methotrexate has been researched along with Leukemia L 1210 in 607 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 495 (81.55) | 18.7374 |
| 1990's | 93 (15.32) | 18.2507 |
| 2000's | 13 (2.14) | 29.6817 |
| 2010's | 6 (0.99) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaykovsky, M; Gaumont, Y; Gittelman, MC; Kisliuk, RL; Martinelli, JE | 1 |
| Chaykovsky, M; Gaumont, Y; Kisliuk, RL; Martinelli, JE | 1 |
| Rosowsky, A; Yu, CS | 2 |
| Ensminger, WD; Lazarus, H; Rosowsky, A; Yu, CS | 1 |
| Chaykovsky, M; Hirst, M; Lazarus, H; Martinelli, JE | 1 |
| Elliott, RD; Montgomery, JA; Piper, JR; Roberts, EC; Shealy, YF; Temple, C | 1 |
| Colvin, PL; Eason, DE; Garrett, CM; Hynes, JB | 1 |
| Hynes, JB; Oatis, JE | 1 |
| Barredo, J; Grindey, GB; Jannatipour, M; Kuhnt, D; Moran, RG; Rinzel, SM; Shih, C; Taylor, EC | 1 |
| Johnson, CA; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Baraldi, PG; Bazzanini, R; Guarneri, M; La Colla, P; Manfredini, S; Marongiu, ME; Pani, A; Simoni, D; Tramontano, E | 1 |
| Christie, PH; Colwell, WT; DeGraw, JI; Sirotnak, FM | 1 |
| Galivan, J; Malik, ND; Piper, JR; Rhee, MS; Sirotnak, FM | 1 |
| Bader, H; Freisheim, JH; Rosowsky, A | 2 |
| Forsch, RA; Moran, RG; Rosowsky, A | 1 |
| Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM | 2 |
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| Gaumont, Y; Kisliuk, RL; McCaleb, GS; Montgomery, JA; Piper, JR; Sirotnak, FM | 2 |
| Danenberg, PV; Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Wick, MM | 1 |
| Duch, DS; Edelstein, MP; Ferone, R; Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Patil, SD; Thorndike, J | 1 |
| Cole, A; Freisheim, JH; Hagan, RL; Hynes, JB; Kohler, W; Patil, SA | 1 |
| Bader, H; Freisheim, JH; Moran, RG; Radike-Smith, M; Rosowsky, A; Solan, VC; Wright, JE | 1 |
| Bader, H; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Gaumont, Y; Hsiao, MC; Kalman, TI; Kisliuk, RL; Nair, IG; Nair, MG; Nanavati, NT | 1 |
| Colwell, WT; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM | 1 |
| Gaumont, Y; Ghazala, M; Kalman, TI; Kisliuk, RL; Nair, MG; Toghiyani, TR | 1 |
| Baccanari, DP; Delcamp, TJ; Forsch, RA; Freisheim, JH; Rosowsky, A; Solan, VC | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sato, M; Sirotnak, FM; Thorndike, J | 1 |
| Gaumont, Y; Kisliuk, RL; McCaleb, GS; Montgomery, JA; Piper, JR; Sirotnak, FM; Thorndike, J | 1 |
| Bader, H; Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A | 1 |
| Bader, H; Cucchi, CA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Bader, H; Cucchi, CA; Freisheim, JH; Radike-Smith, M; Rosowsky, A; Wick, MM | 1 |
| Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Schmid, FA; Sirotnak, FM; Tagawa, H | 1 |
| Bader, H; Cucchi, CA; Forsch, RA; Frei, E; Freisheim, JH; Rosowsky, A; Susten, SS | 1 |
| Farrington, M; Floyd, GG; Freisheim, JH; Gale, GR; Harmon, SJ; Hart, LD; Hynes, JB; Susten, SS; Washtien, WL | 1 |
| Beardsley, GP; Fletcher, SR; Harrington, PJ; Moran, RG; Taylor, EC | 1 |
| McCaleb, GS; Montgomery, JA; Piper, JR; Schmid, FA; Sirotnak, FM | 1 |
| Forsch, R; Freisheim, JH; Kumar, AA; Rosowsky, A; Uren, J; Wick, M | 1 |
| Henkin, J; Washtien, WL | 1 |
| Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Wick, M | 1 |
| Brown, EG; Christie, PH; DeGraw, JI; Gaumont, Y; Kelly, LF; Kisliuk, RL; Sirotnak, FM | 1 |
| Forsch, RA; Freisheim, JH; Galivan, J; Rosowsky, A; Wick, M | 1 |
| Chen, SY; Gaumont, Y; Kisliuk, RL; Nair, MG; Strumpf, D | 1 |
| Bridges, TW; Gaumont, Y; Henkel, TJ; Kisliuk, RL; Nair, MG; Sirotnak, FM | 1 |
| Forsch, R; Rosowsky, A; Uren, J; Wick, M | 1 |
| Forsch, R; Rosowsky, A | 1 |
| Chello, PL; Montgomery, JA; Piper, JR; Sirotnak, FM | 2 |
| Brown, VH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Tagawa, H | 1 |
| Bussolari, JC; Chen, SF; Panzica, RP; Ramesh, K; Stoeckler, JD | 1 |
| Johnson, CA; Maddry, JA; Malik, ND; McGuire, JJ; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM | 1 |
| Kalman, TI; Mao, Z; Pan, J | 1 |
| Bavetsias, V; Boyle, FT; Jackman, AL; Kimbell, R; Marriott, JH; Matusiak, ZS; Melin, C | 1 |
| Gorges, J; Höhn, M; Kazmaier, U; Kern, S; Truebenbach, I; Vollmar, AM; Wagner, E; Zahler, S | 1 |
| Gorges, J; Höhn, M; Kazmaier, U; Kern, S; Loy, DM; Truebenbach, I; Wagner, E | 1 |
| Agbenowu, S; Bearden, SE; Bhushan, A; Cao, S; Daniels, CK; Lai, JCK; Li, M; Liu, T; Rios, Z; Sheridan, PP; Singh, R | 1 |
| Hu, YB; Shao, LB; Shen, Y; Wang, YQ; Wu, K; Zhao, L | 1 |
| Bartier, WA; Chong, L; Ma, G; Tattersall, MH | 1 |
| Goldin, A; Kline, I; Mantel, N; Venditti, JM | 1 |
| Ashwini, S; Bhushan, A; Cao, S; Daniels, CK; Dean, A; Lai, JC; Liu, T; Sheridan, PP | 1 |
| Gao, F; Goldman, ID; Wang, Y; Zhao, R | 1 |
| GOLDIN, A; KLINE, I; VENDITTI, JM | 1 |
| GOLDIN, A; SHELDON, DR; VENDITTI, JM | 2 |
| BIANCO, AR; GLYNN, JP; GOLDIN, A; HUMPHREYS, SR; TRIVERS, G | 1 |
| BIEDLER, JL; GREENBERG, NH; HUTCHISON, DJ; ROBINSON, DL; SCHRECKER, AW; VENDITTI, JM | 1 |
| BIEDLER, JL; HUTCHISON, DJ; SCHRECKER, AW | 1 |
| MISRA, DK | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| BENJAMIN, W; GELLHORN, A; KOREN, Z; RECHLER, M; WAGNER, M | 1 |
| CHIRIGOS, MA; GLYNN, JP; GOLDIN, A; HUMPHREYS, SR; THOMAS, LB | 1 |
| BURCHENAL, JH; LYMAN, M; OETTGEN, HF; PURPLE, J | 1 |
| CUTTS, JH | 1 |
| HUENNEKENS, FM; SCHRECKER, AW | 1 |
| RUTMAN, RJ | 1 |
| GOLDIN, A; VENDITTI, JM | 2 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD; MUSSER, EA | 1 |
| BRINDLE, SD; HIRSCHBERG, E; SEMENTE, G | 1 |
| ALBRECHT, AM; BIEDLER, JL; HUTCHISON, DJ | 1 |
| KRIVIT, W; LOTTSFELDT, FI; PEHOUSHEK, C | 1 |
| GREENBERG, NH; MEAD, JA; SCHRECKER, AW; SEEGER, DR; TOMCUFCIK, AS | 1 |
| Bilyy, RO; Stoika, RS | 1 |
| Cory, AH; Cory, JG | 1 |
| Jiang, F; Wei, DZ; Zhang, JF; Zhou, X | 1 |
| Johnson, RE | 1 |
| Wilcox, WS | 1 |
| Pine, MJ | 1 |
| Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D | 1 |
| Hall, TC; Kessel, D | 1 |
| Mhatre, RM; Saslaw, LD; Waravdekar, VS | 1 |
| Burdeshaw, JA; Dixon, GJ; Dulmadge, EA; Wilcox, WS; Wilkoff, LJ | 1 |
| Skipper, HE | 2 |
| Afonin, NI; Ermakova, LN; Oksinoĭd, OE | 1 |
| Buesa, JM | 1 |
| Chu, BC; Whiteley, JM | 2 |
| Chello, PL; Poser, RG; Sirotnak, F | 1 |
| Bertino, JR; Fernandes, DJ | 1 |
| Benz, C; Cadman, E | 1 |
| Benz, C; Cadman, E; Heimer, R | 1 |
| Cesario, T; Slater, LM; Wetzel, MW | 1 |
| Iqbal, MP; Rothenberg, SP | 2 |
| Chello, PL; Poser, RG; Sirotnak, FM | 1 |
| Bertino, JR; Fernandes, DJ; Moroson, BA | 1 |
| Lankelma, J; Leyva, A; Nederbragt, H; Pinedo, HM | 1 |
| Poser, RG; Sirotnak, FM | 1 |
| Bertino, J; Cashmore, A; Eibl, B; Kamen, BA | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Midoux, P; Monsigny, M; Roche, AC | 1 |
| Buesa-Perez, JM; Leyva, A; Pinedo, HM | 1 |
| Henderson, GB; Zevely, EM | 10 |
| Corbett, TH; Griswold, DP; Laster, WR; Schabel, FM; Skipper, HE; Trader, MW | 1 |
| Frei, E | 2 |
| Grzelakowska-Sztabert, B | 1 |
| Mabel, JA; Wodinsky, I | 1 |
| Mathe, G | 1 |
| Ali-Osman, F; Maurer, HR | 1 |
| Dembo, M; Sirotnak, FM; Yang, CH | 3 |
| Moccio, DM; Sirotnak, FM; Yang, CH | 1 |
| Ciavarra, RP; Terres, G | 1 |
| Block, JB; Chlebowski, RT; Dietrich, MF; Isacoff, WH | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH; Uitendaal, MP | 1 |
| Dilliplane, P; Rahman, A; Sinks, LF; Woo, SY | 1 |
| Colman, P; Forsch, R; Moran, RG; Rosowsky, A; Uren, J; Wick, M | 1 |
| Besserer, JA; Boritzki, TJ; Fry, DW | 1 |
| Cheng, YC; Grill, SP; Wells, RJ | 1 |
| Drake, S; Nelson, JA | 1 |
| Nixon, PF; Wilson, L | 1 |
| Samuels, LL; Straw, JA | 1 |
| Mackinnon, WB; Nott, SE; Piper, AA; Tattersall, MH | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Henderson, GB; Montague-Wilkie, B | 1 |
| Henderson, GB | 3 |
| Perez, DJ; Tattersall, MH | 1 |
| Beckman, SB; Duffy, TH; Huennekens, FM | 1 |
| Bleyer, WA; Gangji, D; Glaubiger, DL; Poplack, DG; Ross, WE | 1 |
| Dembo, M; Moccio, DM; Sirotnak, FM | 1 |
| Bertino, JR; Cramer, SM; Horváth, C; Kalghatgi, KK; Schornagel, JH | 1 |
| Black, AM; Freisheim, JH; Kempton, RJ; Susten, SS | 1 |
| Fox, BW; McGown, AT; Poppitt, DG | 2 |
| Fox, BW; McGown, AT; Poppitt, DG; Swindell, R | 1 |
| Belousova, AK; Gerasimova, GK; Greshilov, MM; Vorontsov, IN | 2 |
| Henderson, GB; Russell, A; Whiteley, JM | 1 |
| Carpentier, Y; Desoize, B; Jardillier, JC; Kouamouo, J; Trentesaux, C | 1 |
| Berchtold, W; Bürki, H; Laissue, JA | 1 |
| Bertino, JR; Fernandes, DJ; Hynes, JB | 1 |
| Cheng, Y; Domin, BA; Grill, SP | 1 |
| Cheng, YC; Domin, BA; Li, SS; Pan, YC | 1 |
| Tattersall, MH | 2 |
| Bertino, JR; Kamen, BA; Whyte-Bauer, W | 1 |
| El Dareer, SM; Hill, DL; Strobel-Stevens, JD; Trader, MW | 1 |
| Cysyk, RL; Magin, RL; Weinstein, JN; Zaharko, DS | 1 |
| Coulter, D; Valeriote, F; Vietti, T | 1 |
| Fan, CC; Huennekens, FM; Vitols, KS | 1 |
| Chu, BC; Fan, CC; Howell, SB | 1 |
| Mulder, JH; Smink, T; van Putten, LM | 1 |
| Fujimoto, S; Ogawa, M; Sakurai, Y | 1 |
| Francis, PR; Slowiaczek, P; Tattersall, MH; Taylor, IW | 1 |
| Bertino, JR; Cashmore, AR; Dreyer, RN; Hsieh, P; Kamen, BA; Moroson, BA | 1 |
| Bruckner, H; Rubinoff, M; Waxman, S | 1 |
| Leyva, A; Nederbragt, H; Pinedo, HM; Uitendaal, MP; van der Grint, L | 1 |
| Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA | 1 |
| Chu, BC; Howell, SB | 1 |
| Freisheim, JH; McCormick, JI; Susten, SS | 1 |
| Cerna, I; Klubes, P; Meldon, MA | 1 |
| Bertino, JR | 1 |
| Bertino, JR; Kamen, BA | 1 |
| Harrap, KR; Renshaw, J | 1 |
| Mihich, E | 1 |
| Branski, D; Freeman, AI; Hatch, TF; Lebenthal, E | 1 |
| Mikulecky, DC; White, JC | 1 |
| Chello, PL; DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Goutas, LJ; Kelleher, LE; Moccio, DM; Montgomery, JA; Sirotnak, FM | 1 |
| Capizzi, RL; Keefe, DA; Rudnick, SA | 1 |
| Ciustea, G; Dobre, V; Muresan, Z; Niculescu-Duvaz, I; Stoicescu, D | 1 |
| Craescu, T; Niculescu-Duvaz, I | 1 |
| Chello, PL; Combepine, G; Gaumont, Y; Kisliuk, RL; Sirotnak, FM; Wong, E | 1 |
| Bardos, TJ; Gangjee, A; Kalman, TI | 1 |
| Henderson, GB; Huennekens, FM; Suresh, MR; Vitols, KS | 2 |
| Bernal, SD; Chen, LB; Shapiro, HM | 1 |
| Beardsley, P; Lazarus, H; Rosowsky, A; Shapiro, H; Wright, JE | 1 |
| Pogolotti, AL; Santi, DV | 1 |
| Armstrong, RD; Cadman, E; Snyder, P; Vera, R | 1 |
| Browman, GP; Csullog, GW | 1 |
| Blechman, WJ; Kim, K; Pardee, AB; Riddle, VG | 1 |
| Dulmadge, EA; Wilkoff, LJ | 1 |
| Chello, PL; Moccio, DM; Montgomery, JA; Parham, JC; Piper, JR; Sirotnak, FM | 1 |
| Goldman, ID; White, JC | 1 |
| Chang, BK; Huang, AT; Joines, WT | 2 |
| Hancock, CH; Moccio, DM; Sirotnak, FM; Young, CW | 1 |
| Goutas, LJ; Kelleher, LE; Moccio, DM; Sirotnak, FM | 1 |
| Henderson, GB; Huennekens, FM; Zevely, EM | 3 |
| Moran, RE; Straus, MJ | 1 |
| Calvert, AH; Dady, PJ; Grzelakowska-Sztabert, B; Harrap, KR; Jones, TR; Paine, RM; Taylor, GA | 1 |
| Grzelakowska-Sztabert, B; Henderson, GB; Huennekens, FM; Zevely, EM | 1 |
| Chello, PL; Dorick, DM; Sirotnak, FM | 2 |
| Abelson, HT; Browman, GP; Gorka, C; Lazarus, H; Mehta, C | 1 |
| Klubes, P; Miller, HG; Trevithick, J | 1 |
| Peck, C; Roberts, D | 1 |
| Abelson, HT; Beardsley, GP | 1 |
| Moccio, DM; Sirotnak, FM; Young, CW | 1 |
| Henderson, GB; Stein, CA | 1 |
| Brigle, KE; Goldman, ID; Sierra, EE; Spinella, MJ | 4 |
| Boyle, FT; Brown, M; Brunton, L; Jackman, AL; Kimbell, R | 1 |
| Góra-Tybor, J; Grieb, P; Robak, T; Warzocha, K | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Boyle, FT; Brown, M; Brunton, L; Harrap, KR; Jackman, AL; Kimbell, R; Wardleworth, JM | 1 |
| Schlemmer, SR; Sirotnak, FM | 3 |
| Asano, Y; Cheung, HT; Costello, M; Dong, Z; Escoffier, L; Smal, MA; Tattersall, MH | 1 |
| Henderson, GB; Saxena, M | 1 |
| Cheung, HT; Dong, Z; Escoffier, L; Smal, MA; Tattersall, MH | 1 |
| Bunni, MA; Otter, GM; Priest, DG; Sirotnak, FM | 1 |
| Gimmel, S; Maurer, HR | 1 |
| Góra-Tybor, J; Robak, T | 1 |
| Henderson, GB; Hughes, TR; Saxena, M | 1 |
| Chatelut, E; Kim, S; Suh, P | 1 |
| DeMiglio, MR; Feo, F; Muroni, MR; Nufris, A; Pascale, RM; Simile, MM | 1 |
| Awazu, S; Horie, T; Nagai, Y | 1 |
| Bertino, JR; Dicker, AP; Otter, GM; Schmid, FA; Schweitzer, BI; Sirotnak, FM; Volkenandt, M; Waltham, MC | 1 |
| Fetzer, OS; Freisheim, JH; Hynes, JB; Shane, B | 1 |
| Johnson, CA; Maddry, JA; McGuire, JJ; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Abraham, A; Galivan, J; Kisliuk, RL; McGuire, JJ; Nair, MG; Vishnuvajjala, BR | 1 |
| Freisheim, JH; Jansen, G; McAlinden, TP; Ratnam, M; Schornagel, JH; Williams, FE | 1 |
| Awazu, S; Horie, T; Nagai, Y; Yamamoto, J | 1 |
| Henderson, GB; Hughes, TR | 1 |
| Tsukagoshi, S | 1 |
| Banks, S; Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Heath, LS; Humphreys, J; Knick, V; Pendergast, W; Singer, S | 1 |
| Bhushan, A; Brinton, BT; Hacker, MP; Tritton, TR; Wroblewski, DH; Xuan, Y | 1 |
| Bhushan, A; Hacker, MP; Tritton, TR; Wroblewski, D; Xuan, Y | 1 |
| Kasamatsu, T; Kawazoe, Y; Kohda, K | 1 |
| Brigle, KE; Freemantle, SJ; Goldman, ID; Sierra, EE; Spinella, MJ | 1 |
| Pakulska, W | 1 |
| Higashigawa, M; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M | 1 |
| Fan, J; Jansen, G; Kohler, WJ; Ratnam, M; Ross, JF; Schornagel, J; Wang, X | 1 |
| Fan, J; Huennekens, FM | 1 |
| Brigle, KE; Goldman, ID; Seither, R; Sharina, IG; Wang, PJ; Zhao, R | 1 |
| Bekesi, JG; Holland, JF; Jiang, J; Roboz, J | 1 |
| Chiao, JH; Roy, K; Sirotnak, FM; Tolner, B | 1 |
| Assaraf, YG; Goldman, ID; Zhao, R | 1 |
| Brigle, K; Moran, RG; Taylor, SM; Tse, A | 1 |
| Aherne, GW; Boyle, FT; Brunton, L; Jackman, AL; Jansen, G; Kimbell, R; Smith, MN; Stephens, TC; Wardleworth, JM | 1 |
| Goldman, ID; Sierra, EE | 1 |
| Ishii, Y; Matsukubo, S; Nakamura, K; Nakano, S; Nyu, S; Uemura, N | 1 |
| Goldman, ID; Sharina, IG; Zhao, R | 1 |
| Bhushan, A; Hacker, MP; Tritton, TR | 1 |
| Gao, F; Goldman, ID; Zhao, R | 2 |
| Gao, F; Goldman, ID; Wang, PJ; Zhao, R | 1 |
| Assaraf, YG; Drori, S; Goldman, ID; Jansen, G; Shemer, G; Sprecher, H | 1 |
| Gao, F; Goldman, ID; Moran, RG; Titus, S; Zhao, R | 1 |
| Chiao, JH; Kühnel, JM; Sirotnak, FM | 1 |
| Babani, S; Gao, F; Goldman, ID; Zhao, R | 1 |
| Babani, S; Gao, F; Goldman, ID; Liu, L; Zhao, R | 1 |
| Diaz, GA; Gao, F; Gelb, BD; Goldman, ID; Wang, Y; Zhao, R | 1 |
| Huennekens, FM; Neef, VG | 2 |
| Bertino, JR; Greenfield, NJ; Gupta, SV; Makulu, DR; Moroson, BA; Poe, M; Williams, MN | 1 |
| Burchenal, JH; Chisholm, J; Kalaher, K; O'Toole, T | 1 |
| Henderson, GB; Huennekens, FM; Suresh, MR | 1 |
| Buesa, JM; Leyva, A; Pinedo, HM | 1 |
| Atchison, ML; Kimelberg, HK | 1 |
