, R; Meyers, PA; Rosen, G; Vlamis, V1
Bramwell, VH; Burgers, M; Craft, AW; Rouesse, J; Sneath, R; Somers, R; Souhami, R; Spooner, D; van Oosterom, AT; Voûte, PA1
Charpentier, A; de Baere, T; di Paola, M; Shapeero, LG; Terrier, P; Vanel, D1
Gutjahr, P; Reitz, M2
Iqbal, MP; Malik, I; Mehboobali, N1
Baba, H; Tomita, K; Tsuchiya, H; Ueda, Y; Yasutake, H; Yokogawa, A1
Avella, M; Bacci, G; Battistini, A; Brach del Prevert, A; Casadei, R; Ferrari, S; Mancini, A; Picci, P; Ruggieri, P; Tienghi, A1
Doz, F; Michon, J; Pacquement, H; Quintana, E; Zucker, JM1
Berthau, N; Courpied, JP; Coutant, M; Daugu, M; Dorval, T; Forest, M; Palangie, T; Pouillart, P; Tomeno, B1
Amar, D; Barst, SM; McDowall, RH; Scher, CS1
Fairclough, DL; Fletcher, BD; Hanna, SL; Le, AH; Meyer, WH; Parham, DM1
Avella, M; Bacci, G; Caldora, P; Ferrari, S; Ferraro, A; Orlandi, M; Ravazzolo, G1
Affleck, K; Embleton, MJ1
Alvegård, TA; Elomaa, I; Saeter, G; Solheim, OP1
Blomqvist, C; Elomaa, I; Holmström, T; Karaharju, E; Laasonen, E; Ryöppy, S; Siimes, MA1
Houghton, JA; Houghton, PJ; Loftin, SK; Meyer, WH1
Bröcheler, J; Mertens, R; Niedeggen, A; Röther, J; Weis, J1
Atanacković, M; Barjaktarević, Z; Bekić, Z; Munjas, N; Sbutega, B1
Eldridge, RM; Fleming, RA; Johnson, CE; Stewart, CF1
Buchanan, GR; Pappo, A; Sanders, JM; Schneider, NR1
Glasser, DB; Lane, JM1
Bielack, S; Bieling, P; Delling, G; Dose, C; Jürgens, H; Kotz, R; Ritter, J; Salzer-Kuntschik, M; Winkler, K1
Alvegård, TA; Elomaa, I; Holmström, T; Saeter, G; Solheim, OP; Stenwig, AE1
Abuchaibe, O; Antillon, F; Azinovic, I; Calvo, FA; Cañadell, J; Ortiz de Urbina, D; Santos, M; Sierrasesúmaga, L1
Jurczyk-Procyk, S; Perek, D1
Jaffe, N; Jeha, S; Robertson, R1
Bissett, D; Kaye, SB; Kerr, DJ1
Achkar, A; Gajdos, P; Korach, JM; Laaban, JP; Sacquin, P; Troché, G1
Blais, JC; Dhondt, JL; Hayte, JM; Klein, R; Millot, F; Pfleiderer, W1
Ferrari, AM; Marsden, FW; McCarthy, SW; Stephens, FO1
Kotz, R; Kropej, D; Ritschl, P; Salzer-Kuntschik, M; Schiller, C1
Figueiredo, MT; Gentil, FC; Lopes, A; Penna, V; Petrilli, S1
Fujinami, S; Miura, T; Ogihara, Y; Sato, K; Sudo, A1
Avella, M; Bacci, G; Dallari, D; De Cristofaro, R; Ferruzzi, A; Manfrini, M; Marangolo, M; Mercuri, M; Picci, P; Pignatti, G1
Bacchini, P; Bacci, G; Bertoni, F; Capanna, R; Dallari, D; Picci, P; Pignatti, G1
Cserhati, MD; Exner, GU; Groscurth, P; Honegger, HP; von Hochstetter, A1
Affleck, K; Charleston, A; Embleton, MJ1
Blomquist, L; Larsson, SE; Smeds, S; Walz, T1
Jaffe, N; Kleinerman, ES; Snyder, JS1
Blomlie, V; Fosså, SD; Lien, HH; Saeter, G; Solheim, O1
Earl, H; Shamash, J; Souhami, R1
Cornille, H; Delépine, G; Delépine, N; Desbois, JC; Jasmin, C1
Campanacci, M; Cascinelli, N; Picci, P; Santinami, M; Vaglini, M1
Iqbal, MP; Malik, IA1
Fiorentini, G; Graziani, G; Molinari, M; Priori, T; Tienghi, A1
Bührer, C; Laszig, R; Reiter, A; Riehm, H; Sauter, S; Weinel, P1
Bielack, S; Delling, G; Erttmann, R; Greenshaw, C; Jürgens, H; Kotz, R; Kusnierz-Glaz, C; Ritter, J; Salzer-Kuntschik, M; Winkler, K1
Chernichenko, VA; Konovalenko, VF; Monich, AIu; Palivets, AIu; Tolstopiatov, BA1
Ayala, A; Carrasco, H; Hudson, M; Jaffe, MR; Jaffe, N; Murray, J; Raymond, AK; Robertson, R; Wallace, S1
Avella, M; Bacci, G; Biagini, R; Caldora, P; Campanacci, M; Casadei, R; Ferruzzi, A; Picci, P; Ruggieri, P1
Kuzuya, T; Miura, T; Mizuno, M; Nakanishi, K; Sato, K; Sato, T; Takahashi, M1
Isii, S; Isu, K; Takeda, N; Ubayama, Y; Usui, M; Yagi, T; Yamawaki, S1
Avella, M; Bacci, G; Brach Del Prever, A; Capanna, R; Gherlinzoni, F; Mancini, A; Mercuri, M; Padovani, G; Picci, P; Ruggieri, P1
Avella, M; Bacci, G; Caldora, P; Dallari, D; Di Scioscio, M; Ferrari, S; Malaguti, C; Picci, P; Prasad, R1
Maeda, A; Sakurai, M; Uchida, A; Wakasa, K; Yoshikawa, H1
Morgan, H; Mott, M; Oakhill, A; Verity, CM1
Eremina, LA; Fedenko, AN; Manziuk, LV; Moldovanova, LK; Perevodchikova, NI; Singin, AS; Siniukov, PA1
Baum, LG; Feig, SA; Villareal, B; Vinters, HV1
Eschenbach, C; Maroske, D; Winkler, K1
Delling, G; Hajek, P; Kotz, R; Kumpan, W; Lechner, G; Salzer-Kuntschik, M; Sekera, J; Wittich, GR1
Huvos, AG; Marcove, R; Nirenberg, A; Rosen, G1
Dawson, P; Dean, L; Nachman, J; Shermeta, D; Simon, MA; Vogelzang, NJ1
Bauters, F; Fenaux, P; Jouet, JP; Lai, JL; Lepelley, P1
Berger, J; Beron, G; Delling, G; Gerein, V; Heise, U; Jürgens, H; Kabisch, H; Purfürst, C; Ritter, J; Winkler, K1
Bachelot, C; Boitetot, A; Brunat-Mentigny, M; Demaille, MC; Gentet, JC; Noir, P; Olive, D; Quitana, E; Roche, H; Thyss, JP1
Contesso, G; Dubousset, J; Kalifa, C; Lumbroso, J; Mlika, N; Vanel, D1
Bielack, S; Delling, G; Knop, J; Winkler, K1
Beppu, Y; Chuman, H; Fukuma, H1
Baranzelli, MC; Bouretz, JC; Demaille, MC; Dusol, F; Gosselin, P1
Avella, M; Bacchini, P; Bacci, G; Bertoni, F; Campanacci, M; Dallari, D; Fontana, M; Mercuri, M; Pignatti, G1
Heikkinen, E; Lanning, M; Lanning, P1
Iqbal, MP; Khursheed, M; Mahboobali, N1
Chuman, H; Shinohara, N; Yokoyama, K1
Benoit, J; Delepine, G; Goutallier, D; Hagege, G; Hernigou, P; Leroux, P; Thiéry, JP; Voisin, MC1
Ciminari, R; Pelotti, P; Rimondi, E1
Alkallaf, S; Astier, A; Cornille, H; Delepine, G; Delepine, N; Desbois, JC1
Diddens, H; Frese, G; Gekeler, V; Handgretinger, R; Henze, G; Niethammer, D; Probst, H; Schmidt, H1
Harris, MB1
Nomura, S; Tomita, K; Tsuchiya, H1
Kontani, T; Nomura, S; Tomita, K; Tsuchiya, H1
Bertolone, S; Hilton, MA; Patel, CC1
Kickinger, W; Kotz, R; Ritschl, P1
Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC1
Ayela, P; Bracco, J; Caldani, C; Cassuto, E; Milano, G; Montagne, N; Schneider, M; Thyss, A1
Hoekstra, HJ; Hogeboom, WR; Mooyaart, EL; Oosterhuis, JW; Postma, A; Schraffordt Koops, H; Veth, RP1
Ebner, F; Einspieler, R; Justich, E; Kleinert, R; Radner, H; Ranner, G; Slavc, I; Urban, C1
Kubar, J; Milano, G; Namer, M; Schneider, M; Thyss, A1
Twelves, CJ1
Goren, MP; Horowitz, ME; Meyer, WH; Wright, RK1
Gill, M; McCarthy, M; Murrells, T; Silcocks, P1
Beauchamp, CP; Chan, KW; Knowling, M1
Tateishi, A1
Basco, VE; Knowling, MA1
Houghton, JA; Houghton, PJ; Meyer, WH1
Christophidis, N; Cosolo, W1
Albisinni, U; Bacci, G; Biagini, R; Capanna, R; Galletti, S; Manfrini, M; Picci, P; Pignatti, G1
Baranzelli, MC; Bouretz, JC; Cazin, JL; Debeugny, P; Demaille, MC; Gosselin, P; Lecomte-Houcke, M1
Rouëssé, J; Tubiana-Hulin, M1
Avella, M; Bacci, G; Brach Del Prevert, A; Campanacci, M; Capanna, R; Fiorentini, G; Malaguti, C; Picci, P; Rosito, P1
Cornille, H; Delepine, G; Delepine, N; Desbois, JC; Jasmin, C; Mathé, G1
Gotch, M; Isu, K; Matsuno, T; Nojima, T; Sasaki, T; Ubayama, Y; Yagi, T; Yamaguchi, H; Yamawaki, S1
Avella, M; Bacci, G; Butturini, L; Gnudi, S; Ripamonti, C1
Avella, M; Bacci, G; Boriani, S; Capanna, R; Dallari, D; Galletti, S; Giunti, A; Madon, E; Mancini, A; Mercuri, M1
Lappalainen, K; Maiche, AG; Teerenhovi, L1
Borsi, JD; Moe, PJ; Schuler, D1
Crom, WR; Evans, WE; Jones, DP; McKay, CP; Meyer, W; Ochs, J; Relling, MV; Stapleton, FB; Wainer, IW1
Feng, FY; Lu, L; Song, SZ; Sun, Y; Wang, QL; Yie, ZS; Zhou, JC1
al-Jilaihawi, AN; Bullimore, J; Mott, M; Wisheart, JD1
Grem, JL; King, SA; Leyland-Jones, B; Wittes, RE1
Barnes, L; Baum, E; Bleyer, WA; Ertel, I; Fryer, CJ; Hammond, GD; Krailo, M; Makley, J; Weetman, R; Yunis, E1
Adachi, N; Fukuma, H; Hanada, M; Ohira, M; Takayama, J1
Bouffet, E; Frappaz, D1
Hijiya, N; Ise, T; Kanagawa, S; Kitabayashi, T; Matsushita, T; Yamaguchi, M1
Baum, ES; Bleyer, WA; Ertel, IJ; Fryer, CJ; Hammond, GD; Krailo, M; Makley, JT; Weetman, RM; Yunis, EJ1
Bielack, S; Erttmann, R; Landbeck, G3
Baldwin, RW; Garnett, MC1
Boyd, JC; Mifflin, TE; Swanson, S1
Cortes Funes, H; Mouridsen, HT; Mulder, JH; Somers, R; Sylvester, R; Thomas, D; van Oosterom, AT; Wagener, DJ1
Bacci, G; Campanacci, M; Gherlinzoni, F; Manfrini, M; Normand, AR; Orlandi, M; Picci, P; Pignatti, G; Van Horn, JR1
Embleton, MJ1
Koczorek, GE; Schalhorn, A; Wilmanns, W1
Yamawaki, S1
Huguet, P; Lafuerza, A; Navarro, M; Pedragosa, R; Rubio, D1
Tomita, K; Yokogawa, A1
Kato, K1
Allen, JC; Caparros, B; Rosen, G; Walker, RW1
Brenes-Sáenz, A; García, I; Lobo-Sanahuja, F; Orlich, F; Vargas, G1
Feurer, EJ; Harris, MB; Johnson, J; Jones, R; Lahman, E; Lewis, M; Sherry, H; Weiner, MA1
Baldwin, RW; Embleton, MJ; Garnett, MC; Pimm, MV1
Cangir, A; Jaffe, N; Keifer, R; Robertson, R; Wang, A1
Gasparini, M; Roncoroni, I; Rottoli, L; Tondini, C1
Meadows, AT; Packer, RJ; Rorke, LB; Wizniter, M1
Crom, WR; Goren, MP; Horowitz, ME; Meyer, WH; Wright, RK1
Furuse, K; Maeyama, I; Morimoto, K; Okuno, M; Orito, T1
Higaki, S; Takeyama, S; Tateishi, A1
Bateman, JR; Bull, F; Chlebowski, RT; Irwin, L; Pugh, R; Weiner, JM1
Andersen, JW; Delorey, MJ; Frei, E; Gebhardt, M; Goorin, AM; Jaffe, N; Link, M; Perez-Atayde, A; Watts, H; Wilkinson, RH1
Cano, JP; Carcassonne, Y; Favre, R; Imbert, AM; Lena, N1
Delling, G; Dingeldein, E; Jungbluth, KH; Langendorff, HU; Senokowitsch, R; Wahlig, H1
Biron, P; Bouffet, E; Brunat-Mentigny, M; Frappaz, D; Kassir, A; Latour, JF; Philip, T1
Ariyoshi, H; Harushita, I; Kurita, S; Shinohara, N; Yokoyama, K1
Edmonson, JH1
Benoit, JP; Délépine, G; Goutallier, D; Hagege, G; Hernigou, P; Leroux, P; Thiery, JP; Voisin, MC1
Akkerboom, JC; Goëken, LN; Kamps, WA; Oosterhuis, JW; Postma, A; Schraffordt Koops, H; Veth, RP1
Fujimoto, T; Hara, K; Matsuoka, H; Murakami, T; Niwa, J; Sasaki, K; Sawai, K; Takayanagi, F1
Baldwin, RW; Blackhall, NW; Byers, VS; Embleton, MJ; Lee, HM; Scannon, P1
Tomita, K1
Ayala, A; Cangir, A; Carrasco, H; Eftekhari, F; Jaffe, N; Raymond, K; Robertson, R; Spears, R; Takaue, Y; Wallace, S1
Fujii, Y; Hongo, T; Horikoshi, Y; Ichimura, M; Igarashi, Y; Mizuno, Y; Sugie, H; Sugie, Y1
Bacci, G; Biagini, R; Capanna, R; Gherlinzoni, F; Guerra, A; Jaffe, N; Picci, P; Ruggieri, P; Toni, A; Van Horn, JR1
Goto, M; Ishii, S; Isu, K; Kobayash, M; Sasaki, T; Ubayama, Y; Usui, M; Yagi, T; Yamawaki, S1
Kelaridis, T; Pongracz, N; Ritschl, P1
Diddens, H; Niethammer, D; Teufel, T1
Bruner, J; Fields, WS; Glass, JP; Lee, YY1
Lampkin, BC; Wong, KY1
Bruno, R; Cano, JP; Favre, R; Iliadis, A; Imbert, AM; Lena, N1
Galicich, JH; Huvos, AG; Rosen, G; Sundaresan, N1
Moe, PJ; Nygaard, R; Vik, T1
Cohen, MD; Mail, JT; Mirkin, LD; Provisor, AJ1
Ayala, A; Cangir, A; Carrasco, H; Eftekhari, F; Jaffe, N; Robertson, R; Takaue, Y; Wallace, S; Wang, A1
Anzai, T; Ayala, A; Cangir, A; Chen, T; Chuang, V; Jaffe, N; Robertson, R; Wallace, S; Wang, YM1
Anzai, T; Jaffe, N; Robertson, R; Takaue, Y1
Erttmann, R; Gkanatsas, A1
Kalifa, C; Lemerle, J; Vanel, D1
Coltman, CA; Costanzi, JJ1
Rietberg, M1
Freeman, JE; Malpas, JS1
Cassady, JR; Das, L; Djerassi, I; Farber, S; Frauenberger, G; Geiser, C; Jaffe, N; Kim, BS; Paed, D; Traggis, D1
Beattie, EJ; Kwon, C; Murphy, ML; Rosen, G; Suwansirikul, S; Tan, C; Wu, SJ1
Pratt, CB; Roberts, D; Shanks, EC; Warmath, EL1
Freckman, HA1
Carter, SK; Friedman, MA1
Bishop, Y; Frei, E; Jaffe, N; Traggis, D1
Amiel, JL; Cattan, A; de Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Rosenfeld, C; Schlumberger, JR; Schneider, M; Schwarzenberg, L1
Mahaley, MS; Woodhall, B1

Reviews

77 review(s) available for methotrexate and Osteogenic Sarcoma

ArticleYear
Resource-appropriate selection of osteosarcoma treatment protocols in low- and middle-income countries.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Developing Countries; Humans; Methotrexate; Osteosarcoma; Young Adult

2022
Chemoresistance-Related Stem Cell Signaling in Osteosarcoma and Its Plausible Contribution to Poor Therapeutic Response: A Discussion That Still Matters.
    International journal of molecular sciences, 2022, Sep-27, Volume: 23, Issue:19

    Topics: Adolescent; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Signal Transduction

2022
A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.
    Journal of pediatric hematology/oncology, 2023, 01-01, Volume: 45, Issue:1

    Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis.
    Journal of orthopaedic surgery and research, 2020, Feb-13, Volume: 15, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Leukopenia; Methotrexate; Network Meta-Analysis; Osteosarcoma; Survival Rate; Thrombocytopenia; Treatment Outcome

2020
Future Directions in the Treatment of Osteosarcoma.
    Cells, 2021, 01-15, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Immunotherapy; Male; Medical Oncology; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Precision Medicine; Prognosis; Quality of Life; Treatment Outcome

2021
Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review.
    European journal of pharmacology, 2021, Aug-05, Volume: 904

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Doxorubicin; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Osteosarcoma

2021
Concomitant Administration of High-dose Methotrexate and Low-dose Aspirin Without Any Delay in Methotrexate Clearance in a Patient With Osteosarcoma: A Case Report and Review of the Literature.
    Journal of pediatric hematology/oncology, 2018, Volume: 40, Issue:6

    Topics: Aspirin; Bone Neoplasms; Child; Glomerular Filtration Rate; Humans; Male; Methotrexate; Osteosarcoma

2018
Efficacy of methotrexate, doxorubicin, and cisplatin for osteosarcoma: Study protocol for a systematic review of randomized controlled trial.
    Medicine, 2019, Volume: 98, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Quality of Life; Randomized Controlled Trials as Topic; Research Design

2019
Methotrexate, doxorubicin, and cisplatinum regimen is still the preferred option for osteosarcoma chemotherapy: A meta-analysis and clinical observation.
    Medicine, 2019, Volume: 98, Issue:19

    Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Survival Analysis

2019
Recurrent primary cardiac osteosarcoma: a case report and literature review.
    General thoracic and cardiovascular surgery, 2014, Volume: 62, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Fatal Outcome; Heart Neoplasms; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Reoperation

2014
Analysis of chemotherapy dosage and dosage intensity and survival outcomes of high-grade osteosarcoma patients younger than 40 years.
    Clinical therapeutics, 2014, Apr-01, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Grading; Osteosarcoma; Treatment Outcome

2014
Impaired testicular function after an ifosfamide-containing regimen for pediatric osteosarcoma: a case series and review of the literature.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cohort Studies; Disorder of Sex Development, 46,XY; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Luteinizing Hormone; Male; Methotrexate; Osteosarcoma; Prognosis; Review Literature as Topic; Spermatogenesis; Testis; Testosterone; Young Adult

2014
Historical perspective on the introduction and use of chemotherapy for the treatment of osteosarcoma.
    Advances in experimental medicine and biology, 2014, Volume: 804

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Routes; Drug Administration Schedule; History, 20th Century; History, 21st Century; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome

2014
The role of chemotherapy for metastatic, relapsed and refractory osteosarcoma.
    Paediatric drugs, 2014, Volume: 16, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Deoxycytidine; Docetaxel; Etoposide; Gemcitabine; Humans; Ifosfamide; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Taxoids

2014
An update on chemotherapy for osteosarcoma.
    Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:18

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic

2015
Pharmacogenomics of genes involved in antifolate drug response and toxicity in osteosarcoma.
    Expert opinion on drug metabolism & toxicology, 2017, Volume: 13, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Folic Acid Antagonists; Humans; Methotrexate; Neoplasm Grading; Osteosarcoma; Pemetrexed; Pharmacogenetics; Trimetrexate

2017
Methotrexate for high-grade osteosarcoma in children and young adults.
    The Cochrane database of systematic reviews, 2009, Jan-21, Issue:1

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Humans; Methotrexate; Osteosarcoma; Young Adult

2009
Osteosarcoma: review of the past, impact on the future. The American experience.
    Cancer treatment and research, 2009, Volume: 152

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma

2009
Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects.
    The Lancet. Oncology, 2010, Volume: 11, Issue:7

    Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Hearing Loss; Heart Diseases; Humans; Ifosfamide; Infertility; Kidney Diseases; Methotrexate; Neoplasms, Second Primary; Neurotoxicity Syndromes; Osteosarcoma; Survivors

2010
Methotrexate for high-grade osteosarcoma in children and young adults.
    The Cochrane database of systematic reviews, 2011, May-11, Issue:5

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Humans; Methotrexate; Osteosarcoma; Quality of Life; Young Adult

2011
Anaphylaxis during the first course of high-dose methotrexate: a case report and literature review.
    Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:2

    Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Male; Methotrexate; Osteosarcoma

2012
Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?
    European journal of cancer (Oxford, England : 1990), 2011, Volume: 47, Issue:16

    Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Survival Analysis

2011
Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis.
    Journal of pediatric surgery, 2011, Volume: 46, Issue:10

    Topics: Abdominal Wall; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Calcinosis; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Neoadjuvant Therapy; Organ Sparing Treatments; Osteosarcoma; Radiography; Razoxane; Receptor, IGF Type 1; Skin Neoplasms; Subcutaneous Tissue; Tibia; Time Factors; Young Adult

2011
The activity of the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group.
    Japanese journal of clinical oncology, 2012, Volume: 42, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease-Free Survival; Doxorubicin; Extremities; Feasibility Studies; Gene Expression Profiling; Humans; Ifosfamide; Japan; Medical Oncology; Methotrexate; Multicenter Studies as Topic; Neoplasm Staging; Osteosarcoma; Perioperative Period; Practice Guidelines as Topic; Research Design; Societies, Medical; Soft Tissue Neoplasms; Survival Analysis; Treatment Outcome

2012
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

    Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine

2003
[Progress and stagnation in chemotherapy protocols for primary osteosarcoma].
    Annales de medecine interne, 2003, Volume: 154, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Multicenter Studies as Topic; Neoadjuvant Therapy; Osteosarcoma; Preoperative Care; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis

2003
High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma.
    Cancer, 2004, May-15, Volume: 100, Issue:10

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Kidney; Methotrexate; Osteosarcoma; Renal Dialysis

2004
Osteosarcoma occurring in osteogenesis imperfecta.
    Virchows Archiv : an international journal of pathology, 2004, Volume: 444, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; DNA Mutational Analysis; DNA, Neoplasm; Doxorubicin; Humans; Ifosfamide; Immunohistochemistry; Lung Neoplasms; Male; Methotrexate; Osteogenesis Imperfecta; Osteosarcoma; Radiography, Thoracic; Thigh; Tomography, X-Ray Computed; Treatment Outcome; Tumor Suppressor Protein p53

2004
[Soft tissue sarcoma: postoperative chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Administration Schedule; Humans; Ifosfamide; Melphalan; Mesna; Methotrexate; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine

2004
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
    Pathologica, 2004, Volume: 96, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chondrosarcoma; Combined Modality Therapy; Desmin; Diagnosis, Differential; Fatal Outcome; Female; Fibrosarcoma; Humans; Humerus; Mesenchymoma; Methotrexate; Neoplasm Proteins; Neoplasms, Multiple Primary; Osteolysis; Osteosarcoma; Postoperative Complications; Pulmonary Embolism; Radiography; Rhabdomyosarcoma; Sarcoma, Ewing

2004
Combination of gemcitabine and irinotecan for recurrent metastatic osteogenic sarcoma.
    Clinical advances in hematology & oncology : H&O, 2005, Volume: 3, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Camptothecin; Cisplatin; Combined Modality Therapy; Deoxycytidine; Doxorubicin; Etoposide; Femoral Neoplasms; Gemcitabine; Head and Neck Neoplasms; Humans; Ifosfamide; Irinotecan; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Palliative Care; Salvage Therapy; Scalp; Skin Neoplasms; Thoracotomy

2005
[Neoadjuvant treatment in osteosarcomas].
    Bulletin du cancer, 2006, Volume: 93, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma

2006
[Recent developments in chemotherapy of malignant diseases].
    Wiener klinische Wochenschrift, 1982, Dec-10, Volume: 94, Issue:23

    Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Female; Genetic Techniques; Hodgkin Disease; Hormones; Humans; Immunotherapy; Interferons; Male; Mechlorethamine; Methotrexate; Mitoxantrone; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Nitrosourea Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Receptors, Cell Surface; Tretinoin; Vincristine

1982
Advances in the multimodal primary management of cancer.
    Advances in internal medicine, 1980, Volume: 26

    Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma

1980
[Drug therapy of malignant tumors of the bone and soft tissues].
    Nihon Seikeigeka Gakkai zasshi, 1981, Volume: 55, Issue:12

    Topics: Adolescent; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms

1981
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
    Onkologie, 1981, Volume: 4, Issue:6

    Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma

1981
Chemotherapy in osteosarcoma. Basis for application and antagonism to implementation; early controversies surrounding its implementation.
    Hematology/oncology clinics of North America, 1995, Volume: 9, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Disease-Free Survival; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Randomized Controlled Trials as Topic; Remission Induction; Survival Rate; Treatment Outcome

1995
Osteosarcoma and other tumors of bone.
    Current opinion in oncology, 1995, Volume: 7, Issue:4

    Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Disease-Free Survival; Female; Humans; Male; Methotrexate; Mutation; Osteosarcoma; Prognosis; Tomography; Tumor Suppressor Protein p53

1995
Treatment of osteosarcoma: experience of the Cooperative Osteosarcoma Study Group (COSS).
    Cancer treatment and research, 1993, Volume: 62

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Germany; Humans; Ifosfamide; Immunologic Factors; Interferon-beta; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic; Treatment Outcome; Vincristine

1993
Osteosarcoma of the extremities: chemotherapy experience at Memorial Sloan-Kettering.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; New York; Osteosarcoma; Prognosis; Proportional Hazards Models; Racial Groups; Retrospective Studies; Risk; Survival Rate; Treatment Outcome

1993
Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disarticulation; Doxorubicin; Europe; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome; Vincristine

1993
The European Osteosarcoma Intergroup (E.O.I.) studies 1980-1991.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Europe; Humans; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome

1993
An update of Scandinavian studies of osteosarcoma.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Scandinavian and Nordic Countries; Survival Rate; Treatment Outcome

1993
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Humans; Ifosfamide; Life Tables; Male; Methotrexate; Minnesota; Necrosis; Osteosarcoma; Pilot Projects; Survival Analysis; Treatment Outcome; Vincristine

1993
Neoadjuvant chemotherapy for patients with osteosarcoma: University of Florida studies.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Florida; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Life Tables; Lung Neoplasms; Methotrexate; Osteosarcoma; Survival Analysis; Treatment Outcome

1993
Osteosarcoma: experience of the Tata Memorial Hospital, Bombay, India.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Developing Countries; Doxorubicin; Female; Humans; India; Lung Neoplasms; Male; Methotrexate; Middle Aged; Osteosarcoma; Retrospective Studies; Survival Rate; Treatment Outcome; Vinblastine

1993
An opinion supporting the role of high-dose methotrexate in the treatment of osteosarcoma.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Acidosis, Renal Tubular; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care; Radionuclide Imaging; Retrospective Studies; Salvage Therapy; Thallium Radioisotopes; Treatment Outcome

1993
Anaphylactoid reactions to methotrexate.
    Cancer, 1996, May-15, Volume: 77, Issue:10

    Topics: Adult; Anaphylaxis; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Pruritus; Urticaria

1996
Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma. Analysis of the literature.
    Cancer, 1996, Nov-15, Volume: 78, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Survival Rate

1996
[Methotrexate-leucovorin rescue therapy: pharmacological characteristics and clinical effective use].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:14

    Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Synergism; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Osteosarcoma

1996
Problems and controversies in the management of childhood sarcomas.
    British medical bulletin, 1996, Volume: 52, Issue:4

    Topics: Amputation, Surgical; Antineoplastic Agents; Child; Child, Preschool; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Rhabdomyosarcoma; Sarcoma

1996
Chemotherapy for osteosarcoma and Ewing's sarcoma.
    Acta orthopaedica Scandinavica. Supplementum, 1997, Volume: 273

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Prognosis; Randomized Controlled Trials as Topic; Research Design; Sarcoma, Ewing

1997
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy.
    European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:11

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Combined Modality Therapy; Decision Making; Humans; Methotrexate; Osteosarcoma; Treatment Outcome

1997
The success and failure of multimodal therapy for cancer in children.
    Cancer, 1975, Volume: 35, Issue:1

    Topics: Adolescent; Age Factors; Child; Dactinomycin; Humans; Lymph Node Excision; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Osteosarcoma; Prognosis; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Testicular Neoplasms; Vincristine; Wilms Tumor

1975
Chemotherapy of solid tumors. Recent advances.
    Postgraduate medicine, 1976, Volume: 59, Issue:2

    Topics: Adult; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Child; Cyclophosphamide; Doxorubicin; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunotherapy; Leucovorin; Male; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Prednisone; Rhabdomyosarcoma; Testicular Neoplasms; Thiotepa; Vinblastine; Vincristine

1976
[Therapy of sarcomas].
    Deutsche medizinische Wochenschrift (1946), 1978, Feb-17, Volume: 103, Issue:7

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Cyclophosphamide; Dacarbazine; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Middle Aged; Osteosarcoma; Remission, Spontaneous; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine

1978
[(Management of acute toxicity after high dose methotrexate therapy)].
    Onkologie, 1979, Volume: 2, Issue:6

    Topics: Adolescent; Blood Transfusion; Brain; Dose-Response Relationship, Drug; Female; Fluid Therapy; Furosemide; Humans; Kidney; Leucovorin; Leukopenia; Methotrexate; Osteosarcoma

1979
Progress in the treatment of osteosarcoma.
    The Medical clinics of North America, 1977, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Cell Division; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy; Time Factors

1977
Multidrug chemotherapy in primary treatment of osteosarcoma. An editorial commentary.
    The Journal of bone and joint surgery. American volume, 1976, Volume: 58, Issue:5

