methotrexate has been researched along with Neutropenia in 220 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (14.55) | 18.7374 |
| 1990's | 66 (30.00) | 18.2507 |
| 2000's | 57 (25.91) | 29.6817 |
| 2010's | 54 (24.55) | 24.3611 |
| 2020's | 11 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chua, C; Cooke, R; Doig, C; Leung, T | 1 |
| Ahmad, S; Bano, N; Karwasra, R; Qazi, S; Raza, K; Singh, S; Varma, S | 1 |
| Burmester, GR; Fleischmann, R; Hu, CC; Kivitz, AJ; Klier, GL; Strand, V; van Hoogstraten, H; Wang, S | 1 |
| Lyu, H; Solomon, DH; Vanni, KMM | 1 |
| Komori, K; Kurata, T; Minami, K; Nakamura, T; Saito, S; Sakashita, K; Uchida, E; Watanabe, T; Yanagisawa, R | 1 |
| Cortazar, FB; Huizenga, NR; Laliberte, K; Niles, JL; Rhee, EP; Rosenthal, JM; Wallace, ZS; Zonozi, R | 1 |
| Chen, ZB; Ding, CC; Liu, S; Qu, Q; Wang, GQ; Wen, FQ; Zhan, M | 1 |
| Combe, B; Espinoza, F; Le Blay, P | 1 |
| Cacciavillano, W; Rose, A; Scopinaro, M; Villegas Rubio, JA; Zubizarreta, P | 1 |
| Lee, EB | 1 |
| Bompas, E; Bouvier, C; Brisse, HJ; Brugieres, L; Castex, MP; Cheurfa, N; Corradini, N; Delaye, J; Entz-Werlé, N; Gaspar, N; Gentet, JC; Italiano, A; Le Deley, MC; Lervat, C; Marec-Berard, P; Mascard, E; Occean, BV; Pacquement, H; Piperno-Neumann, S; Redini, F; Saumet, L; Schmitt, C; Tabone, MD; Verite-Goulard, C | 1 |
| Gunasekera, CN; Herath, HMMTB; Janappriya, GHCC; Keragala, BSDP; Kulatunga, A; Pahalagamage, SP | 1 |
| Kwon, WA; Lee, JW; Oh, TH; Park, SC; Seo, IY | 1 |
| Graham, NMH; Hagino, O; Kameda, H; Takahashi, Y; Tanaka, Y; van Hoogstraten, H; Wada, K | 1 |
| Corfield, G; Fung, P; Heneghan, D; Kitchen, J; Malley, T | 1 |
| Carbajales, M; Fernández, B; Fernández, R; Labeaga, Y; Pampín, R; Rodríguez, B | 1 |
| Giagounidis, A; Haase, S; Mitsimponas, N; Mitsogianni, M | 1 |
| Arai, H; Boku, N; Fukuda, N; Hironaka, S; Iwasa, S; Kawahira, M; Masuishi, T; Minashi, K; Muro, K; Nakajima, TE; Takahari, D; Yasui, H | 1 |
| Burmester, GR; Fleischmann, R; Genovese, MC; Gomez-Reino, JJ; Kivitz, AJ; Lin, Y; Maldonado-Cocco, JA; St John, G; Stanislav, M; van der Heijde, D; Wang, S | 1 |
| Brenner, A; Butler, MJ; Faivre, G; Le, I | 1 |
| Aalto, K; Backström, M; Grönlund, MM; Kröger, L; Markula-Patjas, K; Putto-Laurila, A; Remes-Pakarinen, T; Vähäsalo, P | 1 |
| Bubik, RJ; Oravec, CP; Osmon, DR; Rivera, CG | 1 |
| Donmez, S; Keystone, EC; Kisacik, B; Onat, AM; Pamuk, GE; Pamuk, ON; Pehlivan, Y; Sayarlioglu, M | 1 |
| Boku, N; Denda, T; Doi, T; Fukuda, H; Goto, M; Hamamoto, Y; Nasu, J; Ohtsu, A; Shirao, K; Takashima, A; Yamada, Y; Yamaguchi, K | 1 |
| Fukano, R; Inagaki, J; Kodama, Y; Nishimura, M; Okamura, J; Shimokawa, M | 1 |
| Bernhardt, MB; Brackett, J; Leung, DH; Schafer, ES | 1 |
| Biasoni, D; Catanzaro, M; De Braud, FG; Farè, E; Giannatempo, P; Gianni, AM; Maffezzini, M; Mariani, L; Necchi, A; Nicolai, N; Piva, L; Pizzocaro, G; Raggi, D; Salvioni, R; Stagni, S; Torelli, T | 1 |
| Bai, B; Cai, QC; Cai, QQ; Gao, Y; Huang, HQ; Jiang, WQ; Wang, XX; Xia, YF; Xia, ZJ | 1 |
| Adamkovich, N; Bagdi, E; Borbényi, Z; Kispál, M; Krenács, L | 1 |
| Cheng, J; Lamy, T; Loughran, TP; Malysz, J; Ochmann, M; Talamo, G | 1 |
| Brion, A; Chabin, M; Clavert, A; Colombat, P; Cumin, I; Delwail, V; Escoffre-Barbe, M; Gardembas, M; Ingrand, P; Lacotte-Thierry, L; Legouffe, E; Olivier, G; Solal-Celigny, P | 1 |
| Bennett, JM; Evens, AM; Hasanali, Z; Lazarus, HM; Litzow, MR; Loughran, TP; Mustjoki, S; Olson, TL; Rajala, HL; Tallman, MS; Wang, V; Zhang, D; Zickl, L | 1 |
| Hasegawa, D; Iwata, A; Kawaguch, K; Kobayashi, M; Kosaka, Y; Matsubara, K; Miyata, K; Nigami, H; Saito, A; Uchida, Y | 1 |
| Chan, KK; Chu, MM; Ma, Y; Ngan, HY; Tse, KY | 1 |
| Fan, C; Fiore, S; Fleischmann, R; Garg, A; Genovese, MC; Graham, NM; Huizinga, TW; Kivitz, AJ; Martincova, R; Rell-Bakalarska, M; Rohane, P; Stahl, N; van Adelsberg, J; van der Heijde, D; van Hoogstraten, H; Weinstein, SP; Yancopoulos, GD | 1 |
| Frandsen, T; Nersting, J; Rosthøj, S; Schmiegelow, K; Vang, SI | 1 |
| Corominas, H; de la Serna, AR; Díaz-Torné, C; Hernández, MV; Llobet, JM; Magallares, B; Narváez, J; Nolla, JM; Reina, D; Sanmartí, R | 1 |
| Afanasyev, B; Al Seraihy, A; Aljurf, M; Ancliff, P; Bierings, M; Calvillo, M; de Wreede, L; Donadieu, J; Dufour, C; Fioredda, F; Fischer, A; Ganser, A; Gaspar, B; Iacobelli, S; Kalwak, K; Ljungman, P; Marsh, J; Matthes-Martin, S; Morreale, G; Or, R; Ozturk, G; Peffault de Latour, R; Peters, C; Sánchez de Toledo Codina, J; Smith, O; van 't Veer-Tazelaar, N; van Biezen, A; Veys, P; Wynn, R; Yesilipek, A | 1 |
| Agular, B; Gröndal, G; Hansen, I; Jensen, EC; Johansen, P; Juul, L; Lindegaard, HM; Schlemmer, AM | 1 |
| Hidaka, M; Hidaka, T; Kawakita, T; Migita, K; Mori, S; Tsuda, H; Ueki, Y; Yoshitama, T | 1 |
| Ambrosetti, A; Balzarotti, M; Binder, M; Cavalli, F; Cwynarski, K; Deckert, M; Fabbri, A; Ferrari, A; Ferreri, AJ; Finke, J; Fox, CP; Gørløv, JS; Hemmaway, C; Hertenstein, B; Hess, G; Illerhaus, G; Johnson, P; Keller, U; Krause, SW; Levis, A; Linton, KM; Panse, J; Pisani, F; Politi, LS; Ponzoni, M; Pukrop, T; Pulczynski, E; Reni, M; Rosée, PL; Roth, A; Rudà, R; Schmoll, HJ; Schorb, E; Stilgenbauer, S; Torri, V; Tucci, A; Zucca, E | 1 |
| Choi, YJ; Kang, CH; Kim, KW; Park, JH; Park, KH; Ro, KH; Song, SH | 1 |
| Bauer, D; Burmester, GR; Graham, NM; Ignacio Vargas, J; Lee, EB; Lin, Y; Mangan, EK; Patel, R; van Adelsberg, J; van Hoogstraten, H | 1 |
| Boku, N; Fukuda, H; Hamaguchi, T; Honma, H; Hyodo, I; Imamura, T; Koizumi, W; Mukai, T; Ohtsu, A; Seki, S; Shirao, K; Yamamichi, N; Yamamoto, S; Yoshida, S | 1 |
| Schmiegelow, K; Schroeder, H; van Kooten Niekerk, PB | 1 |
| Beverloo, HB; Cornelissen, JJ; Deenik, W; Valk, PJ; van der Poel-van de Luytgaarde, SC; van Esser, JW; Wattel, MM | 1 |
| Gennatas, K; Gennatas, S; Michalaki, V | 1 |
| Kawakami, M; Omori, H; Soma, T; Yamagami, T | 1 |
| Caron, HN; Hesseling, P; Israëls, T; Molyneux, EM; van de Wetering, MD; van Geloven, N | 1 |
| Jager, A; Sleijfer, S; Verweij, J | 1 |
| Chapman, PT; Frampton, C; James, J; O'Donnell, JL; Stamp, LK; White, DH | 1 |
| Hosone, M; Isobe, Y; Katsuoka, Y; Komatsu, N; Oshimi, K; Shimizu, S; Sugimoto, K; Tsukune, Y; Yasuda, H | 1 |
| Bacon, P; Casas, A; Castellanos, J; Duque, A; Falcone, A; Gridelli, C; Lawrinson, S; Mansutti, M; Mattioli, R; Skacel, T | 1 |
| Abeloff, MD; Albain, KS; Ambrosone, CB; Barlow, WE; Choi, JY; Davis, W; Hayes, DF; Hortobagyi, GN; Hutchins, LF; Livingston, RB; Lyss, AP; Martino, S; Osborne, CK; Rae, JM; Ravdin, PM; Yao, S; Yeh, IT; Zhao, H | 1 |
| Jones, G | 1 |
| Koo, YX; Lai, GG; Lim, ST; Tan, TT; Tao, M | 1 |
| Lamy, T; Loughran, TP | 1 |
| Cui, L; Gao, C; Li, WJ; Li, ZG; Liu, SG; Zhao, XX | 1 |
| Kalpadakis, C; Papadaki, HA; Pontikoglou, C | 1 |
| Bari, M; Ciruelos, E; De Benedictis, E; Dittrich, C; Gaion, F; Gomez, P; Lluch, A; Luca, G; Mansutti, M; Morandi, P; Pavesi, L; Semiglazov, V; Valagussa, P; Zamagni, C; Zambetti, M | 1 |
| Belmont-Gómez, A; Carvajal-Valencia, JA; Chacón-Solís, RA; Estrada-Altamirano, A; Hernández-Pacheco, JA; Maya-Quiñones, JL; Valenzuela-Jirón, A | 1 |
| Bareford, D; Pace, AV; Wyre, J | 1 |
| Abedin, S; Kapoor, G; Sinha, R | 1 |
| Fukushima, N; Hasegawa, Y; Hashimoto, C; Hyo, R; Ishida, F; Isobe, Y; Ito, Y; Izutsu, K; Kawa, K; Kimura, H; Kobayashi, H; Maeda, Y; Nakamura, S; Okamura, S; Oshimi, K; Suzuki, R; Suzumiya, J; Takizawa, J; Yamaguchi, M | 1 |
| Billett, AL; Billups, CA; Donaldson, SS; Friedmann, A; Howard, SC; Hudson, MM; Krasin, MJ; Kun, LE; Larsen, EC; Link, MP; Marcus, KJ; Metzger, ML; Tarbell, N; Weinstein, HJ; Wu, J; Yock, TI | 1 |
| Ambinder, RF; Bolaños-Meade, J; Borowitz, MJ; Brodsky, RA; Carraway, HE; Cho, SY; Crilley, PA; Gladstone, DE; Huff, CA; Jones, RJ; Kasamon, YL; Matsui, WH; Smith, BD; Swinnen, LJ; Tsai, HL | 1 |
| Dasari, P; Sagili, H | 1 |
| Hatta, Y; Hirabayashi, Y; Hojo, A; Horikoshi, A; Iriyama, N; Kiso, S; Kobayashi, S; Kobayashi, Y; Kodaira, H; Kura, Y; Kurita, D; Kusuda, M; Miura, K; Nakagawa, M; Sawada, U; Takahashi, H; Takeuchi, J; Uchino, Y; Yagi, M; Yamazaki, T | 1 |
