Page last updated: 2024-08-25

methotrexate and Myelopathy

methotrexate has been researched along with Myelopathy in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (27.91)	18.7374
1990's	5 (11.63)	18.2507
2000's	4 (9.30)	29.6817
2010's	16 (37.21)	24.3611
2020's	6 (13.95)	2.80

Authors

Authors	Studies
Duarte, FB; Lima, TT; Nóbrega, PR; Rodrigues, PGB	1
Muramatsu, H; Nakata, T; Natsume, J; Sawamura, F; Takahashi, Y	1
Haboosheh, A; Lossos, A; Mikhelashvili, L; Vainstein, V	1
Hama, A; Matsumoto, K; Sakaguchi, H; Takeuchi, T; Yoshida, N	1
Abou Dalle, I; Bazarbachi, A; Bidikian, AH; El-Cheikh, J; Hourani, R	1
Chen, YC; Chiu, YH; Yang, E	1
Madaan, P; Saini, L	1
Matsuo, M; Nakamura, T	1
Baiocchi, RA; Dornbos, D; Elder, JB; Giglio, P; Otero, JJ; Puduvalli, VK; Slone, HW	1
Diong, CP; Gosavi, T; Lim, SH	1
Gollard, RP; Selco, S	1
Hosoya, Y; Kumagai, MA; Matsuoka, K; Mori, T; Morishita, Y; Nakazawa, A; Noguchi, M; Okita, H; Satomi, K; Shioda, Y; Yoshida, M	1
Koyama, T; Shintaku, M; Teraoka, S; Toyooka, N; Tsudo, M	1
Akiyama, H; Hasegawa, Y; Tsuchiya, A	1
Cachia, D; Chi, L; Cortes, JE; Daver, N; Kamiya-Matsuoka, C; Kantarjian, HM; Pinnix, CC; Woodman, K	1
Ito, H; Maeba, A; Murata, KY; Nakanishi, I; Yamanegi, M	1
Cachia, D; Chi, L; Cykowski, MD; Dabaja, BS; Daver, N; Dinardo, C; Fuller, G; Garg, N; Jabbour, EJ; Jain, N; Kadia, TM; Kamiya-Matsuoka, C; Kantarjian, HM; Konopleva, M; Milgrom, SA; Ohanian, M; Pemmaraju, N; Pinnix, CC; Smith, GL; Woodman, K	1
Glenn, M; Juster-Switlyk, K; Kolb, N; Kovacsovics, T; Palmer, CA; Quigley, EP; Smith, AG; Stephens, D	1
Broussolle, C; Candessanche, JP; Marignier, R; Ninet, J; Rousset, H; Sève, P; Varron, L	1
Ackermann, R; Fornoff, F; Hattingen, E; Linnebank, M; Maurer, GD; Semmler, A; Steinbach, JP	1
Beric, V; Love, S; Rice, CM; Scolding, NJ	1
Ding, Z; Liu, L; Wang, Z; Xu, W	1
Houzen, H; Maruo, Y; Nakano, F; Sakushima, K; Sasaki, H; Tajima, Y; Yabe, I; Yoshida, K	1
Bay, A; Caksen, H; Etlik, O; Oner, AF; Yilmaz, C	1
Baughman, RP; Bradley, DA; Lower, EE	1
Counsel, P; Khangure, M	1
Wolman, L	1
Ojeda, VJ; Walters, MN	1
Grisold, W; Lutz, D; Wolf, D	1
Castel, V; Ferris, J; Prats, C	1
Bottiglieri, T; Hyland, K; Reynolds, EH	1
al Kawi, MZ; Bohlega, S; Clink, HM; Coates, R; Ernst, P; McLean, DR; Omer, S	1
Harila-Saari, AH; Kovala, TT; Lanning, BM; Tolonen, EU; Vainionpää, LK	1
Diri, E; Espinoza, CG; Espinoza, LR	1
Allen, JC	1
Reznik, M	1
Bermudez García, JM; Gil Extremera, B; Peña Yañez, A; Raya Muñóz, J; Suárez Pañeda, JR	1
Pochedly, C	1
Beck, D; de Crousaz, H; Deonna, T; Janzer, RC; Miklossy, J; von der Weid, NX	1
Beschorner, WE; Clark, AW; Patchell, RA; Santos, GW; White, CL	1
Bleyer, WA; Chabner, BA; Drake, JC	1