| Lee, M; Martin, DW; Santi, DV; Ullman, B | 1 |
| Andreeva, NA; Ershova, IuA; Nemeriuk, MP; Riabokon', NA; Sokolova, AS | 1 |
| Atkins, LM; Glae, GR; Meischen, SJ; Smith, AB; Walker, EM | 1 |
| Gordon, M; Henderson, GB; Huennekens, FM; Schrecker, AW; Smith, C; Vitols, KS; Zevely, EM | 1 |
| Buettner, GR; Burns, CP; Dudley, DT; Luttenegger, DG; Spector, AA | 1 |
| Cadman, E; Eiferman, F | 1 |
| Mulder, JH; van Putten, LM | 1 |
| Harrap, KR; Straw, JA; Talbot, DC; Taylor, GA | 1 |
| Donsbach, RC; Dorick, DM; Moccio, DM; Sirotnak, FM | 3 |
| Browman, GP; Harrap, KR; Taylor, GA | 1 |
| Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Grindey, GB; Pavelic, ZP; Semon, JH | 1 |
| Goldie, JH; Hill, BT | 1 |
| Henderson, GB; Russell, A; Singh, P; Whiteley, JM; Zevely, EM | 1 |
| Carpentier, Y; Desoize, B; Jardillier, JC; Rollet, C | 1 |
| Cadman, E; Davis, L; Heimer, R | 1 |
| Ensminger, WD; Rosowsky, A | 1 |
| Hilliard, S; Peck, C; Roberts, D; Wingo, W | 1 |
| Grindey, GB; Kinahan, JJ; Otten, M | 1 |
| Chello, PL; Combepine, G; Gaumont, Y; Kisliuk, RL; Moccio, DM; Montgomery, JA; Sirotnak, FM | 1 |
| Abelson, HT; Beardsley, GP; McCaffrey, RP; Rosowsky, A | 1 |
| Branski, D; Fisher, JE; Freeman, AI; Hatch, TF; Krasner, J; Lebenthal, E | 1 |
| Freisheim, JH; McCormick, JI; Rader, JI; Susten, SS | 1 |
| Hart, LI; Jackson, RC; Niethammer, D | 1 |
| Goldie, JH; Harrison, SI | 1 |
| Bender, RA; Makula, DM | 1 |
| Carpentier, Y; Desoize, B; Jardillier, JC | 1 |
| Hilliard, SL; Roberts, D | 1 |
| Prokhorova, EV | 1 |
| Bender, RA; Chabner, BA; Cohen, M; Donehower, R; Myers, CE | 1 |
| Grindey, GB; Semon, JH | 1 |
| DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Bender, RA; Nichols, AP; Norton, L; Simon, RM | 1 |
| Dobre, V; Ionescu, D; Niculescu-Duvăz, I; Suster, DC; Tărnăuceanu, E | 1 |
| Botez, G; Dobre, V; Niculescu-Duvăz, I; Suster, DC; Tărnăuceanu, E | 1 |
| Adamson, RH; Chirigos, MA; Przybylski, M; Ringsdorf, H; Schultz, RM; Zaharko, DS | 1 |
| Jain, RK; Sirotnak, FM; Weissbrod, JM | 1 |
| Goldin, A | 3 |
| Bonmassar, E; Goldin, A; Nicolin, A | 1 |
| Chello, PL; Peterson, RH; Sirotnak, FM; Yang, CH | 1 |
| Harrap, KR | 1 |
| Gang, M; Garibjanian, BT; Goldin, A; Johnson, RK; Kline, I; Vadlamudi, S; Venditti, JM | 1 |
| Chlopkiewicz, B; Koziorowska, J | 1 |
| Arons, E; Costa, MD; Fischer, C; Iqbal, MP; Rothenberg, SP | 1 |
| Elliott, RD; Frye, JL; Nontgomery, JA; Temple, C | 1 |
| Cramer, PL; Gapski, GR; Henderson, GB; Huennekens, FM; Neef, V; Rader, JI; Whiteley, JM | 1 |
| Brown, BL; Chaykovsky, M; Modest, EJ | 1 |
| Whitehead, VM | 1 |
| Fölsch, E; Makulu, DR | 1 |
| Hummel, H; Mattern, J; Volm, M | 1 |
| Chello, PL; Donsbach, RC; Dorick, DM; Sirotnak, FM | 1 |
| Dombernowsky, P; Nissen, NI | 1 |
| Frankfurt, OS; Goncharova, SA | 2 |
| Dembo, M; Sirotnak, FM | 1 |
| Goldies, JH; Hill, BT; Price, LA | 1 |
| Helfman, D; Zucker, RM | 1 |
| Hutchison, DJ; Otter, GM; Schmid, FA; Stock, CC | 1 |
| Burchenal, JH; Currie, VE; Dowling, MD; Fox, JJ; Krakoff, IH | 1 |
| Reif, AE; Robinson, CM; Smith, PJ | 1 |
| Brown, B; Frei, E; Tattersall, MH | 1 |
| Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH | 1 |
| Brown, BL; Frei, E; Tattersall, MH | 1 |
| Ashe, H; Chou, SC; Clark, BR; Halpern, BC; Halpern, RM; Hardy, DN; Jenkinson, PY; Smith, RA | 1 |
| Burchenal, JH | 1 |
| Cook, ES; Fardon, JC; Nutini, LG; Poydock, ME; Proudfoot, MB | 1 |
| Bruckner, HW; Schreiber, C; Waxman, S | 1 |
| Adamson, RH; Chabner, BA; Derr, CJ; Jacobs, SA; Johns, DC | 1 |
| Edelstein, M; Valeriote, F; Vietti, T | 1 |
| Grindey, GB; Moran, RG | 1 |
| Arakawa, M; Shimizu, F | 1 |
| Donsback, RC; Sirotnak, FM | 1 |
| Chodera, A; Hladoń, B | 1 |
| Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O | 1 |
| Fan, J; Huennekens, FM; Vitols, KS | 2 |
| Kwok, JB; Tattersall, MH | 1 |
| Robak, T; Warzocha, K | 1 |
| Jackman, AL; Jansen, G; Kathmann, I; Rijksen, G; Schornagel, JH; van Emmerik, N; Westerhof, GR | 1 |
| Frank, N; Osswald, H | 1 |
| Christopherson, RI; Lyons, SD | 1 |
| da Costa, M; Iqbal, MP; Rothenberg, SP | 1 |
| Cao, S; Wu, S; Xue, Y; Zhen, Y | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 2 |
| Gałazka, G; Graczyk, J; Korycka, A; Kłysik, J; Pakulska, W; Robak, T; Warzocha, K | 1 |
| Furuta, T; Yokokura, T | 1 |
| Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA | 1 |
| Scheulen, ME | 1 |
| Belt, JA; Crawford, CR; Ng, CY | 1 |
| O'Leary, DF; Sirotnak, FM | 1 |
| Fujimoto, T; Katano, N; Niwa, M; Tsurusawa, M | 2 |
| Fan, J; Huennekens, FM; Pope, LE; Vitols, KS | 1 |
| Otter, GM; Rumberger, BG; Schmid, FA; Sirotnak, FM | 1 |
| Esswein, A; Huennekens, FM; Kuefner, U; Lohrmann, U; Montejano, Y; Vitols, KS | 1 |
| Berenbaum, MC | 1 |
| Henderson, GB; Tsuji, JM | 3 |
| Henderson, GB; Strauss, BP | 2 |
| Iqbal, MP; Larosa, C; Rothenberg, SP | 1 |
| Barlowe, CK; Goldman, ID; Matherly, LH | 1 |
| Goutas, LJ; Piper, JR; Priest, DG; Samuels, LL; Sirotnak, FM | 1 |
| Ishioka, C; Kakuta, H; Kanamaru, R; Sato, T; Wakui, A | 1 |
| Goldman, ID; Rape, TJ; Seither, RL | 1 |
| Balińska, M | 1 |
| Cao, SS | 1 |
| Baldwin, SW; Moran, RG; Shih, C; Taylor, EC | 1 |
| Boschelli, D; Ferguson, K; Freishiem, J; Galivan, J; Hoffman, P; Hynes, J; Kerwar, SS; Oronsky, A; Webber, S; Whiteley, J | 1 |
| Petrov, SA | 1 |
| Braakhuis, BJ; Jansen, G; Kathmann, I; Rademaker, BC; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
| Antonjuk, DJ; Boadle, DK; Cheung, HT; Friedlander, ML; Gregory, PM; Tattersall, MH | 1 |
| Freisheim, JH; Price, EM; Ratnam, M | 1 |
| Bunni, M; Priest, DG; Sirotnak, FM | 1 |
| FitzGerald, GB; Wick, MM | 2 |
| Hrubisko, M; Kuliffay, P; Kysela, B | 1 |
| Goldman, ID; Matherly, LH; Pincus, R; Schuetz, JD; Swerdlow, PS; Westin, EH | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Goldman, ID; Matherly, LH; Schuetz, JD; Westin, EH | 1 |
| Florence, AT; Halbert, GW; Stuart, JF | 2 |
| Beardsley, GP; Moran, RG; Moroson, BA; Taylor, EC | 1 |
| Griswold, DP; Hook, KE; Leopold, WR; Nelson, JM; Roberts, BJ | 1 |
| FitzGerald, GB; Ratliff, J; Wick, MM | 1 |
| Goldman, ID; Gorse, KM; Schuetz, JD; Westin, EH | 1 |
| Delcamp, TJ; Freisheim, JH; Kumar, AA; Price, EM; Smith, PL; Susten, SS | 1 |
| Cashmore, AR; Dreyer, RN; Kashani-Sabet, M; Moroson, BA; Pallai, M; Saketos, M; Scanlon, KJ | 1 |
| Kalman, TI; Yalowich, JC | 1 |
| Boschelli, DH; Kerwar, SS; Oronsky, AL; Webber, S; Whiteley, JM | 1 |
| DeGraw, JI; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Freisheim, JH; Price, EM; Ratnam, M; Rodeman, KM | 1 |
| Delcamp, TJ; Freisheim, JH; Price, EM; Ratnam, M; Smith, PL | 1 |
| Holczinger, L; Hullán, L; Szikla, K; Tusnády, G | 1 |
| Bunni, M; Doig, MT; Donato, H; Kesavan, V; Priest, DG | 1 |
| Forsch, RA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Fairchild, CR; Maybaum, J; Straw, JA | 1 |
| Bader, H; Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Solan, VC | 1 |
| Kamiya, H; Nobori, T | 1 |
| Barrueco, JR; Poser, RE; Sirotnak, FM | 1 |
| Coates, A | 1 |
| Dei, T; Ishioka, C; Kakuta, H; Kanamaru, R; Konishi, Y; Sato, T; Wakui, A | 1 |
| Campbell, ED; Carter, WH; Goldman, ID; Wampler, GL | 1 |
| Barrueco, JR; Gaumont, Y; Goutas, LJ; Jacobsen, DM; Kisliuk, RL; Mines, LS; Sirotnak, FM | 1 |
| Freisheim, JH; Klein, TE; Price, EM; Smith, PL | 1 |
| Freisheim, JH; Price, EM | 1 |
| Kamiya, H; Kawasaki, H; Nobori, T; Ochiai, H; Ohkubo, T; Sakurai, M; Shimizu, N | 1 |
| Hirota, H; Kamiya, H; Kawasaki, H; Komada, M; Nobori, T; Ohkubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Colman, PD; Forsch, RA; Freisheim, JH; Moran, RC; Radike-Smith, M; Rosowsky, A; Wick, MM | 1 |
| Gale, GR; Hynes, JB; Smith, AB | 1 |
| Cashmore, AR; Kashani-Sabet, M; Moroson, BA; Pallai, M; Saketos, M; Scanlon, KJ | 1 |
| Duffy, TH; Huennekens, FM; Sato, JK; Vitols, KS | 1 |
| Arnold, LJ | 1 |
| Goutas, LJ; Mines, LS; Sirotnak, FM | 1 |
| Cadman, E; Danhauser, LL; Heimer, R | 1 |
| Sirotnak, FM | 1 |
| Cheng, YC; Dutschman, GE; Fisher, MH; Nair, MG; Nanavathi, NT; Starnes, MC | 1 |
| Hoshino, A; Ito, Y; Machida, S | 1 |
| Gupta, SP; Handa, A; Prabhakar, YS | 1 |
| Delcamp, TJ; Freisheim, JH; Hansch, C; Khwaja, TA; Selassie, CD; Strong, CD | 1 |
| Doig, MT; Kesavan, V; Priest, DG; Scanlon, KJ; Sur, P | 1 |
| Henderson, GB; Kumar, HP; Tsuji, JM | 1 |
| Forsch, RA; Freisheim, JH; Galivan, J; Rosowsky, A; Susten, SS | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| Kamiya, H; Kawasaki, H; Nobori, T; Sakurai, M | 1 |
| Freisheim, JH; Hynes, JB; Kumar, A; Susten, SS | 1 |
| Hashimoto, K; Kinsky, SC; Knight, MS; Loader, JE | 1 |
| Hirota, H; Izawa, T; Kamiya, H; Kawasaki, H; Komada, M; Noboru, T; Okubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Hirota, H; Kamiya, H; Kawasaki, H; Komada, M; Nobori, T; Okubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Beckman, SB; Duffy, TH; Huennekens, FM; Nagae, H; Sato, JK; Vitols, KS | 1 |
| Herrmann, R; Osswald, H; Youssef, M | 1 |
| Gang, M; Kline, I; Sirica, AE; Venditti, JM; Woodman, RJ | 1 |
| Frisby, SA; Oliverio, VT; Zager, RF | 1 |
| Rubens, RD | 1 |
| Kline, I | 1 |
| Huennekens, FM; Jackson, RC | 1 |
| DiGirolamo, PM; Fujii, K; Henderson, GB; Huennekens, FM; Jacobsen, DW; Neef, VG; Rader, JI | 1 |
| Rosowsky, A | 1 |
| Mellett, LB | 1 |
| Chaykovsky, M; Chen, KK; Gaumont, Y; Kisliuk, RL; Modest, EJ; Papathanasopoulos, N; Rosowsky, A | 1 |
| Chen, KK; Rosowsky, A | 1 |
| Grindey, GB; Nichol, CA | 1 |
| Harrap, KR; Jackson, RC | 1 |
| Bergsagel, DE | 1 |
| Gauldie, J; Hiebert, M; Hillcoat, BL; Marshall, L | 1 |
| Bertino, JR; Perkins, JP | 1 |
| Bertino, JR; Hillcoat, BL; Perkins, JP | 2 |
| Bertino, JR; Cashmore, AR; Hillcoat, BL | 1 |
| Hutchison, DJ | 3 |
| Gauldie, J; Hillcoat, BL | 1 |
| Bertino, JR; McCullough, JL | 1 |
| Donsbach, RC; Sirotnak, FM | 4 |
| Bazhanov, VS; Shorin, VA | 1 |
| Avery, TL; Roberts, D | 1 |
| Brugerie, E; Huong, TH; Lheritier, J; Pouillart, R | 1 |
| Huennekens, FM; Niethammer, D; Rader, JI | 1 |
| Mead, JA; Mishra, LC | 1 |
| Bleyer, WA; Yancey, ST | 1 |
| Bertino, JR; Cashmore, AR; Coward, JK; Parameswaran, KN | 1 |
| Connors, TA; Harrap, KR; Jackson, RC; Tattersall, MH | 1 |
| Harrap, KR; Jackson, RC; Jackson, ST; Tattersall, MH | 1 |
| Adamson, RH; Hahn, MA | 1 |
| Drais, JH; Huennekens, FM; Jackson, RC; Mell, GP; Whiteley, JM | 1 |
| Artis, EW; Gang, M; Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 2 |
| Averbukh, LA; Bazhanov, VS; Grinshteĭn, AM; Lepeshkina, GN; Shorin, VA | 1 |
| Hutchison, DJ; Schmid, FA; Stock, CC; Tarnowski, GS | 1 |
| Chabner, BA; Young, RC | 1 |
| Farquhar, D; Johns, DG; Loo, TL | 1 |
| Fyfe, MJ; Goldman, ID | 1 |
| Adamson, RH; Chabner, BA; Farquhar, D; Johns, DG; Wolpert, MK | 1 |
| Goldin, A; Miyakawa, A; Padarathsingh, M; Vadlamudi, S | 1 |
| Bertino, JR; Cashmore, AR; Sawicki, WL; Skeel, RT | 1 |
| Jacquez, JA; Ullman, NS | 1 |
| Ackerman, GA; Goodman, MT | 1 |
| Goodman, L; Lee, WW; Martinez, AP | 1 |
| Calman, NS; Eng, B; Slater, LM; Wallerstein, H | 1 |
| Hillcoat, BL; Kawai, M | 1 |
| Bick, R; Botez, G; Ciustea, G; Dobre, V; Feyns, VL; Niculescu-Duvăz, I; Suster, DC | 1 |
| Crawford, EJ; Friedkin, M; Livingston, D | 1 |
| Benckhuijsen, C | 1 |
| Vermel', EM | 1 |
| Baker, BR | 1 |
| Bertino, JR; Chabner, B; Levitt, M; McCullough, JL | 1 |
| Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS | 1 |
| Adamson, RH; Denham, C; Henderson, ES; Oliverio, VT | 1 |
| Crawford, EJ; Friedkin, M; Goldin, A; Kisliuk, RL; Kwok, G; Mead, JA; Plante, L | 1 |
| Elliott, RD; Montgomery, JA; Straight, SL; Temple, C | 1 |
| Harding, NG | 1 |
| Hofer, KG | 2 |
| Adamson, RH; Gallo, RC; Riddick, D; Waalkes, TP | 1 |
| Hutchison, DJ; Schmid, FA | 2 |
| Lamerton, LF | 1 |
| Bertino, JR; Cashmore, AR; Chello, PL; Jacobs, SA | 1 |
| Bertino, JR; Nahas, A; Nixon, PF | 1 |
| Goldin, A; Straus, MJ | 2 |
| Bobzien, WF; Goldman, ID | 1 |
| Farquhar, D; Loo, TL | 1 |
| Friedkin, M; Nahas, A | 1 |
| Goldin, A; Mantel, N; Straus, MJ | 2 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 1 |
| Calman, N; Eng, B; Slater, LM; Wallerstein, H | 2 |
| Russell, DH | 1 |
| Goldman, ID | 3 |
| Mead, JA; Mishra, LC; Parmar, AS | 2 |
| Goldin, A; Greenberg, NH; Mead, JA; Schrecker, AW | 2 |
| Hutchison, DJ; Kurita, S; Robinson, DL; Sargent, MG; Sirotnak, FM | 1 |
| Hirshaut, Y; Perry, S; Weiss, GH | 1 |
| Zubrod, CG | 1 |
| Bertino, JR; Capizzi, RL; Cashmore, AR; Johns, DG; Nahas, A | 1 |
| Bertino, JR; D'Urso-Scott, M; Jacobs, SA | 1 |
| Furness, ME; Harrap, KR; Hart, LI; Hill, BT | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Abboud, G; Bertino, JR; Fölsch, E; Gralla, E | 1 |
| Mead, JA | 1 |
| Amiel, JL; Cattan, A; Mathé, G; Pouillart, P; Schneider, M; Schwarzenberg, L | 1 |
| Goldman, ID; Lichtenstein, NS; Oliverio, VT | 2 |
| Hayat, M; Mathé, G; Schneider, M; Schwarzenberg, L | 1 |
| Goldin, A; Sandberg, JS | 1 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Amiel, JL; Cattan, A; Mathé, G; Schneider, M; Schwarzenberg, L | 1 |
| Kessel, D | 1 |
| Mathé, G; Schneider, M; Schwarzenberg, L | 1 |
| Harding, NG; Huennekens, FM; Martelli, MF | 1 |
| Collings, AJ; Elson, LA; Mitchlev, BC; Schneider, R | 1 |
| Brambilla, G; Caraceni, CE; Cavanna, M; Parodi, S | 1 |
| Himmelfarb, P; Roberts, D; Thayer, PS | 1 |
| Cheng, CC; Grabowski, BF; Weinstock, LT | 1 |
| Aoki, T; Arakawa, M; Nakao, H | 1 |
| Brockman, RW; Lloyd, HH; Mellett, LB; Montgomery, JA; Schabel, FM; Skipper, HE; Wilkoff, LJ | 1 |
| Goldman, ID; Lichtenstein, NS | 1 |
| Hillcoat, BL | 1 |
| Hutchison, DJ; Kurita, S; Sirotnak, FM | 1 |
| Gang, M; Goldin, A; Kline, I; Mantel, N; Venditti, JM | 1 |
| Roberts, D; Wodinsky, I | 1 |
| Baldini, L; Brambilla, G; Cavanna, M; Parodi, S | 1 |
| Hofer, KG; Hughes, WL; Prensky, W; Rosenoff, S | 1 |
| Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 2 |
| Thomas, LB | 1 |
| Hardy, WG; Johnson, RE; Zelen, M | 1 |
| Albrecht, AM; Biedler, JL; Hoshino, A; Hutchison, DJ | 1 |
| Chirigos, MA; Humphreys, SR | 1 |
| Bjerregaard, MR; Hutchison, DJ; Ittensohn, OL | 1 |
| Schabel, FM; Skipper, HE; Wilcox, WS | 1 |
| Goldin, A; Kline, I; Mead, JA; Tyrer, DD; Venditti, JM | 1 |
| Albrecht, AM; Hoshino, A; Hutchison, DJ | 1 |
31 review(s) available for methotrexate and Leukemia L 1210
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
DRUG SYNERGISM IN ANTINEOPLASTIC CHEMOTHERAPY.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Leukemia L1210; Methotrexate; Pharmacology; Research | 1964 |
[Liposomes--carriers of cytostatic preparations].