| Brachemi, S; Déziel, C; Goupil, R; Lavergne, V; Nadeau-Fredette, AC; Troyanov, S; Troyanov, Y | 1 |
| Baildam, E; Brunner, HI; Burgos-Vargas, R; Calvo, I; Cuttica, R; De Benedetti, F; Dolezalova, P; Garay, SM; Grom, A; Joos, R; Kenwright, A; Lovell, D; Martini, A; Merino, R; Ravelli, A; Ruperto, N; Schneider, R; Woo, P; Wouters, C; Wright, S; Wulffraat, N; Xavier, R; Zemel, L; Zuber, Z; Zulian, F | 1 |
| Abrams, K; Berkun, Y; Brik, R; Brunner, HI; Calvo, I; Cimaz, R; Constantin, T; Erguven, M; Ferrandiz, MA; Flato, B; Gamir, ML; Goffin, L; Grom, A; Hofer, M; Horneff, G; Kallinich, T; Kasapcopur, O; Kim, D; Kone-Paut, I; Lheritier, K; Lovell, DJ; Magnusson, B; Martini, A; McCann, L; Nistala, K; Oliveira, SK; Ozen, S; Quartier, P; Ruperto, N; Rutkowska-Sak, L; Schneider, R; Sztajnbok, F; Uziel, Y; Viola, S; Wouters, C; Wulffraat, N | 1 |
| Balbir-Gurman, A; Hayek, T; Hoffman, R; Rozin, A | 1 |
| Bernhard, V; Feller, AC; Hochhaus, A; Krokowski, M; Mügge, LO; Neumann, T; Oelzner, P; Schrenk, KG; Wolf, G | 1 |
| Baselga, J; Bellmunt, J; Clèries, R; Cos, J; Eres, N; Margarit, C; Murio, JE; Pérez, M; Ribas, A | 1 |
| Achard, JL; Charrier, S; Chollet, P; Cure, H; Dauplat, J; De Latour, M; Feillel, V; Ferriere, JP; Le Bouedec, G; Leduc, B; Van Praagh, I | 1 |
| Bevan, J; Homer, D; Jobanputra, P; Maggs, F | 1 |
| Gowda, RV; Stout, R | 1 |
| Arellano-Rodrigo, E; Bessell, EM; Graus, F; López-Guillermo, A; Montserrat, E; Nomdedeu, B | 1 |
| Coppo, P; Desablens, B; Goetz, J; Gouilleux-Gruart, V; Lassoued, K; Maloisel, F; Schlageter, MH; Sibilia, J; Tribout, B; Voyer, AL | 1 |
| Grove, ML | 1 |
| Mikamo, H; Ninomiya, M; Tamaya, T | 1 |
| Cameron, DA; Kerr, G; Leonard, RC; Massie, C | 1 |
| Aravantinos, G; Bafaloukos, D; Bamias, A; Bamias, C; Deliveliotis, C; Dimopoulos, MA; Gika, D; Kalofonos, C; Kosmidis, P; Kourousis, C; Koutras, A; Mitropoulos, D; Papadimitriou, C; Papakostas, P; Pectasides, D; Samantas, E; Xiros, N; Zervas, A | 1 |
| Dawson, NA; Edelman, MJ; Houston, J; Lara, PN; Lauder, I; Law, LY; Meyers, FJ | 1 |
| Chess, JA; Mikhail, AI; Scholey, G | 1 |
| Gandhok, N; Sartor, O | 1 |
| Komatsu, H; Matsuzaki, M; Morikawa, H; Nakanishi, S; Nakano, M | 1 |
| Bamias, A; Bozas, G; Dimopoulos, MA; Efstathiou, E; Gika, D; Hamilos, G; Kakoyiannis, C; Kastritis, E; Moulopoulos, LA; Papadimitriou, C; Zorzou, MP | 1 |
| Barrios, L; Poletti, OH | 1 |
| Lesesve, JF; Mansuy, L | 1 |
| Calcino, LJ; Hill, RL; McEwen, J; Purcell, PM; Riley, CG | 1 |
| Balduzzi, A; Cardillo, A; Colleoni, M; Ghisini, R; Goldhirsch, A; Orlando, L; Peruzzotti, G; Pietri, E; Rocca, A; Torrisi, R | 1 |
| Katori, H; Taguchi, T; Tsukuda, M | 1 |
| Abella, E; Bethencourt, C; Brunet, S; Debén, G; del Potro, E; Feliu, E; Hernández-Rivas, JM; López, R; Morgades, M; Novo, A; Oriol, A; Ortega-Rivas, F; Ortín, X; Ribera, JM; Sancho, JM; Sanz, MA; Tormo, M; Xicoy, B | 1 |
| Glantz, M; Przekop, AA; Przekop, PR; Tulgan, H | 1 |
| Abe, Y; Imataki, O; Kawakami, K; Kusafuka, K; Tamai, Y | 1 |
| Hirobe, M; Honma, I; Itoh, N; Maeda, T; Masumori, N; Takahashi, A; Tsukamoto, T | 1 |
| Azuma, K; Hashine, K; Miura, N; Numata, K; Sumiyoshi, Y | 1 |
| Akutsu, M; Inoue, K; Izumi, T; Kano, Y; Katano, S; Kobayashi, H; Masuda, Y; Muroi, K; Nagashima, T; Ohmine, K; Ozawa, K; Shirai, T; Takagi, S; Tsunoda, S; Ueda, M; Ueda, T | 1 |
| Gorlick, R; Kellick, M; Meyers, PA; Wexler, LH; Zelcer, S | 1 |
| Cheng, KK | 1 |
| Amano, K; Matsui, H; Nakamura, H; Nakamura, K; Yamasaki, M | 1 |
| Baum, E; Bleyer, WA; Fryer, C; Griffin, T; Lampkin, B; Lukens, J; Morgan, E; Movassaghi, N; Provisor, A; White, H | 1 |
| Carey, RW; Cuttner, J; Ellison, RR; Gottlieb, AJ; Henderson, ES; Levy, RN; Rafla, S; Silver, RT; Terebelo, H; Weinberg, V | 1 |
| Kalliomäki, JL; Korvenranta, H; Meurman, L; Nikoskelainen, J; Rajamäki, A; Söderström, KO; Toivanen, A | 1 |
| Aboud, A; Blumenschein, GR; Buzdar, AU; Hortobagyi, GN; Yap, HY | 1 |
| Edwards, BK; Janus, C; Magrath, IT; Sariban, E | 1 |
| Jacobs, C | 1 |
| Barkley, HT; Benjamin, RS; Bodey, GP; Ertel, M; Freeman, MB; Mountain, CF; Smith, TL; Valdivieso, M | 1 |
| Bodey, GP; Cabanillas, F; Freireich, EJ; Hagemeister, FB | 1 |
| Cancelas, JA; Cerveró, C; García-Laraña, J; López, J; Navarro, JL; Odriozola, J; Pérez-Oteyza, J; Sánchez-Sousa, A; Sastre, JL | 1 |
| Ciaccia, D; Corey, GR; Peters, W; Thel, MC; Vredenburgh, JJ | 1 |
| Angus, B; Carey, P; Evans, RG; Jackson, GH; Lennard, AL; Lucraft, H; Proctor, SJ; Taylor, PR | 1 |
| Antman, K; Ayash, L; Elias, AD; Frei, E; Mazanet, R; Schnipper, L; Schwartz, G; Tepler, I; Wheeler, C | 1 |
| Begley, CG; Boyd, AW; Grigg, AP; Lickliter, JD; Szer, J | 1 |
| Fujimoto, N; Higuchi, M; Kawamura, M; Kuni-Eda, Y; Kurosawa, M; Maekawa, I; Morioka, M; Ohmura, T; Okabe, M; Suzuki, S | 1 |
| Busch, FW; Ganser, A; Gracien, E; Heil, G; Hoelzer, D; Kelly, K; Lipp, T; Ottmann, OG; Reutzel, R; Schwonzen, M | 1 |
| De Witte, T; Dompeling, EC; Schattenberg, A; Swaak, AJ; Vreugdenhil, G | 1 |
| Bonnem, E; Levine, A; Melendez, D; Rarick, M; Shelton, B; Thompson, J; Walsh, C; Wernz, JC; Willson, E | 1 |
| Bettelheim, P; Geissler, K; Gisslinger, H; Jäger, U; Kyrle, PA; Laczika, K; Locker, G; Scherrer, R; Scholten, C; Sillaber, C | 1 |
| Soper, BD; Tepperman, BL; Vozzolo, BL | 1 |
| Ballestrero, A; Basta, P; Brema, F; Ferrando, F; Ghio, R; Gobbi, M; Moraglio, L; Patrone, F; Sessarego, M; Valbonesi, M | 1 |
| Abgrall, JF; Attal, M; Boasson, M; Bourhis, JH; Caillot, D; Divine, M; Harousseau, JL; Leblond, V; Marit, G; Stoppa, AM | 1 |
| Brunner, V; Bugat, R; Canal, P; Chatelut, E; Chevreau, C; Houin, G; Martinez, M | 1 |
| Aoyama, Y; Kameyama, Y; Nishiyama, H; Noguchi, T; Yoshinari, N | 1 |
| Hosaka, M; Kondoh, K; Kubota, Y; Masuda, M; Misaki, H; Noguchi, S; Sakuramoto, T; Shuin, T; Yao, M | 1 |
| Bannwarth, B; Dehais, J; Marcé, S; Schaeverbeke, T | 1 |
| Kohsaka, T; Kumazawa, M; Nakamura, H; Yamasaki, M | 1 |
| Ali, AA; Alvi, AA; Iqbal, MP | 1 |
| Greco, FA; Hainsworth, JD; Johnson, DH; Lamar, RE; Murphy, PB | 1 |
| Aglietta, M; Carnino, F; Gavosto, F; Monzeglio, C; Pasquino, P; Stern, AC | 1 |
| Bonadonna, G; Brambilla, C; Ferrari, L; Passoni, P | 1 |
| Mempel, K; Pfetsch, M; Reiter, A; Riehm, H; Schrappe, M; Schwab, G; Welte, K | 1 |
| Adde, M; Arndt, C; Gootenberg, J; Horak, ID; Jaffe, E; Magrath, I; Neely, J; Nieder, M; Seibel, N; Shad, A; Venzon, D; Wittes, RA | 1 |
| Albanell, J; Baselga, J; Bellmunt, J; Bermejo, B; Carulla, J; Eres, N; Gallardo, E; Ribas, A; Solé-Calvo, LA; Vera, R; Vidal, R | 1 |
| Bleyer, WA; Ingram, LC; Jardine, LF | 1 |
| Morland, BJ; Shaw, PJ | 1 |
| Gerster, JC | 1 |
| Cowan, BD; Isaacs, JD; McGehee, RP | 1 |
| Bertino, J; Casper, E; Christman, K; Colofiore, J; Kelsen, D; Martin, DS; Quan, V; Saltz, L; Schwartz, GK | 1 |
| Barisone, E; Brach Del Prever, A; Leone, L; Miniero, R; Ridolfi, L; Vivalda, M; Vivenza, C | 1 |
| Baume, D; Bladou, F; Camerlo, J; Coulange, C; Cowen, D; Gravis, G; Lechevallier, E; Maraninchi, D; Resbeut, M; Serment, G; Viens, P | 1 |
| Avanzini, P; Baldini, L; Cavanna, L; Colombi, M; Federico, M; Gobbi, P; Guffanti, A; Maiolo, AT; Pieresca, C; Silingardi, V | 1 |
| Baldini, E; Conte, P; da Prato, M; Evangelista, G; Giannessi, P; Lencioni, M; Meucci, C; Roncella, M; Spinelli, C; Tibaldi, C | 1 |
| Cooley, TP; Dezube, BJ; Herndier, B; Huang, J; Kaplan, LD; Levine, AM; Northfelt, DW; Straus, DJ; Testa, MA; Tulpule, A; Von Roenn, J | 1 |
| Bessho, F; Iga, T; Matsushita, Y; Moriwaki, K; Sawada, Y; Yamamoto, K | 1 |
| Edelman, MJ; Houston, J; Lauder, I; Meyers, FJ | 1 |
| Ayala, F; Casado, A; Diaz-Rubio, E; López-Martin, JA; Martin, M; Nieto, Y; Rodriguez-Lescure, A | 1 |
| Doi, R; Fujimoto, K; Hosotani, R; Imamura, M; Koshiba, T; Lee, JU; Miyamoto, Y; Wada, M | 1 |
| Fazeny, B; Fridrik, MA; Greil, R; Hausmaninger, H; Helm, W; Hudec, M; Klocker, J; Krieger, O; Neubauer, M; Oppitz, P; Pont, J; Radaszkiewicz, T; Simonitsch, I; Stöger, M | 1 |
| Abernethy, VE; Dawson, JK; Lynch, MP | 1 |
