Page last updated: 2024-08-25

methotrexate and Nervous System Disorders

methotrexate has been researched along with Nervous System Disorders in 73 studies

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (49.32)	18.7374
1990's	18 (24.66)	18.2507
2000's	9 (12.33)	29.6817
2010's	8 (10.96)	24.3611
2020's	2 (2.74)	2.80

Authors

Authors	Studies
Chesori, R; Gniazdowska, E; Halik, PK; Koźmiński, P	1
Banerjee, P; Bhakta, N; Brinkman, TM; Chemaitilly, W; Cheung, YT; Ehrhardt, MJ; Green, DM; Huang, IC; Hudson, MM; Hyun, G; Krull, KR; Liu, W; Mulrooney, DA; Ness, KK; Robison, LL; Srivastava, D; Williams, AM	1
Han, X; Ji, Y; Ouyang, M; Zhou, D; Zhu, T	1
Dreyer, L; Locht, H; Magyari, M; Theibich, A	1
Kim, SJ; Kim, WS; Ko, YH; Lee, JY; Lim, SH; Yoo, KH	1
Hirohata, S; Ishigatsubo, Y; Kikuchi, H; Kuwana, M; Nagafuchi, H; Sawada, T; Takeno, M	1
Bernhardt, MB; Foster, JH; Schafer, ES; Smith, EO; Thompson, PA	1
Chan, JC; Kwong, YL; Yeung, DY	1
Ayric, Z; Blau, N; Blom, H; Bode, H; Cario, H; Debatin, KM; Holzmann, K; Hopfner, KP; Kohne, E; Pannicke, U; Rump, EM; Schwarz, K; Smith, DE; Smulders, Y	1
Holodny, A; Omuro, A; Palomba, ML; Pentsova, E; Rosenblum, M	1
Biassoni, V; Casanova, M; Catania, S; Cefalo, G; Clerici, CA; Collini, P; Ferrari, A; Gandola, L; Luksch, R; Massimino, M; Meazza, C; Pallotti, F; Pecori, E; Podda, M; Poggi, G; Polastri, D; Pollo, B; Potepan, P; Riva, D; Schiavello, E; Seregni, E; Simonetti, F; Spreafico, F; Terenziani, M; Valentini, L	1
BURCHENAL, JH; DARGEON, HW; PHILIPS, FS; WHITESIDE, JA	1
Ota, T	1
Kent, PD; Luthra, HS; Michet, CJ	1
Dello Russo, C; Graziani, G; Navarra, P; Tentori, L; Tringali, G; Vairano, M	1
Arita, N	1
Kishida, S; Ota, K	1
Janas, J; Kozaczka, A; Singer, Z; Wilk, J	1
Shapiro, WR; Young, DF	1
Benson, AB; Brown, JJ; Lesser, JR; Martino, RL; Merritt, JA	1
Endoh, F; Hodaka, E; Ishii, T; Takada, N; Umeda, T	1
Maurach, R; Strian, F	2
Frank, JT; Nelson, RW	1
Brunner, KW; Gasser, AB; Tièche, M	1
Brugger, S; Greinix, HT; Höcker, P; Kalhs, P; Keil, F; Knöbl, P; Kyrle, PA; Linkesch, W; Schneider, B; Schwarzinger, I	1
Battin, M; Chessells, J; Christie, D; Leiper, AD; Neville, BG; Vargha-Khadem, F	1
Gabizon, AA; Gorodetsky, R; Mou, X; Vexler, AM	1
Feun, L; Landy, H; Markoe, AM; Snodgrass, SM	1
Bolme, P; Nilsson, C; Smedler, AC	1
Hsi, SN; Kiu, MC; Lai, GM; Liaw, CC; Lu, CS; Yang, TS	1
Hutchinson, RM; Murphy, P; Parker, A	1
Kamen, BA; Quinn, CT	1
Edelman, MJ; Houston, J; Lauder, I; Meyers, FJ	1
Abrey, LE; DeAngelis, LM; Yahalom, J	1
Achour, E; Azar, N; Belanger, C; Cassoux, N; Delattre, JY; Gerber, S; Hoang-Xuan, K; Leblond, V; Levy, V; Ribrag, V; Soussain, C; Suzan, F	1
Balzamo, M; Ceccaldi, M; de Roux-Serratrice, C; Disdier, P; Donnet, A; Félician, O; Gaudy, C; Granel, B; Manera, L; Pache, X; Raybaud, C; Serratrice, J; Swiader, L; Weiller, PJ	1
Beretta-Piccoli, M	1
Reynolds, EH	1
Aspnes, GT; Kalavsky, SM; Kammerer, BL; Klatskin, EH; McIntosh, S; O'Brien, RT; Pearson, HA; Snead, C	1
Kuzuhara, S	1
Balter, R; Battisti, L; Borgna-Pignatti, C; Caudana, R; Marradi, P	1
Snodgrass, SR	1
Bowman, WP; Buchanan, GR; Jacaruso, D; Kamen, BA; Roach, ES; Rollins, N; Winick, NJ	1
Dhondt, JL; Netter, JC; Petrus, M; Rance, F	1
de Wolff, FA; Edelbroek, PM; Keizer, HJ; Schweitzer, DH	1
Gori, E; Rossi, M; Zanardi, M; Zanna, M	1
Neijt, JP; ten Bokkel Huinink, WW; van der Burg, ME; van der Hoop, RG; van Houwelingen, C	1
Caramelli, P; Nitrini, R; Rocha, AS; Soriano, FG	1
Carbone, G; Leone, G; Marra, R; Massaro, AR; Pagano, L; Storti, S	1
Kramer, ED; Lewis, D; Packer, RJ; Raney, B; Womer, R	1
Capizzi, RL; Gabriel, DA; Neijstrom, E	1
Davis, RE	1
Brochstein, JA; Walker, RW	1
Killander, A; Simonsson, B; Smedmyr, B; Sundström, C	1