Reviews

5 review(s) available for methotrexate and Myelopathy

Article	Year
Intrathecal methotrexate induced myelopathy, rare yet serious complication: A case report and review of the literature. Current research in translational medicine, 2021, Volume: 69, Issue:3 Topics: Adult; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases	2021
Spinal cord disorders in patients with cancer. Pathology annual, 1984, Volume: 19 Pt 2 Topics: Anemia, Pernicious; Central Nervous System Diseases; Encephalomyelitis; Humans; Infections; Methotrexate; Motor Neurons; Neoplasm Metastasis; Neoplasms; Nerve Degeneration; Neuromuscular Diseases; Paraneoplastic Syndromes; Radiation Injuries; Spinal Cord; Spinal Cord Diseases; Spinal Cord Injuries	1984
The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs, 1994, Volume: 48, Issue:2 Topics: AIDS Dementia Complex; Animals; Brain Diseases; Dementia; Disease Models, Animal; Epilepsy; Humans; Metabolism, Inborn Errors; Methotrexate; Methylation; Multiple Sclerosis; Neurotransmitter Agents; Parkinson Disease; Receptors, Neurotransmitter; S-Adenosylmethionine; Spinal Cord Diseases	1994
The effects of cancer therapy on the nervous system. The Journal of pediatrics, 1978, Volume: 93, Issue:6 Topics: Acute Disease; Antineoplastic Agents; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Chronic Disease; Humans; Methotrexate; Neoplasms; Peripheral Nervous System Diseases; Radiotherapy; Spinal Cord Diseases; Time Factors; Vincristine	1978
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia. Medical and pediatric oncology, 1991, Volume: 19, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Coma; Cytarabine; Female; Humans; Injections, Spinal; Methotrexate; Neoplasm Recurrence, Local; Paralysis; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases	1991

Trials

2 trial(s) available for methotrexate and Myelopathy

Article	Year
Effect of isolated central nervous system leukaemia on bone marrow remission and survival in childhood acute lymphoblastic leukaemia. A report for Children's Cancer Study Group. Lancet (London, England), 1981, Jun-27, Volume: 1, Issue:8235 Topics: Adolescent; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy, High-Energy; Random Allocation; Remission, Spontaneous; Risk; Spinal Cord Diseases	1981
[A case of idiopathic transverse acute myelopathy with a favorable response to intravenous methotrexate associated to corticoids]. Revista clinica espanola, 1978, Jan-15, Volume: 148, Issue:1 Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Hemiplegia; Humans; Injections, Intravenous; Male; Methotrexate; Methylprednisolone; Nitrofurantoin; Spinal Cord Diseases; Tablets	1978

Article

Year

Effect of isolated central nervous system leukaemia on bone marrow remission and survival in childhood acute lymphoblastic leukaemia. A report for Children's Cancer Study Group.

Lancet (London, England), 1981, Jun-27, Volume: 1, Issue:8235

Topics: Adolescent; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy, High-Energy; Random Allocation; Remission, Spontaneous; Risk; Spinal Cord Diseases

1981

[A case of idiopathic transverse acute myelopathy with a favorable response to intravenous methotrexate associated to corticoids].

Revista clinica espanola, 1978, Jan-15, Volume: 148, Issue:1

Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Hemiplegia; Humans; Injections, Intravenous; Male; Methotrexate; Methylprednisolone; Nitrofurantoin; Spinal Cord Diseases; Tablets