    Topics: Amputation, Surgical; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1976
Methotrexate revisited.
    Medical and pediatric oncology, 1976, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine

1976
Dialyzable transfer factor in the treatment of human osteosarcoma: an analytic review.
    Annals of the New York Academy of Sciences, 1976, Volume: 277, Issue:00

    Topics: Animals; Antineoplastic Agents; Biological Assay; Bone Neoplasms; Cell Extracts; Chemical Fractionation; Chemical Phenomena; Chemistry; Cytotoxicity Tests, Immunologic; Dialysis; Doxorubicin; Humans; Immunity, Cellular; Methotrexate; Osteosarcoma; T-Lymphocytes; Transfer Factor; Tuberculin Test

1976
Neoplasms of the shoulder girdle.
    The Orthopedic clinics of North America, 1975, Volume: 6, Issue:2

    Topics: Adult; Amputation, Surgical; Bone Neoplasms; Child; Chondroblastoma; Chondrosarcoma; Cryosurgery; Curettage; Eosinophilic Granuloma; Humans; Humerus; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Scapula; Shoulder

1975
The potential of combined modality approaches for the treatment of malignant bone tumors in children.
    Cancer treatment reviews, 1975, Volume: 2, Issue:1

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Immunotherapy; Infant; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiography; Sarcoma, Ewing

1975
Current therapies in osteosarcoma.
    Cancer treatment reviews, 1975, Volume: 2, Issue:1

    Topics: Adjuvants, Pharmaceutic; Adult; Animals; Bone Neoplasms; Child; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Immunotherapy; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1975
Secondary myelodysplastic syndrome complicating therapy for osteogenic sarcoma.
    Cancer, 1991, Sep-15, Volume: 68, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Methotrexate; Myelodysplastic Syndromes; Osteosarcoma

1991
Local control and survival from the Cooperative Osteosarcoma Study Group studies of the German Society of Pediatric Oncology and the Vienna Bone Tumor Registry.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Austria; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Germany; Humans; Ifosfamide; Interferon Type I; Male; Methotrexate; Osteosarcoma; Registries; Societies, Medical; Survival Rate; Switzerland; Vincristine

1991
Current management, local management, and survival statistics of high-grade osteosarcoma. Experience in Japan.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adult; Aged; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Humans; Japan; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Osteotomy; Survival Analysis; Survival Rate

1991
Osteogenic osteosarcoma: a model of curable disease by multidisciplinary approach of treatment.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1990, Volume: 44, Issue:5

    Topics: Bone Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma

1990
Osteosarcoma--is there a role for oral low-dose methotrexate.
    Cancer investigation, 1989, Volume: 7, Issue:4

    Topics: Administration, Oral; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma

1989
Chemotherapy for the primary treatment of osteosarcoma: population effectiveness over 20 years.
    Lancet (London, England), 1988, Mar-26, Volume: 1, Issue:8587

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Osteosarcoma; Registries; Regression Analysis; United Kingdom

1988
The role of methotrexate in osteosarcoma.
    Journal of the National Cancer Institute, 1988, Jul-06, Volume: 80, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma

1988
[Methotrexate in pediatric hemato-oncology].
    Pediatrie, 1987, Volume: 42, Issue:4

    Topics: Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Nervous System Diseases; Osteosarcoma

1987
Adjuvant therapy in the treatment of osteosarcoma.
    Important advances in oncology, 1986

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Osteosarcoma

1986
Treatment-related leukoencephalopathy. A study of three cases and literature review.
    Medicine, 1986, Volume: 65, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Brain Neoplasms; Cytarabine; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed

1986
Indications for and benefits of intensive therapies in treatment of childhood cancers.
    Cancer, 1986, Jul-15, Volume: 58, Issue:2 Suppl

    Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Etoposide; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Risk; Sarcoma, Ewing

1986
Osteosarcoma: fifteen years later.
    The New England journal of medicine, 1985, Dec-26, Volume: 313, Issue:26

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Leucovorin; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Prostheses and Implants; Random Allocation

1985
The therapy of osteogenic sarcoma: current status and thoughts for the future.
    Journal of surgical oncology, 1972, Volume: 4, Issue:5

    Topics: Age Factors; Aged; Bone Neoplasms; Doxorubicin; Female; Humans; Immunotherapy; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Sex Factors; Time Factors

1972

Trials

130 trial(s) available for methotrexate and Osteogenic Sarcoma

ArticleYear
A phase II trial evaluating the feasibility of adding bevacizumab to standard osteosarcoma therapy.
    International journal of cancer, 2017, 10-01, Volume: 141, Issue:7

    Topics: Adolescent; Amputation, Surgical; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Limb Salvage; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Survival Rate; Time Factors; Vascular Endothelial Growth Factor A; Wound Healing; Young Adult

2017
Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.
    European journal of cancer (Oxford, England : 1990), 2018, Volume: 88

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Diphosphonates; Doxorubicin; Etoposide; Female; France; Humans; Ifosfamide; Imidazoles; Kaplan-Meier Estimate; Male; Methotrexate; Neutropenia; Osteosarcoma; Young Adult; Zoledronic Acid

2018
Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin-Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin.
    The oncologist, 2018, Volume: 23, Issue:7

    Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cross-Over Studies; Doxorubicin; Female; Hearing; Hearing Loss; Humans; Kidney; Male; Methotrexate; Organic Cation Transporter 2; Osteosarcoma; Pantoprazole; Young Adult

2018
A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial.
    Journal of clinical pharmacology, 2018, Volume: 58, Issue:12

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Child; Female; Gene Expression Regulation; Humans; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Osteosarcoma; Polymorphism, Single Nucleotide; Prospective Studies

2018
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort.
    European journal of cancer (Oxford, England : 1990), 2019, Volume: 109

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cohort Studies; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Survival Rate

2019
Addition of Zoledronate to Chemotherapy in Patients with Osteosarcoma Treated with Limb-Sparing Surgery: A Phase III Clinical Trial.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Feb-23, Volume: 25

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; China; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Survival Rate; Zoledronic Acid

2019
Results of API-AI based regimen in osteosarcoma adult patients included in the French OS2006/Sarcome-09 study.
    International journal of cancer, 2020, 01-15, Volume: 146, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Follow-Up Studies; France; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Survival Rate; Young Adult; Zoledronic Acid

2020
Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: a phase II trial in Japan.
    Journal of chemotherapy (Florence, Italy), 2013, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Infant; Infant, Newborn; Japan; Limb Salvage; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome; Young Adult

2013
Combination of 18F-FDG PET/CT and diffusion-weighted MR imaging as a predictor of histologic response to neoadjuvant chemotherapy: preliminary results in osteosarcoma.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Diffusion Magnetic Resonance Imaging; Doxorubicin; Female; Fluorodeoxyglucose F18; Humans; Male; Methotrexate; Middle Aged; Multimodal Imaging; Neoadjuvant Therapy; Osteosarcoma; Pilot Projects; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique; Tomography, X-Ray Computed; Treatment Outcome; Young Adult

2013
Treatment of large osteosarcoma in children: new approach.
    Experimental oncology, 2013, Volume: 35, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Precision Medicine; Treatment Outcome; Ultrasonography, Doppler

2013
High-dose chemotherapy with stem cell rescue in the primary treatment of metastatic and pelvic osteosarcoma: final results of the ISG/SSG II study.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Grading; Neoplasm Metastasis; Osteosarcoma; Pelvic Neoplasms; Pilot Projects; Prognosis; Stem Cell Transplantation; Survival Rate; Young Adult

2014
Experience of pediatric osteosarcoma of the extremity at a single institution in Taiwan: prognostic factors and impact on survival.
    Annals of surgical oncology, 2015, Volume: 22, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Taiwan

2015
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2015, Volume: 26, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Interferon-alpha; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Polyethylene Glycols; Quality of Life; Research Design; Young Adult

2015
Comparative outcome of Thai pediatric osteosarcoma treated with two protocols: the role of high-dose methotrexate (HDMTX) in a single institute experience.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:22

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Dose-Response Relationship, Drug; Etoposide; Extremities; Feasibility Studies; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Maximum Tolerated Dose; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate

2014
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Respons
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Jul-10, Volume: 33, Issue:20

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asia; Australia; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease Progression; Disease-Free Survival; Doxorubicin; Europe; Female; Humans; Interferon alpha-2; Interferon-alpha; Kaplan-Meier Estimate; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Grading; North America; Osteosarcoma; Osteotomy; Polyethylene Glycols; Proportional Hazards Models; Recombinant Proteins; Risk Factors; Time Factors; Treatment Outcome; Young Adult

2015
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients.
    Journal of surgical oncology, 2015, Volume: 112, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate

2015
Assessment of extent of surgical resection of primary high-grade osteosarcoma by treating institutions: A report from the Children's Oncology Group.
    Journal of surgical oncology, 2016, Volume: 113, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cohort Studies; Doxorubicin; Humans; Methotrexate; Middle Aged; Neoplasm Grading; Osteosarcoma; Retrospective Studies; Young Adult

2016
Evaluation of chemotherapy response in osteosarcoma with FDG-PET.
    Annals of nuclear medicine, 2009, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Fluorodeoxyglucose F18; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome; Young Adult

2009
Sex- and age-related chemotherapy toxicity in patients with non-metastatic osteosarcoma.
    Journal of chemotherapy (Florence, Italy), 2009, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Sex Factors; Young Adult

2009
Hyper-alkalinization without hyper-hydration for the prevention of high-dose methotrexate acute nephrotoxicity in patients with osteosarcoma.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:6

    Topics: Acute Kidney Injury; Adolescent; Adult; Alkalosis; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Kidney; Kidney Function Tests; Male; Methotrexate; Osmolar Concentration; Osteosarcoma; Water Intoxication; Young Adult

2010
Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma.
    Advances in medical sciences, 2010, Volume: 55, Issue:2

    Topics: Adolescent; Adult; Alkaline Phosphatase; Antineoplastic Agents; Biomarkers; Child; Child, Preschool; Cisplatin; Collagen Type I; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Male; Methotrexate; Osteocalcin; Osteosarcoma; Young Adult

2010
Addition of pamidronate to chemotherapy for the treatment of osteosarcoma.
    Cancer, 2011, Apr-15, Volume: 117, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Diphosphonates; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Male; Methotrexate; Osteosarcoma; Pamidronate

2011
Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Jun-10, Volume: 30, Issue:17

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Femur; Humans; Humerus; Ifosfamide; Male; Methotrexate; Osteosarcoma; Tibia

2012
Bayesian estimation of methotrexate pharmacokinetic parameters and area under the curve in children and young adults with localised osteosarcoma.
    Clinical pharmacokinetics, 2002, Volume: 41, Issue:13

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bayes Theorem; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Linear Models; Methotrexate; Models, Biological; Osteosarcoma; Retrospective Studies; Software

2002
Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Apr-15, Volume: 21, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Humans; Leucovorin; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Analysis; Treatment Outcome

2003
Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Leg; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Treatment Outcome

2003
Unstratified chemotherapy for non-metastatic osteosarcoma of the extremities in children.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2003, Volume: 102, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Epirubicin; Etoposide; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Statistics, Nonparametric; Survival Analysis; Taiwan; Treatment Outcome

2003
High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma.
    Cancer, 2004, Apr-15, Volume: 100, Issue:8

    Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Ifosfamide; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Treatment Outcome

2004
Glomerular dysfunction, independent of tubular dysfunction, induced by antineoplastic chemotherapy in children.
    Pediatrics international : official journal of the Japan Pediatric Society, 2004, Volume: 46, Issue:5

    Topics: Acute Disease; Adolescent; Albuminuria; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Creatinine; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Glomerular Filtration Rate; Humans; Kidney Tubules; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Proteinuria; Rhabdomyosarcoma; Vincristine

2004
Twenty-year follow-up of osteosarcoma of the extremity treated with adjuvant chemotherapy.
    Journal of chemotherapy (Florence, Italy), 2004, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Morbidity; Osteosarcoma; Risk Factors; Vincristine

2004
Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Mar-20, Volume: 23, Issue:9

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Infant; Male; Methotrexate; Osteosarcoma; Prospective Studies

2005
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Dec-01, Volume: 23, Issue:34

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Follow-Up Studies; Heart Failure; Humans; Ifosfamide; Italy; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Patient Compliance; Prospective Studies; Renal Insufficiency; Scandinavian and Nordic Countries; Treatment Outcome

2005
Metastatic osteosarcoma.
    Cancer, 2006, Jan-15, Volume: 106, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Treatment Outcome

2006
Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: prognostic factors and impact on survival.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Mar-01, Volume: 24, Issue:7

    Topics: Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brazil; Carboplatin; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Epirubicin; Female; Humans; Ifosfamide; Limb Salvage; Lung Neoplasms; Male; Methotrexate; Multivariate Analysis; Orthopedic Procedures; Osteosarcoma; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Survival Analysis; Treatment Outcome

2006
SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients.
    European journal of cancer (Oxford, England : 1990), 2007, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Preoperative Care

2007
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Feb-01, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Infant; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate

2008
Adjuvant chemotherapy in osteosarcoma - effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin. Preliminary results of the COSS 80 study.
    Journal of cancer research and clinical oncology, 1983, Volume: 106 Suppl

    Topics: Adult; Antineoplastic Agents; Bone Neoplasms; Cisplatin; Clinical Trials as Topic; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Interferons; Methotrexate; Osteosarcoma; Preoperative Care; Random Allocation

1983
Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:6

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Humans; Interferon Type I; Male; Methotrexate; Osteosarcoma; Prognosis

1984
Primary osteogenic sarcoma of the femur: a model for the use of preoperative chemotherapy in high risk malignant tumors.
    Cancer investigation, 1984, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Premedication; Prognosis

1984
Newer techniques in cancer chemotherapy.
    Disease-a-month : DM, 1984, Volume: 30, Issue:10

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Cells, Cultured; Child; Cisplatin; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Hepatic Artery; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Mechlorethamine; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Osteosarcoma; Peritoneal Cavity; Pleura

1984
In search of an effective antiemetic: a nusring staff participates in marijuana research.
    Cancer nursing, 1980, Volume: 3, Issue:4

    Topics: Adult; Antiemetics; Attitude of Health Personnel; Clinical Trials as Topic; Double-Blind Method; Dronabinol; Humans; Methotrexate; Nausea; Nurses; Osteosarcoma; Random Allocation; Vomiting

1980
Toxicity associated with combination chemotherapy for osteosarcoma: a report of the cooperative osteosarcoma study (COSS 80).
    Journal of cancer research and clinical oncology, 1983, Volume: 106 Suppl

    Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Agents; Body Weight; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Osteosarcoma

1983
[Clinico-pharmacological studies on the course of high-dose methotrexate therapy in childhood. A retrospective comparison of centers].
    Deutsche medizinische Wochenschrift (1946), 1984, Jan-27, Volume: 109, Issue:4

    Topics: Adolescent; Bone Marrow; Bone Neoplasms; Cancer Care Facilities; Child; Chondrosarcoma; Clinical Trials as Topic; Germany, West; Humans; Methotrexate; Osteosarcoma; Retrospective Studies

1984
A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:3

    Topics: Adult; Amputation, Surgical; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Pilot Projects; Prognosis; Random Allocation

1984
Treatment of patients with metastatic osteogenic sarcoma: a report from the Children's Cancer Study Group.
    Cancer treatment reports, 1984, Volume: 68, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Kidney Diseases; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Neutropenia; Osteosarcoma; Thrombocytopenia; Time Factors; Vincristine

1984
Is it ethical not to conduct a prospectively controlled trial of adjuvant chemotherapy in osteosarcoma?
    Cancer treatment reports, 1982, Volume: 66, Issue:9

    Topics: Antineoplastic Agents; Bone Neoplasms; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Ethics, Medical; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Prospective Studies; Random Allocation; Tomography, X-Ray Computed

1982
[Aggressive cytostatic treatment of osteogenic sarcoma in childhood (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1981, Feb-13, Volume: 106, Issue:7

    Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Vincristine

1981
Methotrexate as adjuvant treatment for primary osteosarcoma.
    The New England journal of medicine, 1980, Sep-11, Volume: 303, Issue:11

    Topics: Bone Neoplasms; Clinical Trials as Topic; Humans; Methotrexate; Osteosarcoma; Postoperative Care

1980
Advances in the multimodal primary management of cancer.
    Advances in internal medicine, 1980, Volume: 26

    Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma

1980
Osteogenic sarcoma studies by the Cancer and Leukemia Group B.
    National Cancer Institute monograph, 1981, Issue:56

    Topics: Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma

1981
Treatment of soft tissue and bone sarcomas: review of studies at the National Cancer Institute.
    National Cancer Institute monograph, 1981, Issue:56

    Topics: Antineoplastic Agents; Bone Neoplasms; Cardiomyopathies; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Methotrexate; National Institutes of Health (U.S.); Osteosarcoma; Prospective Studies; Random Allocation; Sarcoma; Soft Tissue Neoplasms; United States

1981
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
    Onkologie, 1981, Volume: 4, Issue:6

    Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma

1981
The multi-institutional osteosarcoma study: an update.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Life Tables; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; United States

1993
Osteosarcoma in adolescents and young adults: new developments and controversies. The Childrens Cancer Group (CCG) studies.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; United States; Vincristine

1993
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: the recent experience at the Rizzoli Institute.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Actuarial Analysis; Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Extremities; Female; Humans; Italy; Male; Methotrexate; Necrosis; Osteosarcoma; Prognosis; Salvage Therapy; Survival Analysis

1993
Chemotherapy in osteogenic sarcoma: the experience of the Pediatric Department of the Gustave Roussy Institute.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Feasibility Studies; Female; France; Humans; Ifosfamide; Leucovorin; Male; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; Vincristine

1993
Osteosarcoma of the limb: an institutional report of 10 years experience with neoadjuvant chemotherapy and delayed surgery.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Life Tables; Methotrexate; Osteosarcoma; Treatment Outcome; Vincristine

1993
Safety and efficacy of l-leucovorin rescue following high-dose methotrexate for osteosarcoma.
    Medical and pediatric oncology, 1995, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Stereoisomerism

1995
[Fast neutron treatment of osteosarcoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1994, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Chemotherapy, Adjuvant; Child; Cobalt Radioisotopes; Combined Modality Therapy; Fast Neutrons; Female; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Radiotherapy Dosage

1994
Experience of the EORTC Radiotherapy/Chemotherapy Group in osteosarcoma trials.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disarticulation; Doxorubicin; Europe; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome; Vincristine

1993
The European Osteosarcoma Intergroup (E.O.I.) studies 1980-1991.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Europe; Humans; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome

1993
An update of Scandinavian studies of osteosarcoma.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Etoposide; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Scandinavian and Nordic Countries; Survival Rate; Treatment Outcome

1993
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Feasibility Studies; Female; Humans; Ifosfamide; Life Tables; Male; Methotrexate; Minnesota; Necrosis; Osteosarcoma; Pilot Projects; Survival Analysis; Treatment Outcome; Vincristine

1993
Neoadjuvant chemotherapy for patients with osteosarcoma: University of Florida studies.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Florida; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Life Tables; Lung Neoplasms; Methotrexate; Osteosarcoma; Survival Analysis; Treatment Outcome

1993
Influence of adriamycin dose in the outcome of patients with osteosarcoma treated with multidrug neoadjuvant chemotherapy: results of two sequential studies.
    Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Complications

1993
[Effect of high and low doses of methotrexate (MTX) on bone mass in subjects treated for osteosarcoma of the limbs].
    Minerva medica, 1993, Volume: 84, Issue:3

    Topics: Adolescent; Adult; Bone Density; Bone Neoplasms; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma

1993
Intra-arterial versus intravenous cisplatinum (in addition to systemic Adriamycin and high dose methotrexate) in the neoadjuvant treatment of osteosarcoma of the extremities. results of a randomized study.
    Journal of chemotherapy (Florence, Italy), 1996, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Injections, Intra-Arterial; Injections, Intravenous; Male; Methotrexate; Osteosarcoma

1996
Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Extremities; Humans; Methotrexate; Osteosarcoma; Vincristine

1997
The importance of doxorubicin and methotrexate dose intensity in the chemotherapy of osteosarcoma.
    Archives of orthopaedic and trauma surgery, 1996, Volume: 115, Issue:2

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Osteosarcoma; Retrospective Studies; Survival Rate; Treatment Outcome

1996
Long-term follow-up and post-relapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Extremities; Female; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Male; Methotrexate; Osteosarcoma

1997
Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Injections, Intravenous; Leg; Male; Methotrexate; Osteosarcoma; Prognosis; Surgical Procedures, Operative; Treatment Outcome

1997
Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Necrosis; Osteosarcoma; Time Factors; Treatment Outcome

1998
Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma.
    Pediatric nephrology (Berlin, Germany), 1998, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Creatinine; Female; Humans; Ifosfamide; Kidney Diseases; Kidney Function Tests; Male; Methotrexate; Osteosarcoma

1998
Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Leg; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Risk Factors; Survival Analysis; Treatment Outcome

1998
Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Female; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Osteosarcoma; Time Factors

1998
Local host response in osteosarcoma after chemotherapy referred to radiographs, CT, tumour necrosis and patient survival.
    Journal of cancer research and clinical oncology, 1998, Volume: 124, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Infant; Infant, Newborn; Male; Mesna; Methotrexate; Middle Aged; Necrosis; Neoadjuvant Therapy; Osteosarcoma; Predictive Value of Tests; Prognosis; Tomography, X-Ray Computed

1998
Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide.
    Anti-cancer drugs, 1999, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Bone Neoplasms; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prospective Studies

1999
Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience.
    Acta orthopaedica Scandinavica. Supplementum, 1999, Volume: 285

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care; Prognosis; Registries; Scandinavian and Nordic Countries

1999
High-dose methotrexate and HELP [Holoxan (ifosfamide), eldesine (vindesine), platinum]--doxorubicin in non-metastatic osteosarcoma of the extremity: a French multicentre pilot study. Fédération Nationale des Centres de Lutte contre le Cancer and Société F
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; France; Humans; Ifosfamide; Male; Methotrexate; Necrosis; Osteosarcoma; Pilot Projects; Prognosis; Survival Rate; Time Factors; Vindesine

1999
Long-term results after combined modality treatment for non-metastatic osteosarcoma.
    Medical oncology (Northwood, London, England), 1999, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Treatment Outcome

1999
Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1

    Topics: Adult; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Leucovorin; Lung Neoplasms; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma

2000
Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Dec-15, Volume: 18, Issue:24

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Extremities; Female; Fertility; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Osteosarcoma; Patient Compliance; Plastic Surgery Procedures; Postoperative Complications; Radiography; Reoperation; Survival Rate

2000
Received dose and dose-intensity of chemotherapy and outcome in nonmetastatic extremity osteosarcoma. European Osteosarcoma Intergroup.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Dec-15, Volume: 18, Issue:24

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome

2000
A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2001, Volume: 27, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate

2001
Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches.
    Statistics in medicine, 2001, Mar-15, Volume: 20, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Proportional Hazards Models; Risk Assessment

2001
High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: preliminary results of an Italian Sarcoma Group/Scandinavian Sarcoma Group pilot study.
    Journal of chemotherapy (Florence, Italy), 2002, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chondrocytes; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Fibroblasts; Follow-Up Studies; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoadjuvant Therapy; Osteoblasts; Osteosarcoma; Pilot Projects; Preoperative Care; Prognosis; Survival Rate

2002
Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? A study on 570 patients of two consecutive trials of the European Osteosarcoma Intergroup.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Humans; Infant; Infant, Newborn; Methotrexate; Osteosarcoma; Risk Factors; Survival Analysis; Treatment Outcome

2002
Treatment of osteogenic sarcoma. II. Aggressive resection of pulmonary metastases.
    Cancer treatment reports, 1979, Volume: 63, Issue:5

    Topics: Antineoplastic Agents; Bone Neoplasms; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonectomy; Thoracic Surgery; Thorax

1979
Randomized trial of adjuvant chemotherapy in osteogenic osteosarcoma: comparison of altering sequential administrations of high doses of adriamycin, methotrexate, and cyclophosphamide with a 6-month administration of high-dose adriamycin followed by a low
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1978, Volume: 68

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Random Allocation

1978
Delata-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation.
    Annals of internal medicine, 1979, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Antiemetics; Double-Blind Method; Dronabinol; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Osteosarcoma; Placebos; Prospective Studies; Vomiting

1979
Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation.
    Cancer treatment reports, 1979, Volume: 63, Issue:5

    Topics: Adolescent; Adult; Age Factors; BCG Vaccine; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma

1979
Adjuvant therapy for osteosarcoma: preoperative and postoperative treatment.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Care; Preoperative Care; Time Factors

1978
Local en bloc resection for limb preservation.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Joint Prosthesis; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1978
Sequential combination chemotherapy (containing high-dose cyclophosphamide) for metastic osteogenic sarcoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Bone Neoplasms; Child; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
Combination chemotherapy for osteosarcoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Time Factors

1978
High-dose methotrexate in osteogenic sarcoma: a 5-year experience.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Time Factors; Vincristine

1978
Adjuvant chemotherapy for osteogenic sarcoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1978
Adjuvant therapy for nonmetastatic osteogenic sarcoma: an evaluation of transfer factor versus combination chemotherapy.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Bone Neoplasms; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Transfer Factor; Vincristine

1978
Safety of delayed leucovorin "rescue" following high-dose methotrexate in children.
    Medical and pediatric oncology, 1978, Volume: 5, Issue:1

    Topics: Adult; Child; Child, Preschool; Clinical Trials as Topic; Humans; Leucovorin; Methotrexate; Osteosarcoma; Time Factors

1978
Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate.
    Cancer chemotherapy and pharmacology, 1978, Volume: 1, Issue:1

    Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Humans; Infusions, Parenteral; Kinetics; Leucovorin; Leukemia, Lymphoid; Methotrexate; Osteosarcoma; Time Factors

1978
Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity: a 6 year report.
    Tumori, 1979, Oct-31, Volume: 65, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Recurrence; Vincristine

1979
[Results of chemotherapy of osteosarcoma].
    Nowotwory, 1979, Volume: Suppl

    Topics: Adolescent; Adult; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Femoral Neoplasms; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Vincristine

1979
Progress in the treatment of osteosarcoma.
    The Medical clinics of North America, 1977, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Cell Division; Child; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy; Time Factors

1977
Transfer factor versus combination chemotherapy: a preliminary report of a randomized postsurgical adjuvant treatment study in osteogenic sarcoma.
    Annals of the New York Academy of Sciences, 1976, Volume: 277, Issue:00

    Topics: Antineoplastic Agents; B-Lymphocytes; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Humans; Hypersensitivity, Delayed; Lymphocyte Activation; Methotrexate; Osteosarcoma; Skin Tests; T-Lymphocytes; Transfer Factor; Vincristine

1976
A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Extremities; Feasibility Studies; Female; Humans; Male; Methotrexate; Osteosarcoma; Patient Compliance; Pilot Projects; Treatment Outcome

1992
Effect of chemotherapy combined with caffeine for osteosarcoma.
    Journal of cancer research and clinical oncology, 1992, Volume: 118, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Caffeine; Calcaneus; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Salvage Therapy; Tibia

1992
Effect of intra-arterial versus intravenous cisplatin in addition to systemic adriamycin and high-dose methotrexate on histologic tumor response of osteosarcoma of the extremities.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prospective Studies

1992
[Effects of hydration on plasma concentrations of methotrexate in patients with osteosarcoma treated with high doses of methotrexate].
    Minerva medica, 1992, Volume: 83, Issue:5

    Topics: Adult; Bone Neoplasms; Child; Extremities; Female; Fluid Therapy; Glucose Solution, Hypertonic; Humans; Infusions, Intravenous; Kidney; Leucovorin; Male; Methotrexate; Osteosarcoma

1992
The treatment of osteosarcoma: present trends. The Scandinavian Sarcoma Group experience.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1992, Volume: 3 Suppl 2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Drug Therapy; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies; Scandinavian and Nordic Countries; Survival Rate

1992
Local control and survival from the Cooperative Osteosarcoma Study Group studies of the German Society of Pediatric Oncology and the Vienna Bone Tumor Registry.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Austria; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Germany; Humans; Ifosfamide; Interferon Type I; Male; Methotrexate; Osteosarcoma; Registries; Societies, Medical; Survival Rate; Switzerland; Vincristine

1991
Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents.
    Medical and pediatric oncology, 1991, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Intraoperative Period; Male; Methotrexate; Osteosarcoma; Prospective Studies; Recurrence; Remission Induction; Sarcoma, Ewing; Vincristine

1991
[Alternative chemotherapy of malignant bone neoplasms in children].
    Problemy medycyny wieku rozwojowego, 1990, Volume: 16

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Organoplatinum Compounds; Osteosarcoma; Sarcoma, Ewing; Vincristine

1990
Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Protocols; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Italy; Methotrexate; Necrosis; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prostheses and Implants; Survival Rate; Telangiectasis

1991
Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86).
    Cancer, 1990, Oct-15, Volume: 66, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma

1990
[The combination treatment of malignant bone tumors using fast neutrons].
    Voprosy onkologii, 1990, Volume: 36, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carubicin; Chondrosarcoma; Chordoma; Combined Modality Therapy; Fast Neutrons; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Survival Rate

1990
Pediatric osteosarcoma: therapeutic strategies, results, and prognostic factors derived from a 10-year experience.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:12

    Topics: Child; Cisplatin; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis

1990
Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:2

    Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Period; Preoperative Care; Prognosis; Random Allocation

1988
[Scintigraphic follow-up of osteosarcoma during neoadjuvant chemotherapy. Results of the cooperative osteosarcoma study of the Society for Pediatric Oncology].
    Nuklearmedizin. Nuclear medicine, 1988, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Multicenter Studies as Topic; Osteosarcoma; Radionuclide Imaging; Technetium Tc 99m Medronate

1988
A trial of chemotherapy in patients with osteosarcoma (a report to the Medical Research Council by their Working Party on Bone Sarcoma.
    British journal of cancer, 1986, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Prognosis; Vincristine

1986
The role of methotrexate in osteosarcoma.
    Journal of the National Cancer Institute, 1988, Jul-06, Volume: 80, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma

1988
Adjuvant therapy of osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:6

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Methotrexate; Osteosarcoma; Random Allocation

1987
A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.
    Medical and pediatric oncology, 1987, Volume: 15, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Clinical Trials as Topic; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Prognosis; Random Allocation; Time Factors; Vincristine

1987
Adjuvant therapy in the treatment of osteosarcoma.
    Important advances in oncology, 1986

    Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Humans; Methotrexate; Osteosarcoma

1986
The relationship of various aspects of surgical management to outcome in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.
    Journal of pediatric surgery, 1988, Volume: 23, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radius; Random Allocation; Tibia; Vincristine

1988
High-dose methotrexate in osteosarcoma--Mayo Clinic studies.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis

1987
Adriamycin-methotrexate high dose versus adriamycin-methotrexate moderate dose as adjuvant chemotherapy for osteosarcoma of the extremities: a randomized study.
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Evaluation; Extremities; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Random Allocation

1986
Comparison of intra-arterial cis-diamminedichloroplatinum II with high-dose methotrexate and citrovorum factor rescue in the treatment of primary osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Humans; Infusions, Intra-Arterial; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Random Allocation

1985
Osteosarcoma: fifteen years later.
    The New England journal of medicine, 1985, Dec-26, Volume: 313, Issue:26

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Leucovorin; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Prostheses and Implants; Random Allocation

1985
[Chemotherapy of osteogenic sarcoma].
    Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 1985, Volume: 71, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma

1985
Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma.
    The New England journal of medicine, 1974, Nov-07, Volume: 291, Issue:19