Duhra, P; Foulds, IS	1
Bouffet, E; Frappaz, D	1
Chessells, J; Leiper, AD	1
Anzai, T; Jaffe, N; Robertson, R; Takaue, Y	1
Patchell, RA; Posner, JB	1
Cáp, J; Cinkovská, S; Foltinová, A; Misíková, Z; Szabová, I	1
Harris, RF; Innes, EM; Kay, HE; Knapton, PJ; O'Sullivan, JP; Schwartz, FC; Stuart, J; Thompson, EN; Wells, DG	1
Simone, JV	1
Ceci, A; Mitolo-chieppa, D	1
Bleyer, WA; Chabner, BA; Drake, JC	1
Balikhina, GD; Brilliant, MD; Garbuzov, MI; Meshcheriakova, NA; Vorob'ev, IuI	1
Bertino, JR; DeConti, RC; Farber, LR; Levitt, M; Marsh, JC; Mitchell, MS; Skeel, RT	1
Walker, MD; Weiss, HD; Wiernik, PH	1
Schwartz, RS; Skinner, MD	1
Clifford, P; Patel, SA; Singh, S	1
Henderson, ES; Sandler, SG; Tobin, W	1

Reviews

20 review(s) available for methotrexate and Nervous System Disorders

Article	Year
Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers. International journal of molecular sciences, 2020, May-14, Volume: 21, Issue:10 Topics: Autoimmune Diseases; Folic Acid; Humans; Methotrexate; Neoplasms; Nervous System Diseases; Pharmaceutical Preparations	2020
Intrathecal chemotherapy for hematologic malignancies: drugs and toxicities. Annals of hematology, 2009, Volume: 88, Issue:3 Topics: Animals; Antineoplastic Agents; Cytarabine; Hematologic Neoplasms; Humans; Injections, Spinal; Methotrexate; Nervous System Diseases	2009
[Neuro-Behçet's disease]. Ryoikibetsu shokogun shirizu, 2003, Issue:40 Topics: Antidepressive Agents; Antipsychotic Agents; Behcet Syndrome; Cytokines; Heat-Shock Proteins; HLA-B Antigens; HLA-B51 Antigen; Humans; Mental Disorders; Methotrexate; Methylprednisolone; Nervous System Diseases; Neutrophil Activation; Prognosis; Pulse Therapy, Drug	2003
Relapsing polychondritis. Current opinion in rheumatology, 2004, Volume: 16, Issue:1 Topics: Antirheumatic Agents; Diagnosis, Differential; Glucocorticoids; Humans; Methotrexate; Nervous System Diseases; Polychondritis, Relapsing; Prognosis; Skin Diseases	2004
[Primary central nervous system lymphoma: diagnosis, management and current topics]. No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Diagnosis, Differential; Humans; Immunocompetence; Lymphoma; Methotrexate; Nervous System Diseases; Radiotherapy Dosage	2004
[Drug-induced leukoencephalopathy]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Aug-10, Volume: 96, Issue:8 Topics: Antineoplastic Agents; Brain Edema; Cisplatin; Cytarabine; Fluorouracil; Humans; Hypertensive Encephalopathy; Immunosuppressive Agents; Methotrexate; Nervous System Diseases; Syndrome	2007
Neurological complications of antineoplastic therapy. Acta neurologica Scandinavica. Supplementum, 1984, Volume: 100 Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Cisplatin; Cytarabine; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Phosphonoacetic Acid; Thymidine; Vinblastine; Vincristine	1984
[Cytostatic therapy: neurologic and psychiatric syndromes]. Medizinische Klinik, 1980, Jun-20, Volume: 75, Issue:13 Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Doxorubicin; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Nitrosourea Compounds; Procarbazine; Psychoses, Substance-Induced; Vincristine	1980
Intrathecal methotrexate-induced neurotoxicities. American journal of hospital pharmacy, 1981, Volume: 38, Issue:1 Topics: Humans; Injections; Injections, Spinal; Lumbosacral Region; Methotrexate; Nervous System Diseases; Risk	1981
A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1996, Volume: 44, Issue:9 Topics: Acute Disease; Adenosine; Biopterins; Chronic Disease; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Nervous System Diseases; Nucleic Acid Synthesis Inhibitors	1996
