methotrexate has been researched along with Leukemia P388 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (41.67) | 18.7374 |
| 1990's | 17 (47.22) | 18.2507 |
| 2000's | 2 (5.56) | 29.6817 |
| 2010's | 2 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaumont, Y; Kisliuk, RL; McCaleb, GS; Montgomery, JA; Piper, JR; Sirotnak, FM | 1 |
| Iijima, A; Kitoh, K; Kotake, Y; Koyanagi, N; Nomura, H; Ozawa, Y; Tamai, N; Yoshimatsu, K | 1 |
| Barrero, AF; Cabrera, E; Chahboun, R; Cortés, M; Lara, M; Manzaneda, EA; Rivas, AR | 1 |
| Allaiarova, UIu; Cherniak, AV; Goncharova, SA; Iakushchenko, TN; Klimanova, EN; Konovalova, NP; Mishchenko, DV; Raevskaia, TA; Sashenkova, TE; Vystoron, IV | 1 |
| Boratyński, J; Goszczyński, T; Nevozhay, D; Omar, MS; Wietrzyk, J | 1 |
| Boratynski, J; Budzynska, R; Jagiello, M; Kanska, U; Nevozhay, D; Opolski, A; Wietrzyk, J | 1 |
| Fabre, G; Fabre, I; Goldman, ID | 1 |
| Corbett, TH; Griswold, DP; Laster, WR; Schabel, FM; Skipper, HE; Trader, MW | 1 |
| Mabel, JA; Wodinsky, I | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH; Uitendaal, MP | 1 |
| Ambaye, RY; Gokhale, SV; Parchure, M | 1 |
| Hoots, WK; Nelson, JA | 1 |
| Palmer, S; Panasci, L; Polizzi, G | 1 |
| Fuska, J; Fusková, A; Proksa, B | 1 |
| Iijima, A; Kotake, Y; Nomura, H; Okauchi, T; Yoshimatsu, K | 1 |
| Bachrach, U; Marom, Y; Ramu, A; Ramu, N; Shayovitz, A | 1 |
| Hirano, S; Iguchi, H; Izumi, H; Matsushita, Y; Takeuchi, T; Tone, H | 1 |
| Elliott, WL; Howard, CT; Leopold, WR; Roberts, BJ | 1 |
| Góra-Tybor, J; Robak, T | 1 |
| Abraham, A; Galivan, J; Kisliuk, RL; McGuire, JJ; Nair, MG; Vishnuvajjala, BR | 1 |
| Hagiwara, A; Hoshima, M; Imanishi, T; Muranishi, S; Ohgaki, M; Ohyama, T; Sakakura, C; Sawai, K; Takahashi, T; Yamamoto, A | 1 |
| Sugimura, K; Sukemori, S | 1 |
| Boratyński, J; Górski, A; Opolski, A; Radzikowski, C; Wietrzyk, J | 1 |
| Fujikura, R; Inaba, M; Sakurai, Y | 1 |
| Fletcher, WS; Milo, G; Pommier, RF; Woltering, EA | 1 |
| Hagiwara, A; Okano, S; Ozaki, K; Sakakura, C; Sasaki, S; Sawai, K; Shimotsuma, M; Shirasu, M; Takahashi, T; Tsujimoto, H | 1 |
| Robak, T; Warzocha, K | 1 |
| Cao, S; Wu, S; Xue, Y; Zhen, Y | 1 |
| Aschele, C; Bertino, JR; Nicolin, A; Rosso, R; Sobrero, A | 1 |
| Czyzewska-Szafran, H; Danysz, A; Jastrzebski, Z; Jedrych, A; Sołtysiak-Pawluczuk, D | 1 |
| Brusentsov, NA; Glazkova, TIu; Iavorskaia, NP; Iurchenko, NIa | 1 |
| Besserer, JA; Fry, DW; Klohs, WD; Steinkampf, RW | 1 |
| Mandelbaum-Shavit, F; Ramu, A | 1 |
| Hoshino, A; Ito, Y; Machida, S | 1 |
| Akiyama, S; Komiyama, S; Kuwano, M; Nakagawa, M; Ogata, J; Shiraishi, N; Ueda, H; Yamaguchi, T | 1 |
| Fridkin, M; Ramu, A; Steinherz, R | 1 |
1 review(s) available for methotrexate and Leukemia P388
| Article | Year |
|---|---|
Establishment of cross-resistance profiles for new agents.
Topics: Animals; Antineoplastic Agents; Cell Line; Doxorubicin; Drug Resistance; Humans; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Methotrexate; Phenotype; Vincristine | 1983 |
35 other study(ies) available for methotrexate and Leukemia P388
| Article | Year |
|---|---|
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Topics: Aminopterin; Animals; Bacteria; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Polyglutamic Acid; Structure-Activity Relationship | 1986 |
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Colonic Neoplasms; Folic Acid Antagonists; Glutamates; Humans; Leukemia P388; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol.
Topics: Animals; Antineoplastic Agents; Benzofurans; Diterpenes; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Naphthalenes; Porifera; Sesquiterpenes; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
[Cyclic hydroxamic acids as chemosensitizers in cytostatic therapy].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Hydroxamic Acids; Leukemia P388; Methotrexate; Neoplasms, Experimental | 2013 |
The antileukemic activity of modified fibrinogen-methotrexate conjugate.
Topics: Animals; Antimetabolites, Antineoplastic; Cattle; Cell Survival; Drug Carriers; Fibrinogen; Leukemia P388; Male; Methotrexate; Mice; Survival Analysis; Tumor Cells, Cultured | 2013 |
Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Humans; Leukemia P388; Mannans; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 2007 |
Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.
