Page last updated: 2024-08-25

methotrexate and Liver Dysfunction

methotrexate has been researched along with Liver Dysfunction in 128 studies

Research

Studies (128)

Timeframe	Studies, this research(%)	All Research%
pre-1990	58 (45.31)	18.7374
1990's	29 (22.66)	18.2507
2000's	21 (16.41)	29.6817
2010's	7 (5.47)	24.3611
2020's	13 (10.16)	2.80

Authors

Authors	Studies
Passens, D; Schlaak, JF	1
Frankowski, M; Gomułkiewicz, M; Korman, L; Skoczyńska, M; Starba, A; Świerkot, J	1
Gu, R; Han, H; Lu, K; Lu, Y; Qian, C; Shi, H; Tao, R; Wei, Z; Xia, Y; Zhao, Y	1
Acar, H; Bora, ES; Erbaş, O; Sorgun, O; Yurtseve, G	1
Feng, Y; Guan, Y; Liang, D; Sun, W; Wang, C; Xu, Y; Zhao, S	1
Arias-de la Rosa, I; Barbarroja, N; Collantes-Estévez, E; Cordoba, J; Cuesta-López, L; Escudero-Contreras, A; Gahete, MD; González, A; Leiva-Cepas, F; López-Pedrera, C; Lucendo, AJ; Navarro, P; Ortega, R; Pérez-Pampin, E; Pérez-Sánchez, C; Ruiz-Ponce, M	1
Chandran, V; Cook, RJ; Gladman, DD; Pakchotanon, R; Ye, JY	1
Chandwar, K; Hazarika, K; Prasanna, D; Sahoo, RR; Wakhlu, A	1
Goudarzi, M; Kalantar, H; Kalantar, M; Kalantari, H; Khodayar, MJ; Khorsandi, L; Roghani, M	1
Gamoh, M; Igarashi, T; Kondo, H; Kudo, M; Ohyanagi, M; Okazaki, S; Takahashi, T; Watanabe, R	1
Abhishek, A; Aithal, GP; Card, T; Doherty, M; Grainge, MJ; Mallen, CD; Nakafero, G; Taal, MW; Zhang, W	1
Gau, SY	1
Gelfand, JM; Syed, MN	1
Berti, E; Damiani, G; Fiore, M; Leone, S; Maraolo, AE	1
Fisher, SE; Rabinowitz, SS; Schwarz, SM; Vo, HD; Xu, J	1
Addeo, R; D'Angelo, V; Iannotta, A; Ramaglia, M	1
Avsar, E; Ergun, T; Ozgen, Z; Seckin, D; Tula, E	1
Andrews, M; Armour, K; Baker, C; Foley, P; Gebauer, K; George, J; Gupta, M; Rademaker, M; Rubel, D; Sullivan, J	1
Paul, C; Prey, S	1
Anasetti, C; Appelbaum, FR; Carnevale-Schianca, F; Carpenter, PA; Deeg, HJ; Furlong, T; Kiem, HP; Leisenring, W; Martin, PJ; McDonald, GB; Nash, RA; Schoch, G; Storb, R	1
Abdelgadir, I; Chande, N; Gregor, J	1
Binard, A; Devauchelle-Pensec, V; Fautrel, B; Flipo, RM; Jousse-Joulin, S; Le Boëdec, M; Le Loët, X; Marhadour, T; Ménard, JF; Saraux, A	1
Kaur, I; Kumar, B; Saraswat, A	1
Davis, GL; Keeffe, EB	1
Vega, RS	1
Aker, M; Bloom, AI; Nagler, A; Or, R; Resnick, IB; Sasson, T; Shapira, MY; Slavin, S; Verstanding, A; Zilberman, I	1
Cañas, C; Condom, E; Del Blanco, J; Guardiola, J; Juanola, X; Rebasa, P; Riera, J; Roig-Escofet, O; Ros, S; Valverde, J	1
Hirohata, S	1
RAWSON, AJ; YANOFF, M	1
BIGNOTTI, G; TOGNELLA, S	1
AUERBACH, R; BLACK, RL; BUNIM, JJ; EISEN, AZ; O'BRIEN, WM; VANSCOTT, EJ	1
HALL, TC; NGU, VA; ROBERTS, D	1
CASTELLS, J; MESCHAN, I	1
Burrows, P; Chalmers, RJ; Hextall, JM; Horan, M; Kirby, B; Klaber, M; Little, R; Rogers, S; Smith, A; Smith, CH	1
Höök-Nikanne, J; Kärkkäinen, P; Niemelä, S; Nieminen, U	1
Beck, JF; Dölken, R; Harms, D; Hartwig, M; Schröder, H; Weigel, S	1
Berends, MA; de Jong, EM; Drenth, JP; Snoek, J; van de Kerkhof, PC; van Krieken, JH; van Oijen, MG	1
Hayakawa, A; Imanishi, H; Matsuo, M; Moriya, Y; Nakamura, T; Noro, Y; Okamura, N; Okumura, K; Sakaeda, T; Takeshima, Y; Yagi, M	1
Avsar, E; Aygun, C; Celikel, C; Eren, F; Haklar, G; Hulagu, S; Senturk, O; Tahan, V; Tozun, N; Unluguzel, G; Uraz, S; Yuksel, M	1
Berends, MA; de Jong, EM; Drenth, JP; Han van Krieken, J; Snoek, J; van de Kerkhof, PC; van Oijen, MG	1
Flechtenmacher, C; Longerich, T; Schirmacher, P	1
Aldershvile, J; Hardt, F; Møller, AM; Nielsen, JO; Nyfors, A; Tage-Jensen, U; Veien, NK	1
Powis, G	1
Rubin, P	1
Hoffmeister, RT	1
Beckett, GJ; Elmahallawy, M; Fletcher, PJ; Lawrence, CM; Scriven, AJ; Strange, RC; Summerly, R; Wood, A	1
Auerbach, R; Geronemus, RG; Tobias, H	1
Albano, A; Bandiera, F; Biano, F; Maccario, G; Orlando, T	1
Sitzmann, FC	1
Auerbach, R; Baughman, RD; Cimis, RJ; Robinson, JK	1
Erickson, AR; Reddy, V; Vogelgesang, SA; West, SG	1
Baughman, RD; Cimis, R; Jones, R; Kneeland, T; Littenberg, B; Morrison, E; Nease, RF; O'Connor, GT; Sumner, W; Zug, KA	1
