methotrexate has been researched along with Leukemia, Lymphocytic in 1150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1118 (97.22) | 18.7374 |
| 1990's | 14 (1.22) | 18.2507 |
| 2000's | 15 (1.30) | 29.6817 |
| 2010's | 2 (0.17) | 24.3611 |
| 2020's | 1 (0.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chaykovsky, M; Gaumont, Y; Gittelman, MC; Kisliuk, RL; Martinelli, JE | 1 |
| Chaykovsky, M; Gaumont, Y; Kisliuk, RL; Martinelli, JE | 1 |
| Rosowsky, A; Yu, CS | 1 |
| Ensminger, WD; Lazarus, H; Rosowsky, A; Yu, CS | 1 |
| Barredo, J; Grindey, GB; Jannatipour, M; Kuhnt, D; Moran, RG; Rinzel, SM; Shih, C; Taylor, EC | 1 |
| Forsch, RA; Freisheim, JH; Moran, RG; Reich, VE; Rosowsky, A | 1 |
| Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A | 1 |
| Bader, H; Cucchi, CA; Freisheim, JH; Radike-Smith, M; Rosowsky, A; Wick, MM | 1 |
| Beardsley, GP; Forsch, RA; Lazarus, H; Rosowsky, A; Yu, CS | 1 |
| Abe, M; Abe, T; Adachi, H; Asano, N; Ito, S; Kasai, S; Matsuno, S; Mizutamari, H; Nishio, T; Onogawa, T; Satoh, F; Shimosegawa, T; Suzuki, M; Suzuki, T; Tanemoto, M; Tokui, T; Toyohara, T; Unno, M | 1 |
| Choi, L; Ho, RH; Schulte, RR; Stein, CM; Utreja, N; Van Driest, SL | 1 |
| Davis, SA; Feldman, SR; Krowchuk, DP | 1 |
| Cohen, IJ | 1 |
| Min, Y; Peng, L; Qiang, F; Zhu, Z | 1 |
| Guan, XQ; Huang, LB; Ke, ZY; Luo, XQ; Xu, L; Zhang, XL; Zhang, YC | 1 |
| Akaho, R; Akiyama, H; Hagiya, K; Mori, S; Nakagome, K; Sakamaki, H; Sasaki, T; Yoshino, M | 1 |
| BRESNICK, E; CERECEDO, LR | 1 |
| FREI, E; FREIREICH, EJ; MORSE, EE; RALL, DP; RIESELBACH, RE | 1 |
| BRADLEY, TR; HERZENBERG, LA; LAW, LW; ROOSA, RA | 1 |
| WILKINSON, JF | 1 |
| EVANS, AM; RIEKHOF, P | 1 |
| ROSS, ED; SETTLE, JA; TELFER, AB | 1 |
| ALBRECHT, M; ALENTY, A; BERTINO, JR; FREEMAN, M; GABRIO, BW; HUENNEKENS, FM; SILBER, R | 1 |
| MITANI, M; REISMAN, LE; ZUELZER, WW | 1 |
| CARPENTER, CM; MEYERS, RL; MILLER, JN | 1 |
| FEIWEL, M; MUNRO, DD | 1 |
| BALIS, ME; KRAKOFF, IH | 1 |
| CHATTERJEA, JB; GHOSE, S | 1 |
| CHITHAM, RG; MCIVER, EJ | 1 |
| WOODLIFF, HJ | 1 |
| BURCHENAL, JH; LYMAN, M; OETTGEN, HF; PURPLE, J | 1 |
| FREI, E; FREIREICH, EJ | 1 |
| GASSER, C | 2 |
| INNES, J | 1 |
| BELMUSTO, L; HANANIAN, J; NIGOGOSYAN, G; OWENS, G; REGELSON, W | 1 |
| REISMAN, LE; THOMPSON, RI; ZUELZER, WW | 1 |
| CORLEY, CC; HUGULEY, CM; LEA, JW; LOWREY, ME; VOGLER, WR | 1 |
| ANKER, HS; RENNERT, OM | 1 |
| BERNARD, J; BOIRON, M; BRIERE, J; DUMONT, J; LEVY, JP; MANUS, A | 1 |
| ZUELZER, WW | 1 |
| SATHE, Y; ZELEN, M; ZWEIFEL, J | 1 |
| ANDERSON, RE; MORROW, LB | 1 |
| KUNDEL, DW; NIES, BA | 1 |
| BRIGGS, GM; POTTER, M | 1 |
| Rajshekhar, V; Shah, KC | 1 |
| Baehring, JM; Fulbright, RK; Gorman, M; Haykin, ME; van Hoff, J | 1 |
| Kneba, M; Moosig, F; Schoch, R | 1 |
| Catovsky, D; Del Giudice, I; Grech, H; Matutes, E; Osuji, N; Swansbury, JG; Tjonnfjord, G; Wotherspoon, A | 1 |
| Gangjee, A; Kisliuk, RL; McGuire, JJ; Yang, J | 1 |
| Butterfield, J; Kantarjian, H; Ketterling, R; Pardanani, A; Tefferi, A; Vaklavas, C; Verstovsek, S | 1 |
| Hasegawa, Y; Izutsu, K; Kawa, K; Kim, WS; Kwong, YL; Nakamura, S; Okamura, T; Oshimi, K; Suzuki, R; Suzumiya, J; Yamaguchi, M | 1 |
| Freireich, EJ | 1 |
| Day, S; Ninane, J; Taylor, D | 1 |
| Cassady, JR; Freeman, AI; Frei, E; Green, DM; Hammond, D; Nesbit, ME; Sallan, SE; Sather, HN; Sinks, LF | 1 |
| Bridges, JM; Glasgow, JF; Pinkerton, CR; Welshman, SG | 2 |
| D'Angio, GJ; Hammond, GD; Littman, PS; Nesbit, ME; Ortega, J; Robison, LL; Sather, HN | 1 |
| Glasgow, JF; Pinkerton, CR | 1 |
| Fekete, G; Schuler, D; Szollár, J | 1 |
| Abromowitch, M; Bowman, WP; Chen, CH; Crom, WR; Evans, WE; Simone, JV; Stewart, CF | 1 |
| Adams, F; Andersson, BS; McCredie, KB | 1 |
| Abromowitch, M; Bowman, WP; Mason, C; Ochs, JJ; Pui, CH; Simone, JV | 1 |
| Bleyer, WA; Cohen, SR; Gangji, D; Poplack, DG; Reaman, GH | 1 |
| Jakó, J; Kiss, A; Rák, K | 1 |
| Kammerer, R; Mittler, U; Otto, HJ; Wittwer, B | 1 |
| Bertino, JR; Camitta, BM; Kamen, BA; Nylen, PA | 1 |
| Blau, HJ; Vergara-Domínguez, B | 1 |
| Cano, JP; Catalin, J; Fabre, G; Favre, R; Matherly, LH | 1 |
| Rosenblatt, DS; Whitehead, VM | 1 |
| Jannoun, L | 1 |
| Britton, PG; Craft, AC; Kernahan, J; Noble, TC; Twaddle, V | 1 |
| Bowman, WP; Campbell, M; Ch'ien, L; Coburn, T; Ochs, JJ; Parvey, LS; Whitaker, JN | 1 |
| Dietrich, J; Metz, O; Plenert, W | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 1 |
| Boivin, P; Courouble, Y; Elghozi, D; Gislon, J; Schuller, E; Solal-Celigny, P | 1 |
| Ibayashi, H; Inoue, T; Kaneko, S; Motomura, S; Nishimura, J; Sato, H; Simamoto, Y; Takeichi, N; Umemura, T | 1 |
| Hanefeld, F; Riehm, H | 1 |
| Chung, CK; Cruse, R; Stryker, JA; Towfighi, J; Vannuci, R | 1 |
| Metz, O; Stoll, W | 1 |
| Metz, O; Plenert, W; Stoll, W | 1 |
| Matsumura, T; Nishikawa, A; Ohnishi, T; Saito, K; Taniuchi, S | 1 |
| Fukumoto, M; Kimura, I; Kitajima, K; Lai, M; Nishimura, M; Oda, Y; Takahashi, I; Yorimitsu, S | 1 |
| Albo, V; Hammond, D; Karon, M; Leikin, S; Miller, DR; Sather, H | 1 |
| Herman, J; Katenkamp, D; Malke, H; Plenert, W; Zintl, F | 1 |
| Schöck, V | 1 |
| Cassady, JR; Frei, E; Gelber, R; Hitchcock-Bryan, S; Nathan, DG; Sallan, SE | 1 |
| Chabner, BA; Clendeninn, NJ; Cowan, KH; Curt, GA; Jolivet, J | 1 |
| Bleyer, WA; Coccia, PF; Leikin, SL; Level, C; Littman, PS; Lukens, J; Miller, DR; Niebrugge, DJ; Sather, HN; Siegel, S | 1 |
| Ernst, P; Møller, J; Panduro, J; Sørensen, PG | 1 |
| Frei, E | 1 |
| Fujimoto, T; Higashi, O; Imashuku, S; Koizumi, S; Mimaya, J; Ninomiya, T; Sekine, I; Shike, S; Utsumi, J; Yamamoto, S | 1 |
| Carey, RW; Cuttner, J; Ellison, RR; Gottlieb, AJ; Henderson, ES; Levy, RN; Rafla, S; Silver, RT; Terebelo, H; Weinberg, V | 1 |
| Costlow, ME; Kalwinsky, DK; Ochs, J; Pui, CH | 1 |
| Fujimoto, T; Hiyoshi, Y; Ito, M; Kadoya, S; Kawai, S; Nibu, K; Shingaki, Y | 1 |
| Borsi, J; Koós, R; Révész, T; Schuler, D | 1 |
| Fujimoto, T; Higashi, O; Hiyoshi, Y; Koizumi, S; Komazawa, M; Mimaya, J; Nishikawa, K; Sekine, I; Utsumi, J; Yanai, M | 1 |
| Grode, ML; Pressman, BD | 1 |
| Lilleyman, JS; Wyld, PJ | 1 |
| Azuma, I; Chatani, M; Hishikawa, Y; Inoue, T; Kondo, K; Kumano, M; Suyama, T; Tabata, S; Teshimá, T; Yabumoto, E | 1 |
| Leonidas, JC; Schwartz, AM | 1 |
| Mathe, G | 5 |
| Kvícala, V; Pribylová, O | 1 |
| Belli, JA; Cassady, JR; Clavell, LA; Hitchcock-Bryan, S; Inati, A; Sallan, SE; Sollee, N | 1 |
| Brecher, ML; Burgert, EO; Chevalier, L; Forman, E; Freeman, AI; Gilchrist, GS; Glicksman, AS; Hananian, J; Harris, M; Holland, JF; Jones, B; Kung, F; Leventhal, B; Maurer, H; Necheles, T; Patterson, RB; Pleuss, H; Sinks, LF; Weil, M; Weinberg, V | 1 |
| Burgdorf, WH; Humphrey, GB; Wheeland, RG | 1 |
| Balis, FM; Bleyer, WA; Savitch, JL | 1 |
| Baum, E; Griffin, T; Littman, P; Nachman, J; Neerhout, R; Norris, D; Ramsay, N; Sather, H; Weetman, B | 1 |
| Duque-Hammershaimb, L; Miller, DR; Wollner, N | 1 |
| Arizaga, R; Castaño, J; Chamoles, N; Fisman, N; Leiguarda, R; Moreno, R; Pavlovsky, S | 1 |
| Javier, G; Montagut, JM; Ortega, JJ | 1 |
| Braier, J; Dibar, E; Divito, JM; Eppinger-Helft, M; Failace, R; Garay, G; Jimenez, E; Kvicala, R; Muriel, FS; Pavlovsky, S; Svarch, E; Vergara, B | 1 |
| Dempsey, SI; Glasgow, JF; Pinkerton, CR | 1 |
| Hino, Y; Morimatsu, M; Mukae, T; Nagayama, K; Nakashima, A; Nakashima, T | 1 |
| Benoit, Y; Bury, J; Delbeke, MJ; Fière, D; Otten, J; Solbu, G; Stryckmans, PA; Suciu, S | 1 |
| Dörffel, W; Grulich, M; Reuter, G | 1 |
| Cherian, R; Lin, HP; Menaka, N; Singh, P; Sinnah, D | 1 |
| Moe, PJ; Vik, T | 1 |
| Gerecke, D; Hirschmann, WD; Kress, M | 1 |
| Gaedicke, G; Haas, RJ; Janka, G; Kohne, E; Netzel, B | 1 |
| Holcenberg, JS; Kamen, BA; Turo, K; Whitehead, VM | 1 |
| Valbuena Crespo, C | 1 |
| Cheng, YC; Grill, SP; Wells, RJ | 1 |
| Bercu, BB; Blatt, J; Gillin, JC; Mendelson, WB; Poplack, DG | 1 |
| Busch, U; Gadner, H; Haas, H; Höcker, P; Kärcher, KH; Krepler, P; Kummer, M; Kundi, M; Messner, H; Pawlowsky, J | 1 |
| Mahony, MJ; Mott, MG; Murphy, MS; Wadsworth, J | 1 |
| Doering, EJ; Frankel, LS; Nitschke, R; Pullen, J; Shuster, J; Wang, YM | 1 |
| Bowman, WP; Dahl, GV; George, SL; Hustu, HO; Kalwinsky, D; Ochs, J; Rivera, G; Simone, JV | 1 |
| Hiraishi, Y; Kuribayashi, T; Oshima, Y; Shitara, T | 1 |
| De Rossi, G; Iacobelli, S; Mandelli, F; Marchetti, P | 1 |
| Tricot, G; Van Hoof, A; Verwilghen, RL | 1 |
| Kawamura, S; Maekawa, I; Miyake, T; Sasaki, H | 1 |
| Barber, SW; Camitta, BM; Casper, JT; Kamen, BA; Kaplan, BM; Kline, RW; Kun, LE; Lauer, SJ; Mulhern, RK | 1 |
| Azuma, I; Chatani, M; Hishikawa, Y; Inoue, T; Kondo, K; Kumano, M; Nakajima, T; Suyama, T; Teshima, T; Yabumoto, E | 1 |
| Chessells, JM; Pinkerton, CR | 1 |
| Bidlingmaier, F; Haas, RJ; Helmig, M; Janka, GE; Mack, R | 1 |
| Hammond, GD; Meadows, AT; Nesbit, ME; Ortega, JA; Robison, LL; Sather, HN | 1 |
| Gaukroger, JM; Wilson, L | 1 |
| Hanefeld, F; Harten, G; Henze, G; Langermann, HJ; Riehm, H; Stephani, U | 1 |
| Cano, JP; Catalin, J; Fabre, G; Just, S | 1 |
| Blakley, RL; Newton, PA | 1 |
| Hermann, T; Michalewska, D; Skibińska, L; Szwarc, E | 1 |
| Chessells, J; Leiper, A; Rogers, D | 1 |
| Bökkerink, JP; De Abreu, RA; De Bruyn, CH; De Vaan, GA; Lippens, RJ; Schouten, TJ; Van Laarhoven, JP | 1 |
| Boiron, M; Janvier, M; Leverger, G; Poirier, O; Renier, D; Tobelem, G | 1 |
| Chello, PL; Hancock, C; Miller, DR; Miller, LP; Sirotnak, FM; Tan, CT | 1 |
| Javier, G; Ortega, JJ; Torán, N | 1 |
| Berman, A; Brecher, ML; Forman, E; Glicksman, AS; Glidewell, OJ; Harris, M; Holland, JC; Rowland, JH; Sibley, RF; Tull, R | 1 |
| Behrendt, H | 1 |
| Benedetti, P; Cristiani, ML; Crocioni, F; De Giorgis, G; Galletti, F; Moleti, L; Sturniolo, MG | 1 |
| Hatakeyama, S; Okeda, R; Suzuki, K; Takemura, T | 1 |
| Amigó, V; Gomis, F; Lorenzo, I; Martín-Aragonés, G; Martínez, JA; Marty, ML; Rafecas, FJ; Sanz, G; Sanz, MA | 1 |
| Hamborg-Pedersen, B; Lund, E | 1 |
| Bowman, WP; Cairnes, DA; Crom, WR; Evans, WE; Hutson, PR; Rivera, G; Stewart, CF | 1 |
| Farid, Y; Gaukroger, J; Habeshaw, T; Harding, N; Mackie, R; Stewart, M; Wilson, L | 1 |
| Fujimoto, T | 3 |
| Fujimoto, T; Kinpara, H; Sasaki, K; Tanaka, J | 1 |
| Pozzi, DH | 1 |
| Abels, J; Dekker, A; Goudsmit, R; Haanen, C; Kerkhofs, H; Kurstjens, R; Roozendaal, KJ; Sizoo, W; Tricot, G; von dem Borne, A; Willemze, R | 1 |
| Baĭdun, LV; Dorofeeva, NK; Izotova, TA; Kisliak, NS; Rumiantsev, AG | 1 |
| Haas, RJ; Helmig, M; Janka, GE; Netzel, B | 1 |
| Fletcher, R; Gober, J; Hande, K | 1 |
| Carpentier, Y; Desoize, B; Jardillier, JC; Kouamouo, J; Trentesaux, C | 1 |
| Chevalier, LM; Dubé, J; Esseltine, DW; Freeman, CR; Nogrady, MB; O'Gorman, AM; Smith, R; Whitehead, VM | 1 |