Neurological aspects of folate and vitamin B12 metabolism. Clinics in haematology, 1976, Volume: 5, Issue:3 Topics: Adult; Aged; Anemia, Megaloblastic; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Diseases; Child; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Metabolism, Inborn Errors; Methotrexate; Middle Aged; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1976
[Neurological disorders induced by antineoplastic drugs]. No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Division; Cisplatin; Fluorouracil; Humans; Methotrexate; Nervous System; Nervous System Diseases; Vincristine	1992
Vitamin neurotoxicity. Molecular neurobiology, 1992,Spring, Volume: 6, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Avitaminosis; Blood-Brain Barrier; Carrier Proteins; Coenzymes; Drug Interactions; Folic Acid; Humans; Injections, Spinal; Liver; Methotrexate; Nervous System Diseases; Oxidation-Reduction; Pseudotumor Cerebri; Pyridoxine; Self Medication; Vitamin A; Vitamins	1992
Clinical chemistry of folic acid. Advances in clinical chemistry, 1986, Volume: 25 Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim	1986
Neurologic complications of immunosuppressive agents. Neurologic clinics, 1988, Volume: 6, Issue:2 Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Cyclosporins; Cytarabine; Humans; Immunosuppressive Agents; Methotrexate; Muromonab-CD3; Nervous System Diseases	1988
[Methotrexate in pediatric hemato-oncology]. Pediatrie, 1987, Volume: 42, Issue:4 Topics: Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Nervous System Diseases; Osteosarcoma	1987
Neurologic complications of systemic cancer. Neurologic clinics, 1985, Volume: 3, Issue:4 Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disseminated Intravascular Coagulation; Electroencephalography; Endocarditis; Fluorouracil; Humans; Lung Neoplasms; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Nervous System Diseases; Paraneoplastic Syndromes; Pia Mater; Prognosis; Spinal Cord Compression; Spinal Cord Neoplasms; Tomography, X-Ray Computed; Vinca Alkaloids	1985
Management of childhood leukemia. Postgraduate medicine, 1974, Volume: 55, Issue:5 Topics: Alkanesulfonates; Amidines; Bone Marrow Examination; Chickenpox; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; gamma-Globulins; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Nervous System Diseases; Phenyl Ethers; Physician-Patient Relations; Pneumonia, Pneumocystis; Prednisone; Pseudomonas Infections; Recurrence; Testicular Neoplasms; Vincristine	1974
Neurotoxicity of commonly used antineoplastic agents (first of two parts). The New England journal of medicine, 1974, 07-11, Volume: 291, Issue:2 Topics: Animals; Antineoplastic Agents; Asparaginase; Brain; Brain Diseases; Fluorouracil; Humans; Leukemia; Mental Disorders; Methotrexate; Nervous System; Nervous System Diseases; Neurologic Manifestations; Syndrome	1974
Immunosuppressive therapy of immunoinflammatory diseases. Rheumatology, 1974, Volume: 5, Issue:0 Topics: Abnormalities, Multiple; Abortion, Spontaneous; Collagen Diseases; Cyclophosphamide; Female; Gastrointestinal Diseases; Hematologic Diseases; Immune System Diseases; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Diseases; Kidney Function Tests; Leukopenia; Liver Function Tests; Lymphoma; Mercaptopurine; Methotrexate; Nervous System Diseases; Pregnancy	1974

Trials

6 trial(s) available for methotrexate and Nervous System Disorders

Article	Year
Reduction of the systemic toxicity of cisplatin by intra-arterial hepatic route administration for liver malignancies. International journal of cancer, 1995, Mar-03, Volume: 60, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Kidney Diseases; Leucovorin; Liver; Liver Neoplasms; Methotrexate; Neoplasms; Nervous System Diseases; Ovarian Neoplasms; Remission Induction; Spectrophotometry, Atomic; Tumor Cells, Cultured; Vinblastine	1995