Davis, DE; Harrington, TM; Newman, ED; Perruquet, JL; Torretti, D	1
Grant-Kels, JM; Grin-Jorgensen, C; Ramsey, WH; Rothe, MJ	1
Catsoulakos, P; Karakiulakis, G; Pispirigos, K	1
Grant-Kels, JM; Grin-Jorgensen, C; Petrazzuoli, M; Ramsey, WH; Rothe, MJ	1
Jaskiewicz, K; Robson, SC; Voigt, MD	1
Alarcón, GS; Dent, PB; Furst, DE; Kremer, JM; Lightfoot, RW; Weinblatt, ME; Williams, HJ; Willkens, RF	1
Buijs, WC; Corstens, FH; de Boo, T; Duller, P; Kniest, PH; Kuijpers, AL; Nagengast, FM; van de Kerkhof, PC; vanDooren-Greebe, RJ; Willems, JL	1
Avalos, B; Biggs, J; Brodsky, I; Copelan, E; Crilley, P; Downs, K; Marks, DI; Moul, J; Penza, S; Sabol, P; Styler, MJ; Szer, J; Topolsky, D	1
Blotner, SD; Furst, DE; Kremer, JM; Weinblatt, ME	1
Boffa, MJ; Chalmers, RJ; Haboubi, NY; Mitchell, DM; Rowan, B; Shomaf, M; Smith, A; Warnes, TW	1
Bowman, WP; Buchanan, GR; Farrow, AC; Winick, NJ; Zwiener, RJ	1
Connaghan, DG; Devine, SM; Dix, SP; Fitzsimmons, WE; Geller, RB; Heffner, LT; Hillyer, CD; Holland, HK; Keller, J; Lin, LB; Maher, RM; Maurer, D; O'Toole, K; Rodey, GE; Wingard, JR; Winton, EF	1
Levin, DM	1
Hirvikoski, PP; Johansson, RT; Kumpulainen, EJ	1
Brooks, RH; Pincus, T; Stein, CM	1
Auerbach, R; Lebwohl, M; Maibach, H; Roenigk, HH; Weinstein, G	1
Baughman, RP	2
Bailey, M; Chapin, W; Licht, H; Reynolds, JC	1
Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP	1
Bennoun, M; Briand, P; Caron de Fromentel, C; Gillet, R; Grimber, G; Joulin, V	1
Boffa, MJ; Chalmers, RJ; Kirby, B; Smith, A	1
Goto, E; Okamoto, I; Tanaka, K; Tomojiri, S	1
Moix, FM; Raufman, JP	1
Chan, H; Evans, WE; Pratt, CB	1
Grunnet, E; Sogaard, H; Zachariae, H	1
Scheuer, PJ	1
Benson, J; Chessells, JM; Squier, MV; Topley, JM	1
Allen, RM; Bloomer, JR; Klatskin, G; Kobayashi, K	1
Freeman-Narrod, M	1
Nyfors, A; Poulsen, H	2
Brandão, M; Campos, MC; Loureiro, M; Pecegueiro, M; Themido, R	1
Ang, PT; Chua, EJ; Ong, YW; Sng, I; Soh, LT	1
Cash, JM; Crofford, LJ; Di Bisceglie, AM; Swain, M; Wilder, RL	1
Chamuleau, RA; Cohen, EB; van Everdingen, JJ; Verschuur, AC	1
Cera, PJ; Mangan, TF; Newman, ED; Phillips, CA	1
Anasetti, C; Appelbaum, FR; Beatty, PG; Byers, V; Doney, K; Fisher, L; Martin, PJ; McDonald, GB; Sanders, JE; Schoch, G	1
Pulczynska, M; Schmiegelow, K	1
Brick, JE; Chang, WL; Kujala, GA; Shamma'a, JM	1
Kaplan, MM	1
Borislow, DS; Davis, I	1
Auerbach, R; Maibach, HI; Roenigk, HH; Weinstein, GD	1
Lewis, JH; Schiff, E	1
Aponte, J; Petrelli, M	1
Bjorkman, DJ; Clegg, DO; Hammond, EH; Lee, RG; Tolman, KG	1
Collins, M; Lawrence, CM; Paramsothy, J; Sharif, H; Shaw, P; Strange, R	1
Koudstaal, J; Maesen, FP; van Deursen, CT	1
Hijiya, N; Ise, T; Kanagawa, S; Kitabayashi, T; Matsushita, T; Yamaguchi, M	1
Deeg, HJ; Storb, R	1
Flynn, BM; Treves, ST	1
Malatjalian, DA; McCauley, D; Ross, JB; Turnbull, GK; Williams, CN	1
Kollberg, B; Sandstedt, B; Szanto, E	1
Camuto, P; Feiner, H; Orbuch, P; Shupack, J; Sidhu, G; Tobias, H	1
Clegg, DO; Lee, RG; Tolman, KG; Ward, JR	1
Appelbaum, FR; Banaji, M; Bensinger, WI; Buckner, CD; Clift, RA; Deeg, HJ; Flournoy, N; Kennedy, MS; Storb, R; Thomas, ED	1
Appelbaum, FR; Beatty, P; Bensinger, W; Buckner, CD; Clift, R; Deeg, HJ; Doney, K; Irle, C; Kennedy, M; Storb, R	1
Dodd, H; Kirby, JD; Lees, WR; Levene, GM; Miller, JA; Munro, DD; Rustin, MH	1
Kremer, JM	1
Arnold, GL; Gowans, JD; Kaplan, MM; Lanse, SB	1
Hoefnagels, WH; Mali, JW; van de Kerkhof, PC; van Haelst, UJ	1
Hendel, J; Nyfors, A; Nyfors, B; Poulsen, H	1
Farouhar, F; Korn, J; Marlowe, S; Weinstein, A	1
Dusek, J; Horák, I; Tomík, F; Vavrecka, A	1
Schiodt, T; Zachariae, H	1
Dietz, O; Pachaly, A; Schillat, I	1
Lee, JC; Maibach, HI; Shapiro, HA; Trowbridge, JO	1
Braun, HJ	1
Palmer, HM	1
Rustia, M; Shubik, P	1
Auerbach, R; Tobias, H	1
Akerman, M; Berge, G; Lundquist, A; Rorsman, H	1
Baggett, RT; Bird, RM; Hampton, JW	1
Yoshino, T	1
Talerman, A; Thompson, RB	1