| Hennemann, HH; Lengfelder, E; Mantel, W; Ranft, K; Weiss, A | 1 |
| Grossman, SA; Murray, K; Thompson, G; Trump, DL | 1 |
| Goldschmidt, B; Koós, R | 1 |
| Antonelli, M; Giona, F; Loasses, A; Mandelli, F; Montuoro, A; Prencipe, M; Sideri, G | 1 |
| Chessells, JM | 1 |
| Kardos, G; Révész, T; Schuler, D; Vargha, M | 1 |
| Chessells, JM; Sandland, RM; Tiedemann, J | 1 |
| Liepman, MK; Votaw, ML | 1 |
| Levine, AM; Todd, JA; Tökés, ZA | 1 |
| Grisold, W; Lutz, D; Wolf, D | 1 |
| Castel, V; Ferris, J; Prats, C | 1 |
| Abelson, HT; Beltz, WR; Frei, E; Lazarus, H; Mangini, L; Modest, EJ; Rosowsky, A; Yuan, GC | 1 |
| Bennett, AJ; Chessells, JM; Cornbleet, MA; Hardisty, RM; Rapson, NT | 1 |
| Berger, P; Brecher, ML; Freeman, AI; Kinkel, W; Ochs, JJ; Sinks, LF | 1 |
| Bate, CM; Craft, AW; Graham-Pole, J; Malpas, JS; Parker, D; Stansfeld, AG | 1 |
| Maiakova, SA; Makhonova, LA | 2 |
| Rumiantsev, AG | 1 |
| Borisov, BN; Fedorov, NA; Oan', NF; Sevast'ianova, MG; Skotnikova, OI | 1 |
| Caspers, S; Franke, HD; Grosch-Wörner, I; Hess, A; Kabisch, H; Landbeck, G; Langendorff, G; Marsmann, G; Matzke, E; Meissner, C; Müller, J; Winkler, K | 1 |
| Korinthenberg, R; Palm, D | 1 |
| Al-Rashid, RA; Bloch, S; Smith, D | 1 |
| Aur, RJ; Avery, TL; Bowman, WP; Dahl, GV; Rivera, G; Wood, A | 1 |
| Creutzig, U; Schellong, G | 1 |
| Avenarius, HJ; Engelhardt, P; Lorenz, R | 1 |
| Choudhry, VP; Saraya, AK; Singh, P | 1 |
| Bridges, JM; Dempsey, SI; Glasgow, JF; Pinkerton, CR; Welshman, SG | 1 |
| Gadner, H; Hanefeld, F; Müller, S; Rating, D; Riehm, H; Siegert, M; Siemes, H | 1 |
| Damle, SR; Gadgil, SD; Jussawalla, DJ; Shetty, PA | 1 |
| Nesbit, ME; O'Leary, M; Woods, WG | 1 |
| Herson, J; Kimball, JC; Sullivan, MP | 1 |
| Berenson, RJ; Bertino, JR; Dolnick, BJ; Francke, U | 1 |
| Aur, RJ; Ch'ien, LT; Coburn, TP; Goff, JR; Hustu, HO; Price, RA; Seifert, MJ; Simone, JV; Verzosa, MS | 1 |
| Bowman, WP; Brodeur, GM; Kalwinsky, DK; Look, AT; Williams, DL | 1 |
| Bogáthy, B; Koós, R; Schuler, D; Szakmáry, E; Szollár, J | 1 |
| Thompson, EN | 1 |
| Auclerc, MF; Bernard, J; Jacquillat, C; Schaison, G; Weil, M | 1 |
| Moss, HA; Nannis, ED; Poplack, DG | 1 |
| Boiadzhiev, P; Petkova, R; Vasilev, N | 1 |
| Glass, PJ; Ostrow, PT; Shalen, PR | 1 |
| Javier, G; Ortega, JJ | 1 |
| Bridges, JM; Glasgow, JF; Gwavava, NJ; Pinkerton, CR; Sloan, JM | 1 |
| Haas, RJ; Helmig, M; Janka, G; Netzel, B | 1 |
| Caspers, S; Erttmann, R; Grosch-Wörner, I; Kabisch, H; Landbeck, G; Matzke, E; Müller, J; Winkler, K | 1 |
| Mazur, H; Silwa, F; Sońta-Jakimczyk, D | 1 |
| Akao, Y; Hiraiwa, A; Naito, K; Nakamara, K; Naoe, T; Uno, H; Yamaguchi, H; Yoshikawa, H; Yoshikawa, S | 1 |
| Finney, R; Proctor, SJ; Thompson, RB; Walker, W | 1 |
| Gledhill, RM; Norman, MR | 1 |
| Clausen, N; Pedersen, H | 2 |
| Hoffbrand, AV; Taheri, MR; Wickremasinghe, RG | 2 |
| Fülle, HH; Koeppen, KM; Rühl, H; Schwerdtfeger, R | 1 |
| Mardiak, J; Reiner, P; Reinerová, M; Ujházy, V | 1 |
| Freeman, AI; Sinks, LF; Wang, JJ | 3 |
| Derulska, D; Kansy, J; Makowska, K; Rokicka-Milewska, R; Skrobowska-Woźniak, A | 1 |
| Aherne, W; Craft, AW; Rankin, A | 1 |
| Bleyer, WA | 1 |
| Bodey, GP; Freireich, EJ; Keating, MJ; McCredie, KB; Yap, BS | 1 |
| Finne, PH; Moe, PJ; Seip, M | 2 |
| Breton, MP; Cau, D; Dommergues, JP; Jacque, C; Laurian, Y; Tchernia, G | 1 |
| Fauchon, F; Merle-Béral, H; Touboul, E | 1 |
| Weil, M | 1 |
| Auclerc, MF; Bernard, J; Chastang, C; Jacquillat, C; Schaison, G; Weil, M | 1 |
| Ise, T | 1 |
| Honig, G; Morgan, E; Nelson, DJ | 1 |
| Bridges, JM; Pinkerton, CR; Welshman, SG | 1 |
| Auriti, L; Bracchi, M; De Grandi, C; Masera, G; Scotti, G; Uderzo, C | 1 |
| Bachmann, KD; Gröbe, H; Menne, R; Müller, KM | 1 |
| Baba, Y; Hoshizaki, H; Niki, Y | 1 |
| Birman, V; Braier, JL; Bustelo, P; Dibar, E; Divito, J; Eppinger-Helft, M; Failace, R; Garay, G; Kvicala, R; Pavlovsky, S; Peñalver, J; Sackmann Muriel, F; Svarch, E; Vergara, B | 1 |
| Amadori, S; Baccarani, M; Cardozo, PL; Corbelli, G; Drenthe-Schonk, A; Haanen, C; Mandelli, F; Meloni, G; Tura, S; Willemze, R | 1 |
| Correra, A; De Masi, RV; Florino, G; Lagonigro, F; Saviano, P; Tontoli, N; Vetrella, A | 1 |
| Bowman, WP; Brodeur, GM; Dahl, GV; Kalwinsky, DK; Look, AT; Melvin, SL; Rivera, G; Tsiatis, A; Williams, DL | 1 |
| Chen, T; Dyment, PG; Hvizdala, E; Steuber, CP; Sullivan, MP | 1 |
| Chervinsky, DS; Creaven, PJ; Ettinger, LJ; Freeman, AI | 1 |
| Ghavimi, F; Miller, DR; Murphy, ML; Nir, Y; Salwen, R; Tamaroff, M | 1 |
| Feldges, A; Imbach, P; Lüthy, A; Plüss, HJ; Sartorius, J; Wagner, HP; Wyss, M | 1 |
| Gadner, H; Krepler, P; Kundi, M; Mutz, I; Pichler, E; Schmidmeier, W; Tulzer, W; Urban, C | 1 |
| Hess, CE; Zirkle, JW | 1 |
| Anelli, G; Camatini, M; de Curtis, I; Franchi, E; Masera, G | 1 |
| Blumenson, LE; Brecher, ML; Freeman, AI; Green, DM; Grossi, M | 1 |
| Francis, PR; Slowiaczek, P; Tattersall, MH; Taylor, IW | 1 |
| Cameron, CH; Glasgow, JF; Gwevava, NJ; Pinkerton, CR; Sloan, JM | 1 |
| Bowman, WP; Cairnes, DA; Crom, WR; Evans, WE; Hutson, PR; Stewart, CF; Yee, GC | 1 |
| Alessandrino, EP; Bernasconi, C; Brusamolino, E; Canevari, A; Castelli, G; Isernia, P; Lazzarino, M; Morra, E; Orlandi, E; Pagnucco, G; Salvaneschi, L; Zei, G | 1 |
| Carnot, J; Cristo, E; Eppinger-Helft, M; Fernández, O; García, O; González, A; Hernández, P; Mendez, J; Pavlovsky, S; Sackmann-Muriel, F; Svarch, E; Vergara, B | 1 |
| Bridges, JM; Kelly, JG; Pinkerton, CR; Shanks, RG; Welshman, SG | 1 |
| Laosombat, V; Mitarnun, W; Mo- suwan, L; Wacharasin, R | 1 |
| Sullivan, MP | 1 |
| Choudhry, VP; Marwaha, RK | 1 |
| Fujimoto, T; Hasegawa, K; Hiyoshi, Y; Ito, M; Kadoya, S; Kawai, S; Koizumi, S; Komazawa, M; Kuriya, N; Mimaya, J; Sasaki, K; Shingaki, Y; Yokoyama, T | 1 |
| Tan, CL | 1 |
| Abe, Y; Asakura, A; Endo, N | 1 |
| Ito, H; Ohsumi, A; Ohta, Y; Ohyashiki, J; Ohyasiki, K; Osamura, S; Tomita, T; Umehara, S; Yunokawa, K | 1 |
| de Vassal, F; Delgado, M; Gil-Delgado, MA; Goutner, A; Machover, D; Mathé, G; Misset, JL | 1 |
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| Cucchi, CA; Flatow, J; Frei, E; Rosowsky, A; Trites, D; Waxman, DJ; Wright, JE | 1 |
| Fried, M; Ilardi, CF; Kalra, J; Sawitsky, A | 1 |
| Beaulieu, D; Rosenblatt, DS; Vuchich, MJ; Whitehead, VM | 1 |
| Fogh, K; Herlin, T; Schrøder, H | 1 |
| Fogh, K; Schrøder, H | 1 |
| Bates, SE; Cohen, S; McKeever, P; Poplack, DG; Price, RA; Raphaelson, MI | 1 |
| Dolan, G; Lilleyman, JS; Richards, SM | 1 |
| Anderson, LJ; Cera, PJ; Gary, GW; Lobel, JS; Shah, NR; Smith, MA | 1 |
| Faulkner, G; Fernandez, LA; Ghose, T; Lee, CL; Lee, SH | 1 |
| Champagne, J; Hoyoux, C; Infante-Rivard, C; Rivard, GE | 1 |
| Bailleul, F; Lévi, F; Mathe, G; Misset, JL; Reinberg, A | 1 |
| Albo, V; Blatt, J; Orlando, S; Prin, W; Wollman, M | 1 |
| Lejeune, J; Peeters, MA; Poon, A; Zipursky, A | 1 |
| Holland, JF; Kano, Y; Ohnuma, T | 1 |
| Blattner, SR; Cassady, JR; Clavell, LA; Cohen, HJ; Gelber, RD; Hitchcock-Bryan, S; Leavitt, P; Sallan, SE; Tantravahi, R; Tarbell, NJ | 1 |
| Sanders, JE | 1 |
| Abromowitch, M; Crom, WR; Dodge, R; Evans, WE; Garré, ML; Kalwinsky, D; Pui, CH; Relling, MV | 1 |
| Kanellos, J; McKenzie, IF; Pietersz, GA | 1 |
| Erdohazi, M; Lumley, H; Malone, M | 1 |
| Ford, D; Kwan, YL; Lam-Po-Tang, PR; Mameghan, H; O'Gorman-Hughes, DW; Vowels, MR; White, L; Ziegler, JB | 1 |
| Hoshi, N; Kato, S; Kimura, M; Muranaka, S; Nagasaka, M; Yabe, H | 1 |
| Singh, AK; Thompson, RP | 1 |
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| Javier, G; Olive, T; Ortega, JJ | 1 |
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| Jakubovicz, D; Koren, G; Peeters, M; Zipursky, A | 1 |
| Burkey, E; Burroughs, B; Lange, BJ; Meadows, AT | 1 |
| Christensen, ML; Crom, WR; Evans, WE; Hancock, ML; Rivera, GK | 1 |
| Alexander, MS; Balis, FM; Jarosinski, PF; Lesko, LJ; Moscow, JA; Poplack, DG | 1 |
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| Flodmark, O; Poskitt, KJ; Steinbok, P | 1 |
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| Brinch, L; Evensen, SA; Stavem, P | 1 |
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| Fujimoto, T; Koizumi, S; Mimaya, J; Ninomiya, T; Takeda, T; Utsumi, J; Yanai, M; Yatabe, M | 1 |
| Abromowitch, M; Fairclough, D; Murphy, SB; Ochs, J; Pui, CH; Rivera, GK | 1 |
| Bökkerink, JP; de Abreu, RA; de Vaan, GA; Lippens, RJ; Schouten, TJ | 1 |
| Carlin, J; Deeg, HJ; McGuire, TR; Sanders, JE; Self, SG; Yee, GC | 1 |
| Dauriac, C; David, B; Extra, JM; Fiere, D; Gastaut, JA; Marty, M; Pris, J; Vernand, JP; Witz, F | 1 |
| Andrien, JM; Bitar, N; Bury, J; De Witte, T; Debusscher, L; Marie, JP; Peetermans, M; Solbu, G; Stryckmans, P; Suciu, S | 1 |
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| Malke, H; Plenert, W; Zintl, F | 1 |
| Bleyer, WA; Coccia, P; Hammond, D; Littman, P; Lukens, J; Miller, D; Sather, H; Siegel, S | 1 |
| D'Angio, GJ; Hammond, GD; Nesbit, ME; Ortega, JA; Robison, LL; Sather, HN | 1 |
| D'Angio, G; Goldwein, JL; Meadows, AT; Packer, RJ; Rorke, LB | 1 |
| Curtis, JE; Jamal, N; Lepine, J; Lockwood, G; Messner, HA; Minden, MD; Takahashi, T; Tritchler, D; Tweeddale, M; Wandl, U | 1 |
| Bouffet, E; Frappaz, D | 1 |
| Amineddine, HA; Chessells, JM; Craft, AW; Long, DR; Mills, S; Pearson, AD | 1 |
| Fujimoto, T; Kaneko, A; Katou, K; Koizumi, S; Kubota, H; Sekine, I; Takeda, T; Takeshita, T; Utsumi, J; Yatabe, M | 1 |
| Behar, C; Benoit, Y; Boilletot, A; Casteels-Van Daele, M; Chantraine, JM; Delbeke, MJ; Gyselinck, G; Hainaut, H; Lutz, P; Maurus, R | 1 |
| Borsi, JD; Moe, PJ | 3 |
| Holland, JF; Kano, Y; Ohnuma, T; Okano, T | 1 |
| Ablin, A; Brant-Zawadzki, M; Kramer, JH; Moore, IM; Norman, D | 1 |
| Fairclough, D; Mulhern, RK; Ochs, J; Wasserman, AL | 1 |
| Bowman, WP; Dodge, RK; Ochs, J; Pui, CH; Rivera, GK | 1 |
| Hijiya, N; Ise, T; Kanagawa, S; Kitabayashi, T; Matsushita, T; Yamaguchi, M | 1 |
| Alvarado, C; Brynes, RK; Chan, WC; Hargreaves, HK; Kim, TH; Ragab, AH; Woodard, J | 1 |
| Abromowitch, M; Bowman, WP; Crom, WR; Dodge, R; Evans, WE; George, SL; Look, AT; Pui, CH | 1 |
| Clausen, N; Ostergaard, E; Pressler, T; Schrøder, H | 1 |
| Borsi, J; Révész, T; Schuler, D | 1 |
| Chessells, JM; Mills, S; Pinkerton, CR | 1 |
| Balis, FM; Poplack, DG; Zimm, S | 1 |
| Camitta, BM; Casper, J; Holcenberg, JS; Kamen, BA; Lauer, S | 1 |
| Bernasconi, C; Brusamolino, E; Canevari, A; Inverardi, D; Lazzarino, M; Morra, E; Orlandi, E; Pagnucco, G | 1 |
| Maaser, M; Metz, O | 1 |
| Fiandino, G; Iannacci, L; Lange, MM; Madon, E; Messina, M; Miniero, R; Pastore, G; Saracco, P | 1 |
| Secker-Walker, LM; Stewart, EL | 1 |
| Lasorella, A; Mastrangelo, R; Riccardi, R | 1 |