    Topics: Amputation, Surgical; Bone Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Femoral Neoplasms; Follow-Up Studies; Humans; Injections, Intramuscular; Injections, Intravenous; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Time Factors; Vincristine

1974

Other Studies

721 other study(ies) available for methotrexate and Osteogenic Sarcoma

ArticleYear
TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner.
    BMC cancer, 2021, Nov-11, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Methotrexate; Mice; Osteosarcoma; Response Evaluation Criteria in Solid Tumors; STAT1 Transcription Factor; Succinate Dehydrogenase; Transforming Growth Factor beta; Up-Regulation; Warburg Effect, Oncologic; Xenograft Model Antitumor Assays

2021
Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model.
    Anticancer research, 2022, Volume: 42, Issue:2

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carbon-Sulfur Lyases; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2022
Risk Factors for Hepatic Toxicity of High-dose Methotrexate in Patients With Osteosarcoma.
    Anticancer research, 2022, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Female; History, 21st Century; Humans; Japan; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Young Adult

2022
Unexpected severe hepatic and skin toxicities during high dose methotrexate course for osteosarcoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:6

    Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Osteosarcoma; Renal Insufficiency; Stevens-Johnson Syndrome

2022
Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study.
    Asian Pacific journal of cancer prevention : APJCP, 2022, Feb-01, Volume: 23, Issue:2

    Topics: Adolescent; Amputation, Surgical; Antineoplastic Agents; Asia, Southeastern; Bone Neoplasms; Child; Female; Humans; Limb Salvage; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Socioeconomic Factors; Treatment Outcome

2022
Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223.
    Drug research, 2022, Volume: 72, Issue:4

    Topics: Adolescent; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Polycomb Repressive Complex 1; Proto-Oncogene Proteins c-bcl-2; Quercetin; Tumor Suppressor Protein p53

2022
Thymoquinone Augments Methotrexate-Induced Apoptosis on Osteosarcoma Cells.
    Drug research, 2022, Volume: 72, Issue:4

    Topics: Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Bone Neoplasms; Caspase 9; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2

2022
Polydopamine-modified ZIF-8 nanoparticles as a drug carrier for combined chemo-photothermal osteosarcoma therapy.
    Colloids and surfaces. B, Biointerfaces, 2022, Volume: 216

    Topics: Bone Neoplasms; Doxorubicin; Drug Carriers; Drug Liberation; Humans; Indoles; Methotrexate; Nanoparticles; Osteosarcoma; Phototherapy; Photothermal Therapy; Polymers

2022
Prevalence and management of methotrexate-induced neurotoxicity in pediatric patients with osteosarcoma: a single-center experience.
    International journal of clinical oncology, 2022, Volume: 27, Issue:8

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Prevalence; Retrospective Studies; Young Adult

2022
Nomogram predicting leukopenia in osteosarcoma after high-dose methotrexate chemotherapy.
    Aging, 2022, 05-31, Volume: 14, Issue:12

    Topics: Bone Neoplasms; Female; Humans; Ki-67 Antigen; Leukopenia; Methotrexate; Nomograms; Osteosarcoma

2022
Thymoquinone Potentiates Methotrexate Mediated-Apoptosis in Saos-2 Osteosarcoma Cell Line.
    Drug research, 2022, Volume: 72, Issue:7

    Topics: Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2

2022
Osteosarcoma and causes of death: A report of 1520 deceased patients from the Cooperative Osteosarcoma Study Group (COSS).
    European journal of cancer (Oxford, England : 1990), 2022, Volume: 176

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cause of Death; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma

2022
Establishment and Characterization of Single and Triple-Agent Resistant Osteosarcoma Cell Lines.
    Advanced biology, 2023, Volume: 7, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Humans; Methotrexate; Osteosarcoma

2023
LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway.
    Journal of orthopaedic surgery and research, 2022, Dec-21, Volume: 17, Issue:1

    Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Pseudogenes; RNA, Long Noncoding

2022
Peri-osteosarcoma adipose computed tomography attenuation and volume for predicting chemotherapy response in pediatric patients.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2023, Volume: 25, Issue:6

    Topics: Bone Neoplasms; Child; Humans; Inflammation; Methotrexate; Osteosarcoma; Retrospective Studies; Tomography

2023
Neurocognitive outcomes of children with osteosarcoma treated with methotrexate.
    Pediatrics international : official journal of the Japan Pediatric Society, 2023, Volume: 65, Issue:1

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Methotrexate; Osteosarcoma

2023
Predicting chemosensitivity based on mini patient-derived xenografts in osteosarcoma patients: A retrospective study.
    Journal of cancer research and therapeutics, 2023, Volume: 19, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Heterografts; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Retrospective Studies

2023
Effect of co-medications and potential risk factors of high-dose methotrexate-mediated acute hepatotoxicity in patients with osteosarcoma.
    Cancer medicine, 2023, Volume: 12, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Disease Progression; Female; Humans; Methotrexate; Osteosarcoma; Proton Pump Inhibitors; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination

2023
Outcomes and survival rates of childhood osteosarcoma in Iran, A report from MAHAK Pediatric Cancer Treatment and Research Center, from 2007 to 2020.
    Journal of cancer research and therapeutics, 2023, Volume: 19, Issue:Supplement

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Iran; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Survival Rate

2023
A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy.
    The Annals of pharmacotherapy, 2020, Volume: 54, Issue:1

    Topics: Cysteine; Drug Combinations; Drug Interactions; Drug Monitoring; Female; Glycine; Glycyrrhetinic Acid; Humans; Leukemia; Logistic Models; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Vincristine

2020
Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma.
    Pediatric blood & cancer, 2020, Volume: 67, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors

2020
Combinational delivery of anticancer drugs for osteosarcoma treatment using electrosprayed core shell nanocarriers.
    Journal of materials science. Materials in medicine, 2020, May-04, Volume: 31, Issue:5

    Topics: Antineoplastic Agents; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Methotrexate; Nanostructures; Osteosarcoma

2020
Impact of chemotherapy-induced necrosis on event-free and overall survival after preoperative MAP chemotherapy in patients with primary high-grade localized osteosarcoma.
    The bone & joint journal, 2020, Volume: 102-B, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Correlation of Data; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Necrosis; Neoadjuvant Therapy; Osteosarcoma; Preoperative Period; Retrospective Studies; Survival Rate; Young Adult

2020
Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS.
    Aging, 2020, 07-24, Volume: 12, Issue:14

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; GTP Phosphohydrolases; Humans; Membrane Proteins; Methotrexate; MicroRNAs; Neoplasm Invasiveness; Osteosarcoma; RNA, Circular

2020
Methotrexate-induced epidermal necrosis in a child with osteosarcoma.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2020, Volume: 18, Issue:9

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Humans; Male; Methotrexate; Necrosis; Osteosarcoma

2020
miR-192 enhances sensitivity of methotrexate drug to MG-63 osteosarcoma cancer cells.
    Pathology, research and practice, 2020, Volume: 216, Issue:11

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Signal Transduction

2020
Clinical factors affecting prognosis of limb osteosarcoma in China: a multicenter retrospective analysis.
    The Journal of international medical research, 2020, Volume: 48, Issue:8

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; China; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Young Adult

2020
Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an osteosarcoma patient.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:4

    Topics: Adolescent; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Piperacillin; Renal Insufficiency

2021
IAP Chemotherapy Regimen Is a Viable and Cost-effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival.
    Journal of pediatric hematology/oncology, 2021, 05-01, Volume: 43, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cost-Benefit Analysis; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Salvage Therapy

2021
Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis.
    Journal of orthopaedic surgery and research, 2021, Jan-13, Volume: 16, Issue:1

    Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; GTP-Binding Proteins; Humans; Methotrexate; MicroRNAs; Molecular Targeted Therapy; Osteosarcoma; Protein Glutamine gamma Glutamyltransferase 2; RNA, Circular; Transglutaminases

2021
The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma.
    Scientific reports, 2021, 01-21, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteoclasts; Osteosarcoma; Osteotomy; Risk Factors; Tumor Microenvironment; Young Adult

2021
Clinical therapeutic effects of combined methotrexate and other chemotherapeutic agents in treating children and young patients with osteosarcoma: A protocol for systematic review and meta-analysis.
    Medicine, 2021, Apr-30, Volume: 100, Issue:17

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Male; Meta-Analysis as Topic; Methotrexate; Osteosarcoma; Randomized Controlled Trials as Topic; Research Design; Systematic Reviews as Topic; Treatment Outcome; Young Adult

2021
Effect assessment of methotrexate in combination with other chemotherapeutic agents for osteosarcoma in children: A protocol for systematic review and meta-analysis.
    Medicine, 2021, May-21, Volume: 100, Issue:20

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Disease-Free Survival; Humans; Meta-Analysis as Topic; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Randomized Controlled Trials as Topic; Survival Rate; Systematic Reviews as Topic; Time Factors

2021
A possible interaction between favipiravir and methotrexate: Drug-induced hepatotoxicity in a patient with osteosarcoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:2

    Topics: Amides; Antiviral Agents; Bone Neoplasms; Chemical and Drug Induced Liver Injury; COVID-19; Humans; Methotrexate; Osteosarcoma; Pharmaceutical Preparations; Pyrazines; RNA, Viral; SARS-CoV-2

2022
Adjuvant and neoadjuvant chemotherapy for osteosarcoma: JCOG Bone and Soft Tissue Tumor Study Group.
    Japanese journal of clinical oncology, 2021, Oct-05, Volume: 51, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Extremities; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Soft Tissue Neoplasms

2021
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:6

    Topics: Adolescent; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; China; Female; Genotype; Humans; Infant; Lymphoma; Lymphoproliferative Disorders; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Osteosarcoma; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
High dose methotrexate containing regimen in pediatric non-metastatic extremity osteosarcoma patients: experience from a tertiary cancer center in India.
    Pediatric hematology and oncology, 2022, Volume: 39, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Extremities; Humans; Methotrexate; Osteosarcoma

2022
Investigating Optimal Chemotherapy Options for Osteosarcoma Patients through a Mathematical Model.
    Cells, 2021, 08-06, Volume: 10, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Clinical Decision-Making; Cytotoxicity, Immunologic; Decision Support Techniques; Dendritic Cells; Doxorubicin; Drug Administration Schedule; HMGB1 Protein; Humans; Interferon-gamma; Lymphocytes, Tumor-Infiltrating; Methotrexate; Models, Theoretical; Osteosarcoma; Patient Selection; Precision Medicine; T-Lymphocytes, Helper-Inducer; Time Factors; Tumor Microenvironment

2021
Effectiveness of nanoencapsulated methotrexate against osteosarcoma cells: in vitro cytotoxicity under dynamic conditions.
    Biomedical microdevices, 2017, Volume: 19, Issue:2

    Topics: Antineoplastic Agents; Capsules; Cell Line, Tumor; Drug Carriers; Humans; Lab-On-A-Chip Devices; Lipids; Methotrexate; Nanostructures; Osteosarcoma

2017
Diffuse Marrow Involvement in Metastatic Osteosarcoma: An Unusual Presentation.
    Journal of oncology practice, 2017, Volume: 13, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed

2017
Poloxamer surface modified trimethyl chitosan nanoparticles for the effective delivery of methotrexate in osteosarcoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; Endocytosis; Humans; Methotrexate; Nanoparticles; Osteosarcoma; Poloxamer

2017
Fertility, Cardiac, and Orthopedic Challenges in Survivors of Adult and Childhood Sarcoma.
    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2017, Volume: 37

    Topics: Adolescent; Adult; Bone Neoplasms; Cancer Survivors; Cardiotoxicity; Child; Cisplatin; Dexrazoxane; Doxorubicin; Female; Humans; Infertility; Male; Methotrexate; Osteosarcoma

2017
The role of the MTHFR C677T polymorphism in methotrexate-induced toxicity in pediatric osteosarcoma patients.
    Pharmacogenomics, 2017, Volume: 18, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Homozygote; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Osteosarcoma; Pharmacogenetics; Polymorphism, Genetic; Retrospective Studies

2017
Perioperative chemotherapy with and without high-dose methotrexate in adult osteosarcoma.
    Anti-cancer drugs, 2017, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Perioperative Care; Retrospective Studies; Young Adult

2017
Methotrexate-F127 conjugated mesoporous zinc hydroxyapatite as an efficient drug delivery system for overcoming chemotherapy resistance in osteosarcoma cells.
    Colloids and surfaces. B, Biointerfaces, 2017, Oct-01, Volume: 158

    Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Delivery Systems; Durapatite; Humans; Hydrogen-Ion Concentration; Methotrexate; Osteosarcoma; Polyethylenes; Polypropylenes; Zinc

2017
Transition from Tumor Tissue to Bone Marrow in Patients with Appendicular Osteosarcoma after Neoadjuvant Chemotherapy.
    Chinese medical journal, 2017, Sep-20, Volume: 130, Issue:18

    Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; In Vitro Techniques; Limb Salvage; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Treatment Outcome; Young Adult

2017
Outcomes in non-metastatic treatment naive extremity osteosarcoma patients treated with a novel non-high dosemethotrexate-based, dose-dense combination chemotherapy regimen 'OGS-12'.
    European journal of cancer (Oxford, England : 1990), 2017, Volume: 85

    Topics: Adolescent; Adult; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Developing Countries; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; India; Intention to Treat Analysis; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Proportional Hazards Models; Retrospective Studies; Time Factors; Treatment Outcome; Tumor Burden; Young Adult

2017
Patient-derived osteosarcoma cells are resistant to methotrexate.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Bone Neoplasms; Cell Culture Techniques; Cells, Cultured; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Transplantation; Osteosarcoma; Young Adult

2017
Ambulatory High-dose Methotrexate Administration in Pediatric Osteosarcoma Patients at a Single Institution in Argentina.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:7

    Topics: Adolescent; Algorithms; Ambulatory Care; Anemia; Antacids; Argentina; Chemical and Drug Induced Liver Injury; Child; Diarrhea; Female; Humans; Hydrogen-Ion Concentration; Leucovorin; Leukopenia; Male; Methotrexate; Mucositis; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia; Vomiting

2017
MicroRNA-375 as a potential serum biomarker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma.
    The Journal of international medical research, 2018, Volume: 46, Issue:3

    Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Case-Control Studies; Child; Doxorubicin; Female; Humans; Male; Methotrexate; MicroRNAs; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Prognosis; ROC Curve; Survival Analysis; Treatment Outcome; Tumor Burden

2018
Ceramic core with polymer corona hybrid nanocarrier for the treatment of osteosarcoma with co-delivery of protein and anti-cancer drug.
    Nanotechnology, 2018, 01-05, Volume: 29, Issue:1

    Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cattle; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Durapatite; Methotrexate; Nanoparticles; Osteosarcoma; Polyvinyl Alcohol; Serum Albumin, Bovine

2018
Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis.
    Biochemical and biophysical research communications, 2018, 01-01, Volume: 495, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Osteosarcoma; RNA, Long Noncoding; Signal Transduction; Treatment Outcome

2018
Delayed Methotrexate Clearance Despite Carboxypeptidase-G2 (Glucarpidase) Administration in 2 Patients With Toxic Methotrexate Levels.
    Journal of pediatric hematology/oncology, 2018, Volume: 40, Issue:2

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma; Recombinant Proteins

2018
Micrometastatic Drug Screening Platform Shows Heterogeneous Response to MAP Chemotherapy in Osteosarcoma Cell Lines.
    Clinical orthopaedics and related research, 2018, Volume: 476, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Methotrexate; Neoplasm Micrometastasis; Osteosarcoma

2018
S-phase kinase-associated protein 2 is involved in epithelial-mesenchymal transition in methotrexate-resistant osteosarcoma cells.
    International journal of oncology, 2018, Volume: 52, Issue:6

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Osteosarcoma; S-Phase Kinase-Associated Proteins; Signal Transduction

2018
Successful Treatment of Osteosarcoma Without Methotrexate in a 13-Year-Old Boy With Down Syndrome.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:1

    Topics: Adolescent; Bone Neoplasms; Down Syndrome; Humans; Male; Methotrexate; Osteosarcoma

2019
Positive effects of antitumor drugs in combination with propolis on canine osteosarcoma cells (spOS-2) and mesenchymal stem cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 104

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carboplatin; Cell Line, Tumor; Cell Survival; Dogs; Doxorubicin; Mesenchymal Stem Cells; Methotrexate; Osteosarcoma; Propolis

2018
The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences.
    BMC cancer, 2018, May-31, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Survival Rate; Treatment Outcome; Young Adult

2018
The Efficiency and Toxicity of Mifamurtide in Childhood Osteosarcoma.
    Journal of pediatric hematology/oncology, 2018, Volume: 40, Issue:6

    Topics: Acetaminophen; Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Methotrexate; Osteosarcoma; Phosphatidylethanolamines; Retrospective Studies; Survival Rate; Turkey

2018
Outpatient High-dose Methotrexate for Osteosarcoma: It's Safe and Feasible, If You Want It.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:5

    Topics: Adolescent; Bone Neoplasms; Hospitalization; Humans; Methotrexate; Osteosarcoma; Outpatients; Patient Satisfaction; Prospective Studies; Treatment Outcome

2019
2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity.
    Clinica chimica acta; international journal of clinical chemistry, 2018, Volume: 487

    Topics: Adult; Female; gamma-Glutamyl Hydrolase; Humans; Hydrolysis; Kidney; Methotrexate; Osteosarcoma; Particle Size; Surface Properties

2018
Outcomes in Treatment-Naïve Patients With Metastatic Extremity Osteosarcoma Treated With OGS-12, a Novel Non-High-Dose Methotrexate-Based, Dose-Dense Combination Chemotherapy, in a Tertiary Care Cancer Center.
    Journal of global oncology, 2018, Volume: 4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Prospective Studies; Retrospective Studies; Survival Rate; Tertiary Healthcare; Treatment Outcome; Young Adult

2018
miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Dec-06, Volume: 24

    Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen Type III; Down-Regulation; Drug Resistance, Neoplasm; Humans; Methotrexate; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Osteosarcoma; Up-Regulation

2018
Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma.
    Journal of clinical pharmacology, 2019, Volume: 59, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Bone Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult

2019
Safety and efficacy of high-dose methotrexate for osteosarcoma in adolescents compared with young adults.
    Cancer medicine, 2019, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Treatment Outcome; Young Adult

2019
Bone Sarcoma With
    International journal of surgical pathology, 2019, Volume: 27, Issue:5

    Topics: 12E7 Antigen; Adult; Amputation, Surgical; Biopsy; Bone Neoplasms; Chemotherapy, Adjuvant; Diagnosis, Differential; Femur; Gene Amplification; Humans; Male; Methotrexate; Oncogene Proteins, Fusion; Osteosarcoma; Sarcoma, Ewing; Treatment Outcome

2019
SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription.
    The FEBS journal, 2019, Volume: 286, Issue:12

    Topics: Animals; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Methotrexate; Mice; Osteosarcoma; Peptide Synthases

2019
Clinical Prognostic Factors and Outcome in Pediatric Osteosarcoma: Effect of Delay in Local Control and Degree of Necrosis in a Multidisciplinary Setting in Lebanon.
    Journal of global oncology, 2019, Volume: 5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Infant; Lebanon; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Retrospective Studies; Risk Assessment; Treatment Outcome

2019
Reversible Impaired Methotrexate Clearance After Platinum-Based Chemotherapy for Osteosarcoma.
    Therapeutic drug monitoring, 2019, Volume: 41, Issue:6

    Topics: Adolescent; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Doxorubicin; Drug Interactions; Female; Humans; Kidney Diseases; Leucovorin; Methotrexate; Morphine; Mucositis; Osteosarcoma

2019
Osteosarcoma around the knee treated with neoadjuvant chemotherapy and a custom-designed prosthesis.
    Orthopedics, 2013, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arthroplasty, Replacement, Knee; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Ifosfamide; Knee; Knee Joint; Knee Prosthesis; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prosthesis Design; Retrospective Studies; Young Adult

2013
The correlation between dose of folinic acid and neurotoxicity in children and adolescents treated for osteosarcoma with high-dose methotrexate (HDMTX): a neuropsychological and psychosocial study.
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Male; Methotrexate; Neuropsychological Tests; Neurotoxicity Syndromes; Osteosarcoma; Young Adult

2013
Carboplatin and doxorubicin in treatment of pediatric osteosarcoma: a 9-year single institute experience in the Northern Region of Thailand.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:2

    Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Retrospective Studies; Risk Factors; Survival; Survival Rate; Thailand; Treatment Outcome

2013
Single nucleotide polymorphisms in the NER pathway and clinical outcome of patients with bone malignant tumors.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Cyclin H; DNA Helicases; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endonucleases; Female; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Neoplasm Metastasis; Nuclear Proteins; Osteosarcoma; Poly-ADP-Ribose Binding Proteins; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prognosis; Survival Rate; Transcription Factors; Young Adult

2013
Simple and reliable HPLC method for the monitoring of methotrexate in osteosarcoma patients.
    Journal of chromatographic science, 2014, Volume: 52, Issue:7

    Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Humans; Limit of Detection; Linear Models; Male; Methotrexate; Middle Aged; Osteosarcoma; Reproducibility of Results; Young Adult

2014
Predictive impact of common variations in DNA repair genes on clinical outcome of osteosarcoma.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; DNA Repair; DNA-Binding Proteins; Doxorubicin; Endonucleases; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Staging; Nuclear Proteins; Osteosarcoma; Polymorphism, Genetic; Prognosis; Transcription Factors; Young Adult

2013
Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells.
    Cancer gene therapy, 2013, Volume: 20, Issue:9

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cloning, Molecular; Gene Expression; Gene Order; Genes, Reporter; Genetic Vectors; Humans; Lentivirus; Methotrexate; Organ Specificity; Osteocalcin; Osteosarcoma; Peptide Synthases; Promoter Regions, Genetic; Transduction, Genetic; Transfection; Tumor Cells, Cultured

2013
Hypersensitivity reaction to high-dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:2

    Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Infusions, Intravenous; Methotrexate; Osteosarcoma; Prognosis

2014
Effect of variation of ABCB1 and ABCC3 genotypes on the survival of bone tumor cases after chemotherapy.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Polymorphism, Single Nucleotide; Prognosis; Survival Rate; Vincristine; Young Adult

2013
Efficacy of glucarpidase (carboxypeptidase g2) in patients with acute kidney injury after high-dose methotrexate therapy.
    Pharmacotherapy, 2014, Volume: 34, Issue:5

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; Compassionate Use Trials; Drug Administration Schedule; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Methotrexate; Osteosarcoma; Treatment Outcome

2014
Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein.
    Chinese medical journal, 2013, Volume: 126, Issue:21

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma

2013
Drug-drug interaction between methotrexate and levetiracetam resulting in delayed methotrexate elimination.
    The Annals of pharmacotherapy, 2014, Volume: 48, Issue:2

    Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Levetiracetam; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Piracetam

2014
Can high dose methotrexate be continued after severe hypersensitivity reaction?
    Pediatric blood & cancer, 2014, Volume: 61, Issue:6

    Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Methotrexate; Osteosarcoma

2014
Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathy.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Female; Hearing Loss; Humans; Ifosfamide; Magnetic Resonance Imaging; Methotrexate; Osteosarcoma

2014
Extraskeletal Osteosarcoma: An International Rare Cancer Network Study.
    American journal of clinical oncology, 2016, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Chemotherapy, Adjuvant; Cisplatin; Cohort Studies; Deoxycytidine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Gemcitabine; Humans; Ifosfamide; Lower Extremity; Male; Methotrexate; Middle Aged; Mitomycin; Multivariate Analysis; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radiotherapy; Rare Diseases; Retroperitoneal Neoplasms; Retrospective Studies; Soft Tissue Neoplasms; Tumor Burden; Young Adult

2016
[Value of ifosfamide in neoadjuvant therapy for osteosarcoma].
    Der Orthopade, 2013, Volume: 42, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma

2013
Is it important to maintain high-dose intensity chemotherapy in the treatment of adults with osteosarcoma?
    Medical oncology (Northwood, London, England), 2014, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Time Factors; Young Adult

2014
Developing population pharmacokinetic parameters for high-dose methotrexate therapy: implication of correlations among developed parameters for individual parameter estimation using the Bayesian least-squares method.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:6

    Topics: Adolescent; Adult; Aged; Bayes Theorem; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Least-Squares Analysis; Lymphoma; Methotrexate; Middle Aged; Models, Statistical; Osteosarcoma; Patient-Specific Modeling; Retrospective Studies; Young Adult

2014
Reticulated hyperpigmentation following chemotherapy for radiation-induced osteosarcoma.
    Journal of the American Academy of Dermatology, 2014, Volume: 71, Issue:1

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Eruptions; Etoposide; Humans; Hyperpigmentation; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasms, Radiation-Induced; Orbital Neoplasms; Osteosarcoma; Triamcinolone

2014
Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells.
    BioMed research international, 2014, Volume: 2014

    Topics: Adaptor Proteins, Signal Transducing; Adolescent; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Humans; Intracellular Signaling Peptides and Proteins; Methotrexate; Neoplasm Proteins; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Tumor Suppressor Protein p53

2014
Targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induces apoptosis of osteosarcoma cells in vitro.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:15

    Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; Humans; Methotrexate; Osteosarcoma; Survival Rate

2014
Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Organic Anion Transporters; Osteosarcoma; Polymorphism, Single Nucleotide; Survival Analysis; Treatment Outcome; Young Adult

2014
Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Daunorubicin; Etoposide; Fluorouracil; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Humans; Integrin alphaVbeta3; Membrane Transport Modulators; Methotrexate; Osteopontin; Osteosarcoma; Phloretin; Up-Regulation

2014
Metabolic markers of MG-63 osteosarcoma cell line response to doxorubicin and methotrexate treatment: comparison to cisplatin.
    Journal of proteome research, 2014, Dec-05, Volume: 13, Issue:12

    Topics: Amino Acids; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Membrane; Choline; Cisplatin; Doxorubicin; Energy Metabolism; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methotrexate; Molecular Structure; Multivariate Analysis; Nucleotides; Osteosarcoma

2014
Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes.
    World journal of surgical oncology, 2014, Nov-11, Volume: 12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Survival Rate; Time Factors

2014
High-dose methotrexate (HD-MTX) used as an adjunct with other chemotherapeutics for the treatment of osteosarcoma.
    Cell biochemistry and biophysics, 2015, Volume: 71, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Child; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Prognosis; Recurrence; Retrospective Studies; Young Adult

2015
Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:4

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Beclin-1; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Humans; Membrane Proteins; Methotrexate; Mice; Osteosarcoma; Signal Transduction; Xenograft Model Antitumor Assays

2015
Pirarubicin versus doxorubicin in neoadjuvant/adjuvant chemotherapy for stage IIB limb high-grade osteosarcoma: does the analog matter?
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Retrospective Studies; Young Adult

2015
Population pharmacokinetics of high-dose methotrexate after intravenous administration in Chinese osteosarcoma patients from a single institution.
    Chinese medical journal, 2015, Jan-05, Volume: 128, Issue:1

    Topics: Adolescent; Adult; Child; Female; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Models, Molecular; Osteosarcoma; Young Adult

2015
Halloysite nanotube-based drug delivery system for treating osteosarcoma.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2014, Volume: 2014

    Topics: Aluminum Silicates; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Clay; Drug Carriers; Humans; Methotrexate; Nanotubes; Osteosarcoma

2014
Excision repair cross-complementation group 1 protein expression predicts survival in patients with high-grade, non-metastatic osteosarcoma treated with neoadjuvant chemotherapy.
    Histopathology, 2015, Volume: 67, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; DNA-Binding Proteins; Doxorubicin; Endonucleases; Female; Humans; Ifosfamide; Immunohistochemistry; Kaplan-Meier Estimate; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Retrospective Studies

2015
Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:9

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Drug Evaluation; Female; gamma-Glutamyl Hydrolase; Hematologic Neoplasms; Humans; Inactivation, Metabolic; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Male; Methotrexate; Osteosarcoma; Recombinant Proteins; Recovery of Function; Retrospective Studies; Young Adult

2015
DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: the same outcome of treatment with different doses in sensitive cell lines.
    Oncology reports, 2015, Volume: 33, Issue:5

    Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Flow Cytometry; Folic Acid Antagonists; Humans; Medulloblastoma; Methotrexate; Osteosarcoma; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase

2015
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate.
    The pharmacogenomics journal, 2015, Volume: 15, Issue:5

    Topics: Alleles; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Osteosarcoma; Polymorphism, Single Nucleotide; Replication Protein C; Tetrahydrofolate Dehydrogenase

2015
Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2015, Volume: 37, Issue:2

    Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Flow Cytometry; Humans; Melatonin; Methotrexate; Osteosarcoma

2015
Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines.
    Journal of orthopaedic surgery and research, 2015, Sep-04, Volume: 10

    Topics: Bone Neoplasms; Cell Line, Tumor; Databases, Genetic; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Protein Interaction Maps

2015
Highly effective reduced toxicity dose-intensive pilot protocol for non-metastatic limb osteogenic sarcoma (SCOS 89).
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Substitution; Etoposide; Female; Follow-Up Studies; Hearing Loss; Humans; Ifosfamide; Kidney Diseases; Leucovorin; Male; Methotrexate; Osteosarcoma; Pilot Projects; Stroke Volume; Survival Rate; Treatment Outcome; Young Adult

2015
Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotonic Agents; Child; Child, Preschool; Cisplatin; Dexrazoxane; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Infant; Infant, Newborn; Male; Methotrexate; Osteosarcoma; Treatment Outcome; Ventricular Dysfunction

2016
Second primary osteosarcomas in patients with retinoblastoma.
    Japanese journal of clinical oncology, 2015, Volume: 45, Issue:12

    Topics: Adolescent; Adult; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Extremities; Female; Genetic Predisposition to Disease; Humans; Infant; Infusions, Intra-Arterial; Japan; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy, Adjuvant; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Risk Factors; Survivors

2015
Risk-Based Therapy for Localized Osteosarcoma.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Femoral Neoplasms; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Stem Cell Transplantation; Treatment Outcome

2016
Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment.
    ACS applied materials & interfaces, 2015, Dec-16, Volume: 7, Issue:49

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Doxorubicin; Humans; Hydrogels; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Xenograft Model Antitumor Assays

2015
Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma.
    JAMA oncology, 2016, Volume: 2, Issue:2

    Topics: Adult; Antimetabolites, Antineoplastic; Attention; Bone Neoplasms; Case-Control Studies; Cognition; Cognition Disorders; Cross-Sectional Studies; Emotions; Executive Function; Female; Humans; Male; Memory; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Osteosarcoma; Quality of Life; Risk Assessment; Risk Factors; Survivors; Time Factors; Treatment Outcome; United States

2016
For Patients With Cancer, Cure Is Not Enough.
    JAMA oncology, 2016, Volume: 2, Issue:2

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cognition; Cognition Disorders; Female; Hospitalization; Humans; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Osteosarcoma; Survivors

2016
Krüppel-like factor 4 promotes high-mobility group box 1-induced chemotherapy resistance in osteosarcoma cells.
    Cancer science, 2016, Volume: 107, Issue:3

    Topics: Antineoplastic Agents; Binding Sites; Bone Neoplasms; Cell Line, Tumor; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Methotrexate; Osteosarcoma; Promoter Regions, Genetic; Protein Binding; Transcription, Genetic