| Bigazzi, C; Bocchia, M; Forconi, F; Lauria, F; Marotta, G | 1 |
| Hietanen, P; Joensuu, H; Teerenhovi, L | 1 |
| Akaza, H; Kotake, T; Kubota, Y; Matsumura, Y; Miki, T; Togashi, M; Usami, M | 1 |
| Flombaum, CD; Meyers, PA | 1 |
| Ackland, S; Bishop, JF; Canetta, R; Dewar, J; Goldstein, D; Gurney, H; Kennedy, I; Levi, J; Olver, IN; Smith, J; Stephenson, J; Tattersall, MH; Toner, GC; Walpole, E | 1 |
| Ozbek, N; Tuncer, AM; Yetgin, S | 1 |
| Auclerc, MF; Auvrignon, A; Baruchel, A; Bauduer, F; Berthou, C; Bordigoni, P; Demeocq, F; Lamagnere, JP; Landman-Parker, J; Leblanc, T; Legall, E; Leverger, G; Mathey, C; Michel, G; Pautard, B; Perel, Y; Schaison, G; Schneider, P | 1 |
| Benz, MS; Kramer, D; Murray, TG; Scott, IU; Toledano, S | 1 |
| Chen, CM; Cheng, SH; Hsieh, CI; Huang, AT; Liu, MC; Liu, TW; Tsou, MH | 1 |
| Boot, H; Craanen, M; Gerritsen, WR; Swart, M; Taal, BG; Westermann, AM | 1 |
| Apostolidis, J; Foran, JM; Gupta, RK; Kelsey, SM; Lister, TA; Rohatiner, AZ; Shamash, J; Walewski, J; Wilson, AM | 1 |
| Aapro, MS; Alberto, P; Allal, AS; Berney, CR; Marti, MC; Morel, P; Rohner, S; Roth, AD | 1 |
| Arnoldi, E; Aschele, C; Barni, S; Bruzzi, P; Caroti, C; Cortesi, E; Frassineti, GL; Frontini, L; Gallo, L; Giuliani, R; Grossi, F; Guglielmi, A; Labianca, R; Lanfranco, C; Pessi, MA; Piazza, E; Ravaioli, A; Sobrero, A; Turci, D; Zaniboni, A | 1 |
| Weiss, M | 1 |
| Hamidou, M; Lamy, T | 1 |
| Bernard, M; Casassus, P; Delain, M; Desablens, B; Guilhot, F; Hunault-Berger, M; Ifrah, N; Jouet, JP; Milpied, N; Sadoun, A | 1 |
| Go, RS; Li, CY; Phyliky, RL; Tefferi, A | 1 |
| Abrahamova, J; Kocak, I; Kroslakova, D; Kubala, E; Machova, D; Malec, V; Pavlikova, E; Pavlikova, I; Prausova, J; Simova, E; Sirakova, I; Tuma, P; Van Praagh, I; Wagnerova, M | 1 |
| Barcos, M; Bloomfield, CD; Freter, CE; Frizzera, G; Johnson, JL; Lee, EJ; Peterson, BA; Petroni, GR; Schiffer, CA | 1 |
| Chilcote, RR; Kadin, ME; Kjeldsberg, C; Krailo, MD; Meadows, AT; Morse, M; Siegel, SE; Sposto, R; Steinherz, PG; Termuhlen, AM | 1 |
| Jantunen, E; Myllykangas-Luosujärvi, R; Purokivi, M | 1 |
| Baruchel, A; Bertozzi, AI; Boutard, P; Frappaz, D; Laplanche, A; Mechinaud, F; Michon, J; Nelken, B; Patte, C; Schmitt, C | 1 |
| Belpomme, D; Clendeninn, N; Domenge, C; Humblet, Y; Johnston, A; Kelly, C; Penning, C; Pivot, X; Ruxer, R; Schneider, M; Stern, J; Tortochaux, J; Wadler, S | 1 |
| Creagan, ET; Edmonson, JH; Kugler, JW; Levitt, R; Mailliard, JA; Nair, S; Okuno, SH; Suman, VJ | 1 |
| Imaizumi, I; Iwama, A; Kameyama, Y; Nakamura, H; Nakamura, K; Nishigaki, N; Yamasaki, M | 1 |
| Boardman, CH; Dowdy, SC; Hartmann, LC; Long, HJ; Podratz, KC; Wilson, TO | 1 |
| Jones, ES; Jones, JB; Lange, RD; Vodopick, H; Yang, TJ | 1 |
| Harding, B; MacLennan, IC | 1 |
| Culvenor, J; Harding, B; MacLennan, IC | 1 |
| Bielec, M; Czarnecki, C; Dziuk, E; Jedrzejczak, WW; Siekierzyński, M | 1 |
| Armata, J; Bogusllawska-Jaworska, J | 1 |
| MacLennan, CM | 1 |
| Festenstein, M; Kay, HE; MacLennan, IC; Smith, PG | 1 |
| Brandwein, J; Burkes, RL; Sawka, CA; Shepherd, FA; Sutton, DM; Warner, E | 1 |
| Ezeamuzie, IC; Njoku, AC | 1 |
| Ellman, MH; Telfer, MC; Turner, AF | 1 |
| Maiche, AG; Muhonen, T; Porkka, K | 1 |
| Barton, C; Bliss, JM; Bower, M; Coombes, RC; Ford, HT; Gazet, JC; Law, M; Stein, RC | 1 |
| Aldred, K; Feldman, M; Lee, E; Lee, M | 1 |
| Amadori, S; Gherlinzoni, F; Guglielmi, C; Mandelli, F; Mazza, P; Tura, S | 1 |
| Cole-Sinclair, MF; McArthur, GA; Van Der Weyden, MB | 1 |
| Alarcón-Segovia, D; Kraus, A | 1 |
| Mayall, B; Parkin, JD; Poggi, G | 1 |
| Guillemin, F; Pourel, J | 1 |
| Brecher, M; Crist, W; Harris, MB; Krance, RA; Land, VJ; Newman, EM; Pullen, J; Ravindranath, Y; Shuster, JJ; Wimmer, R | 1 |
| Yoshinari, N | 1 |
| Granger, DN; Keenan, CM; Wallace, JL | 1 |
| Foot, AB; Mott, MG; Oakhill, A | 1 |
| Ellman, MH; Ginsberg, D | 1 |
| Giesbrecht, E; Greenberg, M; Koren, G; Langevin, AM; Olivieri, N; Zipursky, A | 1 |
| Adelstein, DJ; Davis, BR; Hines, JD; Zakem, MH | 1 |
| Alton, K; Clarkson, B; Fain, K; Gabrilove, JL; Grous, J; Jakubowski, A; Moore, MA; Oettgen, HF; Scher, H; Souza, L; Sternberg, C; Welte, K; Wong, G; Yagoda, A | 1 |
| Clarkson, B; Fain, K; Gabrilove, JL; Grous, J; Jakubowski, A; Moore, MA; Scher, H; Sternberg, C; Wong, G; Yagoda, A | 1 |
| Aoyama, Y | 1 |
| Dolan, G; Lilleyman, JS; Richards, SM | 1 |
| Connolly, J; Gospodarowicz, M; Jewett, M; Tannock, I | 1 |
| Luthra, HS | 1 |
| Albo, V; Blatt, J; Orlando, S; Prin, W; Wollman, M | 1 |
| Fiechtner, JJ; Miller, DR; Starkebaum, G | 1 |
| Cousar, JB; Greco, FA; Greer, JP; Hainsworth, JD; Stein, RS; Wolff, SN | 1 |
| Anderson, J; Bloomfield, CD; Cooper, MR; Ginsberg, SJ; Gottlieb, AJ; Hurd, DD; Lachant, NA | 1 |
| Blackledge, GR; Child, JA; Ellis, IO; Fletcher, J; Jones, EL; Kavanagh, JA; Kelly, KA; O'Brien, CJ; Perren, TJ; Stuart, NS | 1 |
| Schrøder, H | 1 |
| Briese, V; Richter, C | 1 |
| Balis, FM; Bleyer, WA; Poplack, DG; Reaman, GH; Savitch, JL | 1 |
| Barton, JC; Egan, ML; Grossi, CE; Heck, LW; Koopman, WJ; Prasthofer, EF | 1 |
6 review(s) available for methotrexate and Neutropenia
| Article | Year |
|---|---|
Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials.
Topics: Anemia; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Leukopenia; Methotrexate; Neutropenia; Pancytopenia; Randomized Controlled Trials as Topic; Rheumatic Diseases; Severity of Illness Index; Thrombocytopenia; Vitamin B Complex | 2020 |
Pathophysiologic mechanisms and management of neutropenia associated with large granular lymphocytic leukemia.
Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Clinical Trials as Topic; Humans; Killer Cells, Natural; Leukemia, Large Granular Lymphocytic; Methotrexate; Neutropenia; T-Lymphocytes | 2011 |
Felty's syndrome without rheumatoid arthritis?
Topics: Adrenal Cortex Hormones; Agranulocytosis; Antirheumatic Agents; Arthritis, Rheumatoid; Felty Syndrome; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Splenomegaly | 2013 |
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Controlled Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Randomized Controlled Trials as Topic; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine | 2001 |
[Large granular lymphocyte proliferations. Clinical and pathogenic aspects].
Topics: Autoimmune Diseases; Blotting, Southern; Cyclophosphamide; Cytokines; fas Receptor; France; HTLV-I Infections; Humans; Immunophenotyping; Immunosuppressive Agents; Leukemia, Lymphoid; Methotrexate; Neutropenia; Polymerase Chain Reaction; Prognosis; Registries; Splenomegaly | 2001 |
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine | 2001 |
77 trial(s) available for methotrexate and Neutropenia
| Article | Year |
|---|---|
Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Diphosphonates; Doxorubicin; Etoposide; Female; France; Humans; Ifosfamide; Imidazoles; Kaplan-Meier Estimate; Male; Methotrexate; Neutropenia; Osteosarcoma; Young Adult; Zoledronic Acid | 2018 |
Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Nasopharyngitis; Neutropenia; Severity of Illness Index; Treatment Outcome | 2019 |
Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential methotrexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106).
Topics: Adult; Aged; Anorexia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasm Staging; Neutropenia; Odds Ratio; Peritoneal Neoplasms; Stomach Neoplasms; Treatment Outcome | 2013 |
A phase 1 dose escalation study of idarubicin combined with methotrexate, vindesine, and prednisolone for untreated elderly patients with primary central nervous system lymphoma. The GOELAMS LCP 99 trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Idarubicin; Immunocompetence; Infections; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Palliative Care; Prednisolone; Recurrence; Remission Induction; Renal Insufficiency; Thrombocytopenia; Treatment Outcome; Vindesine | 2014 |
Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998).