| Abromowitch, M; Dahl, GV; George, SL; Kalwinsky, DK; Look, AT; Mirro, J; Ochs, JJ; Pui, CH; Rivera, GK; Williams, D | 1 |
| Kolmannskog, S; Moe, PJ; Wesenberg, F | 1 |
| Finne, PH; Kolmannskog, S; Moe, PJ; Seip, M | 2 |
| Anderson, K; Berenberg, JL; Cooper, RM; Cuttner, J; Faso, L; Terebelo, HR; Wiernik, PH | 1 |
| Chessells, J; Leiper, AD | 1 |
| Borsi, J; Kardos, G; Koós, R; Révész, T; Schuler, D; Somló, P | 1 |
| Fujimoto, T; Kawai, S | 1 |
| Schrøder, H | 2 |
| Karube, T; Miyao, M; Muchi, H; Satoh, T; Yamamoto, K | 1 |
| Fujimoto, T; Matsuoka, H; Sasaki, K | 1 |
| Fujimoto, T; Kadoya, S; Koizumi, S; Mimaya, J; Miyao, M; Ninomiya, T; Nishikawa, K; Tsuda, Y; Utsumi, J; Yatabe, M | 1 |
| Hirose, M; Miyao, M; Ninomiya, T; Sato, J; Tanaka, H; Yuasa, Y | 1 |
| Abeel, MJ; Forman, EN; Krumm, KF; Martin, HF; Parker, RI | 1 |
| Chessells, JM; Hardisty, RM; Leiper, AD; Richards, S; Tiedemann, K | 1 |
| Balis, FM; Collins, JM; Gilchrist, GS; Hammond, D; Holcenberg, JS; Murphy, RF; Poplack, DG; Tubergen, D; Zimm, S | 1 |
| Grau-Oliete, MR; Rivera-Fillat, MP; Soriano, L | 1 |
| Russo, A; Schiliro, G | 1 |
| Meadows, AT; Packer, RJ; Rorke, LB; Wizniter, M | 1 |
| Choi, KE; Crom, WR; Evans, WE; Mirro, J; Teresi, ME | 1 |
| Hülsen, H; Mechelke, F | 1 |
| Borsi, JD; Revesz, T; Schuler, D | 1 |
| Saarinen, UM | 1 |
| Brandeis, WE; Calvo, W; Kober, B; Ludwig, R | 1 |
| Davis, KS; Fairclough, D; Mulhern, RK; Ochs, J; Wasserman, AL; Williams, JM | 1 |
| Abromowitch, M; Dahl, GV; Dodge, RK; Hustu, HO; Kalwinsky, DK; Look, AT; Mirro, J; Murphy, SB; Ochs, J; Rivera, GK | 1 |
| Amadori, S; Fontana, M; Mandelli, F; Meloni, G; Pompili, A; Riccio, A; Rubinstein, LJ; Stanton, C | 1 |
| Hählen, K; Nooter, K; Schultz, F; Sonneveld, P | 1 |
| Goebel, U; Janka, GE; Juergens, H; Winkler, K | 1 |
| Ariyoshi, N; Fujimoto, T; Hiyoshi, Y; Kawai, S; Koizumi, S; Komazawa, M; Mimaya, J; Tanaka, K; Yaoi, K; Yatabe, M | 1 |
| Henderson, GB; Kumar, HP; Tsuji, JM | 1 |
| Deville, A; Manassero, J; Milano, G; Renee, N; Schneider, M; Thyss, A | 1 |
| Reddemann, H; Riethdorf, L; Schwesinger, G | 1 |
| Christensen, R; Nemcek, AA; Pollei, SR | 1 |
| Brandeis, WE; Frei, E; Kimmig, B; Ludwig, R | 1 |
| Bleyer, WA; Feusner, JH; Miser, JS; Poplack, DG; Reaman, GH; Tanyer, G; Weber, BL | 1 |
| Abromowitch, M; Bowman, WP; Crom, WR; Dodge, R; Evans, WE; Ochs, J; Pui, CH; Relling, MV | 1 |
| Harnett, AN; Plowman, PN | 1 |
| Sonneveld, P; van der Steuijt, K | 1 |
| Castel, V; Esquembre, C; Ferris, J; Verdeguer, A | 1 |
| Muchi, H; Satoh, T; Taniguchi, Y | 1 |
| Chiba, Y; Haneda, Y; Iwamura, H; Kawamura, S; Mikami, T; Sakata, Y; Sawada, Y; Yamaya, T; Yoshida, Y | 1 |
| Higashi, O; Inugami, A; Kanno, I; Komatsu, K; Murakami, M; Ogawa, T; Shishido, F; Uemura, K; Yamaguchi, T | 1 |
| Abromowitch, M; Berard, CW; Bowman, WP; Fairclough, D; Mirro, J; Murphy, SB; Ochs, J; Pui, CH; Rivera, G | 1 |
| Borella, LD; Buchanan, GR; Casper, JT; Cornet, JM; Hoffman, RG; Krance, R; Kun, LE; Lauer, SJ; Pinkel, D; Sartain, P | 1 |
| Buckner, CD; Flournoy, N; Sanders, JE; Thomas, ED; Thompson, CB | 1 |
| Arlin, Z; Gee, T; Higgins, C; Kempin, S; Koziner, B; McKenzie, S; Mertelsmann, R; Schauer, P; Slater, DE; Straus, D | 1 |
| Javier, G; Montagut, JM; Ortega, JJ; Torán, N | 1 |
| Abromowitch, M; Crom, WR; Dodge, R; Evans, WE; Glynn, AM; Pui, CH | 1 |
| Bleyer, A; Evans, RG; Finklestein, J; Gaynon, P; Meyers, P; Miller, DR; Reaman, G; Sather, H; Steinherz, LJ; Steinherz, PG | 1 |
| Bruner, J; Fields, WS; Glass, JP; Lee, YY | 1 |
| Bell, BA; Whitehead, VM | 1 |
| Brecher, ML | 1 |
| Abbott, GD; Allen, JR; Beard, ME; Hart, DN; Heaton, DC; Heslop, HE | 1 |
| Lampkin, BC; Wong, KY | 1 |
| Boyett, JM; Brecher, ML; Freeman, AI; Glicksman, A; Holland, JF; Jones, B; Sinks, LF; Weinberg, V | 1 |
| Goebel, U; Gutjahr, P; Janka-Schaub, GE; Jürgens, H; Spaar, HJ; Winkler, K | 1 |
| Chessells, JM; Durrant, J; Hardy, RM; Richards, S | 1 |
| Russo, A; Schiliro', G | 1 |
| Gumbart, CH; Stagg, MP | 1 |
| Bertino, JR; Carman, MD; Medina, WD; Mini, E; Moroson, BA; Srimatkandada, S | 1 |
| Bertino, JR; Franco, CT; Mini, E; Moroson, BA | 1 |
| Balis, F; Bleyer, A; Feusner, J; Miser, J; Morse, M; Poplack, D; Reaman, G; Savitch, J | 1 |
| Gudauskas, G; Rootman, J | 1 |
| Armitage, JO; Aunan, SB; Burns, CP; Dick, FR; Edwards, RW; Gingrich, RD; Leimert, JT; Maguire, LC | 1 |
| Ceci, A; Colella, R; Livrea, P; Logroscino, GC; Lojacono, G; Pisicchio, L; Simone, IL; Trojano, M; Zimatore, GB | 1 |
| Holland, JF; Kamen, BA; Lo, RJ; Ohnoshi, T; Ohnuma, T; Scanlon, KJ; Wolman, SR | 1 |
| Balis, FM; Bleyer, WA; Poplack, DG; Reaman, GH; Savitch, JL | 1 |
| Headon, B; O'Meara, A; Reen, DJ | 1 |
| Aherne, GW; Campbell, AN; Craft, AW; Eastham, EJ; Littleton, P; Pearson, AD; Pearson, GL | 1 |
| Aur, RJ; Berg, R; Hustu, HO; Ochs, JJ; Rivera, G; Simone, JV | 1 |
| Brouwers, P; Fedio, P; Poplack, DG; Riccardi, R | 1 |
| Berry, DH; Boyett, JM; Castleberry, RP; Culbert, S; Glicksman, AS; Humphrey, GB; Land, VJ; Thomas, PR; Vats, T | 1 |
| Cairncross, JG; Farrell, M; Pexman, W | 1 |
| Bodenstein, H; Büchner, T; Engelhardt, R; Ganser, A; Hoelzer, D; Löffler, H; Messerer, D; Rühl, H; Thiel, E; Zwingers, T | 1 |
| Barnett, MJ; Biruls, R; Ganesan, TS; Lister, TA; Miller, A; Richards, MA; Rohatiner, AZ; Waxman, JH | 1 |
| Galicich, J; Jereb, B; Steinherz, P | 1 |
| Berger, P; Boyett, J; Brecher, ML; Cohen, ME; Foreman, E; Freeman, AI; Glicksman, AS; Harris, M; Jones, B; Krischer, J | 1 |
| Hara, T; Ishii, E; Kishida, K; Miyazaki, S; Nakamura, E; Ueda, K; Yoshida, N | 1 |
| Consoli, G; Marina, R; Pero, G; Rizzari, C; Russo, A; Schilirò, G; Tomarchio, S | 1 |
| Carli, M; Casara, GL; Deambrosis, G; Drigo, P; Laverda, AM; Marin, G; Perilongo, G; Sotti, G; Zanesco, L | 1 |
| Balakirev, SA; Drozdova, TS; Gavrilova, IE; Maiakova, SA; Makhonova, LA | 1 |
| Arkavina, EA; Berliner, GB; Mendeleev, IM; Polezhaev, IuN | 1 |
| Advani, SH; Dinshaw, KA; Gopal, R; Kamat, DM; Nadkarni, KS; Nair, CN; Rao, DN; Saikia, TK | 1 |
| Bessho, F | 1 |
| Barbet, J; Cano, JP; Gastaut, JA; Imbert, AM; Lejeune, C; Lena, N; Maraninchi, D; Sainty, D; Sebahoun, G; Tubiana, N | 1 |
| Wachowiak, J | 1 |
| Thiel, HJ | 1 |
| Ijima, H; Karube, T; Muchi, H | 1 |
| Baer, MR; Flexner, JM; Stein, RS | 1 |
| Kurkure, PA; Pai, SK; Pai, VR; Sanchetee, SC; Shetty, PA | 1 |
| Pees, HW; Riehm, HJ; Schwamborn, J | 1 |
| Lokey, JL; Pecora, M; Steinberg, JP | 1 |
| Fujimoto, T; Katano, N; Matsuoka, H; Sasaki, K; Tsurusawa, M | 1 |
| Bandini, G; Cantore, M; Fiacchini, M; Gherlinzoni, F; Lauria, F; Mazza, P; Pileri, S; Poletti, G; Tura, S | 1 |
| Ausserer, B; Bettelheim, P; Gadner, H; Grienberger, H; Grümayer, ER; Haas, OA; Krepler, P; Kummer, M; Pawlovsky, J; Schmidmeier, W | 1 |
| Bodey, GP; Freireich, EJ; Hurtubise, M; Keating, MJ; Leavens, M; Maor, M; McCredie, KB; Smith, TL; Stewart, DJ | 1 |
| George, SL; Mauer, AM; Ochs, JJ; Simone, JV | 1 |
| Appelbaum, FR; Buckner, CD; Clift, RA; Deeg, HJ; Flournoy, N; Lum, LG; Sanders, JE; Stewart, P; Sullivan, KM; Thomas, ED | 1 |
| Brix, F; Dühmke, E; Euler, HH; Gassmann, W; Gremmel, H; Hebbinghaus, D; Kayser, W; Schaub, J; Schmitz, N; Wüstemann, M | 1 |
| Blume, KG; Findley, DO; Forman, SJ; Henke, M; Hill, LR; Krance, RA | 1 |
| Dickinson, A; Fail, B; Finney, R; Hamilton, PJ; Paul, B; Proctor, SJ; Reid, MM; Saunders, P; Taylor, P; Thompson, RB | 1 |
| Freeman, AI | 2 |
| Abromowitch, M; Dahl, GV; Dow, LW; Evans, WE; Kalwinsky, DK; Look, AT; Mirro, J; Ochs, J; Pui, CH; Rivera, GK | 1 |
| Cáp, J; Cinkovská, S; Foltinová, A; Misíková, Z; Szabová, I | 1 |
| Gupta, SP; Handa, A; Prabhakar, YS | 1 |
| Brachet, J; Hulin, N; Masera, P; Pileri, A | 1 |
| Bernard, J; Boiron, M; Jacquillat, C; Weil, M | 2 |
| Baum, ES; Corby, DG; Koch, HF; Plunket, DC | 1 |
| Collica, F; Mollica, F; Pavone, L; Schilirò, G | 1 |
| Collins, CD; Firth, JL; Spiers, AS | 1 |
| Hartwich, G; Soyka, D; Taghavy, A | 1 |
| Mott, MG; Stevenson, P; Wood, CB | 1 |
| Burchenal, JH; Dowling, MD; Tan, CT | 1 |
| Whitcomb, ME | 1 |
| Booth, AE; Spiers, AS | 1 |
| Jensen, KB; Petersen, JH; Reske-Nielsen, E; Sogaard, H | 1 |
| Grignani, F; Martelli, M; Tonato, M | 1 |
| Aur, RJ; Daniels, S; Feldges, AJ; Verzosa, MS | 1 |
| Haas, H; Kurz, R | 1 |
| Abbrederis, K; Schmalzl, F | 1 |
| Danieli, G | 1 |
| Buckner, CD; Clift, RA; Fass, L; Fefer, A; Lerner, KG; Neiman, P; Rowley, N; Storb, R; Thomas, ED | 1 |
| Speck, B | 1 |
| Buckner, CD; Fefer, A; Glucksberg, H; Lerner, KG; Neiman, P; Storb, R; Thomas, ED | 1 |
| Bryant, JI; Buckner, CD; Clift, RA; Fefer, A; Fialkow, PJ; Funk, DD; Neiman, PE; Rudolph, RH; Slichter, SJ; Storb, R; Thomas, ED | 1 |
| Buckner, CD; Clift, RA; Fefer, A; Glucksberg, H; Lerner, KG; Neiman, P; Storb, R; Thomas, ED | 1 |
| Buckner, CD; Clift, RA; Fefer, A; Glucksberg, H; Lerner, KG; Neiman, PE; Storb, R; Thomas, ED | 1 |
| Mathé, G; Schwarzenberg, L | 1 |
| Abeloff, MD; Anderson, PN; Bias, WB; Borgaonkar, DS; Braine, HG; Burke, PJ; Davis, TE; Humphrey, RL; Mullins, GM; Santos, GW; Sensenbrenner, LL; Slavin, RE; Tutschka, PJ | 1 |
| Alter, HJ; Bleyer, WA; Buja, ML; Bull, JM; Bull, MI; Decter, J; Gralnick, HR; Graw, RG; Henderson, ES; Herzig, GP; Herzig, RH; Kirkpatrick, CH; Krueger, GR; Leventhal, BG; Lohrmann, HP; McGinniss, MH; Whang-Peng, J; Yankee, RA | 1 |
| Amiel, JL; Cattan, A; Hayat, M; Jasmin, C; Mathé, G; Schlumberger, JR; Schneider, M; Schwarzenberg, L | 1 |
| Grignani, F; Martelli, MF; Tonato, M | 1 |
| Breidenbach, H; Weissbach, G | 1 |
| Back, EH | 1 |
| Kagen, M; Lee, SL; Morrison, AN; Rosner, F | 1 |
| Butcher, DM; Hardisty, RM; Lange, L; Pampiglione, G | 1 |
| Honig, GR; Mason, RG; Vida, LN | 1 |
| Chen, KK; Rosowsky, A | 1 |
| Frei, E; Freireich, EJ; Oppenheim, JJ; Tjio, JH; Whang-Peng, J | 1 |
| Boisseau, M; Labatut, M; Moreau, F; Roulaud, F | 1 |
| Halterman, RH; Herberman, RB; Leventhal, BG; McCoy, JL; Rosenberg, EB | 1 |
| Halterman, RH; Henderson, ES; Herberman, RB; LePourhiet, A; Leventhal, BG | 1 |
| Bryan, JH; Johnson, GE; Leventhal, BG | 1 |
| Sanada, H; Taguchi, H | 1 |
| Adamson, RH; Henderson, ES; Oliverio, VT | 1 |
| Amiel, JL; Cattan, A; Mathé, G; Schlumberger, JR; Schneider, M; Schwarzenberg, L | 1 |
| Zubrod, CG | 4 |
| Croizat, P; Fière, DM; Revol, L; Viala, JJ | 1 |
| Amiel, JL; Clarysse, A; Hayat, M; Mathé, G; Schneider, M; Schwarzenberg, L | 1 |
| Bauters, F; Goudemand, M; Lerche, B | 2 |
| Bergsagel, DE | 1 |
| Skeel, RT | 1 |
| Holland, E; Johnson, W; Simone, JV | 1 |
| Coccia, PF; Dabich, L; Levine, PH; Roland, A; Stevens, DA | 1 |
| Lampkin, B; Mauer, AM; McWilliams, NB | 1 |
| Schwarz, MI; Tormey, DC; Whitcomb, ME | 1 |
| Komp, DM | 1 |
| Catovsky, D; Das, KC; Hoffbrand, V; Tripp, E | 1 |