Phase I trial of paclitaxel, carboplatin, and methotrexate with granulocyte colony-stimulating factor and leucovorin in advanced transitional cell carcinoma. Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 15 Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Carcinoma, Transitional Cell; Confidence Intervals; Disease Progression; Drug Administration Schedule; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Nervous System Diseases; Neutropenia; Paclitaxel; Remission Induction; Salvage Therapy; Sepsis; Urinary Bladder Neoplasms	1997
Treatment for primary CNS lymphoma: the next step. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:17 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Female; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nervous System Diseases; Procarbazine; Radiation Injuries; Survival Analysis; Vincristine	2000
Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Disease-Free Survival; Dose-Response Relationship, Drug; Etoposide; Eye Neoplasms; Feasibility Studies; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Nervous System Diseases; Salvage Therapy; Thiotepa	2001
Incidence of neuropathy in 395 patients with ovarian cancer treated with or without cisplatin. Cancer, 1990, Oct-15, Volume: 66, Issue:8 Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Ovarian Neoplasms; Prospective Studies	1990
Combination sequential chemotherapy in advanced reticulum cell sarcoma. Cancer, 1972, Volume: 29, Issue:3 Topics: Adolescent; Adult; Aged; Agranulocytosis; Alopecia; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Drug Combinations; Female; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nervous System Diseases; Radiography, Thoracic; Remission, Spontaneous; Vincristine	1972

Other Studies

47 other study(ies) available for methotrexate and Nervous System Disorders

Article	Year
Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood. Annals of neurology, 2021, Volume: 89, Issue:3 Topics: Adult; Antimetabolites, Antineoplastic; Cancer Survivors; Cardiovascular Diseases; Chronic Disease; Cognitive Dysfunction; Cranial Irradiation; Endocrine System Diseases; Humans; Injections, Spinal; Logistic Models; Mental Status and Dementia Tests; Methotrexate; Nervous System Diseases; Neurocognitive Disorders; Neurosurgical Procedures; Neurotoxicity Syndromes; Odds Ratio; Radiation Injuries; Respiratory Tract Diseases	2021
Efficacy and safety of HD-MTX based systemic chemotherapy regimens: retrospective study of induction therapy for primary central nervous system lymphoma in Chinese. Scientific reports, 2017, 12-06, Volume: 7, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; China; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Nervous System Diseases; Progression-Free Survival; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult	2017
Demyelinizing neurological disease after treatment with tumor necrosis factor alpha-inhibiting agents in a rheumatological outpatient clinic: description of six cases. Clinical rheumatology, 2014, Volume: 33, Issue:5 Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cohort Studies; Demyelinating Diseases; Etanercept; Female; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Infliximab; Male; Methotrexate; Middle Aged; Nervous System Diseases; Outpatients; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha	2014