Reviews

21 review(s) available for methotrexate and Liver Dysfunction

Article	Year
Liver Illness and Psoriatic Patients. BioMed research international, 2018, Volume: 2018 Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Inflammation; Liver; Liver Diseases; Methotrexate; Psoriasis	2018
The liver in pediatric gastrointestinal disease. Journal of pediatric gastroenterology and nutrition, 2014, Volume: 59, Issue:3 Topics: Adolescent; Antibodies, Monoclonal; Azathioprine; Celiac Disease; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cholagogues and Choleretics; Cholangitis, Sclerosing; Cystic Fibrosis; Humans; Infant; Inflammatory Bowel Diseases; Infliximab; Liver Diseases; Liver Function Tests; Mercaptopurine; Methotrexate; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid	2014
The Australasian Psoriasis Collaboration view on methotrexate for psoriasis in the Australasian setting. The Australasian journal of dermatology, 2017, Volume: 58, Issue:3 Topics: Alcohol Drinking; Australia; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Monitoring; Drug Therapy, Combination; Humans; Liver Diseases; Methotrexate; New Zealand; Psoriasis; Reproductive Health	2017
Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. The British journal of dermatology, 2009, Volume: 160, Issue:3 Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Eruptions; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Immunosuppressive Agents; Leucovorin; Liver Diseases; Methotrexate; Psoriasis; Randomized Controlled Trials as Topic	2009
The safety and tolerability of methotrexate for treating patients with Crohn's disease. Journal of clinical gastroenterology, 2011, Volume: 45, Issue:7 Topics: Adult; Crohn Disease; Female; Humans; Immunosuppressive Agents; Liver Diseases; Male; Methotrexate; Remission Induction; Retrospective Studies; Treatment Outcome	2011
Baseline laboratory test abnormalities are common in early arthritis but rarely contraindicate methotrexate: study of three cohorts (ESPOIR, VErA, and Brittany). Seminars in arthritis and rheumatism, 2013, Volume: 42, Issue:5 Topics: Alanine Transaminase; Anemia; Antirheumatic Agents; Arthritis; Aspartate Aminotransferases; Cohort Studies; Contraindications; Diagnostic Tests, Routine; Early Diagnosis; Female; Humans; Leukopenia; Liver Diseases; Liver Function Tests; Male; Methotrexate; Renal Insufficiency; Systemic Inflammatory Response Syndrome; Thrombocytopenia	2013
[Efficacy of leflunomide]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:12 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Blind Method; Humans; Isoxazoles; Leflunomide; Liver Diseases; Methotrexate; Mice; Sulfasalazine	2002
[Liver damage in methotrexate-treated patients. When liver biopsy is necessary in the follow-up?]. Duodecim; laaketieteellinen aikakauskirja, 2005, Volume: 121, Issue:24 Topics: Arthritis, Rheumatoid; Biopsy, Needle; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Psoriasis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index	2005
[Quality and quantity in hepatopathology. Diagnostic and clinically relevant grading for non-tumourous liver diseases]. Der Pathologe, 2008, Volume: 29, Issue:1 Topics: Fatty Liver; Female; Humans; Liver; Liver Diseases; Liver Transplantation; Male; Methotrexate; Necrosis	2008
Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs. Cancer treatment reviews, 1982, Volume: 9, Issue:2 Topics: Antineoplastic Agents; Aspartic Acid; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Fluorouracil; Gallium; Humans; Kidney Diseases; Kinetics; Liver Diseases; Metabolic Clearance Rate; Methotrexate; Phosphonoacetic Acid; Protein Binding; Tegafur	1982
The Franz Buschke lecture: late effects of chemotherapy and radiation therapy: a new hypothesis. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:1 Topics: Antineoplastic Agents; Bleomycin; Bone Marrow Diseases; Brain Diseases; Cardiomyopathies; Carmustine; Cisplatin; Doxorubicin; Gastrointestinal Diseases; Humans; Kidney Diseases; Liver Diseases; Lung Diseases; Methotrexate; Neoplasms; Radiotherapy	1984
Monitoring patients taking methotrexate for hepatotoxicity. Does the standard of care match published guidelines? Journal of the American Academy of Dermatology, 1994, Volume: 31, Issue:6 Topics: Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Clinical Protocols; Connecticut; Drug Monitoring; Follow-Up Studies; Gastroenterology; Humans; Liver; Liver Diseases; Massachusetts; Methotrexate; Practice Guidelines as Topic; Psoriasis; Referral and Consultation	1994
Methotrexate in psoriasis: consensus conference. Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:3 Topics: Dermatologic Agents; Drug Interactions; Humans; Liver Diseases; Methotrexate; Psoriasis	1998
Methotrexate for sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 1998, Volume: 15, Issue:2 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Humans; Immunosuppressive Agents; Liver Diseases; Lung Diseases; Methotrexate; Safety; Sarcoidosis; Treatment Outcome	1998
The effects of vasculitis on the gastrointestinal tract and liver. Gastroenterology clinics of North America, 1998, Volume: 27, Issue:4 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Digestive System Diseases; Gastrointestinal Diseases; Humans; Liver Diseases; Methotrexate; Vasculitis	1998
The role of liver biopsy in the evaluation of liver test abnormalities. Clinical cornerstone, 2001, Volume: 3, Issue:6 Topics: Biopsy; Cholestasis; Diagnosis, Differential; Fever of Unknown Origin; Hepatitis; Hepatomegaly; Humans; Liver; Liver Diseases; Liver Function Tests; Liver Neoplasms; Methotrexate	2001
Long-term effects on the liver. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Anabolic Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Contraceptives, Oral, Hormonal; Humans; Lipofuscin; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Methotrexate; Oxyphenisatin Acetate; Phenacetin	1975
Methotrexate in psoriasis: revised guidelines. Journal of the American Academy of Dermatology, 1988, Volume: 19, Issue:1 Pt 1 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Humans; Liver; Liver Diseases; Methotrexate; Patient Education as Topic; Psoriasis	1988
Methotrexate-induced chronic liver injury: guidelines for detection and prevention. The ACG Committee on FDA-related matters. American College of Gastroenterology. The American journal of gastroenterology, 1988, Volume: 83, Issue:12 Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Humans; Liver Diseases; Methotrexate; Prognosis	1988
Longterm methotrexate therapy in rheumatoid arthritis: a review. The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12 Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans; Hydroxychloroquine; Liver Diseases; Liver Function Tests; Methotrexate; Penicillamine; Prednisone; Psoriasis; Risk	1985
[Clinical picture, diagnostics and therapy of amyloidoses]. Medizinische Klinik, 1972, Oct-06, Volume: 67, Issue:40 Topics: Adrenal Gland Diseases; Amyloidosis; Biopsy; Chloroquine; Chronic Disease; Gastrointestinal Diseases; Humans; Infections; Kidney Diseases; Liver Diseases; Methotrexate; Neoplasms; Pancreatic Diseases; Prognosis; Splenic Diseases	1972