Topics: Aged; Aged, 80 and over; Anemia; Cyclophosphamide; Drug Monitoring; Female; Finland; Gene Expression Regulation, Leukemic; Humans; Immunosuppressive Agents; International Cooperation; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Middle Aged; Mutation; Neutropenia; STAT3 Transcription Factor; Survival Analysis; Transcriptome; United States | 2015 |
Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Interleukin-6 Receptor alpha Subunit; Male; Methotrexate; Middle Aged; Neutropenia; Treatment Outcome; Young Adult | 2015 |
Stem cell transplantation in severe congenital neutropenia: an analysis from the European Society for Blood and Marrow Transplantation.
Topics: Acute Disease; Adolescent; Adult; Allografts; Child; Child, Preschool; Cyclosporine; Europe; Female; Graft Rejection; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Incidence; Male; Methotrexate; Middle East; Neutropenia; Retrospective Studies; Societies, Medical; Unrelated Donors | 2015 |
Doubling the single-dose infusion rate of tocilizumab in rheumatoid arthritis is safe and efficacious.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Hypersensitivity; Edema; Fatigue; Female; Flushing; Glucocorticoids; Headache; Humans; Hypercholesterolemia; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Nasopharyngitis; Neutropenia; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Comparative Effectiveness Research; Cytarabine; Death, Sudden; Denmark; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Gastrointestinal Diseases; Germany; Heart Injuries; Hematopoietic Stem Cell Transplantation; Humans; Hyperglycemia; Induction Chemotherapy; Infections; Intraocular Lymphoma; Italy; Kaplan-Meier Estimate; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mucositis; Neurotoxicity Syndromes; Neutropenia; Optic Nerve Neoplasms; Poisoning; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Stroke; Switzerland; Thiotepa; Thrombocytopenia; Thrombosis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; United Kingdom | 2016 |
Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Headache; Humans; Infections; Injections; Male; Methotrexate; Middle Aged; Neutropenia; Remission Induction; Retreatment; Severity of Illness Index | 2017 |
A phase II study of sequential methotrexate and 5-fluorouracil chemotherapy in previously treated gastric cancer: a report from the Gastrointestinal Oncology Group of the Japan Clinical Oncology Group, JCOG 9207 trial.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drug Administration Schedule; Female; Fluorouracil; Humans; Injections, Intravenous; Japan; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Neutropenia; Stomach Neoplasms; Survival Analysis; Treatment Outcome; Vitamin B Complex | 2008 |
Low-dose capecitabine plus docetaxel as first-line therapy for metastatic breast cancer: phase II results.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Carcinoma; Cyclophosphamide; Deoxycytidine; Disease-Free Survival; Docetaxel; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Neutropenia; Paclitaxel; Peripheral Nervous System Diseases; Taxoids; Treatment Outcome | 2009 |
Activity and safety of combination chemotherapy with methotrexate, ifosfamide, l-asparaginase and dexamethasone (MILD) for refractory lymphoid malignancies: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Female; Hematologic Neoplasms; Humans; Ifosfamide; Lymphopenia; Male; Methotrexate; Middle Aged; Mucormycosis; Neutropenia; Pilot Projects | 2010 |
Use of pegfilgrastim support on day 9 to maintain relative dose intensity of chemotherapy in breast cancer patients receiving a day 1 and 8 CMF regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma; Chemotherapy, Adjuvant; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Filgrastim; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Neutropenia; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome | 2009 |
Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Methotrexate; Middle Aged; Neutropenia; Odds Ratio; Phenotype; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Southwestern United States; Superoxide Dismutase; Tamoxifen; Time Factors; Treatment Outcome | 2010 |
The AMBITION trial: tocilizumab monotherapy for rheumatoid arthritis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; C-Reactive Protein; Disease Progression; Double-Blind Method; Female; Humans; Infections; Male; Methotrexate; Middle Aged; Neutropenia; Receptors, Interleukin-6; Treatment Outcome | 2010 |
Pathological complete response rates following different neoadjuvant chemotherapy regimens for operable breast cancer according to ER status, in two parallel, randomized phase II trials with an adaptive study design (ECTO II).
Topics: Adult; Aged; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Humans; Leukopenia; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm, Residual; Neutropenia; Paclitaxel; Receptors, Estrogen; Treatment Outcome | 2012 |
Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; DNA, Viral; Epstein-Barr Virus Infections; Etoposide; Female; Herpesvirus 4, Human; Humans; Ifosfamide; Kaplan-Meier Estimate; Leukopenia; Lymphoma, Extranodal NK-T-Cell; Male; Methotrexate; Middle Aged; Nasal Mucosa; Neutropenia; Prognosis; Prospective Studies; Steroids; Treatment Outcome; Young Adult | 2012 |
Association between radiotherapy vs no radiotherapy based on early response to VAMP chemotherapy and survival among children with favorable-risk Hodgkin lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Doxorubicin; Female; Hodgkin Disease; Humans; Male; Methotrexate; Nausea; Neuralgia; Neutropenia; Prednisone; Treatment Outcome; Vinblastine; Vomiting; Young Adult | 2012 |
Brief intensive therapy for older adults with newly diagnosed Burkitt or atypical Burkitt lymphoma/leukemia.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Humans; Injections, Spinal; Kaplan-Meier Estimate; Leukemia; Male; Methotrexate; Middle Aged; Mucositis; Neutropenia; Prednisone; Remission Induction; Rituximab; Time Factors; Treatment Outcome; Vincristine | 2013 |
Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Arthritis, Juvenile; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infections; Male; Methotrexate; Neutropenia; Receptors, Interleukin-6; Transaminases | 2012 |
Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Juvenile; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infections; Interleukin-1beta; Kaplan-Meier Estimate; Macrophage Activation Syndrome; Male; Methotrexate; Neutropenia; Thrombocytopenia | 2012 |
Feasibility trial of methotrexate-paclitaxel as a second line therapy in advanced urothelial cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Drug Administration Schedule; Female; Humans; Kidney Neoplasms; Male; Methotrexate; Middle Aged; Neutropenia; Paclitaxel; Palliative Care; Peripheral Nervous System Diseases; Survival Analysis; Treatment Outcome; Urinary Bladder Neoplasms | 2002 |
Docetaxel and cisplatin with granulocyte colony-stimulating factor (G-CSF) versus MVAC with G-CSF in advanced urothelial carcinoma: a multicenter, randomized, phase III study from the Hellenic Cooperative Oncology Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease Progression; Docetaxel; Doxorubicin; Female; Granulocyte Colony-Stimulating Factor; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Prognosis; Taxoids; Thrombocytopenia; Treatment Outcome; Urologic Neoplasms; Vinblastine | 2004 |
Platinum-free combination chemotherapy in patients with advanced or metastatic transitional cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Deoxycytidine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Neutropenia; Paclitaxel; Urologic Neoplasms | 2004 |
The outcome of elderly patients with advanced urothelial carcinoma after platinum-based combination chemotherapy.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Cisplatin; Deoxycytidine; Docetaxel; Doxorubicin; Female; Follow-Up Studies; Gemcitabine; Humans; Infections; Male; Methotrexate; Middle Aged; Neutropenia; Prognosis; Survival Analysis; Taxoids; Treatment Outcome; Urinary Bladder Neoplasms; Vinblastine | 2005 |
Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Female; Gene Amplification; Genes, erbB-2; Humans; Immunization, Passive; Leukopenia; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Methotrexate; Middle Aged; Neoplasm Proteins; Neutropenia; Receptor, ErbB-2; Remission Induction; Trastuzumab; Treatment Outcome; Ventricular Dysfunction, Left | 2006 |
Analysis of efficacy and toxicity of chemotherapy with cisplatin, 5-fluorouracil, methotrexate and leucovorin (PFML) and radiotherapy in the treatment of locally advanced squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Mucositis; Neutropenia; Radiotherapy Dosage | 2007 |
Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Severity of Illness Index; Survival Analysis; Teniposide; Treatment Outcome; Vincristine | 2007 |
Treatment of patients with metastatic osteogenic sarcoma: a report from the Children's Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Kidney Diseases; Leucovorin; Male; Methotrexate; Neoplasm Metastasis; Neutropenia; Osteosarcoma; Thrombocytopenia; Time Factors; Vincristine | 1984 |
Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B.
Topics: Adult; Antibiotics, Antineoplastic; Asparaginase; B-Lymphocytes; Brain Neoplasms; Clinical Trials as Topic; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Naphthacenes; Neutropenia; Prednisone; Prognosis; Prospective Studies; Random Allocation; T-Lymphocytes; Thrombocytopenia; Vincristine | 1984 |
Use of methotrexate and 5-FU for recurrent head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Diarrhea; Drug Therapy, Combination; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Infections; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neutropenia | 1982 |
Role of intravenous hyperalimentation as an adjunct to intensive chemotherapy for small cell bronchogenic carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bone Marrow; Carcinoma, Bronchogenic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Gastrointestinal Diseases; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neutropenia; Parenteral Nutrition; Procarbazine; Vincristine | 1981 |
Autologous bone marrow transplantation in poor-risk high-grade non-Hodgkin's lymphoma in first complete remission. Newcastle and Northern Lymphoma Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Blood Platelets; Bone Marrow Transplantation; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylprednisolone; Middle Aged; Neutropenia; Neutrophils; Platelet Count; Prednisolone; Retrospective Studies; Risk Factors; Vincristine; Vindesine | 1994 |
The use of G-CSF or GM-CSF mobilized peripheral blood progenitor cells (PBPC) alone or to augment marrow as hematologic support of single or multiple cycle high-dose chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Marrow Transplantation; Breast Neoplasms; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Graft Survival; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leukapheresis; Male; Melphalan; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Salvage Therapy; Treatment Outcome | 1993 |
Combined chemotherapy and granulocyte colony-stimulating factor (G-CSF) mobilise large numbers of peripheral blood progenitor cells in pretreated patients.
Topics: Adult; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Dexamethasone; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leukapheresis; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Salvage Therapy; Treatment Outcome | 1994 |
Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Infection Control; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome | 1995 |
Phase I trial of m-BACOD and granulocyte macrophage colony stimulating factor in HIV-associated non-Hodgkin's lymphoma.