Pilot trial of systemic methotrexate plus R-CHOP regimen with intrathecal methotrexate for simultaneous central nervous system and systemic diffuse large B cell lymphoma. Acta haematologica, 2015, Volume: 133, Issue:2 Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Nervous System Diseases; Pilot Projects; Prednisone; Rituximab; Survival Rate; Time Factors; Vincristine	2015
Retrospective analysis of long-term outcome of chronic progressive neurological manifestations in Behcet's disease. Journal of the neurological sciences, 2015, Feb-15, Volume: 349, Issue:1-2 Topics: Adult; Aged; Aged, 80 and over; Behcet Syndrome; Chronic Disease; Disease Progression; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Nervous System Diseases; Prognosis; Retrospective Studies; Treatment Outcome	2015
Using a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity. Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:1 Topics: Acute Kidney Injury; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Fluid Therapy; Humans; Infusions, Intravenous; Methotrexate; Mucositis; Nervous System Diseases; Point-of-Care Systems; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies	2017
Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. American journal of human genetics, 2011, Feb-11, Volume: 88, Issue:2 Topics: Anemia, Megaloblastic; Child; Child, Preschool; Erythrocytes; Female; Fluoresceins; Folic Acid; Folic Acid Deficiency; Homozygote; Humans; Male; Methotrexate; Models, Molecular; Mutation; Nervous System Diseases; Pedigree; Protein Conformation; Tetrahydrofolate Dehydrogenase	2011
Chemotherapy-related magnetic resonance imaging abnormalities mimicking disease progression following intraventricular liposomal cytarabine and high dose methotrexate for neurolymphomatosis. Leukemia & lymphoma, 2012, Volume: 53, Issue:8 Topics: Aged; Antineoplastic Agents; Autopsy; Brain; Brain Injuries; Chlorambucil; Cytarabine; Disease Progression; Fatal Outcome; Humans; Injections, Spinal; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Nervous System Diseases; Positron-Emission Tomography; Recurrence; Waldenstrom Macroglobulinemia	2012
Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma. Journal of neuro-oncology, 2012, Volume: 108, Issue:1 Topics: Adolescent; Age Factors; Antineoplastic Agents; Cerebellar Neoplasms; Child; Child, Preschool; Cognition Disorders; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Maintenance Chemotherapy; Male; Medulloblastoma; Methotrexate; Myelography; Nervous System Diseases; Neuropsychological Tests; Radiotherapy Dosage; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome; Vincristine; Young Adult	2012
Intrathecal amethopterin in neurological manifestations of leukemia. A.M.A. archives of internal medicine, 1958, Volume: 101, Issue:2 Topics: Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Nervous System Diseases	1958
Primary cultures of microglial cells for testing toxicity of anticancer drugs. Toxicology letters, 2004, Mar-14, Volume: 148, Issue:1-2 Topics: Animals; Animals, Newborn; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Culture Techniques; Cell Survival; Dacarbazine; Drug Screening Assays, Antitumor; Humans; Lipopolysaccharides; Methotrexate; Microglia; Nervous System Diseases; Rats; Rats, Wistar; Temozolomide; Toxicity Tests	2004
[Non-hematologic adverse effects of cytostatic drugs]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1984, Nov-19, Volume: 39, Issue:47 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Diarrhea; Drug Eruptions; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Nervous System Diseases; Vomiting	1984
Transient neurologic dysfunction following moderate-dose methotrexate for undifferentiated lymphoma. Cancer, 1984, Nov-01, Volume: 54, Issue:9 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Lymphoma; Methotrexate; Nervous System Diseases	1984