Topics: Adsorption; Animals; Antineoplastic Agents; Cytarabine; Dactinomycin; Doxorubicin; Leukemia L1210; Lipoproteins; Liposomes; Methotrexate; Mice; Tissue Distribution | 1984 |
Establishment of cross-resistance profiles for new agents.
Topics: Animals; Antineoplastic Agents; Cell Line; Doxorubicin; Drug Resistance; Humans; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Methotrexate; Phenotype; Vincristine | 1983 |
Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer.
Topics: Acute Disease; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Division; Child; Child, Preschool; Clinical Trials as Topic; Hodgkin Disease; Humans; Infant; Kinetics; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Mice; Models, Biological | 1984 |
[Molecular mechanisms of cellular resistance to antifolates].
Topics: Animals; Biological Availability; Biological Transport; Carcinoma 256, Walker; Cricetinae; Cricetulus; Drug Resistance; Enzyme Activation; Enzyme Induction; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; RNA, Messenger; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase | 1983 |
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin | 1980 |
Folate and anti-folate transport in mammalian cells.
Topics: Animals; Biological Transport; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Leukemia L5178; Liver Neoplasms, Experimental; Methotrexate; Neoplasms, Experimental | 1980 |
Intracellular nucleotide pools and their significance in antimetabolite therapy.
Topics: 3-Deazauridine; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Coformycin; Cricetinae; Cricetulus; Cytarabine; HeLa Cells; Humans; Leukemia L1210; Methotrexate; Nucleic Acids; Pyrimidine Nucleotides | 1980 |
Biochemical pharmacological determinants of drug action in cancer therapeutics.
Topics: Animals; Biotransformation; Cytarabine; Humans; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice; Rats | 1980 |
Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: a network model for methotrexate action as a comprehensive example.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Membrane; Computers; Humans; Kinetics; Leukemia L1210; Methotrexate; Models, Theoretical; Neoplasms; Thermodynamics | 1981 |
The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Clinical Trials, Phase II as Topic; Drug Resistance; Humans; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine | 1976 |
Anti-folate toxicity and its reversal.
Topics: Animals; Bone Marrow; Cell Line; DNA Replication; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Intestinal Mucosa; Intestines; Kinetics; Leukemia L1210; Methotrexate; Mice | 1976 |
Murine and human leukemias.
Topics: Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred AKR; Prednisone; Vincristine | 1975 |
Development of drug derivatives without cross-resistance to parent compounds.
Topics: Animals; Antineoplastic Agents; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Glutathione; Humans; Leukemia L1210; Methotrexate; Pyrimethamine; Tumor Cells, Cultured | 1990 |
Visualization of folate transport proteins by covalent labeling with fluorescein methotrexate.
Topics: Animals; Carrier Proteins; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface | 1990 |
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.
Topics: Animals; Biological Transport; Cell Division; Cell Transformation, Neoplastic; Extraembryonic Membranes; Female; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Neoplasms; Oncogenes; Pregnancy | 1985 |
Folic acid and vitamin B12: transport and conversion to coenzyme forms.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Membrane; Coenzymes; Folic Acid; Kinetics; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Models, Biological; Mutation; NADP; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Vitamin B 12 | 1974 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Leukemia, Lymphoid; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Nitrogen Mustard Compounds; Prednisone; Pregnancy; Time Factors; Trophoblastic Neoplasms; Vinblastine | 1971 |
Antifolate resistance and the genetic control of dihydrofolate reductase activity.
Topics: Animals; Chromosome Aberrations; DNA Replication; DNA, Bacterial; Drug Resistance; Drug Resistance, Microbial; Enterococcus faecalis; Leukemia L1210; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Nucleic Acid Hybridization; Phenotype; Protein Binding; Radiation Effects; Streptococcus pneumoniae; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1971 |
The emergence of drug resistance in tumours: a characteristic which may be exploited therapeutically.
Topics: Aminohydrolases; Animals; Cytarabine; Cytidine; DNA; Drug Resistance; Humans; Leukemia; Leukemia L1210; Methotrexate; Neoplasms | 1973 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine | 1969 |
Factors pertaining to complete drug-induced remission of tumor in animals and man.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nitroso Compounds; Urea | 1969 |
[Current views on drug therapy of tumors].
Topics: Animals; Antineoplastic Agents; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyclophosphamide; Dactinomycin; Humans; Hyperbaric Oxygenation; Leukemia L1210; Lymphoma; Methotrexate; Mitomycins; Neoplasms; Vincristine | 1970 |
Active-site directed irreversible inhibitors of dihydrofolate reductase.
Topics: Aminopterin; Animals; Binding Sites; Biological Transport, Active; Carcinoma 256, Walker; Folic Acid Antagonists; Intestines; Kidney; Leukemia L1210; Liver; Methotrexate; Mice; Pyrimethamine; Rats; Spleen; Structure-Activity Relationship; Time Factors; Triazines | 1971 |
New approaches to chemotherapy with folate antagonists: use of leucovorin "rescue" and enzymic folate depletion.
Topics: Adult; Animals; Carboxypeptidases; Carcinoma 256, Walker; Carcinoma, Squamous Cell; Deoxyuridine; Diet; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Mice; Rats; Tritium | 1971 |
Combination chemotherapy with folate antagonists.
Topics: Adult; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Child; Drug Combinations; Drug Interactions; Drug Synergism; Folic Acid Antagonists; Humans; Injections, Subcutaneous; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Mice; Mice, Inbred Strains; Nitrogen Mustard Compounds; Prednisone; Time Factors | 1971 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
New approaches to chemotherapy.
Topics: Administration, Oral; Aminopterin; Animals; Enterococcus faecalis; Folic Acid Antagonists; Injections, Intraperitoneal; Lethal Dose 50; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines | 1971 |
4 trial(s) available for methotrexate and Leukemia L 1210
| Article | Year |
|---|---|
Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer.
Topics: Acute Disease; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Division; Child; Child, Preschool; Clinical Trials as Topic; Hodgkin Disease; Humans; Infant; Kinetics; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Mice; Models, Biological | 1984 |
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Head and Neck Neoplasms; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Purines; Random Allocation; Thymidine | 1983 |
Sequential MTX and 5-FU: advance or myth?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Clinical Trials as Topic; Fluorouracil; Head and Neck Neoplasms; Humans; Leukemia L1210; Methotrexate; Mice | 1986 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
574 other study(ies) available for methotrexate and Leukemia L 1210
| Article | Year |
|---|---|
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Male; Methods; Methotrexate; Mice; Thymidylate Synthase | 1979 |
Synthesis of aza homologues of folic acid.
Topics: Animals; Antineoplastic Agents; Folic Acid; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Male; Mice; Pediococcus; Streptococcus; Thymidylate Synthase | 1979 |
Methotrexate analogues. 10. Direct coupling of methotrexate and diethyl L-glutamate in the presence of peptide bond-forming reagents.
Topics: Animals; Cells, Cultured; Glutamates; Humans; Indicators and Reagents; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Stereoisomerism | 1978 |
Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.
Topics: Amides; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, Thin Layer; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Methotrexate; Mice; Rats | 1977 |
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues.
Topics: Animals; Antineoplastic Agents; Cell Line; Folic Acid Antagonists; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Male; Methods; Methotrexate; Mice; Thymidylate Synthase | 1977 |
Analogues of methotrexate.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Survival; Columbidae; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia L1210; Liver; Methotrexate; Mice; Structure-Activity Relationship | 1979 |
Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Mice; Quinazolines; Rats; Streptococcus; Structure-Activity Relationship | 1977 |
Sycnthesis of quinazoline analogues of folic acid modified at postion 10.
Topics: Animals; Antineoplastic Agents; Folic Acid; Leukemia L1210; Mice; Quinazolines | 1977 |
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Glutamates; Guanine; Humans; Leukemia L1210; Leukemia, Lymphoid; Mice; Pemetrexed; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
Topics: Aminopterin; Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia L1210; Tumor Cells, Cultured | 1992 |
Pyrazole-related nucleosides. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; B-Lymphocytes; Cell Division; Cyclization; Enterovirus; Glycosylation; HIV-1; Humans; Leukemia L1210; Mice; Molecular Structure; Nucleosides; Organosilicon Compounds; Pyrazoles; Silicon; Structure-Activity Relationship; T-Lymphocytes; Tumor Cells, Cultured; Vero Cells | 1992 |
Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
Topics: Aminopterin; Animals; Cell Division; Folic Acid Antagonists; Leukemia L1210; Mammary Neoplasms, Experimental; Methotrexate; Mice; Tumor Cells, Cultured | 1992 |
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Topics: Aminopterin; Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.
Topics: Aminopterin; Animals; Cyanides; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Molecular Structure; Optical Rotation; Spectrophotometry, Infrared; Structure-Activity Relationship | 1991 |
Folic acid analogues lacking the 2-carbon are substrates for folylpolyglutamate synthetase and inhibit cell growth.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Leukemia L1210; Mice; Molecular Structure; Peptide Synthases; Structure-Activity Relationship; Substrate Specificity | 1991 |
Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Line; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1991 |
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
Topics: Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Methotrexate; Molecular Structure; Tumor Cells, Cultured | 1990 |
Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.
Topics: Acyltransferases; Animals; Antimetabolites, Antineoplastic; Cell Division; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Tetrahydrofolates; Tumor Cells, Cultured | 1990 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Topics: Aminopterin; Animals; Bacteria; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Polyglutamic Acid; Structure-Activity Relationship | 1986 |
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.
Topics: Animals; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Peptide Synthases; Polyglutamic Acid; Structure-Activity Relationship; Thymidylate Synthase | 1986 |
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Mice; Molecular Structure; Phosphoribosylglycinamide Formyltransferase; Purines; Stereoisomerism; Streptococcus; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1989 |
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Topics: Aminobutyrates; Aminopterin; Animals; beta-Alanine; Cell Division; Folic Acid Antagonists; Glutamates; Glutamic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Molecular Weight; Ornithine; Peptide Synthases | 1986 |
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Topics: Amino Acids, Dicarboxylic; Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Glutamates; Glutamic Acid; Humans; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Quinazolines; Streptococcus; Structure-Activity Relationship; Thymidylate Synthase | 1986 |
Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Streptococcus; Thymidylate Synthase | 1986 |
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.
Topics: Animals; Folic Acid; Indicators and Reagents; Lacticaseibacillus casei; Leukemia L1210; Mice; Microbial Sensitivity Tests; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1986 |
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.
Topics: Acetates; Animals; Candida albicans; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Isoxazoles; Leukemia L1210; Lysine; Methotrexate; Mice; NADP; Ornithine; Protein Conformation; Spectrophotometry | 1987 |
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.
Topics: Acyltransferases; Animals; Anti-Bacterial Agents; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Indicators and Reagents; Lacticaseibacillus casei; Leukemia L1210; Mice; Microbial Sensitivity Tests; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Streptococcus; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1988 |
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Cell Cycle; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Phosphoribosylglycinamide Formyltransferase; Tetrahydrofolates | 1988 |
Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Isomerism; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Structure-Activity Relationship | 1988 |
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ornithine; Peptide Synthases; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Topics: Amides; Aminopterin; Animals; Cell Line; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice | 1986 |
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
Topics: Aminopterin; Animals; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Stereoisomerism; Structure-Activity Relationship | 1986 |
Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Drug Resistance; Esterification; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia; Leukemia L1210; Methotrexate; Mice; T-Lymphocytes | 1985 |
Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogues of folic acid.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Leukemia L1210; Liver; Methotrexate; Mice | 1985 |
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Topics: Amide Synthases; Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia L1210; Ligases; Male; Methotrexate; Tetrahydrofolates; Thymidylate Synthase | 1985 |
Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids.
Topics: Animals; Carboxylic Acids; Cell Division; Cells, Cultured; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1985 |
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Glutamates; Glutamic Acid; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice | 1983 |
Novel fluorinated antifolates. Enzyme inhibition and cytotoxicity studies on 2'- and 3'-fluoroaminopterin.
Topics: Aminopterin; Animals; Cell Line; Cell Survival; Escherichia coli; Folic Acid Antagonists; HeLa Cells; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice | 1983 |
Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.
Topics: Amino Acids, Sulfur; Aminopterin; Animals; Antineoplastic Agents; Carboxypeptidases; Cysteic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Homocysteine; Indicators and Reagents; Leukemia L1210; Liver; Methotrexate; Mice; Structure-Activity Relationship | 1984 |
Methotrexate analogues. 18. Enhancement of the antitumor effect of methotrexate and 3',5'-dichloromethotrexate by the use of lipid-soluble diesters.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Esters; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Mice; Spectrophotometry, Infrared; Structure-Activity Relationship | 1983 |
Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
Topics: Aminopterin; Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Thymidylate Synthase | 1984 |
Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Liver Neoplasms, Experimental; Methotrexate; Mice; Peptides; Polylysine; Rats; Tetrahydrofolate Dehydrogenase | 1984 |
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.
Topics: Animals; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus; Thymidylate Synthase | 1980 |
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chemical Phenomena; Chemistry; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus | 1981 |
Methotrexate analogues. 14. Synthesis of new gamma-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice | 1981 |
Methotrexate analogues. 16. Importance of the side-chain amide carbonyl group as a structural determinant of biological activity.
Topics: Animals; Binding, Competitive; Cell Survival; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1982 |
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.
Topics: Amides; Animals; Cells, Cultured; Esters; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Peptides | 1982 |
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma 180 | 1982 |
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Chemical Phenomena; Chemistry; Kinetics; Leukemia L1210; Mice | 1982 |
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Nucleosides; Pyridazines; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Topics: Aminopterin; Animals; Benzoates; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Folic Acid Antagonists; Humans; Leukemia L1210; Liver; Mammary Neoplasms, Experimental; Methotrexate; Mice; Models, Molecular; Molecular Structure; Naphthalenes; Pneumocystis; Rats; Structure-Activity Relationship; Toxoplasma; Tumor Cells, Cultured | 1993 |
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship | 1993 |
Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.
Topics: Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Histidine; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; Peptide Synthases | 1996 |
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Leukemia L1210; Methotrexate; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tritium; Tumor Cells, Cultured | 2000 |
Combined antitumoral effects of pretubulysin and methotrexate.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Female; Humans; Leukemia L1210; Methotrexate; Mice; Mice, Nude; Neoplasms; Oligopeptides; Uterine Cervical Neoplasms | 2019 |
Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Dynamic Light Scattering; Female; Leukemia L1210; Methotrexate; Mice; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Oligopeptides | 2019 |
Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.
Topics: Animals; Drug Resistance, Neoplasm; HSC70 Heat-Shock Proteins; Leukemia L1210; Methotrexate; Mice; Microscopy, Confocal; Phosphorylation; Reduced Folate Carrier Protein; Tyrosine | 2015 |
[Platelets Decrease the Sensitivity of Leukemia Cell L1210 to Multiple Drugs via Activiting The AKT and ERK Signalling Pathway].
Topics: Animals; Blood Platelets; Cell Proliferation; Doxorubicin; Leukemia L1210; MAP Kinase Signaling System; Methotrexate; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Vincristine | 2016 |
Effects of extracellular purines on cytotoxicity of methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Survival; Culture Media, Conditioned; Deoxyribonucleotides; Dipyridamole; Drug Synergism; Hypoxanthine; Leukemia L1210; Methotrexate; Mice; Purines; Tumor Stem Cell Assay | 2010 |
Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.
Topics: Animals; Antimetabolites, Antineoplastic; Leucovorin; Leukemia L1210; Methotrexate; Mice; Vitamin B Complex | 1966 |
Identification and characterization of a 66-68-kDa protein as a methotrexate-binding protein in murine leukemia L1210 cells.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Chromatography, Affinity; Cisplatin; Databases, Factual; Drug Resistance, Neoplasm; Escherichia coli; Escherichia coli Proteins; HSP70 Heat-Shock Proteins; Leukemia L1210; Methotrexate; Mice; Molecular Sequence Data; Peptides; Phosphorylation; Protein Structure, Tertiary; Recombinant Proteins | 2013 |
Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
Topics: Amino Acid Substitution; Animals; Binding Sites; Biological Transport; Carrier Proteins; DNA Primers; Folic Acid; Kinetics; Leukemia L1210; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Recombinant Proteins; Reduced Folate Carrier Protein; Transfection; Tumor Cells, Cultured | 2003 |
Effectiveness of 2-chloro-4',4"-di-2-imidazolin-2-ylterephthal-anilide and methotrexate, in combination, against advanced leukemia L1210.
Topics: Anilides; Animals; Antineoplastic Agents; Leukemia L1210; Methotrexate | 1963 |
The antileukemic effectiveness of methylglyoxal bis(guanylhydrazone) in mice. Studies of cross-resistance and combination chemotherapy.
Topics: Animals; Antineoplastic Agents; Drug Therapy, Combination; Hydrazines; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mitoguazone; Pyruvaldehyde | 1963 |
STUDIES ON IMMUNITY TO LEUKEMIA L1210 IN MICE.
Topics: Animals; Immunity; Leukemia L1210; Methotrexate; Mice; Neoplasms; Research; Skin Transplantation; Spleen; Tissue Extracts | 1963 |
ASSOCIATION OF INCREASED DIHYDROFOLATE REDUCTASE LEVELS AND CHROMOSOME ALTERATION IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210.
Topics: Animals; Azaserine; Chromosomes; Fluorouracil; Folic Acid; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Oxidoreductases; Research; Tetrahydrofolate Dehydrogenase | 1963 |
SELECTION OF CHROMOSOMAL VARIANT IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210 WITH INCREASED LEVELS OF DIHYDROFOLATE REDUCTASE.
Topics: Animals; Chromosomes; Fluorouracil; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Oxidoreductases; Research; Tetrahydrofolate Dehydrogenase | 1963 |
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.
Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
THE EFFECT OF A PHTHALANILIDE DERIVATIVE ON LIPIDE METABOLISM IN L1210 LEUKEMIA CELLS.
Topics: Anilides; Animals; Antineoplastic Agents; Carbon Isotopes; Cholesterol; Cyclophosphamide; Fatty Acids; Fluorouracil; Leukemia L1210; Lipid Metabolism; Mercaptopurine; Methotrexate; Mice; Nitroso Compounds; Pharmacology; Phthalic Acids; Research | 1964 |
THERAPEUTIC AND IMMUNOLOGICAL RESPONSE OF MICE WITH MENINGEAL LEUKEMIA (L1210) TO CHALLENGE WITH AN ANTIFOLIC-RESISTANT VARIANT.
Topics: Animals; Cyclophosphamide; Folic Acid Antagonists; Leukemia; Leukemia L1210; Leukemia, Experimental; Meninges; Methotrexate; Mice; Neoplasms; Pathology; Radiation Effects; Research | 1964 |
THE CORRELATION BETWEEN TRANSPLANTED MOUSE AND HUMAN ACUTE LEUKEMIAS.
Topics: Aldehydes; Anilides; Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Vincristine | 1964 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
FURTHER OBSERVATIONS OF THE BINDING AND INHIBITION OF DIHYDROFOLIC REDUCTASE BY FOLIC ACID ANTAGONISTS.
Topics: Aminopterin; Animals; Chromatography; Dialysis; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Hot Temperature; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Potassium; Poultry; Renal Dialysis; Research; Tritium; Urea | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Research; Thioguanine; Thiotepa; Toxicology | 1964 |
THE EFFECT OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE HYDROCHLORIDE ON MURINE NEOPLASMS.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Blood Cells; Carcinoma, Ehrlich Tumor; Cortisone; Cytarabine; Cytosine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
CHEMOTHERAPY OF ADVANCED MOUSE LEUKEMIA L1210: COMPARISON OF METHOTREXATE ALONE AND IN SEQUENTIAL THERAPY.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Leukemia L1210; Methotrexate; Mice; Pharmacology; Research | 1964 |
DEVELOPMENT AND PROPERTIES OF MOUSE LEUKEMIA L1210 RESISTANT TO MIRACIL D.
Topics: Adenine; Animals; Azaguanine; Cyclophosphamide; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Leucovorin; Leukemia L1210; Lucanthone; Mercaptopurine; Methotrexate; Mice; Pharmacology; Proadifen; Pyridoxine; Research; Thioguanine | 1964 |
CYTOGENETICS OF MOUSE LEUKEMIA L1210. I. ASSOCIATION OF A SPECIFIC CHROMOSOME WITH DIHYDROFOLATE REDUCTASE ACTIVITY IN AMETHOPTERIN-TREATED SUBLINES.