Trials

8 trial(s) available for methotrexate and Liver Dysfunction

Article	Year
Significant changes in serum AST across hepatic histological biopsy grades: prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis. The Journal of rheumatology, 1996, Volume: 23, Issue:3 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Sensitivity and Specificity	1996
Serum type III procollagen aminopeptide for assessing liver damage in methotrexate-treated psoriatic patients. The British journal of dermatology, 1996, Volume: 135, Issue:4 Topics: Adult; Aged; Biomarkers; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Follow-Up Studies; Humans; Laminin; Liver Diseases; Methotrexate; Middle Aged; Peptide Fragments; Procollagen; Psoriasis; Sensitivity and Specificity	1996
The outcome of unrelated donor bone marrow transplantation in patients with hematologic malignancies using tacrolimus (FK506) and low dose methotrexate for graft-versus-host disease prophylaxis. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 1997, Volume: 3, Issue:1 Topics: Adult; Bone Marrow Transplantation; Disease-Free Survival; Drug Therapy, Combination; Female; Graft Survival; Graft vs Host Disease; Hematologic Neoplasms; Histocompatibility; Humans; Hyperglycemia; Hypertension; Immunosuppressive Agents; Infections; Kidney Diseases; Life Tables; Liver Diseases; Male; Methotrexate; Middle Aged; Pilot Projects; Safety; Survival Analysis; Tacrolimus; Transplantation, Homologous; Treatment Outcome	1997
Hepatic toxicity caused by adjuvant CMF/CNF in breast cancer patients and reversal by tamoxifen. Breast cancer research and treatment, 1997, Volume: 44, Issue:3 Topics: Acetyltransferases; Adult; Alkaline Phosphatase; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; gamma-Glutamyltransferase; Humans; Liver Diseases; Methotrexate; Middle Aged; Mitoxantrone; Tamoxifen	1997
Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis. Arthritis and rheumatism, 1997, Volume: 40, Issue:9 Topics: Alkaline Phosphatase; Antirheumatic Agents; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate	1997
Recovery from toxicity associated with high-dose methotrexate: prognostic factors. Cancer treatment reports, 1977, Volume: 61, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dehydration; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant; Kidney Diseases; Kidney Function Tests; Leucovorin; Liver Diseases; Liver Function Tests; Male; Methotrexate; Neoplasms; Pleural Effusion; Prognosis; Time Factors; Vomiting	1977
Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute nonlymphoblastic leukemia. Blood, 1985, Volume: 65, Issue:6 Topics: Acute Disease; Adolescent; Adult; Bacterial Infections; Bone Marrow Transplantation; Cyclosporins; Depression; Graft vs Host Disease; Humans; Hypertension; Kidney Diseases; Length of Stay; Leukemia; Liver Diseases; Methotrexate; Middle Aged; Mycoses; Pulmonary Fibrosis; Random Allocation	1985
Marrow transplantation for leukemia following fractionated total body irradiation. A comparative trial of methotrexate and cyclosporine. Leukemia research, 1985, Volume: 9, Issue:10 Topics: Adult; Bone Marrow Transplantation; Cyclosporins; Graft vs Host Disease; Humans; Kidney Diseases; Leukemia; Liver Diseases; Methotrexate; Middle Aged; Recurrence; Vascular Diseases; Whole-Body Irradiation	1985