2016
Singapore Cancer Network (SCAN) Guidelines for the Initial Evaluation, Diagnosis, and Management of Extremity Soft Tissue Sarcoma and Osteosarcoma.
    Annals of the Academy of Medicine, Singapore, 2015, Volume: 44, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease Management; Doxorubicin; Extremities; Humans; Ifosfamide; Magnetic Resonance Imaging; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiotherapy; Radiotherapy, Adjuvant; Sarcoma; Singapore; Soft Tissue Neoplasms; Surgical Procedures, Operative; Tomography, X-Ray Computed

2015
Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cytostatic Agents; Drug Screening Assays, Antitumor; Drug Synergism; Energy Metabolism; Enzyme Induction; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lactates; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Molecular Targeted Therapy; Neoplasm Proteins; Osteosarcoma; Ribonucleotides; RNA Interference; Transcription Factors

2016
Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Deoxycytidine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; HEK293 Cells; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Sirolimus

2016
Anti-VEGF-related thrombotic microangiopathy in a child presenting with nephrotic syndrome.
    Pediatric nephrology (Berlin, Germany), 2016, Volume: 31, Issue:6

    Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Male; Methotrexate; Nephrotic Syndrome; Niacinamide; Osteosarcoma; Phenylurea Compounds; Proteinuria; Remission, Spontaneous; Sorafenib; Thrombotic Microangiopathies; Vascular Endothelial Growth Factor A; Withholding Treatment

2016
Elevated ratio of MMP2/MMP9 activity is associated with poor response to chemotherapy in osteosarcoma.
    BMC cancer, 2016, Mar-15, Volume: 16

    Topics: Biopsy; Cisplatin; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; Osteosarcoma; Prognosis; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3

2016
Analytical interference in the therapeutic drug monitoring of methotrexate.
    Annales de biologie clinique, 2016, Jun-01, Volume: 74, Issue:3

    Topics: Adolescent; Bone Neoplasms; Contraindications; Cross Reactions; Drug Monitoring; Drug Substitution; Fluorescence Polarization Immunoassay; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma

2016
Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance.
    Chinese journal of cancer, 2016, May-20, Volume: 35

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Methotrexate; Osteosarcoma; Phosphoproteins; Protein Serine-Threonine Kinases; Signal Transduction; Transcription Factors; YAP-Signaling Proteins

2016
Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Case-Control Studies; Child; Cisplatin; Cohort Studies; Disease-Free Survival; Doxorubicin; Female; gamma-Glutamyl Hydrolase; Genotype; Humans; Ifosfamide; Italy; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Protein 2; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Polymorphism, Genetic; Treatment Outcome; Young Adult

2016
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.
    Oncotarget, 2017, Feb-07, Volume: 8, Issue:6

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Bayes Theorem; Bone Neoplasms; Chi-Square Distribution; Child; Female; gamma-Glutamyl Hydrolase; Genotype; Half-Life; Humans; Male; Metabolic Clearance Rate; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Odds Ratio; Osteosarcoma; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Pregnane X Receptor; Receptors, Steroid; Risk Factors; Treatment Outcome

2017
Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate.
    Journal of experimental & clinical cancer research : CR, 2016, 10-03, Volume: 35, Issue:1

    Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracorporeal Shockwave Therapy; Fluoresceins; Humans; Methotrexate; Osteosarcoma; Receptors, Purinergic P2X7

2016
Delayed High-dose Methotrexate Excretion and Influencing Factors in Osteosarcoma Patients.
    Chinese medical journal, 2016, 11-05, Volume: 129, Issue:21

    Topics: Adolescent; Adult; Age Factors; Child; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Sex Factors; Treatment Outcome; Young Adult

2016
Simultaneous reconstruction of the bone and vessels for complex femoral defect.
    World journal of surgical oncology, 2016, Nov-18, Volume: 14, Issue:1

    Topics: Antineoplastic Agents; Autografts; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Femur; Fibula; Humans; Limb Salvage; Magnetic Resonance Imaging; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Saphenous Vein; Surgical Flaps; Transplantation, Autologous

2016
Ewing Sarcoma of the Bone With EWS/FLI1 Translocation After Successful Treatment of Primary Osteosarcoma.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Femoral Neoplasms; Humans; Ifosfamide; Limb Salvage; Methotrexate; Neoplasms, Second Primary; Oncogene Proteins, Fusion; Osteosarcoma; Proto-Oncogene Protein c-fli-1; Remission Induction; RNA-Binding Protein EWS; Sarcoma, Ewing; Vincristine

2017
In vivo pharmacological evaluation and efficacy study of methotrexate-encapsulated polymer-coated layered double hydroxide nanoparticles for possible application in the treatment of osteosarcoma.
    Drug delivery and translational research, 2017, Volume: 7, Issue:2

    Topics: Aluminum; Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxides; Kidney; Lactic Acid; Liver; Magnesium; Male; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Osteosarcoma; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tumor Burden

2017
ATIC Gene Polymorphism and Histologic Response to Chemotherapy in Pediatric Osteosarcoma.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:5

    Topics: Adenosine; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Osteosarcoma; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Survival Rate; Tetrahydrofolate Dehydrogenase

2017
High-dose methotrexate in adults with osteosarcoma: a population pharmacokinetics study and validation of a new limited sampling strategy.
    Anti-cancer drugs, 2008, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Antimetabolites, Antineoplastic; Bayes Theorem; Body Surface Area; Cost-Benefit Analysis; Creatinine; Drug Monitoring; Female; Forecasting; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Models, Biological; Osteosarcoma; Retrospective Studies; Time Factors

2008
Osteosarcoma: the same old drugs or more?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jun-20, Volume: 26, Issue:18

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Randomized Controlled Trials as Topic

2008
COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclooxygenase 2; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasm Recurrence, Local; Osteosarcoma; Pneumonectomy; Prognosis; Retrospective Studies; Salvage Therapy; Survival Analysis

2008
High-dose methotrexate in osteosarcoma: let the questions surcease--time for final acceptance.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Cycle; Child; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Lung Neoplasms; Methotrexate; Oliguria; Osteosarcoma; Prognosis

2008
Management and successful desensitization in methotrexate-induced anaphylaxis.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:2

    Topics: Anaphylaxis; Child; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Methotrexate; Osteosarcoma

2009
Neoadjuvant chemotherapy with high-dose methotrexate in osteosarcoma.
    The Lancet. Oncology, 2008, Volume: 9, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Drug Administration Schedule; History, 20th Century; Humans; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Treatment Outcome

2008
Population pharmacokinetics of high-dose methotrexate after intravenous administration in pediatric patients with osteosarcoma.
    Therapeutic drug monitoring, 2009, Volume: 31, Issue:1

    Topics: Adolescent; Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Female; Fluorescence Polarization Immunoassay; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Models, Statistical; Osteosarcoma; Reproducibility of Results

2009
Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines.
    Genes, chromosomes & cancer, 2009, Volume: 48, Issue:4

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Comparative Genomic Hybridization; Doxorubicin; Drug Resistance, Neoplasm; Gene Amplification; Gene Dosage; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, Neoplasm; Histone-Lysine N-Methyltransferase; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Myeloid-Lymphoid Leukemia Protein; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Polymerase Chain Reaction; Reproducibility of Results; Tetrahydrofolate Dehydrogenase

2009
Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:12

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Drug Monitoring; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

2008
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression.
    The Journal of pediatrics, 2009, Volume: 154, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Case-Control Studies; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gastrointestinal Diseases; Genotype; Hematologic Diseases; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolate Dehydrogenase

2009
Epithelioid osteosarcoma of the jaw.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Doxorubicin; Epithelioid Cells; Female; Humans; Ifosfamide; Jaw Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome

2009
Treatment of non-metastatic high-grade osteosarcoma (study of 30 cases treated with Scandinavian osteosarcoma protocol XIV and surgery).
    Prilozi, 2008, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Young Adult

2008
High-dose methotrexate: the rationale...
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Delayed renal excretion of methotrexate after a severe anaphylactic reaction to methotrexate in a child with osteosarcoma.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:4

    Topics: Adolescent; Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Methotrexate; Osteosarcoma; Severity of Illness Index

2009
Pulmonary toxocariasis masquerading as metastatic tumor nodules in a child with osteosarcoma.
    Pediatric blood & cancer, 2009, Dec-15, Volume: 53, Issue:7

    Topics: Adolescent; Animals; Antibodies, Helminth; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cattle; Cattle Diseases; Cisplatin; Diagnosis, Differential; Doxorubicin; Food Parasitology; Humans; Humerus; Immunoglobulin G; Larva Migrans, Visceral; Liver; Lung Diseases, Parasitic; Lung Neoplasms; Male; Meat; Methotrexate; Osteosarcoma; Pulmonary Eosinophilia; Toxocariasis

2009
An osteoporotic hip fracture in a 14-year-old girl undergoing chemotherapy and operated for knee osteosarcoma.
    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2009, Volume: 10, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Arthroplasty, Replacement, Knee; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Femur; Fracture Fixation, Internal; Hip Fractures; Humans; Ifosfamide; Immobilization; Magnetic Resonance Imaging; Methotrexate; Osteoporosis; Osteosarcoma; Postoperative Care; Radiography

2009
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells.
    Oncogene, 2009, Nov-19, Volume: 28, Issue:46

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; HCT116 Cells; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Transfection; Tumor Cells, Cultured; Up-Regulation

2009
Glucarpidase rescue in a patient with high-dose methotrexate-induced nephrotoxicity.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2011, Volume: 17, Issue:2

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Drugs, Investigational; Enzyme Therapy; Female; gamma-Glutamyl Hydrolase; Humans; Jordan; Leucovorin; Mandibular Neoplasms; Methotrexate; Osteosarcoma; Treatment Outcome; Vitamin B Complex

2011
Levoleucovorin.
    Oncology (Williston Park, N.Y.), 2008, Volume: 22, Issue:8 Suppl Nu

    Topics: Antineoplastic Agents; Cytoprotection; Humans; Leucovorin; Methotrexate; Osteosarcoma; Vitamin B Complex

2008
High-dose methotrexate is effective in osteosarcoma so what is the problem?
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:12

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Treatment Outcome

2009
Treatment of methotrexate intoxication with various modalities of continuous extracorporeal therapy and glucarpidase.
    Pharmacotherapy, 2010, Volume: 30, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Compassionate Use Trials; Drugs, Investigational; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma; Renal Dialysis; Treatment Outcome

2010
Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis.
    BMC musculoskeletal disorders, 2010, Feb-16, Volume: 11

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Biomarkers; Bone Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Methotrexate; Neoadjuvant Therapy; Neovascularization, Pathologic; Osteosarcoma; Platelet Endothelial Cell Adhesion Molecule-1; Predictive Value of Tests; Prognosis; Retrospective Studies; Vascular Endothelial Growth Factor A; Young Adult

2010
Severe intoxication with methotrexate possibly associated with concomitant use of proton pump inhibitors.
    Anticancer research, 2010, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bone Neoplasms; Child; Child, Preschool; Drug Interactions; gamma-Glutamyl Hydrolase; Humans; Lymphoma; Methotrexate; Middle Aged; Neuroblastoma; Osteosarcoma; Proton Pump Inhibitors; Retrospective Studies; Young Adult

2010
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
    Molecular cancer, 2010, Apr-30, Volume: 9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases

2010
The establishment and characterization of adriamycin-resistant cell lines derived from Saos-2.
    Medical science monitor : international medical journal of experimental and clinical research, 2010, Volume: 16, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Inhibitory Concentration 50; Methotrexate; Osteosarcoma; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles

2010
Anaphylactoid reaction to high-dose methotrexate and successful desensitization.
    Pediatric blood & cancer, 2010, Volume: 55, Issue:3

    Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Desensitization, Immunologic; Female; Humans; Methotrexate; Osteosarcoma; Tibia

2010
Moyamoya in a child treated with interferon for recurrent osteosarcoma.
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:6

    Topics: Antineoplastic Agents; Bone Neoplasms; Carotid Artery Diseases; Cerebral Arterial Diseases; Cerebral Infarction; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Interferon-alpha; Lung Neoplasms; Magnetic Resonance Angiography; Methotrexate; Moyamoya Disease; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Thyroiditis, Autoimmune

2010
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma.
    Journal of chemotherapy (Florence, Italy), 2010, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Survival Rate; Tissue Distribution; Treatment Outcome; Young Adult

2010
Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells.
    PloS one, 2010, Aug-16, Volume: 5, Issue:8

    Topics: Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; IMP Dehydrogenase; Inhibitory Concentration 50; Methotrexate; Mycophenolic Acid; Osteosarcoma

2010
Reduced methotrexate clearance and renal impairment in a boy with osteosarcoma and earlier undetected autosomal dominant polycystic kidney disease (ADPKD).
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:8

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Incidental Findings; Kidney; Male; Methotrexate; Osteosarcoma; Polycystic Kidney, Autosomal Dominant

2010
Ambulatory high-dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost-effective.
    Pediatric blood & cancer, 2010, Dec-15, Volume: 55, Issue:7

    Topics: Adolescent; Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Cost-Benefit Analysis; Costs and Cost Analysis; Female; Home Infusion Therapy; Hospital Charges; Humans; Infusions, Intravenous; Leucovorin; Male; Medically Underserved Area; Methotrexate; Osteosarcoma; Urban Population; Young Adult

2010
Outpatient high-dose methotrexate: proceed with extreme caution, if at all.
    Pediatric blood & cancer, 2010, Dec-15, Volume: 55, Issue:7

    Topics: Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Humans; Methotrexate; Osteosarcoma

2010
Low-dose carboxypeptidase-G2 for methotrexate toxicity in a child.
    Pediatric blood & cancer, 2010, Dec-15, Volume: 55, Issue:7

    Topics: Adolescent; gamma-Glutamyl Hydrolase; Humans; Kidney Diseases; Male; Methotrexate; Osteosarcoma

2010
Skeletal imaging effects of pamidronate therapy in osteosarcoma patients.
    Pediatric radiology, 2011, Volume: 41, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Diphosphonates; Doxorubicin; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Pamidronate; Positron-Emission Tomography; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome

2011
Difficulty measuring methotrexate in a patient with high-dose methotrexate-induced nephrotoxicity.
    Clinical chemistry, 2010, Volume: 56, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma

2010
Commentary.
    Clinical chemistry, 2010, Volume: 56, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma

2010
Commentary.
    Clinical chemistry, 2010, Volume: 56, Issue:12

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bias; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Methotrexate; Osteosarcoma

2010
[Bufalin induces apoptosis in osteosarcoma U-2OS and U-2OS methotrexate 300-resistant cell lines in vitro].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bone Neoplasms; Bufanolides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Tetrahydrofolate Dehydrogenase; Tumor Suppressor Protein p53

2010
Tumor volume increase during preoperative chemotherapy as a novel predictor of local recurrence in extremity osteosarcoma.
    Annals of surgical oncology, 2011, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Preoperative Care; Survival Rate; Treatment Outcome; Tumor Burden; Young Adult

2011
Magnetic resonance imaging is appropriate for determining the osteotomy plane for appendicular osteosarcoma after neoadjuvant chemotherapy.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Combined Modality Therapy; Epirubicin; Female; Follow-Up Studies; Humans; Ifosfamide; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Osteotomy; Preoperative Care; Prognosis; Prospective Studies; Surgery, Computer-Assisted; Survival Rate; Young Adult

2012
Long-term survivals of stage IIb osteosarcoma: a 20-year experience in a single institution.
    Clinics in orthopedic surgery, 2011, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Infant; Kaplan-Meier Estimate; Leucovorin; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Survival Rate; Vincristine; Young Adult

2011
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years.
    Acta orthopaedica, 2011, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Female; Finland; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Norway; Osteosarcoma; Sweden; Treatment Outcome; Young Adult

2011
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma.
    Cancer letters, 2011, Jul-28, Volume: 306, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Immunoenzyme Techniques; Methotrexate; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Osteosarcoma; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Triterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Intracellular drug delivery of layered double hydroxide nanoparticles.
    Journal of nanoscience and nanotechnology, 2011, Volume: 11, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Humans; Hydroxides; Methotrexate; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Nanotechnology; Osteosarcoma; Particle Size

2011
Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt.
    Oncology reports, 2011, Volume: 26, Issue:3

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Membrane Potential, Mitochondrial; Methotrexate; Mitochondria; Osteosarcoma; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quercetin

2011
Enrichment of osteosarcoma stem cells by chemotherapy.
    Chinese journal of cancer, 2011, Volume: 30, Issue:6

    Topics: Animals; Antigens, Surface; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Osteosarcoma; Phenotype; Proto-Oncogene Proteins c-kit

2011
High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients.
    British journal of clinical pharmacology, 2012, Volume: 73, Issue:1

    Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; Sex Factors; Treatment Outcome; Young Adult

2012
Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines.
    Anticancer research, 2011, Volume: 31, Issue:9

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Methotrexate; Osteosarcoma; RNA, Small Interfering

2011
Clinical analysis of Chinese limb osteosarcoma patients treated by two combinations of methotrexate, cisplatin, doxorubicin and ifosfamide.
    Asia-Pacific journal of clinical oncology, 2011, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; China; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Retrospective Studies; Young Adult

2011
The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
    Clinical laboratory, 2011, Volume: 57, Issue:7-8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Bone Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2011
A population pharmacokinetic/pharmacodynamic model of methotrexate and mucositis scores in osteosarcoma.
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:6

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Drug Monitoring; Female; Humans; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Mucositis; Osteosarcoma; Prospective Studies; Severity of Illness Index; Young Adult

2011
Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma.
    Cancer gene therapy, 2012, Volume: 19, Issue:3

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Male; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Osteosarcoma; Receptor, ErbB-2; T-Lymphocytes; Xenograft Model Antitumor Assays

2012
Extraskeletal osteosarcoma of the breast in an adolescent girl.
    Journal of pediatric hematology/oncology, 2012, Volume: 34, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Chondroblastoma; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Methotrexate; Neoplasm Grading; Osteosarcoma; Treatment Outcome

2012
Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells.
    Anti-cancer drugs, 2012, Volume: 23, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Cyclohexanones; Doxorubicin; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Mitotic Index; NF-kappa B; Osteosarcoma; Protein Transport

2012
Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin.
    Anticancer research, 2012, Volume: 32, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Doxorubicin; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma

2012
Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature.
    Journal of pharmacy practice, 2012, Volume: 25, Issue:4

    Topics: Adult; Anti-Ulcer Agents; Drug Interactions; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Omeprazole; Osteosarcoma; Risk

2012
Ifosfamide in the neoadjuvant treatment of osteogenic sarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Jun-10, Volume: 30, Issue:17

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma

2012
Bullous variant of acral erythema in a child after high-dose methotrexate.
    Pediatric hematology and oncology, 2012, Volume: 29, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Hand-Foot Syndrome; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Vitamin B Complex

2012
Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma.
    Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Bone Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Liver; Methotrexate; Osteosarcoma; Retrospective Studies; Treatment Outcome

2012
Clinical monitoring in a patient with Friedreich ataxia and osteogenic sarcoma.
    Journal of child neurology, 2012, Volume: 27, Issue:9

    Topics: Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Neoplasms; Cisplatin; Cohort Studies; Doxorubicin; Female; Frataxin; Friedreich Ataxia; Humans; Immunosuppressive Agents; Iron-Binding Proteins; Male; Methotrexate; Osteosarcoma; Time Factors; Young Adult

2012
[Organ-preserving interventions in combined therapy of children and adolescents with osteosarcoma].
    Voprosy onkologii, 2012, Volume: 58, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Bone Transplantation; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Cohort Studies; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Neoadjuvant Therapy; Orthopedic Procedures; Osteosarcoma; Transplantation, Autologous; Treatment Outcome

2012
Relationship between antimetabolite toxicity and pharmacogenetics in Turkish cancer patients.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alleles; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); DNA; DNA-Binding Proteins; Drug Eruptions; Female; Fluorouracil; Gastrointestinal Neoplasms; Gene Frequency; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minisatellite Repeats; Mucositis; Osteosarcoma; Polymorphism, Genetic; Thymidylate Synthase; Turkey; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein; Young Adult

2012
Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma.
    Clinical orthopaedics and related research, 2012, Volume: 470, Issue:10

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Density; Bone Neoplasms; Child; Female; Humans; Male; Methotrexate; Osteoporosis; Osteosarcoma; Retrospective Studies; Time Factors; Young Adult

2012
Invariant NKT cells increase drug-induced osteosarcoma cell death.
    British journal of pharmacology, 2012, Volume: 167, Issue:7

    Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cells, Cultured; Cisplatin; Doxorubicin; Humans; Immunotherapy, Adoptive; Methotrexate; Natural Killer T-Cells; Osteosarcoma

2012
Preparation and antitumor activity of a polymeric derivative of methotrexate.
    The American journal of the medical sciences, 2012, Volume: 344, Issue:4

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Humans; Methotrexate; Osteosarcoma; Peptides; Polymers

2012
Analysis of prognostic factors in 333 Chinese patients with high-grade osteosarcoma treated by multidisciplinary combined therapy.
    Asia-Pacific journal of clinical oncology, 2013, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Limb Salvage; Male; Methotrexate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Osteosarcoma; Prognosis; Retrospective Studies; Risk Factors; Survival Rate; Young Adult

2013
Targeting hedgehog-GLI-2 pathway in osteosarcoma.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2013, Volume: 31, Issue:3

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Genetic Therapy; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Methotrexate; Nuclear Proteins; Osteoblasts; Osteosarcoma; RNA, Small Interfering; Zinc Finger Protein Gli2

2013
Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cyclophosphamide; Dactinomycin; DNA-Binding Proteins; DNA, Neoplasm; Doxorubicin; Endonucleases; Female; Glutathione S-Transferase pi; Humans; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prognosis; Survival Rate; Vincristine; Xeroderma Pigmentosum Group D Protein; Young Adult

2012
Osteosarcoma of the pelvis: a monoinstitutional experience in patients younger than 41 years.
    Tumori, 2012, Volume: 98, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Methotrexate; Osteosarcoma; Pelvic Bones; Prospective Studies; Radiography; Remission Induction; Treatment Outcome

2012
Pharmacokinetic interaction between high-dose methotrexate and oxacillin.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:4

    Topics: Adolescent; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Drug Interactions; Fatal Outcome; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Oxacillin; Staphylococcal Skin Infections

2002
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Media; Cytarabine; Dialysis; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Fetal Blood; Humans; Hypoxanthine; Methotrexate; Neoplasm Proteins; Nucleotides; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Thymidine; Tumor Cells, Cultured; Vidarabine

2002
Effective removal of methotrexate by high-flux hemodialysis.
    Pediatric nephrology (Berlin, Germany), 2002, Volume: 17, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Fluorescence Polarization Immunoassay; gamma-Glutamyl Hydrolase; Half-Life; Humans; Hypokalemia; Hypophosphatemia; Infusions, Intravenous; Kidney Diseases; Male; Methotrexate; Osteosarcoma; Renal Dialysis; Rhabdomyosarcoma

2002
Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?
    Cancer, 2002, Nov-15, Volume: 95, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Analysis; Treatment Outcome

2002
A pilot study of short-course intensive multiagent chemotherapy in metastatic and axial skeletal osteosarcoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bone Neoplasms; Child; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Ifosfamide; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Pilot Projects; Prognosis; Risk Assessment; Sampling Studies; Survival Analysis; Treatment Outcome

2002
Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:11

    Topics: Adult; Antidotes; Female; gamma-Glutamyl Hydrolase; Humans; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; Treatment Outcome

2002
Successful desensitization to high-dose methotrexate after systemic anaphylaxis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:1

    Topics: Adult; Anaphylaxis; Bone Neoplasms; Desensitization, Immunologic; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Male; Methotrexate; Osteosarcoma

2003
Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Feb-01, Volume: 21, Issue:3

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Arm; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Immunohistochemistry; Leg; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Prognosis; Risk Factors

2003
Use of plasma exchange in methotrexate removal in a patient with osteosarcoma and acute renal insufficiency.
    American journal of hematology, 2003, Volume: 72, Issue:3

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Diuresis; Female; Femoral Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma; Plasma Exchange; Thoracic Neoplasms

2003
Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:4

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Follow-Up Studies; Humans; Ifosfamide; Incidence; Infant, Newborn; Italy; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Oligospermia; Osteosarcoma; Puberty; Semen Preservation; Sperm Count; Surveys and Questionnaires

2003
Acute hypokalemic tetraparesis induced by intravenous methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, May-01, Volume: 21, Issue:9

    Topics: Adult; Antimetabolites, Antineoplastic; Humans; Hypokalemia; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Paresis

2003
Identification of drug-regulated genes in osteosarcoma cells.
    International journal of cancer, 2003, Jul-10, Volume: 105, Issue:5

    Topics: Actinin; Antineoplastic Agents; Apoptosis; Blotting, Northern; Bone Neoplasms; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Ferritins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; IMP Dehydrogenase; Isoenzymes; Methotrexate; Neoplasm Proteins; Nucleic Acid Hybridization; Osteosarcoma; Prohibitins; Protein Biosynthesis; Proteins; Repressor Proteins; rhoA GTP-Binding Protein; Ribonucleotide Reductases; Subtraction Technique; Transfection; Tumor Cells, Cultured

2003
Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, May-15, Volume: 21, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Europe; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Metastasis; Osteosarcoma; Prognosis; Proportional Hazards Models; Survival Analysis; Treatment Outcome

2003
Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders.
    European journal of cancer (Oxford, England : 1990), 2003, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Doxorubicin; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Patient Compliance; Prognosis; Salvage Therapy; Survival Analysis

2003
Long-term survival in osteosarcoma patients following retinoblastoma using doxorubicin, cisplatin, and methotrexate.
    Medical and pediatric oncology, 2003, Volume: 41, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Cisplatin; Doxorubicin; Humans; Humerus; Infant; Male; Methotrexate; Neoplasms, Second Primary; Osteosarcoma; Retinal Neoplasms; Retinoblastoma; Survivors; Tibia

2003
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
    Molecular cancer therapeutics, 2003, Volume: 2, Issue:6

    Topics: Adolescent; Adult; Aged; Carrier Proteins; Cell Cycle Proteins; Child; Child, Preschool; DNA; DNA-Binding Proteins; Drug Resistance, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Female; Humans; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription Factors

2003
OSTEOGENIC SARCOMA IN CHILDHOOD.
    The Medical journal of Australia, 1963, Oct-26, Volume: 2

    Topics: Adolescent; Bone Neoplasms; Child; Humans; Infant; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Osteosarcoma; Radiography; Sarcoma; Surgical Procedures, Operative

1963
DETERMINATIONS OF THE LEVELS OF SERUM FOLATE IN PATIENTS WITH CARCINOMA OF THE HEAD AND NECK TREATED WITH METHOTREXATE.
    Cancer research, 1964, Volume: 24

    Topics: Blood Chemical Analysis; Carcinoma, Squamous Cell; Folic Acid; Humans; Methotrexate; Nasopharyngeal Neoplasms; Neoplasms; Nose Neoplasms; Osteosarcoma; Pathology; Pharmacology; Pharyngeal Neoplasms; Sarcoma; Tongue Neoplasms

1964
OSTEOGENIC SARCOMA OF THE MANDIBLE. REPORT OF CASE TREATED BY RADIATION AND CHEMOTHERAPY.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1964, Volume: 80

    Topics: Bone Neoplasms; Cobalt Isotopes; Dactinomycin; Drug Therapy; Humans; Mandible; Mandibular Neoplasms; Melphalan; Methotrexate; Neoplasms; Osteomyelitis; Osteosarcoma; Pathology; Radiography; Radium; Sarcoma

1964
Progression of osteosarcoma after high-dose methotrexate: over-rescue by folinic acid.
    Pediatric hematology and oncology, 2003, Volume: 20, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Femur; Humans; Ifosfamide; Leucovorin; Methotrexate; Osteosarcoma

2003
Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.
    European journal of cell biology, 2003, Volume: 82, Issue:9

    Topics: Antineoplastic Agents; Bone Neoplasms; Chromosome Aberrations; Chromosomes, Human; Drug Resistance, Neoplasm; Humans; Karyotyping; Membrane Transport Proteins; Methotrexate; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Ploidies; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

2003
Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity.
    Cancer, 2003, Nov-01, Volume: 98, Issue:9

    Topics: Actins; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Carrier Proteins; Child; Drug Resistance, Neoplasm; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured

2003
Preoperative therapy versus immediate surgery in nonmetastatic osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Dec-15, Volume: 21, Issue:24

    Topics: Amputation, Surgical; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Humans; Ifosfamide; Methotrexate; Neoadjuvant Therapy; Osteosarcoma

2003
Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:1

    Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Gene Amplification; Gene Deletion; Gene Expression Regulation, Neoplastic; Hexosyltransferases; Humans; In Vitro Techniques; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Reduced Folate Carrier Protein; Retinoblastoma Protein; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

2004
Methotrexate pharmacokinetics and survival in osteosarcoma.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Survival Rate

2004
Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Separation; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Immunohistochemistry; Inhibitory Concentration 50; Interleukin-12; Membrane Glycoproteins; Methotrexate; Osteosarcoma; RNA, Messenger; Time Factors; Transfection; Up-Regulation

2004
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
    Cancer, 2004, Feb-15, Volume: 100, Issue:4

    Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Carrier Proteins; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured

2004
Layered double hydroxide as an efficient drug reservoir for folate derivatives.
    Biomaterials, 2004, Volume: 25, Issue:15

    Topics: Absorption; Antineoplastic Agents; Biocompatible Materials; Cell Division; Cell Line, Tumor; Drug Delivery Systems; Drug Evaluation; Drug Stability; Fibroblasts; Folic Acid; Humans; Hydroxides; Leucovorin; Macromolecular Substances; Materials Testing; Methotrexate; Molecular Conformation; Osteosarcoma; Pharmaceutical Vehicles

2004
Optimal management of methotrexate intoxication in a child with osteosarcoma.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:3

    Topics: Acute Kidney Injury; Adolescent; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Humans; Male; Methotrexate; Mouth Mucosa; Osteosarcoma; Stomatitis

2004
Low-voltage electrochemotherapy with low-dose methotrexate enhances survival in mice with osteosarcoma.
    Clinical orthopaedics and related research, 2004, Issue:426

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Electroporation; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Osteosarcoma; Survival Rate

2004
[Goal and results of the COSS study].
    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 2004, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Germany; Hand; Humans; Ifosfamide; Methotrexate; Multicenter Studies as Topic; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Patient Care Team; Prognosis; Survival Rate

2004
Tumor excision and reconstruction of the upper cervical spine: a multidisciplinary approach.
    Plastic and reconstructive surgery, 2004, Volume: 114, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Axis, Cervical Vertebra; Bone Transplantation; Cervical Atlas; Chemotherapy, Adjuvant; Chondrosarcoma; Chordoma; Combined Modality Therapy; Cranial Fossa, Posterior; Etoposide; Fatal Outcome; Female; Femoral Neoplasms; Humans; Ifosfamide; Interdisciplinary Communication; Internal Fixators; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Palliative Care; Patient Care Team; Proton Therapy; Remission Induction; Skull Base Neoplasms; Spinal Fusion; Spinal Neoplasms; Surgical Flaps

2004
Low tumor cell density environment yields survival advantage of tumor cells exposed to MTX in vitro.
    Biochimica et biophysica acta, 2005, Jan-18, Volume: 1721, Issue:1-3

    Topics: Adaptation, Physiological; Antimetabolites, Antineoplastic; Cell Count; Cell Survival; Drug Resistance, Neoplasm; HT29 Cells; Humans; Methotrexate; Neoplasms; Osteosarcoma

2005
Long-term survival in high-grade axial osteosarcoma with bone and lung metastases treated with chemotherapy only.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Child, Preschool; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Ifosfamide; Lumbar Vertebrae; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Thoracic Vertebrae; Time Factors; Tomography, X-Ray Computed