Topics: Animals; Biological Assay; Chromosomes; Clinical Enzyme Tests; Cytogenetic Analysis; Leukemia L1210; Methotrexate; Mice; Mutation; Oxidation-Reduction; Oxidoreductases; Pharmacology; Research; Statistics as Topic; Tetrahydrofolate Dehydrogenase | 1965 |
CATALASE ACTIVITY IN MOUSE LEUKEMIA L1210.
Topics: Animals; Blood Cell Count; Blood Chemical Analysis; Catalase; Clinical Enzyme Tests; Hemoglobins; Histocytochemistry; Kidney; Leukemia L1210; Liver; Metabolism; Methotrexate; Mice; Neoplasm Transplantation; Pharmacology; Research; Spleen | 1965 |
THE PHARMACOLOGICAL AND BIOCHEMICAL ACTIVITY OF 4-AMINO-4-DEOXY-10-METHYLPTEROYLASPARTIC ACID.
Topics: Adenine; Amino Acids; Animals; Aspartic Acid; Enzyme Inhibitors; Folic Acid; Formates; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Research | 1965 |
Lectinocytochemical detection of apoptotic murine leukemia L1210 cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Membrane; DNA, Neoplasm; Glycoproteins; Histocytochemistry; Image Cytometry; Leukemia L1210; Methotrexate; Mice; Plant Lectins | 2003 |
Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Deoxyadenosines; Deoxycytidine; Drug Resistance, Neoplasm; Flavonoids; Gemcitabine; Leukemia L1210; Methotrexate; Mice; Piperidines; Tumor Suppressor Protein p53 | 2004 |
[Synthesis of methotrexate-poly (ethylene glycol) conjugate and their anti-tumor activity in vitro].
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Methotrexate; Mice; Polyethylene Glycols; Solubility | 2007 |
Radiosensitivity of drug-resistant L1210 leukemia.
Topics: Animals; Cyclophosphamide; In Vitro Techniques; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Radiotherapy Dosage | 1967 |
Kinetics of cancer cell kill by chemotherapeutic agents in vivo.
Topics: Animals; Cricetinae; Cyclophosphamide; Humans; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Prednisone; Vincristine | 1967 |
Intracellular protein breakdown in the L1210 ascites leukemia.
Topics: Animals; Carbon Isotopes; In Vitro Techniques; Leucine; Leukemia L1210; Methotrexate; Mice; Neoplasm Proteins | 1967 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine | 1967 |
Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Insulin; Leucine; Leukemia L1210; Male; Methotrexate; Mice; Thiourea; Tritium | 1967 |
Effect of methotrexate on NAD kinase activity in leukaemic mice.
Topics: Animals; Leukemia L1210; Liver; Male; Methotrexate; Mice; Phosphotransferases; Spleen | 1967 |
Effect of antimetabolites on kinetic behavior of proliferating cultured L1210 leukemia cells.
Topics: Animals; Antimetabolites; Azaserine; Cell Division; Culture Techniques; Cytarabine; Fluorouracil; Kinetics; Leukemia L1210; Mathematics; Methotrexate | 1967 |
Criteria associated with destruction of leukemia and solid tumor cells in animals.
Topics: Animals; Cricetinae; Cyclophosphamide; Cytarabine; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Urea | 1967 |
[Use of purine rescue pathways by L1210 cells exposed to methotrexate in vitro].
Topics: Animals; Chromatography, Liquid; Hypoxanthines; In Vitro Techniques; Leukemia L1210; Methotrexate; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Pyrimidine Nucleotides | 1982 |
The interaction of carrier-bound methotrexate with L1210 cells.
Topics: Animals; Cells, Cultured; Dextrans; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Serum Albumin, Bovine; Temperature; Uridine | 1980 |
Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells.
Topics: Animals; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Streptococcus pneumoniae | 1980 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Polyglutamic Acid; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1980 |
Biochemical alterations during unperturbed suspension growth of L1210 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; DNA, Neoplasm; Floxuridine; Leukemia L1210; Methotrexate; Mice; Neoplasm Proteins; Phosphoribosyl Pyrophosphate; Ribonucleotides; RNA, Neoplasm | 1981 |
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Topics: Animals; Biological Transport; Deoxyuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Purines; RNA, Neoplasm | 1981 |
Combined interferon--antimetabolite therapy of murine L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Interferons; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Prognosis | 1981 |
A nonfunctional protein in human leukemia cells reacts with antiserum to dihydrofolate reductase from L1210 leukemia cells.
Topics: Animals; Chickens; Epitopes; Humans; Immunodiffusion; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1981 |
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.
Topics: Animals; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; Intestine, Small; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Peptide Biosynthesis; Polyglutamic Acid; Sarcoma 180; Time Factors | 1981 |
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1981 |
Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Head and Neck Neoplasms; Humans; Hypoxanthines; Inosine; Leukemia L1210; Methotrexate; Mice; Nucleosides; Phosphoribosyl Pyrophosphate; Thymidine | 1981 |
Identification of a high-molecular-weight nonfunctional protein in L1210 leukemia cells with common antigenic determinants to dihydrofolate reductase.
Topics: Animals; Antigens, Neoplasm; Cytosol; Epitopes; Immune Sera; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Proteins; Protein Binding; Radioimmunoassay; Tetrahydrofolate Dehydrogenase | 1983 |
Studies on the in vivo synthesis of methotrexate polyglutamates and their efflux properties in normal, proliferative, and neoplastic mouse tissues.
Topics: Animals; Bone Marrow; Carcinoma, Ehrlich Tumor; Intestine, Small; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Mice, Inbred Strains; Peptides; Polyglutamic Acid; Sarcoma 180 | 1983 |
Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Trimetrexate | 1984 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting.
Topics: Animals; Cell Membrane; Cell Survival; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Glycated Serum Albumin; Glycation End Products, Advanced; Hydrogen-Ion Concentration; Lectins; Leukemia L1210; Methotrexate; Mice; Serum Albumin; Thiocyanates | 1984 |
Effect of methotrexate on 5-phosphoribosyl 1-pyrophosphate levels in L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Hypoxanthines; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate; Ribose-Phosphate Pyrophosphokinase; Time Factors | 1980 |
Transport of methotrexate in L1210 cells. Mechanism for inhibition by p-chloromercuriphenylsulfonate and N-ethylmaleimide.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport; Carrier Proteins; Cell Line; Dithiothreitol; Dose-Response Relationship, Drug; Ethylmaleimide; Leukemia L1210; Methotrexate; Mice; Phenylmercury Compounds | 1981 |
Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.
Topics: Animals; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Leukemia P388; Melanoma; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Mitomycins; Neoplasms, Experimental | 1983 |
Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Division; Cells, Cultured; Cytarabine; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Thymidine | 1980 |
Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier.
Topics: Animals; Anions; Biological Transport; Cell Fractionation; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Oxidation-Reduction | 1984 |
A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system.
Topics: Aminopterin; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Division; Drug Resistance; Drug Stability; Genetic Variation; Intracellular Signaling Peptides and Proteins; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasm Proteins; Tritium | 1984 |
Immune rejection mechanisms in murine leukemia. I. Timing of tumor cell rejection process relative to the development of humoral and cell-mediated cytotoxic immune responses.
Topics: Animals; Antibody Formation; Antibody-Dependent Cell Cytotoxicity; Drug Resistance; Female; Graft Rejection; Immunity, Cellular; Immunoglobulin G; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation | 1984 |
Abnormal deoxyuridine suppression as a rapid predictor for antimetabolite chemosensitivity: correlation with in vitro tests of growth inhibition.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Colony-Forming Units Assay; Deoxyuridine; DNA; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Leukemia L1210; Methotrexate; Mice; Ovarian Neoplasms; Tumor Stem Cell Assay | 1984 |
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1984 |
Liposomal methotrexate in the treatment of murine L1210 leukemia.
Topics: Animals; Brain; Leukemia L1210; Liposomes; Methotrexate; Mice; Mice, Inbred Strains | 1983 |
Methotrexate analogues--XVII. Antitumor activity of 4-amino-4-deoxy-N10-methylpteroyl-D,L-homocysteic acid and its dual inhibition of dihydrofolate reductase and folyl polyglutamate synthetase.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases | 1984 |
Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system.
Topics: Alkenes; Animals; Biological Transport; Drug Resistance; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Polyenes; Pyrones; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1984 |
Utilization of an immunostaining technique to demonstrate heterogeneity in the content of dihydrofolate reductase in peripheral blast cells from a patient with acute lymphocytic leukemia.
Topics: Animals; Carcinoma; Cell Line; Clone Cells; Drug Resistance; Histocytochemistry; Humans; Immunoassay; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Mouth Neoplasms; Tetrahydrofolate Dehydrogenase | 1984 |
Potentiation of methotrexate toxicity by dipyridamole.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dipyridamole; DNA Replication; Drug Synergism; Female; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Osteosarcoma; Ovary | 1984 |
Identical efficacy of methotrexate regimens with N5-methyltetrahydrofolate rescue or with leucovorin rescue for treatment of L1210 murine leukemia.
Topics: Animals; Drug Administration Schedule; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Life Expectancy; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Tetrahydrofolates | 1983 |
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine | 1984 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine | 1983 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Irreversible inhibitors of methotrexate transport in L1210 cells. Characteristics of inhibition by an N-hydroxysuccinimide ester of methotrexate.
Topics: Animals; Biological Transport; Kinetics; Leukemia L1210; Methotrexate; Mice; Nitrophenols; Tritium | 1983 |
Analysis of the transport mechanism for methotrexate in L1210 mouse leukemia cells.
Topics: Animals; Biological Transport; HEPES; Leukemia L1210; Methotrexate; Mice; Sucrose | 1983 |
Use of non-physiological buffer systems in the analysis of methotrexate transport in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Buffers; Leukemia L1210; Membrane Potentials; Methotrexate; Mice; Osmolar Concentration | 1983 |
Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyuridine; Dose-Response Relationship, Drug; Fluorouracil; Humans; Leukemia L1210; Melanoma; Methotrexate; Mice; Tritium | 1983 |
Transport routes utilized by L1210 cells for the influx and efflux of methotrexate.
Topics: Animals; Biological Transport; Kinetics; Leukemia L1210; Methotrexate; Mice; Oligomycins; Temperature; Tritium | 1984 |
Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate.
Topics: Animals; Drug Stability; Hot Temperature; Isoelectric Point; Leukemia L1210; Methotrexate; Mice; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1984 |
Probenecid inhibition of methotrexate cytotoxicity in mouse L1210 leukemia cells.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Interactions; Interphase; Leukemia L1210; Methotrexate; Mice; Probenecid | 1984 |
Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate.
Topics: Affinity Labels; Animals; Carrier Proteins; Cell Membrane; Detergents; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolates; Tritium | 1984 |
Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: further evidence for separate influx and efflux systems with different energetic requirements.
Topics: Animals; Azides; Biological Transport, Active; Carrier Proteins; Chlorides; Energy Metabolism; Glucose; Kinetics; Leukemia L1210; Methotrexate; Mice; Models, Biological; Sodium Azide; Tetrahydrofolate Dehydrogenase | 1984 |
Occurrence and significance of D-methotrexate as a contaminant of commercial methotrexate.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Stereoisomerism | 1984 |
A fluorescent analogue of methotrexate as a probe for folate antagonist molecular receptors.
Topics: Animals; Dansyl Compounds; Fluorescence; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1984 |
The use of a fluorescent methotrexate probe to monitor the effects of three vinca alkaloids on a mixed population of parental L1210 and gene-amplified methotrexate-resistant cells by flow cytometry.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Drug Resistance; Flow Cytometry; Fluorescent Dyes; Gene Amplification; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Vinca Alkaloids | 1984 |
Collateral sensitivity of a methotrexate-resistant L1210 cell line to the vinca alkaloids.
Topics: Animals; Cell Line; Cell Survival; Drug Resistance; Gene Amplification; Leukemia L1210; Methotrexate; Mice; Vinblastine; Vinca Alkaloids; Vincristine; Vindesine | 1984 |
The effect of vinca alkaloids in enhancing the sensitivity of a methotrexate-resistant (L1210/R7A) line, studied by flow cytometric and chromosome number analysis.
Topics: Animals; Cell Division; Cell Line; Chromosomes; DNA, Neoplasm; Drug Resistance; Flow Cytometry; Leukemia L1210; Methotrexate; Mice; Polyploidy; Vinblastine; Vinca Alkaloids; Vincristine; Vindesine | 1984 |
[Evaluation of biochemical criteria for sensitivity of tumor cells to methotrexate by means of mathematic simulation].
Topics: Animals; Carcinoma, Ehrlich Tumor; Folic Acid; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Models, Biological; Purines; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
A fluorescent derivative of methotrexate as an intracellular marker for dihydrofolate reductase in L1210 cells.
Topics: Animals; Biological Transport; Drug Resistance; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Protein Binding; Thiocyanates | 1980 |
[Mathematical description and study of the folic acid cycle reactions].
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Folic Acid; Humans; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Mice; Purines; Rats; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
[Effect of methotrexate on oxygen consumption of L1210 cells and their isolated mitochondria].
Topics: Animals; Cell Division; Cells, Cultured; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Mitochondria; Oxygen Consumption | 1981 |
Survival of tumor-bearing mice exposed to heavy water or heavy water plus methotrexate.
Topics: Animals; Cell Line; Deuterium; Female; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasm Transplantation; Probability; Sarcoma, Experimental; Time Factors | 1982 |
Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase | 1983 |
Establishment of dihydrofolate reductase-increased human cell lines and relationship between dihydrofolate reductase levels and gene copy.
Topics: Animals; Cell Line; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Genes; Humans; Leukemia L1210; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase | 1983 |
Structural requirements for anion substrates of the methotrexate transport system in L1210 cells.
Topics: Animals; Anions; Biological Transport; Buffers; In Vitro Techniques; Kinetics; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship; Substrate Specificity | 1983 |
Studies of amino-acid sequence in dihydrofolate reductase from a human methotrexate-resistant cell line KB/6b. Structural and kinetic comparison with mouse L1210 enzyme.
Topics: Amino Acid Sequence; Animals; Cell Line; Chemical Phenomena; Chemistry; Drug Resistance; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1983 |
A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase.
Topics: Animals; Drug Resistance; Kinetics; Leukemia L1210; Methotrexate; Mice; NAD; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase | 1983 |
Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cytoplasmic Granules; Diffusion; Drug Resistance; Folic Acid; Formyltetrahydrofolates; Kinetics; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship; Tetrahydrofolates | 1983 |
Some biochemical characteristics of L1210 cell lines resistant to 6-mercaptopurine and 6-thioguanine and with increased sensitivity to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Resistance; Female; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Ribonucleotides; Tetrahydrofolate Dehydrogenase; Thioguanine | 1982 |
Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Hot Temperature; Leukemia L1210; Liposomes; Metabolic Clearance Rate; Methotrexate; Mice; Pulmonary Surfactants | 1980 |
Cytotoxicity of adriamycin combined with methotrexate against L1210 leukemia in mice.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; Methotrexate; Mice; Time Factors | 1980 |
Inhibition of dihydrofolate reductase by methotrexate: a new look at an old problem.
Topics: Animals; Catalysis; Cells, Cultured; Cysteine; Folic Acid Antagonists; Histidine; Kinetics; Leukemia L1210; Methotrexate; Mice; NADP; Structure-Activity Relationship | 1980 |
Activity of free and carrier-bound methotrexate against transport-deficient and high dihydrofolate dehydrogenase-containing methotrexate-resistant L1210 cells.
Topics: Animals; Biological Transport; Cell Line; Chemistry, Pharmaceutical; Drug Resistance; Female; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Serum Albumin, Bovine; Tetrahydrofolate Dehydrogenase | 1981 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental | 1981 |
Hypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Nimustine; Nitrosourea Compounds; Thioguanine | 1982 |
Purine modulation of methotrexate cytotoxicity in mammalian cell lines.
Topics: Animals; Cell Line; Cell Survival; Deoxyribonucleotides; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Melanoma; Methotrexate; Mice; Purines | 1982 |
Effect of [3H]methotrexate impurities on apparent transport of methotrexate by a sensitive and resistant L1210 cell line.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Animals; Biological Transport; Drug Resistance; Glutamates; Kinetics; Leukemia L1210; Methotrexate; Mice; para-Aminobenzoates | 1980 |
Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Leucovorin; Leukemia L1210; Methotrexate; Tetrahydrofolate Dehydrogenase | 1980 |
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
Topics: Animals; Bone Marrow; Cell Division; Clone Cells; Culture Media; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Thymidine | 1981 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine | 1980 |
Anion exchange mechanism for transport of methotrexate in L1210 cells.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Anions; Biological Transport; Cell Membrane; Ion Exchange; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phosphates | 1981 |
Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to a third space body compartment.
Topics: Animals; Bone Marrow Diseases; Female; Injections; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Pleura; Polylysine; Serum Albumin, Bovine | 1981 |
Characterization of the methotrexate transport defect in a resistant L 1210 lymphoma cell line.
Topics: Animals; Azides; Biological Transport; Drug Resistance; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mutation; Tetrahydrofolate Dehydrogenase | 1981 |
Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Fluorouracil; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Time Factors | 1981 |
Clinical use of methotrexate--with emphasis on use of high doses.
Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Humans; Infant; Injections, Spinal; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice | 1981 |
Two-compartment behavior during transport of folate compounds in L1210 cell plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mathematics; Methotrexate; Mice; Models, Biological; Tritium | 1982 |
Effect of leukemia and methotrexate on digestive enzymes in the jejunum of mice.
Topics: Alkaline Phosphatase; alpha-Glucosidases; Animals; Disaccharidases; Female; Jejunum; Leukemia L1210; Methotrexate; Mice; Sucrase | 1981 |
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Membranes; Methotrexate; Mice; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1982 |
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Formyltetrahydrofolates; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1982 |
Methotrexate cytotoxicity for L5178Y/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Administration Schedule; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Models, Biological; Time Factors | 1982 |
Potential anticancer agents. XXIII. 1. Qualitative structure--activity relationship in the "classical" antifolates area.
Topics: Animals; Carcinoma 256, Walker; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1982 |
Potential anticancer agents. XXIII. 2. Quantitative structure--activity relationships (QSAR) in the "classical" antifolates area.
Topics: Animals; Folic Acid Antagonists; Lethal Dose 50; Leukemia L1210; Methotrexate; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1982 |
Intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in L1210 cells.
Topics: Animals; Anions; Azides; Biological Transport, Active; Glucose; Kinetics; Leukemia L1210; Methotrexate; Mice; Phosphates; Sodium | 1982 |
Further studies stereospecificity at carbon 6 for membrane transport of tetrahydrofolates. Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells.
Topics: Animals; Biological Transport; Cell Membrane; Leukemia L1210; Methotrexate; Mice; Stereoisomerism; Tetrahydrofolates | 1982 |
Diazoketone and chloromethylketone analogs of methotrexate as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Leukemia L1210; Methotrexate; Mice; Thymidylate Synthase | 1982 |
Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Biological Transport; Energy Metabolism; Folic Acid; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms; Pterins; Tetrahydrofolate Dehydrogenase | 1982 |
Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA; Flow Cytometry; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mitochondria; Rhodamines; Xanthenes | 1982 |
A new fluorescent dihydrofolate reductase probe for studies of methotrexate resistance.
Topics: Animals; Cell Survival; Drug Resistance; Flow Cytometry; Fluorescent Dyes; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1982 |
High-pressure liquid chromatography--ultraviolet analysis of intracellular nucleotides.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Count; Cell Extracts; Cell Line; Chromatography, High Pressure Liquid; Leukemia L1210; Methotrexate; Mice; Nucleotides; Purine Nucleotides; Pyrimidine Nucleotides; Spectrophotometry, Ultraviolet; Tissue Extracts | 1982 |
Enhancement of 6-thioguanine cytotoxic activity with methotrexate.
Topics: Animals; Carbon Radioisotopes; Cell Survival; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Kinetics; Leukemia L1210; Methotrexate; Mice; Thioguanine | 1982 |
Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage.
Topics: Animals; Cell Line; Cell Survival; Drug Resistance; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mutation; Purines; Thymidine | 1981 |
Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cytarabine; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Methylthioinosine; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Thioguanine | 1981 |
Collateral sensitivity to methotrexate and dichloromethotrexate of cultured lymphocytic leukemia L1210 cells resistant to 6-mercaptopurine.
Topics: Animals; Cell Division; Cells, Cultured; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate | 1982 |
Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase.
Topics: Aminopterin; Animals; Cell Division; Cell Membrane; Cells, Cultured; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice | 1980 |
Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.
Topics: Animals; Biological Transport; Cell Membrane; Computers; Drug Resistance; Kinetics; Leukemia L1210; Male; Methotrexate; Methyltransferases; Mice; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thymidylate Synthase | 1981 |
Microwave treatment of intracerebral L1210 leukemia: schedule-dependent partial reversal of the effects of methotrexate.
Topics: Animals; Brain Neoplasms; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Microwaves; Neoplasms, Experimental | 1981 |
Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport.