Topics: Adult; AIDS-Related Opportunistic Infections; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dexamethasone; Doxorubicin; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Core Protein p24; Humans; Kidney; Leucovorin; Leukocyte Count; Lung; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Remission Induction; Vincristine | 1993 |
Four-step high-dose sequential chemotherapy with double hematopoietic progenitor-cell rescue for metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Feasibility Studies; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Melphalan; Methotrexate; Middle Aged; Mitoxantrone; Neoplasm Metastasis; Neutropenia; Remission Induction; Thrombocytopenia; Vincristine | 1995 |
Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French Registry on autologous transplantation in multiple myeloma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Blood Proteins; Bone Marrow; Bone Marrow Transplantation; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Life Tables; Male; Methotrexate; Middle Aged; Multiple Myeloma; Myeloma Proteins; Neutropenia; Remission Induction; Risk Factors; Salvage Therapy; Survival Analysis; Treatment Outcome; Whole-Body Irradiation | 1995 |
A pharmacologically guided phase I study of carboplatin in combination with methotrexate and vinblastine in advanced urothelial cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Transitional Cell; Cell Count; Edetic Acid; Female; Glomerular Filtration Rate; Humans; Infusions, Intravenous; Kidney Neoplasms; Linear Models; Male; Methotrexate; Middle Aged; Neutropenia; Neutrophils; Thrombocytopenia; Ultrafiltration; Ureteral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Vinblastine | 1995 |
[M-VAC chemotherapy for advanced urothelial cancer--side effects and their management].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Colony-Stimulating Factors; Doxorubicin; Female; Gastrointestinal Diseases; Granisetron; Humans; Kidney Neoplasms; Kidney Pelvis; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neutropenia; Recombinant Proteins; Ureteral Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms; Vinblastine | 1994 |
Short-term administration of granulocyte-macrophage colony stimulating factor decreases hematopoietic toxicity of cytostatic drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Humans; Methotrexate; Middle Aged; Neutropenia; Thrombocytopenia | 1993 |
Carboplatin in combination as first-line therapy in advanced breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neutropenia; Thrombocytopenia | 1993 |
A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Berlin-Frankfurt-Münster Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Fever; Filgrastim; Gastrointestinal Diseases; Germany; Granulocyte Colony-Stimulating Factor; Hematologic Diseases; Humans; Ifosfamide; Infant; Infection Control; Life Tables; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Recombinant Proteins; Risk; Survival Analysis; Thioguanine; Vincristine; Vindesine | 1996 |
Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine | 1996 |
Five-day course of granulocyte colony-stimulating factor in patients with prolonged neutropenia after adjuvant chemotherapy for breast cancer is a safe and cost-effective schedule to maintain dose-intensity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Breast Neoplasms, Male; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Leukocyte Count; Male; Methotrexate; Middle Aged; Neutropenia; Safety | 1996 |
A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Uridine | 1996 |
Growth factor allows effective dose-intensive regimen in advanced breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Neutropenia; Survival Analysis; Treatment Outcome | 1995 |
Impact of recombinant human granulocyte colony stimulating factor on dose intensity and toxicity of three cycles of methotrexate, vinblastine, doxorubicin and cisplatin in patients with previously untreated urothelial bladder carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Combined Modality Therapy; Cystectomy; Doxorubicin; Female; Granulocyte Colony-Stimulating Factor; Humans; Infections; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Neutropenia; Recombinant Proteins; Stomatitis; Thrombocytopenia; Urinary Bladder Neoplasms; Vinblastine | 1996 |
Filgrastim and lack of support of intensive adjuvant chemotherapy for high-risk breast cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Epirubicin; Female; Filgrastim; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Leukocyte Count; Methotrexate; Middle Aged; Neutropenia; Recombinant Proteins; Survival Rate; Vincristine | 1997 |
Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; CD4 Lymphocyte Count; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Infections; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Survival Analysis; Thrombocytopenia; Vincristine | 1997 |
Phase I trial of paclitaxel, carboplatin, and methotrexate with granulocyte colony-stimulating factor and leucovorin in advanced transitional cell carcinoma.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Carcinoma, Transitional Cell; Confidence Intervals; Disease Progression; Drug Administration Schedule; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Nervous System Diseases; Neutropenia; Paclitaxel; Remission Induction; Salvage Therapy; Sepsis; Urinary Bladder Neoplasms | 1997 |
Randomized open label phase III trial of CEOP/IMVP-Dexa alternating chemotherapy and filgrastim versus CEOP/IMVP-Dexa alternating chemotherapy for aggressive non-Hodgkin's lymphoma (NHL). A multicenter trial by the Austrian Working Group for Medical Tumor
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dexamethasone; Disease-Free Survival; Epirubicin; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Lymphocyte Count; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neutropenia; Prednisolone; Recombinant Proteins; Vincristine | 1997 |
Effect of recombinant human granulocyte colony stimulating factor (lenograstim) on chemotherapy induced neutropenia in patients with urothelial cancer.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cisplatin; Doxorubicin; Female; Fever; Granulocyte Colony-Stimulating Factor; Humans; Incidence; Lenograstim; Leukocyte Count; Male; Methotrexate; Middle Aged; Neutropenia; Neutrophils; Recombinant Proteins; Stomatitis; Survival Analysis; Urinary Bladder Neoplasms; Urothelium; Vinblastine | 1999 |
Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neutropenia; Paclitaxel; Prednisone; Quality of Life | 1999 |
Effects of G-CSF and high-dose methylprednisolone on peripheral stem cells, serum IL-3 levels and hematological parameters in acute lymphoblastic leukemia patients with neutropenia: a pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Etoposide; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Interleukin-3; Methotrexate; Methylprednisolone; Neutropenia; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2000 |
Use of recombinant human granulocyte colony-stimulating factor to increase chemotherapy dose-intensity: a randomized trial in very high-risk childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Infant; Infant, Newborn; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recombinant Proteins; Thrombocytopenia; Treatment Outcome; Vincristine | 2000 |
Adjuvant sequential chemotherapy with doxorubicin plus cyclophosphamide, methotrexate, and fluorouracil (ACMF) with concurrent radiotherapy in resectable advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Fluorouracil; Humans; Mastectomy, Modified Radical; Methotrexate; Middle Aged; Neutropenia | 2000 |
Sequence-dependent toxicity profile in modified FAMTX (fluorouracil-adriamycin-methotrexate) chemotherapy with lenograstim support for advanced gastric cancer: a feasibility study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cardia; Doxorubicin; Drug Administration Schedule; Esophagogastric Junction; Feasibility Studies; Female; Fluorouracil; Granulocyte Colony-Stimulating Factor; Humans; Lenograstim; Male; Methotrexate; Middle Aged; Neutropenia; Recombinant Proteins; Stomach Neoplasms | 2000 |
Low-dose continuous chemotherapy (LBCMVD-56) for refractory and relapsing lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Dexamethasone; Drug Administration Schedule; Female; Hodgkin Disease; Hospitalization; Humans; Infusions, Intravenous; Injections, Subcutaneous; Lomustine; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Sepsis; Treatment Outcome; Vincristine | 2000 |
Intra-arterial chemotherapy in locally advanced or recurrent carcinomas of the penis and anal canal: an active treatment modality with curative potential.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Anus Neoplasms; Arteries; Bleomycin; Cisplatin; Fluorouracil; Follow-Up Studies; Humans; Injections; Male; Methotrexate; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Neutropenia; Penile Neoplasms; Skin Diseases; Treatment Outcome | 2000 |
Schedule specific biochemical modulation of 5-fluorouracil in advanced colorectal cancer: a randomized study. GISCAD, IOR and collaborating centers.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Conjunctivitis; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Life Tables; Male; Methotrexate; Middle Aged; Neutropenia; Patient Compliance; Quality of Life; Salvage Therapy; Survival Analysis; Treatment Outcome | 2000 |
Daunorubicin continuous infusion induces more toxicity than bolus infusion in acute lymphoblastic leukemia induction regimen: a randomized study.
Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Female; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Infusions, Intravenous; Injections, Intravenous; Life Tables; Male; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Thrombocytopenia; Treatment Outcome; Vincristine | 2001 |
Vinorelbine, epirubicin, and methotrexate (VEM) as primary treatment in locally advanced breast cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Epirubicin; Female; Humans; Mastectomy; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neutropenia; Survival Rate; Treatment Outcome; Vinblastine; Vinorelbine | 2001 |
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine | 2001 |
Comparison of long-term outcome of children and adolescents with disseminated non-lymphoblastic non-Hodgkin lymphoma treated with COMP or daunomycin-COMP: A report from the Children's Cancer Group.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Heart Diseases; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Prednisone; Recurrence; Stomatitis; Survival Analysis; Thrombocytopenia; Treatment Outcome; Vincristine | 2001 |
Granulocyte colony-stimulating factor in induction treatment of children with non-Hodgkin's lymphoma: a randomized study of the French Society of Pediatric Oncology.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Female; Granulocyte Colony-Stimulating Factor; Hospitalization; Humans; Infections; Lymphoma, Non-Hodgkin; Male; Methotrexate; Morbidity; Neutropenia; Prednisone; Stomatitis; Vincristine | 2002 |
Result of two randomized trials comparing nolatrexed (Thymitaq) versus methotrexate in patients with recurrent head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Diarrhea; Enzyme Inhibitors; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Quinazolines; Thymidylate Synthase; Treatment Outcome | 2001 |
Phase II study of methotrexate, vinblastine, doxorubicin, and cisplatin in patients with squamous cell carcinoma of the upper respiratory or alimentary passages of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Disease Progression; Disease-Free Survival; Doxorubicin; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Respiratory Tract Neoplasms; Survival Rate; Treatment Outcome; Vinblastine | 2002 |
Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy.
Topics: Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Neutropenia; Neutrophils; Remission, Spontaneous; Time Factors | 1976 |
Analysis of treatment in childhood leukaemia. I. Predisposition to methotrexate-induced neutropenia after craniospinal irradiation. Report to the Medical Research Council of the Working Party on Leukaemia in Childhood.
Topics: Agranulocytosis; Central Nervous System; Child; Child, Preschool; Clinical Trials as Topic; Cytarabine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphocytes; Mercaptopurine; Methotrexate; Neutropenia; Prednisolone; Radiation Effects; Radiotherapy Dosage; Remission, Spontaneous; Time Factors; Vincristine | 1975 |
Treatment of AIDS-related non-Hodgkin's lymphoma with a twelve week chemotherapy program.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Bleomycin; Cyclophosphamide; Doxorubicin; Feasibility Studies; Female; Humans; Incidence; Leucovorin; Life Tables; Lymphoma, AIDS-Related; Male; Methotrexate; Middle Aged; Neutropenia; Pentamidine; Pneumonia, Pneumocystis; Prednisone; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine | 1992 |
Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Methotrexate; Middle Aged; Mitomycin; Mitoxantrone; Neutropenia | 1992 |
Phase III comparative trial (m-BACOD v m-BNCOD) in the treatment of stage II to IV non-Hodgkin's lymphomas with intermediate- or high-grade histology.
Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leucovorin; Leukopenia; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mitoxantrone; Mouth Mucosa; Neoplasm Staging; Neutropenia; Recurrence; Remission Induction; Stomatitis; Stroke Volume; Survival Rate; Vincristine | 1990 |
A pilot study of intermediate-dose methotrexate and cytosine arabinoside, "spread-out" or "up-front," in continuation therapy for childhood non-T, non-B acute lymphoblastic leukemia. A Pediatric Oncology Group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Fever; Humans; Infant; Infections; Length of Stay; Leukocyte Count; Male; Methotrexate; Neutropenia; Pilot Projects; Platelet Count; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate | 1991 |
Prognostic importance of myelosuppression during maintenance treatment of lymphoblastic leukaemia. Leukaemia in Childhood Working Party of the Medical Research Council.
Topics: Adolescent; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutropenia; Prognosis; Randomized Controlled Trials as Topic; Survival Rate; United Kingdom | 1989 |
138 other study(ies) available for methotrexate and Neutropenia
| Article | Year |
|---|---|
Acute respiratory distress syndrome precipitated by granulocyte colony-stimulating factor in undiagnosed
Topics: Granulocyte Colony-Stimulating Factor; Humans; Leflunomide; Male; Methotrexate; Middle Aged; Neutropenia; Pneumonia, Pneumocystis; Respiratory Distress Syndrome | 2022 |
Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis.
Topics: Antioxidants; Humans; Hydrolyzable Tannins; Ligands; Macrophages; Mannose; Methotrexate; Molecular Docking Simulation; Molecular Dynamics Simulation; Neutropenia; Polyphenols | 2022 |
Long-term safety and efficacy of sarilumab with or without background csDMARDs in rheumatoid arthritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Neutropenia; Treatment Outcome | 2023 |
Prophylactic piperacillin administration in pediatric patients with solid tumors following different intensities of chemotherapy.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Child; Child, Preschool; Drug Resistance, Microbial; Female; Fever; Fluorouracil; Humans; Infant; Leucovorin; Male; Methotrexate; Neuroblastoma; Neutropenia; Piperacillin; Retrospective Studies | 2020 |
Incidence, Clinical Features, and Outcomes of Late-Onset Neutropenia From Rituximab for Autoimmune Disease.
Topics: Adult; Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Asymptomatic Diseases; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Fever; Filgrastim; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Hematologic Agents; Humans; Immunologic Factors; Incidence; Lupus Erythematosus, Systemic; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Nephrosis, Lipoid; Neutropenia; Proportional Hazards Models; Recurrence; Retrospective Studies; Risk Factors; Rituximab; Sepsis | 2021 |
Machine learning to predict high-dose methotrexate-related neutropenia and fever in children with B-cell acute lymphoblastic leukemia.