Other Studies

99 other study(ies) available for methotrexate and Liver Dysfunction

Article	Year
[When should methotrexate hepatopathy be suspected and which measures are advisable?] Zeitschrift fur Rheumatologie, 2022, Volume: 81, Issue:1 Topics: Humans; Liver Diseases; Methotrexate	2022
Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis. Rheumatology international, 2022, Volume: 42, Issue:4 Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Liver Diseases; Methotrexate	2022
Modulation of Gut Microbiota by Magnesium Isoglycyrrhizinate Mediates Enhancement of Intestinal Barrier Function and Amelioration of Methotrexate-Induced Liver Injury. Frontiers in immunology, 2022, Volume: 13 Topics: Chemical and Drug Induced Liver Injury, Chronic; Gastrointestinal Microbiome; Humans; Liver Diseases; Methotrexate; Saponins; Triterpenes	2022
Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexateinduced hepatoxicity model. Acta cirurgica brasileira, 2022, Volume: 37, Issue:5 Topics: Animals; Liver Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Wistar	2022
Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity. Drug design, development and therapy, 2022, Volume: 16 Topics: Animals; Firmicutes; Gastrointestinal Microbiome; Liver Diseases; Metabolome; Metabolomics; Methotrexate; Mice; Microbiota	2022
Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis. European journal of internal medicine, 2023, Volume: 118 Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Cross-Sectional Studies; Humans; Inflammation; Liver Diseases; Longitudinal Studies; Methotrexate; Mice; Obesity; Peptides, Cyclic	2023
Liver Abnormalities in Patients with Psoriatic Arthritis. The Journal of rheumatology, 2020, 06-01, Volume: 47, Issue:6 Topics: Arthritis, Psoriatic; Humans; Liver Diseases; Longitudinal Studies; Methotrexate	2020
Lip Edema in a Young Woman-An Unusual Cause. Arthritis & rheumatology (Hoboken, N.J.), 2020, Volume: 72, Issue:9 Topics: Abdomen; Adolescent; Alkaline Phosphatase; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antirheumatic Agents; Edema; Female; Humans; Lip; Lip Diseases; Liver; Liver Diseases; Liver Function Tests; Lymph Nodes; Lymphadenopathy; Mediastinum; Methotrexate; Prednisolone; Sarcoidosis; Tomography, X-Ray Computed; Ultrasonography	2020
Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity. Drug design, development and therapy, 2020, Volume: 14 Topics: Administration, Oral; Animals; Coumaric Acids; Dose-Response Relationship, Drug; Inflammation; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Methotrexate; Mice; Oxidative Stress; Protective Agents; Structure-Activity Relationship	2020
Multidisciplinary Approach to Prevent de novo Hepatitis B in Patients with Rheumatoid Arthritis. The Tohoku journal of experimental medicine, 2020, Volume: 252, Issue:2 Topics: Aged; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interdisciplinary Communication; Liver Diseases; Male; Methotrexate; Middle Aged; Patient Care Team; Retrospective Studies	2020
What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? Rheumatology (Oxford, England), 2021, 12-01, Volume: 60, Issue:12 Topics: Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Female; Humans; Immunosuppressive Agents; Incidence; Leflunomide; Liver Diseases; Male; Methotrexate; Middle Aged; Renal Insufficiency; Rheumatic Diseases; Thrombocytopenia; United Kingdom; Withholding Treatment	2021
Methotrexate use and liver outcomes in psoriasis and rheumatoid arthritis patients: A commentary on "Risk of liver disease in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis receiving methotrexate: A population-based study". Journal of the American Academy of Dermatology, 2021, Volume: 85, Issue:6 Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Liver Diseases; Methotrexate; Psoriasis	2021
Response to: "Methotrexate Use and Liver Outcomes in Psoriasis and Rheumatoid Arthritis Patients: A Commentary on 'Risk of liver disease in patients with psoriasis, psoriatic arthritis and rheumatoid arthritis receiving methotrexate: A population-based st Journal of the American Academy of Dermatology, 2021, Volume: 85, Issue:6 Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Humans; Liver Diseases; Methotrexate; Psoriasis	2021
Pharmacogenetics of methotrexate in pediatric hematological neoplasm treatment: does it need a personalized regimen based on MTHFR polymorphisms? Expert review of hematology, 2014, Volume: 7, Issue:5 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Genotype; Hematologic Neoplasms; Humans; Infant; Liver Diseases; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precision Medicine	2014
Psoriasis and the liver: problems, causes and course. The Australasian journal of dermatology, 2017, Volume: 58, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; Child; Dermatologic Agents; Diabetes Complications; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis; Young Adult	2017
Longitudinal assessment of morbidity and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation: retrospective analysis of a multicenter phase III study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009, Volume: 15, Issue:6 Topics: Acute Disease; Clinical Trials, Phase III as Topic; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Diseases; Graft vs Host Disease; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Liver Diseases; Methotrexate; Organ Specificity; Postoperative Complications; Randomized Controlled Trials as Topic; Retrospective Studies; Skin Diseases; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous	2009
My doctor recommended I take methotrexate to relieve the pain of the rheumatoid arthritis I have in my shoulder. But I've heard that methotrexate can cause liver problems. How will I know if I'm developing liver problems? DukeMedicine healthnews, 2009, Volume: 15, Issue:11 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Liver; Liver Diseases; Methotrexate; Risk Factors; Shoulder Pain	2009
Short-term methotrexate therapy in psoriasis: a study of 197 patients. International journal of dermatology, 2002, Volume: 41, Issue:7 Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dermatologic Agents; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Psoriasis; Retrospective Studies; Severity of Illness Index; Time Factors	2002
Best of the AASLD. Highlights from the 52nd Annual Meeting of the American Association for the Study of Liver Diseases. November 9-13, 2001, Dallas, TX. Reviews in gastroenterological disorders, 2002, Volume: 2, Issue:1 Topics: Carcinoma, Hepatocellular; Cholangitis, Sclerosing; Disease Progression; Hepatitis; Hepatitis, Viral, Human; Humans; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; Liver Diseases; Liver Neoplasms; Liver Transplantation; Methotrexate	2002
Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry. Archives of pathology & laboratory medicine, 2002, Volume: 126, Issue:9 Topics: Amyloid beta-Protein Precursor; Antimetabolites, Antineoplastic; Axons; Central Nervous System Diseases; Granuloma; Humans; Immunohistochemistry; Liver Diseases; Methotrexate; Transfusion Reaction	2002
Intra-arterial catheter directed therapy for severe graft-versus-host disease. British journal of haematology, 2002, Volume: 119, Issue:3 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Bone Marrow Transplantation; Catheters, Indwelling; Child; Drug Resistance; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infusions, Intra-Arterial; Liver Diseases; Male; Methotrexate; Methylprednisolone; Middle Aged; Survival Analysis; Transplantation, Homologous; Treatment Outcome	2002
Light and electron microscopic analysis of liver biopsy samples from rheumatoid arthritis patients receiving long-term methotrexate therapy. Scandinavian journal of rheumatology, 2002, Volume: 31, Issue:6 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Microscopy, Electron; Middle Aged; Reference Values	2002