2005
Sarcomas of the head and neck. Results from the treatment of 25 patients.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2005, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma; Radiotherapy, Adjuvant; Retrospective Studies; Sarcoma; Surgical Procedures, Operative; Treatment Outcome

2005
Methotrexate levels and outcome in osteosarcoma.
    Pediatric blood & cancer, 2005, Jun-15, Volume: 44, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Female; Humans; Male; Methotrexate; Necrosis; Osteosarcoma; Prognosis; Prospective Studies; Treatment Outcome

2005
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.
    Cancer research, 2005, Mar-01, Volume: 65, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mice; Mice, SCID; Necrosis; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Prognosis; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Survival Rate; Transplantation, Heterologous; Treatment Outcome

2005
Quantitative thallium-201 scintigraphy in childhood osteosarcoma: Comparison with technetuim-99m MDP and magnetic resonance imaging in the evaluation of chemotherapeutic response.
    Pediatric hematology and oncology, 2005, Volume: 22, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Diagnostic Imaging; Doxorubicin; Drug Monitoring; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Radionuclide Imaging; Remission Induction; Technetium Tc 99m Medronate; Thallium Radioisotopes

2005
Acral erythema caused by high-dose methotrexate therapy in patients with osteogenic sarcoma.
    Pediatric hematology and oncology, 2005, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Erythema; Female; Foot; Hand; Humans; Methotrexate; Osteosarcoma; Pain

2005
Methotrexate-induced bullous acral erythema in a child.
    Journal of the American Academy of Dermatology, 2005, Volume: 52, Issue:5 Suppl 1

    Topics: Antimetabolites, Antineoplastic; Child; Erythema; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Skin Diseases, Vesiculobullous

2005
The role of preoperative radiotherapy in nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery.
    International journal of radiation oncology, biology, physics, 2005, Jul-01, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Aged; Amputation, Surgical; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Epirubicin; Extremities; Humans; Ifosfamide; Limb Salvage; Male; Mesna; Methotrexate; Middle Aged; Osteosarcoma; Prognosis; Radiotherapy Dosage; Retrospective Studies; Survival Rate

2005
Prospective evaluation of renal function in pediatric and adult patients treated with high-dose ifosfamide, cisplatin and high-dose methotrexate.
    Anti-cancer drugs, 2005, Volume: 16, Issue:7

    Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney Function Tests; Male; Methotrexate; Osteosarcoma; Prospective Studies

2005
High dose methotrexate in adult patients with osteosarcoma: clinical and pharmacokinetic results.
    Acta oncologica (Stockholm, Sweden), 2005, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Area Under Curve; Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Survival Rate

2005
The classic: recent advances in chemotherapy of metastatic osteogenic sarcoma. 1972.
    Clinical orthopaedics and related research, 2005, Volume: 438

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; History, 20th Century; Humans; Leucovorin; Methotrexate; Orthopedics; Osteosarcoma; Vitamin B Complex

2005
Acute cardiac toxicity associated with high-dose intravenous methotrexate therapy: case report and review of the literature.
    Pharmacotherapy, 2005, Volume: 25, Issue:9

    Topics: Adult; Antimetabolites, Antineoplastic; Bradycardia; Electrocardiography; Fatal Outcome; Female; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Osteosarcoma; Spinal Neoplasms; Tachycardia, Ventricular; Vitamin B Complex

2005
Expression profiles of osteosarcoma that can predict response to chemotherapy.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Nuclear Proteins; Osteosarcoma; Predictive Value of Tests; Prognosis; Razoxane; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Twist-Related Protein 1

2005
Dose intensity of chemotherapy for osteosarcoma and outcome in the Cooperative Osteosarcoma Study Group (COSS) trials.
    Pediatric blood & cancer, 2006, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Ifosfamide; Infant; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Proportional Hazards Models; Retrospective Studies; Survival Analysis

2006
A successful case of allogeneic bone marrow transplantation for osteosarcoma with multiple metastases of lung and bone.
    Bone marrow transplantation, 2006, Volume: 37, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Femoral Neoplasms; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission Induction; Transplantation, Homologous; Treatment Outcome

2006
Fas expression in lung metastasis from osteosarcoma patients.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Dendritic Cells; Doxorubicin; fas Receptor; Humans; Ifosfamide; Lung Neoplasms; Methotrexate; Neoplasm Staging; Osteosarcoma; Paraffin Embedding; Preoperative Care

2005
High energy shock waves enhance the cytotoxic effect of doxorubicin and methotrexate to human osteosarcoma cell lines.
    Oncology reports, 2006, Volume: 15, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; High-Energy Shock Waves; Humans; Methotrexate; Osteosarcoma

2006
Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis.
    Cancer letters, 2006, Feb-08, Volume: 232, Issue:2

    Topics: Apoptosis; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Methotrexate; Osteosarcoma; Tocopherols; Vitamin E

2006
Low-dose methotrexate inhibits lung metastasis and lengthens survival in rat osteosarcoma.
    Clinical & experimental metastasis, 2005, Volume: 22, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Rats; Rats, Inbred F344; Survival Analysis

2005
No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma.
    Anti-cancer drugs, 2006, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Preoperative Care

2006
Cisplatin-induced hypomagnesemia and cardiac dysrhythmia.
    Pediatric blood & cancer, 2007, Volume: 49, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Gastroenteritis; Heart Arrest; Humans; Magnesium; Methotrexate; Osteosarcoma; Water-Electrolyte Imbalance

2007
Clearance of methotrexate by means of hemofiltration in a patient with osteosarcoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:5

    Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; gamma-Glutamyl Hydrolase; Hemofiltration; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Tibia

2006
Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.
    European journal of clinical pharmacology, 2007, Volume: 63, Issue:1

    Topics: Adolescent; Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Monitoring; Female; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma

2007
Neoadjuvant chemotherapy for radioinduced osteosarcoma of the extremity: The Rizzoli experience in 20 cases.
    International journal of radiation oncology, biology, physics, 2007, Feb-01, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Radiation-Induced; Osteosarcoma; Retrospective Studies

2007
Osteosarcoma metastatic to the kidney and iatrogenic hemorrhage.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:3

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Bone Neoplasms; Calcinosis; Camptothecin; Child; Combined Modality Therapy; Doxorubicin; Fatal Outcome; Female; Hematuria; Hemorrhage; Humans; Iatrogenic Disease; Ilium; Irinotecan; Kidney Neoplasms; Lung Neoplasms; Methotrexate; Osteosarcoma; Radiography; Tibia; Ultrasonography, Interventional

2008
p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:3

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Bone Neoplasms; Carcinoma, Squamous Cell; Caspase 3; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mutation; Osteosarcoma; RNA, Small Interfering; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
Limb salvage surgery for osteosarcoma: effective low-cost treatment.
    Clinical orthopaedics and related research, 2007, Volume: 459

    Topics: Adolescent; Adult; Antineoplastic Agents; Arm Bones; Bone Neoplasms; Child; Cohort Studies; Disease-Free Survival; Female; Humans; India; Internal Fixators; Leg Bones; Limb Salvage; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Treatment Outcome

2007
Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bufanolides; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Drug Resistance, Neoplasm; Humans; Methotrexate; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Tetrahydrofolate Dehydrogenase

2007
Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma.
    Cancer research, 2007, Apr-15, Volume: 67, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cisplatin; Doxorubicin; Humans; Immunohistochemistry; Methotrexate; Osteoblasts; Osteosarcoma; RNA, Messenger; Syndecan-2

2007
Chemotherapy for osteosarcoma without high-dose methotrexate: another piece in the puzzle.
    Onkologie, 2007, Volume: 30, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Survival Rate

2007
Chemotherapy for osteosarcoma without high-dose methotrexate: a 12-year follow-up on 53 patients.
    Onkologie, 2007, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Limb Salvage; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Staging; Osteosarcoma; Survival Rate

2007
The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Carrier Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Osteosarcoma; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolates; Xenograft Model Antitumor Assays

2007
Pemetrexed, a multitargeted antifolate drug, demonstrates lower efficacy in comparison to methotrexate against osteosarcoma cell lines.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Folic Acid Antagonists; Glutamates; Guanine; Humans; Immunoblotting; Methotrexate; Osteosarcoma; Pemetrexed; Thymidylate Synthase

2008
Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution.
    Journal of surgical oncology, 2007, Aug-01, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Contraindications; Cyclophosphamide; Dactinomycin; Drug Administration Schedule; Extremities; Female; Humans; Limb Salvage; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Treatment Outcome

2007
Prognosis of radiation-induced bone sarcoma is similar to primary osteosarcoma.
    Clinical orthopaedics and related research, 2007, Volume: 462

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Humans; Ifosfamide; Methotrexate; Middle Aged; Neoplasms, Radiation-Induced; Osteosarcoma; Radionuclide Imaging; Sarcoma; Survival Rate

2007
Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:1

    Topics: Acute Disease; Adolescent; Aminophylline; Antimetabolites, Antineoplastic; Bone Neoplasms; Brain; Child; Diffusion Magnetic Resonance Imaging; Female; Histiocytoma, Malignant Fibrous; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Metabolic Clearance Rate; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2008
Relative tumor burden predicts metastasis-free survival in pediatric osteosarcoma.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Methotrexate; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Staging; Osteosarcoma; Prognosis; Radionuclide Imaging; Retrospective Studies

2008
Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Cohort Studies; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Medical Records; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Radiotherapy Dosage; Retrospective Studies; Risk Factors; Survival Rate

2008
The Memorial Sloan Kettering Cancer Center experience with outpatient administration of high dose methotrexate with leucovorin rescue.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Drug Monitoring; Female; Humans; Infusions, Intravenous; Kidney; Leucovorin; Male; Methotrexate; Neutropenia; Osteosarcoma

2008
Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:3

    Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Collagen; Drug Combinations; Extracellular Matrix; Formazans; Humans; Inhibitory Concentration 50; Karyotyping; Laminin; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Metastasis; Osteosarcoma; Proteoglycans; Tetrazolium Salts; Xenograft Model Antitumor Assays

2008
Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:8

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression; Genes, myc; Humans; Immunohistochemistry; Methotrexate; Oligonucleotides, Antisense; Osteosarcoma; Proto-Oncogene Proteins c-myc; Tetrahydrofolate Dehydrogenase

2008
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
    European journal of cancer care, 2008, Volume: 17, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting

2008
Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study.
    The British journal of oral & maxillofacial surgery, 2008, Volume: 46, Issue:7

    Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Male; Mandibular Neoplasms; Maxillary Neoplasms; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Osteosarcoma; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Young Adult

2008
Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier.
    BMC cancer, 2008, May-01, Volume: 8

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Drug Therapy; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein; RNA, Messenger

2008
[Initial chemotherapy and conservative surgery in the current treatment of osteosarcoma. Apropos of 24 cases].
    Annales de pediatrie, 1984, Oct-15, Volume: 31, Issue:9

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Male; Methods; Methotrexate; Osteosarcoma; Vincristine

1984
[Clinical evaluation on the sensitivity test for anti-cancer agents in malignant bone and soft-tissue tumors].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:9 Suppl

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Resistance; Fluorouracil; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Lymphoma; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Osteosarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Succinate Dehydrogenase; Vincristine

1984
[Dye concentration measurements for the determination of leakage during and following normothermic cytostatic perfusion in the treatment of tumors of the extremities].
    Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR, 1984, Volume: 17, Issue:5

    Topics: Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Histiocytoma, Benign Fibrous; Humans; Indigo Carmine; Indoles; Male; Melanoma; Methotrexate; Osteosarcoma; Soft Tissue Neoplasms; Spectrophotometry; Vincristine

1984
Numerical changes in the various peripheral white blood cells in children as a result of antineoplastic therapy.
    Acta haematologica, 1984, Volume: 72, Issue:5

    Topics: Antineoplastic Agents; Basophils; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Eosinophils; Hodgkin Disease; Humans; Leukocyte Count; Leukocytes; Lymphocytes; Methotrexate; Monocytes; Neuroblastoma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Time Factors; Vincristine; Wilms Tumor

1984
[Combination chemotherapy in osteogenic sarcoma: the Memorial Sloan-Kettering cancer center experience (author's transl)].
    Klinische Padiatrie, 1980, Volume: 192, Issue:2

    Topics: Adolescent; Adult; Bleomycin; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care

1980
The combined effect of interferon and methotrexate on human osteosarcoma and lymphoma cell lines.
    Cancer letters, 1980, Volume: 10, Issue:1

    Topics: Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Humans; Interferons; Lymphoma; Methotrexate; Osteosarcoma

1980
Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.
    Cancer, 1982, Mar-15, Volume: 49, Issue:6

    Topics: Antineoplastic Agents; Bleomycin; Bone Neoplasms; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Time Factors

1982
Lymphocyte capping in muscular dystrophies.
    Brain & development, 1982, Volume: 4, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Immunologic Capping; Infant; Interferons; Leukemia, Myeloid; Lymphocytes; Male; Methotrexate; Middle Aged; Muscular Dystrophies; Osteosarcoma; Subacute Sclerosing Panencephalitis

1982
What has adjuvant chemotherapy of osteosarcoma achieved? Discussion paper.
    Journal of the Royal Society of Medicine, 1983, Volume: 76, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma

1983
Methotrexate and methotrexate polyglutamates in human sarcoma metastases after high-dose methotrexate therapy.
    Klinische Wochenschrift, 1983, Nov-02, Volume: 61, Issue:21

    Topics: Biotransformation; Bone Neoplasms; Dose-Response Relationship, Drug; Humans; Leiomyosarcoma; Lung; Lung Neoplasms; Methotrexate; Osteosarcoma; Peptides; Polyglutamic Acid; Skin; Skin Neoplasms

1983
Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue.
    Biochemical pharmacology, 1984, Sep-01, Volume: 33, Issue:17

    Topics: Chromatography, High Pressure Liquid; Humans; Leucovorin; Methotrexate; Osteosarcoma; Peptides; Polyglutamic Acid

1984
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate

1983
Resistance of human tumor cell lines to antifolates.
    Cancer treatment reviews, 1984, Volume: 11 Suppl A

    Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate

1984
Ferrokinetics after high-dose methotrexate therapy.
    Klinische Wochenschrift, 1981, Oct-01, Volume: 59, Issue:19

    Topics: Carcinoma, Small Cell; Dose-Response Relationship, Drug; Erythropoiesis; Humans; Iron; Kinetics; Lung Neoplasms; Methotrexate; Osteosarcoma; Soft Tissue Neoplasms

1981
[Changes in the management of osteosarcomas of long bones in the Léon Bérard Center, in the last twenty years ].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1982, Jul-08, Volume: 58, Issue:28-29

    Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Extremities; France; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma

1982
[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma; Sodium Bicarbonate

1984
[In vitro cytotoxicity of methotrexate].
    Nihon Seikeigeka Gakkai zasshi, 1984, Volume: 58, Issue:7

    Topics: Animals; Cell Division; Cells, Cultured; Drug Evaluation, Preclinical; Leucovorin; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Time Factors

1984
[Therapeutic response of various histological osteosarcoma subtypes to high-dose methotrexate treatment].
    Onkologie, 1983, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Bone Neoplasms; Female; Femoral Neoplasms; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Tibia

1983
Local control of osteogenic sarcoma by radiation and chemotherapy.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Radiotherapy, High-Energy

1984
Chemotherapy of sarcomas.
    Arizona medicine, 1983, Volume: 40, Issue:1

    Topics: Doxorubicin; Humans; Methotrexate; Osteosarcoma; Sarcoma

1983
[The Zurich experience with preoperative high-dose methotrexate in osteosarcomas].
    Schweizerische medizinische Wochenschrift, 1983, May-07, Volume: 113, Issue:18

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Staging; Osteosarcoma; Premedication; Prognosis

1983
[The use of medium- and high-dose methotrexate in the management of malignant childhood diseases].
    Orvosi hetilap, 1983, Jun-12, Volume: 124, Issue:24

    Topics: Adolescent; Antineoplastic Agents; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leukemia, Myeloid, Acute; Lymphoma; Male; Methotrexate; Osteosarcoma

1983
Angiographic-pathologic comparison in osteosarcoma after presurgical chemotherapy.
    Journal of cancer research and clinical oncology, 1983, Volume: 106 Suppl

    Topics: Adolescent; Adult; Angiography; Bone Neoplasms; Child; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Male; Methotrexate; Osteosarcoma

1983
Adjuvant chemotherapy for osteosarcoma at the Singapore General Hospital.
    Singapore medical journal, 1983, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Singapore; Vincristine

1983
[Comprehensive therapy of osteosarcoma using high doses of methotrexate--experience 1980-1983].
    Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 1983, Volume: 50, Issue:5

    Topics: Adolescent; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma

1983
[Evaluation of severe side effects of high-dose methotrexate in osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Anaphylaxis; Bone Neoplasms; Child; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Nervous System Diseases; Osteosarcoma; Sensation; Vomiting

1984
Osteogenic sarcoma: alterations in the pattern of pulmonary metastases with adjuvant chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors

1983
Transient encephalopathy during the late course of treatment with high-dose methotrexate.
    Cancer, 1984, May-01, Volume: 53, Issue:9

    Topics: Bone Neoplasms; Brain Diseases; Child; Female; Humans; Humerus; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors; Tomography, X-Ray Computed

1984
Antigenicity and drug susceptibility of human osteogenic sarcoma cells "escaping" a cytotoxic methotrexate-albumin-monoclonal antibody conjugate.
    British journal of cancer, 1984, Volume: 49, Issue:5

    Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Cell Line; Drug Resistance; Humans; Methotrexate; Neoplastic Stem Cells; Osteosarcoma; Serum Albumin; Tumor Stem Cell Assay

1984
Preoperative administration of high-dose methotrexate for osteosarcoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1984, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Osteosarcoma

1984
Osteogenic sarcoma of the fourth thoracic vertebra. Long-term survival by chemotherapy only.
    Cancer, 1984, Jun-15, Volume: 53, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Spinal Neoplasms; Thoracic Vertebrae; Vincristine

1984
Potentiation of methotrexate toxicity by dipyridamole.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dipyridamole; DNA Replication; Drug Synergism; Female; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Osteosarcoma; Ovary

1984
Experience in the preparation and experimental use of immunocytostatics.
    Behring Institute Mitteilungen, 1984, Issue:74

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Humans; Methotrexate; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Osteosarcoma; Sarcoma, Experimental; Transplantation, Heterologous; Vinblastine; Vindesine

1984
Adjuvant chemotherapy in osteogenic sarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:10

    Topics: Combined Modality Therapy; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Research Design

1984
[Treatment of osteosarcoma with pre- and postoperative chemotherapy and non-mutilating surgery].
    Revue medicale de Bruxelles, 1984, Volume: 5, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Knee Joint; Knee Prosthesis; Male; Methods; Methotrexate; Osteosarcoma

1984
Analysis of surface antigen expression per cell of human osteogenic sarcoma cells by fluorescence-labelled monoclonal antibodies.
    Archivum immunologiae et therapiae experimentalis, 1984, Volume: 32, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens, Surface; Cell Cycle; Cells, Cultured; DNA, Neoplasm; Flow Cytometry; Fluorescence; Humans; Methotrexate; Mice; Osteosarcoma; RNA, Neoplasm

1984
High-dose methotrexate for osteosarcoma: toxicity and clinical results.
    Oncology, 1983, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Mucous Membrane; Osteosarcoma

1983
High dose systemic methotrexate-associated acute neurologic dysfunction.
    Medical and pediatric oncology, 1983, Volume: 11, Issue:3

    Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Female; Femoral Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed

1983
Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy.
    Journal of cancer research and clinical oncology, 1983, Volume: 106 Suppl

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care; Radiography; Time Factors

1983
Treatment of primary osteosarcoma with intra-arterial and intravenous high-dose methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Leucovorin; Methotrexate; Osteosarcoma

1983
Essential laboratory determinations for monitoring high-dose methotrexate treatment with citrovorum factor rescue.
    Pediatric pharmacology (New York, N.Y.), 1983, Volume: 3, Issue:3-4

    Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Child; Half-Life; Humans; Kidney Function Tests; Leucovorin; Liver Function Tests; Methotrexate; Osteosarcoma

1983
The inability of oral leucovorin to elevate CSF 5-methyl-tetrahydrofolate following high dose intravenous methotrexate therapy.
    Journal of neuro-oncology, 1983, Volume: 1, Issue:1

    Topics: Adolescent; Adult; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Tetrahydrofolates

1983
[EEG-slowing after high-dose Methotrexate with citrovorumfactor-rescue. A spectralanalytic study (author's transl)].
    EEG-EMG Zeitschrift fur Elektroenzephalographie, Elektromyographie und verwandte Gebiete, 1982, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Cerebral Cortex; Child; Electroencephalography; Evoked Potentials; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1982
Multiple-drug chemotherapy for the primary treatment of osteosarcoma of the extremities.
    The Journal of bone and joint surgery. British volume, 1980, Volume: 62-B, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Vincristine

1980
Surgical adjuvant chemotherapy of metastatic murine osteosarcoma.
    International journal of cancer, 1980, Mar-15, Volume: 25, Issue:3

    Topics: Amputation, Surgical; Animals; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Lung Neoplasms; Methotrexate; Mice; Osteosarcoma; Sarcoma, Experimental; Time Factors

1980
Protein-methotrexate-IgG complexes in the serum of patients receiving high-dose antifolate therapy.
    Cancer, 1980, Aug-01, Volume: 46, Issue:3

    Topics: Antigen-Antibody Complex; Breast Neoplasms; Chromatography, Gel; Drug Administration Schedule; Humans; Hypersensitivity, Immediate; Immunization; Immunoglobulin G; Infusions, Parenteral; Methotrexate; Osteosarcoma; Protein Binding

1980
Is amputation necessary for sarcomas? A seven-year experience with limb salvage.
    Annals of surgery, 1980, Volume: 192, Issue:4

    Topics: Adolescent; Adult; Aged; Amputation, Surgical; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Sarcoma; Soft Tissue Neoplasms

1980
Isolation of tumor cells from patients with osteosarcoma and analysis of their sensitivity to methotrexate.
    Cancer research, 1981, Volume: 41, Issue:9 Pt 1

    Topics: Cell Separation; Cells, Cultured; Deoxyuridine; DNA; Drug Resistance; Humans; Hypoxanthines; Lung Neoplasms; Methotrexate; Osteosarcoma; Stimulation, Chemical; Thymidine

1981
The effect of liposome (phospholipid vesicle) entrapment of actinomycin D and methotrexate on the in vivo treatment of sensitive and resistant solid murine tumours.
    European journal of cancer, 1981, Volume: 17, Issue:3

    Topics: Animals; Dactinomycin; Dose-Response Relationship, Drug; Drug Resistance; Female; Liposomes; Methotrexate; Mice; Mice, Inbred AKR; Osteosarcoma; Sarcoma, Experimental; Tissue Distribution

1981
[Results of Primary chemotherapy and Delayed Surgical Resection in Osteosarcoma (author's transl)].
    Wiener klinische Wochenschrift, 1981, Mar-06, Volume: 93, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma

1981
Planning discharge for a patient with osteogenic sarcoma.
    Oncology nursing forum, 1981,Fall, Volume: 8, Issue:4

    Topics: Bone Neoplasms; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Patient Discharge

1981
Adjuvant treatment of osteosarcoma.
    The Surgical clinics of North America, 1981, Volume: 61, Issue:6

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; BCG Vaccine; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma

1981
[Therapeutic results of patients with osteogenic sarcoma by the protocol COSS 77 (author's transl)].
    Unfallheilkunde, 1981, Volume: 84, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Vincristine

1981
High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results.
    Cancer treatment reports, 1981, Volume: 65 Suppl 1

    Topics: Amputation, Surgical; Angiography; Bone Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Extremities; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Time Factors

1981
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
    European journal of cancer & clinical oncology, 1981, Volume: 17, Issue:7

    Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental

1981
Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.
    Cancer treatment reports, 1982, Volume: 66, Issue:9

    Topics: Adolescent; Adult; Bile; Bone Neoplasms; Charcoal; Chromatography, High Pressure Liquid; Gastric Juice; Half-Life; Humans; Infusions, Parenteral; Kinetics; Methotrexate; Middle Aged; Osteosarcoma

1982
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
    Chemotherapy, 1982, Volume: 28, Issue:4

    Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytotoxicity, Immunologic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Lymphocyte Activation; Methotrexate; Neoplasms; Osteosarcoma; Pregnancy; Quinazolines; Sarcoma, Experimental

1982
[Experience with high-dose methotrexate therapy for malignant solid tumors].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Brain Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Glioma; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pons

1982
[A study on the treatment of pulmonary metastatic osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:6

    Topics: Antineoplastic Agents; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Vincristine

1982
Plasma methotrexate as determined by liquid chromatography, enzyme-inhibition assay, and radioimmunoassay after high-dose infusion.
    Clinical chemistry, 1980, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Child; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme Inhibitors; Humans; Infusions, Parenteral; Leucovorin; Methotrexate; Osteosarcoma; Radioimmunoassay

1980
High-dose methotrexate used alone and in combination for measurable primary or metastatic osteosarcoma.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1980
Vincristine in the etiology of toxicity of high-dose methotrexate therapy.
    Cancer, 1980, Dec-15, Volume: 46, Issue:12

    Topics: Adolescent; Dose-Response Relationship, Drug; Drug Combinations; Humans; Infusions, Parenteral; Intestinal Obstruction; Intestine, Large; Leucovorin; Male; Methotrexate; Osteosarcoma; Reflex, Stretch; Vincristine

1980
[High-dose methotrexate with citrovorum factor rescue in osteogenic carcinoma].
    Harefuah, 1980, Volume: 99, Issue:5-6

    Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1980
Normal computed tomograms of the brain in osteosarcoma patients treated with high-dose methotrexate.
    Cancer, 1981, Apr-01, Volume: 47, Issue:7

    Topics: Adolescent; Adult; Brain; Child; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Time Factors; Tomography, X-Ray Computed

1981
[Disturbances of coagulation following high-dosage methotrexate with citrovorum factor rescue in patients with osteogenous sarcoma. (author's transl)].
    Klinische Padiatrie, 1981, Volume: 193, Issue:2

    Topics: Aspartate Aminotransferases; Blood Coagulation Factors; Child; Disseminated Intravascular Coagulation; Female; Heparin; Humans; Leucovorin; Methotrexate; Osteosarcoma

1981
Evaluation of results of new treatments for osteosarcoma.
    International journal of radiation oncology, biology, physics, 1980, Volume: 6, Issue:12

    Topics: Adolescent; Adult; Bone Neoplasms; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis

1980
High-dose methotrexate with a safe rescue program.
    Oncology, 1981, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Female; Humans; Leucovorin; Leukocyte Count; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma

1981
[Risk analysis of the treatment of solid tumors with high dosage methotrexate: apropos of 154 cases].
    Pediatrie, 1981, Volume: 36, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Humans; Kidney; Leucovorin; Lymphoma; Methotrexate; Osteosarcoma; Risk

1981
High-dose methotrexate in osteogenic sarcoma.
    National Cancer Institute monograph, 1981, Issue:56

    Topics: Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Humans; Kinetics; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Vincristine

1981
Prognostic factors in the response of primary osteogenic sarcoma to preoperative chemotherapy (high-dose methotrexate with citrovorum factor).
    National Cancer Institute monograph, 1981, Issue:56

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies

1981
Adjuvant chemotherapy for osteosarcoma: a decade of experience.
    The Surgical clinics of North America, 1981, Volume: 61, Issue:6

    Topics: Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Probability; Time Factors; Vincristine

1981
Adjuvant chemotherapy for primary osteogenic sarcoma.
    The Surgical clinics of North America, 1981, Volume: 61, Issue:6

    Topics: Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Humans; Immunization; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma

1981
Selected applications of methotrexate alone and in combination in osteosarcoma.
    Cancer treatment reports, 1981, Volume: 65 Suppl 1

    Topics: Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis; Vincristine

1981
[H-MTX-CF treatment and osteogenic sarcoma (author's transl)].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1981, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma

1981
Improved three-year disease-free survival in osteogenic sarcoma.
    The Journal of bone and joint surgery. British volume, 1982, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Age Factors; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Sex Factors; Vincristine

1982
Radiographic changes in primary osteogenic sarcoma following intensive chemotherapy. Radiological-pathological correlation in 63 patients.
    Radiology, 1982, Volume: 143, Issue:2

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Radiography

1982
[Studies on the effect of high-dose methotrexate-citrovorum factor treatment for 89Sr induced osteosarcoma in mice (author's transl)].
    Nihon Seikeigeka Gakkai zasshi, 1982, Feb-25, Volume: 56, Issue:2

    Topics: Animals; Drug Therapy, Combination; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred Strains; Osteosarcoma; Sarcoma, Experimental; Strontium Radioisotopes

1982
High-dose methotrexate and adriamycin in osteogenic sarcoma: the children's hospital of Philadelphia study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:1

    Topics: Actuarial Analysis; Adolescent; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1982
Plasma phenylalanine: tyrosine ratios during high-dose methotrexate-citrovorum "rescue".
    Medical and pediatric oncology, 1982, Volume: 10, Issue:4

    Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine

1982
Chemotherapy for osteogenic sarcoma: an investigative method, not a recipe.
    Cancer treatment reports, 1982, Volume: 66, Issue:9

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Economics; Femoral Neoplasms; Humans; Humerus; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Tibia

1982
[New therapeutic results in osteosarcoma].
    Wiener medizinische Wochenschrift (1946), 1982, Jul-31, Volume: 132, Issue:13-14

    Topics: Amputation, Surgical; Bone Neoplasms; Female; Humans; Humerus; Leucovorin; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis

1982
Treatment by amputation and chemotherapy.
    Progress in clinical and biological research, 1982, Volume: 99

    Topics: Amputation, Surgical; BCG Vaccine; Bone Neoplasms; Doxorubicin; Follow-Up Studies; Humans; Leucovorin; Methotrexate; Osteosarcoma

1982
Chemotherapy in osteogenic sarcoma.
    Progress in clinical and biological research, 1982, Volume: 99

    Topics: Bone Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Leucovorin; Melphalan; Methotrexate; Osteosarcoma; Vincristine

1982
[Tissue concentration of methotrexate in osteosarcoma after high-dose infusion].
    Nihon Seikeigeka Gakkai zasshi, 1982, Volume: 56, Issue:8

    Topics: Adolescent; Adult; Animals; Bone Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Tissue Distribution

1982
Adjuvant systemic therapy after ablative surgery for limb osteosarcoma.
    Irish journal of medical science, 1982, Volume: 151, Issue:12

    Topics: Adolescent; Adult; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Postoperative Care

1982
Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT).
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1980, Volume: 18, Issue:3

    Topics: Adult; Aminopterin; Autoanalysis; Costs and Cost Analysis; Female; Humans; Immunoenzyme Techniques; Kinetics; Methotrexate; Neoplasms; Osteosarcoma

1980
Cutaneous pathobiology mediated by chemotherapy.
    Journal of cutaneous pathology, 1980, Volume: 7, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Autoradiography; Bone Neoplasms; Epidermis; Female; Humans; Methotrexate; Middle Aged; Osteosarcoma; Psoriasis; Purpura; Skin; Skin Diseases, Vesiculobullous

1980
[Controlled ultra-high dosage methotrexate therapy in three patients with metastatic osteosarcoma (author's transl)].
    Wiener klinische Wochenschrift, 1981, Apr-03, Volume: 93, Issue:7

    Topics: Adolescent; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunoenzyme Techniques; Leucovorin; Male; Methotrexate; Osteosarcoma; Prognosis

