methotrexate has been researched along with Leukemia L5178 in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (96.15) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Li, R; Selassie, CD | 1 |
| Dedhar, S; Goldie, JH | 1 |
| Bellamy, AS; Hill, BT | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Berchtold, W; Bürki, H; Laissue, JA | 1 |
| Lokiec, F; Najean, Y; Poirier, O | 1 |
| Dedhar, S; Freisheim, JH; Goldie, JH; Hynes, JB | 2 |
| Barsoum, J; Levinger, L; Varshavsky, A | 1 |
| Bertino, JR; Dube, S; Kamen, BA; Scheer, DI; Srimatkandada, S | 1 |
| Dedhar, S; Goldie, JH; Hill, BT | 1 |
| Bertino, JR; Kamen, BA | 1 |
| Capizzi, RL | 1 |
| Capizzi, RL; Keefe, DA; Rudnick, SA | 1 |
| Ito, A; Nakamura, N; Okada, S; Suzuki, S | 1 |
| Dedhar, S; Goldie, JH; Gudauskas, G; Hartley, D; Krystal, G | 1 |
| Nakamura, N; Okada, S | 1 |
| Dedhar, S; Goldie, JH; Krystal, G | 1 |
| Bertino, JR; Dolnick, BJ | 1 |
| Aherne, GW; Boyle, FT; Brunton, L; Jackman, AL; Jansen, G; Kimbell, R; Smith, MN; Stephens, TC; Wardleworth, JM | 1 |
| Hryniuk, WM; Kreml, JA; Yamada, EW | 1 |
| Goldie, JH; Hill, BT | 1 |
| Capizzi, RL; Fernandes, DJ; Kute, TE; Sur, P | 1 |
| Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG | 1 |
| Gołos, B; Malec, J | 1 |
1 review(s) available for methotrexate and Leukemia L5178
| Article | Year |
|---|---|
Folate and anti-folate transport in mammalian cells.
Topics: Animals; Biological Transport; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Leukemia L5178; Liver Neoplasms, Experimental; Methotrexate; Neoplasms, Experimental | 1980 |
1 trial(s) available for methotrexate and Leukemia L5178
| Article | Year |
|---|---|
Asparaginase-methotrexate in combination chemotherapy: schedule-dependent differential effects on normal versus neoplastic cells.
Topics: Adult; Animals; Asparaginase; Cells, Cultured; Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia L5178; Leukemia, Lymphoid; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors | 1981 |
24 other study(ies) available for methotrexate and Leukemia L5178
| Article | Year |
|---|---|
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Pyrimidines; Solubility | 1982 |
Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line.
Topics: Animals; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Isoenzymes; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1983 |
Murine L5178Y cells resulting in altered drug sensitivities from fractionated radiation exposure in vitro.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Hydroxyurea; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Vincristine | 1984 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Survival of tumor-bearing mice exposed to heavy water or heavy water plus methotrexate.
Topics: Animals; Cell Line; Deuterium; Female; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasm Transplantation; Probability; Sarcoma, Experimental; Time Factors | 1982 |
[Enhancement by sodium butyrate of the cytotoxic effect of methotrexate on leukemic cells].
Topics: Animals; Butyrates; Butyric Acid; Cell Division; Drug Synergism; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice | 1982 |
Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines.
Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Quinazolines; Triazines | 1983 |
On the chromatin structure of the amplified, transcriptionally active gene for dihydrofolate reductase in mouse cells.
Topics: Animals; Cells, Cultured; Chromatin; Cloning, Molecular; DNA; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Genes; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Nucleic Acid Hybridization; Nucleosomes; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 1982 |
Organization of the methotrexate resistant mouse L5178YR dihydrofolate reductase gene and transformation of human HCT-8 cells by this gene.
Topics: Animals; Base Sequence; Cell Line; Colonic Neoplasms; Drug Resistance; Gene Amplification; Genes, Regulator; Genetic Engineering; Humans; Leukemia L5178; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Transformation, Genetic | 1981 |
Preliminary communications.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Resistance; Leucovorin; Leukemia L5178; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Time Factors | 1982 |
Methotrexate cytotoxicity for L5178Y/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Administration Schedule; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Models, Biological; Time Factors | 1982 |
Mutations induced by gamma-rays and fast neutrons in cultured mammalian cells. Differences in dose response and RBE with methotrexate-and 6-thioguanine-resistant systems.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Drug Resistance; Fast Neutrons; Gamma Rays; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Mutation; Thioguanine | 1982 |
A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells.
Topics: Animals; Cell Line; Cell Survival; Chromatography, Affinity; Chromatography, High Pressure Liquid; Drug Resistance; Folic Acid Antagonists; Genetic Variation; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1980 |
Dose-rate effects of gamma-ray-induced mutations in cultured mammalian cells.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Drug Resistance; Gamma Rays; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Mutation; Thioguanine | 1981 |
Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells.
Topics: Animals; Drug Resistance; Genetic Variation; Isoenzymes; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Molecular Weight; Tetrahydrofolate Dehydrogenase | 1981 |
Multiple messenger RNAs for dihydrofolate reductase.
Topics: Animals; Cloning, Molecular; Drug Resistance; Leukemia L5178; Methotrexate; Mice; Nucleic Acid Hybridization; Protein Biosynthesis; RNA, Messenger; Tetrahydrofolate Dehydrogenase | 1981 |
Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Female; Humans; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
Effect of methotrexate on cyclic AMP levels in cultured L5178Y cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic AMP; Hypoxanthines; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Time Factors | 1979 |
An apparent relationship between responsiveness to folinic acid protection from methotrexate cytotoxicity and uptake of 5-methyltetrahydrofolate in a series of murine cell lines.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolates | 1979 |
Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
Topics: Animals; Cell Division; Cell Survival; Hydrolysis; Leukemia L5178; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Polyglutamic Acid; Thymidylate Synthase | 1988 |
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1985 |
Enhancement of methotrexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178Y cells by the reduction of DNA repair efficiency.
Topics: Animals; Caffeine; Cell Division; Cell Survival; DNA; DNA Damage; DNA Repair; Drug Synergism; In Vitro Techniques; Leukemia L5178; Methotrexate; Mice; Tumor Cells, Cultured | 1989 |
Further studies on substituted quinazolines and triazines as inhibitors of a methotrexate-insensitive murine dihydrofolate reductase.
Topics: Animals; Cell Line; Chemical Phenomena; Chemistry; Leukemia L5178; Methotrexate; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Triazines | 1986 |