[Evaluation of severe side effects of high-dose methotrexate in osteosarcoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:2 Topics: Adolescent; Adult; Anaphylaxis; Bone Neoplasms; Child; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Nervous System Diseases; Osteosarcoma; Sensation; Vomiting	1984
Neurologic and cardiac toxicity following iv application of methotrexate. Cancer treatment reports, 1982, Volume: 66, Issue:7 Topics: Bone Neoplasms; Breast Neoplasms; Female; Heart; Humans; Injections, Intravenous; Methotrexate; Middle Aged; Neoplasm Metastasis; Nervous System Diseases	1982
[Neurotoxic side effects of cytostatic therapy (author's transl)]. Fortschritte der Neurologie-Psychiatrie, 1981, Volume: 49, Issue:4 Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Doxorubicin; Fluorouracil; Humans; Meningitis; Methotrexate; Nervous System Diseases; Nitrosourea Compounds; Procarbazine; Vincristine	1981
Microangiopathy following allogeneic marrow transplantation. Association with cyclosporine and methylprednisolone for graft-versus-host disease prophylaxis. Transplantation, 1995, Nov-15, Volume: 60, Issue:9 Topics: Adult; Bone Marrow Transplantation; Cyclosporine; Female; Follow-Up Studies; Graft Survival; Graft vs Host Disease; Hemolysis; Humans; Hypertension; Immunosuppressive Agents; L-Lactate Dehydrogenase; Male; Methotrexate; Methylprednisolone; Middle Aged; Nervous System Diseases; Plasmapheresis; Platelet Count; Retrospective Studies; Syndrome; Transplantation, Homologous; Vascular Diseases	1995
Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia. Archives of disease in childhood, 1994, Volume: 70, Issue:4 Topics: Age Factors; Brain; Child; Child, Preschool; Cognition Disorders; Cranial Irradiation; Developmental Disabilities; Education; Female; Growth Disorders; Humans; Infant; Intelligence; Leukemia, Lymphoid; Leukemic Infiltration; Male; Methotrexate; Nervous System Diseases; Radiation Injuries; Radiotherapy; Recurrence; Whole-Body Irradiation	1994
Neurologic complications of Merkel cell carcinoma. Journal of neuro-oncology, 1994, Volume: 22, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carcinoma, Merkel Cell; Cytarabine; Fatal Outcome; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Nervous System Diseases; Skin Neoplasms	1994
Total body irradiation: a neuropsychological risk factor in pediatric bone marrow transplant recipients. Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:3 Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Anemia, Aplastic; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Injections, Spinal; Leukemia; Male; Mental Disorders; Methotrexate; Nervous System Diseases; Neuropsychological Tests; Radiation Dosage; Risk Factors; Time Factors; Whole-Body Irradiation	1995
Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma. Anti-cancer drugs, 1994, Volume: 5, Issue:4 Topics: Adolescent; Bone Neoplasms; Dose-Response Relationship, Drug; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma	1994
High grade pyrexia following bone marrow transplantation as a neurotoxic complication of high-dose chemotherapy and radiotherapy in the UKALL XII Trial. Bone marrow transplantation, 1994, Volume: 13, Issue:2 Topics: Adult; Bone Marrow Transplantation; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Fever; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United Kingdom; Whole-Body Irradiation	1994
[Psychological and behavioral disorders with good outcome in neurosarcoidosis]. La Revue de medecine interne, 2001, Volume: 22, Issue:2 Topics: Adult; Antirheumatic Agents; Cognition Disorders; Drug Therapy, Combination; Facial Paralysis; Female; Humans; Hydroxychloroquine; Magnetic Resonance Imaging; Meningitis; Methotrexate; Nervous System Diseases; Neurocognitive Disorders; Paranoid Disorders; Prednisolone; Prognosis; Sarcoidosis; Treatment Outcome	2001