1981
Identification and quantitation of methotrexate and methotrexate metabolites in clinical high-dose therapy by high pressure liquid chromatography and field desorption mass spectrometry.
    Biomedical mass spectrometry, 1982, Volume: 9, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Folic Acid; Humans; Immunoenzyme Techniques; Male; Mass Spectrometry; Methotrexate; Osteosarcoma

1982
Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Oct-24, Volume: 92, Issue:22

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Base Sequence; Bone Neoplasms; Cell Division; Cell Line; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Fibrosarcoma; Floxuridine; Humans; Liposarcoma; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Osteosarcoma; Recombinant Proteins; Retinoblastoma Protein; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transfection; Tumor Cells, Cultured

1995
Osteosarcoma following radiation treatment for meningioma: report of a case and effective treatment with chemotherapy.
    Journal of neuro-oncology, 1994, Volume: 21, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carboplatin; Cisplatin; Dactinomycin; Etoposide; Female; Gonadotropin-Releasing Hormone; Humans; Ifosfamide; Lung Neoplasms; Meningeal Neoplasms; Meningioma; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Osteosarcoma; Tamoxifen; Tomography, X-Ray Computed; Vincristine

1994
Quantitative evaluation of thallium-201 uptake in predicting chemotherapeutic response of osteosarcoma.
    European journal of nuclear medicine, 1995, Volume: 22, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Prospective Studies; Radionuclide Imaging; Thallium Radioisotopes

1995
A monocentric therapy study: an approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Methotrexate; Middle Aged; Osteosarcoma; Pilot Projects; Remission Induction; Salvage Therapy; Treatment Outcome; Vincristine

1993
Osteosarcoma: experience with the Rosen T10 protocol at RCH, Melbourne.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leucovorin; Life Tables; Male; Methotrexate; Osteosarcoma; Survival Rate; Treatment Outcome; Victoria; Vincristine

1993
[Successful treatment with administration of systemic high dose methotrexate and intraarterial carboplatin for osteosarcoma of the skull: a case report].
    No shinkei geka. Neurological surgery, 1995, Volume: 23, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Combined Modality Therapy; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Remission Induction; Skull Neoplasms

1995
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.
    Anti-cancer drugs, 1994, Volume: 5, Issue:4

    Topics: Adolescent; Bone Neoplasms; Dose-Response Relationship, Drug; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma

1994
Osteosarcoma recurrences in pediatric patients previously treated with intensive chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Ifosfamide; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome; Vindesine

1994
Acute urticaria and hepatitis complicating high-dose methotrexate therapy.
    Medical and pediatric oncology, 1995, Volume: 24, Issue:2

    Topics: Acute Disease; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Humans; Methotrexate; Osteosarcoma; Urticaria

1995
Methotrexate pharmacokinetics and prognosis in osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:7

    Topics: Actuarial Analysis; Adolescent; Adult; Child; Child, Preschool; Humans; Methotrexate; Osteosarcoma; Prognosis; Retrospective Studies; Statistics as Topic; Survival Analysis

1994
High-dose methotrexate treatment and liver function in patients with osteosarcoma.
    Journal of internal medicine, 1994, Volume: 236, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Antipyrine; Bone Neoplasms; Cisplatin; Doxorubicin; Female; Galactose; Humans; Liver; Liver Function Tests; Male; Methotrexate; Osteosarcoma; Prospective Studies

1994
Hyperthermic isolated perfusion using cisplatin for treatment of the extremities.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Fibula; Follow-Up Studies; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Male; Methotrexate; Necrosis; Osteosarcoma; Tibia; Tissue Distribution; Treatment Outcome

1993
Diffusion of methotrexate from surgical acrylic cement.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Acrylates; Bone Cements; Bone Neoplasms; Chemotherapy, Adjuvant; Diffusion; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Pharmaceutical Vehicles

1993
Adjuvant interferon treatment in human osteosarcoma.
    Cancer treatment and research, 1993, Volume: 62

    Topics: Bone Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Immunologic Factors; Interferon-alpha; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate

1993
[The importance of dose intensity in preoperative chemotherapy for osteosarcoma--retrospective analysis of a short intensive chemotherapy regimen preoperatively using high-dose methotrexate and cisplatinum].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies; Survival Rate

1994
Cerebral arterial disturbances in a transient encephalopathy induced by methotrexate.
    Medical oncology and tumor pharmacotherapy, 1993, Volume: 10, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cerebral Arteries; Cerebrovascular Circulation; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Humans; Leucovorin; Methotrexate; Osteosarcoma; Seizures; Syndrome

1993
[Long-term follow-up results after heavy dose chemotherapy of primary malignant bone tumors of the limbs].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1993, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Doxorubicin; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Tibia

1993
[Chemotherapy for osteosarcoma--trends in recent years].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:13

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Osteosarcoma

1993
Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin.
    Cancer, 1993, Dec-01, Volume: 72, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Femur; Humans; Humerus; Infusions, Intravenous; Injections, Intra-Arterial; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Complications; Preoperative Care; Remission Induction; Survival Rate; Tibia

1993
Wernicke-encephalopathy in children with cancer.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Ifosfamide; Methotrexate; Osteosarcoma; Tibia; Wernicke Encephalopathy

1994
Impact of omeprazole on the plasma clearance of methotrexate.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:1

    Topics: Adult; Bone Neoplasms; Contraindications; Humans; Male; Metabolic Clearance Rate; Methotrexate; Omeprazole; Osteosarcoma

1993
Proteinuria due to suboptimal hydration with high-dose methotrexate therapy.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:3

    Topics: Adolescent; Bone Neoplasms; Burkitt Lymphoma; Child; Female; Fluid Therapy; Glomerular Filtration Rate; Glucose; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteinuria; Sodium Bicarbonate

1993
Pelvic osteosarcoma: problems in management.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cote d'Ivoire; Cyclophosphamide; Doxorubicin; Fatal Outcome; Female; Health Care Rationing; Humans; Methotrexate; Osteosarcoma; Pelvic Neoplasms; Prednisolone

1994
[A pharmacokinetic study on high-dose methotrexate administration--the effects of volume changes of parenteral solutions on the elimination rate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:1

    Topics: Bone Neoplasms; Female; Humans; Infusions, Parenteral; Mathematics; Methotrexate; Osteosarcoma

1994
Substitution of l-leucovorin for d,l-leucovorin in the rescue from high-dose methotrexate treatment in patients with osteosarcoma.
    Anti-cancer drugs, 1993, Volume: 4, Issue:5

    Topics: Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Humans; Kidney Function Tests; Leucovorin; Leukocyte Count; Liver Function Tests; Methotrexate; Osteosarcoma; Retrospective Studies; Stereoisomerism

1993
Pharmacokinetics of high-dose methotrexate in adult osteogenic sarcoma.
    Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:5

    Topics: Adolescent; Adult; Bayes Theorem; Drug Administration Schedule; Humans; Infusions, Intravenous; Methotrexate; Middle Aged; Osteosarcoma

1994
[32 cases of postoperative osteogenic sarcoma treated by chemotherapy combined with Chinese medicinal herbs].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1993, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Dexamethasone; Drugs, Chinese Herbal; Female; Humans; Male; Methotrexate; Osteosarcoma; Postoperative Period; Vincristine; Vomiting

1993
Pathological responses to preoperative high-dose methotrexate chemotherapy in osteosarcoma--experience in Korea cancer hospital.
    Journal of Korean medical science, 1993, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma

1993
Improved results in osteogenic sarcoma 1973-79 vs. 1980-86: analysis of results from a single center.
    Israel journal of medical sciences, 1993, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Life Expectancy; Male; Methotrexate; Osteosarcoma; Platinum; Prognosis; Survival Analysis; Treatment Outcome

1993
Determination of methotrexate in human urine at nanomolar levels by high-performance liquid chromatography with column switching.
    Journal of chromatography, 1993, Apr-02, Volume: 613, Issue:2

    Topics: Bone Neoplasms; Chromatography, High Pressure Liquid; Freezing; Humans; Indicators and Reagents; Methotrexate; Nursing; Occupational Exposure; Osteosarcoma; Quality Control

1993
Serum methotrexate (MTX) concentrations and prognosis in patients with osteosarcoma of the extremities treated with a multidrug neoadjuvant regimen.
    Journal of chemotherapy (Florence, Italy), 1993, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Etoposide; Extremities; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Prognosis

1993
Targeted delivery of antineoplastic agent to bone: biodistribution studies of technetium-99m-labeled gem-bisphosphonate conjugate of methotrexate.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Bone and Bones; Bone Neoplasms; Diphosphonates; Male; Methotrexate; Mice; Osteosarcoma; Rabbits; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Tissue Distribution

1996
Localized cisplatin hyperpigmentation induced by pressure. A case report.
    Cancer, 1996, Apr-15, Volume: 77, Issue:8

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Hyperpigmentation; Male; Methotrexate; Osteosarcoma; Pressure

1996
High-dose methotrexate-induced bullous variant of acral erythema.
    Archives of dermatology, 1996, Volume: 132, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chondrosarcoma; Erythema; Female; Humans; Methotrexate; Osteosarcoma; Skin Diseases, Vesiculobullous

1996
Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity.
    Cancer, 1995, Aug-01, Volume: 76, Issue:3

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Female; Femoral Neoplasms; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Osteosarcoma

1995
[Current aspects of the treatment of osteogenic sarcoma].
    Klinichna khirurhiia, 1995, Issue:5

    Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Osteosarcoma; Platinum; Time Factors

1995
Long-term pulmonary toxicity of multiagent chemotherapy including bleomycin and cyclophosphamide in osteosarcoma survivors.
    Medical and pediatric oncology, 1996, Volume: 27, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Forced Expiratory Volume; Humans; Lung; Methotrexate; Osteosarcoma; Pulmonary Diffusing Capacity; Total Lung Capacity

1996
Musculoskeletal tumour disorders.
    Comprehensive therapy, 1996, Volume: 22, Issue:1

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Humans; Methotrexate; Necrosis; Osteosarcoma

1996
[Preliminary evaluation of individualized use of large doses of methotrexate for treatment of osteosarcoma in children and adolescents].
    Pediatria polska, 1995, Volume: 70, Issue:11

    Topics: Adolescent; Adult; Child; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Osteosarcoma

1995
[A device for rapid elevation of plasma methotrexate (MTX) concentration and its maintenance in high-dose MTX therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1996, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Female; Fluorescence Polarization Immunoassay; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma

1996
[Preoperative and postoperative chemotherapy of osteogenic sarcoma of the limbs in children].
    Medicina clinica, 1996, Jun-29, Volume: 107, Issue:5

    Topics: Adolescent; Age Factors; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Follow-Up Studies; Humans; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Postoperative Care; Preoperative Care; Survival Rate; Time Factors; Vincristine

1996
[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].
    Minerva pediatrica, 1996, Volume: 48, Issue:5

    Topics: Antineoplastic Agents; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Kidney; Liver; Methotrexate; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia

1996
Methotrexate serum concentration and histological response to multiagent primary chemotherapy for osteosarcoma of the limbs.
    Journal of chemotherapy (Florence, Italy), 1996, Volume: 8, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Prognosis

1996
Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions.
    Cancer, 1997, Jan-15, Volume: 79, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma

1997
Neoadjuvant chemotherapy for pediatric osteosarcoma patients.
    Cancer, 1997, Jan-15, Volume: 79, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Retrospective Studies

1997
Methotrexate osteopathy in patients with osteosarcoma.
    Radiology, 1997, Volume: 202, Issue:2

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Diseases; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Osteosarcoma; Radiography; Retrospective Studies

1997
Prognostic significance of chemotherapy dosage characteristics in children with osteogenic sarcoma.
    Medical and pediatric oncology, 1997, Volume: 28, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Humans; Methotrexate; Multivariate Analysis; Osteosarcoma; Prognosis; Retrospective Studies

1997
[High-dose methotrexate and cerebral neurotoxicity. Apropos of a case of arachnoiditis].
    Presse medicale (Paris, France : 1983), 1997, Mar-01, Volume: 26, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Arachnoiditis; Bone Neoplasms; Encephalitis; Humans; Infusions, Intravenous; Male; Methotrexate; Osteosarcoma; Tibia

1997
Effect of methotrexate and sulphasalazine on UMR 106 rat osteosarcoma cells.
    British journal of rheumatology, 1997, Volume: 36, Issue:2

    Topics: Alkaline Phosphatase; Animals; Antirheumatic Agents; Bone Neoplasms; Cell Count; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Leucovorin; Methotrexate; Osteosarcoma; Rats; Sulfapyridine; Sulfasalazine; Tumor Cells, Cultured; Vitamin D

1997
B7-1-transfected tumor vaccine counteracts chemotherapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells.
    International journal of cancer, 1997, Jun-11, Volume: 71, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; B7-1 Antigen; Cancer Vaccines; Cell Membrane; Lung Neoplasms; Male; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Inbred F344; Survival Analysis; T-Lymphocytes; Transfection

1997
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells.
    Cancer research, 1997, Jun-01, Volume: 57, Issue:11

    Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; Doxorubicin; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methotrexate; Osteosarcoma; Phosphorylation; Quinazolines; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Tetracycline; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured

1997
Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma: analysis of the literature.
    Cancer, 1997, Aug-01, Volume: 80, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Administration Schedule; Humans; Methotrexate; Osteosarcoma

1997
Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity: results in 18 cases and comparison with 112 contemporary osteosarcoma patients treated with the same chemotherapy regimen.
    Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Amputation, Surgical; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Leg; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma

1997
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis.
    Life sciences, 1997, Volume: 61, Issue:19

    Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Humans; Male; Methotrexate; Microdialysis; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Nude; Transplantation, Heterologous; Tumor Cells, Cultured

1997
[The application of intraarterial chemotherapy for the treatment of osteogenic sarcoma in children].
    Klinichna khirurhiia, 1997, Issue:2

    Topics: Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Osteosarcoma

1997
Predictive factors of histologic response to primary chemotherapy in osteosarcoma of the extremity: study of 272 patients preoperatively treated with high-dose methotrexate, doxorubicin, and cisplatin.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma; Retrospective Studies

1998
Neoadjuvant chemotherapy for extremity osteosarcoma--preliminary results of the Rizzoli's 4th study.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Preoperative Care

1998
Augmentation of anti-tumor effects of methotrexate by distilled water on Dunn osteosarcoma in mouse air pouch.
    Cancer letters, 1998, Apr-24, Volume: 126, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Synergism; Male; Methotrexate; Mice; Mice, Inbred C3H; Osteosarcoma; Solutions; Water

1998
Monitoring methotrexate levels in osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:6

    Topics: Chemotherapy, Adjuvant; Humans; Methotrexate; Osteosarcoma; Prognosis; Retrospective Studies

1998
Effect of methotrexate on distraction osteogenesis.
    Clinical orthopaedics and related research, 1998, Issue:354

    Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Neoplasms; Bone Regeneration; Calcification, Physiologic; Calcium; Disease Models, Animal; External Fixators; Female; Humans; Ilizarov Technique; Methotrexate; Osteogenesis, Distraction; Osteosarcoma; Phosphorus; Placebos; Rabbits; Radiography; Random Allocation; Tibia

1998
[Carboxypeptidase-G2 rescue of methotrexate intoxication].
    Bulletin du cancer, 1998, Volume: 85, Issue:12

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Osteosarcoma; Poisoning

1998
Ifosfamide/etoposide alternating with high-dose methotrexate: evaluation of a chemotherapy regimen for poor-risk osteosarcoma.
    British journal of cancer, 1999, Volume: 79, Issue:7-8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Humans; Ifosfamide; Male; Methotrexate; Osteosarcoma; Recurrence; Retrospective Studies

1999
Mechanisms of methotrexate resistance in osteosarcoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Biological Transport; Blotting, Southern; Carrier Proteins; Child; Drug Resistance, Neoplasm; Female; Gene Amplification; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Osteosarcoma; Reduced Folate Carrier Protein; RNA, Messenger; Tetrahydrofolate Dehydrogenase

1999
Accumulation of methotrexate in human tissues following high-dose methotrexate therapy.
    JPMA. The Journal of the Pakistan Medical Association, 1998, Volume: 48, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Gallbladder; Humans; Kidney; Liver; Male; Methotrexate; Muscle, Skeletal; Osteosarcoma; Tissue Distribution

1998
High-dose leucovorin as sole therapy for methotrexate toxicity.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:5

    Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Creatinine; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Kidney; Leucovorin; Methotrexate; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia

1999
Omeprazole does not alter plasma methotrexate clearance.
    Cancer chemotherapy and pharmacology, 1999, Volume: 44, Issue:1

    Topics: Adult; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Kidney; Male; Methotrexate; Omeprazole; Osteosarcoma

1999
Prognostic factors in non-metastatic limb osteosarcoma: A 20-year experience of one center.
    International journal of oncology, 1999, Volume: 15, Issue:1

    Topics: Adolescent; Alkaline Phosphatase; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Cohort Studies; Combined Modality Therapy; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Extremities; Female; Humans; Israel; L-Lactate Dehydrogenase; Leucovorin; Life Tables; Male; Methotrexate; Neoplasm Proteins; Neoplasm Staging; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies; Risk Factors; Salvage Therapy; Survival Analysis; Treatment Outcome; Vincristine

1999
Prognostic value of DNA ploidy response to chemotherapy in human osteosarcomas.
    Cancer letters, 1999, Jul-01, Volume: 141, Issue:1-2

    Topics: Adolescent; Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Humans; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Osteosarcoma; Ploidies; Prognosis

1999
Osteosarcoma of the pelvis.
    The Journal of bone and joint surgery. British volume, 1999, Volume: 81, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Cisplatin; Doxorubicin; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Pelvic Neoplasms; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Survival Rate

1999
Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:9

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy Dosage; Rhabdomyosarcoma; Sarcoma, Ewing

1999
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Cisplatin; Cyclophosphamide; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; Humans; Methotrexate; Oligopeptides; Osteosarcoma; Tumor Cells, Cultured; Vincristine

2000
Successful rescue by oral cholestyramine of a patient with methotrexate nephrotoxicity: nonrenal excretion of serum methotrexate.
    Medical and pediatric oncology, 2000, Volume: 34, Issue:3

    Topics: Anion Exchange Resins; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Cholestyramine Resin; Humans; Kidney; Liver; Male; Methotrexate; Osteosarcoma; Tibia; Time Factors; Treatment Outcome

2000
[Primary chemotherapy with the Rosen T10 protocol before conservative surgery in limb primitive osteosarcomas: results about 56 cases].
    Bulletin du cancer, 2000, Volume: 87, Issue:2

    Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; L-Lactate Dehydrogenase; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Prospective Studies; Survival Analysis; Tomography, X-Ray Computed; Vincristine

2000
Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2000, Volume: 18, Issue:1

    Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Caspases; Cisplatin; Doxorubicin; Enzyme Activation; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Methotrexate; Mitochondria; Osteosarcoma; Tumor Cells, Cultured

2000
[The analysis of failures in therapy of osteosarcoma in children treated according to SFOP-94 protocol in the studies of Polish pediatric solid tumors treatment group].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1998, Volume: 51 Suppl 4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Poland; Retrospective Studies; Survival Rate; Treatment Failure

1998
[Toxicosis of high-dose methotrexate (HD-MTX) for osteosarcoma, cured with treatment by leucovorin (LV) rescue and hemoperfusion--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Arthroplasty, Replacement, Knee; Combined Modality Therapy; Femoral Neoplasms; Hemoperfusion; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Vincristine

2000
Cytotoxic effect of methotrexate and its solvent on osteosarcoma cells in vitro.
    The Journal of bone and joint surgery. British volume, 1999, Volume: 81, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bone Cements; Bone Neoplasms; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Drug Implants; Humans; In Vitro Techniques; Methotrexate; Osteoblasts; Osteosarcoma; Pyrrolidinones; Tumor Cells, Cultured

1999
Anaplastic osteosarcoma with abundant eosinophilic cytoplasm and minimal osteoid production.
    Pathology international, 2000, Volume: 50, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Child; Cisplatin; Cytoplasm; Doxorubicin; Drug Therapy, Combination; Eosine Yellowish-(YS); Fatal Outcome; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methotrexate; Neoplasm Proteins; Osteosarcoma; Staining and Labeling; Tibia; Tomography, X-Ray Computed

2000
Allergic reaction to high-dose methotrexate.
    Medical and pediatric oncology, 2000, Volume: 35, Issue:2

    Topics: Adolescent; Anti-Anxiety Agents; Antimetabolites, Antineoplastic; Antipruritics; Bone Neoplasms; Diphenhydramine; Drug Eruptions; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Immunosuppressive Agents; Male; Methotrexate; Ondansetron; Osteosarcoma; Premedication; Tibia; Urticaria

2000
Potential interaction between methotrexate and omeprazole.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:9

    Topics: Child; Drug Interactions; Enzyme Inhibitors; Folic Acid Antagonists; Half-Life; Humans; Inactivation, Metabolic; Male; Methotrexate; Omeprazole; Osteosarcoma

2000
High-dose methotrexate is lethal to rats. Why give it to children?
    Pediatric hematology and oncology, 2000, Volume: 17, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats

2000
Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: long-term results for patients treated according to the Rizzoli IOR/OS-3b protocol.
    Journal of chemotherapy (Florence, Italy), 2001, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Methotrexate; Neoadjuvant Therapy; Osteosarcoma; Time Factors; Treatment Outcome

2001
Transient posterior encephalopathy induced by chemotherapy in children.
    Pediatric neurology, 2001, Volume: 24, Issue:2

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Cyclophosphamide; Dactinomycin; Female; Humans; Hypertension; Magnesium Deficiency; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Radiopharmaceuticals; Remission Induction; Syndrome; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

2001
Methotrexate poisoning with acute hepatorenal dysfunction.
    Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:1

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Hemofiltration; Humans; Liver Diseases; Methotrexate; Osteosarcoma; Plasma Exchange; Renal Dialysis; Treatment Outcome

2001
Histologic response of high-grade nonmetastatic osteosarcoma of the extremity to chemotherapy,.
    Clinical orthopaedics and related research, 2001, Issue:386

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Extremities; Female; Humans; Ifosfamide; Logistic Models; Male; Methotrexate; Multivariate Analysis; Osteonecrosis; Osteosarcoma; Preoperative Care; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Treatment Outcome

2001
Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases.
    Journal of chemotherapy (Florence, Italy), 2001, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Female; Humans; Ifosfamide; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Multiple Primary; Osteosarcoma; Survival Rate; Treatment Outcome

2001
Long-term local intensive preoperative chemotherapy and joint-preserving conservative surgery for osteosarcoma around the knee.
    Orthopedics, 2001, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Chemotherapy, Cancer, Regional Perfusion; Cisplatin; Disease-Free Survival; Doxorubicin; Female; Femoral Neoplasms; Humans; Hyperthermia, Induced; Infusions, Intravenous; Injections, Intra-Arterial; Knee Joint; Male; Methotrexate; Neoplasm Staging; Osteosarcoma; Osteotomy; Preoperative Care; Tibia; Time Factors; Treatment Outcome

2001
[Methotrexate-ciprofloxacin interaction: report of two cases of severe intoxication].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2001, Volume: 8, Issue:10

    Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Ciprofloxacin; Drug Interactions; Female; Humans; Male; Methotrexate; Neuroblastoma; Osteosarcoma

2001
Adjuvant chemotherapy for osteosarcoma may not increase survival after neoadjuvant chemotherapy and surgical resection.
    Journal of surgical oncology, 2001, Volume: 78, Issue:3

    Topics: Adolescent; Adult; Aged; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Survival Rate

2001
High-dose methotrexate in fibroblastic osteosarcoma.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:12

    Topics: Adult; Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Dose-Response Relationship, Drug; Half-Life; Humans; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma

2001
The cytotoxic effect of methotrexate loaded bone cement on osteosarcoma cell lines.
    International orthopaedics, 2001, Volume: 25, Issue:6

    Topics: Antimetabolites, Antineoplastic; Bone Cements; Bone Neoplasms; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Methotrexate; Osteosarcoma; Tumor Cells, Cultured

2001
[Flow cytometry for testing chemosensitivity of malignant bone tumors].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1999, Volume: 37, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorouracil; Humans; Methotrexate; Mitomycin; Osteosarcoma

1999
Significant impairment of high-dose methotrexate clearance following vancomycin administration in the absence of overt renal impairment.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Vancomycin

2002
[A case of subacute transient cerebral dysfunction in a osteosarcoma patient following high-dose methotrexate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bone Neoplasms; Brain Diseases; Cisplatin; Drug Administration Schedule; Humans; Male; Methotrexate; Osteosarcoma

2002
[An autopsy case of pulmonary and central nervous system metastatic osteosarcoma treated with thirty-six courses of chemotherapy over four years].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2002, Volume: 40, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Carboplatin; Cisplatin; Dacarbazine; Deoxycytidine; Docetaxel; Drug Administration Schedule; Etoposide; Gemcitabine; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Paclitaxel; Spinal Cord Neoplasms; Survivors; Taxoids; Vincristine; Vindesine

2002
Interaction between methotrexate and ciprofloxacin.
    Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:4

    Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Ciprofloxacin; Drug Interactions; Female; Humans; Male; Methotrexate; Neuroblastoma; Osteosarcoma

2002
[Results of treatment of osteosarcoma in children according to the SFOP-94 protocol in the experience of the Polish Paediatric Solid Tumour Study Group].
    Medycyna wieku rozwojowego, 2000, Volume: 4, Issue:1 Suppl 2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Female; Femur; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Poland; Remission Induction; Retrospective Studies; Tibia; Time Factors

2000
Improvement in the results of treatment of osteogenic sarcoma.
    Surgery, gynecology & obstetrics, 1975, Volume: 140, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Amputation, Surgical; Bone Neoplasms; Child; Doxorubicin; Hemipelvectomy; Humans; Leg; Lung Neoplasms; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Palliative Care; Pneumonectomy; Remission, Spontaneous

1975
[Clinical observations on the use of high-dose methotrexate treatment in osteogenic sarcoma (author's transl)].
    Wiener klinische Wochenschrift, 1977, Jul-15, Volume: 89, Issue:14

    Topics: Adolescent; Adult; Bleomycin; Bone Neoplasms; Child; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Osteosarcoma; Vincristine

1977
[Therapy of malignant tumors through the internist].
    Aktuelle Probleme in Chirurgie und Orthopadie, 1977, Volume: 5

    Topics: Bleomycin; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Melphalan; Methotrexate; Osteosarcoma; Plasmacytoma; Prednisone; Sarcoma, Ewing; Vincristine

1977
Malignant bone tumors: spindle-cell sarcomas.
    Pediatric annals, 1978, Volume: 7, Issue:8

    Topics: Adolescent; Amputation, Surgical; Bleomycin; Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Preoperative Care; Prostheses and Implants; Radiography; Vincristine

1978
Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery.
    Cancer, 1979, Volume: 43, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Bleomycin; Bone Neoplasms; Brain; Child; Cyclophosphamide; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Time Factors; Vincristine

1979
Clinical use of high dose methotrexate within the Queensland Radium Institute.
    Clinical and experimental pharmacology & physiology. Supplement, 1979, Volume: 5

    Topics: Australia; Carcinoma, Squamous Cell; Child; Chondrosarcoma; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Palliative Care; Teratoma; Testicular Neoplasms

1979
High-dose methotrexate for the patient with osteogenic sarcoma.
    The American journal of nursing, 1976, Volume: 76, Issue:11

    Topics: Administration, Oral; Adolescent; Amphotericin B; Anorexia; Blood Platelets; Blood Transfusion; Candidiasis; Drug Eruptions; Humans; Infusions, Parenteral; Injections, Intramuscular; Leucovorin; Methotrexate; Nausea; Osteosarcoma; Pneumothorax; Stomatitis; Vomiting

1976
[Cellular immunity during and after high-dose methotrexate therapy in patients with osteosarcoma (author's transl)].
    Wiener klinische Wochenschrift, 1977, Nov-25, Volume: 89, Issue:22

    Topics: Adolescent; Adult; Child; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Methotrexate; Mitogens; Osteosarcoma

1977
From wild fowl to stalking horses: alchemy in chemotherapy. Fifth annual David A. Karnofsky Memorial Lecture.
    Cancer, 1975, Volume: 35, Issue:4

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Brain Neoplasms; Drug Therapy, Combination; History, 20th Century; Hodgkin Disease; Humans; Infections; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Wilms Tumor

1975
Childhood cancer: the improving prognosis.
    Postgraduate medicine, 1976, Volume: 59, Issue:2

    Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Rhabdomyosarcoma; Teniposide; Thioguanine; Vincristine; Wilms Tumor

1976
Osteogenic sarcoma in a patient with aplastic anemia.
    Southern medical journal, 1977, Volume: 70, Issue:7

    Topics: Adolescent; Anemia, Aplastic; Bone Neoplasms; Chloramphenicol; Humans; Male; Methotrexate; Osteosarcoma; Prednisone; Testosterone

1977
[Serum methotrexate determination by microbiological assay in patients receiving high-dosage methotrexate (author's transl)].
    Wiener klinische Wochenschrift, 1977, Jul-15, Volume: 89, Issue:14

    Topics: Bone Neoplasms; Humans; Methotrexate; Osteosarcoma; Radioimmunoassay

1977
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; Metronidazole; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Sarcoma, Ewing

1977
Anaphylactoid type reactions in two patients receiving high dose intravenous methotrexate.
    Cancer, 1978, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Anaphylaxis; BCG Vaccine; Bone Neoplasms; Drug Contamination; Humans; Injections, Intravenous; Male; Methotrexate; Osteosarcoma

1978
Sarcoidosis following adjuvant high-dose methotrexate therapy for osteosarcoma.
    Archives of internal medicine, 1978, Volume: 138, Issue:3

    Topics: Adolescent; Amputation, Surgical; Femoral Neoplasms; Humans; Male; Methotrexate; Osteosarcoma; Radiography; Sarcoidosis

1978
Pulmonary resection in children with metastatic osteogenic sarcoma: improved survival with surgery, chemotherapy, and irradiation.
    The Journal of thoracic and cardiovascular surgery, 1978, Volume: 75, Issue:3

    Topics: Adolescent; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonectomy; Prognosis; Radiography; Vincristine

1978
Proceedings of the Osteosarcoma Study Group Meeting (Bethesda, Maryland, January 19, 1977): introduction: treatment of osteogenic sarcoma.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Humans; Methotrexate; Osteosarcoma

1978
[Malignant juvenile bone tumors].
    Medizinische Klinik, 1978, Jun-02, Volume: 73, Issue:22

    Topics: Adolescent; Adult; Aged; Amputation, Surgical; Bone Neoplasms; Child; Diagnosis, Differential; Doxorubicin; Drug Therapy, Combination; Eosinophilic Granuloma; Female; Folic Acid; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteomyelitis; Osteosarcoma; Sarcoma, Ewing

1978
[Bone and soft tissue sarcomas].
    Schweizerische medizinische Wochenschrift, 1978, Sep-02, Volume: 108, Issue:35

    Topics: Aged; Child; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Therapy, Combination; Female; Humans; Life Expectancy; Methotrexate; Osteosarcoma; Prednisone; Remission, Spontaneous; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine

1978
Osteogenic sarcoma complicating osteogenesis imperfecta tarda.
    European journal of pediatrics, 1978, Oct-12, Volume: 129, Issue:3

    Topics: Adolescent; Amputation, Surgical; Femoral Neoplasms; Humans; Male; Methotrexate; Osteogenesis Imperfecta; Osteosarcoma