PELIOSIS HEPATIS. AN ANATOMIC STUDY WITH DEMONSTRATION OF TWO VARIETIES. Archives of pathology, 1964, Volume: 77 Topics: Anatomy; Chlorambucil; Classification; Cyclophosphamide; Dactinomycin; Femoral Fractures; Geriatrics; Liver Diseases; Mediastinal Neoplasms; Methotrexate; Neoplasm Metastasis; Norethandrolone; Parkinsonian Disorders; Pathology; Peliosis Hepatis; Phenytoin; Prostheses and Implants; Psychosurgery; Teratoma; Testosterone; Wound Healing	1964
[LABORATORY TESTS FOR VERIFYING STATES OF FOLIC ACID DEFICIENCY IN THE ORGANISM]. Recenti progressi in medicina, 1964, Volume: 36 Topics: Aminopterin; Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood; Clinical Laboratory Techniques; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Lactobacillus; Leuconostoc; Liver Diseases; Methotrexate; Neoplasms; Nutrition Disorders; Pregnancy; Staphylococcus; Urine; Vitamin B Deficiency	1964
METHOTREXATE THERAPY IN PSORIATIC ARTHRITIS; DOUBLE-BLIND STUDY ON 21 PATIENTS. JAMA, 1964, Sep-07, Volume: 189 Topics: Alopecia; Arthritis; Arthritis, Psoriatic; Biomedical Research; Double-Blind Method; Drug Eruptions; Drug Therapy; Gastrointestinal Tract; Leukopenia; Liver Diseases; Methotrexate; Psoriasis; Skin; Toxicology; Triamcinolone	1964
STUDIES ON FOLIC REDUCTASE. I. LEVELS IN REGENERATING RAT LIVER AND THE EFFECT OF METHOTREXATE ADMINISTRATION. Cancer research, 1964, Volume: 24 Topics: Folic Acid; Hepatectomy; Liver; Liver Diseases; Liver Regeneration; Methotrexate; Oxidoreductases; Pharmacology; Rats; Research	1964
THE UTILIZATION OF METHOTREXATE, AMINOPTERIN, SPLEEN HEMOGENATE, THYMUS HEMOGENATE, AND DNA AS TEST AGENTS FOR SUPPRESSION OF DNA SYNTHESIS IN REGENERATING RAT LIVER. Radiology, 1964, Volume: 83 Topics: Aminopterin; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Metabolism; Methotrexate; Pharmacology; Rats; Research; Spleen; Thymidine; Thymus Gland; Tissue Extracts; Tritium	1964
Replacement of routine liver biopsy by procollagen III aminopeptide for monitoring patients with psoriasis receiving long-term methotrexate: a multicentre audit and health economic analysis. The British journal of dermatology, 2005, Volume: 152, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Administration Schedule; Drug Monitoring; Female; Health Care Costs; Humans; Liver Diseases; Male; Medical Audit; Methotrexate; Middle Aged; Patient Satisfaction; Peptide Fragments; Practice Guidelines as Topic; Procollagen; Psoriasis	2005
Treatment of severe disseminated juvenile systemic xanthogranuloma with multiple lesions in the central nervous system. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:2 Topics: Central Nervous System Diseases; Combined Modality Therapy; Craniotomy; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Liver Diseases; Lung Diseases; Mercaptopurine; Methotrexate; Paresis; Prednisolone; Skin Diseases; Vinblastine; Xanthogranuloma, Juvenile	2006
Liver injury in long-term methotrexate treatment in psoriasis is relatively infrequent. Alimentary pharmacology & therapeutics, 2006, Sep-01, Volume: 24, Issue:5 Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk Factors; Treatment Outcome; Withholding Treatment	2006
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma. Journal of human genetics, 2007, Volume: 52, Issue:2 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Infant; Liver Diseases; Lymphoma; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors	2007
Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity. Digestive diseases and sciences, 2008, Volume: 53, Issue:4 Topics: Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Immunosuppressive Agents; Lipid Peroxidation; Liver Diseases; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Ursodeoxycholic Acid	2008
Reliability of the Roenigk classification of liver damage after methotrexate treatment for psoriasis: a clinicopathologic study of 160 liver biopsy specimens. Archives of dermatology, 2007, Volume: 143, Issue:12 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Psoriasis; Reproducibility of Results; Retrospective Studies; Severity of Illness Index; Single-Blind Method	2007
Immunoglobulin-bearing cells in the liver biopsies from patients with psoriasis. Acta dermato-venereologica, 1980, Volume: 60, Issue:6 Topics: Adolescent; Adult; Aged; Female; Humans; Immunoglobulins; Liver; Liver Diseases; Male; Methotrexate; Microscopy, Fluorescence; Middle Aged; Psoriasis	1980
Methotrexate therapy in rheumatoid arthritis: 15 years experience. The American journal of medicine, 1983, Dec-30, Volume: 75, Issue:6A Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Injections, Intramuscular; Liver; Liver Diseases; Methotrexate; Middle Aged	1983
Assessment of liver function using fasting bile salt concentrations in psoriasis prior to and during methotrexate therapy. Clinica chimica acta; international journal of clinical chemistry, 1983, Apr-25, Volume: 129, Issue:3 Topics: Adult; Aged; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Fasting; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis	1983
Liver biopsies upsilon liver scans in methotrexate-treated patients with psoriasis. Archives of dermatology, 1982, Volume: 118, Issue:9 Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Radionuclide Imaging; Retrospective Studies	1982
[Prevention and control fo side effects in the chemotherapy of advanced lung cancer]. Minerva medica, 1981, Jun-23, Volume: 72, Issue:25 Topics: Aged; Antibody Formation; Antineoplastic Agents; BCG Vaccine; Cardiomyopathies; Cyclophosphamide; Female; Humans; Immune Tolerance; Liver Diseases; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Pharyngitis; Prognosis; Vincristine	1981
[Enzyme diagnosis in children. Value and limitations]. ZFA. Zeitschrift fur Allgemeinmedizin, 1981, Sep-20, Volume: 57, Issue:26 Topics: Adolescent; Age Factors; Cardiovascular Diseases; Child; Child, Preschool; Creatine Kinase; Enzymes; Female; Humans; Infant; Leukemia; Liver Diseases; Male; Methotrexate; Muscular Diseases	1981
Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals. Archives of dermatology, 1980, Volume: 116, Issue:4 Topics: Adult; Age Factors; Aged; Bile Ducts; Biopsy; Female; Hematoma; Humans; Liver; Liver Diseases; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Time Factors	1980
Usefulness of the American College of Rheumatology recommendations for liver biopsy in methotrexate-treated rheumatoid arthritis patients. Arthritis and rheumatism, 1995, Volume: 38, Issue:8 Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost Savings; Diabetes Mellitus, Type 1; Drug Monitoring; Evaluation Studies as Topic; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Rheumatology; Risk Factors; United States	1995
Assessing the preferences of patients with psoriasis. A quantitative, utility approach. Archives of dermatology, 1995, Volume: 131, Issue:5 Topics: Adult; Aged; Attitude to Health; Biopsy; Chemical and Drug Induced Liver Injury; Decision Making; Female; Forecasting; Health Status; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Patient Satisfaction; Psoriasis; Quality of Life; Time Factors; Treatment Outcome	1995
Creating a care-effective cost-effective strategy for methotrexate liver toxicity monitoring in rheumatoid arthritis: comment on the article by Kremer et al. Arthritis and rheumatism, 1995, Volume: 38, Issue:2 Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Delivery of Health Care; Humans; Liver Diseases; Methotrexate	1995
Monitoring patients taking methotrexate. Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:4 Topics: Alanine Transaminase; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Drug Monitoring; Humans; Liver; Liver Diseases; Methotrexate; Serum Albumin	1995
Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats. Biochemistry and molecular biology international, 1993, Volume: 31, Issue:3 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Azasteroids; Blood Glucose; Chemical and Drug Induced Liver Injury; Chlorambucil; Cholesterol; Cisplatin; Epirubicin; gamma-Glutamyltransferase; Kidney; Kidney Diseases; Liver Diseases; Male; Methotrexate; Nitrogen; Nitrogen Mustard Compounds; Potassium; Rats; Rats, Wistar; Sodium; Weight Loss	1993