1978

Other Studies

36 other study(ies) available for methotrexate and Myelopathy

Article	Year
Myelopathy associated with intrathecal methotrexate. Practical neurology, 2022, Volume: 22, Issue:2 Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration; Young Adult	2022
Dorsal myelopathy after nelarabine and intrathecal methotrexate therapy. Pediatrics international : official journal of the Japan Pediatric Society, 2022, Volume: 64, Issue:1 Topics: Arabinonucleosides; Humans; Injections, Spinal; Methotrexate; Spinal Cord Diseases	2022
Intrathecal cytosine arabinoside-induced progression of chronic methotrexate myelopathy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021, Volume: 42, Issue:3 Topics: Chronic Disease; Cytarabine; Humans; Injections, Spinal; Methotrexate; Spinal Cord Diseases	2021
Acute myelopathy during chemotherapy for childhood acute lymphoblastic leukemia. Pediatrics international : official journal of the Japan Pediatric Society, 2021, Volume: 63, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases	2021
Ascending myelopathy after intrathecal methotrexate. The Kaohsiung journal of medical sciences, 2021, Volume: 37, Issue:11 Topics: Adult; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Female; Humans; Injections, Spinal; Leucovorin; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Methotrexate; Peripheral Blood Stem Cell Transplantation; Prednisone; Spinal Cord; Spinal Cord Diseases; Vitamin B 12	2021
Methotrexate myelopathy. Brain & development, 2019, Volume: 41, Issue:7 Topics: Copper; Folic Acid; Humans; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration	2019
Reply to the Letter, "Methotrexate myelopathy: A mimicker of subacute combined degeneration of the spinal cord". Brain & development, 2019, Volume: 41, Issue:7 Topics: Copper; Folic Acid; Humans; Methotrexate; Spinal Cord; Spinal Cord Diseases; Subacute Combined Degeneration	2019
Spinal Cord Toxicity from Intrathecal Chemotherapy: A Case with Clinicopathologic Correlation. World neurosurgery, 2019, Volume: 128 Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dendritic Cells; Electrodiagnosis; Evoked Potentials, Somatosensory; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Spinal Cord Neoplasms; Treatment Outcome	2019
Methotrexate-induced myelopathy mimicking subacute combined degeneration of the spinal cord. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:7 Topics: Adult; Antimetabolites, Antineoplastic; Diagnosis, Differential; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration	2013
Irreversible myelopathy associated with nelaribine in T-cell acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Disease Progression; Fatal Outcome; Humans; Injections, Spinal; Male; Mediastinal Neoplasms; Mercaptopurine; Methotrexate; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Quadriplegia; Spinal Cord; Spinal Cord Diseases	2013
Myelopathy mimicking subacute combined degeneration in a Down syndrome patient with methotrexate treatment for B lymphoblastic leukemia: report of an autopsy case. Neuropathology : official journal of the Japanese Society of Neuropathology, 2014, Volume: 34, Issue:4 Topics: Antimetabolites, Antineoplastic; Down Syndrome; Female; Folic Acid Antagonists; Humans; Leukemia, B-Cell; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration; Young Adult	2014
Methotrexate myelopathy with extensive transverse necrosis: report of an autopsy case. Neuropathology : official journal of the Japanese Society of Neuropathology, 2014, Volume: 34, Issue:6 Topics: Aged; Female; Folic Acid Antagonists; Humans; Methotrexate; Necrosis; Spinal Cord Diseases; Waldenstrom Macroglobulinemia	2014
Spinal sarcoidosis presenting with epiconus syndrome. Internal medicine (Tokyo, Japan), 2014, Volume: 53, Issue:21 Topics: Aged; Anti-Inflammatory Agents; Central Nervous System Diseases; Humans; Immunosuppressive Agents; Lumbar Vertebrae; Male; Methotrexate; Methylprednisolone; Sarcoidosis; Spinal Cord Diseases; Syndrome; Thoracic Vertebrae	2014
Myelopathy following intrathecal chemotherapy in adults: a single institution experience. Journal of neuro-oncology, 2015, Volume: 122, Issue:2 Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases	2015
Methotrexate myelopathy after intrathecal chemotherapy: a case report. Journal of medical case reports, 2015, Jun-09, Volume: 9 Topics: Antimetabolites, Antineoplastic; Demyelinating Diseases; Fatal Outcome; Humans; Injections, Spinal; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Spinal Cord; Spinal Cord Diseases	2015
Dorsal column myelopathy after intrathecal chemotherapy for leukemia. American journal of hematology, 2017, Volume: 92, Issue:2 Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration	2017
MTHFR C677T polymorphism is associated with methotrexate-induced myelopathy risk. Neurology, 2017, 02-07, Volume: 88, Issue:6 Topics: Antimetabolites, Antineoplastic; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Spinal Cord Diseases	2017
Spinal cord sarcoidosis: report of seven cases. European journal of neurology, 2009, Volume: 16, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Cyclophosphamide; Female; Fungemia; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Sarcoidosis; Severity of Illness Index; Spinal Cord; Spinal Cord Diseases	2009
Methotrexate-induced myelopathy responsive to substitution of multiple folate metabolites. Journal of neuro-oncology, 2010, Volume: 97, Issue:3 Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Humans; Magnetic Resonance Imaging; Meningeal Carcinomatosis; Methionine; Methotrexate; Middle Aged; Spinal Cord Diseases; Vitamin B Complex	2010