Topics: Artificial Intelligence; B-Lymphocytes; Child; Humans; Machine Learning; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Biologic Disease-modifying Antirheumatic Drug (bDMARD)-induced Neutropenia: A Registry from a Retrospective Cohort of Patients with Rheumatic Diseases Treated with 3 Classes of Intravenous bDMARD.
Topics: Abatacept; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Biological Products; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Neutropenia; Registries; Retrospective Studies; Rheumatic Diseases | 2017 |
Ambulatory High-dose Methotrexate Administration in Pediatric Osteosarcoma Patients at a Single Institution in Argentina.
Topics: Adolescent; Algorithms; Ambulatory Care; Anemia; Antacids; Argentina; Chemical and Drug Induced Liver Injury; Child; Diarrhea; Female; Humans; Hydrogen-Ion Concentration; Leucovorin; Leukopenia; Male; Methotrexate; Mucositis; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia; Vomiting | 2017 |
A review of sarilumab for the treatment of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Neutropenia; Receptors, Interleukin-6 | 2018 |
Erythroderma and extensive poikiloderma - a rare initial presentation of dermatomyositis: a case report.
Topics: Dermatologic Agents; Dermatomyositis; Electromyography; Female; Fever; Humans; Methotrexate; Middle Aged; Muscle Weakness; Neutropenia; Prednisolone; Skin Abnormalities; Treatment Outcome | 2018 |
Factors that Predict Neutropenia in Korean Patients with Advanced Urothelial Cancer after Cisplatin- Based Systemic Chemotherapy.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Deoxycytidine; Doxorubicin; Gemcitabine; Humans; Leukocyte Count; Methotrexate; Middle Aged; Neutropenia; Neutrophils; Republic of Korea; Risk Factors; Urologic Neoplasms; Vinblastine | 2018 |
Transaminitis and neutropenia are rare in patients on methotrexate: evidence from a large cohort of inflammatory arthritis patients.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Methotrexate; Neutropenia; Transaminases | 2019 |
Experience with ambulatory high-dose methotrexate administration as CNS prophylaxis in patients with non-Hodgkin lymphoma.
Topics: Adult; Aged; Ambulatory Care Facilities; Diarrhea; Female; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Prospective Studies; Sodium Bicarbonate; Vomiting; Young Adult | 2020 |
Treatment of Combined Autoimmune Neutropenia and Immune Thrombocytopenia with Methotrexate.
Topics: Adult; Antimetabolites, Antineoplastic; Autoantibodies; Autoimmune Diseases; Humans; Male; Methotrexate; Neutropenia; Neutrophils; Platelet Count; Thrombocytopenia | 2020 |
Fluoropyrimidine with or without platinum as first-line chemotherapy in patients with advanced gastric cancer and severe peritoneal metastasis: a multicenter retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Ascites; Cisplatin; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Malnutrition; Methotrexate; Middle Aged; Neutropenia; Organoplatinum Compounds; Oxonic Acid; Peritoneal Neoplasms; Progression-Free Survival; Pyridines; Retrospective Studies; Stomach Neoplasms; Tegafur; Treatment Outcome; Withholding Treatment; Young Adult | 2019 |
Long-term safety of sarilumab in rheumatoid arthritis: an integrated analysis with up to 7 years' follow-up.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Erythema; Female; Follow-Up Studies; Humans; Incidence; Male; Methotrexate; Middle Aged; Neutropenia; Respiratory Tract Infections; Treatment Outcome | 2020 |
Temozolomide as a Single Agent Maintenance Therapy in Elderly Patients With Primary CNS Lymphoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Drug Therapy, Combination; Female; Humans; Lymphoma, Non-Hodgkin; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Neutropenia; Procarbazine; Progression-Free Survival; Rituximab; Temozolomide; Vincristine | 2019 |
Efficacy and safety of tocilizumab in a real-life observational cohort of patients with polyarticular juvenile idiopathic arthritis.
Topics: Adolescent; Alanine Transaminase; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Leflunomide; Male; Medication Adherence; Methotrexate; Neutropenia; Prednisolone; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2020 |
Two cases of severe neutropenia in patients on low-dose methotrexate and ceftriaxone.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Infectious; Arthritis, Psoriatic; Ceftriaxone; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neutropenia; Propionibacterium acnes; Staphylococcus aureus | 2019 |
Do impaired memory, cognitive dysfunction and distress play a role in methotrexate-related neutropenia in rheumatoid arthritis patients? A comparative study.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cognition Disorders; Female; Humans; Male; Memory Disorders; Methotrexate; Middle Aged; Neutropenia; Stress, Psychological | 2013 |
Safety and efficacy of low-dose methotrexate for pediatric patients with steroid-refractory acute graft-versus-host disease after hematopoietic stem cell transplantation.
Topics: Adolescent; Child; Child, Preschool; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Injections, Intravenous; Male; Methotrexate; Neutropenia; Retrospective Studies; Steroids; Treatment Outcome | 2014 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase | 2014 |
Long-term efficacy and safety outcomes of modified (simplified) MVAC (methotrexate/vinblastine/doxorubicin/cisplatin) as frontline therapy for unresectable or metastatic urothelial cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Disease-Free Survival; Doxorubicin; Humans; Methotrexate; Middle Aged; Neutropenia; Treatment Outcome; Urinary Bladder Neoplasms; Vinblastine | 2014 |
Clinical outcomes of patients with newly diagnosed primary central nervous system lymphoma are comparable on treatment with high-dose methotrexate plus temozolomide and with high-dose methotrexate plus cytarabine: a single-institution experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neutropenia; Remission Induction; Temozolomide; Thrombocytopenia; Treatment Outcome; Young Adult | 2014 |
[Large granular lymphocytic leukemia. A rare disease with personalized treatment options].
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Cyclosporine; Female; Humans; Immunophenotyping; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Middle Aged; Molecular Targeted Therapy; Neutropenia; Precision Medicine; Rare Diseases; Retrospective Studies; Sepsis; Treatment Outcome | 2014 |
Report of 6 cases of large granular lymphocytic leukemia and plasma cell dyscrasia.
Topics: Aged; Aged, 80 and over; Anemia; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Causality; Cladribine; Combined Modality Therapy; Cyclophosphamide; Disease Progression; Female; Humans; Lenalidomide; Leukemia, Large Granular Lymphocytic; Male; Melphalan; Methotrexate; Middle Aged; Multiple Myeloma; Neutropenia; Paraproteinemias; Peripheral Blood Stem Cell Transplantation; Prednisone; Protease Inhibitors; Pyrazines; Registries; Retrospective Studies; Thalidomide | 2014 |
Successful treatment with allogenic hematopoietic stem cell transplantation of a severe congenital neutropenia patient harboring a novel ELANE mutation.
Topics: Allografts; Congenital Bone Marrow Failure Syndromes; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Leukocyte Elastase; Male; Methotrexate; Mutation, Missense; Neutropenia; Tacrolimus; Transplantation Conditioning; Treatment Outcome | 2014 |
Cyclophosphamide, hydroxyurea, actinomycin D, methotrexate, and vincristine in the treatment of gestational trophoblastic neoplasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dactinomycin; Female; Gestational Trophoblastic Disease; Humans; Hydroxyurea; Methotrexate; Neoplasm Recurrence, Local; Neutropenia; Pregnancy; Retrospective Studies; Salvage Therapy; Stomatitis; Survival Rate; Treatment Outcome; Vincristine; Vomiting | 2015 |
Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Thrombocytopenia | 2015 |
Comparative effectiveness of tocilizumab with either methotrexate or leflunomide in the treatment of rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Neutropenia; Retrospective Studies; Treatment Outcome | 2015 |
Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Folic Acid; Hematologic Diseases; Humans; Hypoalbuminemia; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Retrospective Studies; Rheumatic Diseases; Risk Factors; Serum Albumin | 2016 |
Combination chemotherapy with methotrexate and vinblastine for surgically unresectable, aggressive fibromatosis.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Disease-Free Survival; Female; Fever; Fibromatosis, Aggressive; Humans; Kaplan-Meier Estimate; Liver; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Retrospective Studies; Transaminases; Treatment Outcome; Vinblastine; Young Adult | 2016 |
Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; Female; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Thrombocytopenia | 2008 |
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Dasatinib; Daunorubicin; Granulocyte Colony-Stimulating Factor; Humans; In Situ Hybridization, Fluorescence; Male; Methotrexate; Mitoxantrone; Neoplasm Proteins; Neutropenia; Oncogene Proteins, Fusion; Peripheral Blood Stem Cell Transplantation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Remission Induction; Splenic Rupture; Thiazoles; Vincristine; Young Adult | 2009 |
Prolonged accumulation of high-dose methotrexate in a case with large liver cysts.
Topics: Anorexia; Antimetabolites, Antineoplastic; Burkitt Lymphoma; Cysts; Diarrhea; Dose-Response Relationship, Drug; Humans; Liver; Male; Methotrexate; Middle Aged; Neutropenia; Time Factors; Tissue Distribution | 2009 |
Malnutrition and neutropenia in children treated for Burkitt lymphoma in Malawi.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Comorbidity; Drug Administration Schedule; Female; Humans; Hydrocortisone; Incidence; Injections, Intravenous; Malawi; Male; Malnutrition; Methotrexate; Neutropenia; Prospective Studies; Survival Rate; Treatment Outcome; Vidarabine | 2009 |
Chemotherapy: Adjuvant chemotherapy in older patients with breast cancer.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cyclophosphamide; Deoxycytidine; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Drug Therapy; Female; Fluorouracil; Humans; Meta-Analysis as Topic; Methotrexate; Neoplasm Recurrence, Local; Neutropenia; Patient Compliance; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Estrogen; Survival Analysis; Therapeutic Equivalency | 2009 |
Lack of association between elevated mean red cell volume and haematological toxicity in patients receiving long-term methotrexate for rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Erythrocyte Volume; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Prospective Studies; Retrospective Studies; Time Factors; Young Adult | 2010 |
Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Central Nervous System Neoplasms; Drug Administration Schedule; Female; Fever; Fungemia; Humans; Immunocompromised Host; Immunosuppressive Agents; Lupus Nephritis; Lymphoma; Methotrexate; Mycophenolic Acid; Neurotoxicity Syndromes; Neutropenia; Rituximab; Treatment Outcome; Young Adult | 2011 |
How I treat LGL leukemia.
Topics: Anemia; Arthritis, Rheumatoid; Cyclosporine; Humans; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Methotrexate; Neutropenia | 2011 |
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Child; Child, Preschool; China; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Logistic Models; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Skin Diseases; Thrombocytopenia | 2011 |
[Acute toxicity by methotrexate used for abortion purpose. Case report].
Topics: Abortifacient Agents; Abortion, Induced; Abortion, Missed; Abortion, Septic; Administration, Intravaginal; Adolescent; Anti-Bacterial Agents; Antidotes; Candidiasis, Oral; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Injections, Intramuscular; Leucovorin; Methotrexate; Misoprostol; Neutropenia; Poisoning; Pregnancy; Recombinant Proteins; Vomiting | 2011 |
Bone marrow gold.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Female; Gold Sodium Thiomalate; Humans; Methotrexate; Middle Aged; Neutropenia | 2012 |
Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country.
Topics: Antimetabolites, Antineoplastic; Cancer Care Facilities; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leucovorin; Male; Methotrexate; Mucositis; Neutropenia; Patient Readmission; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2012 |
Life-threatening complications following multidose methotrexate for medical management of ectopic pregnancy.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Therapeutic; Adult; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Medical Errors; Methotrexate; Neutropenia; Pregnancy; Pregnancy, Ectopic; Recombinant Proteins; Respiration, Artificial; Sepsis; Shock; Thrombocytopenia; Vitamin B Complex | 2012 |
Efficacy of a dose-intensified CHOP (Double-CHOP) regimen for peripheral T-cell lymphomas.
Topics: Adolescent; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Lymphoma, T-Cell, Peripheral; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Retrospective Studies; Risk Factors; Stem Cell Transplantation; Survival Rate; Thrombocytopenia; Transplantation, Autologous; Vincristine; Young Adult | 2013 |
Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis.