[Acute lymphoblastic leukemia: hope! (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Nov-14, Volume: 67, Issue:46 Topics: Adult; Child; Doxorubicin; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Nervous System Diseases; Prednisone; Prognosis	1978
Chronic neurologic disturbance in childhood leukemia. Cancer, 1976, Volume: 37, Issue:2 Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Learning Disabilities; Leukemia; Leukemia, Lymphoid; Methotrexate; Movement Disorders; Nervous System Diseases; Prospective Studies; Radiotherapy; Seizures; Time Factors	1976
Transient neurologic disturbances in a child treated with moderate-dose methotrexate. British journal of haematology, 1992, Volume: 81, Issue:3 Topics: Brain; Cerebrovascular Disorders; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed	1992
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia. Journal of the National Cancer Institute, 1992, Feb-19, Volume: 84, Issue:4 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Etoposide; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1992
[Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency]. Archives francaises de pediatrie, 1991, Volume: 48, Issue:10 Topics: Biopterins; Child; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1991
Acute reversible neurotoxicity after intrathecal low-dose methotrexate. European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:2 Topics: Acute Disease; Female; Humans; Meningeal Neoplasms; Methotrexate; Middle Aged; Nervous System Diseases	1991
[A case of Behçet's disease with neurologic involvement: a clinical, neuroradiological, neurophysiological study and therapeutic considerations]. Recenti progressi in medicina, 1991, Volume: 82, Issue:3 Topics: Adult; Behcet Syndrome; Dexamethasone; Electroencephalography; Evoked Potentials, Somatosensory; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Nervous System Diseases; Spinal Puncture; Tomography, X-Ray Computed	1991
Neurosarcoidosis: therapeutic success with methotrexate. Postgraduate medical journal, 1990, Volume: 66, Issue:772 Topics: Adult; Facial Paralysis; Female; Humans; Methotrexate; Nervous System Diseases; Papilledema; Prednisone; Sarcoidosis	1990
Liquoral myelin basic protein in acute lymphoblastic leukemia. European journal of haematology, 1989, Volume: 42, Issue:4 Topics: Adolescent; Adult; Female; Humans; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1989
Neurologic complications in children with soft tissue and osseous sarcoma. Cancer, 1989, Dec-15, Volume: 64, Issue:12 Topics: Adolescent; Bone Neoplasms; Brain Diseases; Brain Neoplasms; Child; Humans; Methotrexate; Nervous System Diseases; Peripheral Nervous System Diseases; Retrospective Studies; Sarcoma; Seizures; Soft Tissue Neoplasms; Spinal Cord Compression	1989
High-dose methotrexate-induced neurotoxicity associated with elevation of CSF myelin basic protein. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4 Topics: Female; Humans; Lymphoma; Methotrexate; Middle Aged; Myelin Basic Protein; Nervous System Diseases	1985
Aggressive treatment improves survival in adult acute lymphoblastic leukemia. European journal of haematology, 1988, Volume: 41, Issue:5 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Transfusion; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation; Humans; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Middle Aged; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine	1988