Topics: Animals; Biological Transport, Active; Bone Marrow; Female; Kidney; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Mice, Inbred Strains; Probenecid; Sarcoma 180 | 1981 |
Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Phenotype; Tetrahydrofolate Dehydrogenase | 1981 |
Inhibition of DNA synthesis and enhancement of the uptake and action of methotrexate by low-power-density microwave radiation in L1210 leukemia cells.
Topics: Animals; Biological Transport, Active; DNA, Neoplasm; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Microwaves | 1980 |
Transport of methotrexate in L1210 cells: effect of ions on the rate and extent of uptake.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Calcium; Chlorides; Kinetics; Leukemia L1210; Magnesium; Methotrexate; Mice; Phosphates; Sodium | 1980 |
Irreversible inactivation of the methotrexate transport system of L1210 cells by carbodiimide-activated substrates.
Topics: Animals; Biological Transport; Dicyclohexylcarbodiimide; Ethyldimethylaminopropyl Carbodiimide; Kinetics; Leukemia L1210; Methotrexate; Mice | 1980 |
Synchronization of L1210 leukemia with hydroxyurea infusion and the effect of subsequent pulse dose chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cytarabine; Doxorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hydroxyurea; Interphase; Leukemia L1210; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors; Transplantation, Homologous | 1980 |
Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.
Topics: Animals; Cell Survival; Female; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Thymidylate Synthase | 1980 |
Binding properties of the 5-methyltetrahydrofolate/methotrexate transport system in L1210 cells.
Topics: Animals; Anions; Binding Sites; Biological Transport; Carrier Proteins; Cell Membrane; Kinetics; Leukemia L1210; Methotrexate; Mice; Protein Binding; Tetrahydrofolates | 1980 |
Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Kinetics; Leukemia L1210; Methotrexate; Mice | 1980 |
Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Pyrimethamine | 1980 |
Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia.
Topics: Animals; Cyclophosphamide; Drug Interactions; Fluorouracil; Leukemia L1210; Liver; Male; Methotrexate; Mice; Mixed Function Oxygenases; Oxidoreductases; Semustine | 1980 |
Effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on pools of deoxyribonucleoside triphosphates in L1210 ascites cells.
Topics: Animals; Ascites; Cytarabine; Deoxyribonucleotides; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice | 1981 |
A thin-layer chromatographic method for separation of thymidine and deoxyuridine nucleotides.
Topics: Animals; Chromatography, Thin Layer; Deoxyuracil Nucleotides; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Thymine Nucleotides | 1980 |
Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Probenecid; Sarcoma, Experimental | 1981 |
5'-Cholesteryl-phosphorothioate oligodeoxynucleotides: potent inhibition of methotrexate transport and antagonism of methotrexate toxicity in cells containing the reduced-folate carrier.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cholesterol; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Oligodeoxyribonucleotides; Reduced Folate Carrier Protein; Thionucleotides; Tumor Cells, Cultured | 1995 |
Comparison of transport properties of the reduced folate carrier and folate receptor in murine L1210 leukemia cells.
Topics: Animals; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Probenecid; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Tumor Cells, Cultured | 1995 |
Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
Topics: Animals; Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Peptide Synthases; Polyglutamic Acid; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase | 1995 |
Influence of 2-chloro-2'-deoxyadenosine alone and in combination with cyclophosphamide or methotrexate on murine leukemia L1210.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Neoplasm Transplantation | 1994 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line.
Topics: Alleles; Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; Base Sequence; Carrier Proteins; CHO Cells; Cloning, Molecular; Codon; Conserved Sequence; Cricetinae; DNA Primers; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Receptors, Cell Surface; Recombinant Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured | 1995 |
Retentiveness of methotrexate polyglutamates in cultured L1210 cells. Evidence against a role for mediated plasma membrane transport outward.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Kinetics; Leukemia L1210; Methotrexate; Polyglutamic Acid; Tritium; Tumor Cells, Cultured | 1993 |
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
Topics: Alkenes; Animals; Biological Transport; Carrier Proteins; Energy Metabolism; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Ions; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyenes; Probenecid; Pyrones; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Temperature; Transfection; Tumor Cells, Cultured | 1995 |
Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells.
Topics: Adenosine Triphosphatases; Animals; Cell Line; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice | 1995 |
Activation and cytotoxicity of 2-alpha-aminoacyl prodrugs of methotrexate.
Topics: Aminopeptidases; Animals; Blood; Buffers; Cell Division; Cell Survival; Drug Stability; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Prodrugs; Pyroglutamyl-Peptidase I | 1995 |
ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. Properties of two distinct transport systems in inside-out vesicles from L1210 cells and a variant subline with altered efflux of methotrexate and cholate.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Cholic Acid; Cholic Acids; Clone Cells; Glutathione; Kinetics; Leukemia L1210; Methotrexate; Mice; Tritium; Tumor Cells, Cultured | 1995 |
Activation by peptidases and cytotoxicity of 2-(L-alpha-aminoacyl) prodrugs of methotrexate.
Topics: Acylation; Amino Acids; Aminopeptidases; Animals; Bacillus; CD13 Antigens; Cell Survival; Endopeptidases; Folic Acid Antagonists; Kidney; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Prodrugs; Pyroglutamyl-Peptidase I; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |
Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice.
Topics: Animals; Epithelium; Female; Folic Acid; Intestinal Mucosa; Leucovorin; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Peritoneum; Tumor Cells, Cultured | 1994 |
A methodology for finding optimal dosage levels in multi-drug treatment interactions.
Topics: Algorithms; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Confidence Intervals; Cyclophosphamide; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Drug Therapy, Computer-Assisted; Drug-Related Side Effects and Adverse Reactions; Imidazoles; Leukemia L1210; Methotrexate; Mice; Models, Biological; Pharmaceutical Preparations; Proportional Hazards Models; Regression Analysis; Survival Rate | 1994 |
Growth kinetics of L1210 leukemic cells exposed to different concentration courses of methotrexate in vitro.
Topics: Animals; Cell Division; Kinetics; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1994 |
Synergistic action of 2-chlorodeoxyadenosine and cyclophosphamide on murine leukemias L1210 and P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Drug Synergism; Female; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred DBA | 1993 |
Functional implications from the effects of 1-chloro-2,4-dinitrobenzene and ethacrynic acid on efflux routes for methotrexate and cholate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Anions; Biological Transport; Cholic Acid; Cholic Acids; Dinitrochlorobenzene; Ethacrynic Acid; Glutathione; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1994 |
Sustained-release methotrexate for intracavitary chemotherapy.
Topics: Animals; Cell Transplantation; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Injections, Intraperitoneal; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation | 1994 |
l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate doses.
Topics: Animals; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Tetrahydrofolates | 1993 |
A unified framework for using neural networks to build QSARs.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Molecular Structure; Neural Networks, Computer; Progesterone; Regression Analysis; Structure-Activity Relationship; Triazines | 1993 |
Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
Topics: Animals; Cell Division; Intestine, Small; Leukemia L1210; Lipids; Malabsorption Syndromes; Male; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Neoplasm Transplantation; Proteins; Sarcoma 180; Vitamin A | 1993 |
Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Chromatography, Affinity; DNA Primers; DNA, Neoplasm; Drug Resistance; Enzyme Stability; Escherichia coli; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; NADP; Point Mutation; Polymerase Chain Reaction; Protein Conformation; Tetrahydrofolate Dehydrogenase; Time Factors | 1993 |
Synthesis and preliminary biological evaluation of analogues of 5,8-dideazaisofolic acid and its 2-desamino-2-methyl derivative containing fluorine at position five.
Topics: Animals; Cell Survival; Fluorine; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Quinazolines; Structure-Activity Relationship; Swine; Tumor Cells, Cultured | 1993 |
Analogues of classical antifolates bearing naphthoyl in place of benzoyl.
Topics: Adenocarcinoma; Animals; Cell Line; Cell Survival; Computer Graphics; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Promyelocytic, Acute; Mammary Neoplasms, Experimental; Methotrexate; Mice; Models, Molecular; Peptide Synthases; Sarcoma 180; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Antitumor efficacy of classical non-polyglutamylatable antifolates that inhibit dihydrofolate reductase.
Topics: Aminopterin; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred Strains; Tumor Cells, Cultured | 1993 |
Transformation of an L-cell line with the DNA coding for the reduced-folate/methotrexate transporter protein from a CCRF-CEM human leukemia cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Line; Cell Transformation, Neoplastic; Clone Cells; DNA, Neoplasm; Folate Receptors, GPI-Anchored; Humans; Kinetics; L Cells; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Transfection; Tumor Cells, Cultured | 1993 |
Effect of vitamin A on methotrexate cytotoxicity in L1210 murine leukemia cells in culture.
Topics: Animals; Bone Marrow; Cell Division; DNA, Neoplasm; Drug Interactions; Leukemia L1210; Leukocyte Count; Liver; Male; Methotrexate; Neoplasm Proteins; Rats; Rats, Wistar; RNA, Neoplasm; Tumor Cells, Cultured; Vitamin A | 1993 |
Altered expression of unidirectional extrusion routes for methotrexate and cholate in an efflux variant of L1210 cells.
Topics: Animals; Cell Division; Cholic Acids; Drug Interactions; Drug Tolerance; Exocytosis; Leukemia L1210; Methotrexate; Mice; Probenecid; Sulfobromophthalein; Tumor Cells, Cultured | 1993 |
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Colonic Neoplasms; Female; Humans; Indoles; Isoindoles; Leucovorin; Leukemia L1210; Leukemia, T-Cell; Methotrexate; Quinazolines; Structure-Activity Relationship; Subrenal Capsule Assay; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Southern; Cisplatin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia L1210; Methotrexate; Mice; Peptide Synthases; Tetrahydrofolate Dehydrogenase; Time Factors; Tumor Cells, Cultured | 1996 |
Correlation of altered tyrosine phosphorylation with methotrexate resistance in a cisplatin-resistant subline of L1210 cells.
Topics: Affinity Labels; Animals; Biological Transport, Active; Blotting, Western; Cisplatin; Clone Cells; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Leukemia L1210; Membrane Proteins; Methotrexate; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Tumor Cells, Cultured | 1996 |
Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antimetabolites, Antineoplastic; Bleomycin; DNA; DNA Damage; Fluorouracil; Hydrogen Peroxide; Leukemia L1210; Methotrexate; Methylnitrosourea; Mice; Mutagenicity Tests; Mutagens; Subcellular Fractions; Tumor Cells, Cultured | 1996 |
Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects.
Topics: Animals; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Peptide Synthases; Polyglutamic Acid; Receptors, Cell Surface; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1996 |
[The effect of benzylpenicillin and doxycycline on toxicity and antineoplastic action of cyclophosphamide and methotrexate in mice].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Doxycycline; Drug Interactions; Lethal Dose 50; Leukemia L1210; Male; Methotrexate; Mice; Penicillin G | 1992 |
Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells.
Topics: Animals; Cytarabine; Deoxycytidine Kinase; Etoposide; Leukemia L1210; Methotrexate; Mice; Phosphorylation | 1996 |
Variant GPI structure in relation to membrane-associated functions of a murine folate receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; DNA Primers; Ethanolamine; Ethanolamines; Folate Receptors, GPI-Anchored; Glycosylphosphatidylinositols; Humans; Kidney; Leucovorin; Leukemia L1210; Methotrexate; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Polymerase Chain Reaction; Radioligand Assay; Receptors, Cell Surface; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolates; Transfection; Tritium; Tumor Cells, Cultured | 1996 |
pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Tumor Cells, Cultured | 1997 |
Biotin derivatives of folate compounds: synthesis and utilization for visualization and affinity purification of folate transport proteins.
Topics: Animals; Bacterial Proteins; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fluorescein; Fluoresceins; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Microscopy; Molecular Structure; Receptors, Cell Surface; Sepharose; Tumor Cells, Cultured | 1997 |
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
Topics: Animals; Anions; Biological Transport; Carrier Proteins; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyglutamic Acid | 1997 |
Selective tumor apoptosis by MF13, L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester, a new sarcolysin containing tripeptide.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; DNA Fragmentation; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Lethal Dose 50; Leukemia; Leukemia L1210; Lymphoma; Melphalan; Methotrexate; Mice; Neoplasms; Oligopeptides; Tumor Cells, Cultured | 1997 |
A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within
Topics: Amino Acid Sequence; Aminopterin; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Conformation; Sarcoma 180; Sequence Homology, Amino Acid; Tumor Cells, Cultured | 1998 |
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
Topics: Amino Acid Substitution; Animals; Anions; Binding Sites; Biological Transport, Active; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Glutamic Acid; Kinetics; Leukemia L1210; Lysine; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Protein Structure, Secondary; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; DNA Mutational Analysis; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phenotype; Point Mutation; Pteroylpolyglutamic Acids; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Female; Humans; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1997 |
Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Ammonium Chloride; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Methotrexate; Mice; Monensin; Nigericin; Receptors, Cell Surface; Tumor Cells, Cultured; Valinomycin | 1998 |
Electrical stimulation prolongs the survival days of leukemic mice treated with methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Electric Stimulation; Leukemia L1210; Male; Metabolic Clearance Rate; Methotrexate; Mice; Mice, Inbred DBA; Specific Pathogen-Free Organisms; Stress, Psychological; Survival Rate; Time Factors; Tumor Cells, Cultured | 1999 |
Pattern of mutations that results in loss of reduced folate carrier function under antifolate selective pressure augmented by chemical mutagenesis.
Topics: Animals; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 1999 |
Collateral methotrexate resistance in cisplatin-selected murine leukemia cells.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Resistance, Neoplasm; Leukemia L1210; Methotrexate; Mice; Phosphorylation; Tyrosine | 1999 |
Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.
Topics: Amino Acid Substitution; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Chlorides; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Drug Resistance, Neoplasm; Kinetics; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Phenotype; Phenylalanine; Reduced Folate Carrier Protein; Serine; Transfection; Tumor Cells, Cultured | 1999 |
Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
Topics: Amino Acid Substitution; Animals; Anions; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Folic Acid; Glutamic Acid; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Reduced Folate Carrier Protein; Tetrahydrofolates; Transfection; Tumor Cells, Cultured | 2000 |
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
Topics: 3' Untranslated Regions; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; DNA Primers; DNA, Complementary; DNA, Neoplasm; Folic Acid; Humans; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Reduced Folate Carrier Protein; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured | 2000 |
Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antimetabolites, Antineoplastic; Carcinogens; Cricetinae; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Methylnitrosourea; Mice; Molecular Sequence Data; Peptide Synthases; Protein Conformation; Sequence Alignment; Structure-Activity Relationship; Tetrahydrofolates; Transfection | 2000 |
Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells.
Topics: Animals; Base Sequence; Biological Transport, Active; Carrier Proteins; Cell Line; DNA Primers; Folic Acid; Gene Expression; Genes, myc; Genes, ras; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Rats; Reduced Folate Carrier Protein; Transfection | 2000 |
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; DNA, Complementary; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Tetrahydrofolates; Transfection | 2000 |
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Prostaglandins A | 2000 |
Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells.
Topics: Animals; Biological Transport; Carrier Proteins; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis; Recombinant Proteins; Thiamine; Thiamine Pyrophosphate; Transfection; Tumor Cells, Cultured | 2001 |
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.
Topics: Animals; Biological Transport; Carrier Proteins; Dose-Response Relationship, Drug; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Thiamine; Thiamine Monophosphate; Tumor Cells, Cultured | 2002 |
Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells.
Topics: Animals; Binding Sites; Cells, Cultured; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Leukemia L1210; Methotrexate; NADP; Protein Binding; Protein Conformation; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1975 |
Interaction of 1,N6-ethenoadenine derivatives of triphosphopyridine and reduced triphosphopyridine nucleotides with dihydrofolate reductase from amethopterin-resistant L1210 cells.
Topics: Animals; Binding Sites; Drug Resistance; Kinetics; Leukemia L1210; Methotrexate; Mice; NADP; Oxidation-Reduction; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1976 |
Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.
Topics: Animals; Chromatography, Affinity; Circular Dichroism; Drug Resistance; Leukemia L1210; Methotrexate; Molecular Weight; NADP; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Tryptophan | 1977 |
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1977 |
Folate uptake in L1210 cells: mediation by an adenine transport system.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Biological Transport, Active; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice | 1979 |
Increase of phosphoribosylpyrophosphate levels in cultured L1210 leukemia cells exposed to methotrexate.
Topics: Animals; Dose-Response Relationship, Drug; Hypoxanthines; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase | 1979 |
Effects of entrapment in liposomes on the distribution, degradation and effectiveness of methotrexate in vivo.
Topics: Animals; Guinea Pigs; Haplorhini; Kinetics; Leukemia L1210; Liposomes; Liver; Macaca fascicularis; Metabolic Clearance Rate; Methotrexate; Pharmaceutical Vehicles; Spleen; Tissue Distribution | 1978 |
Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
Topics: Animals; Cells, Cultured; Floxuridine; Folic Acid; Leukemia L1210; Methotrexate | 1978 |
[Tomizine--a new inhibitor of folate metabolism enzymes possessing an antitumor activity].
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasms, Experimental; Rats; Sarcoma 37; Sarcoma, Experimental; Thiazines | 1975 |
Combination chemotherapy of L1210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents.
Topics: Animals; Cell Survival; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Mesylates; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Organometallic Compounds; Platinum; Propylamines; Vincristine | 1976 |
Transport of methotrexate and other folate compounds: components, mechanism and regulation by cyclic nucleotides.
Topics: Animals; Bacterial Proteins; Biological Transport, Active; Cyclic AMP; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Molecular Weight; Protein Binding | 1976 |
Cyclic adenosine 3':5'-monophosphate and methotrexate transport in L1210 cells.
Topics: Animals; Azides; Biological Transport, Active; Cells, Cultured; Cyclic AMP; Glucose; Leukemia L1210; Methotrexate; Prostaglandins E; Theophylline; Xanthines | 1978 |
Effect of modification of plasma membrane fatty acid composition on fluidity and methotrexate transport in L1210 murine leukemia cells.
Topics: Animals; Biological Transport, Active; Cell Membrane; Dietary Fats; Electron Spin Resonance Spectroscopy; Fatty Acids; Kinetics; Leukemia L1210; Male; Membrane Fluidity; Membrane Lipids; Methotrexate; Mice; Mice, Inbred DBA | 1979 |
Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Drug Synergism; Humans; In Vitro Techniques; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice | 1979 |
Vincristine-methotrexate combination chemotherapy and the influence of weight loss on experimental tumour growth.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Starvation; Vincristine | 1979 |
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues.
Topics: Animals; Bone Marrow; Bone Marrow Cells; DNA; Drug Interactions; Drug Therapy, Combination; Hypoxanthines; Intestinal Mucosa; Intestines; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Purines; Pyrimidines; Thymidine | 1977 |
High-dose methotrexate therapy with citrovorum factor: a pharmacologic perspective in murine tumor models.
Topics: Animals; DNA; DNA, Neoplasm; Drug Therapy, Combination; Intestine, Small; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma 180; Time Factors | 1977 |
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
Topics: Allopurinol; Animals; Drug Synergism; Female; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Purines; Pyrimidines; Thymidine; Time Factors | 1977 |
Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.
Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Sarcoma 180; Time Factors | 1978 |
Modulation versus rescue of antimetabolite toxicity by salvage metabolites administered by continuous infusion.
Topics: Animals; Drug Therapy, Combination; Duodenal Diseases; Female; Infusions, Parenteral; Inosine; Lethal Dose 50; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1978 |
An apparent relationship between responsiveness to folinic acid protection from methotrexate cytotoxicity and uptake of 5-methyltetrahydrofolate in a series of murine cell lines.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolates | 1979 |
The isolation of dihydrofolate reductases by affinity chromatography on folate-sepharose.
Topics: Animals; Cell Line; Chromatography, Affinity; Folic Acid; Humans; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Leukocytes; Methotrexate; Mice; Sepharose; Tetrahydrofolate Dehydrogenase | 1977 |
[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro].
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Glucose; Glycolysis; Lactates; Leukemia L1210; Methotrexate | 1978 |
Different effects of vincristine on methotrexate uptake by L1210 cells and mouse intestinal epithelia in vitro and in vivo.
Topics: Animals; Biological Transport, Active; Drug Synergism; Drug Therapy, Combination; Epithelium; Female; In Vitro Techniques; Intestine, Small; Leukemia L1210; Male; Methotrexate; Mice; Vincristine | 1979 |
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
Topics: Animals; Cells, Cultured; Drug Administration Schedule; Drug Synergism; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Ribonucleotides; RNA, Neoplasm; Thymidylate Synthase | 1979 |
Thymidine 5'-O-pivaloate. A prodrug derivative of thymidine with potential applications in high-dose methotrexate therapy.
Topics: Animals; DNA; Drug Therapy, Combination; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Pentanoic Acids; Thymidine | 1979 |
Methotrexate-induced changes in the levels of 1-beta-D-arabinofuranosylcytosine triphosphate in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Deoxycytidine Kinase; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1979 |
Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine.
Topics: Animals; Cell Division; Cell Line; Cells, Cultured; Deoxyribonucleotides; Dose-Response Relationship, Drug; Humans; Leukemia L1210; Methotrexate; Ribonucleotides; Thymidine | 1979 |
Photoinactivation of the methotrexate transport system of L1210 cells by 8-azidoadenosin 5'-monophosphate.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Azides; Biological Transport; Carrier Proteins; Kinetics; Leukemia L1210; Methotrexate; Mice; Phosphates; Photochemistry; Thiamine Pyrophosphate | 1979 |
Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro.