| Fass, L; Fefer, A; Mickelson, E; Ochs, HD; Storb, R; Thomas, ED | 1 |
| Gröbe, H; Schellong, G; Schnepper, E | 1 |
| Heilmann, HP; Maas, B | 1 |
| Chaskes, SJ; Solomon, A; Stewart, JA; Vodopick, H | 1 |
| Calabresi, P; Fischer, GA; Lee, SY | 1 |
| Baum, ES; Chapman, KE; Haerr, M; Hays, T; Holton, CP; Hutter, JJ; Mayer, CM; Phillips, LK | 1 |
| Borges, WH; Dyer, A; Hackl, E; Lipp, V; Pierce, M | 1 |
| Bryant, JI; Buckner, CD; Chard, RL; Clift, RA; Epstein, RB; Fefer, A; Fialkow, PJ; Funk, DD; Giblett, ER; Lerner, KG; Neiman, PE; Reynolds, FA; Rudolph, RH; Slichter, S; Storb, R; Thomas, ED | 1 |
| Berard, CW; Carolla, RL; Gralnick, HR; Graw, RG; Gullion, DS; Halterman, RH; Henderson, ES; Herzig, GP; Krueger, GR; Leventhal, BG; Lippman, ME; McGinniss, MH; Merritt, CB; Rogentine, GN; Terasaki, PI; Whang-Peng, J; Yankee, RA | 1 |
| Bryant, JI; Buckner, CD; Clift, RA; Fefer, A; Neiman, P; Ramberg, RE; Storb, R; Thomas, ED | 1 |
| Alsarraf, D; Reese, L | 1 |
| Amiel, JL; Mathé, G; Pouillart, P; Schneider, M; Schwarzenberg, L | 1 |
| Aur, RJ; Hustu, HO; Simone, JV; Verzosa, MS | 2 |
| Chary, KK; Humphrey, GB; Krivit, W; Nesbit, ME | 1 |
| Adams, RA; Flowers, A; Merk, LP; Sundeen, R | 1 |
| Grignani, F; Martelli, MF; Soldani, M; Tonato, M | 1 |
| Aztarain, E; Giralt, M; Raichs, A; Torres, A | 1 |
| Lampkin, BC; Mauer, AM; McWilliams, NB | 2 |
| Colarizi, A; Multari, G; Stegagno, G | 1 |
| Montuori, R; Quattrin, N | 1 |
| Massimo, L | 1 |
| Neville, BG | 1 |
| Schaafsma, S | 1 |
| Harris, RF; Innes, EM; Kay, HE; Knapton, PJ; O'Sullivan, JP; Schwartz, FC; Stuart, J; Thompson, EN; Wells, DG | 1 |
| Aghai, E; Kende, G; Ramot, B; Ravid, M | 1 |
| Aur, RJ; Hustu, HO; Pinkel, D; Simone, J | 2 |
| Ortega, J; Vadakan, VV | 1 |
| Bakkeren, JA; de Vaan, GA; Schretlen, ED | 1 |
| Glidewell, O; Holland, JF | 2 |
| Aghai, E; Kende, G; Ramot, B | 1 |
| Wilmanns, W; Wilms, K | 1 |
| Blom, J; Cooper, T; Ellison, RR; Haurani, F; Holland, JF; Hoogstraten, B; Jacquillat, C; Lee, SL; Leone, LA; Levy, RN; Oberfield, RA; Silver, RT; Ten Pas, A | 1 |
| Pinkel, D | 2 |
| Sinks, LF | 2 |
| Gribetz, I; Leonidas, JC; Robbins, KM; Sanders, M; Strauss, L | 1 |
| Evert, CF; Lampkin, BC; Mauer, AM; McWilliams, NB | 1 |
| Fickers, M; Haak, HL; Speck, B | 1 |
| Dimou, E; Drings, P; Kelleter, R; Kölmel, HW; Manke, HG | 1 |
| Fromer, JL; Jaffe, N | 1 |
| Salvati, A | 1 |
| Bergna, L; Eppinger-Helft, M; Muriel, FS; Pavlovsky, A; Pavlovsky, AA; Pavlovsky, S; Peñalver, J; Suárez, A; Vilaseca, G | 1 |
| Rhomberg, W | 1 |
| Amiel, JL; De Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Pouillart, P; Rappaport, H; Rosenfeld, C; Schneider, M; Schwarzenberg, L; Weiner, R | 1 |
| Halterman, RH; Herberman, RB; Levine, PH; McCoy, JL; Rosenberg, EB; Wunderlich, JR | 1 |
| Duttera, MJ; Geelhoed, GW; Graff, KS; Henderson, ES | 1 |
| Hinkes, E; Plotkin, D | 1 |
| Hughes, WT; Smith, DR | 1 |
| Craddock, CG; Crandall, BF; Hinkes, E; Weber, F | 1 |
| Melhorn, DK; Newman, AJ | 1 |
| Casadei, AM; Del Principe, D; Digilio, G; Iannetti, P; Multari, G | 1 |
| Crist, WM; Ragab, AH; Vietti, TJ | 1 |
| Hardisty, RM; Pushpa, V; Raynsford, G; Till, MM | 1 |
| Vowels, MR; Willoughby, ML | 1 |
| Douglas, ID; Price, LA | 1 |
| Alexander, FW; Delves, HT; Lay, H | 1 |
| Bodey, GP; Coltman, CA; Freireich, EJ; Hart, JS; McCredie, KB; Rodriguez, V; Whitecar, JP | 1 |
| Fritzsche, W; Helbig, W; Kavalle, M; Runge, A; Schneider, D; Schwenke, H; Storch, H; von Baehr, R | 1 |
| Mangalik, A | 1 |
| Armata, J; Cyklis, R; Halikowski, B; Wyszkowski, J | 1 |
| Amiel, JL; Cattan, A; de Vassal, F; Hayat, M; Jasmin, G; Mathe, G; Pouillart, P; Schneider, M; Schwarzenberg, L; Weiner, R | 1 |
| Chisholm, M | 1 |
| Aur, RJ; Hustu, HO; Simone, JV; Verzosa, MS; Wood, A | 1 |
| Aur, RJ; Hustu, HO; Pinkel, D; Simone, JV; Verzosa, MS | 2 |
| Bleyer, WA; Chabner, BA; Drake, JC | 1 |
| Janele, J; Rosa, L | 1 |
| Aspnes, GT; McIntosh, S | 1 |
| McIntosh, S; Pearson, HA | 1 |
| Tay, CH | 1 |
| Bull, JM; Carbone, PP; Duttera, MJ; Henderson, ES; Northup, JD; Stashick, ED | 1 |
| Freeman, JE; Johnston, PG; Voke, JM | 1 |
| Eppinger-Helft, M; Pavlovsky, S; Sackmann Muriel, F | 1 |
| Auclerc, G; Bernard, J; Boiron, M; Bussel, A; Delobel, J; Dresch, C; Flandrin, G; Gemon, MF; Izrael, V; Jacquillat, C; Loisel, JP; Najean, Y; Rain, D; Schaison, G; Seligmann, M; Tanzer, J; Weil, M; Weisgerber, C | 1 |
| Jungi, WF | 1 |
| Wagner, HP | 1 |
| Drings, P; Kölmel, HW; Paal, G | 1 |
| Gjemdal, T; Stavem, P | 2 |
| Simone, J | 1 |
| Gaeta, JF; Halazun, JF; Sinks, LF; Wagner, HR | 1 |
| Glidewell, OJ; Holland, JF | 1 |
| Pinkel, D; Simone, J | 1 |
| Clarkson, B; Gee, T; Haghbin, M; Murphy, ML; Tan, C | 1 |
| Burchenal, JH; Cole, MT; Dowling, MD | 1 |
| Balasheva, II; Osin, AIa; Shifrina, EM; Stepanova, EI | 1 |
| Aghai, E; Bracha, R; Kende, G; Virag, I | 1 |
| Melhorn, DK; Newman, AJ; O'Regan, S | 1 |
| Litwin, J; Stacher, A | 1 |
| Ernst, P | 1 |
| Szalay, GC | 1 |
| Lynch, RG; Tavassoli, FA | 1 |
| Armata, J; Wyszkowski, J | 1 |
| Abbrederis, K; Michlmayr, G; Schmalzl, F | 1 |
| Armata, J; Cyklis, R; Wyszkowski, J | 1 |
| Rokicka-Milewska, R | 1 |
| Burchenal, JH; Clarkson, BD; Haghbin, M; Miké, V; Murphy, ML; Tan, CC | 1 |
| Bleyer, WA; Yancey, ST | 1 |
| Aronson, AS; Garwicz, S; Sörnäs, R | 1 |
| Fridland, A | 1 |
| Mark, LE; Rouhani, J; Sawitsky, A | 1 |
| Armata, J; Depowska, T | 1 |
| Franke, HD; Landbeck, G; Timmermann, J; Winkler, K | 1 |
| Plüss, HJ | 1 |
| Armata, J; Legutko, L; Zajaczkowski, J | 1 |
| Breslow, N; Hammond, D; Karon, M; Miller, DR; Sonley, M | 1 |
| Cebrian Bonesana, A; De Macchi, GH; Eppinger-Helft, M; Hidalgo, G; Pavlovsky, A; Pavlovsky, S; Peñalver, JA; Sackmann Muriel, F | 1 |
| Hansen, NE; Karle, H; Killmann, SA | 1 |
| Tink, A | 1 |
| Pantazopoulos, N; Sinks, LF | 1 |
| O'Gorman Hughes, DW | 1 |
| Andino Pavlovsky, A; Braier, JL; De Sijvarger, SR; Eppinger-Helft, M; Hidalgo, G; Ojeda, FG; Pavlovsky, S; Peñalver, JA; Sackmann Muriel, F | 1 |
| Bertino, JR; Cashmore, AR; Coward, JK; Parameswaran, KN | 1 |
| Aur, RJ; Husto, HO; Pinkel, D; Simone, JV; Verzosa, MS | 1 |
| Borns, PF; Rancier, LF | 1 |
| Crowther, D | 2 |
| Law, IP | 1 |
| Umsawasdi, T | 1 |
| Balikhina, GD; Brilliant, MD; Garbuzov, MI; Meshcheriakova, NA; Vorob'ev, IuI | 1 |
| Furness, ME; Goldie, JH; Price, LA | 1 |
| Connors, TA; Harrap, KR; Jackson, RC; Tattersall, MH | 1 |
| Wrigley, PR | 1 |
| Burchenal, JH; Clarkson, BD; Cunningham, B; Dowling, MD; Gee, TS; Haghbin, M; Tan, CT | 1 |
| Aur, RJ; Borella, L; Green, AA; Pinkel, D; Simone, JV | 1 |
| Lie, SO | 1 |
| Thompson, EN; Williams, R | 1 |
| Péter, A | 2 |
| Dietz, V; Dilger, M; Jacobi, H; Musshoff, K; Sauer, M; Slanina, J; Wehinger, H | 1 |
| Lustman-Marechal, J | 1 |
| Aboul-Enein, MI; Kotb, A; Mohieddin, O | 1 |
| Bricteux, N | 1 |
| Gotoda, E; Hosokawa, M; Imai, T; Takeda, T; Togashi, T | 1 |
| Börzsönyi, M; Görgénui, A; Lapis, K; Machay, T; Schuler, D | 1 |
| Cahalane, S; Fennelly, JJ; Kavanagh, TM; McBride, A; O'Donoghue, S | 1 |
| Borella, L; Green, AA | 1 |
| Bertino, JR; DeConti, RC; Hubbard, S; Marsh, JC; Mitchell, MS; Skeel, RT | 1 |
| Harrap, KR; Tattersall, MH | 1 |
| Muriel, FS | 1 |
| Bishop, A; Foerster, J; Hryniuk, WM | 1 |
| Blatt, PM; Cathey, WJ; Miller, HL; Rothstein, G | 1 |
| Eife, R; Lampert, F; Trowitzsch, L | 1 |
| Atkinson, R; Saiki, JH; Smith, F; Thompson, S | 1 |
| Bernard, J; Jacquillat, C; Weil, M | 1 |
| Pöttgen, W | 1 |
| Bodey, GP; Freireich, EJ; Rodriguez, V | 1 |
| Delalieux, G; Manaster, J; Stryckmans, P | 1 |
| Borella, L; Sen, L | 2 |
| Brilliant, MD | 1 |
| Faĭnshteĭn, FE | 1 |
| Armata, J | 3 |
| Bernard, J | 2 |
| Wilmanns, W | 2 |
| Buckner, CD; Chard, RL; Clift, RA; Fefer, A; Funk, DD; Johnson, FL; Neiman, P; Storb, R; Thomas, ED | 1 |
| Hacker, B; Hall, TC; Kessel, D; Nahas, A | 1 |
| Buckner, CD; Clift, RA; Fefer, A; Lerner, KG; Neiman, PE; Storb, R; Thomas, ED | 1 |
| Andersen, V; Killmann, SA; Weeke, E | 1 |
| Hermann, J; Plenert, W; Zintl, F | 1 |
| Hathaway, FK | 1 |
| Abdulsalam, M; Markum, AH; Muslichan, S; Odang, O; Wahidijat, I | 1 |
| Borella, L; Green, AA; Webster, RG | 1 |
| Breslow, N | 1 |
| Kensler, CJ; Swiniarski, J; Venditti, JM; Wodinsky, I | 1 |
| Bernard, J; Boiron, M; Jacquillat, C; Najean, Y; Thomas, M; Weil, M | 1 |
| Rák, K | 1 |
| Jacquillat, C | 1 |
| Obrecht, P | 2 |
| Amiel, JL; Cattan, A; de Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Rosenfeld, C; Schlumberger, JR; Schneider, M; Schwarzenberg, L | 1 |
| Benckhuijsen, C | 1 |
| Kirchmayer, S | 1 |
| Hill, JM; Hill, NO; Khan, A; Loeb, E; MacLellan, A; Roberts, J; Shields, WF | 1 |
| Dano, K; Nissen, NI | 1 |
| Lorie, IuI | 1 |
| Esposito, L | 1 |
| Cohen, ML; Weiss, EB | 1 |
| Bertino, JR; Chabner, B; Levitt, M; McCullough, JL | 1 |
| Goldin, A | 1 |
| Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS | 1 |
| Block, JB; Carbone, PP; Haskell, CM; Leventhal, BG; Selawry, OS | 1 |
| Paolucci, G; Rosito, P | 1 |
| Fairley, GH | 1 |
| Salen, G; Schumacher, HR | 1 |
| Lindqvist, KJ; Osterland, CK; Ragab, AH | 1 |
| Bernard, J; Boiron, M; Bussel, A; Goguel, A; Goudemand, M; Jacquillat, C; Loisel, JP; Najean, Y; Schaison, G; Seligmann, M; Tanzer, J; Weil, M | 1 |
| Bischof, B | 1 |
| Amiel, JL; de Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Pouillart, P; Rosenfeld, C; Schneider, M; Schwarzenberg, L | 1 |
| Brambilla, G; Caraceni, CE; Cavanna, M; Parodi, S | 1 |
| Ward, JM; Whitlock, RH | 1 |
| Blom, J | 1 |
| Bernard, J; Boiron, M; Levy, JP; Lortholary, P | 1 |
| Kyle, RA; Maldonado, JE | 1 |
| Conklin, JW; Jenkins, VK; Tyndall, RL; Upton, AC; Walburg, HE; Wald, N | 1 |
| Galton, DA | 1 |
| Blom, J; Burgert, EO; Chevalier, L; Denton, R; Glidewell, O; Hananian, J; Holland, JF; Jones, B; Kung, F; Mills, SD; Nyhan, WL; Sheehe, P; Treat, C; Wolman, IJ | 1 |
| Abir, E; Djerassi, I; Farber, S; Neikirk, W | 1 |
| Kauder, E; Mauer, AM; Saunders, EF | 1 |
| Hall, TC; Roberts, D | 2 |
| Huguley, CM; Rundles, RW; Vogler, WR | 1 |
| Kozlowska, J; Rokicka-Milewska, R | 2 |
| Gerhartz, H | 1 |
| Djerassi, I | 1 |
| Henderson, ES | 3 |
| Borella, L; George, P; Hernandez, K; Holton, C; Hustu, O; Pinkel, D | 1 |
| Hall, TC; Kessel, D; Roberts, D | 1 |
| Hardisty, RM; Till, MM | 1 |
| Laurie, HC; Willoughby, ML | 1 |
| Brubaker, C; Hartman, J; Leiken, S; Murphy, ML; Perrin, E; Sitarz, AL; Wolff, JA | 1 |
| Brosseau, C; Rioux, E; St-Arneault, G | 1 |
| Bonatz, KG; Kaltenbach, T; Löffler, H | 1 |
| Lampert, F | 2 |
| Bernard, J; Boiron, M; Jacquillat, C; Najean, Y; Weil, M | 1 |
| Brubaker, CA; Gilchrist, GS; Hammond, D; Hyman, CB; Shore, NA; Williams, KO | 1 |
| Martin, H; Wilmanns, W | 1 |
| Maurice, PA | 1 |
| Minoshima, S | 1 |