Distribution of hepatic nerve fibers in liver diseases. Digestion, 1994, Volume: 55, Issue:4 Topics: Autonomic Nervous System; Extracellular Matrix Proteins; Fibronectins; Hepatitis, Alcoholic; Humans; Hypertension, Portal; Laminin; Liver; Liver Cirrhosis, Alcoholic; Liver Diseases; Methotrexate; Nerve Fibers; Portal Vein; Psoriasis	1994
Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology. Arthritis and rheumatism, 1994, Volume: 37, Issue:3 Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate; Risk Factors	1994
The value of dynamic hepatic scintigraphy and serum aminoterminal propeptide of type III procollagen for early detection of methotrexate-induced hepatic damage in psoriasis patients. The British journal of dermatology, 1996, Volume: 134, Issue:3 Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Immunosuppressive Agents; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Peptide Fragments; Procollagen; Prospective Studies; Psoriasis; Radionuclide Imaging	1996
Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective, multicenter analysis. Bone marrow transplantation, 1996, Volume: 18, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Ciprofloxacin; Cyclophosphamide; Estrogens; Female; Genetic Diseases, Inborn; Graft vs Host Disease; Hepatic Veno-Occlusive Disease; Humans; Immunosuppressive Agents; Incidence; Life Tables; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Multiple Organ Failure; Multivariate Analysis; Neoplasms; Progestins; Retrospective Studies; Risk Factors; Transplantation Conditioning; Vancomycin	1996
Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:4 Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Liver Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transaminases; Treatment Outcome	1997
Re: J.M. Kremer--editorial. The American journal of gastroenterology, 1997, Volume: 92, Issue:8 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Practice Guidelines as Topic	1997
Nicotinamide and methionine reduce the liver toxic effect of methotrexate. General pharmacology, 1999, Volume: 33, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Liver Diseases; Male; Methionine; Methotrexate; Mice; Mice, Inbred DBA; Niacinamide	1999
The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents. Oncogene, 2000, Jul-20, Volume: 19, Issue:31 Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; bcl-2-Associated X Protein; Binding Sites; Body Weight; Cell Line, Transformed; Crosses, Genetic; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Progression; DNA; DNA Damage; Doxorubicin; Gamma Rays; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p53; Genotype; Hyperplasia; Liver; Liver Diseases; Liver Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nuclear Proteins; Organ Size; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Simian virus 40; Tumor Suppressor Protein p53; Ultraviolet Rays	2000
Liver biopsies and methotrexate: a time for reconsideration? Journal of the American Academy of Dermatology, 2001, Volume: 44, Issue:5 Topics: Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Practice Guidelines as Topic; Psoriasis	2001
Methotrexate poisoning with acute hepatorenal dysfunction. Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:1 Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Hemofiltration; Humans; Liver Diseases; Methotrexate; Osteosarcoma; Plasma Exchange; Renal Dialysis; Treatment Outcome	2001
Liver biopsy in methotrexate-treated psoriatics-a re-evalution. Acta dermato-venereologica, 1975, Volume: 55, Issue:4 Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Child; Ethanol; Female; Follow-Up Studies; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis	1975
Hepatotoxicity in the treatment of acute lymphoblastic leukaemia. Medical and pediatric oncology, 1979, Volume: 7, Issue:4 Topics: Adolescent; Antineoplastic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Child; Humans; Leukemia, Lymphoid; Liver Diseases; Liver Function Tests; Mercaptopurine; Methotrexate	1979
Enzymatic fluorometry for estimating serum total bile acid concentration. JAMA, 1979, May-11, Volume: 241, Issue:19 Topics: 3-Hydroxysteroid Dehydrogenases; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Fasting; Fatty Liver; Female; Fluorometry; Hepatitis, Viral, Human; Humans; Liver; Liver Diseases; Male; Methotrexate; Necrosis; Sarcoidosis	1979
Choline antagonism of methotrexate liver toxicity in the rat. Medical and pediatric oncology, 1977, Volume: 3, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Hydroxyurea; Liver; Liver Diseases; Male; Methotrexate; Methylation; Rats; Triglycerides	1977
Liver biopsies from psoriatics related to methotrexate therapy. 1. Findings in 123 consecutive non-methotrexate treated patients. Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1976, Volume: 84, Issue:3 Topics: Adult; Age Factors; Aged; Alcohol Drinking; Aspartate Aminotransferases; Body Weight; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis	1976
Liver biopsies from psoriatics related to methotrexate therapy. 2. Findings before and after methotexate therapy in 88 patients. A blind study. Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1976, Volume: 84, Issue:3 Topics: Adult; Age Factors; Aged; Alcohol Drinking; Aspartate Aminotransferases; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis	1976
Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy. Acta dermato-venereologica, 1992, Volume: 72, Issue:5 Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Female; Follow-Up Studies; Humans; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis	1992
Fulminant hepatic failure in non-Hodgkin lymphoma patients treated with chemotherapy. European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:8-9 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Doxorubicin; Female; Hepatitis B; Humans; Immunocompromised Host; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisolone; Prednisone; Vincristine	1992
Massive intrahepatic hemorrhage following routine liver biopsy in a patient with rheumatoid arthritis treated with methotrexate. The Journal of rheumatology, 1992, Volume: 19, Issue:9 Topics: Adult; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Liver; Liver Diseases; Methotrexate	1992
Liver biopsy versus ultrasound in methotrexate-treated psoriasis: a decision analysis. International journal of dermatology, 1992, Volume: 31, Issue:6 Topics: Algorithms; Biopsy; Decision Support Techniques; Humans; Liver; Liver Diseases; Methotrexate; Psoriasis; Ultrasonography	1992
Clinical liver disease in patients with rheumatoid arthritis taking methotrexate. The Journal of rheumatology, 1992, Volume: 19, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Humans; Incidence; Liver; Liver Cirrhosis; Liver Diseases; Methotrexate; Middle Aged; Obesity; Pulmonary Fibrosis	1992
A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment. Blood, 1990, Oct-15, Volume: 76, Issue:8 Topics: Antibodies, Monoclonal; Antilymphocyte Serum; Bone Marrow Transplantation; Cyclosporins; Glucocorticoids; Graft vs Host Disease; Humans; Intestinal Diseases; Liver Diseases; Methotrexate; Multivariate Analysis; Retrospective Studies; Skin Diseases	1990
Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia. British journal of cancer, 1990, Volume: 61, Issue:5 Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Liver Diseases; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transaminases	1990
Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate. Arthritis and rheumatism, 1990, Volume: 33, Issue:7 Topics: Arthritis, Rheumatoid; Female; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Methotrexate; Middle Aged; Necrosis	1990
Chronic liver diseases: current therapeutic options. Hospital practice (Office ed.), 1989, Mar-15, Volume: 24, Issue:3 Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Cholangitis, Sclerosing; Chronic Disease; Colchicine; Diagnosis, Differential; Drug Therapy, Combination; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Interferon Type I; Liver Cirrhosis, Biliary; Liver Diseases; Methotrexate	1989