Topics: Animals; Cell Survival; Formyltetrahydrofolates; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolates; Time Factors | 1979 |
Methotrexate di-n-butyl ester effects on thymidine metabolism.
Topics: Animals; Biological Transport; Cells, Cultured; DNA-Directed DNA Polymerase; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymidine Kinase | 1979 |
Methotrexate (MTX) effect on pancreatic enzymes in leukemic mice.
Topics: Amylases; Animals; Chymotrypsin; Dose-Response Relationship, Drug; Female; Leukemia L1210; Lipase; Methotrexate; Mice; Pancreas; Trypsin | 1979 |
Studies of a methotrexate binding protein fraction from L1210 lymphocyte plasma membranes.
Topics: Animals; Binding Sites; Cell Membrane; Chromatography, Affinity; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Protein Binding | 1979 |
Reactivation of dihydrofolate reductase inhibted by methotrexate or aminopterin.
Topics: Aminopterin; Animals; Cell Line; Computers; Deoxyuridine; Dialysis; Enzyme Activation; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Protein Binding; Tetrahydrofolate Dehydrogenase | 1977 |
Comparison of the cytotoxicity of methotrexate and aminopterin on methotrexate resistant murine lymphoma cells in vitro.
Topics: Aminopterin; Animals; Cell Line; Cell Survival; Drug Resistance; Leukemia L1210; Lymphoma; Methotrexate; Neoplasms, Experimental | 1978 |
Effect of interaction between methotrexate and dihydrofolate reductase on DNA synthesis in L1210 cells in vitro.
Topics: Animals; DNA; Female; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Receptors, Drug; Tetrahydrofolate Dehydrogenase | 1978 |
Methotrexate induced alteration of glycolysis in L1210 cells in vitro.
Topics: Animals; Cells, Cultured; Fructose-Bisphosphate Aldolase; Glucose; Glucose-6-Phosphate Isomerase; Glucosephosphate Dehydrogenase; Lactates; Leukemia L1210; Methotrexate; Pyruvate Kinase | 1978 |
Combination chemotherapy in sequence for the treatment of L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Teniposide; Therapeutic Equivalency | 1978 |
[Transplantability, development and methotrexate sensitivity of mouse leukemia L1210 resistant to olivomycin].
Topics: Animals; Drug Resistance; Immunization; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Olivomycins; Time Factors | 1978 |
Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells.
Topics: Animals; Binding Sites; Binding, Competitive; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1978 |
Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymidine | 1978 |
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180 | 1978 |
Lack of therapeutic synergism between vincristine and methotrexate in L1210 murine leukemia in vivo.
Topics: Animals; Ascitic Fluid; Biological Transport; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Vincristine | 1978 |
Growth inhibitory, transport and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of methotrexate in L1210 leukemia cells in vitro.
Topics: Animals; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Leukemia L1210; Methotrexate; Mice | 1978 |
Potential anticancer agents. 16. Methotrexate analogues with a modified peptide side chain.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Leukemia L1210; Methotrexate; Mice; Rats; Structure-Activity Relationship | 1978 |
Potential anticancer agents. 17. Analogues of methotrexate with a tripeptide side chain.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Leukemia L1210; Methotrexate; Mice; Rats; Structure-Activity Relationship | 1978 |
DIVEMA-methotrexate: immune-adjuvant role of polymeric carriers linked to antitumor agents.
Topics: Adjuvants, Immunologic; Animals; Antigens, Neoplasm; Cytotoxicity, Immunologic; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; Lung Neoplasms; Macrophages; Male; Methotrexate; Mice; Neoplasms, Experimental; Polymers; Pyran Copolymer | 1978 |
Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
Topics: Animals; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Kinetics; Leukemia L1210; Methotrexate; Mice; Models, Biological | 1978 |
Rationale of chemotherapeutic adjuvant treatment.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Humans; Leukemia L1210; Lomustine; Mercaptopurine; Methotrexate; Mice; Neoplasms | 1978 |
Interrelationship between chemotherapy and immunotherapy in the treatment of disseminated disease.
Topics: Animals; Carmustine; Dacarbazine; Humans; Immunity; Immunotherapy; Leukemia L1210; Methotrexate; Mice; Mice, Inbred BALB C; Neoplasms | 1978 |
Folate analog transport by plasma membrane vesicles isolated from L1210 leukemia cells.
Topics: Aminopterin; Animals; Biological Transport; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1979 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Tegafur | 1976 |
Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.
Topics: Animals; Asparaginase; Asparagine; Autoradiography; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Haplorhini; L Cells; Leukemia L1210; Methotrexate; Neoplasms, Experimental | 1975 |
A direct ligand-binding radioassay for the measurement of methotrexate in tissues and biological fluids.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Folic Acid; Humans; Leukemia L1210; Mercaptoethanol; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; NADPH-Ferrihemoprotein Reductase; Radioligand Assay; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase | 1975 |
Synthesis of N-10-methyl-4-thiofolic acid and related compounds.
Topics: Animals; Carcinoma; Columbidae; Enterococcus faecalis; Folic Acid Antagonists; Humans; Leukemia L1210; Liver; Methotrexate; Mice; Mouth Neoplasms; Thiones | 1975 |
Synthesis of a fluorescent derivative of amethopterin,.
Topics: Animals; Biological Transport; Depression, Chemical; Diamines; Fluoresceins; Fluorescence; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Spectrophotometry, Ultraviolet; Thiocyanates | 1975 |
Methotrexate analogs. 6. Replacement of glutamic acid by various amino acid esters and amines.
Topics: Animals; Enterococcus faecalis; Glutamates; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Structure-Activity Relationship | 1975 |
Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells.
Topics: Animals; Binding Sites; Folic Acid Antagonists; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Peptide Biosynthesis; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase | 1977 |
High molecular weight derivatives of methotrexate as chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; Intracellular Fluid; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Molecular Weight; Serum Albumin, Radio-Iodinated; Time Factors | 1977 |
Reduced forms of aminopterin and methotrexate in L1210 lymphoma.
Topics: Aminopterin; Animals; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1977 |
[Correlation between the effects of cytostatic agents on leukemia L 1210 in vivo and in the short term test in vitro (author's transl)].
Topics: Animals; Cell Count; Culture Techniques; Deoxyuridine; Doxorubicin; Female; Leucine; Leukemia L1210; Methotrexate; Mice; Thymidine; Time Factors; Uridine; Vinblastine | 1977 |
Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells.
Topics: Aminopterin; Animals; Biological Transport, Active; Epithelium; In Vitro Techniques; Intestine, Small; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Structure-Activity Relationship | 1977 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Podophyllotoxin; Vincristine | 1976 |
Effect of methotrexate on the cell cycle of L1210 leukemia.
Topics: Animals; Cell Division; DNA, Neoplasm; Leukemia L1210; Methotrexate; Mitotic Index; Thymidine | 1976 |
Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux.
Topics: Animals; Biological Transport, Active; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Mice; Mice, Inbred Strains; Models, Biological | 1976 |
The value of adriamycin in overcoming resistance to methotrexate in tissue culture.
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Dinitrophenols; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Methotrexate; Temperature | 1976 |
Electronic volume analysis of L1210 chemotherapy.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Count; Cell Division; Cell Survival; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Electronics; Female; Leukemia L1210; Methotrexate; Mice; Time Factors; Vincristine | 1976 |
Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.
Topics: Animals; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Intestine, Small; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1976 |
Deveopment of resistance to combinations of six antimetabolites in mice with L1210 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Thioguanine; Thioinosine | 1976 |
Experimental and clinical studies on nucleoside analogs as antitumor agents.
Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leukemia, Experimental; Male; Methotrexate; Mice; Nasopharyngeal Neoplasms; Structure-Activity Relationship | 1975 |
Preparation and therapeutic potential of rabbit antisera with "directed" specificities for mouse leukemias.
Topics: Animals; Antigens, Neoplasm; Drug Resistance; Female; Hemagglutination; Immune Sera; Immunization; Immunization, Passive; Leukemia L1210; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred DBA; Rabbits | 1976 |
The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects.
Topics: Allopurinol; Animals; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Thymidine | 1975 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides | 1975 |
Methotrexate-thymidine treatment of murine leukemia.
Topics: Allopurinol; Animals; Drug Evaluation, Preclinical; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine | 1975 |
New approach to antifolate treatment of certain cancers as demonstrated in tissue culture.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cells, Cultured; Female; Fibroblasts; Humans; Leucovorin; Leukemia L1210; Leukemia, Myeloid; Liver; Methotrexate; Mice; Neoplasms, Experimental; Rats; Tetrahydrofolates | 1975 |
Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.
Topics: Animals; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Female; Intestine, Small; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Time Factors | 1976 |
Offsetting toxicity of antineoplastic agents.
Topics: Animals; Biological Products; Bone Marrow; Bone Marrow Cells; Carcinoma, Krebs 2; Cells, Cultured; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mitosis; Saccharomyces cerevisiae | 1975 |
Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cephalosporins; Dexamethasone; DNA; DNA, Neoplasm; Fluorouracil; Folic Acid; Glucocorticoids; Humans; Hydrocortisone; Idoxuridine; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Prednisolone; Prednisone; Vincristine | 1975 |
Stoichiometric inhibition of mammalian dihydrofolate reductase by the gamma-glutamyl metabolite of methotrexiate, 4-amino-4-deoxy-N-10-methylpteroylglutamyl-gamma-glutamate.
Topics: Animals; Cell Division; Cells, Cultured; Chromatography, Gel; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1975 |
The enhanced cytotoxicity of combinations of 1-beta-D-arabinofuranosylcytosine and methotrexate.
Topics: Animals; Cell Division; Cytarabine; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; In Vitro Techniques; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Spleen; Time Factors | 1975 |
Effects of allopurinol on the therapeutic efficacy of methotrexate.
Topics: Allopurinol; Animals; Chick Embryo; Female; Hypoxanthines; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1975 |
Effect of 3-[4-amino-2-methyl-5-pyrimidinyl)ethyl[-1(2-chloroethyl)-1-nitrosourea hydrochloride on lymphoid leukemia L-1210.
Topics: Administration, Oral; Animals; Carbazilquinone; Cyclophosphamide; Daunorubicin; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Lomustine; Male; Methotrexate; Mice; Mitomycins; Nitrogen Mustard Compounds; Nitrosourea Compounds; Time Factors; Triaziquone | 1975 |
[Effect of methotrexate on the leukemic cell cycle in mouse ascitic leukemia L1210].
Topics: Animals; Ascitic Fluid; Cell Transformation, Neoplastic; Drug Resistance; Drug Synergism; Female; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitosis; Thymidine; Time Factors; Vinblastine | 1975 |
Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.
Topics: Aminopterin; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Chick Embryo; DNA, Neoplasm; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Quinazolines; Sarcoma 180; Tetrahydrofolate Dehydrogenase; Time Factors | 1975 |
Sesquiterpene lactones XVII. Cytostatic and pharmacological activity.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dactinomycin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Sarcoma 180; Sesquiterpenes; Transplantation, Homologous | 1975 |
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Multiple folate transport systems in L1210 cells.
Topics: Animals; Biotin; Carrier Proteins; Chromatography, Affinity; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1992 |
Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Biological Transport; Cell Membrane; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tumor Cells, Cultured | 1992 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
DNA fragmentation, dATP pool elevation and potentiation of antifolate cytotoxicity in L1210 cells by hypoxanthine.
Topics: Animals; Deoxyadenine Nucleotides; DNA Damage; Drug Synergism; Folic Acid; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1992 |
Antileukemic effects of recombinant human tumor necrosis factor alpha (rh-TNF alpha) with cyclophosphamide or methotrexate on leukemia L1210 and leukemia P388 in mice.
Topics: Animals; Combined Modality Therapy; Cyclophosphamide; Drug Evaluation, Preclinical; Female; Humans; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Recombinant Proteins; Time Factors; Tumor Necrosis Factor-alpha | 1992 |
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
Topics: Animals; Carrier Proteins; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1991 |
Sacrosine- and prolinedithiocarbamate pretreatment increases the therapeutic efficacy of doxorubicin, methotrexate, teniposide, mitoxantrone or cyclohexylchloroethylnitrosourea in leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cysteine; Doxorubicin; Drug Synergism; Female; Leukemia L1210; Lomustine; Methotrexate; Mice; Mice, Inbred DBA; Mitoxantrone; Proline; Sarcosine; Teniposide; Thiocarbamates | 1990 |
Antifolates induce primary inhibition of the de novo purine pathway prior to 5-aminoimidazole-4-carboxamide ribotide transformylase in leukemia cells.
Topics: Acyltransferases; Animals; Azaserine; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purine Nucleotides; Purines; Pyrimidines; Tumor Cells, Cultured | 1991 |
Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cells.
Topics: Animals; Catalysis; Cytosol; Hydrogen-Ion Concentration; Immune Sera; Isoenzymes; Kinetics; Leukemia L1210; Methotrexate; Tetrahydrofolate Dehydrogenase | 1991 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Plant Extracts; Tea; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1991 |
Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
Topics: Animals; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Quinazolines; Quinazolinones; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 1991 |
The influence of recombinant human tumor necrosis factor-alpha, alone and in combination with cyclophosphamide or methotrexate, on leukemia L1210 and normal hematopoiesis in mice.
Topics: Animals; Blood Cell Count; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Interactions; Female; Hematopoiesis; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Tumor Necrosis Factor-alpha | 1991 |
Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells.
Topics: Animals; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1991 |
[Combination therapy of CPT-11, a camptothecin derivative, with various antitumor drugs against L 1210 leukemia].
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Cyclophosphamide; Female; Irinotecan; Leukemia L1210; Methotrexate; Mice; Mitomycin; Mitomycins; Thioinosine | 1991 |
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 1991 |
Isolation and characterization of an L1210 cell line retaining the sodium-dependent carrier cif as its sole nucleoside transport activity.
Topics: 2-Chloroadenosine; Affinity Labels; Animals; Carrier Proteins; Cell Division; Cell Membrane; Cell Survival; Cladribine; Deoxyadenosines; Kinetics; Leukemia L1210; Membrane Transport Proteins; Methotrexate; Mice; Mutation; Nucleosides; Sodium; Thioinosine; Thymidine; Tumor Cells, Cultured | 1990 |
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Probenecid; Sulfobromophthalein; Verapamil | 1991 |
Methotrexate cytotoxicity as related to irreversible S phase arrest in mouse L1210 leukemia cells.
Topics: Animals; Bromodeoxyuridine; DNA; Flow Cytometry; Interphase; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1990 |
Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Peptide Synthases; Phenotype | 1990 |
Occurrence and significance of diastereomers of methotrexate alpha-peptides.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chromatography, High Pressure Liquid; Hydrolysis; Indicators and Reagents; Kinetics; Leukemia L1210; Methotrexate; Mice; Stereoisomerism | 1990 |
Direct search methods in the optimisation of cancer chemotherapy regimens.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Evaluation; Female; Ifosfamide; Leucovorin; Leukemia L1210; Methotrexate; Mice; Time Factors | 1990 |
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin B; Folic Acid; Glucose; Leukemia L1210; Methotrexate; Mice; Probenecid; Substrate Specificity; Sulfobromophthalein; Temperature; Tumor Cells, Cultured; Uric Acid; Vincristine | 1990 |
Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Drug Resistance; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1990 |
Growth inhibition by homofolate in tumor cells utilizing a high-affinity folate binding protein as a means for folate internalization.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Division; Folic Acid; Growth Inhibitors; Kinetics; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1990 |
Immunologic heterogeneity of dihydrofolate reductase from methotrexate sensitive and resistant L1210 leukemia cells.
Topics: Animals; Cytosol; Drug Resistance; Epitopes; Kinetics; Leukemia L1210; Methotrexate; Mice; Radioimmunoassay; Tetrahydrofolate Dehydrogenase | 1985 |
Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Topics: Animals; Cell Survival; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimetrexate | 1986 |
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse.
Topics: Animals; Carboxypeptidases; gamma-Glutamyl Hydrolase; Intestine, Small; Kinetics; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Sarcoma 180; Substrate Specificity; Tissue Distribution | 1986 |
The efficacy of combined therapy with methotrexate and 5-fluorouracil from the view point of cellular PRPP level of L1210 cells and HeLa S3 cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Methotrexate; Mice; Pentosephosphates; Phosphoribosyl Pyrophosphate | 1985 |
Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
Topics: Animals; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Formates; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Tumor Cells, Cultured | 1989 |
Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells.
Topics: Animals; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1988 |
[Potentiated antitumor effect of methotrexate by dipyridamole].
Topics: Amphotericin B; Animals; Antineoplastic Agents; Biological Transport; Dipyridamole; Drug Synergism; Female; Leukemia L1210; Male; Methotrexate; Mice; Nucleosides; Sarcoma 180; Tumor Cells, Cultured | 1989 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Mediation of cellular anion detoxification in leukemic cells by unidirectional efflux pumps.
Topics: Animals; Anions; Biological Transport; Cholic Acids; Cyclic AMP; Drug Resistance; Folic Acid; Leukemia L1210; Methotrexate; Tumor Cells, Cultured; Uric Acid | 1989 |
The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis.
Topics: Acyltransferases; Animals; Cell Division; Cell Line; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Purines; Stereoisomerism; Structure-Activity Relationship; Tetrahydrofolates; Tumor Cells, Cultured | 1989 |
Synergy between 5,10-dideaza-5,6,7,8-tetrahydrofolic acid and methotrexate in mice bearing L1210 tumors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Lethal Dose 50; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Tetrahydrofolates | 1989 |
[Neuroleukemia in mice with leukemia L1210 treated with methotrexate].
Topics: Animals; Drug Evaluation, Preclinical; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Nervous System Neoplasms | 1989 |
Expression of a folate binding protein in L1210 cells grown in low folate medium.
Topics: Animals; Biological Transport; Carrier Proteins; Culture Media; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Tumor Cells, Cultured | 1989 |
Alpha-monoamides of methotrexate as potential prodrugs.
Topics: Animals; Biotransformation; Cell Survival; Chromatography, High Pressure Liquid; Female; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Prodrugs | 1989 |
Photoaffinity and immunological probes of methotrexate transport proteins in drug-sensitive and -resistant leukemia cells.
Topics: Affinity Labels; Animals; Carrier Proteins; Drug Resistance; Folate Receptors, GPI-Anchored; Iodine Radioisotopes; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Tumor Cells, Cultured | 1989 |
Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo.
Topics: Animals; DNA, Neoplasm; Female; Folic Acid; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1989 |
A comparison of dihydrofolate reductase activity in intact leukemia cells and squamous cell carcinoma.
Topics: Animals; Biological Transport; Carcinoma, Squamous Cell; Cell Count; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Oxidation-Reduction; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Growth, flow cytometric, and karyological characterization of L1210 cell sublines resistant to various Pt derivatives.
Topics: Animals; Antineoplastic Agents; Cell Division; Cisplatin; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Karyotyping; Leukemia L1210; Methotrexate; Mice; Organoplatinum Compounds; Structure-Activity Relationship | 1989 |
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Division; Drug Resistance; Intracellular Signaling Peptides and Proteins; Kinetics; Leukemia L1210; Membrane Proteins; Methotrexate; Mice; Mutation; Neoplasm Proteins; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Methotrexate efflux in L1210 cells. Kinetic and specificity properties of the efflux system sensitive to bromosulfophthalein and its possible identity with a system which mediates the efflux of 3',5'-cyclic AMP.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Buffers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclic AMP; Glucose; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Leukemia L1210; Methotrexate; Mice; Onium Compounds; Organophosphorus Compounds; Potassium; Sulfobromophthalein | 1987 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Membrane; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Gene Amplification; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phenotype; Quinazolines; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate | 1988 |
Identification of the bromosulfophthalein-sensitive efflux route for methotrexate as the site of action of vincristine in the vincristine-dependent enhancement of methotrexate uptake in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Cytoskeleton; Energy Metabolism; Leukemia L1210; Methotrexate; Onium Compounds; Organophosphorus Compounds; Sulfobromophthalein; Tumor Cells, Cultured; Vincristine | 1988 |
Characterization of in-vitro drug release and biological activity of methotrexate-bovine serum albumin conjugates.
Topics: Animals; Cell Division; Drug Carriers; Kinetics; Leukemia L1210; Methotrexate; Mice; Serum Albumin, Bovine; Tumor Cells, Cultured | 1987 |
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis.
Topics: Animals; Cell Division; Cell Line; DNA Replication; DNA, Neoplasm; gamma-Glutamyl Hydrolase; Glycine; Humans; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Purines; Ribonucleotides; Tetrahydrofolates; Tumor Cells, Cultured | 1989 |
Cell cycle effects of trimetrexate (CI-898).