Methotrexate-induced impairment of taste acuity. Clinical and experimental dermatology, 1988, Volume: 13, Issue:2 Topics: Adult; Folic Acid; Humans; Male; Methotrexate; Nervous System Diseases; Psoriasis; Taste	1988
Acute lymphoblastic leukaemia under 2 years. Archives of disease in childhood, 1986, Volume: 61, Issue:10 Topics: Adolescent; Age Factors; Child; Child, Preschool; England; Female; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Nervous System Diseases; Prognosis; Radiotherapy	1986
Transient neurologic disturbances induced by high-dose methotrexate treatment. Cancer, 1985, Sep-15, Volume: 56, Issue:6 Topics: Bone Neoplasms; Child; Female; Humans; Leucovorin; Male; Methotrexate; Nervous System Diseases; Osteosarcoma	1985
Consequences of intensive therapy of acute lymphoblastic leukemia in children in initial complete remission lasting more than five years. Czechoslovak medicine, 1985, Volume: 8, Issue:1 Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Leukemia, Lymphoid; Male; Mental Disorders; Mercaptopurine; Methotrexate; Nervous System Diseases; Prednisone; Time Factors; Vincristine	1985
Severe neurological damage associated with methotrexate therapy. Lancet (London, England), 1971, Sep-04, Volume: 2, Issue:7723 Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Humans; Infusions, Parenteral; Injections, Spinal; Methotrexate; Nervous System Diseases; Neurologic Manifestations; Psychoses, Substance-Induced; Time Factors	1971
Treating the nervous system in acute leukemia. Lancet (London, England), 1972, Feb-05, Volume: 1, Issue:7745 Topics: Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Nervous System Diseases; Nitrosourea Compounds; Pyrimethamine; Remission, Spontaneous; Time Factors	1972
[Neurotoxicity of some antineoplastic agents]. Bollettino della Societa italiana di biologia sperimentale, 1974, Sep-15, Volume: 50, Issue:17 Topics: Antineoplastic Agents; Child; Child, Preschool; Doxorubicin; Facial Paralysis; Humans; Infant; Leukemia; Lymphoma; Methotrexate; Motor Neurons; Myasthenia Gravis; Neoplasms; Nervous System; Nervous System Diseases; Paresthesia; Seizures; Vinblastine; Vincristine	1974
Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. The New England journal of medicine, 1973, Oct-11, Volume: 289, Issue:15 Topics: Adolescent; Adult; Child; Child, Preschool; Female; Half-Life; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Nervous System Diseases; Spinal Cord Diseases	1973
[Neuroleukemia]. Terapevticheskii arkhiv, 1974, Volume: 46, Issue:8 Topics: Adolescent; Adult; Child; Child, Preschool; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate; Nervous System Diseases; Radioisotope Teletherapy; Remission, Spontaneous	1974
Nervous system involvement in Burkitt's lymphoma in Kenya. The African journal of medical sciences, 1973, Volume: 4, Issue:2 Topics: Burkitt Lymphoma; Humans; Injections, Spinal; Kenya; Methotrexate; Nervous System Diseases; Neurologic Manifestations	1973
Letter: Methotrexate neurotoxicity. The New England journal of medicine, 1974, Jan-03, Volume: 290, Issue:1 Topics: Adult; Age Factors; Child; Humans; Injections, Spinal; Methotrexate; Nervous System; Nervous System Diseases	1974
Vincristine-induced neuropathy. A clinical study of fifty leukemic patients. Neurology, 1969, Volume: 19, Issue:4 Topics: Achilles Tendon; Action Potentials; Adult; Child; Child, Preschool; Cranial Nerves; Drug Synergism; Electrodiagnosis; Gait; Gastrointestinal Diseases; Humans; Leukemia; Male; Mercaptopurine; Methotrexate; Motor Neurons; Nervous System Diseases; Neural Conduction; Pain; Paralysis; Prednisolone; Reflex, Abnormal; Sensation; Time Factors; Vincristine	1969