Topics: Adult; Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Chi-Square Distribution; Communicable Diseases; Cyclophosphamide; Female; Hospitals, University; Humans; Immunocompromised Host; Immunosuppressive Agents; Kaplan-Meier Estimate; Linear Models; Lymphocyte Count; Lymphopenia; Male; Methotrexate; Methylprednisolone; Middle Aged; Multivariate Analysis; Neutropenia; Plasmapheresis; Quebec; Retrospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2013 |
Clonal T-LGL population mimicking leukemia in Felty's syndrome--part of a continuous spectrum of T-LGL proliferations?
Topics: Adult; Aged; Arthralgia; Arthritis, Rheumatoid; Bone Marrow; Diagnosis, Differential; Exons; Felty Syndrome; Female; Gene Rearrangement, T-Lymphocyte; Humans; Immunophenotyping; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Sjogren's Syndrome; Splenomegaly; STAT3 Transcription Factor; T-Lymphocyte Subsets | 2013 |
Efficacy of a primary chemotherapy regimen combining vinorelbine, epirubicin, and methotrexate (VEM) as neoadjuvant treatment in 89 patients with operable breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Epirubicin; Female; Humans; Mastectomy; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neutropenia; Treatment Outcome; Vinblastine; Vinorelbine | 2002 |
Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience.
Topics: Antirheumatic Agents; Arthritis, Infectious; Azathioprine; Drug Monitoring; Humans; Hypokalemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Pancytopenia; Pneumonia; Product Surveillance, Postmarketing; Prostatic Neoplasms; Sepsis; Sulfasalazine; United Kingdom | 2002 |
Pasteurella multocida infection in a post-chemotherapy neutropenic host following cat exposure.
Topics: Aged; Animals; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cat Diseases; Cats; Ciprofloxacin; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Neutropenia; Pasteurella Infections; Pasteurella multocida | 2002 |
Salvage treatment with etoposide (VP-16), ifosfamide and cytarabine (Ara-C) for patients with recurrent primary central nervous system lymphoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Child, Preschool; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Evaluation; Etoposide; Female; Humans; Ifosfamide; Life Tables; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Analysis; Thrombocytopenia; Vincristine | 2003 |
Primary Sjögren's syndrome associated agranulocytosis: a benign disorder?
Topics: Adult; Aged; Agranulocytosis; Antibodies, Antinuclear; Antirheumatic Agents; Bone Marrow Examination; Female; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Neutropenia; Pregnancy; Sjogren's Syndrome; Steroids; Treatment Outcome | 2003 |
Methotrexate and bone marrow suppression: drug errors may be implicated in death.
Topics: Antirheumatic Agents; Death, Sudden; Drug Administration Schedule; Humans; Medication Errors; Methotrexate; Neutropenia | 2003 |
Tuboovarian abscess caused by Candida glabrata in a febrile neutropenic patient.
Topics: Abscess; Adult; Amphotericin B; Antifungal Agents; Antimetabolites, Antineoplastic; Candida glabrata; Candidiasis; Diagnosis, Differential; Fallopian Tubes; Female; Fever; Fluconazole; Genital Diseases, Female; Granulocyte Colony-Stimulating Factor; Humans; Hydatidiform Mole; Magnetic Resonance Imaging; Methotrexate; Neutropenia; Pregnancy | 2003 |
Moderate neutropenia with adjuvant CMF confers improved survival in early breast cancer.
Topics: Adult; Age of Onset; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Follow-Up Studies; Humans; Methotrexate; Middle Aged; Neutropenia; Prognosis; Survival Analysis | 2003 |
Neutropenia associated with the use of low-dose methotrexate in a peritoneal dialysis patient.
Topics: Aspergillosis; Dermatologic Agents; Fatal Outcome; Humans; Lung Diseases, Fungal; Male; Methotrexate; Middle Aged; Neutropenia; Opportunistic Infections; Peritoneal Dialysis, Continuous Ambulatory; Tomography, X-Ray Computed | 2004 |
Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.
Topics: Adenocarcinoma; Anilides; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Fatal Outcome; Goserelin; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplasms, Second Primary; Neutropenia; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostate-Specific Antigen; Prostatic Neoplasms; Recurrence; Sepsis; Tosyl Compounds; Vincristine | 2004 |
[Clinical study of modified M-VAC therapy with one 21-day cycle for advanced urothelial cancer].
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neutropenia; Thrombocytopenia; Urologic Neoplasms; Vinblastine | 2004 |
Effects of filgrastim on granulopoietic cells of mice pretreated with methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Bone Marrow; Cell Differentiation; Cell Proliferation; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Granulocyte Precursor Cells; Growth Substances; Hematopoiesis; Methotrexate; Mice; Neutropenia; Neutrophils; Recombinant Proteins; Spleen | 2005 |
Nuclear winter.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Child, Preschool; Humans; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Anemia; Antirheumatic Agents; Australia; Carbamazepine; Child; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization Review; Female; Humans; Incidence; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Neutropenia; Organogold Compounds; Pancytopenia; Thrombocytopenia | 2007 |
Adverse drug reaction to methotrexate: pharmacogenetic origin.
Topics: Antimetabolites, Antineoplastic; Female; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mucositis; Neutropenia; Pharmacogenetics; Polymorphism, Single Nucleotide; Thrombocytopenia | 2006 |
[Three cases of necrotizing pneumonia by pseudomonas aeruginosa infection in hematological malignancy, including dead and alive cases].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Hematologic Neoplasms; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Necrosis; Neutropenia; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Severity of Illness Index | 2007 |
Adverse events of MVAC chemotherapy in patients with advanced urothelial cancer of the bladder.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Neutropenia; Retrospective Studies; Serotonin Antagonists; Thrombocytopenia; Urinary Bladder Neoplasms; Vinblastine | 2007 |
[Results of modified M-VAC chemotherapy for advanced urothelial carcinoma].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neutropenia; Retrospective Studies; Survival Rate; Urinary Bladder Neoplasms; Urologic Neoplasms; Vinblastine | 2007 |
[MTX-HOPE (methotrexate, hydrocortisone, vincristine, sobuzoxane, and etoposide) as a low-dose salvage chemotherapy for recurrent or refractory non-Hodgkin's lymphoma].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Hydrocortisone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Piperazines; Salvage Therapy; Survival Rate; Thrombocytopenia; Vincristine | 2007 |
The Memorial Sloan Kettering Cancer Center experience with outpatient administration of high dose methotrexate with leucovorin rescue.
Topics: Adolescent; Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Drug Monitoring; Female; Humans; Infusions, Intravenous; Kidney; Leucovorin; Male; Methotrexate; Neutropenia; Osteosarcoma | 2008 |
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting | 2008 |
Granulocyte colony-stimulating factor induced reduction in pulpal necrosis.
Topics: Animals; Dental Pulp Necrosis; Granulocyte Colony-Stimulating Factor; Male; Methotrexate; Neutropenia; Neutrophil Infiltration; Neutrophils; Phagocytosis; Rats; Rats, Wistar; Recombinant Proteins | 2008 |
Graft-versus-host reaction in 3 adult leukaemia patients after transfusion of blood cell products.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Neutropenia; Prednisolone; Prednisone; Thioguanine; Transfusion Reaction; Vincristine | 1983 |
Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Methotrexate; Nausea; Neutropenia; Stomatitis; Vomiting | 1984 |
Surgical resection and limited chemotherapy for abdominal undifferentiated lymphomas.
Topics: Abdominal Neoplasms; Adolescent; Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Lymphoma; Male; Methotrexate; Nausea; Neutropenia; Prednisolone; Vincristine | 1984 |
IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Humans; Ifosfamide; Inflammation; Lymphoma; Methotrexate; Mucous Membrane; Neutropenia; Podophyllotoxin; Recurrence | 1982 |
[Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases].
Topics: Adult; Aged; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Itraconazole; Leukemia, Promyelocytic, Acute; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Mucormycosis; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Clostridium septicum abscess in hepatic metastases: successful medical management.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Carmustine; Ceftazidime; Cisplatin; Clindamycin; Clostridium Infections; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Gases; Granulocyte Colony-Stimulating Factor; Humans; Imipenem; Immunocompromised Host; Liver Abscess; Liver Neoplasms; Methotrexate; Neutropenia; Sepsis | 1994 |
Effects of rhG-CSF on infection complications and impaired function of neutrophils secondary to chemotherapy for non-Hodgkin's lymphoma. Hokkaido Study Group of Malignant Lymphoma, and rhG-CSF, Japan.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cell Adhesion Molecules; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Granulocyte Colony-Stimulating Factor; Humans; Infection Control; Luminescent Measurements; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neoplasm Proteins; Neutropenia; Neutrophils; Prednisone; Recombinant Proteins; Respiratory Burst; Vincristine | 1995 |
Hematopoietic growth factors in rheumatoid arthritis: a critical approach to their use in view of possible adverse effects.
Topics: Adult; Arthritis, Rheumatoid; Bone Marrow Transplantation; Cyclosporine; Female; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Neutropenia; Prednisolone | 1993 |
Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Cells; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fever; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tegafur; Time Factors | 1993 |
Effect of neutropenia on gastric mucosal integrity and mucosal nitric oxide synthesis in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Ethanol; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Male; Methotrexate; Neutropenia; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1993 |
Effect of long-term methotrexate-induced neutropenia on experimental periodontal lesion in rats.
Topics: Alveolar Bone Loss; Animals; Dental Plaque; Gram-Negative Bacteria; Leukocyte Count; Male; Methotrexate; Neutropenia; Periodontitis; Rats; Rats, Wistar | 1994 |
Low dose methotrexate therapy--toxic if not taken correctly. Adverse Drug Reactions Advisory Committee.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Australia; Bone Marrow; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Neutropenia; Stomatitis | 1994 |
[Neutropenia after the first administration of methotrexate in rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Methotrexate; Neutropenia | 1993 |
Effect of methotrexate-induced neutropenia on rat periapical lesion.
Topics: Alveolar Bone Loss; Animals; Bacterial Infections; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Dental Pulp Exposure; Immunosuppressive Agents; Leukocyte Count; Male; Methotrexate; Neutropenia; Neutrophils; Periapical Abscess; Periapical Periodontitis; Rats; Rats, Wistar | 1994 |
Severe bone marrow suppression in a patient with rheumatoid arthritis on methotrexate.
Topics: Arthritis, Rheumatoid; Bone Marrow; Female; Humans; Methotrexate; Middle Aged; Neutropenia; Pancytopenia | 1993 |
High-dose, brief duration, multiagent chemotherapy for metastatic breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fluorouracil; Follow-Up Studies; Hemorrhage; Humans; Leucovorin; Liver Neoplasms; Lung Neoplasms; Methotrexate; Middle Aged; Neutropenia; Remission Induction; Survival Rate; Thrombocytopenia | 1994 |
Intrathecal leucovorin after intrathecal methotrexate overdose.
Topics: Catheterization, Central Venous; Child; Cytarabine; Drug Overdose; Humans; Hydrocortisone; Injections, Spinal; Leucovorin; Male; Medication Errors; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Induction toxicity of a modified Memorial Sloan-Kettering-New York II Protocol in children with relapsed acute lymphoblastic leukemia: a single institution study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Female; Humans; Male; Methotrexate; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Vincristine | 1996 |
Longterm effect of methotrexate in Felty's syndrome: a 12 year followup.
Topics: Administration, Oral; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Platelets; Felty Syndrome; Follow-Up Studies; Humans; Leukocyte Count; Male; Methotrexate; Neutropenia; Spleen | 1996 |
Life-threatening neutropenia following methotrexate treatment of ectopic pregnancy: a report of two cases.
Topics: Adult; Female; Folic Acid Antagonists; Humans; Methotrexate; Neutropenia; Pregnancy; Pregnancy, Ectopic | 1996 |
[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].