Revised guidelines on methotrexate use and liver biopsy. The American journal of gastroenterology, 1989, Volume: 84, Issue:7 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Time Factors	1989
Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-term bolus methotrexate. Arthritis and rheumatism, 1988, Volume: 31, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Time Factors	1988
Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis. Arthritis and rheumatism, 1988, Volume: 31, Issue:12 Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Collagen; Female; Humans; Liver; Liver Diseases; Lysosomes; Male; Methotrexate; Microscopy; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Prospective Studies	1988
The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate. The British journal of dermatology, 1988, Volume: 119, Issue:6 Topics: Adult; Antipyrine; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Psoriasis; Saliva	1988
Sarcoidosis. Usual and unusual manifestations. Chest, 1988, Volume: 94, Issue:1 Topics: Anemia; Female; Humans; Hypercalcemia; Liver Diseases; Lung Diseases; Methotrexate; Middle Aged; Prednisone; Sarcoidosis; Skin Diseases	1988
A patient with methotrexate lung and granulomatous changes in the liver--or just sarcoidosis? International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:6 Topics: Blood Gas Analysis; Body Temperature; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Granuloma; Humans; Liver; Liver Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Radiography; Respiratory Function Tests; Sarcoidosis	1988
[Clinical effect of prostaglandin E1 on liver dysfunction due to high-dose methotrexate]. Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:2 Topics: Alprostadil; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Osteosarcoma	1988
Acute and chronic graft-versus-host disease: clinical manifestations, prophylaxis, and treatment. Journal of the National Cancer Institute, 1986, Volume: 76, Issue:6 Topics: Acute Disease; Age Factors; Animals; Chronic Disease; Cyclosporins; Dogs; Glucocorticoids; Graft vs Host Disease; Humans; Infections; Intestinal Diseases; Liver Diseases; Methotrexate; Risk; Skin Diseases	1986
Diffuse hepatic uptake of technetium-99m methylene diphosphonate in a patient receiving high dose methotrexate. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1987, Volume: 28, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Liver Diseases; Methotrexate; Radionuclide Imaging; Technetium Tc 99m Medronate	1987
The aminopyrine breath test, an inadequate early indicator of methotrexate-induced liver disease in patients with psoriasis. Clinical and investigative medicine. Medecine clinique et experimentale, 1987, Volume: 10, Issue:2 Topics: Aminopyrine; Breath Tests; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methotrexate; Psoriasis	1987
Hepatotoxicity associated with low-dose, long-term methotrexate treatment of rheumatoid arthritis. Scandinavian journal of rheumatology, 1987, Volume: 16, Issue:4 Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Time Factors	1987
Long-term effects of etretinate on the liver in psoriasis. The American journal of surgical pathology, 1987, Volume: 11, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Etretinate; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis	1987
Methotrexate and the liver. The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12 Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Necrosis; Serum Albumin; Transaminases	1985
Ultrasound as a screening procedure for methotrexate-induced hepatic damage in severe psoriasis. The British journal of dermatology, 1985, Volume: 113, Issue:6 Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Ultrasonography	1985
Low incidence of hepatotoxicity associated with long-term, low-dose oral methotrexate in treatment of refractory psoriasis, psoriatic arthritis, and rheumatoid arthritis. An acceptable risk/benefit ratio. Digestive diseases and sciences, 1985, Volume: 30, Issue:2 Topics: Adult; Aged; Alcohol Drinking; Arthritis; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis	1985
Methotrexate maintenance therapy and liver damage in psoriasis. Clinical and experimental dermatology, 1985, Volume: 10, Issue:3 Topics: Adult; Age Factors; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis	1985
Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes. Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:4 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors	1985
Low-dose methotrexate treatment of rheumatoid arthritis. Long-term observations. The American journal of medicine, 1985, Volume: 79, Issue:3 Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Transaminases	1985
[Liver damage due to cytostatic agents]. Bratislavske lekarske listy, 1985, Volume: 83, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Dexamethasone; Humans; Liver; Liver Diseases; Male; Mercaptopurine; Methotrexate; Prednisone	1985
Liver biopsy in methotrexate treatment. Acta dermato-venereologica, 1971, Volume: 51, Issue:3 Topics: Adult; Aged; Alanine Transaminase; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Necrosis; Pityriasis; Pityriasis Rubra Pilaris; Psoriasis	1971
[Liver biopsy studies in long-term therapy of psoriasis using methotrexate]. Dermatologische Monatschrift, 1974, Volume: 160, Issue:8 Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Long-Term Care; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors	1974
Liver disease in psoriatics--An effect of methotrexate therapy? Archives of dermatology, 1974, Volume: 110, Issue:4 Topics: Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Cell Nucleus; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methods; Methotrexate; Mitochondria, Liver; Psoriasis; Sulfobromophthalein; Time Factors	1974
Hepatotoxicity of methotrexate in the treatment of psoriasis. The Practitioner, 1973, Volume: 211, Issue:263 Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methotrexate; Middle Aged; Psoriasis; Time Factors	1973
Life-span carcinogenicity tests with 4-amino-N10-methylpteroylglutamic acid (methotrexate) in Swiss mice and Syrian golden hamsters. Toxicology and applied pharmacology, 1973, Volume: 26, Issue:3 Topics: Age Factors; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Cricetinae; Female; Liver; Liver Diseases; Lung Neoplasms; Lymphoma; Male; Methotrexate; Mice; Sex Factors; Species Specificity; Time Factors	1973
Hepatotoxicity of long-term methotrexate therapy for psoriasis. Archives of internal medicine, 1973, Volume: 132, Issue:3 Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Necrosis; Psoriasis; Time Factors	1973
Liver biopsy in psoriasis. The British journal of dermatology, 1970, Volume: 82, Issue:3 Topics: Adult; Aged; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis; Transaminases	1970
Fibrinolytic bleeding complicated by factor 13 defect. Archives of internal medicine, 1968, Volume: 121, Issue:6 Topics: Aminocaproates; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Factor XIII; Female; Fibrinolysis; Hemorrhage; Humans; Liver Diseases; Male; Methotrexate; Middle Aged	1968
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. 3. Plasma clearance in man and organ distribution in rat following intravenous administration of tritiated folic acid. The Journal of vitaminology, 1968, Mar-10, Volume: 14, Issue:1 Topics: Acute Disease; Animals; Body Weight; Bone Marrow; Carbon Tetrachloride; Chronic Disease; Folic Acid; Hematologic Diseases; Humans; Injections, Intravenous; Kidney; Leukemia; Liver; Liver Diseases; Methotrexate; Rats; Spleen; Tritium	1968
Hepatic fibrosis in a child possibly due to prolonged methotrexate. Journal of clinical pathology, 1966, Volume: 19, Issue:1 Topics: Child; Female; Humans; Leukemia; Liver Diseases; Methotrexate	1966