| Maher, JF; Rath, CE; Schreiner, GE | 1 |
| Müller, D | 1 |
| Hjort, PF; Stavem, P | 1 |
| Kaita, T; Kawamoto, K; Kimura, T; Okada, H; Otani, T | 1 |
| Pavlovsky, A; Pavlovsky, S | 1 |
| Cartwright, GE; Cathey, WJ; Clarysse, AM; Wintrobe, MM | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Cooper, EH; Gabutti, V; Gavosto, F; Pileri, A; Tarocco, RP | 1 |
| Kajani, MK; Schwartz, IR | 1 |
| Lampkin, BC; Mauer, AM; Nagao, T | 2 |
| Cottafava, F; Fossati-Guglielmoni, A; Massimo, L; Mori, PG; Pelizza, A | 1 |
| Lorie, IuI; Streliukhina, NV | 1 |
| Kanner, SP; Serpick, AA; Walker, MD; Wiernik, PH | 1 |
| Frech, RS; Ragab, AH; Vietti, TJ | 1 |
| Robertson, JH | 1 |
| Armata, J; Cyklis, R; Garapich, M; Garwicz, S; Halikowski, B; Wyszkowski, J | 1 |
| Outeiriño, J; Paniagua, G; Sánchez-Fayos, J; Serrano, J | 1 |
| Fisher, BJ; Gross, S; Melhorn, DK; Newman, AJ | 1 |
| Donaldson, M; Lulenski, G; Newcombe, D | 1 |
| Evans, AE; Gilbert, ES; Zandstra, R | 1 |
| Franco, LG; Teixeira, I | 1 |
| Harmsen, A; Jensen, KB; Reske-Nielsen, E | 1 |
| Ernst, P; Killmann, SA | 1 |
| Delalieux, G; Manaster, J; Socquet, M; Stryckmans, P | 1 |
| Fetterman, GH; Holliday, MA; Rubissow, MJ | 1 |
| Barry, A; Delage, JM | 1 |
| Bots, GT; Schaberg, A; Swaag, EJ | 1 |
| Paolucci, G; Rosito, P; Salvioli, GP | 1 |
| Cathala, B; Jorda, MF; Lareng, L | 1 |
| Cisiano, L; Gabutti, V; Masera, P; Pileri, A; Tarocco, RP | 1 |
| Armata, J; Zajaczkowski, J | 1 |
| Castellari, R; Ferrara, P; Pasquinucci, G | 1 |
| Curci, G; De Pasquale, A; Montero, C; Piccinini, L; Quaglino, D | 1 |
| Auvert, B; Hurel, G; Theron, HP | 1 |
| Bernard, J; Boiron, M; Brunel-Kotschi, R; Bussel, A; Gemon, MF; Jacquillat, C; Larrieu, MJ; Levy, D; Tanzer, J; Weil, M | 1 |
| Boiron, M; Jacquillat, C; Weil, M | 1 |
| Bertino, JR; Capizzi, RL; Cashmore, AR; Johns, DG; Nahas, A | 1 |
| Bastrup-Madsen, P | 1 |
| Cuesta, MB; Gabriel, FD; Kozinn, PJ; Rosener, F; Taschdjian, C | 1 |
| Gerron, GG; Howard, CH; Rudman, D; Vogler, WR | 1 |
| Stacher, A | 1 |
| Henderson, ES; Leventhal, BG | 1 |
| Hüther, W; Rickers, H | 1 |
| Frenkel', MA; Khvatova, NV; Lorie, IuI; Solov'eva, EA | 1 |
| Hardisty, RM; Jones, LH; Kay, HE; Wells, DG | 1 |
| Hirano, M; Koie, K; Morita, A; Sako, F; Uetani, T | 1 |
| Braunsteiner, H; Schmalzl, F | 1 |
| Amromin, GD; Gildenhorn, VB | 1 |
| Hall, TC | 1 |
| Bertino, JR; Capizzi, R; Hryniuk, WM | 1 |
| Armata, J; Wyszkowski, J; Zajaczkowski, J | 1 |
| Bernard, J; Boiron, M; Bussel, A; Dreyfus, B; Jacquillat, C; Larrieu, MJ; Loisel, JP; Rouesse, T; Weil, M | 1 |
| Hellriegel, KP; Möbius, W; Terheggen, HG | 1 |
| de Vaan, GA; Marcar, JR; Schretlen, ED | 1 |
| Amiel, JL; Cattan, A; Mathé, G; Pouillart, P; Schneider, M; Schwarzenberg, L | 1 |
| Hammond, D; Higgins, GR; Lampkin, BC | 1 |
| Einzig, S; Hong, R; Sharp, HL | 1 |
| Freeman, AI; Gaeta, JF; Sinks, LF; Wang, JJ | 1 |
| Gottlieb, JA; Serpick, AA | 1 |
| Schwarzenberg, L | 1 |
| Jacobs, J; Vogler, WR | 1 |
| Loehr, EV; Roberts, D | 1 |
| Blom, J; Burningham, R; Cuttner, J; Falkson, G; Glidewell, O; Holland, JF; Levy, RN; Moon, JH; Onuma, T; Rosner, F; Silver, RT | 1 |
| Bagshawe, KD; Jackson, JG; Rawbone, RG; Shaw, MT | 1 |
| Abir, E; Burgert, EO; Ebaugh, FG; Frei, E; Freireich, EJ; Hananian, J; Holland, JF; Hoogstraten, B; James, GW; Karon, M; Lee, S; Levin, RH; Mills, SD; Moon, JH; Patterson, RB; Sawitsky, A; Selawry, O; Spurr, CL; Taylor, RJ; Wolman, IJ | 1 |
| Blumenthal, G; Greenberg, DM | 1 |
| Botterill, V; Hall, TC; Kessel, D | 1 |
| Taft, LI | 1 |
| Brubaker, C; Hartmann, J; Krivit, W; Murphy, ML; Pierce, M; Thatcher, G | 1 |
| Knisley, RE | 1 |
| Bering, EA; Henderson, ES; Ommaya, AK; Rall, DP; Rubin, RC | 1 |
61 review(s) available for methotrexate and Leukemia, Lymphocytic
| Article | Year |
|---|---|
[T-large granular lymphocyte leukaemia. An important differential diagnosis to Felty's syndrome].
Topics: Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Felty Syndrome; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, T-Cell; Methotrexate; Vidarabine | 2006 |
T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Cyclophosphamide; Cyclosporine; Databases as Topic; Female; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, T-Cell; Male; Methotrexate; Middle Aged; Pentostatin; Retrospective Studies | 2006 |
The pharmacology and clinical use of methotrexate.
Topics: Administration, Oral; Animals; Biological Transport; Central Nervous System; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Amplification; Head and Neck Neoplasms; Humans; Kinetics; Leucovorin; Leukemia, Lymphoid; Lung Neoplasms; Methotrexate; Neoplasms; Osteoma, Osteoid; Thymidylate Synthase; Tissue Distribution | 1983 |
Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer.
Topics: Acute Disease; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Division; Child; Child, Preschool; Clinical Trials as Topic; Hodgkin Disease; Humans; Infant; Kinetics; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Mice; Models, Biological | 1984 |
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin | 1980 |
[Neuroleukemia--prophylaxis and treatment].
Topics: Central Nervous System Diseases; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis | 1982 |
[Acute juvenile lymphoblastic leukemia].
Topics: Asparaginase; Child; Cyclophosphamide; Germany, West; Humans; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Vincristine | 1980 |
Acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Asparaginase; B-Lymphocytes; Bacterial Infections; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisolone; T-Lymphocytes; Testicular Neoplasms; Vincristine | 1982 |
[Prophylactic treatment of meningeal leukemia (author's transl)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Child; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Nitrosourea Compounds; Radiation Injuries; Radiotherapy Dosage | 1981 |
[Prevention of leukemia of the central nervous system. Results of different therapeutic methods and toxic effects].
Topics: Brain; Dexamethasone; Humans; Hypothalamo-Hypophyseal System; Intelligence; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Radiotherapy; Sleep Wake Disorders; Tomography, X-Ray Computed | 1981 |
[Acute complication of intraspinal administration of methotrexate. Report of a case and review of literature].
Topics: Anaphylaxis; Child; Humans; Hypertension; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Pulmonary Edema | 1981 |
[Management of acute juvenile leukemia, with special reference to the studies by a working group in Japan].
Topics: Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate | 1981 |
[Large granular lymphocyte proliferations. Clinical and pathogenic aspects].
Topics: Autoimmune Diseases; Blotting, Southern; Cyclophosphamide; Cytokines; fas Receptor; France; HTLV-I Infections; Humans; Immunophenotyping; Immunosuppressive Agents; Leukemia, Lymphoid; Methotrexate; Neutropenia; Polymerase Chain Reaction; Prognosis; Registries; Splenomegaly | 2001 |
Intrathecal methotrexate overdose without neurotoxicity: case report and literature review.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Nervous System | 1978 |
Acute lymphoblastic leukemia: treatment.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunotherapy; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Prognosis; Recurrence; Remission, Spontaneous; Spinal Cord Neoplasms | 1978 |
[Non-leukemic disease of the central nervous system in children with acute lymphoblastic leukemia. I. Somnolence syndrome (author's transl)].
Topics: Anorexia; Child; Disorders of Excessive Somnolence; Electroencephalography; Headache; Humans; Injections, Spinal; Leukemia, Lymphoid; Mental Disorders; Methotrexate; Myelin Proteins; Neurocognitive Disorders; Time Factors; Vomiting | 1978 |
[Non-leukemic disease of the central nervous system in children with acute lymphoblastic leukemia. II. Methotrexate-induced encephalopathy (author's transl)].
Topics: Autopsy; Brain Diseases; Calcinosis; Cerebellar Diseases; Child; Consciousness; Dysarthria; Electroencephalography; Humans; Leukemia, Lymphoid; Methotrexate; Paralysis; Seizures | 1978 |
The role of radiotherapy in the management of acute lymphocytic leukemia.
Topics: Antineoplastic Agents; Blindness; Brain Neoplasms; Child; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiation Injuries; Spinal Cord Neoplasms | 1978 |
Methotrexate and central nervous system toxicity.
Topics: Biopterins; Brain; Child; Humans; Leukemia, Lymphoid; Methotrexate; Radiation Injuries | 1978 |
Neurotoxicities of current leukemia therapy.
Topics: Antineoplastic Agents; Bone Marrow; Brain Diseases; Central Nervous System Diseases; Child, Preschool; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Nervous System; Radiation Injuries; Radiotherapy; Spinal Puncture | 1979 |
The definitive treatment of children with acute leukemia.
Topics: Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Humans; Immunotherapy; Infections; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms, Multiple Primary; Prednisone; Psychology; Remission, Spontaneous; Vincristine | 1976 |
Anti-folate resistance in leukemia: treatment with "high-dose" methotrexate and citrovorum factor.
Topics: Child; Drug Resistance; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate | 1975 |
Human graft-versus-host disease.
Topics: Bone Marrow Transplantation; Chronic Disease; Graft vs Host Disease; HLA Antigens; Humans; Immunocompetence; Leukemia, Lymphoid; Methotrexate; T-Lymphocytes | 1991 |
Corticosteroid drugs: their role in oncological practice.
Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast Neoplasms; Cyclophosphamide; Dacarbazine; Doxorubicin; Drug Therapy, Combination; Dyspnea; Fluorouracil; Hodgkin Disease; Humans; Hypercalcemia; Leukemia; Leukemia, Lymphoid; Lymphoma; Mechlorethamine; Melphalan; Methotrexate; Multiple Myeloma; Palliative Care; Prednisone; Procarbazine; Receptors, Glucocorticoid; Vinblastine; Vincristine; Vomiting | 1986 |
[Biochemical and clinico-pharmacological aspects of antimetabolites in the treatment of leukemia].
Topics: Child; Drug Synergism; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate | 1988 |
Long-term sequelae of cancer treatment on the central nervous system in childhood.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy; Risk Factors | 1987 |
[Methotrexate in pediatric hemato-oncology].
Topics: Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Nervous System Diseases; Osteosarcoma | 1987 |
New aspects of clinical and cellular pharmacodynamics of methotrexate with special emphasis on its role in the treatment of acute lymphoblastic leukemia in children.