Neurological picture. Vertebral sarcoidosis mimicking metastases. Journal of neurology, neurosurgery, and psychiatry, 2011, Volume: 82, Issue:2 Topics: Anti-Inflammatory Agents; Biopsy; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Low Back Pain; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Neoplasm Metastasis; Prednisolone; Sarcoidosis; Spinal Cord Diseases	2011
The effect of cerebral spinal fluid replacement on acute myelopathy induced by intrathecal therapy of leukemia. Leukemia research, 2011, Volume: 35, Issue:6 Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cerebrospinal Fluid; Cytarabine; Dexamethasone; Female; Fluid Therapy; Humans; Injections, Spinal; Methotrexate; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Treatment Outcome	2011
Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients. Journal of neurology, 2011, Volume: 258, Issue:12 Topics: Adrenal Cortex Hormones; Adult; Age of Onset; Aged; Central Nervous System Diseases; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peptidyl-Dipeptidase A; Retrospective Studies; Sarcoidosis; Spinal Cord Diseases; Young Adult	2011
Myelopathy due to intrathecal chemotherapy: report of six cases. Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:5 Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Folic Acid Antagonists; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases	2005
Diagnosis and management of spinal cord sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2006, Volume: 23, Issue:1 Topics: Adult; Azathioprine; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisone; Radiography; Sarcoidosis; Spinal Cord Diseases; Treatment Outcome	2006
Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings. Clinical radiology, 2007, Volume: 62, Issue:2 Topics: Adult; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases	2007
The neuropathological effects resulting from the intrathecal injection of chemical substances. Paraplegia, 1966, Volume: 4, Issue:2 Topics: Adrenal Cortex Hormones; Anesthesia, Spinal; Anti-Bacterial Agents; Antineoplastic Agents; Benzoates; Contrast Media; Ephedrine; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Methylene Blue; Middle Aged; Phenols; Phenothiazines; Procaine; Propylene Glycols; Spinal Cord Diseases; Sulfonamides	1966
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-1984. Childhood leukemia with progressive neurologic deterioration. The New England journal of medicine, 1984, Sep-06, Volume: 311, Issue:10 Topics: Adolescent; Amygdala; Brain; Brain Diseases; Hippocampus; Humans; Leukemia, Lymphoid; Male; Methotrexate; Necrosis; Radiography; Radiotherapy; Spinal Cord; Spinal Cord Diseases	1984
Necrotizing myelopathy associated with acute lymphoblastic leukemia. Case report and review of literature. Acta neuropathologica, 1980, Volume: 49, Issue:3 Topics: Adolescent; Autopsy; Humans; Leukemia, Lymphoid; Male; Methotrexate; Necrosis; Spinal Cord Diseases	1980
[CNS prophylaxis in acute lymphoblastic leukemia (author's transl)]. Anales espanoles de pediatria, 1980, Volume: 13, Issue:1 Topics: Administration, Oral; Antineoplastic Agents; Brain Diseases; Child; Child, Preschool; Cobalt Radioisotopes; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy; Spinal Cord Diseases	1980
Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes. Cancer, 1994, Jun-15, Volume: 73, Issue:12 Topics: Adolescent; Antineoplastic Agents; Contrast Media; Cytarabine; Drug Combinations; Female; Gadolinium DTPA; Humans; Injections, Spinal; Magnetic Resonance Imaging; Meglumine; Methotrexate; Organometallic Compounds; Paraplegia; Pentetic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases	1994
Nerve lesions after therapy for childhood acute lymphoblastic leukemia. Cancer, 1998, Jan-01, Volume: 82, Issue:1 Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Axons; Brachial Plexus; Case-Control Studies; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Demyelinating Diseases; Evoked Potentials, Somatosensory; Female; Humans; Male; Median Nerve; Methotrexate; Motor Skills; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Reflex, Stretch; Risk Factors; Spinal Cord; Spinal Cord Diseases; Tibial Nerve; Vincristine	1998
Spinal cord granulomatous vasculitis: an unusual clinical presentation of sarcoidosis. The Journal of rheumatology, 1999, Volume: 26, Issue:6 Topics: Biopsy; Humans; Male; Methotrexate; Middle Aged; Prednisone; Sarcoidosis; Spinal Cord Diseases; Treatment Outcome; Vasculitis	1999
Acute ascending poliomyelomalacia after treatment of acute lymphocytic leukemia. Acta neuropathologica, 1979, Feb-15, Volume: 45, Issue:2 Topics: Adolescent; Female; Humans; Ischemia; Leukemia, Lymphoid; Methotrexate; Spinal Cord; Spinal Cord Diseases	1979
Neurotoxicity due to CNS therapy for leukemia. Medical and pediatric oncology, 1977, Volume: 3, Issue:1 Topics: Adolescent; Brain Diseases; Central Nervous System Diseases; Child; Humans; Infections; Leukemia; Methotrexate; Paralysis; Radiotherapy; Spinal Cord Diseases	1977
Neurologic complications of bone marrow transplantation. Neurology, 1985, Volume: 35, Issue:3 Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Diseases, Metabolic; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Child; Child, Preschool; Female; Graft vs Host Disease; Humans; Infections; Leukemia; Male; Methotrexate; Middle Aged; Necrosis; Neoplasms; Postoperative Complications; Seizures; Spinal Cord Diseases	1985
Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia. The New England journal of medicine, 1973, Oct-11, Volume: 289, Issue:15 Topics: Adolescent; Adult; Child; Child, Preschool; Female; Half-Life; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Nervous System Diseases; Spinal Cord Diseases	1973