1978
[First experiences after exclusive radiotherapy of primary bone tumors (proceedings)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Adolescent; Adult; Bone Neoplasms; Chondrosarcoma; Cobalt Radioisotopes; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1978
[First results of adjuvant chemotherapy in osteosarcoma (proceedings)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Doxorubicin; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
[5 year study on 88 osteosarcoma patients with combined surgical and adriamycin treatment (proceedings)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Osteosarcoma; Prognosis

1978
Characterization of methotrexate recovered from the urine of high dose patients for the purpose of clinical re-use.
    European journal of cancer, 1978, Volume: 14, Issue:10

    Topics: Adolescent; Adult; Animals; Chromatography, Ion Exchange; Female; Humans; Leukemia, Experimental; Male; Methotrexate; Mice; Osteosarcoma; Pyrogens; Spectrophotometry, Ultraviolet

1978
[Osteosarcoma 1978 a turning point in prognosis through adjuvant chemotherapy following adequate surgery (author's transl)].
    Wiener klinische Wochenschrift. Supplementum, 1978, Volume: 93

    Topics: Adolescent; Amputation, Surgical; Bone Neoplasms; Child; Cyclophosphamide; Female; Femur; Humans; Humerus; Male; Melphalan; Methotrexate; Mitomycins; Osteosarcoma; Prognosis; Prostheses and Implants; Tibia

1978
Current trends and prospects in surgical adjuvant trials.
    Archiv fur Geschwulstforschung, 1978, Volume: 48, Issue:7

    Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Dianhydrogalactitol; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Rectal Neoplasms

1978
Age-related pharmacokinetics of high-dose methotrexate in patients with osteosarcoma.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Kinetics; Methotrexate; Middle Aged; Osteosarcoma

1979
[Radioimmunoassay of methotrexate during treatment using high doses].
    La Nouvelle presse medicale, 1979, Feb-10, Volume: 8, Issue:7

    Topics: Adolescent; Adult; Breast Neoplasms; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Radioimmunoassay; Time Factors

1979
Adjuvant therapy in the management of osteosarcoma: need for critical reassessment.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1978, Volume: 68

    Topics: Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1978
[Multidrug chemotherapy of osteogenic sarcoma (author's transl)].
    Blut, 1979, Volume: 39, Issue:4

    Topics: Doxorubicin; Humans; Methotrexate; Osteosarcoma; Postoperative Care

1979
Vincristine-methotrexate combination chemotherapy and the influence of weight loss on experimental tumour growth.
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:2

    Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Starvation; Vincristine

1979
[The use and side effects of chemotherapy in the treatment of malignant bone tumors (osteosarcoma and Ewing's sarcoma) (author's transl)].
    Unfallheilkunde, 1979, Volume: 82, Issue:12

    Topics: Adolescent; Adult; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1979
Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.
    Archives of pathology & laboratory medicine, 1977, Volume: 101, Issue:1

    Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Necrosis; Osteocytes; Osteosarcoma; Tibia; Vincristine

1977
Weekly high-dose methotrexate-citrovorum factor in osteogenic sarcoma: pre-surgical treatment of primary tumor and of overt pulmonary metastases.
    Cancer, 1977, Volume: 39, Issue:1

    Topics: Bone Neoplasms; Drug Administration Schedule; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission, Spontaneous; Vincristine

1977
Adjuvant multiple drug chemotherapy for osteosarcoma of the extremity.
    Cancer, 1977, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Agents; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1977
Total femur replacement.
    Comprehensive therapy, 1977, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Chondrosarcoma; Cyclophosphamide; Doxorubicin; Female; Femoral Neoplasms; Femur; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Postoperative Complications; Prostheses and Implants; Vincristine

1977
Multidisciplinary treatment for childhood sarcoma.
    American journal of surgery, 1977, Volume: 133, Issue:4

    Topics: Adolescent; Age Factors; Antineoplastic Agents; Bone Neoplasms; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Leucovorin; Lymphatic Metastasis; Male; Methods; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine

1977
Osteosarcoma during pregnancy.
    Obstetrics and gynecology, 1977, Volume: 50, Issue:1 Suppl

    Topics: Abortion, Induced; Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Extremities; Female; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pregnancy; Pregnancy Complications; Vincristine

1977
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
    Seminars in oncology, 1977, Volume: 4, Issue:2

    Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine

1977
High-dose methotrexate with citrovorum factor in osteogenic sarcoma--progress report II.
    Cancer treatment reports, 1977, Volume: 61, Issue:4

    Topics: Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1977
Current concepts in the management of disseminated malignant bone disease in childhood.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma; Sarcoma, Ewing; Vincristine

1977
Surgical management of malignant bone tumours.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Adult; Amputation, Surgical; Bone Neoplasms; Child; Chondrosarcoma; Fibrosarcoma; Humans; Leucovorin; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1977
Effect of hydration on plasma-methotrexate levels.
    Cancer treatment reports, 1977, Volume: 61, Issue:7

    Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Sodium; Solutions; Water

1977
[Chemotherapy of osteosarcoma (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1977, Dec-16, Volume: 102, Issue:50

    Topics: Adolescent; Age Factors; Bone Neoplasms; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methods; Methotrexate; Osteosarcoma; Time Factors

1977
Pathologic aspects of chemotherapy response in the treatment of osteogenic sarcoma. An analysis of two cases.
    Oncology, 1977, Volume: 34, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Tibia

1977
Limb preservation in osteogenic sarcoma: a preliminary report.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1977, Issue:62

    Topics: Adolescent; Antineoplastic Agents; Doxorubicin; Femur; Humans; Humerus; Injections, Intra-Arterial; Leucovorin; Methotrexate; Osteosarcoma; Prostheses and Implants; Tibia; Vincristine

1977
High-dose methotrexate, not a conventional treatment.
    Cancer treatment reports, 1978, Volume: 62, Issue:1

    Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Research Design

1978
Adjuvant chemotherapy of osteogenic sarcoma: progress and perspectives.
    Journal of the National Cancer Institute, 1978, Volume: 60, Issue:1

    Topics: Antineoplastic Agents; Cell Count; Cell Survival; Child; Drug Resistance; Drug Therapy, Combination; Female; Humans; Kinetics; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
Patient case involving high-dose methotrexate followed by leucovorin rescue.
    American journal of hospital pharmacy, 1978, Volume: 35, Issue:2

    Topics: Adolescent; Drug Therapy, Combination; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1978
Chemotherapy and thoractomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the timing of thoracic surgery.
    Cancer, 1978, Volume: 41, Issue:3

    Topics: Child; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
"Single"-agent activity of high-dose methotrexate with citrovorum factor rescue.
    Cancer treatment reports, 1978, Volume: 62, Issue:2

    Topics: Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Osteosarcoma; Vincristine

1978
[High-dose methotrexate/leucovorin adjuvant chemotherapy of osteogenic sarcoma: biochemical effects in DNA-synthesis of bone marrow cells (author's transl)].
    Blut, 1978, Jun-20, Volume: 36, Issue:6

    Topics: Bone Marrow; Bone Neoplasms; DNA; Humans; Leucovorin; Methotrexate; Osteosarcoma

1978
Serum copper and zinc measurement in patients with osteogenic sarcoma.
    Cancer, 1978, Volume: 42, Issue:2

    Topics: Adolescent; Adult; BCG Vaccine; Copper; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Recurrence; Spectrometry, X-Ray Emission; Time Factors; Zinc

1978
Degradation and clearance of methotrexate in children with osteosarcoma receiving high-dose infusion.
    Medical and pediatric oncology, 1978, Volume: 4, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Half-Life; Humans; Injections, Intravenous; Leucovorin; Methotrexate; Osteosarcoma; Time Factors

1978
Osteosarcoma--the winds of change.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1978, May-06, Volume: 53, Issue:18

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1978
[Chemotherapy of osteo and Ewing sarcomas].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Remission, Spontaneous; Sarcoma, Ewing; Vincristine

1978
[Experiences with high dose methotrexate treatments within the framework of polychemotherapy in osteosarcoma (proceedings)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1978, Volume: 116, Issue:4

    Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
Transient cerebral dysfunction following chemotherapy for osteogenic sarcoma.
    Annals of neurology, 1978, Volume: 3, Issue:5

    Topics: Adolescent; Adult; Bone Neoplasms; Brain Diseases; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Humerus; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pelvic Bones; Syndrome; Vincristine

1978
High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma.
    American journal of veterinary research, 1978, Volume: 39, Issue:12

    Topics: Animals; Bone Neoplasms; Dog Diseases; Dogs; Female; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1978
High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer.
    Cancer, 1979, Volume: 43, Issue:4

    Topics: Adolescent; Adult; Aged; Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma

1979
[High-dose methotrexate therapy in osteogenic sarcoma: plasma pharmakokinetics to predict toxicity (author's transl)].
    Klinische Wochenschrift, 1979, Apr-17, Volume: 57, Issue:8

    Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Creatinine; Humans; Leucovorin; Methotrexate; Osteosarcoma; Radioimmunoassay; Stomatitis

1979
[Course of metastatic osteogenic sarcoma treated with chemotherapy only (author's transl)].
    Archives of orthopaedic and traumatic surgery. Archiv fur orthopadische und Unfall-Chirurgie, 1979, Apr-30, Volume: 93, Issue:4

    Topics: Antineoplastic Agents; Child; Doxorubicin; Drug Therapy, Combination; Female; Femoral Neoplasms; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiography; Remission, Spontaneous; Sacrum; Vincristine

1979
Evaluation of overall toxicity of high-dosage methotrexate regimens.
    Medical and pediatric oncology, 1979, Volume: 6, Issue:3

    Topics: Adolescent; Age Factors; Bone Marrow; Bone Neoplasms; Child; Dermatitis; Drug Administration Schedule; Female; Humans; Kidney; Leucovorin; Leukopenia; Liver; Male; Methotrexate; Osteosarcoma; Sex Factors; Stomatitis; Thrombocytopenia; Vincristine

1979
Serum levels of methotrexate by the ligand-binding assay after "high-dose" therapy for osteosarcoma.
    Cancer, 1979, Volume: 44, Issue:3

    Topics: Drug Therapy, Combination; Humans; Leucovorin; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Tetrahydrofolate Dehydrogenase

1979
Effect of high-dose methotrexate with citrovorum factor on human granulopoiesis.
    Cancer research, 1979, Volume: 39, Issue:10

    Topics: Bone Marrow; Colony-Forming Units Assay; Drug Therapy, Combination; Granulocytes; Hematopoiesis; Humans; Leucovorin; Methotrexate; Osteosarcoma

1979
Significance of the 48-hour plasma level in high-dose methotrexate regimens.
    Cancer clinical trials, 1978,Summer, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Age Factors; Bone Marrow; Child; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Liver; Methotrexate; Osteosarcoma; Time Factors

1978
The biochemistry of the citrovorum factor rescue effect in normal bone marrow cells after high-dose methotrexate.
    European journal of cancer, 1979, Volume: 15, Issue:10

    Topics: Adult; Bone Marrow; Cells, Cultured; Deoxyuridine; Humans; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Osteosarcoma; Thymidine; Thymidine Kinase

1979
Pharmacokinetic monitoring of high-dose methotrexate. Early recognition of high-risk patients.
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:3

    Topics: Bone Neoplasms; Drug Therapy, Combination; Half-Life; Humans; Kinetics; Leucovorin; Methotrexate; Osteosarcoma; Risk; Time Factors

1979
Treatment of osteosarcoma.
    Clinical and experimental pharmacology & physiology. Supplement, 1979, Volume: 5

    Topics: Adolescent; Antineoplastic Agents; Child; Female; Humans; Male; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1979
Radiation in bone sarcomas: a re-evaluation in the era of intensive systemic chemotherapy.
    Cancer, 1977, Volume: 39, Issue:2 Suppl

    Topics: Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiation Tolerance; Radiotherapy Dosage; Radiotherapy, High-Energy; Sarcoma, Ewing; Vincristine

1977
Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma.
    Cancer, 1977, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Prognosis; Radiotherapy, High-Energy

1977
Management of osteogenic sarcoma at the Mayo Clinic.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1976, Issue:54

    Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Child, Preschool; Doxorubicin; Drug Therapy, Combination; Female; Humans; Immunotherapy; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Radiotherapy, High-Energy; Transfer Factor; Vincristine

1976
Editorial: New therapies for osteogenic sarcoma.
    The Journal of bone and joint surgery. American volume, 1975, Volume: 57, Issue:2

    Topics: Amputation, Surgical; Bone Neoplasms; Doxorubicin; Humans; Immunotherapy; Lymphocytes; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1975
[Association of radical surgery and cyclic polychemotherapy (with vincristine, methotrexate and adriamycin) in the treatment of some forms of osteosarcoma. Preliminary results].
    La Chirurgia degli organi di movimento, 1975, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Postoperative Care; Vincristine

1975
Assay of cell-mediated cytotoxicity by tritiated thymidine labeled tumor cells.
    Journal of immunological methods, 1975, Volume: 7, Issue:4

    Topics: Autoradiography; Cytotoxicity Tests, Immunologic; Fibroblasts; Humans; Immunity, Cellular; Isotope Labeling; Lymphocytes; Methotrexate; Osteosarcoma; Thymidine; Tritium

1975
Chemotherapy of osteosarcoma.
    Clinical orthopaedics and related research, 1975, Issue:111

    Topics: Amputation, Surgical; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Lung Neoplasms; Melphalan; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1975
A case of osteogenic sarcoma of maxillary antrum cure by radiation therapy.
    Journal de radiologie, d'electrologie, et de medecine nucleaire, 1975, Volume: 56, Issue:5

    Topics: Adolescent; Female; Humans; Maxillary Sinus; Methotrexate; Osteosarcoma; Paranasal Sinus Neoplasms; Radiotherapy Dosage; Time Factors

1975
Investigation of carbohydrate metabolism and somatomedin in osteosarcoma patients.
    Journal of surgical oncology, 1975, Volume: 7, Issue:5

    Topics: Adolescent; Bone Development; Carbohydrate Metabolism; Cartilage; Cells, Cultured; Estradiol; Female; Growth Hormone; Humans; Male; Methotrexate; Osteosarcoma; Sex Factors; Somatomedins

1975
Toxicity of doxorubicin and methotrexate in osteogenic sarcoma.
    British medical journal, 1976, Jan-03, Volume: 1, Issue:6000

    Topics: Adolescent; Doxorubicin; Drug Therapy, Combination; Female; Humans; Methotrexate; Osteosarcoma; Time Factors; Vincristine

1976
[Supplementary antiblastic polychemotherapy in localized malignant bone tumors. I. Ewing's sarcoma and osteosarcoma].
    La Chirurgia degli organi di movimento, 1975, Volume: 62, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Sarcoma, Ewing; Vincristine

1975
7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.
    The Journal of clinical investigation, 1976, Volume: 57, Issue:2

    Topics: Adult; Animals; Bone Neoplasms; Carcinoma, Squamous Cell; Child; Female; Histocytochemistry; Humans; Kidney; Lung Neoplasms; Macaca mulatta; Male; Methotrexate; Middle Aged; Osteosarcoma; Time Factors

1976
The results of surgical treatment combined with intra-arterial infusion of anti-cancer agents in osteosarcoma.
    Clinical orthopaedics and related research, 1976, Issue:120

    Topics: Adolescent; Adult; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Extremities; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Male; Methotrexate; Mitomycins; Osteosarcoma

1976
Effects of methotrexate on deoxyribonucleotide pools and nucleic acid synthesis in human osteosarcoma cells.
    European journal of cancer, 1976, Volume: 12, Issue:10

    Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Breast Neoplasms; Cells, Cultured; Deoxyribonucleotides; Deoxyuridine; DNA; Female; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; RNA; Time Factors

1976
Immunotherapy of osteosarcoma patients with virus-modified tumor cells.
    Annals of the New York Academy of Sciences, 1976, Volume: 277, Issue:00

    Topics: Adolescent; Adult; Antibodies, Neoplasm; Antibodies, Viral; Antibody Formation; Bone Neoplasms; Cell Line; Child; Female; Humans; Immunity, Cellular; Immunization; Immunotherapy; Kinetics; Male; Methotrexate; Orthomyxoviridae; Osteosarcoma; Vaccines

1976
Primary malignant tumours of bone.
    British medical journal, 1976, Dec-04, Volume: 2, Issue:6048

    Topics: Adolescent; Amputation, Surgical; Animals; Bone Neoplasms; Child; Chondrosarcoma; Dogs; Doxorubicin; Fibrosarcoma; Giant Cell Tumors; Humans; Methotrexate; Middle Aged; Osteosarcoma; Vincristine

1976
Adjuvant chemotherapy associated with surgery in the treatment of osteosarcoma. Preliminary results.
    Italian journal of orthopaedics and traumatology, 1976, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Depression, Chemical; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Immunity; Male; Methotrexate; Middle Aged; Osteosarcoma; Vincristine

1976
Letter: Limitations of methotrexate and citrovorum-factor treatment.
    The New England journal of medicine, 1975, 01-09, Volume: 292, Issue:2

    Topics: Adult; Antineoplastic Agents; Child; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma

1975
Letter: Management of osteogenic sarcoma.
    The New England journal of medicine, 1975, Feb-20, Volume: 292, Issue:8

    Topics: Adult; Doxorubicin; Humans; Leucovorin; Methotrexate; Osteosarcoma

1975
The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy.
    Cancer, 1975, Volume: 35, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1975
Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma.
    Cancer, 1975, Volume: 35, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pneumonia; Pulmonary Fibrosis; Spinal Cord Compression

1975
The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma.
    Cancer, 1975, Volume: 35, Issue:3 suppl

    Topics: Adolescent; Bone Neoplasms; Child; Cyclophosphamide; Digestive System; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Leucovorin; Male; Methotrexate; Mouth Mucosa; Mucous Membrane; Neoplasm Metastasis; Osteosarcoma; Vincristine

1975
New approaches to cancer chemotherapy with methotrexate.
    The New England journal of medicine, 1975, Apr-17, Volume: 292, Issue:16

    Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides

1975
Letter: Osteosarcoma--new hope.
    British medical journal, 1975, Mar-22, Volume: 1, Issue:5959

    Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1975
Letter: Methotrexate-citrovorum factor in treating osteogenic sarcoma.
    The New England journal of medicine, 1975, May-22, Volume: 292, Issue:21

    Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma

1975
Femur replacement.
    The American journal of nursing, 1975, Volume: 75, Issue:8

    Topics: Adolescent; Adult; Drug Therapy, Combination; Femoral Neoplasms; Femur; Humans; Joint Prosthesis; Leucovorin; Male; Methotrexate; Osteosarcoma

1975
The treatment of pulmonary metastasis in osteogenic sarcoma.
    Clinical orthopaedics and related research, 1975, Issue:111

    Topics: Bone Neoplasms; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1975
Combined radiosensitizer infusion and irradiation of osteogenic sarcomas.
    Radiology, 1975, Volume: 117, Issue:1

    Topics: Bromodeoxyuridine; Child; Female; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Osteosarcoma; Radiation Dosage; Radiation-Sensitizing Agents

1975
Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma.
    Cancer, 1976, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Femur; Hip Joint; Humans; Joint Prosthesis; Knee Joint; Leucovorin; Male; Methotrexate; Osteosarcoma; Prostheses and Implants; Tibia; Vincristine

1976
Failure of leucovorin rescue to prevent reactivation of a solar burn after high dose methotrexate.
    Cancer, 1976, Volume: 37, Issue:4

    Topics: Adult; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Skin; Sunburn

1976
Multidrug chemotherapy in pulmonary treatment of osteosarcoma.
    The Journal of bone and joint surgery. American volume, 1976, Volume: 58, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Melphalan; Methotrexate; Middle Aged; Osteosarcoma; Vincristine

1976
Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.
    The Medical journal of Australia, 1976, May-22, Volume: 1, Issue:21

    Topics: Adolescent; Adult; Child; Female; Humans; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Osteosarcoma

1976
Osteogenic sarcoma: state of the art with high-dose methotrexate treatment.
    Clinical orthopaedics and related research, 1976, Issue:120

    Topics: Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Osteosarcoma; Prognosis; Vincristine

1976
Chemotherapy of osteosarcoma [proceedings].
    Proceedings of the Royal Society of Medicine, 1976, Volume: 69, Issue:8

    Topics: Bone Neoplasms; Child; Dacarbazine; Doxorubicin; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Vincristine

1976
Multidisciplinary treatment for macrometastatic osteogenic sarcoma.
    British medical journal, 1976, Oct-30, Volume: 2, Issue:6043

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Leucovorin; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Vincristine

1976
Plasma amino acids during high-dose methotrexate-citrovorum "rescue".
    Biochemical medicine, 1976, Volume: 16, Issue:1

    Topics: Adult; Amino Acids; Cysteine; Humans; Kinetics; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine

1976
Encapsulation around malignant bone tumors after preoperative adjuvant treatment.
    Nihon Seikeigeka Gakkai zasshi, 1992, Volume: 66, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Histiocytoma, Benign Fibrous; Humans; Injections, Intravenous; Methotrexate; Middle Aged; Osteosarcoma; Preoperative Care; Vincristine

1992
Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Proportional Hazards Models; Risk Factors; Survival Analysis

1992
Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging.
    Radiology, 1992, Volume: 185, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Contrast Media; Doxorubicin; Drug Combinations; Female; Gadolinium; Gadolinium DTPA; Heterocyclic Compounds; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Meglumine; Methotrexate; Organometallic Compounds; Osteosarcoma; Pentetic Acid; Remission Induction; Subtraction Technique

1992
Missing neutral DNase activity in lymphocytes and phytohemagglutinin-stimulated lymphocytes after high dose methotrexate therapy.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:7

    Topics: Adolescent; Bone Neoplasms; Child; Deoxyribonucleases; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Female; Humans; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Osteosarcoma

1992
Appearance of a methotrexate binding plasma protein during high dose methotrexate therapy.
    JPMA. The Journal of the Pakistan Medical Association, 1992, Volume: 42, Issue:8

    Topics: Adult; Blood Proteins; Dose-Response Relationship, Drug; Femoral Neoplasms; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Osteosarcoma; Protein Binding

1992
[Bone tumors in children. Current trends in therapy].
    Pathologie-biologie, 1992, Volume: 39, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Infant; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1992
[Osteogenic sarcoma of the limbs: value of intra-arterial chemotherapy before surgery. Preliminary results].
    Pathologie-biologie, 1992, Volume: 39, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Infusions, Intra-Arterial; Methotrexate; Osteosarcoma; Preoperative Care; Vincristine

1992
Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Antiemetics; Antineoplastic Agents; Bone Neoplasms; Cyclophosphamide; Female; Humans; Ifosfamide; Infusions, Intravenous; Injections, Intravenous; Male; Methotrexate; Nausea; Osteosarcoma; Propofol; Vomiting

1992
Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping.
    Investigative radiology, 1992, Volume: 27, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Contrast Media; Doxorubicin; Female; Gadolinium; Gadolinium DTPA; Humans; Ifosfamide; Magnetic Resonance Imaging; Male; Methotrexate; Necrosis; Organometallic Compounds; Osteosarcoma; Pentetic Acid; Preoperative Care

1992
Monoclonal antibody targeting of methotrexate (MTX) against MTX-resistant tumour cell lines.
    British journal of cancer, 1992, Volume: 65, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Binding, Competitive; Biological Transport; Drug Resistance; Humans; Immunotoxins; In Vitro Techniques; Methotrexate; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1992
Ten years' experience in patients with osteogenic sarcoma in Finland.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1990, Volume: 16, Issue:2

    Topics: Actuarial Analysis; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Finland; Humans; Male; Methotrexate; Osteosarcoma; Survival Rate

1990
Accumulation, intracellular metabolism, and antitumor activity of high- and low-dose methotrexate in human osteosarcoma xenografts.
    Cancer communications, 1990, Volume: 2, Issue:6

    Topics: Animals; Body Fluids; Carbon Radioisotopes; DNA; Dose-Response Relationship, Drug; Formates; Humans; Intracellular Fluid; Liver; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Polyglutamic Acid; Transplantation, Heterologous; Tritium

1990
Unusually long survival time after resection and irradiation of a brain metastasis from osteosarcoma.
    Neurosurgical review, 1990, Volume: 13, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Femoral Neoplasms; Humans; Interferon Type I; Male; Methotrexate; Osteosarcoma; Prognosis

1990
Preoperative intra-arterial chemotherapy in patients with osteosarcoma: case report of seven patients below the age of 18 years.
    Journal of chemotherapy (Florence, Italy), 1990, Volume: 2, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Doxorubicin; Drug Administration Schedule; Femoral Neoplasms; Humans; Injections, Intra-Arterial; Methotrexate; Osteosarcoma; Tibia

1990
Disposition of high-dose methotrexate in an obese cancer patient.
    Cancer, 1991, Sep-15, Volume: 68, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Half-Life; Humans; Leucovorin; Methotrexate; Obesity; Osteosarcoma; Tibia; Vincristine

1991
Stage IIB osteogenic sarcoma.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Clinical Protocols; Cohort Studies; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; New York City; Osteosarcoma; Osteotomy; Postoperative Care; Predictive Value of Tests; Preoperative Care; Survival Analysis; Survival Rate

1991
Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leg; Male; Methotrexate; Osteosarcoma; Survival Analysis

1991
Secondary acute non-lymphoblastic leukemia in two children following treatment with a cis-diamminedichloroplatinum-II-based regimen for osteosarcoma.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:1

    Topics: Adolescent; Child; Cisplatin; Female; Humans; Leucovorin; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Neoplasms, Second Primary; Osteosarcoma; Vincristine

1992
Can primary osteosarcoma act as a third space after high-dose methotrexate?
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:8

    Topics: Adult; Bone Neoplasms; Half-Life; Humans; Male; Methotrexate; Osteosarcoma

1991
[Severe methotrexate poisoning].
    Presse medicale (Paris, France : 1983), 1991, Nov-02, Volume: 20, Issue:35

    Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Enteritis; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Poisoning; Pulmonary Fibrosis

1991
2,4-diamino-7-hydroxy-pteridines, a new class of catabolites of methotrexate.
    European journal of biochemistry, 1991, Aug-15, Volume: 200, Issue:1

    Topics: Adolescent; Adult; Animals; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hodgkin Disease; Humans; Liver; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Rabbits; Rats

1991
IIB osteosarcoma. Current management, local control, and survival statistics--the Australian experience.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Australia; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Injections, Intra-Arterial; Life Tables; Male; Methotrexate; Middle Aged; Necrosis; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Complications; Radiotherapy; Remission Induction; Survival Rate

1991
Recent advances in the chemotherapy of metastatic osteogenic sarcoma. 1972.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Bone Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; History, 20th Century; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Osteosarcoma

1991
The management of IIB osteosarcoma. Experience from 1976 to 1985.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Amputation, Surgical; Austria; Bone Neoplasms; Bone Transplantation; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Complications; Prostheses and Implants; Surgical Flaps; Survival Analysis; Survival Rate

1991
IIB osteosarcoma. Current management, local control, and survival statistics--São Paulo, Brazil.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brazil; Cisplatin; Combined Modality Therapy; Doxorubicin; Follow-Up Studies; Humans; Ifosfamide; Methotrexate; Neoplasm Staging; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prognosis; Prostheses and Implants; Survival Analysis; Survival Rate

1991
Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities.
    Clinical orthopaedics and related research, 1991, Issue:270

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Lengthening; Bone Neoplasms; Bone Transplantation; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Italy; Male; Methotrexate; Osteosarcoma; Osteotomy; Postoperative Care; Preoperative Care; Prognosis; Prostheses and Implants; Survival Rate

1991
Zürich experience with preoperative, high dose methotrexate-containing chemotherapy in patients with extremity osteosarcomas (OSA).
    Annals of oncology : official journal of the European Society for Medical Oncology, 1991, Volume: 2, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Necrosis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Retrospective Studies; Survival Rate

1991
Efficacy and selectivity of monoclonal-antibody-targeted drugs and free methotrexate in fluorescence-labelled mixed tumour-cell monolayer cultures and multicellular spheroids.
    International journal of cancer, 1991, Oct-21, Volume: 49, Issue:4

    Topics: Antibodies, Monoclonal; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Immunotoxins; Methotrexate; Osteosarcoma; Ovarian Neoplasms; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1991
Increasing alkaline DNase activity with substrate specificity for denaturated DNA after high dose methotrexate therapy.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:6

    Topics: Bone Marrow; Bone Marrow Cells; Child; Deoxyribonucleases; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Isoelectric Focusing; Lymphocytes; Magnesium; Methotrexate; Nucleic Acid Hybridization; Osteosarcoma; Phytohemagglutinins; Substrate Specificity; Thymidine

1991
Cell proliferation rate and tumor volume in human osteosarcoma during exposure to methotrexate. A study on tissue transplants in nude mice.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1991, Volume: 99, Issue:10

    Topics: Adolescent; Animals; Autoradiography; Cell Division; Humans; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Osteosarcoma

1991
Influence of chemotherapy administration on monocyte activation by liposomal muramyl tripeptide phosphatidylethanolamine in children with osteosarcoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:2

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Cyclophosphamide; Doxorubicin; Humans; Liposomes; Lung Neoplasms; Macrophage Activation; Methotrexate; Monocytes; Osteosarcoma; Phosphatidylethanolamines; Tumor Cells, Cultured

1991
Osteogenic sarcoma: MR signal abnormalities of the brain in asymptomatic patients treated with high-dose methotrexate.
    Radiology, 1991, Volume: 179, Issue:2

    Topics: Brain; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Testicular Neoplasms

1991
Acetazolamide for alkalinisation of urine in patients receiving high-dose methotrexate.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:2

    Topics: Acetazolamide; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Kidney; Methotrexate; Osteosarcoma

1991
Combined treatment of osteosarcoma of the limbs at an advanced stage, including hyperthermic-antiblastic perfusion.
    Italian journal of orthopaedics and traumatology, 1990, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Female; Humans; Infusions, Intra-Arterial; Leg; Male; Methotrexate; Osteosarcoma; Radiography

1990
Mega doses of methotrexate in the treatment of osteosarcoma.
    JPMA. The Journal of the Pakistan Medical Association, 1990, Volume: 40, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Remission Induction

1990
[Intra-arterial neoadjuvant chemotherapy of sarcoma of the extremities].
    La Radiologia medica, 1990, Volume: 80, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Follow-Up Studies; Histiocytoma, Benign Fibrous; Humans; Infusions, Intra-Arterial; Methotrexate; Middle Aged; Muscular Diseases; Osteosarcoma; Radiography

1990
Acute onset deafness in a 4-year-old girl after a single infusion of cis-platinum.
    Pediatric hematology and oncology, 1990, Volume: 7, Issue:2

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Femoral Neoplasms; Hearing Loss, Bilateral; Hearing Loss, Sensorineural; Humans; Ifosfamide; Methotrexate; Osteosarcoma

1990
Neoadjuvant chemotherapy for osteosarcoma of the extremities: the Rizzoli Institute experience.
    La Chirurgia degli organi di movimento, 1990, Volume: 75, Issue:1 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care

1990
[The influence of liver and renal functions on the changes in serum methotrexate (MTX) level in high-dose MTX therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:12

    Topics: Adolescent; Adult; Aspartate Aminotransferases; Bone Neoplasms; Child; Child, Preschool; Creatinine; Female; Humans; Kidney; Leucovorin; Liver; Male; Methotrexate; Multivariate Analysis; Osteosarcoma; Regression Analysis

1990
[Adjuvant chemotherapy of osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Humans; Male; Methotrexate; Osteosarcoma; Prognosis; Survival Rate