Topics: Age Factors; Cell Membrane; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Carriers; Humans; Infant; Leukemia, Lymphoid; Methotrexate | 1987 |
Treatment-related leukoencephalopathy. A study of three cases and literature review.
Topics: Adolescent; Adult; Antineoplastic Agents; Bone Neoplasms; Brain; Brain Diseases; Brain Neoplasms; Cytarabine; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 1986 |
Chemotherapy of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Patient Compliance; Prednisone; Vincristine | 1986 |
Treatment of acute lymphoid leukemia in children: current regimens and future prospects.
Topics: Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Mice; Prognosis; Recurrence; T-Lymphocytes | 1986 |
Indications for and benefits of intensive therapies in treatment of childhood cancers.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Etoposide; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Risk; Sarcoma, Ewing | 1986 |
Treatment of acute lymphoblastic leukemia.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Cytopathogenic Effect, Viral; Daunorubicin; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Meninges; Mercaptopurine; Methotrexate; Mice; Oncogenic Viruses; Patient Care Team; Remission, Spontaneous; Reverse Transcriptase Inhibitors; RNA Viruses; RNA-Directed DNA Polymerase; Time Factors; Vincristine | 1972 |
Drug-induced lung disease.
Topics: Anti-Bacterial Agents; Anticoagulants; Antihypertensive Agents; Bleomycin; Busulfan; Chlorpropamide; Cyclophosphamide; Hemorrhage; Heroin; Humans; Hydrochlorothiazide; Hypertension, Pulmonary; Inhalation; Leukemia, Lymphoid; Lipids; Lung; Lung Diseases; Methotrexate; Methysergide; Nitrofurantoin; Phenytoin; Pulmonary Edema | 1973 |
Management of childhood leukemia.
Topics: Alkanesulfonates; Amidines; Bone Marrow Examination; Chickenpox; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; gamma-Globulins; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Nervous System Diseases; Phenyl Ethers; Physician-Patient Relations; Pneumonia, Pneumocystis; Prednisone; Pseudomonas Infections; Recurrence; Testicular Neoplasms; Vincristine | 1974 |
Bone marrow transplantation-clinical results and problems.
Topics: Agammaglobulinemia; Anemia, Aplastic; Animals; Antilymphocyte Serum; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Transplantation; Cyclophosphamide; Graft vs Host Reaction; Histocompatibility Antigens; Histocompatibility Testing; Humans; Immunologic Deficiency Syndromes; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methotrexate; Mosaicism; Prognosis; Rabbits; Sepsis; Tissue Donors; Transplantation, Homologous | 1973 |
Marrow transplants in aplastic anemia and leukemia.
Topics: Anemia, Aplastic; Animals; Blood Platelets; Blood Transfusion; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Dogs; Female; Genotype; Graft vs Host Reaction; Histocompatibility Testing; Humans; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Patient Isolators; Pregnancy; Radiation Chimera; Transplantation Immunology; Transplantation, Homologous; Twins | 1974 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Leukemia, Lymphoid; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Nitrogen Mustard Compounds; Prednisone; Pregnancy; Time Factors; Trophoblastic Neoplasms; Vinblastine | 1971 |
Treatment of acute leukemia.
Topics: Asparaginase; Bacterial Infections; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Hemorrhage; Humans; Immunotherapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mitosis; Neoplasms, Nerve Tissue; Prednisone; Remission, Spontaneous; Testicular Neoplasms; Uric Acid; Vincristine | 1972 |
Paraplegia following intrathecal chemotherapy.
Topics: Adolescent; Alcohols; Autopsy; Benzyl Compounds; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Male; Methotrexate; Parabens; Paraplegia; Pharmaceutic Aids; Spinal Nerve Roots; Time Factors | 1972 |
[Progress in the chemotherapy of acute leukemias].
Topics: Adult; Age Factors; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Follow-Up Studies; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Vincristine | 1972 |
Combination chemotherapy for lymphomas and leukemias.
Topics: Adult; Burkitt Lymphoma; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Combinations; Hodgkin Disease; Humans; Immunotherapy; Infections; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Mercaptopurine; Methotrexate; Middle Aged; Nitrogen Mustard Compounds; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Vincristine | 1973 |
[Treatment of acute leukemia. Controlled clinical trials and experimental data with a view to a more rational administration of anti-leukemic drugs].
Topics: Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisolone; Vincristine | 1973 |
[Treatment of acute leukemias].
Topics: Acute Disease; Adult; Age Factors; Antineoplastic Agents; Asparaginase; Child; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methods; Methotrexate; Prednisolone; Recurrence; Remission, Spontaneous; Vincristine | 1973 |
[Clinical aspects of the problem of treating leukemias].
Topics: Acute Disease; Antineoplastic Agents; Chlorambucil; Chlorine; Chronic Disease; Daunorubicin; Dimethoate; Drug Therapy, Combination; Ethylamines; Glucocorticoids; Humans; Immunoglobulins; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Lymphocytosis; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous | 1973 |
[Danger of hyperuricemia in the treatment of acute leukemia, lymphosarcoma and reticulosarcoma].
Topics: Acute Disease; Allopurinol; Antineoplastic Agents; Child; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Prednisone; Uric Acid; Xanthine Oxidase | 1974 |
Present treatment of acute leukemias.
Topics: Asparaginase; Blood Transfusion; Cytarabine; Daunorubicin; Humans; Immunotherapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Meninges; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous | 1973 |
[Current status of cytostatic therapy].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mitosis; Neoplasm Metastasis; Thymine Nucleotides | 1974 |
[Diagnosis and therapy of acute lymphatic leukemia in childhood].
Topics: Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Humans; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisolone; Remission, Spontaneous; Testicular Neoplasms; Time Factors; Vincristine | 1974 |
[Current possibilities and trends in the treatment of acute leukemia].
Topics: Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1968 |
[Treatment of acute leukemias].
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Prednisone; Vincristine | 1968 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine | 1969 |
[Present status and perspectives in the development of the treatment of acute leukemias].
Topics: Antineoplastic Agents; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone; Vincristine | 1969 |
[New principles of treatment in acute leukemia].
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Female; Guanidines; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitroso Compounds; Prednisone; Thrombocytopenia; Urea; Uric Acid; Vincristine | 1970 |
[Treatment of acute leukosis].
Topics: Acute Disease; Adrenal Cortex Hormones; Antineoplastic Agents; Asparaginase; Blood Transfusion; Cyclophosphamide; Diagnosis, Differential; Humans; Immunization; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisolone; Vincristine | 1970 |
Therapeutic management of remissions in acute lymphoblastic leukemia in children.
Topics: Administration, Oral; Age Factors; Animals; Bone Marrow Examination; Child; Drug Synergism; Humans; Injections, Intramuscular; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mice; Myelography; Prognosis; Time Factors | 1970 |
[On the use of daunomycin in acute leukemias in childhood].
Topics: Blood Cell Count; Blood Cells; Blood Transfusion; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone | 1969 |
New approaches to chemotherapy with folate antagonists: use of leucovorin "rescue" and enzymic folate depletion.
Topics: Adult; Animals; Carboxypeptidases; Carcinoma 256, Walker; Carcinoma, Squamous Cell; Deoxyuridine; Diet; Drug Combinations; Drug Synergism; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Mice; Rats; Tritium | 1971 |
Combination chemotherapy with folate antagonists.
Topics: Adult; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Child; Drug Combinations; Drug Interactions; Drug Synergism; Folic Acid Antagonists; Humans; Injections, Subcutaneous; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Mice; Mice, Inbred Strains; Nitrogen Mustard Compounds; Prednisone; Time Factors | 1971 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
Combination chemotherapy in malignant diseases.
Topics: Adult; Antineoplastic Agents; Asparaginase; Carmustine; Child; Cyclophosphamide; Cytarabine; Cytosine; Daunorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Immunotherapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Nitrogen Mustard Compounds; Prednisolone; Prednisone; Procarbazine; Remission, Spontaneous; Vincristine | 1971 |
120 trial(s) available for methotrexate and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Phase I study of dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) chemotherapy for advanced-stage, relapsed or refractory extranodal natural killer (NK)/T-cell lymphoma and leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Etoposide; Humans; Ifosfamide; Leukemia, Lymphoid; Lymphoma, Extranodal NK-T-Cell; Methotrexate; Middle Aged; Recurrence | 2008 |
Presymptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukaemia: comparison of 1800 rad and 2400 rad. A report for Children's Cancer Study Group.
Topics: Brain Neoplasms; Central Nervous System; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy Dosage; Random Allocation; Spinal Cord Neoplasms | 1981 |
Effect of isolated central nervous system leukaemia on bone marrow remission and survival in childhood acute lymphoblastic leukaemia. A report for Children's Cancer Study Group.
Topics: Adolescent; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy, High-Energy; Random Allocation; Remission, Spontaneous; Risk; Spinal Cord Diseases | 1981 |
Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia.
Topics: Bone Marrow Examination; Central Nervous System Diseases; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Probability; Random Allocation; Recurrence; Testicular Neoplasms | 1984 |
Serial cranial computed-tomography scans in children with leukemia given two different forms of central nervous system therapy.
Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Myelin Basic Protein; Tomography, X-Ray Computed | 1983 |
Prognostic factors and therapy in acute lymphoblastic leukemia of childhood: CCG-141. A report from childrens cancer study group.
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Prednisone; Probability; Prognosis; Random Allocation; Testicular Neoplasms; Vincristine | 1983 |
Results of LSA2-L2 therapy in children with high-risk acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Topics: Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Follow-Up Studies; Gold Radioisotopes; Humans; Leukemia, Lymphoid; Lymphoma; Methotrexate; Risk | 1983 |
[High-dosage intralumbar methotrexate administration. A report on clinical experience].
Topics: Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Lumbosacral Region; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local | 1983 |
Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Doxorubicin; Follow-Up Studies; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prednisone; Risk; Vincristine | 1983 |
Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen.
Topics: Acute Disease; Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Drug Administration Schedule; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Random Allocation; Spinal Cord Neoplasms; Time Factors | 1983 |
Reduced lung function in leukaemia patients undergoing bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cyclosporins; Graft vs Host Reaction; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lung; Lung Volume Measurements; Methotrexate; Pulmonary Diffusing Capacity; Pulmonary Ventilation; Whole-Body Irradiation | 1984 |
Acute leukemia in children. Model for the development of scientific methodology for clinical therapeutic research in cancer.
Topics: Acute Disease; Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Division; Child; Child, Preschool; Clinical Trials as Topic; Hodgkin Disease; Humans; Infant; Kinetics; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Mice; Models, Biological | 1984 |
[Treatment of acute childhood leukemia. A new protocol 811 for the standard risk group of acute lymphocytic leukemia (Phase III study)].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Vincristine | 1983 |
Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B.
Topics: Adult; Antibiotics, Antineoplastic; Asparaginase; B-Lymphocytes; Brain Neoplasms; Clinical Trials as Topic; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Naphthacenes; Neutropenia; Prednisone; Prognosis; Prospective Studies; Random Allocation; T-Lymphocytes; Thrombocytopenia; Vincristine | 1984 |
Impact of treatment efficacy on the prognostic value of glucocorticoid receptor levels in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis; Receptors, Glucocorticoid; Receptors, Steroid | 1984 |
[Evaluation of two methods of maintenance chemotherapy with methotrexate and 6-mercaptopurine for childhood acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Random Allocation; Vincristine | 1984 |
[Methotrexate levels in the blood and cerebrospinal fluid in children with acute lymphoid leukemia treated with medium doses of methotrexate].
Topics: Child, Preschool; Clinical Enzyme Tests; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Methotrexate | 1984 |
[Treatment of acute childhood leukemia. A new protocol 811 for the high risk group of acute lymphocytic leukemia (Phase III study)].
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Doxorubicin; Humans; Infant; Leukemia; Leukemia, Lymphoid; Methotrexate; Vincristine | 1984 |
Comparison of intermediate-dose methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children.
Topics: Adolescent; Adult; Brain; Central Nervous System Diseases; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy Dosage; Random Allocation; Time Factors | 1983 |
Comparison of central nervous system prophylaxis with cranial radiation and intrathecal methotrexate versus intrathecal methotrexate alone in acute lymphoblastic leukemia.
Topics: Adult; Brain; Brain Neoplasms; Child; Dexamethasone; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Psychomotor Performance; Tomography, X-Ray Computed | 1983 |
Comparison of chemotherapy with immunotherapy for maintenance of acute lymphoblastic leukemia in children and adults.
Topics: Adolescent; Adult; Asparaginase; BCG Vaccine; Carmustine; Child; Child, Preschool; Cyclophosphamide; Humans; Immunotherapy; Infant; Injections, Spinal; Leukemia, Lymphoid; Lymphocyte Transfusion; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1983 |
Factors associated with IQ scores in long-term survivors of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Infant; Intelligence; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy Dosage; Sex Factors; Wechsler Scales | 1984 |
Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia.
Topics: Adolescent; Age Factors; Behavior; Brain; Child; Child, Preschool; Cognition; Combined Modality Therapy; Female; Humans; Intelligence; Leukemia, Lymphoid; Male; Methotrexate; Radiation Injuries; Sex Factors; Time Factors | 1984 |
Results of a multicentre study of the treatment of acute lymphoblastic leukaemia in adolescents and adults (1978-1981).
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Cytarabine; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1982 |
[Clinical effectiveness and immunological control of the immunochemotherapy of acute leukemia in children using a Corynebacterium parvum preparation].
Topics: Adjuvants, Immunologic; Blood Proteins; Child; Child, Preschool; Clinical Trials as Topic; Complement System Proteins; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunoglobulins; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Propionibacterium acnes; Time Factors | 1982 |
The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemia.
Topics: Adolescent; Child; Child, Preschool; Cytarabine; Humans; Infant; Injections, Spinal; Intelligence; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Wechsler Scales | 1981 |
[All 77-01 therapy study for treatment of acute lymphocytic leukemia in childhood (author's transl)].
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1981 |
Adjuvant specific immunotherapy in maintenance treatment of adult acute non-lymphocytic leukemia.
Topics: Adolescent; Adult; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Immunotherapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Thioguanine; Vincristine | 1981 |
Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: a pediatric oncology group study.
Topics: Adolescent; Age Factors; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Neoplasm Staging; Prednisone; Prognosis; Vincristine | 1982 |
[Prophylactic CNS therapy in childhood leukemia--randomized controlled study of high-dose intravenous methotrexate and cranial irradiation].
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Leukemia, Lymphoid; Male; Methotrexate | 1982 |
Modified LSA2-L2 treatment in 53 children with E-rosette-positive T-cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study).
Topics: Adolescent; Allopurinol; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carmustine; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Prognosis; Rosette Formation; T-Lymphocytes; Thioguanine; Vincristine | 1982 |
Comparison of prednisolone, vincristine, methotrexate and 6-mercaptopurine vs. 6-mercaptopurine and prednisone maintenance therapy in childhood acute leukemia: a Southwest Oncology Group Study.
Topics: Age Factors; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Probability; Prognosis; Vincristine | 1980 |
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Clinical Trials as Topic; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Vincristine | 1982 |
Sanctuary therapy: a randomized trial of 724 children with previously untreated acute lymphoblastic leukemia: A Report from Children's Cancer Study Group.
Topics: Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Nervous System Neoplasms; Prognosis; Radiotherapy Dosage; Random Allocation; Testicular Neoplasms | 1982 |
Asparaginase-methotrexate in combination chemotherapy: schedule-dependent differential effects on normal versus neoplastic cells.
Topics: Adult; Animals; Asparaginase; Cells, Cultured; Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia L5178; Leukemia, Lymphoid; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors | 1981 |
Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate.
Topics: Administration, Oral; Adult; Aged; Communicable Diseases; Dose-Response Relationship, Drug; Female; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Humans; Immunophenotyping; Leukemia, Lymphoid; Lymphocyte Count; Male; Methotrexate; Middle Aged; Neutrophils; Prospective Studies | 1994 |
Evaluation of intensification and maintenance programs in the treatment of acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Radiotherapy, High-Energy; Remission, Spontaneous; Risk; Time Factors; Vincristine | 1978 |
High dose methotrexate in acute lymphocytic leukemia in childhood.