Topics: Antineoplastic Agents; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Kidney; Liver; Methotrexate; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia | 1996 |
A pilot study on the use of the ProMACE-CytaBOM regimen as a first-line treatment of advanced follicular non-Hodgkin's lymphoma. Gruppo Italiano per lo Studio dei Linfomi.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Pilot Projects; Prednisone; Remission Induction; Survival Analysis; Treatment Failure; Vincristine | 1997 |
Delayed elimination of methotrexate associated with piperacillin administration.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Piperacillin; Vincristine | 1997 |
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support.
Topics: Adult; Anemia; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diarrhea; Disease Progression; Drug Combinations; Drug Therapy, Combination; Female; Humans; Leucovorin; Methotrexate; Middle Aged; Neutropenia; Survival Rate; Tegafur; Uracil | 1997 |
Role of neutrophils in cerulein-induced pancreatitis in rats: possible involvement of apoptosis.
Topics: Acute Disease; Amylases; Animals; Apoptosis; Ceruletide; Lipase; Male; Methotrexate; Microscopy, Electron; Neutropenia; Neutrophils; Pancreas; Pancreatitis; Peroxidase; Rats; Rats, Sprague-Dawley | 1997 |
Methotrexate and penicillin interaction.
Topics: Adolescent; Animals; Antirheumatic Agents; Contraindications; Drug Interactions; Humans; Macaca mulatta; Methotrexate; Neutropenia; Penicillins | 1998 |
Long-term follow-up of non-Hodgkin's lymphoma patients treated with ProMACE-CytaBOM: an effective regimen for the intermediate grade subtype.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Survival Rate; Treatment Outcome; Vincristine | 1998 |
Intensified adjuvant cyclophosphamide, methotrexate and 5-fluorouracil therapy: a dose-finding study for ambulatory patients with breast cancer.
Topics: Adult; Aged; Agranulocytosis; Alopecia; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Conjunctivitis; Cyclophosphamide; Drug Administration Schedule; Female; Fluorouracil; Gastrointestinal Diseases; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Neutropenia; Treatment Outcome; Urinary Bladder | 1999 |
High-dose leucovorin as sole therapy for methotrexate toxicity.
Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Creatinine; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Kidney; Leucovorin; Methotrexate; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia | 1999 |
Complications of systemic chemotherapy as treatment of retinoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Cyclosporine; Cytarabine; Etoposide; Female; Fever; Humans; Infant; Male; Methotrexate; Neutropenia; Organophosphorus Compounds; Retinal Neoplasms; Retinoblastoma; Thrombocytopenia; Vincristine | 2000 |
Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arthritis, Rheumatoid; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive Agents; Leukemia, T-Cell; Male; Methotrexate; Middle Aged; Neutropenia; Prednisone; Recurrence; Red-Cell Aplasia, Pure; Remission Induction; T-Lymphocytes, Cytotoxic | 2001 |
[Serious adverse effects of methotrexate therapy in patients with rheumatic arthritis].
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Fatal Outcome; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Pneumonia | 1998 |
Effect of methotrexate-induced neutropenia on pulpal inflammation in rats.
Topics: Animals; Dental Pulp; Dental Pulp Exposure; Dental Pulp Necrosis; Immunohistochemistry; Immunosuppressive Agents; Leukocyte Count; Lymphocyte Count; Male; Methotrexate; Molar; Neutropenia; Neutrophil Infiltration; Neutrophils; Periapical Abscess; Periapical Tissue; Pulpitis; Rats; Rats, Wistar; Statistics, Nonparametric; Time Factors | 2002 |
Multimodal therapy including neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) for stage IIB to IV cervical cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Neutropenia; Retrospective Studies; Survival Analysis; Treatment Outcome; Uterine Cervical Neoplasms; Vinblastine | 2002 |
Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation.
Topics: Agranulocytosis; Ampicillin; Animals; Biological Assay; Blood Platelets; Bone Marrow Cells; Bone Marrow Transplantation; Dihydrostreptomycin Sulfate; Dog Diseases; Dogs; Drug Combinations; Erythrocytes; Erythropoietin; Hypoxia; Iron; Iron Radioisotopes; Leukocyte Count; Methotrexate; Neutropenia; Periodicity; Polymyxins; Radiation Chimera; Reticulocytes; Transplantation, Homologous | 1975 |
Myelotoxicity of methotrexate in animals with pyogenic infection.
Topics: Agranulocytosis; Animals; Escherichia coli Infections; Female; Hydronephrosis; Leukocyte Count; Methotrexate; Neutropenia; Rats; Time Factors | 1977 |
Effects of varying the interval between courses of methotrexate on its myelotoxic and anti-leukaemic activities.
Topics: Animals; Body Weight; Bone Marrow Cells; Cell Count; Dose-Response Relationship, Drug; Leukemia, Experimental; Leukocyte Count; Methotrexate; Neoplasm Transplantation; Neutropenia; Neutrophils; Rats; Time Factors; Transplantation, Isogeneic | 1977 |
Combination of ametopterine (MTX) and cyclophosphamide (CPM) based on the principle of partial synchronization of cell proliferation in lung cancer. Phase II study.
Topics: Adult; Aged; Carcinoma, Bronchogenic; Cell Division; Cyclophosphamide; Drug Therapy, Combination; Humans; Lung Neoplasms; Methotrexate; Middle Aged; Neutropenia | 1976 |
[Current methods of treatment of acute lymphoblastic leukemia in children].
Topics: Acute Disease; Age Factors; Animals; Antineoplastic Agents; Asparaginase; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mitosis; Neutropenia; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Immunosuppression and immunostimulation in acute leukaemia.
Topics: Acute Disease; BCG Vaccine; Central Nervous System Diseases; Humans; Immunosuppression Therapy; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Neutropenia | 1975 |
The role of neutrophils in acute and chronic inflammation in rats.
Topics: Acute Disease; Animals; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Animal; Edema; Freund's Adjuvant; Histamine; Inflammation; Leukocyte Count; Male; Methotrexate; Neutropenia; Neutrophils; Rats; Rats, Wistar | 1992 |
Benefit of G-CSF for methotrexate-induced neutropenia in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Neutropenia | 1992 |
Lactate dehydrogenase changes during granulocyte colony-stimulating factor treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Granulocyte Colony-Stimulating Factor; Humans; L-Lactate Dehydrogenase; Leucovorin; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neutropenia; Sepsis; Vincristine | 1992 |
Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats.
Topics: Acute Disease; Animals; Aspirin; Blood Cell Count; Eicosanoids; Gastric Mucosa; Immune Sera; Leucovorin; Male; Methotrexate; Neutropenia; Neutrophils; Rats; Rats, Sprague-Dawley | 1992 |
Haemopoietic toxicity and low-dose methotrexate.
Topics: Adult; Aged; Female; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia | 1992 |
Low dose MTX and NSAID induced "mild" renal insufficiency and severe neutropenia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Methotrexate; Middle Aged; Neutropenia | 1991 |
Neutropenia due to low-dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Penicillins; Psoriasis; Retrospective Studies | 1991 |
Worsening of Felty's syndrome with methotrexate.
Topics: Felty Syndrome; Humans; Male; Methotrexate; Middle Aged; Neutropenia | 1991 |
[Effect of long-term methotrexate-induced neutropenia on experimental periodontal lesion in rats].
Topics: Animals; Methotrexate; Neutropenia; Periodontitis; Rats | 1990 |
Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process.
Topics: Animals; Immune Sera; Indomethacin; Leukotriene B4; Male; Methotrexate; Muscle, Smooth; Neutropenia; Neutrophils; Rats; Rats, Inbred Strains; Reference Values; Stomach; Stomach Ulcer | 1990 |
Cryptosporidiosis and acute leukaemia.
Topics: Child; Child, Preschool; Cryptosporidiosis; Female; Humans; Immunosuppression Therapy; Infant; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spiramycin | 1990 |
Low-dose methotrexate and severe neutropenia in patients undergoing renal dialysis.
Topics: Agranulocytosis; Dose-Response Relationship, Drug; Humans; Kidney Diseases; Methotrexate; Neutropenia; Renal Dialysis | 1990 |
Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Half-Life; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Treatment of advanced stage mycosis fungoides with bleomycin, doxorubicin, and methotrexate with topical nitrogen mustard (BAM-M).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Doxorubicin; Female; Humans; Lymphatic Metastasis; Male; Mechlorethamine; Methotrexate; Middle Aged; Mycosis Fungoides; Neutropenia; Skin Diseases; Skin Neoplasms; Splenectomy | 1986 |
Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Tolerance; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukocyte Count; Male; Methotrexate; Middle Aged; Neutropenia; Neutrophils; Recombinant Proteins; Urinary Bladder Neoplasms; Vinblastine | 1988 |
Recombinant human granulocyte colony stimulating factors: therapeutic application in the prevention of chemotherapy-induced neutropenia.
Topics: Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Colony-Stimulating Factors; Doxorubicin; Drug Evaluation; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Neoplasms; Neutropenia; Neutrophils; Recombinant Proteins; Vinblastine | 1988 |
[Effect of methotrexate-induced neutropenia on the periodontal lesion in rats].
Topics: Agranulocytosis; Animals; Methotrexate; Neutropenia; Periodontal Diseases; Rats | 1989 |
M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) chemotherapy for transitional cell carcinoma: the Princess Margaret Hospital experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Combined Modality Therapy; Doxorubicin; Humans; Kidney Neoplasms; Methotrexate; Middle Aged; Neutropenia; Ureteral Neoplasms; Urinary Bladder Neoplasms; Vinblastine | 1989 |
Felty's syndrome: a therapeutic dilemma?
Topics: Antigen-Antibody Complex; Felty Syndrome; Humans; Infections; Leukopenia; Methotrexate; Neutropenia; Splenectomy | 1989 |
Excessive chemotherapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukaemia.
Topics: Adolescent; Agranulocytosis; Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Down Syndrome; Humans; Leukemia, Lymphoid; Methotrexate; Neutropenia | 1986 |
Reversal of neutropenia with methotrexate treatment in patients with Felty's syndrome. Correlation of response with neutrophil-reactive IgG.
Topics: Aged; Agranulocytosis; Azathioprine; Enzyme-Linked Immunosorbent Assay; Felty Syndrome; Female; Humans; Immunoglobulin G; Leukocyte Count; Methotrexate; Middle Aged; Neutropenia; Neutrophils; Prednisone | 1989 |
Effects of Mega-COMLA (cyclophosphamide, cytarabine, vincristine, and methotrexate followed by leucovorin and prednisone) plus CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in the treatment of lymphoid neoplasms with very poor prognosi
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Female; Humans; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Staging; Neutropenia; Peripheral Nervous System Diseases; Prednisone; Prognosis; Thrombocytopenia; Vincristine | 1986 |
Treatment of refractory lymphoma with methotrexate, VM-26 (teniposide), procarbazine, and dexamethasone: Cancer and Leukemia Group B study 7902.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Drug Evaluation; Female; Humans; Leucovorin; Leukopenia; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Procarbazine; Teniposide; Thrombocytopenia; Vincristine | 1988 |
A new approach to the treatment of advanced high-grade non-Hodgkin's lymphoma--intensive two-phase chemotherapy.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylprednisolone; Middle Aged; Neutropenia; Procarbazine; Vincristine | 1988 |
Methotrexate in neutrophils in children with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Separation; Child; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Neutropenia; Neutrophils; Statistics as Topic | 1987 |
[Choriocarcinoma: neutropenia--acute emergency].
Topics: Adult; Agranulocytosis; Choriocarcinoma; Combined Modality Therapy; Emergencies; Female; Humans; Methotrexate; Neutropenia; Pregnancy; Uterine Neoplasms | 1987 |
Remission induction of meningeal leukemia with high-dose intravenous methotrexate.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Methotrexate; Neutropenia; Seizures; Stomatitis | 1985 |
Rheumatoid arthritis associated with expanded populations of granular lymphocytes.
Topics: Aged; Antibody-Dependent Cell Cytotoxicity; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Cyclophosphamide; Female; Humans; Killer Cells, Natural; Lymphocytes; Lymphocytosis; Male; Methotrexate; Middle Aged; Neutropenia; Phenotype; Prednisone; Rheumatoid Factor | 1986 |