1990
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli Experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial ci
    Cancer, 1990, Jun-01, Volume: 65, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Survival Rate

1990
The importance of dose-intensity in neoadjuvant chemotherapy of osteosarcoma: a retrospective analysis of high-dose methotrexate, cisplatinum and adriamycin used preoperatively.
    Journal of chemotherapy (Florence, Italy), 1990, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arm; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Protocols; Colorectal Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Humans; Leg; Male; Methotrexate; Osteosarcoma; Preoperative Care; Retrospective Studies

1990
Massive pulmonary tumor emboli in osteosarcoma. Occult and fatal complication.
    Cancer, 1990, Aug-01, Volume: 66, Issue:3

    Topics: Adolescent; Doxorubicin; Female; Femoral Neoplasms; Humans; Lung Neoplasms; Methotrexate; Osteosarcoma; Pulmonary Embolism

1990
Do visual evoked potentials detect neural damage in children treated for cancer?
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy

1990
[The results of using high-dose methotrexate in treating osteogenic sarcoma].
    Voprosy onkologii, 1990, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Drug Evaluation; Female; Femoral Neoplasms; Humans; Humerus; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Preoperative Care; Tibia

1990
Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.
    The American journal of pediatric hematology/oncology, 1990,Summer, Volume: 12, Issue:2

    Topics: Adolescent; Combined Modality Therapy; Encephalocele; Eye Neoplasms; Female; Humans; Infusions, Intravenous; Intracranial Pressure; Methotrexate; Necrosis; Neoplasms, Multiple Primary; Neoplasms, Radiation-Induced; Orbital Neoplasms; Osteosarcoma; Retinoblastoma

1990
[Successful treatment of several metachronous pulmonary metastases of a chondroblastic osteosarcoma].
    Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1985, Volume: 40, Issue:4

    Topics: Amputation, Surgical; Bleomycin; Child; Chondroblastoma; Cyclophosphamide; Dactinomycin; Female; Humans; Ifosfamide; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma; Tibia

1985
The angiographic response of osteosarcoma following pre-operative chemotherapy.
    Skeletal radiology, 1986, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Angiography; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Preoperative Care; Vincristine

1986
Telangiectatic osteogenic sarcoma. Improved survival with combination chemotherapy.
    Clinical orthopaedics and related research, 1986, Issue:207

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1986
Neoadjuvant chemotherapy for osteogenic sarcoma: a model for the treatment of other highly malignant neoplasms.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1986, Volume: 103

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma

1986
Disparate histologic responses in simultaneously resected primary and metastatic osteosarcoma following intravenous neoadjuvant chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Necrosis; Osteosarcoma; Postoperative Care; Preoperative Care; Vincristine

1987
Translocation t(9;11)(p21;q23) with acute myelomonocytic leukemia after chemotherapy for osteosarcoma: good response to antileukemic drugs.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 9; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma; Translocation, Genetic

1987
[The reproduction in France of Rosen's protocol for osteosarcomas].
    Bulletin du cancer, 1988, Volume: 75, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Prognosis

1988
[Experience with protocol T10 in the pediatric service at the Gustave-Roussy Institute].
    Bulletin du cancer, 1988, Volume: 75, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Prognosis

1988
[Preoperative systemic chemotherapy of patients with osteosarcoma: a preliminary study of nine cases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Male; Methotrexate; Osteosarcoma; Premedication

1989
[Mirror-image osteosarcoma of the radius. A case].
    Presse medicale (Paris, France : 1983), 1989, Jun-24, Volume: 18, Issue:25

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Follow-Up Studies; Humans; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma; Prognosis; Radius

1989
Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Arm; Bleomycin; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Female; Follow-Up Studies; Humans; Leg; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Premedication

1989
Secondary cerebral astrocytoma 3 years after diagnosis of primary osteogenic sarcoma: a case report.
    Pediatric hematology and oncology, 1987, Volume: 4, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bleomycin; Brain Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Electroencephalography; Femoral Neoplasms; Humans; Male; Methotrexate; Neoplasms, Multiple Primary; Osteosarcoma

1987
Methotrexate clearance and clinical toxicity in osteosarcoma following high-dose methotrexate therapy.
    JPMA. The Journal of the Pakistan Medical Association, 1989, Volume: 39, Issue:2

    Topics: Adolescent; Adult; Bone Neoplasms; Humans; Methotrexate; Osteosarcoma

1989
[Massive bone allografts in large bone defects after tumor surgery: a clinical long-term study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-3

    Topics: Bone Neoplasms; Bone Transplantation; Chondrosarcoma; Combined Modality Therapy; Doxorubicin; Femoral Neoplasms; Histiocytoma, Benign Fibrous; Humans; Methotrexate; Osteosarcoma; Postoperative Period; Sarcoma; Tibia

1989
Methotrexate diffusion from acrylic cement. Local chemotherapy for bone tumours.
    The Journal of bone and joint surgery. British volume, 1989, Volume: 71, Issue:5

    Topics: Animals; Bone Cements; Bone Neoplasms; Diffusion; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Implants; In Vitro Techniques; Methotrexate; Methylmethacrylates; Osteosarcoma; Rats; Time Factors

1989
[Spontaneous pneumothorax in patients with osteosarcoma treated by combined chemotherapy].
    Minerva medica, 1989, Volume: 80, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Doxorubicin; Extremities; Female; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pneumothorax; Time Factors; Vincristine

1989
[Individualization of the dosage of high-dose methotrexate by assaying plasma concentration. Therapeutic value in osteogenic sarcoma].
    Bulletin du cancer, 1989, Volume: 76, Issue:8

    Topics: Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Osteosarcoma; Time Factors

1989
Resistance to methotrexate and multidrug resistance in childhood malignancies.
    Advances in enzyme regulation, 1989, Volume: 29

    Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Child; DNA, Neoplasm; Drug Resistance; Female; Humans; Infant; Leukemia; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1989
Overall results of adjuvant chemotherapy and a chemosensitivity test for osteosarcoma.
    Clinical therapeutics, 1989, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Time Factors; Tumor Stem Cell Assay; Vincristine

1989
Drug resistance and cross-sensitivity in cultured human osteosarcoma cells.
    Nihon Seikeigeka Gakkai zasshi, 1989, Volume: 63, Issue:4

    Topics: Cisplatin; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Methotrexate; Osteosarcoma; Tumor Cells, Cultured; Vincristine

1989
Daily profiles of plasma phenylalanine and tyrosine in patients with osteogenic sarcoma during treatment with high-dose methotrexate-citrovorum rescue.
    Medical and pediatric oncology, 1989, Volume: 17, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Leg; Leucovorin; Male; Methotrexate; Osteosarcoma; Phenylalanine; Time Factors; Tyrosine

1989
[Management of the administration of leucovorin calcium in high-dose methotrexate therapy].
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:6

    Topics: Adult; Blood Cell Count; Bone Neoplasms; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1989
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
    Cancer research, 1989, Nov-01, Volume: 49, Issue:21

    Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Removal of methotrexate by hemodiafiltration.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:6

    Topics: Hemofiltration; Humans; Male; Mandibular Neoplasms; Methotrexate; Middle Aged; Osteosarcoma; Renal Dialysis

1989
Magnetic resonance imaging (MRI) in evaluating in vivo response to neoadjuvant chemotherapy for osteosarcomas of the extremities.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1989, Volume: 15, Issue:5

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Combined Modality Therapy; Female; Femur; Humans; Humerus; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma; Prospective Studies; Tibia; Tomography, X-Ray Computed

1989
MR findings in methotrexate-induced CNS abnormalities.
    AJR. American journal of roentgenology, 1989, Volume: 153, Issue:6

    Topics: Adolescent; Adult; Brain; Brain Diseases; Child; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Osteosarcoma

1989
The current management of malignant bone tumours: where do we go from here?
    The Medical journal of Australia, 1988, Apr-18, Volume: 148, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Histiocytoma, Benign Fibrous; Humans; Methotrexate; Osteosarcoma; Sarcoma, Ewing

1988
Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen.
    Lancet (London, England), 1986, Feb-01, Volume: 1, Issue:8475

    Topics: Adolescent; Adult; Aged; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ketoprofen; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Osteosarcoma; Phenylpropionates; Retrospective Studies; Time Factors

1986
Folinic acid rescue and methotrexate toxicity.
    Lancet (London, England), 1986, Mar-29, Volume: 1, Issue:8483

    Topics: Acute Kidney Injury; Adolescent; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma

1986
Enhancement of methotrexate nephrotoxicity after cisplatin therapy.
    Cancer, 1986, Dec-15, Volume: 58, Issue:12

    Topics: Acetylglucosaminidase; Adolescent; Adult; Aminopeptidases; Antineoplastic Combined Chemotherapy Protocols; Carrier Proteins; CD13 Antigens; Cisplatin; Dipeptidyl Peptidase 4; Humans; Kidney Tubules; Methotrexate; Osteosarcoma; Prospective Studies; Proteinuria

1986
Perioperative chemotherapy for primary sarcoma of bone.
    Canadian journal of surgery. Journal canadien de chirurgie, 1989, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Intraoperative Care; Male; Methotrexate; Osteosarcoma; Premedication; Vincristine

1989
[Treatment of osteogenic sarcoma].
    Gan no rinsho. Japan journal of cancer clinics, 1989, Volume: Spec No

    Topics: Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Hip Prosthesis; Humans; Joint Prosthesis; Lung Neoplasms; Methotrexate; Osteosarcoma; Prognosis

1989
[Osteogenic osteosarcoma, a model of a disease that is curable using a multidisciplinary treatment approach].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Volume: 182, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Osteosarcoma; Prostheses and Implants

1988
Breast cancer after treatment for osteosarcoma.
    Medical and pediatric oncology, 1986, Volume: 14, Issue:1

    Topics: Adenocarcinoma; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Lymph Node Excision; Lymphatic Metastasis; Mastectomy; Methotrexate; Osteosarcoma; Risk

1986
Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pentosyltransferases; Thymidine

1987
Blood-brain barrier disruption and methotrexate in the treatment of a readily transplantable intracerebral osteogenic sarcoma of rats.
    Cancer research, 1987, Dec-01, Volume: 47, Issue:23

    Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carotid Arteries; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Mannitol; Methotrexate; Neoplasm Transplantation; Osteosarcoma; Rats; Rats, Inbred Strains

1987
Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two alternating drug combinations and early prophylactic lung irradiation. French Bone Tumor Study Group.
    Cancer, 1988, Apr-01, Volume: 61, Issue:7

    Topics: Adolescent; Adult; Aging; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; Femoral Neoplasms; Fibula; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Mitomycin; Mitomycins; Osteosarcoma; Prognosis; Radiotherapy Dosage; Tibia; Time Factors; Vincristine

1988
[Angiographic evaluation of the response of osteosarcoma to neoadjuvant chemotherapy].
    La Radiologia medica, 1988, Volume: 75, Issue:4

    Topics: Adolescent; Angiography; Bone Neoplasms; Cisplatin; Female; Humans; Male; Methotrexate; Osteosarcoma

1988
[Experience with Rosen's T10 protocol at the Oscar Lambret Center (Lille) from 1982 to 1985. Apropos of 13 cases of non-metastatic osteosarcomas of the extremities].
    Annales de pediatrie, 1988, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Female; Femoral Neoplasms; Humans; Humerus; Male; Methotrexate; Osteosarcoma; Radius; Tibia

1988
[Chemotherapy of sarcomas in the adult].
    Bulletin du cancer, 1988, Volume: 75, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Sarcoma; Sarcoma, Ewing; Soft Tissue Neoplasms; Vincristine

1988
Neoadjuvant chemotherapy for osteosarcoma of the extremities. Good response of the primary tumor after preoperative chemotherapy with high-dose methotrexate followed by cisplatinum and adriamycin. Preliminary results.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1988, Volume: 7, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Female; Humans; Male; Methotrexate; Osteosarcoma

1988
Importance of age and methotrexate dosage: prognosis in children and young adults with high-grade osteosarcomas.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1988, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Prognosis

1988
The alteration in the pattern of pulmonary metastasis with adjuvant chemotherapy in osteosarcoma.
    International orthopaedics, 1988, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Prognosis

1988
The effects of methotrexate (MTX) on bone. A densitometric study conducted on 59 patients with MTX administered at different doses.
    Italian journal of orthopaedics and traumatology, 1988, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Bone and Bones; Bone Neoplasms; Child; Densitometry; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Minerals; Osteosarcoma

1988
Neoadjuvant chemotherapy in the treatment of osteosarcoma of the extremities: preliminary results in 131 cases treated preoperatively with methotrexate and cisdiamminoplatinum.
    Italian journal of orthopaedics and traumatology, 1988, Volume: 14, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Osteosarcoma; Prognosis; Random Allocation; Time Factors

1988
Renal insufficiency in patients treated with high dose methotrexate.
    Acta oncologica (Stockholm, Sweden), 1988, Volume: 27, Issue:1

    Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Combined Modality Therapy; Drug Interactions; Female; Humans; Iopamidol; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Osteosarcoma

1988
Methotrexate administered by 6-h and 24-h infusion: a pharmacokinetic comparison.
    Cancer chemotherapy and pharmacology, 1988, Volume: 22, Issue:1

    Topics: Child; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma

1988
Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion.
    Cancer, 1988, Sep-01, Volume: 62, Issue:5

    Topics: Adolescent; Female; Hemoperfusion; Humans; Leucovorin; Methotrexate; Osteosarcoma; Renal Dialysis; Tetrahydrofolates

1988
[High-dose methotrexate with citrovorum factor rescue (HD-MTX-CFR) in the treatment of malignant solid tumors--clinical analysis of 62 patients].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1988, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; Humans; Leucovorin; Lung Neoplasms; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma

1988
[Postoperative adjuvant chemotherapy of high dose MTX for osteogenic sarcoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1988, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Amputation, Surgical; Bone Neoplasms; Child; Combined Modality Therapy; Female; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Postoperative Care; Retrospective Studies; Tibia

1988
Combined chemotherapy and surgery for pulmonary metastases from osteogenic sarcoma. Results of 10 years experience.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1988, Volume: 2, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Postoperative Complications; Prospective Studies; Recurrence; Survival Rate

1988
[Autologous bone marrow transplantation in osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:5 Pt 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Bone Neoplasms; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Male; Melphalan; Methotrexate; Osteosarcoma; Transplantation, Autologous

1987
[Clinical effect of prostaglandin E1 on liver dysfunction due to high-dose methotrexate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:2

    Topics: Alprostadil; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Osteosarcoma

1988
Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
    Oncology, 1986, Volume: 43, Issue:2

    Topics: Child; Chromatography, High Pressure Liquid; Humans; Kinetics; Methotrexate; Osteosarcoma; Time Factors

1986
An improved synthesis of a methotrexate-albumin-791T/36 monoclonal antibody conjugate cytotoxic to human osteogenic sarcoma cell lines.
    Cancer research, 1986, Volume: 46, Issue:5

    Topics: Antibodies, Monoclonal; Cell Survival; Cells, Cultured; Humans; Hydrogen-Ion Concentration; Immunochemistry; Methotrexate; Osteosarcoma; Selenomethionine; Serum Albumin

1986
Methotrexate interferes with determinations of conjugated bilirubin with the Kodak Ektachem 400.
    Clinical chemistry, 1986, Volume: 32, Issue:5

    Topics: Autoanalysis; Bilirubin; False Positive Reactions; Humans; Methotrexate; Osteosarcoma; Spectrophotometry

1986
Phase II study of low-dose methotrexate in advanced osteosarcoma followed by escalation after disease progression: a study of the Soft Tissue and Bone Sarcoma Group of the European Organization for Research on Treatment of Cancer.
    Cancer treatment reports, 1986, Volume: 70, Issue:5

    Topics: Adolescent; Adult; Bone Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Osteosarcoma; Random Allocation; Time Factors

1986
Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: is a good response to preoperative treatment an indication to reduce postoperative chemotherapy?
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1986, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Doxorubicin; Extremities; Female; Femoral Neoplasms; Fibula; Humans; Humerus; Infant; Infant, Newborn; Infusions, Intra-Arterial; Injections, Intravenous; Male; Methotrexate; Necrosis; Osteosarcoma; Postoperative Care; Preoperative Care; Tibia; Time Factors

1986
Targeting of anti-cancer therapeutic agents by monoclonal antibodies.
    Biochemical Society transactions, 1986, Volume: 14, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cisplatin; Daunorubicin; Dosage Forms; Doxorubicin; Methotrexate; Mice; Osteosarcoma; Serum Albumin; Vindesine

1986
The influence of high-dose methotrexate therapy on serum iron.
    Klinische Wochenschrift, 1986, May-15, Volume: 64, Issue:10

    Topics: Adolescent; Adult; Bone Neoplasms; Dose-Response Relationship, Drug; Erythropoiesis; Female; Humans; Iron; Male; Methotrexate; Middle Aged; Osteosarcoma

1986
[Surgery and adjuvant chemotherapy of osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 2

    Topics: Adolescent; Antineoplastic Agents; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Postoperative Care; Preoperative Care

1986
Leukocytoclastic vasculitis after high-dose methotrexate.
    Annals of internal medicine, 1986, Volume: 105, Issue:3

    Topics: Humans; Male; Methotrexate; Middle Aged; Osteosarcoma; Vasculitis

1986
Chemosensitivity testing with tumor colony-forming assay for human osteosarcoma.
    The Japanese journal of antibiotics, 1986, Volume: 39, Issue:5

    Topics: Aclarubicin; Adolescent; Antineoplastic Agents; Bone Neoplasms; Child; Cisplatin; Colony-Forming Units Assay; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Naphthacenes; Osteosarcoma; Vincristine

1986
[In vivo 31P-NMR studies on energy metabolism and the effect of methotrexate in murine implanted osteosarcoma].
    Nihon Seikeigeka Gakkai zasshi, 1986, Volume: 60, Issue:7

    Topics: Animals; Drug Evaluation, Preclinical; Energy Metabolism; Female; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma

1986
Transient cerebral dysfunction secondary to high-dose methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Brain Diseases; Electroencephalography; Female; Glioma; Hodgkin Disease; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Paresis; Seizures; Syndrome

1986
[Results of the treatment of osteosarcoma at the National Children's Hospital of Costa Rica].
    Boletin medico del Hospital Infantil de Mexico, 1986, Volume: 43, Issue:9

    Topics: Adolescent; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Costa Rica; Cyclophosphamide; Disarticulation; Doxorubicin; Female; Humans; Injections, Intra-Arterial; Male; Methotrexate; Osteosarcoma; Preoperative Care; Prognosis; Vincristine

1986
Neoadjuvant high-dose methotrexate, cisplatin, and doxorubicin for the management of patients with nonmetastatic osteosarcoma.
    Cancer treatment reports, 1986, Volume: 70, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Extremities; Follow-Up Studies; Humans; Methotrexate; Osteosarcoma

1986
Conjugates of monoclonal antibody 791T/36 with methotrexate in cancer therapy.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Evaluation Studies as Topic; Flow Cytometry; Humans; Methotrexate; Mice; Neoplasm Transplantation; Osteosarcoma; Serum Albumin; Tumor Stem Cell Assay

1987
Renal toxicity with cumulative doses of cis-diamminedichloroplatinum-II in pediatric patients with osteosarcoma. Effect on creatinine clearance and methotrexate excretion.
    Cancer, 1987, May-01, Volume: 59, Issue:9

    Topics: Child; Cisplatin; Creatine; Dose-Response Relationship, Drug; Humans; Kidney Diseases; Methotrexate; Osteosarcoma

1987
Continuous cisplatin infusion in combination with vincristine and high-dose methotrexate for advanced osteogenic sarcoma.
    American journal of clinical oncology, 1987, Volume: 10, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Humans; Infusions, Intravenous; Lymphatic Metastasis; Methotrexate; Osteosarcoma; Time Factors; Vincristine

1987
Cerebellar sclerosis in pediatric cancer patients.
    Journal of neuro-oncology, 1987, Volume: 4, Issue:4

    Topics: Cerebellum; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Retrospective Studies; Sclerosis

1987
Urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations predict impaired excretion of methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:5

    Topics: Acetylglucosaminidase; Adolescent; Adult; Child; Cisplatin; Creatinine; Half-Life; Hexosaminidases; Humans; Kidney Diseases; Methotrexate; Osteosarcoma

1987
[Rationale of preoperative chemotherapy of osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:5 Pt 2

    Topics: Adult; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Methotrexate; Osteosarcoma; Preoperative Care

1987
[Limb salvage in osteosarcoma. Significance of preoperative isolation perfusion chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:5 Pt 2

    Topics: Adolescent; Adult; Aged; Bone Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Child; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Hyperthermia, Induced; Male; Methotrexate; Middle Aged; Osteosarcoma; Preoperative Care; Prognosis

1987
Doxorubicin and methotrexate on a weekly schedule in patients with sarcomas.
    Oncology, 1987, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Administration Schedule; Female; Fibrosarcoma; Humans; Leiomyosarcoma; Liposarcoma; Male; Methotrexate; Middle Aged; Neurofibroma; Osteosarcoma; Rhabdomyosarcoma; Sarcoma; Time Factors

1987
Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's Hospital--study III.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:8

    Topics: Actuarial Analysis; Adolescent; Adult; Amputation, Surgical; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Doxorubicin; Female; Humans; Male; Methotrexate; Osteosarcoma; Prognosis

1987
Methotrexate test-dose protocol in the presence of 7-hydroxy-methotrexate.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Head and Neck Neoplasms; Humans; Hydroxylation; Infusions, Intravenous; Injections, Intravenous; Methotrexate; Middle Aged; Osteosarcoma

1987
[Bone cement containing cytostatic drugs: new aspects in the treatment of malignant bone tumors. I. Experimental studies].
    Langenbecks Archiv fur Chirurgie, 1987, Volume: 371, Issue:2

    Topics: Animals; Bone and Bones; Bone Cements; Bone Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Methylmethacrylate; Methylmethacrylates; Mice; Neoplasm Transplantation; Osteosarcoma

1987
[Methotrexate poisoning: value of exchange transfusion].
    Pediatrie, 1987, Volume: 42, Issue:4

    Topics: Acute Kidney Injury; Child; Exchange Transfusion, Whole Blood; Humans; Leukopenia; Male; Methotrexate; Osteosarcoma; Thrombocytopenia

1987
[Early discovery and nursing of adverse effects associated with administration of massive dosages of MTX].
    Kangogaku zasshi, 1987, Volume: 51, Issue:12

    Topics: Adolescent; Bone Neoplasms; Humans; Male; Medication Errors; Methotrexate; Osteosarcoma

1987
[Experimental study on osteosarcoma of local chemotherapy diffusing from surgical acrylic cement and plaster].
    Revue de chirurgie orthopedique et reparatrice de l'appareil moteur, 1987, Volume: 73, Issue:7

    Topics: Animals; Antineoplastic Agents; Bone Cements; Casts, Surgical; Cisplatin; Dogs; Doxorubicin; Drug Implants; Humans; Methacrylates; Methotrexate; Osteosarcoma; Rats; Research Design; Sarcoma, Experimental

1987
[Osteosarcoma of the leg; treatment results following preoperative chemotherapy].
    Nederlands tijdschrift voor geneeskunde, 1986, Mar-22, Volume: 130, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Postoperative Care; Premedication

1986
[Neo-adjuvant therapy in childhood osteogenic sarcoma: a pilot study of selective postoperative chemotherapy based on response to preoperative high-dose methotrexate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:5

    Topics: Adjuvants, Immunologic; Adolescent; Bone Neoplasms; Child; Drug Administration Schedule; Female; Humans; Leucovorin; Male; Methotrexate; Osteosarcoma; Pilot Projects; Preoperative Care

1986
Sensitivity and selectivity of ricin toxin A chain-monoclonal antibody 791T/36 conjugates against human tumor cell lines.
    Cancer research, 1986, Volume: 46, Issue:11

    Topics: Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specificity; Binding, Competitive; Cell Line; Cell Survival; Humans; Immunotoxins; Methotrexate; Osteosarcoma; Ricin; Time Factors

1986
Experimental studies on high-dose methotrexate with citrovorum factor chemotherapy for 89Sr-induced osteosarcoma murine model.
    The Japanese journal of antibiotics, 1986, Volume: 39, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Injections, Intraperitoneal; Injections, Intravenous; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Osteosarcoma; Strontium Radioisotopes

1986
Pathologic fracture in osteosarcoma. Impact of chemotherapy on primary tumor and survival.
    Cancer, 1987, Feb-15, Volume: 59, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Fractures, Spontaneous; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Osteosarcoma

1987
[Spectral EEG analysis in children treated with high-dose methotrexate].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 1

    Topics: Bone Neoplasms; Child; Child, Preschool; Electroencephalography; Female; Humans; Infusions, Intravenous; Leucovorin; Lymphoma; Male; Methotrexate; Osteosarcoma

1987
[Significance of surgical adjuvant chemotherapy in osteosarcoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:5 Pt 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Humans; Leucovorin; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Postoperative Care

1987
[Compatibility and toxicity of methotrexate in the treatment of bone tumors].
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:4

    Topics: Bone Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma

1987
High-dose methotrexate therapy with leucovorin rescue: in vitro investigations on human osteosarcoma cell lines.
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:2

    Topics: Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Humans; Leucovorin; Methotrexate; Osteosarcoma; Thymidine; Tumor Cells, Cultured

1987
7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy.
    Journal of cancer research and clinical oncology, 1985, Volume: 109, Issue:1

    Topics: Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans; Methotrexate; Osteosarcoma; Time Factors

1985
Dosage predictions in high-dose methotrexate infusions. Part 1: Evaluation of the classic test-dose protocol.
    Cancer drug delivery, 1985,Fall, Volume: 2, Issue:4

    Topics: Head and Neck Neoplasms; Humans; Kinetics; Mathematics; Methotrexate; Osteosarcoma; Sarcoma; Time Factors

1985
Primary osteogenic sarcoma of the skull. Five-year disease-free survival following surgery and high dose methotrexate therapy.
    New York state journal of medicine, 1985, Volume: 85, Issue:10

    Topics: Female; Humans; Methotrexate; Osteosarcoma; Postoperative Care; Skull Neoplasms

1985
[Delayed excretion of high doses of methotrexate].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1985, Nov-30, Volume: 105, Issue:33

    Topics: Adolescent; Dose-Response Relationship, Drug; Humans; Kidney; Male; Methotrexate; Osteosarcoma

1985
Response of osteosarcoma to preoperative intravenous high-dose methotrexate chemotherapy: CT evaluation.
    AJR. American journal of roentgenology, 1985, Volume: 144, Issue:1

    Topics: Adolescent; Amputation, Surgical; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Extremities; Female; Humans; Injections, Intravenous; Male; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed

1985
Control of primary osteosarcoma with chemotherapy.
    Cancer, 1985, Aug-01, Volume: 56, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Ilium; Infusions, Intra-Arterial; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Tibia

1985
Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Child; Humans; Kinetics; Leucovorin; Methotrexate; Osteosarcoma; Retrospective Studies

1985
Transient neurologic disturbances induced by high-dose methotrexate treatment.
    Cancer, 1985, Sep-15, Volume: 56, Issue:6

    Topics: Bone Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma

1985
[Clinical significance of non-renal elimination mechanisms of methotrexate (MTX)].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1985, Volume: 133, Issue:8

    Topics: Abdominal Neoplasms; Adolescent; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bile; Child; Child, Preschool; Cholestyramine Resin; Chromatography, High Pressure Liquid; Enterohepatic Circulation; Female; Femoral Neoplasms; Humans; Kinetics; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma

1985
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-fluorouracil in solid tumors.
    Cancer, 1969, Volume: 23, Issue:3

    Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Fibrosarcoma; Fluorouracil; Humans; Leiomyosarcoma; Male; Melanoma; Methotrexate; Middle Aged; Neoplasm Metastasis; Osteosarcoma; Pancreatic Neoplasms; Pharyngeal Neoplasms; Prognosis; Sarcoma; Sarcoma, Synovial; Vincristine

1969
The use of oral methotrexate (mtx) in the treatment of tumours in the head and neck-region.
    Archivum chirurgicum Neerlandicum, 1970, Volume: 22, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Aged; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cystadenoma; Ear Neoplasms; Female; Head; Head and Neck Neoplasms; HeLa Cells; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Osteosarcoma

1970
Blood and neoplastic diseases. Solid tumours in children.
    British medical journal, 1974, Dec-21, Volume: 4, Issue:5946

    Topics: Adolescent; Biopsy; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Diagnosis, Differential; Doxorubicin; Hodgkin Disease; Humans; Infant; Methods; Methotrexate; Neoplasms; Neuroblastoma; Nitrogen Mustard Compounds; Osteosarcoma; Prednisolone; Prognosis; Radiography; Retinoblastoma; Rhabdomyosarcoma; Sarcoma, Ewing; Vincristine; Wilms Tumor

1974
Recent advances in the chemotherapy of metastatic osteogenic sarcoma.
    Cancer, 1972, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Child; Humans; Leucovorin; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1972
Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy.
    Cancer, 1973, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Bone Marrow; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Kidney; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Radiotherapy Dosage; Skin; Stomatitis

1973
High-dose methotrexate with citrovorum factor rescue and adriamycin in childhood osteogenic sarcoma.
    Cancer, 1974, Volume: 33, Issue:4

    Topics: Adolescent; Age Factors; Alkaline Phosphatase; Aspartate Aminotransferases; Bone Neoplasms; Child; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Hematopoietic System; Humans; Leucovorin; Male; Methotrexate; Mucous Membrane; Nausea; Neoplasm Metastasis; Osteosarcoma

1974
Editorial: A giant step forward - if....
    The New England journal of medicine, 1974, Nov-07, Volume: 291, Issue:19

    Topics: Amputation, Surgical; Doxorubicin; Drug Therapy, Combination; Humans; Leucovorin; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Osteosarcoma

1974
Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-"leucovorin rescue" for children with malignant tumors.
    Cancer research, 1974, Volume: 34, Issue:12

    Topics: Adolescent; Age Factors; Aspartate Aminotransferases; Child; Child, Preschool; Female; Half-Life; Hematopoiesis; Humans; Kidney; Leucovorin; Liposarcoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Rhabdomyosarcoma; Sarcoma, Ewing; Teratoma

1974
Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.
    American journal of surgery, 1972, Volume: 124, Issue:4

    Topics: Antineoplastic Agents; Brachial Artery; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Artery, Internal; Catheterization; Cyclophosphamide; Dactinomycin; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Melanoma; Methods; Methotrexate; Mouth Neoplasms; Neoplasms; Osteosarcoma; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms; Skull Neoplasms; Vinblastine

1972
[A new combination of methotrexate and folinic acid for cancer treatment (acute leukemia and solid tumors)].
    La Presse medicale, 1969, Mar-01, Volume: 77, Issue:11

    Topics: Agranulocytosis; Antineoplastic Agents; Breast Neoplasms; Female; Hemangiosarcoma; Hodgkin Disease; Humans; Kidney Neoplasms; Leucovorin; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Osteosarcoma; Pancreatic Neoplasms; Radiography; Rectal Neoplasms; Rhabdomyosarcoma; Testicular Neoplasms; Thrombocytopenia

1969
Regional chemotherapeutic perfusion and infusion of brain and face tumors.
    Annals of surgery, 1967, Volume: 166, Issue:2

    Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Ethylenediamines; Facial Neoplasms; Fibrosarcoma; Glioma; Humans; Infusions, Parenteral; Mechlorethamine; Melanoma; Melphalan; Meningioma; Methotrexate; Osteosarcoma; Perfusion; Quinones; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Thiotepa

1967