Topics: Animals; Cell Line; Cell Survival; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; Kinetics; Leukemia P388; Leukemia, Myeloid, Acute; Methotrexate; Mice; Peptides; Polyglutamic Acid; Protein Binding | 1984 |
Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Leukemia P388; Melanoma; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Mitomycins; Neoplasms, Experimental | 1983 |
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1984 |
Combination of anticancer agents with folic acid in the treatment of murine leukaemia P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Folic Acid; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mitomycins | 1984 |
Treatment of murine testicular leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Leukemia P388; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred DBA; Testicular Neoplasms; Vincristine | 1984 |
Diminished toxicity of methotrexate in CD2F1 mice pretreated with cycloheximide.
Topics: Animals; Cycloheximide; Injections, Intraperitoneal; Lethal Dose 50; Leukemia P388; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Protein Biosynthesis; Time Factors | 1982 |
7,8-dihydro-5H-isoindolo[1,2-b] [3]benzazepine-5-ones. Part 2: In vitro effect of derivatives substituted at position 7 on leukemia P 388 cells.
Topics: Animals; Antineoplastic Agents; Benzazepines; Cell Division; Chemical Phenomena; Chemistry; Drug Synergism; In Vitro Techniques; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Proteins; Structure-Activity Relationship; Time Factors; Uridine | 1982 |
Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate.
Topics: Animals; Cell Division; Colorectal Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; KB Cells; Leukemia P388; Methotrexate; Pyridines; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Ornithine decarboxylase--a predictor for tumor chemosensitivity.
Topics: Animals; Biomarkers; Cell Division; Doxorubicin; Drug Resistance; Humans; Leukemia P388; Methotrexate; Mice; Ornithine Decarboxylase; Tumor Cells, Cultured; Vinblastine | 1994 |
Experimental combination chemotherapy of pirarubicin with various antitumor drugs against P388 murine leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Screening Assays, Antitumor; Fluorouracil; Leukemia P388; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Peplomycin; Vindesine | 1994 |
Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Screening Assays, Antitumor; Etoposide; Ifosfamide; Leukemia P388; Mammary Neoplasms, Animal; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Sarcoma, Experimental; Vinblastine | 1994 |
Synergistic action of 2-chlorodeoxyadenosine and cyclophosphamide on murine leukemias L1210 and P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Drug Synergism; Female; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred DBA | 1993 |
Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase.
Topics: Aminopterin; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred Strains; Tumor Cells, Cultured | 1993 |
Methotrexate bound to carbon particles used for treating cancers with lymph node metastases in animal experiments and a clinical pilot study.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carbon; Digestive System Neoplasms; Dosage Forms; Humans; Leukemia P388; Lymphatic Metastasis; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Pilot Projects; Rats; Rats, Inbred Strains | 1996 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Cytotoxic and antitumor effect of fibrinogen-methotrexate conjugate.
Topics: Animals; Antineoplastic Agents; Fibrinogen; Humans; Immunotoxins; Inhibitory Concentration 50; Injections, Intraperitoneal; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Solubility; Tumor Cells, Cultured | 2000 |
Comparative study of in vivo development of resistance to various classes of antitumor agents in P388 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance; Female; Fluorouracil; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation | 1979 |
Synergistic cytotoxicity of combinations of dimethyl sulfoxide and antineoplastic agents against P388 leukemia in CD-F1 mice.
Topics: Animals; Antineoplastic Agents; Cell Survival; Dimethyl Sulfoxide; Drug Synergism; Leukemia P388; Methotrexate; Mice; Mice, Inbred Strains; Mitoxantrone; Tumor Cells, Cultured | 1992 |
[Cancer chemotherapy for lymph nodal metastases using activated carbon particles adsorbing methotrexate].
Topics: Animals; Carbon; Injections, Intralesional; Leukemia P388; Lymph Nodes; Lymphatic Metastasis; Methotrexate; Mice; Mice, Inbred DBA | 1992 |
Antileukemic effects of recombinant human tumor necrosis factor alpha (rh-TNF alpha) with cyclophosphamide or methotrexate on leukemia L1210 and leukemia P388 in mice.
Topics: Animals; Combined Modality Therapy; Cyclophosphamide; Drug Evaluation, Preclinical; Female; Humans; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Recombinant Proteins; Time Factors; Tumor Necrosis Factor-alpha | 1992 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Plant Extracts; Tea; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1991 |
Rapid development of resistance to antifolates in vitro: possible clinical implication.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1991 |
Effect of solcoseryl on antitumour action and acute toxicity of some antineoplastic drugs.
Topics: Actihaemyl; Animals; Antineoplastic Agents; Cytarabine; Drug Interactions; Fluorouracil; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Mitoxantrone | 1991 |
[Antineoplastic activity of combinations of cytostatics and dextran-ferrite administered to mice with leukemia P-388].
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Dactinomycin; Daunorubicin; Doxorubicin; Drug Combinations; Fluorouracil; Iron-Dextran Complex; Leukemia P388; Melphalan; Methotrexate; Mice; Tegafur | 1990 |
Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Pyrimidines; Quinazolines; Trimetrexate | 1986 |
Dihydrofolate reductase activity in adriamycin and methotrexate sensitive and resistant P388 leukemia cells.
Topics: Animals; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1987 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Mitomycin; Mitomycins; Nitrosourea Compounds; Thioguanine | 1985 |
Potentiation by vitamin A of the action of anticancer agents against murine tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diterpenes; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Leukemia P388; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Nimustine; Nitrosourea Compounds; Retinyl Esters; Sarcoma 180; Vitamin A | 1985 |
Cross resistance to esters of methotrexate in a doxorubicin-resistant subline of P388 murine leukemia.
Topics: Animals; Cell Survival; Cells, Cultured; Doxorubicin; Drug Resistance; Esterification; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice | 1985 |