Topics: Asparaginase; Child; Clinical Trials as Topic; Dexamethasone; Drug Eruptions; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Infant; Leucovorin; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Stevens-Johnson Syndrome; Stomatitis; Vincristine | 1978 |
Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy.
Topics: Adolescent; Brain; Child; Child, Preschool; Cytarabine; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Tomography, X-Ray Computed | 1978 |
Results of the therapy of acute leukemia. A cooperative trial by the Italian Association Against Leukemias.
Topics: Adolescent; Adult; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1978 |
Combination chemotherapy and radiotherapy for acute lymphocytic leukemia in adults: results of CALGB protocol 7113.
Topics: Adult; Asparaginase; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisone; Prognosis; Vincristine | 1979 |
The value of maintenance therapy following treatment of central nervous system leukemia.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Brain Neoplasms; Child; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Recurrence; Remission, Spontaneous; Retrospective Studies; Spinal Cord Neoplasms; Time Factors | 1977 |
Results in children of acute lymphoid leukemia: protocol ICIG-ALL 9 consisting of chemotherapy for only 9 months followed by active immunotherapy: comparison with the results of more prolonged chemotherapy protocols. Recognition of two groups of acute lym
Topics: Adolescent; Antineoplastic Agents; Asparaginase; BCG Vaccine; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Humans; Immunotherapy; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Vincristine | 1977 |
High-dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia.
Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate; Middle Aged; Remission, Spontaneous; Time Factors; Vincristine | 1978 |
Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Humans; Infusions, Parenteral; Kinetics; Leucovorin; Leukemia, Lymphoid; Methotrexate; Osteosarcoma; Time Factors | 1978 |
Baker's antifol in children with late-stage acute lymphocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia, Lymphoid; Methotrexate; Mouth Mucosa; Skin; Triazines | 1978 |
Prophylactic CNS therapy in childhood acute leukemia: review of methods used.
Topics: Antineoplastic Agents; Catheters, Indwelling; Central Nervous System; Central Nervous System Diseases; Child; Clinical Trials as Topic; Cytarabine; Drug Therapy, Combination; Humans; Hydrocortisone; Injections, Intraventricular; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Radiotherapy; Radiotherapy Dosage; Time Factors | 1979 |
Treatment of overt meningeal leukaemia in children: results of second MRC meningeal leukaemia trial.
Topics: Brain; Cerebrospinal Fluid; Child; Humans; Leukemia, Lymphoid; Leukocyte Count; Meninges; Methotrexate; Radiotherapy, High-Energy; Recurrence; Spinal Cord | 1976 |
Combined modality therapy of acute lymphocytic leukemia.
Topics: Age Factors; Antineoplastic Agents; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Radiotherapy; Remission, Spontaneous; Spinal Cord Neoplasms; Vincristine | 1975 |
Effects of central-nervous-system irradiation on neuropsychologic functioning of children with acute lymphocytic leukemia.
Topics: Adolescent; Bender-Gestalt Test; Central Nervous System; Child; Child Development; Child, Preschool; Educational Measurement; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Motor Skills; Prospective Studies; Psychological Tests; Radiation Effects; Radiotherapy; Remission, Spontaneous; Retrospective Studies; Stanford-Binet Test; Visual Perception; Wechsler Scales | 1975 |
BCG in the treatment of acute lymphocytic leukemia.
Topics: Adolescent; BCG Vaccine; Child; Child, Preschool; Humans; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy.
Topics: Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Neutropenia; Neutrophils; Remission, Spontaneous; Time Factors | 1976 |
The role of irradiation in central nervous system treatment and prophylaxis for acute lymphoblastic leukemia.
Topics: Adolescent; Central Nervous System; Child; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate | 1976 |
Remission maintenance therapy for meningeal leukaemia: intrathecal methotrexate and dexamethasone versus intrathecal craniospinal irradiation with a radiocolloid.
Topics: Adolescent; Adult; Child; Child, Preschool; Colloids; Dexamethasone; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Phosphorus Radioisotopes; Remission, Spontaneous; Time Factors | 1976 |
The current status of the treatment of childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Age Factors; Animals; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1976 |
Cell kinetics in leukemia. Correlation with clinical features and response to chemotherapy.
Topics: Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; DNA, Neoplasm; Drug Therapy, Combination; Humans; Kinetics; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Mitotic Index; Thioguanine | 1975 |
Intensity of immunosuppressive therapy and the incidence of Pneumocystis carinii pneumonitis.
Topics: Antineoplastic Agents; Asparaginase; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pneumonia, Pneumocystis; Prednisone; Vincristine | 1975 |
An attempt at synchronization of marrow cells in acute leukemia: relationship to therapeutic response.
Topics: Adult; Age Factors; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; Female; Humans; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate; Middle Aged; Remission, Spontaneous; Sex Factors; Vincristine | 1976 |
Analysis of treatment in childhood leukaemia. I. Predisposition to methotrexate-induced neutropenia after craniospinal irradiation. Report to the Medical Research Council of the Working Party on Leukaemia in Childhood.
Topics: Agranulocytosis; Central Nervous System; Child; Child, Preschool; Clinical Trials as Topic; Cytarabine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphocytes; Mercaptopurine; Methotrexate; Neutropenia; Prednisolone; Radiation Effects; Radiotherapy Dosage; Remission, Spontaneous; Time Factors; Vincristine | 1975 |
[Acute lymphatic leukemia in children in the Netherlands; study ALL I, 1972-1973; Dutch Childhood Leukemia Study Group].
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Netherlands; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Biopterin and neurotransmitter amine metabolism in children with acute lymphoblastic leukemia receiving methotrexate therapy.
Topics: Adolescent; Biopterins; Child; Child, Preschool; Clinical Trials as Topic; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Neurotransmitter Agents; Pteridines | 1986 |
Prospective study of central nervous system changes in children with acute lymphoblastic leukemia receiving two different methods of central nervous system prophylaxis.
Topics: Adolescent; Asparaginase; Central Nervous System; Child; Clinical Trials as Topic; Electroencephalography; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Myelin Basic Protein; Prednisone; Prospective Studies; Random Allocation; Vincristine | 1986 |
Prognostic importance of myelosuppression during maintenance treatment of lymphoblastic leukaemia. Leukaemia in Childhood Working Party of the Medical Research Council.
Topics: Adolescent; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutropenia; Prognosis; Randomized Controlled Trials as Topic; Survival Rate; United Kingdom | 1989 |
Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL trials, 1972-84. Report to the Council by the Working Party on Leukaemia in Childhood.
Topics: Administration, Oral; Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Drug Combinations; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Injections, Intramuscular; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1986 |
Treatment of standard- and high-risk childhood acute lymphoblastic leukaemia with two CNS prophylaxis regimens.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy, High-Energy; Remission Induction; Risk; Time Factors | 1987 |
Comparison of intermittent or continuous methotrexate plus 6-mercaptopurine in regimens for standard-risk acute lymphoblastic leukemia in childhood (JCCLSG-S811). The Japanese Children's Cancer and Leukemia Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Nervous System Neoplasms; Prednisone; Random Allocation; Remission Induction; Time Factors; Vincristine; Vindesine | 1988 |
Efficacy of high-dose methotrexate in childhood acute lymphocytic leukemia: analysis by contemporary risk classifications.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Drug Administration Schedule; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Methotrexate; Random Allocation; Retrospective Studies; Risk Factors | 1988 |
Therapy for adolescent and adult acute lymphoblastic leukemia: randomization of induction and consolidation therapies (preliminary results of EORTC Study 58791).
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Doxorubicin; Europe; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Prognosis; Random Allocation; Remission Induction; Thioguanine; Vincristine | 1987 |
Intermediate-risk childhood acute lymphoblastic leukemias: amsacrine + cytosine arabinoside versus intermediate-dose methotrexate for consolidation, and 6-mercaptopurine + methotrexate + vincristine versus monthly pulses for maintenance.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Cytarabine; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Random Allocation; Risk; Vincristine | 1987 |
Treatment of acute lymphoblastic leukemia in children with the BFM protocol: a cooperative study and analysis of prognostic factors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Belgium; Child; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Doxorubicin; France; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Prognosis; Remission Induction; Risk; Thioguanine; Vincristine | 1987 |
Results of acute lymphoblastic leukemia therapy in childhood with a modified BFM protocol in a multicenter study in the German Democratic Republic.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Germany, East; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Prednisone; Random Allocation; Remission Induction; Risk; Thioguanine; Vincristine | 1987 |
Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL).
Topics: Central Nervous System; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Humans; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Random Allocation | 1987 |
Long-term evaluation of a CNS prophylaxis trial--treatment comparisons and outcome after CNS relapse in childhood ALL: a report from the Childrens Cancer Study Group.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Clinical Trials as Topic; Humans; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Random Allocation; Spinal Cord Neoplasms | 1987 |
Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia.
Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Injections, Intramuscular; Leukemia, Lymphoid; Male; Methotrexate; Random Allocation; Sex Factors; Time Factors | 1987 |
[Treatment of childhood acute lymphoblastic leukemia: efficacy of intermittent pulses of 6-mercaptopurine and methotrexate for maintenance chemotherapy, CCLSG-S811 (phase III study). Children's Cancer and Leukemia Study Group].
Topics: Administration, Oral; Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Injections, Intravenous; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Remission Induction | 1987 |
Treatment of acute lymphoblastic leukemia in children with the BFM protocol. A cooperative pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Female; Hemoglobins; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Prognosis; Thioguanine; Vincristine | 1987 |
Memory function in disease-free survivors of childhood acute lymphocytic leukemia given CNS prophylaxis with or without 1,800 cGy cranial irradiation.
Topics: Child; Humans; Leukemia, Lymphoid; Memory Disorders; Methotrexate; Nervous System Neoplasms; Neuropsychological Tests; Radiotherapy | 1988 |
Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect.
Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Flow Cytometry; Hemoglobins; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Leukocyte Count; Male; Metabolic Clearance Rate; Methotrexate; Prospective Studies; Random Allocation; Recurrence | 1986 |
Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infections; Injections, Intramuscular; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Prospective Studies; Random Allocation | 1987 |
Methotrexate bioavailability after oral and intramuscular administration in children.
Topics: Administration, Oral; Biological Availability; Child; Female; Humans; Injections, Intramuscular; Kinetics; Leukemia, Lymphoid; Methotrexate | 1987 |
Transient acute hepatotoxicity of high-dose methotrexate therapy during childhood.
Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Time Factors | 1987 |
Clinical pharmacodynamic studies of high-dose methotrexate in acute lymphocytic leukemia.
Topics: Child; Child, Preschool; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Leukemia, Lymphoid; Metabolic Clearance Rate; Methotrexate | 1987 |
Cytosine arabinoside/cyclophosphamide pulses during continuation therapy for childhood acute lymphoblastic leukemia. Potential selective effect in T-cell leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Cytarabine; Drug Evaluation; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Random Allocation; T-Lymphocytes; Vincristine | 1987 |
Lymphoblastic lymphoma in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Prednisone; Prognosis; Thioguanine; Vincristine | 1986 |
[Acute lymphoblastic leukemia in children. Long survivals obtained with protocols C2-72 and D-74 (1972-1977)].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; BCG Vaccine; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Immunotherapy; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisolone; Random Allocation; Testicular Neoplasms; Vincristine | 1986 |
Use of the automatic interaction detector method to identify patient characteristics related to methotrexate clearance.
Topics: Adolescent; Alanine Transaminase; Child; Child, Preschool; Clinical Trials as Topic; Computers; Creatinine; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Male; Metabolic Clearance Rate; Methotrexate; Prognosis; Prospective Studies; Random Allocation; Sex Factors | 1986 |
Improved disease-free survival of children with acute lymphoblastic leukemia at high risk for early relapse with the New York regimen--a new intensive therapy protocol: a report from the Childrens Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Prognosis; Radiotherapy Dosage; Recurrence; Risk; Thioguanine; Time Factors; Vincristine | 1986 |
Intermediate dose methotrexate in childhood acute lymphoblastic leukemia resulting in decreased incidence of testicular relapse.
Topics: Actuarial Analysis; Acute Disease; Child; Child, Preschool; Clinical Trials as Topic; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Nervous System Neoplasms; Random Allocation; Risk; Testicular Neoplasms | 1986 |
Intermediate-dose methotrexate in the treatment of childhood acute lymphocytic leukaemia: lack of benefit during maintenance therapy following intensive induction therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prednisone; Prognosis; Random Allocation; Vincristine | 1986 |
Medical Research Council leukaemia trial--UKALL V: an attempt to reduce the immunosuppressive effects of therapy in childhood acute lymphoblastic leukemia. Report to the Council by the Working Party on Leukaemia in Childhood.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; England; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Random Allocation; Vincristine | 1986 |
The enigma of testicular leukemia: a critical review.
Topics: Animals; Bone Marrow Diseases; Clinical Trials as Topic; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Prognosis; Rats; Research Design; Sex Factors; Testicular Neoplasms | 1986 |
Comparison of maintenance treatment regimens for first central nervous system relapse in children with acute lymphocytic leukemia. A Pediatric Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Follow-Up Studies; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Radiotherapy Dosage; Time Factors | 1985 |
Computerized tomography scan findings in children with acute lymphocytic leukemia treated with three different methods of central nervous system prophylaxis.
Topics: Brain Neoplasms; Child; Combined Modality Therapy; Drug Administration Schedule; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Random Allocation; Tomography, X-Ray Computed | 1985 |
[Cooperative studies in the treatment of acute lymphoblastic leukemia in children in Austria--report of 10 years' experience].
Topics: Asparaginase; Austria; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Risk; Vincristine | 1985 |
The importance of an isolated central nervous system relapse in children with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Nervous System Neoplasms; Prognosis; Radiotherapy Dosage | 1985 |
Medical Research Council leukaemia trial, UKALL VII. A report to the Council by the Working Party on Leukaemia in Childhood.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Clinical Trials as Topic; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Methotrexate; Random Allocation | 1985 |
Intermediate dose methotrexate (IDM) in children with acute lymphocytic leukemia (ALL). An update.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine | 1985 |
Acute lymphocytic leukemia in children: maintenance therapy with methotrexat administered intermittently. Acute Leukemia Group B.
Topics: Adolescent; Adult; Blood Platelets; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Dyspnea; Female; Gastrointestinal Diseases; Hemoglobins; Herpesviridae Infections; Humans; Infant; Infant, Newborn; Infections; Injections, Intramuscular; Leukemia, Lymphoid; Leukocyte Count; Leukopenia; Male; Methotrexate; Mouth Diseases; Neurologic Manifestations; Osteoporosis; Pneumonia; Pneumonia, Pneumocystis; Prednisolone; Respiratory Tract Diseases; Thrombocytopenia; Vincristine | 1969 |
A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia.
Topics: Adolescent; Adult; Blood Transfusion, Autologous; Brain Neoplasms; Child; Child, Preschool; Cobalt Isotopes; Cyclophosphamide; Female; Humans; Infant; Infections; Injections, Intravenous; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Radiation Dosage; Radiation Effects; Remission, Spontaneous; Spinal Cord Neoplasms; Time Factors | 1972 |
Oncologists' reply: survival expectancy in acute lymphocytic leukemia.
Topics: Adult; Canada; Child; Denmark; France; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; South Africa; Switzerland; United States; Vincristine | 1972 |
Chemotherapy of acute lymphocytic leukemia of childhood.
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Carmustine; Cell Division; Cell Transformation, Neoplastic; Child; Child, Preschool; Daunorubicin; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mitosis; Prednisone; Remission, Spontaneous; Vincristine | 1972 |
Comparison of two methods of preventing central nervous system leukemia.
Topics: Adolescent; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cobalt Isotopes; Cyclophosphamide; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Recurrence; Vincristine | 1973 |
Prevention of central nervous system leukemia by irradiation.
Topics: Brain; Cell Count; Central Nervous System; Central Nervous System Diseases; Child; Cytodiagnosis; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Methotrexate; Radiation Effects; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous; Spinal Cord | 1973 |
Acute lymphocytic leukemia in childhood.
Topics: Asparaginase; Black People; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosuppression Therapy; Infections; Injections, Spinal; Leukemia, Lymphoid; Leukopenia; Male; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
Clinical trials of the acute leukemia group B in acute lymphocytic leukemia of childhood.