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Cells, Cultured; Cricetinae; Demecolcine; Drug Evaluation, Preclinical; Female; Flow Cytometry; Injections, Intraperitoneal; Interphase; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ovary; Quinazolines; Trimetrexate | 1986 |
Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Deoxyuracil Nucleotides; Depression, Chemical; DNA Replication; Dopamine; Floxuridine; Humans; Hydroxyurea; Leukemia L1210; Melanoma, Experimental; Methotrexate; Neoplasm Proteins; Thymidylate Synthase | 1987 |
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Topics: Animals; Cytarabine; Daunorubicin; Deoxyuridine; DNA; Dopamine; Floxuridine; Hydroxyurea; Kinetics; Leukemia L1210; Methotrexate; Thymidylate Synthase | 1987 |
Transient inhibition of DNA synthesis by 5-fluorodeoxyuridine leads to overexpression of dihydrofolate reductase with increased frequency of methotrexate resistance.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Drug Resistance; Floxuridine; Gene Amplification; Gene Expression Regulation; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1988 |
Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.
Topics: Affinity Labels; Animals; Folic Acid; Leukemia L1210; Lysine; Methotrexate; Mice; Ornithine; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1986 |
Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells.
Topics: Animals; Biological Transport, Active; Cell Line; Depression, Chemical; Leukemia L1210; Methionine; Methotrexate; Mice; Serine | 1987 |
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Thymidylate Synthase; Tritium | 1985 |
Synthesis and biological properties of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Line; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Tetrahydrofolates | 1988 |
Analogs of tetrahydrofolate directed at folate-dependent purine biosynthetic enzymes. Characteristics of mediated entry and transport-related resistance in L1210 cells for 5,10-dideazatetrahydrofolate and two 10-alkyl derivatives.
Topics: Alkylation; Animals; Biological Transport; Cell Division; Cell Membrane; Drug Resistance; Leukemia L1210; Methotrexate; Structure-Activity Relationship; Tetrahydrofolates; Tumor Cells, Cultured | 1988 |
Characterization of the methotrexate transport pathway in murine L1210 leukemia cells: involvement of a membrane receptor and a cytosolic protein.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Membrane; Cytosol; Folate Receptors, GPI-Anchored; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1988 |
Photoaffinity analogues of methotrexate as folate antagonist binding probes.
Topics: Animals; Azides; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured; Ultraviolet Rays | 1988 |
Thymidylate synthetase and thymidine kinase activities and methotrexate cytotoxicity during growth of L1210 and Ehrlich ascites tumor.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cytosol; Leukemia L1210; Methotrexate; Mice; Thymidine Kinase; Thymidylate Synthase | 1988 |
Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.
Topics: Animals; Folic Acid; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1988 |
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Organophosphonates; Peptide Synthases; Structure-Activity Relationship; Sulfonic Acids | 1988 |
Flow cytometric analysis by bromodeoxyuridine/DNA assay of cell cycle perturbation of methotrexate-treated mouse L1210 leukemia cells.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; DNA Replication; Dose-Response Relationship, Drug; Flow Cytometry; Leukemia L1210; Methotrexate; Time Factors | 1988 |
Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture.
Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; Chromosomes; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Hypoxanthine; Hypoxanthines; Leukemia L1210; Methotrexate; RNA, Neoplasm | 1988 |
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Topics: Aminobutyrates; Aminopterin; Animals; Cell Division; Folic Acid Antagonists; Growth Inhibitors; Leukemia L1210; Liver; Methotrexate; Mice; Ornithine; Peptide Synthases; Structure-Activity Relationship | 1987 |
[Mechanisms of resistance of anticancer drugs and trials for overcoming their resistance].
Topics: Animals; Cytarabine; Drug Resistance; Extracellular Space; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice | 1986 |
Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: evidence of the nature of the effect, possible host mediation, and pharmacokinetic significance.
Topics: Affinity Labels; Animals; Biological Transport; Cycloheximide; Dose-Response Relationship, Drug; Folic Acid; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Succinimides | 1987 |
[The metabolism of high-molecular-weight substances in cells and the effect of anticancer drugs].
Topics: Animals; DNA Repair; DNA Replication; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Molecular Weight; RNA, Messenger; RNA, Ribosomal | 1987 |
Demonstration of a schedule-dependent therapeutic synergism utilizing the interacting drugs methotrexate and teniposide in L1210 leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Synergism; Leukemia L1210; Mathematics; Methotrexate; Mice; Mice, Inbred Strains; Models, Biological; Statistics as Topic; Teniposide | 1987 |
Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions.
Topics: Animals; Anions; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Stereoisomerism | 1987 |
Photoaffinity analogues of methotrexate as folate antagonist binding probes. 1. Photoaffinity labeling of murine L1210 dihydrofolate reductase and amino acid sequence of the binding region.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Cyanogen Bromide; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Models, Molecular; Peptide Fragments; Photochemistry; Protein Binding; Protein Conformation | 1987 |
Photoaffinity analogues of methotrexate as folate antagonist binding probes. 2. Transport studies, photoaffinity labeling, and identification of the membrane carrier protein for methotrexate from murine L1210 cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Carrier Proteins; Cell Membrane; Intracellular Signaling Peptides and Proteins; Kinetics; Leukemia L1210; Methotrexate; Mice; Molecular Weight; Neoplasm Proteins; Structure-Activity Relationship | 1987 |
Effects of methotrexate on the intracellular nucleotide pools and its role in combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Leukemia L1210; Methotrexate; Mice; Nucleotides | 1986 |
[Studies on the mechanisms of resistance to methotrexate--with special emphasis on the change of nucleotide pools].
Topics: Animals; Drug Resistance; Hybridization, Genetic; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nucleotides | 1986 |
Methotrexate analogues-27. Dual inhibition of dihydrofolate reductase and folylpolyglutamate synthetase by methotrexate and aminopterin analogues with a gamma-phosphonate group in the side chain.
Topics: Aminopterin; Animals; Cell Line; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Peptide Synthases; Structure-Activity Relationship | 1986 |
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil | 1986 |
The role of methionine in methotrexate-sensitive and methotrexate-resistant mouse leukemia L1210 cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cisplatin; Drug Resistance; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methionine; Methotrexate; Mice; Neoplasm Proteins; Sodium | 1987 |
L1210 dihydrofolate reductase: activation and enhancement of methotrexate sensitivity.
Topics: Animals; Dithionitrobenzoic Acid; Electrophoresis, Agar Gel; Enzyme Activation; Folic Acid Antagonists; Iodoacetamide; Isoenzymes; Leukemia L1210; Methotrexate; Mice; Potassium Chloride; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrathionic Acid | 1985 |
Polylysine-drug conjugates.
Topics: 6-Aminonicotinamide; Animals; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Division; Cell Survival; Daunorubicin; Doxorubicin; HeLa Cells; Humans; Indicators and Reagents; Kinetics; Leukemia L1210; Methods; Methotrexate; Mice; Naphthacenes; Polylysine; Structure-Activity Relationship | 1985 |
Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo.
Topics: Animals; Folic Acid; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation | 1985 |
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil.
Topics: Animals; Cell Survival; DNA Replication; Drug Interactions; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidylate Synthase; Transcription, Genetic | 1985 |
Characterization of the multiple transport routes for methotrexate in L1210 cells using phthalate as a model anion substrate.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Glucose; Kinetics; Leukemia L1210; Methotrexate; Mice; Oligomycins; Phosphates; Phthalic Acids; Radioisotope Dilution Technique; Sulfobromophthalein; Thiamine Pyrophosphate | 1985 |
Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.
Topics: Animals; Cell Division; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Lacticaseibacillus casei; Leukemia L1210; Mathematics; Methotrexate; Methyltransferases; Pteroylpolyglutamic Acids; Quinazolines; Thymidylate Synthase | 1985 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Mitomycin; Mitomycins; Nitrosourea Compounds; Thioguanine | 1985 |
Quantitative correlations of biological activities of dactinomycin analogs and methotrexate derivatives with van der Waals volume.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Dactinomycin; DNA; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Structure-Activity Relationship; Thymidylate Synthase | 1985 |
Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.
Topics: Animals; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Solubility; Structure-Activity Relationship; Triazines | 1986 |
Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.
Topics: Animals; Carcinoma, Krebs 2; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Mice, Inbred ICR; Tetrahydrofolates | 1986 |
Characterization of the individual transport routes that mediate the influx and efflux of methotrexate in CCRF-CEM human lymphoblastic cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cells, Cultured; Glucose; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Leukemia; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Oligomycins; Probenecid; Sulfobromophthalein; Tetrahydrofolates; Tritium | 1986 |
Transport of folate compounds in L1210 cells: kinetic evidence that folate influx proceeds via the high-affinity transport system for 5-methyltetrahydrofolate and methotrexate.
Topics: Animals; Biological Transport; Cells, Cultured; Chromatography, Thin Layer; Drug Contamination; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolates; Tritium | 1986 |
Regiospecific gamma-conjugation of methotrexate to poly(L-lysine). Chemical and biological studies.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Folic Acid Antagonists; Kinetics; Leukemia L1210; Liver Neoplasms, Experimental; Methotrexate; Mice; Molecular Weight; Peptides; Polylysine; Protein Binding; Rats; Structure-Activity Relationship | 1985 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
[Biochemical modulation in cancer chemotherapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Synergism; Fluorouracil; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nucleosides; Pyrimidine Nucleosides | 1985 |
Inhibitory effects of probenecid on the individual transport routes which mediate the influx and efflux of methotrexate in L1210 cells.
Topics: Animals; Biological Transport; Cells, Cultured; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Probenecid; Sulfates | 1985 |
Inhibition of dihydrofolate reductase, methotrexate transport, and growth of methotrexate-sensitive and -resistant L1210 leukemia cells in vitro by 5-substituted 2,4-diaminoquinazolines.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Structure-Activity Relationship | 1985 |
Inhibition of cell proliferation and dihydrofolate reductase by liposomes containing methotrexate-dimyristoylphosphatidylethanolamine derivatives and by the glycerophosphorylethanolamine analogs.
Topics: Ammonium Chloride; Animals; Biological Transport; Cell Division; Chemical Phenomena; Chemistry; Deoxyuridine; DNA; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liposomes; Methotrexate; Mice; Phosphatidylethanolamines; Thiamine Pyrophosphate | 1985 |
[The effect of methotrexate on intracellular nucleotide pools].
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Drug Synergism; Guanosine Triphosphate; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Nucleotides; Purine Nucleotides; Pyrimidine Nucleotides | 1985 |
A low density lipoprotein-methotrexate covalent complex and its activity against L1210 cells in vitro.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia L1210; Lipoproteins, LDL; Methotrexate; Mice | 1985 |
Enhanced production of intracellular ara-CTP after sequential use of methotrexate and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytosine Nucleotides; Drug Administration Schedule; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains | 1985 |
Polymorphism of dihydrofolate reductase from a methotrexate-resistant subline of L1210 cells.
Topics: Animals; Cell Line; Dithionitrobenzoic Acid; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Isoelectric Focusing; Isoenzymes; Leukemia L1210; Macromolecular Substances; Methotrexate; Mice; Protein Conformation; Tetrahydrofolate Dehydrogenase | 1985 |
Timing- and sequence-dependent synergism between etoposide and methotrexate or etoposide, methotrexate and 5-fluorouracil in advanced leukemia L1210.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Female; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Podophyllotoxin; Time Factors | 1985 |
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosphamide; Cytarabine; Drug Synergism; Emetine; Fluorouracil; Ketones; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperazines; Platinum; Propane; Time Factors | 1973 |
The effects of antibiotics and cancer chemotherapeutic agents on the cellular transport and antitumor activity of methotrexate in L1210 murine leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Biological Transport; Bleomycin; Cells, Cultured; Cephalothin; Dose-Response Relationship, Drug; Drug Synergism; Female; Glucocorticoids; Hydroxyurea; Kanamycin; Leukemia L1210; Methotrexate; Mice; Penicillins; Vinblastine; Vinca Alkaloids; Vincristine | 1973 |
Antibodies as carriers of anticancer agents.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents; Boron; Carcinoma, Ehrlich Tumor; Chlorambucil; Cricetinae; Cytotoxicity Tests, Immunologic; Diphtheria Toxin; Glucose Oxidase; Immune Sera; Immunotherapy; Iodine Radioisotopes; Leukemia L1210; Lymphoma; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Rabbits | 1974 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |
Turnover of dihydrofolate reductase in rapidly dividing cells.
Topics: Animals; Carbon Isotopes; Cell Division; Cells; Chromatography, Affinity; Drug Resistance, Microbial; Half-Life; Isotope Labeling; Kinetics; Lacticaseibacillus casei; Leucine; Leukemia L1210; Methotrexate; Mice; NADP; Polysaccharides; Tetrahydrofolate Dehydrogenase; Time Factors | 1973 |
Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.
Topics: Animals; Chlorine; Enterococcus faecalis; Esters; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1973 |
Pharmacodynamic and pharmacokinetic measurements of antitumor agents.
Topics: Animals; Antineoplastic Agents; Body Surface Area; Cell Division; Cricetinae; Culture Techniques; Cyclophosphamide; Cytarabine; Dogs; Half-Life; Haplorhini; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice; Mice, Inbred Strains; Neoplasms; Rats; Species Specificity; Time Factors | 1974 |
Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
Topics: Animals; Antimalarials; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Liver; Malaria; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Plasmodium berghei; Pteridines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Methotrexate analogs. 4.7-Methyl derivatives of methotrexate and dichloromethotrexate. A new synthesis and some biological studies.
Topics: Animals; Cell Line; Chlorine; Enterococcus faecalis; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Methane; Methotrexate; Mice; Spectrophotometry, Ultraviolet | 1974 |
Interaction of drugs inhibiting different steps in the synthesis of DNA.
Topics: Animals; Cells, Cultured; Cytarabine; Depression, Chemical; DNA, Neoplasm; Drug Antagonism; Drug Interactions; Drug Synergism; Feedback; Floxuridine; In Vitro Techniques; Isoquinolines; Leukemia L1210; Methotrexate; Mice; Models, Biological; Thiosemicarbazones | 1972 |
Studies with a mathematical model of folate metabolism.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Folic Acid; Formates; Glycine; Hydrolases; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Models, Biological; Oxidoreductases; Pentosephosphates; Purines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Transferases | 1973 |
Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro.
Topics: Animals; Biodegradation, Environmental; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chromatography, Gel; Cycloheximide; Drug Stability; Electrophoresis; Enzyme Activation; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Liver Neoplasms; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triamterene; Trimethoprim | 1971 |
Dihydrofolate reductase from the L1210R murine lymphoma. Fluorometric measurements of the interaction of the enzyme with coenzymes, substrates, and inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Enzymes; Fluorometry; Folic Acid; Leukemia L1210; Lymphoma; Methotrexate; Mice; NADP; Triamterene | 1966 |
Dihydrofolate reductase from the L1210 R murine lymphoma. Further studies on the binding of substrates and inhibitors to the enzyme.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Fluorometry; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; NADP; Protein Binding; Pyrimidines; Tetrahydrofolate Dehydrogenase; Triamterene | 1967 |
"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography; Enzyme Activation; Enzyme Induction; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Immune Sera; Leukemia L1210; Leukocytes; Methotrexate; Molecular Weight; NAD; NADP; Neoplasms; Protein Denaturation; Tetrahydrofolate Dehydrogenase | 1970 |
Purification of tetrahydrofolate dehydrogenase by affinity chromatography.
Topics: Alkylation; Ammonium Sulfate; Animals; Buffers; Cell Line; Chemical Precipitation; Chromatography, Affinity; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methods; Methotrexate; NADP; Osmolar Concentration; Polysaccharides; Protein Binding; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.
Topics: Animals; Antigen-Antibody Reactions; Cell Line; Chromatography; Chromatography, Gel; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Guanidines; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred Strains; NADP; Potassium Chloride; Protein Denaturation; Pyrimidines; Spleen; Tetrahydrofolate Dehydrogenase; Triazines; Urea | 1971 |
Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.
Topics: Aminopterin; Animals; Antineoplastic Agents; Ascitic Fluid; Aspartic Acid; Benzoates; Binding, Competitive; Biological Transport, Active; Cell Line; Cells, Cultured; Diffusion; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Streptococcus pneumoniae; Temperature; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium | 1972 |
The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Dose-Response Relationship, Drug; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors; Tritium; Uridine | 1974 |
[Possibility of utilizing lymphatic leukemia L1210 as a first screening model in the primary selection of new antitumor antibiotics].
Topics: Administration, Oral; Aminoglycosides; Animals; Antibiotics, Antineoplastic; Dactinomycin; Daunorubicin; Drug Evaluation, Preclinical; Hybridization, Genetic; Injections, Intravenous; Injections, Subcutaneous; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naphthacenes; Neoplasm Transplantation; Olivomycins; Streptonigrin; Time Factors | 1974 |
Dose-related synergism of cytosine arabinoside and methotrexate against murine leukemia L1210.
Topics: Animals; Cytarabine; Dose-Response Relationship, Drug; Drug Synergism; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1974 |
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Kinetics; Leukemia L1210; Lomustine; Mathematics; Methotrexate; Mice; Mitomycins; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors; Vincristine | 1974 |
Effects of sulfhydryl inhibitors upon transport of folate compounds into L1210 cells.
Topics: Animals; Benzenesulfonates; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Iodoacetates; Kinetics; Leukemia L1210; Mercury; Methotrexate; Mice; Organometallic Compounds; Sulfhydryl Reagents; Tetrahydrofolates; Time Factors | 1974 |
Further evaluation of the antitumor activity of homofolate and its reduced derivatives against methotrexate-insensitive tumors.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Carcinoma 256, Walker; Cell Line; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1972 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, Animal; Drug Therapy, Combination; Ethylenediamines; Fluorenes; Fluorouracil; Interferon Inducers; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Prednisolone; Thioxanthenes; Vincristine | 1974 |
7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.
Topics: Animals; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mice; Oxidation-Reduction; Polycythemia Vera; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil.
Topics: Animals; Cell Line; Cells, Cultured; Drug Antagonism; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Purines; Spectrophotometry; Tritium; Uracil Nucleotides | 1973 |
Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
Topics: Animals; Biological Assay; Cell Count; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxyribonucleotides; Dose-Response Relationship, Drug; Folic Acid; Humans; L Cells; Leukemia L1210; Lymphoma; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Thymidine; Thymidylate Synthase | 1974 |
Pharmacology of 3,5-diamino-1,24-triazole (guanazole). 1. Antitumor activity of guanazole.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cyclophosphamide; Cytarabine; Depression, Chemical; Female; Hydroxyurea; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Lymphoma, Large B-Cell, Diffuse; Male; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Plasmacytoma; Structure-Activity Relationship; Triazoles | 1972 |
Folate antagonists covalently linked to carbohydrates: synthesis, properties, and use in the purification of dihydrofolate reductases.
Topics: Aminopterin; Animals; Cell Line; Cellulose; Chemical Phenomena; Chemistry; Chickens; Chromatography, Affinity; Chromatography, Gel; Dextrans; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Leukemia L1210; Liver; Methotrexate; Mice; Molecular Weight; Polysaccharides; Protein Binding; Spectrophotometry; Starch; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1972 |
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. X.
Topics: Alkylating Agents; Amides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Imidazoles; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Nitrosourea Compounds; Purines; Pyrimidines; Time Factors; Urea | 1972 |
[Antineoplastic activity of antibiotic 1719 from the group of diazo compounds].
Topics: Administration, Oral; Animals; Antibiotics, Antineoplastic; Azo Compounds; Carcinoma, Ehrlich Tumor; Female; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Leukemia L1210; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sarcoma 180; Sarcoma 37; Stomach Neoplasms; Time Factors; Vaginal Neoplasms | 1972 |
Chemotherapeutic effects of compound 593A (NSC-135758) on mouse leukemias and some transplanted animal tumors.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Ascites; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Piperazines; Piperidines; Transplantation, Homologous | 1973 |
Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.
Topics: Animals; Cell Membrane Permeability; Deoxyuridine; DNA, Neoplasm; Injections, Intraperitoneal; Injections, Subcutaneous; Intestine, Small; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Peritoneum; Tetrahydrofolate Dehydrogenase; Transplantation, Homologous; Tritium | 1973 |
Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues.
Topics: Animals; Ascites; Ascitic Fluid; Bone Marrow; Deoxyuridine; Depression, Chemical; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Duodenum; Intestinal Mucosa; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine Nucleotides; Tritium | 1973 |
Recent advances in the biochemical pharmacology of folic acid antagonists.
Topics: Aldehyde Oxidoreductases; Aminopterin; Animals; Esters; Folic Acid Antagonists; Hydrogen-Ion Concentration; Immune Tolerance; Immunosuppressive Agents; Leukemia L1210; Liver; Male; Methotrexate; Mice; Rabbits; Spectrophotometry | 1973 |
Characteristics of the vincristine-induced augmentation of methotrexate uptake in Ehrlich ascites tumor cells.
Topics: Animals; Azides; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Division; Cells, Cultured; Chlorides; DNA; Dose-Response Relationship, Drug; Drug Synergism; Glucose; Kinetics; L Cells; Leukemia L1210; Membrane Potentials; Methotrexate; Mice; Tritium; Vincristine; Water | 1973 |
Antineoplastic activity of lipid-soluble dialkyl esters of methotrexate.
Topics: Animals; Esters; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice | 1973 |
Effect of combination treatment with adriamycin and methotrexate on the survival time of leukemic (L 1210) mice.
Topics: Animals; Doxorubicin; Drug Therapy, Combination; Hybridization, Genetic; Injections, Intraperitoneal; Leukemia L1210; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Time Factors | 1973 |
The basis for the disparate sensitivity of L1210 leukemia and Walker 256 carcinoma to a new triazine folate antagonist.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carcinoma 256, Walker; Deoxyuridine; DNA, Neoplasm; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triazines; Tritium | 1973 |
Analysis of tests of chemotherapeutic agents involving repeated drug treatment.
Topics: Animals; Antineoplastic Agents; Carmustine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia L1210; Methotrexate; Mice; Models, Biological; Time Factors | 1973 |
The effects of antineoplastic agents on the respiratory activity of murine lymphocytic leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chlorambucil; Dactinomycin; Dose-Response Relationship, Drug; Leukemia L1210; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Oxygen Consumption; Prednisone; Vinblastine | 1973 |
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid.
Topics: Animals; Chlorine; Folic Acid Antagonists; Glutamates; Humans; Leukemia; Leukemia L1210; Methotrexate; Mice; Pteridines | 1974 |
Antigenic changes associated with resistance to methotrexate and 6-mercaptopurine in L1210 ascites lymphoma.
Topics: Animals; Antigens, Neoplasm; Drug Resistance; Immunization; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycins; Neoplasm Transplantation; Transplantation, Homologous | 1974 |
Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.
Topics: Animals; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tritium | 1974 |
Potential anticancer agents. 10. Synthesis of N-(4((2,4-diamino-7-pteridyl)methyl)-N10-methylamino)benzoyl)glutamic acid.
Topics: Animals; Isomerism; Lethal Dose 50; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Mice, Inbred Strains; Rats; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1974 |
Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells.
Topics: Aminopterin; Animals; Biological Transport, Active; Cells, Cultured; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Pyrimidines; Quinazolines | 1974 |
Studies with tetrahydrohomofolate and thymidylate synthetase from amethopterin-resistant mouse leukemia cells.
Topics: Animals; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Deoxyuridine; Drug Stability; Escherichia coli; Folic Acid; Leukemia L1210; Ligases; Methotrexate; Mice; Nucleotides; Spleen; Splenic Neoplasms; Tetrahydrofolate Dehydrogenase | 1968 |
The metabolic fate of tritiated methotrexate. I. Absorption, excretion, and distribution in mice, rats, dogs and monkeys.
Topics: Animals; Dogs; Feces; Haplorhini; In Vitro Techniques; Intestinal Absorption; Leukemia L1210; Liver; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Tritium; Urine | 1965 |
Pharmacologic aspects of homofolate derivatives in relation to amethopterin-resistant murine leukemia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Enterococcus faecalis; Folic Acid; Leukemia L1210; Ligases; Male; Methotrexate; Mice; Nucleotides; Tetrahydrofolate Dehydrogenase | 1966 |
Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification and properties.
Topics: Animals; Chemical Phenomena; Chemical Precipitation; Chemistry, Physical; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Fluorometry; Hydroxyapatites; Immunodiffusion; Leukemia L1210; Methotrexate; Mice; Peritoneal Neoplasms; Protein Denaturation; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolate Dehydrogenase | 1967 |
Deaza aalogues of amethopterin (methotrexate).
Topics: Animals; Antineoplastic Agents; Binding Sites; Carcinoma; Cell Line; Columbidae; Enterococcus faecalis; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; Laryngeal Neoplasms; Leukemia L1210; Liver; Methotrexate; Protein Binding; Structure-Activity Relationship | 1971 |
Discussion paper: amethopterin linked covalently to water-soluble macromolecules.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Gel; Lacticaseibacillus casei; Leukemia L1210; Macromolecular Substances; Methotrexate; Mice; Polymers; Protein Binding; Serum Albumin; Solubility; Spectrum Analysis; Structure-Activity Relationship; Time Factors; Ultracentrifugation; Ultraviolet Rays; Water | 1971 |
In vivo effects of methotrexate. Inhibition of DNA synthesis and cell death in sensitive and resistant L1210 ascites populations.
Topics: Animals; Cell Count; Cell Survival; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA Replication; DNA, Neoplasm; Drug Resistance; Female; Injections, Intraperitoneal; Iodine Isotopes; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1972 |
Evaluation of anti-tumor agents on tRNA methylase activity of leukemia L1210.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Carmustine; Cell Count; Cells, Cultured; Depression, Chemical; In Vitro Techniques; Leucine; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Neoplasm Proteins; Poly I-C; RNA, Transfer; Vincristine | 1972 |
Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y.
Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Cyclophosphamide; Cytarabine; Cytogenetics; Drug Resistance; Female; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Transplantation, Heterologous; Transplantation, Homologous | 1972 |
Cell proliferation and the differential response of normal and malignant tissues. Silvanus Thompson Memorial Lecture.
Topics: Animals; Blood Vessels; Busulfan; Cell Survival; Cyclophosphamide; Cytarabine; Diffusion; Epithelial Cells; Epithelium; Fibrosarcoma; Hematopoietic Stem Cells; Intestine, Small; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Effects; Rats | 1972 |
Improved purification of tetrahydrofolate dehydrogenase from L1210 leukemia by affinity chromatography.
Topics: Animals; Cell Line; Chromatography, Affinity; Drug Resistance; Electrophoresis, Disc; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Male; Methods; Methotrexate; Mice; Mutation; Nucleotides; Polysaccharides; Protein Binding; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells.
Topics: Animals; Carbon Isotopes; Chloromercuribenzoates; Chromatography, Gel; Coenzymes; Depression, Chemical; Fluorides; Folic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Leukemia L1210; Methotrexate; Mice; Ouabain; Tetrahydrofolates; Tritium | 1972 |
Increased lifespan using the priming dose schedule design in carbazilquinone (NSC-134679) treatment of mouse leukemia L1210.
Topics: Animals; Antineoplastic Agents; Azirines; Carbamates; Cyclophosphamide; Injections, Intraperitoneal; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Quinones; Time Factors | 1972 |
Effect of day of dosage omission on survival time in the regularly scheduled methotrexate (NSC-740) treatment of leukemia L1210.
Topics: Animals; Injections, Intraperitoneal; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Statistics as Topic; Time Factors | 1972 |
The mechanism of folate transport in rabbit reticulocytes.
Topics: Animals; Azides; Biological Transport, Active; Erythrocytes; Folic Acid; Iodoacetates; Kinetics; Leukemia L1210; Methotrexate; Rabbits; Reticulocytes; Tetrahydrofolates | 1972 |
Synthesis and biologic evaluation of 7-hydroxymethotrexate, 7-methylaminopterin, and 7-methylmethotrexate.
Topics: Animals; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Methylamines; Mice; Pterins; Rats | 1972 |
Lack of intracellular conversion of dihydrohomofolate to tetrahydrohomofolate in leukemia cells with high levels of dihydrofolate reductase.
Topics: Animals; Cells, Cultured; Chromatography, DEAE-Cellulose; Folic Acid; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Oxidation-Reduction; Spectrum Analysis; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1972 |
The effect of the sequence of administration of cytoxan and methotrexate on the life-span of L1210 leukemic mice.
Topics: Animals; Cyclophosphamide; Leukemia L1210; Longevity; Male; Methotrexate; Mice; Mice, Inbred Strains | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cyclophosphamide; Cytarabine; Cytidine; Dose-Response Relationship, Drug; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Sarcoma 180 | 1972 |
The return of antimetabolite sensitivity in methotrexate- and 6-mercaptopurine-resistant L1210 murine leukemia by the process of adaptive selection.
Topics: Animals; Cell Line; Cells, Cultured; Crosses, Genetic; Drug Resistance; Female; Folic Acid; Genetic Variation; Hypoxanthines; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Pentosyltransferases; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Transplantation, Homologous | 1972 |
Effect of different doses of methotrexate (NSC-740), cytosine arabinoside (NSC-63878), and cyclophosphamide (NSC-26271) on drug resistance in mice with L1210 leukemia.
Topics: Animals; Cyclophosphamide; Cytarabine; Drug Resistance; Female; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation | 1972 |
Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Cytarabine; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Spleen | 1972 |
Reversal of resistance to methotrexate in L1210 murine leukemia by uracil.
Topics: Animals; DNA; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate; Nucleic Acids; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium; Uracil | 1971 |
Effects of priming dose schedules in methotrexate treatment of mouse leukemia L1210.
Topics: Animals; Leukemia L1210; Male; Methotrexate; Mice | 1971 |
A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.
Topics: Animals; Binding Sites; Biological Transport; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, DEAE-Cellulose; Diffusion; Folic Acid; Folic Acid Antagonists; Formates; Kinetics; Leukemia L1210; Methotrexate; Methylation; Mice; Models, Biological; Tritium | 1971 |
Effect of pretreatment with methotrexate on the reduction of dihydrohomofolic acid in mice.
Topics: Animals; Chromatography, DEAE-Cellulose; Folic Acid; Kidney; Leukemia L1210; Liver; Male; Methotrexate; Mice; Spleen; Stereoisomerism; Tetrahydrofolate Dehydrogenase | 1971 |
Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance.
Topics: Animals; Cell Line; Drug Resistance; Leukemia L1210; Male; Methotrexate; Mice; Spleen; Tetrahydrofolate Dehydrogenase | 1971 |
Sequential biochemical alteration to antifolate resistance in L1210 leukaemia.
Topics: Animals; Biological Transport, Active; Cell Division; Cytogenetics; Drug Hypersensitivity; Fluorouracil; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Molecular Biology; Neoplasm Transplantation; Tetrahydrofolate Dehydrogenase; Tritium | 1967 |
The use of long-term human leukocyte cell cultures as models for the study of antileukemic agents.
Topics: Animals; Antineoplastic Agents; Burkitt Lymphoma; Culture Techniques; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Mercaptopurine; Methotrexate; Mice; Prednisolone; Vincristine | 1969 |
The treatment of acute lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Asparaginase; Blood Platelets; Bone Marrow Cells; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Synergism; Hemorrhage; Humans; Infections; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Mice; Prednisone; Prognosis; Thrombocytopenia; Vincristine | 1970 |
Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.
Topics: Adult; Aged; Animals; Biological Transport; Cell Line; Chemical Precipitation; Chromatography; Chromatography, Gel; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid Antagonists; Humans; Hydroxyapatites; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Mice; Quaternary Ammonium Compounds; Quinazolines; Spectrophotometry; Sulfates; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1970 |
Some biochemical and pharmacologic properties of amethopterin-albumin.
Topics: Albuminuria; Animals; Folic Acid Antagonists; Leukemia L1210; Macromolecular Substances; Methotrexate; Mice; Protein Binding; Serum Albumin | 1971 |
Sites of action of amethopterin: intrinsic and acquired drug resistance.
Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; DNA, Neoplasm; Drug Resistance; Female; Folic Acid; Kinetics; Leukemia L1210; Lymphoma; Methotrexate; Protein Binding; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium; Uridine | 1971 |
Growth rate and cell kill.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Humans; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium; Uridine | 1971 |
The characteristics of the membrane transport of amethopterin and the naturally occurring folates.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspirin; Azides; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Cells, Cultured; Chlorides; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Nitrates; Organophosphorus Compounds; Phosphates; Rabbits; Sulfates; Time Factors | 1971 |
Studies with a 2,4-diamino-5-chloro-quinazoline antifolate: in vitro and invivo correlates in normal and lymphosarcoma dogs.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; DNA, Neoplasm; Dogs; Folic Acid Antagonists; Hydrogen-Ion Concentration; Injections, Intravenous; Leukemia L1210; Lymphoma, Non-Hodgkin; Methotrexate; Quinazolines; Thymine Nucleotides; Time Factors; Tritium | 1971 |
Prospects for improved folate antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Stability; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Prospective Studies; Structure-Activity Relationship | 1971 |
Dihydrofolate reductase activity and loss of resistance in an antifolate-resistant subline of leukemia L1210 after discontinuation of treatment.
Topics: Animals; Cell Line; Drug Resistance; Leukemia L1210; Male; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1970 |
Active immunotherapy in the treatment of experimental leukemias and acute lymphoblastic leukemia in man.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Animals; BCG Vaccine; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Transfusion; Mercaptopurine; Methotrexate; Mice; Middle Aged; Neoplasm Transplantation; Prednisone; Radiation Effects; Transplantation, Homologous; Vincristine | 1970 |
Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.
Topics: Animals; Biological Transport, Active; Cell Membrane Permeability; Culture Techniques; Depression, Chemical; Folic Acid; Folic Acid Antagonists; Kinetics; Leucovorin; Leukemia L1210; Membrane Potentials; Methotrexate; Mice; Temperature; Tetrahydrofolate Dehydrogenase | 1968 |
[Chemotherapy of L1210 leukemia: comparison of 7 drugs given either continuously for 20 days, or in a single massive dose, early or late].
Topics: Animals; Cyclophosphamide; Daunorubicin; Leucovorin; Leukemia L1210; Life Expectancy; Mercaptopurine; Methotrexate; Methylprednisolone; Mice; Statistics as Topic; Vinblastine; Vincristine | 1968 |
The use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate.
Topics: Administration, Oral; Animals; Gastrointestinal Diseases; Intestinal Diseases; Jejunum; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice | 1970 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Adoptive immunotherapy of acute leukemia: experimental and clinical results.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Humans; In Vitro Techniques; Leukemia; Leukemia L1210; Methotrexate; Mice; Mortality; Radiation Injuries; Radiation Injuries, Experimental; Transplantation, Homologous | 1965 |
Tumor cell death in vivo after administration of chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Iodine Isotopes; Leukemia L1210; Methotrexate; Mice | 1969 |
Characteristics of folic acid transport in the L1210 leukemia cell.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Culture Techniques; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Nitrogen; Oxygen; Time Factors; Tritium | 1969 |
A comparison of 4-amino-4-deoxy-N10-methylpteroic acid and methotrexate transport by mouse leukemia cells.
Topics: Animals; Biological Transport; Cell Line; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Methotrexate; Nitrogen; Time Factors; Tritium | 1969 |
The time factor in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Leukemia L1210; Methotrexate; Mice; Time Factors; Vincristine | 1970 |
Distribution studies of tetrahydrohomofolic acid (NSC 89473) in mice.
Topics: Animals; Bile; Brain Chemistry; Chromatography; Erythrocytes; Folic Acid; Intestines; Kidney; Leukemia L1210; Liver; Lung; Methotrexate; Mice; Muscles; Myocardium; Spectrophotometry; Spleen | 1970 |
Amethopterin-induced changes in the multiple forms of dihydrofolate reductase from L1210 cells.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Line; Cell-Free System; Depression, Chemical; Electrophoresis; Female; Folic Acid Antagonists; Leukemia L1210; Metabolism; Methotrexate; Mice; Neoplasm Transplantation; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase; Tetrazolium Salts; Time Factors | 1970 |
Chemotherapeutic effect of a water-oil-water emulsion of methotrexate on the mouse L1210 leukaemia.
Topics: Animals; Emulsions; Leukemia L1210; Methotrexate; Mice | 1970 |
[Preliminary studies of the evaluation of immunodepressive activity in L1210 leukemia allografts in mice].
Topics: Amides; Animals; Azathioprine; Azo Compounds; Busulfan; Cyclophosphamide; Glycine; Immunosuppressive Agents; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Transplantation, Homologous | 1970 |
Effects of perfusion with amethopterin on L1210 leukemia cells in spin filter culture.
Topics: Agar; Animals; Binding Sites; Cell Count; Cell Division; Centrifugation; Clone Cells; Culture Techniques; Deoxyuridine; DNA, Neoplasm; Leukemia L1210; Methods; Methotrexate; Methylation; Mice; Perfusion; Tetrahydrofolate Dehydrogenase; Time Factors; Transferases; Tritium; Uracil Nucleotides | 1970 |
Folic acid analogs. II. p-[(2,6-Diamino-8-purinyl)methyl]amino-benzoyl-L-glutamic acid and related compounds.
Topics: Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Glutamates; Leukemia L1210; Methotrexate; Purines; Pyrimidines | 1970 |
Effect of carbazilquinone on lymphoid leukemia L-1210.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Azirines; Cyclophosphamide; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Male; Methotrexate; Mice; Mitomycins; Quinones; Time Factors; Triaziquone | 1970 |
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Half-Life; Hydroxyurea; In Vitro Techniques; Kinetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitrosourea Compounds; Thiosemicarbazones | 1970 |
Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane Permeability; Chromatography, DEAE-Cellulose; Ethanol; Flavins; Folic Acid; Kinetics; Leukemia L1210; Light; Methotrexate; Mice; Photochemistry; Protein Binding; Radiation Effects; Riboflavin; Spectrophotometry; Temperature; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1970 |
Variation of dihydrofolate reductase activity during in vitro and in vivo growth of sublines of L1210 lymphoma.
Topics: Animals; Cell Line; Chromosomes; Clone Cells; Culture Techniques; Electrophoresis; Karyotyping; Leukemia L1210; Lymphoma; Methods; Methotrexate; Mice; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase; Time Factors | 1971 |
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. IX.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Leukemia L1210; Mercaptopurine; Methotrexate; Mice | 1971 |
On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.
Topics: Animals; Biological Transport, Active; Chromosome Aberrations; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Temperature; Tritium | 1968 |
Evaluation of combination chemotherapy with three drugs.
Topics: Animals; Cyclophosphamide; Drug Synergism; Leukemia L1210; Methotrexate; Mice | 1968 |
On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.
Topics: Animals; Deoxyuridine; DNA, Neoplasm; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Transplantation; Nucleosides; Nucleotides; Thymidine | 1968 |
Immunosuppressive activity of methotrexate and arabinosyl cytosine in mice bearing L1210 leukaemia.
Topics: Animals; Cytarabine; Histocompatibility; Leukemia L1210; Methotrexate; Mice | 1968 |
Quinazoline antifolates: biologic activities.
Topics: Animals; Cell Line; Culture Techniques; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Streptococcus | 1968 |
Spontaneous and amethopterin-induced death of L1210 leukaemia cells in vivo.
Topics: Animals; DNA, Neoplasm; Idoxuridine; Injections, Intramuscular; Injections, Intraperitoneal; Iodine Radioisotopes; Leukemia L1210; Methotrexate; Mice | 1969 |
Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.
Topics: Animals; Azides; Binding Sites; Biological Transport, Active; Diffusion; Electrophysiology; In Vitro Techniques; Kinetics; Leukemia L1210; Methotrexate; Mice; Nitrogen; Pyruvates; Tritium | 1969 |
1,3-bis(2-chloroethyl)-1-nitrosourea (NSC-409962) and methotrexate (NSC-740) as combination therapy for advanced mouse leukemia L1210.
Topics: Animals; Female; Leukemia L1210; Male; Methotrexate; Mice; Nitroso Compounds; Urea | 1965 |
The effects of chemotherapy on the kinetics of leukemic cell behavior.
Topics: Animals; Cyclophosphamide; Kinetics; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Nitroso Compounds | 1965 |
Pathology of leukemia in the brain and meninges: postmortem studies of patients with acute leukemia and of mice given inoculations of L1210 leukemia.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents; Brain; Cerebrospinal Fluid; Child; Child, Preschool; Choroid Plexus; Female; Humans; In Vitro Techniques; Infant; Leukemia; Leukemia L1210; Male; Meninges; Methotrexate; Mice; Middle Aged; Nitroso Compounds; Pineal Gland; Pituitary Gland | 1965 |
Evaluation of antileukemic agents employing advanced leukemia L1210 in mice. VII.
Topics: Anilides; Animals; Antineoplastic Agents; Evaluation Studies as Topic; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Methotrexate; Mice | 1964 |
Chemotherapeutic effects on mammalian tumor cells. 3. Modification of leukemia L1210 growth kinetics with an antimetabolite.
Topics: Animals; Female; Leukemia L1210; Male; Methotrexate; Mice | 1966 |
Amethopterin resistance in clonal lines of L1210 mouse leukemia: some associated biologic and biochemical alterations.
Topics: Animals; Chromosomes; Folic Acid; Leukemia L1210; Methotrexate; Mice; Oxidoreductases | 1966 |
Effect of alkylating agents on meningeal leukemia L1210 arising in methotrexate-treated mice.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Cyclophosphamide; Leukemia L1210; Meninges; Methotrexate; Mice; Neoplasm Metastasis; Nitroso Compounds | 1966 |
Growth of L1210 mouse leukemia cells in vitro.
Topics: Animals; Chromosomes; Culture Techniques; Fluorouracil; Folic Acid; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Microscopy | 1966 |
Experimental evaluation of potential anticancer agents XV. On the relative rates of growth and host kill of "single" leukemia cells that survive in vivo cytoxan therapy.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Cell Division; Cyclophosphamide; Guanine; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mortality | 1966 |
The antileukemic effectiveness of 5-fluorouracil and methotrexate in the combination chemotherapy of advanced leukemia L1210 in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Methotrexate; Mice | 1966 |
Fate of amethopterin-resistant mutants in L1210 mouse leukemia populations.
Topics: Animals; Drug Hypersensitivity; Fluorouracil; In Vitro Techniques; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1966 |
Chemotherapy of leukemia L1210 in mice with 1-beta-d-arabinofuranosylcytosine hydrochloride. I. Influence of treatment schedules.
Topics: Animals; Antineoplastic Agents; Cytarabine; Leukemia L1210; Methotrexate; Mice | 1966 |