Topics: Adolescent; Asparaginase; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1973 |
Combination chemotherapy of acute leukaemia in adults. Comparison of two schedules.
Topics: Administration, Oral; Adult; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis | 1974 |
Cessation of therapy during complete remission of childhood acute lymphocytic leukemia.
Topics: Central Nervous System; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Leukocyte Count; Liver; Male; Meninges; Methotrexate; Remission, Spontaneous; Spleen; Time Factors | 1974 |
Treatment of acute lymphoblastic leukaemia: effect of "prophylactic" therapy against central nervous system leukaemia. Report ot the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood.
Topics: Adolescent; Blood Cell Count; Blood Platelets; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Radiotherapy Dosage; Remission, Spontaneous; Time Factors | 1973 |
[Treatment of acute leukemia. Controlled clinical trials and experimental data with a view to a more rational administration of anti-leukemic drugs].
Topics: Clinical Trials as Topic; Cytarabine; Daunorubicin; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisolone; Vincristine | 1973 |
Extracorporeal irradiation of the blood: clinical applications.
Topics: Blood Cells; Cesium Isotopes; Clinical Trials as Topic; Cobalt Radioisotopes; Cytidine; Erythrocytes; Extracorporeal Circulation; Hematocrit; Humans; Immunosuppression Therapy; Isotope Labeling; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Methotrexate; Radiation Effects; Radioisotope Teletherapy; Radioisotopes; Radiotherapy Dosage; Reticulocytes; Strontium Radioisotopes; Thymidine; Tritium; Yttrium Isotopes | 1974 |
The role played by radiotherapy in the UKALL III series of trials for the treatment of acute lymphoblastic leukaemia in childhood.
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Cytarabine; Drug Therapy, Combination; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Posture; Prednisolone; Radiotherapy Dosage; Vincristine | 1974 |
Response to highly purified L-asparaginase during therapy of acute leukemia.
Topics: Adolescent; Adult; Asparaginase; Carbon Isotopes; Child; Child, Preschool; Clinical Trials as Topic; Female; Hematopoiesis; Humans; Injections, Intravenous; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Valine | 1969 |
Treatment of acute lymphoblastic leukaemia. Comparison of immunotherapy (B.C.G.), intermittent methotrexate, and no therapy after a five-month intensive cytotoxic regimen ((Concord trial). Preliminary report to the Medical Research Council by the Leukaemi
Topics: Acute Disease; Adolescent; Adult; Anaphylaxis; Asparaginase; BCG Vaccine; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Leucovorin; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphocytosis; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Skin Tests; Tuberculin Test; Vincristine | 1971 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
Remission induction in childhood leukemia with second course vincristine (NSC-67574) and prednisone (NSC-10023) therapy.
Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1970 |
[Treatment of acute lymphoblastic leukemia].
Topics: Adult; Antineoplastic Agents; Asparaginase; Child; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Prednisone; Remission, Spontaneous; Vinblastine; Vincristine | 1971 |
Comparison of methotrexate with 6-mercaptopurine-prednisone in treatment of acute leukemia in adults.
Topics: Adolescent; Adult; Drug Synergism; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone | 1967 |
Maintenance therapy in acute childhood leukemia.
Topics: Acute Disease; Child; Humans; Injections, Intravenous; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate | 1970 |
The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia.
Topics: Adolescent; Adult; Bone Marrow Cells; Child; Child, Preschool; Clinical Trials as Topic; Drug Synergism; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone | 1965 |
Induction of remission in acute leukemia of childhood by combination of prednisone and either 6-mercaptopurine or methotrexate.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone | 1966 |
972 other study(ies) available for methotrexate and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Male; Methods; Methotrexate; Mice; Thymidylate Synthase | 1979 |
Synthesis of aza homologues of folic acid.
Topics: Animals; Antineoplastic Agents; Folic Acid; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Male; Mice; Pediococcus; Streptococcus; Thymidylate Synthase | 1979 |
Methotrexate analogues. 10. Direct coupling of methotrexate and diethyl L-glutamate in the presence of peptide bond-forming reagents.
Topics: Animals; Cells, Cultured; Glutamates; Humans; Indicators and Reagents; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Stereoisomerism | 1978 |
Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.
Topics: Amides; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, Thin Layer; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Methotrexate; Mice; Rats | 1977 |
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Glutamates; Guanine; Humans; Leukemia L1210; Leukemia, Lymphoid; Mice; Pemetrexed; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
Topics: Acyltransferases; Animals; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Leukemia, Lymphoid; Liver; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
The 2-desamino and 2-desamino-2-methyl analogues of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture.
Topics: Aminopterin; Antineoplastic Agents; Cell Survival; Folic Acid Antagonists; Humans; Leukemia, Lymphoid; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Topics: Amides; Aminopterin; Animals; Cell Line; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice | 1986 |
Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters.
Topics: Animals; Cattle; Cell Line; DNA Replication; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Indicators and Reagents; Leukemia, Lymphoid; Liver; Methotrexate; Structure-Activity Relationship | 1984 |
Molecular characterization of human and rat organic anion transporter OATP-D.
Topics: Alprostadil; Amino Acid Sequence; Animals; Anions; Blotting, Northern; Brain Chemistry; Burkitt Lymphoma; Dinoprostone; DNA, Complementary; HeLa Cells; HL-60 Cells; Humans; K562 Cells; Leukemia, Lymphoid; Lung Neoplasms; Melanoma; Molecular Sequence Data; Oocytes; Organic Anion Transporters; Rats; RNA, Messenger; Xenopus laevis | 2003 |
Effect of SLCO1B1 Polymorphisms on High-Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leukemia, Lymphoid; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Models, Biological; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2021 |
Prescriptions for a toxic combination: use of methotrexate plus trimethoprim-sulfamethoxazole in the United States.
Topics: Adult; Aged; Ambulatory Care; Anti-Infective Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Health Care Surveys; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Pancytopenia; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prescriptions; Risk Assessment; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination; United States | 2014 |
Re: High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphatic leukemia.
Topics: Child; Dose-Response Relationship, Drug; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate; Recurrence | 2008 |
High dose methotrexate population pharmacokinetics and Bayesian estimation in patients with lymphoid malignancy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Dose-Response Relationship, Drug; Drug Monitoring; Forecasting; Humans; Infusions, Intravenous; Leukemia, Lymphoid; Methotrexate; Monte Carlo Method; Regression Analysis; Tissue Distribution | 2009 |
Five Chinese pediatric patients with leukemias possibly arising from immature natural killer cells: clinical features and courses.
Topics: Adolescent; Adult; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Etoposide; Female; Humans; Immunophenotyping; Infant; Killer Cells, Natural; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate; Mitoxantrone; Remission Induction; Treatment Outcome | 2011 |
Psychological factors and survival after bone marrow transplantation in patients with leukemia.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Mood Disorders; Sex Distribution | 2003 |
Chemical changes in the tissues of leukemic mice. II. The effects of amethopterin.
Topics: Animals; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Mice | 1961 |
Intrathecal aminopterin therapy of meningeal leukemia.
Topics: Aminopterin; Humans; Leucovorin; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate | 1963 |
Characterization of resistance to amethopterin, 8-azaguanine and several fluorinated pyrimidines in the murine lymphocytic neoplasm, P388.
Topics: Animals; Antineoplastic Agents; Azaguanine; Fluorouracil; Leukemia; Leukemia, Lymphoid; Lymphoma; Methotrexate; Mice; Nucleotides; Pyrimidines | 1962 |
TREATMENT OF LEUKAEMIAS.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antineoplastic Agents; Child; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate | 1963 |
LEUKEMIA. AN ANALYSIS OF 209 CASES FROM THE ELLIS FISCHEL STATE CANCER HOSPITAL.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Cancer Care Facilities; Child; Chlorambucil; Cobalt Isotopes; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Methotrexate; Neoplasms | 1963 |
DRUGS IN THE TREATMENT OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone; Triamcinolone | 1963 |
STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE.
Topics: Chromatography; Freeze Drying; Glucosephosphate Dehydrogenase; Humans; Hydrolases; L-Lactate Dehydrogenase; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lymphocytes; Methotrexate; Oxidoreductases; Tetrahydrofolates; Transferases | 1963 |
CHROMOSOME STUDIES IN LEUKEMIA. I. EVIDENCE FOR THE ORIGIN OF LEUKEMIC STEM LINES FROM ANEUPLOID MUTANTS.
Topics: Aneuploidy; Bone Marrow Examination; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Microscopy, Electron, Scanning Transmission; Neoplasms; Pathology; Prednisone | 1964 |
SERUM COMPLEMENT LEVELS IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA.
Topics: Adolescent; Antineoplastic Agents; Blood; Child; Complement System Proteins; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Serologic Tests; Spectrophotometry; Thioguanine | 1964 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, X-Linked; Geriatrics; Hodgkin Disease; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Mycosis Fungoides; Neoplasms; Pathology; Peptide Nucleic Acids; Physiology; Sarcoma; Severe Combined Immunodeficiency | 1964 |
ABNORMALITIES OF PURINE METABOLISM IN HUMAN LEUKEMIA.
Topics: Blood; Carbon Isotopes; Formates; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Metabolism; Methotrexate; Nucleic Acids; Uric Acid; Urine | 1964 |
INFLUENCE OF NUCLEATED CELLS ON SICKLING PHENOMENON.
Topics: Anemia, Sickle Cell; Eosinophilia; Erythrocytes; Humans; Kwashiorkor; Leukemia; Leukemia, Lymphoid; Leukocytes; Mercaptopurine; Methotrexate; Oxidation-Reduction; Polycythemia Vera; Prednisolone; Purpura; Purpura, Thrombocytopenic; Reticulocytes; Thalassemia | 1964 |
CHROMOSOME ABNORMALITY WITH LYMPHOID LEUKAEMIA.
Topics: Abnormalities, Drug-Induced; Busulfan; Child; Chromosome Aberrations; Chromosome Disorders; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Prednisolone; Toxicology | 1964 |
IN-VITRO SENSITIVITY TESTS OF LEUKAEMIC CELLS TO CHEMOTHERAPEUTIC AGENTS.
Topics: Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Geriatrics; Histological Techniques; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukocytosis; Mercaptopurine; Methotrexate; Mice; Polycythemia Vera; Purines; Research; Tissue Culture Techniques | 1964 |
THE CORRELATION BETWEEN TRANSPLANTED MOUSE AND HUMAN ACUTE LEUKEMIAS.
Topics: Aldehydes; Anilides; Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Vincristine | 1964 |
LEUKEMIA.
Topics: Antineoplastic Agents; Blood Transfusion; Bone Marrow Transplantation; Child; Chromosome Aberrations; Humans; Infections; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mortality; Neoplasms; Oncogenic Viruses; Research | 1964 |
[LONG-TERM REMISSIONS OF ACUTE LEUKEMIAS IN CHILDHOOD].
Topics: Adolescent; Child; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Prognosis | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mustard Plant; Neoplasms; Splenomegaly; Steroids; Uracil | 1964 |
INTRACRANIAL EXTRACEREBRAL HEMORRHAGES IN ACUTE LYMPHOCYTIC LEUKEMIA. A PROBLEM RESULTING FROM THE CHEMOTHERAPEUTIC MODIFICATIONS OF ACUTE LEUKEMIA.
Topics: Adolescent; Child; Hematoma; Hematoma, Epidural, Cranial; Hematoma, Subdural; Humans; Hydrocephalus; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Meninges; Mercaptopurine; Methotrexate; Pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiography; Subarachnoid Hemorrhage; Vinblastine | 1964 |
FURTHER OBSERVATION ON THE ROLE OF ANEUPLOIDY IN ACUTE LEUKEMIA.
Topics: Adolescent; Aneuploidy; Antineoplastic Agents; Bone Marrow Cells; Child; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Genetics, Medical; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Research; Vincristine | 1964 |
ACUTE LEUKEMIA TREATED WITH DIVIDED DOSES OF METHOTREXATE.
Topics: Bone Marrow Cells; Drug Therapy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prognosis; Statistics as Topic; Toxicology | 1965 |
EFFECT OF 5',5',5'-TRIFLUOROLEUCINE ON A NUMBER OF MOUSE LEUKAEMIAS.
Topics: Amino Acids; Animals; Chromatography; Hair; Leucine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Research; Skin | 1964 |
[STUDY OF FACTORS INFLUENCING SURVIVAL IN ACUTE LEUKEMIAS].
Topics: Adolescent; Adrenal Cortex Hormones; Child; Drug Therapy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms; Prednisone | 1964 |
IMPLICATIONS OF LONG-TERM SURVIVAL IN ACUTE STEM CELL LEUKEMIA OF CHILDHOOD TREATED WITH COMPOSITE CYCLIC THERAPY.
Topics: Child; Drug Therapy; Humans; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Periodicity; Prednisone; Prognosis; Statistics as Topic; Stem Cells | 1964 |
THE INTERPRETATION OF CLINICAL TRIALS.
Topics: Biomedical Research; Biometry; Blood Cell Count; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mathematics; Mercaptopurine; Methotrexate; Neoplasms; Therapeutics | 1965 |
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methotrexate; Multiple Myeloma; Neoplasms; Pathology; Primary Myelofibrosis; Sarcoma; Triethylenemelamine; Tuberculosis; Tuberculosis, Pulmonary; Urethane | 1965 |
MORPHOLOGIC ABNORMALITIES OF BONE MARROW CELLS INDUCED BY CHEMOTHERAPEUTIC AGENTS DURING TREATMENT OF LEUKEMIA.
Topics: Antineoplastic Agents; Bone Marrow Cells; Drug Therapy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Pathology; Prednisone; Toxicology; Vincristine | 1965 |
Inhibition of growth of amethopterinsensitive and amethopterin-resistant pairs of lymphocytic neoplasms by dietary folic-acid deficiency in mice.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental | 1962 |
Glioblastoma multiforme in a child with acute lymphoblastic leukemia: case report and review of literature.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Glioblastoma; Humans; Leukemia, Lymphoid; Magnetic Resonance Imaging; Male; Methotrexate; Tomography, X-Ray Computed | 2004 |
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Diffusion Magnetic Resonance Imaging; Edema; Female; Humans; Leukemia, B-Cell; Leukemia, Lymphoid; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Retrospective Studies | 2006 |
Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia, Lymphoid; Methotrexate; Peptide Synthases; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 2006 |
'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clone Cells; Cyclophosphamide; Eosinophilia; Female; Humans; Imatinib Mesylate; Leukemia, Lymphoid; Lymphoma, T-Cell, Peripheral; Male; Methotrexate; Middle Aged; mRNA Cleavage and Polyadenylation Factors; Oncogene Proteins, Fusion; Piperazines; Prevalence; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; T-Lymphocytes | 2007 |
The management of acute leukemia.
Topics: Adult; Anti-Bacterial Agents; Child; Cyclophosphamide; Hemorrhage; Humans; Infections; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Uric Acid; Vincristine | 1967 |
The eye as a sanctuary in acute lymphoblastic leukaemia.
Topics: Anterior Chamber; Antineoplastic Agents; Brain Neoplasms; Child, Preschool; Eye Neoplasms; Female; Humans; Injections, Spinal; Iris; Leukemia, Lymphoid; Male; Methotrexate | 1980 |
Comparison of three methods of central-nervous-system prophylaxis in childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Child; Child, Preschool; Hodgkin Disease; Humans; Infant; Infusions, Parenteral; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies; Risk | 1980 |
Can food influence the absorption of methotrexate in children with acute lymphoblastic leukaemia?
Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Eating; Fasting; Food; Humans; Intestinal Absorption; Leukemia, Lymphoid; Methotrexate; Milk Proteins | 1980 |
Methotrexate enteropathy?
Topics: Child; Female; Humans; Intestinal Diseases; Intestine, Small; Leukemia, Lymphoid; Methotrexate | 1981 |
Sister chromatid exchange in childhood malignancies.
Topics: Antineoplastic Agents; Cells, Cultured; Child; Crossing Over, Genetic; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Neoplasms; Sister Chromatid Exchange; Vincristine | 1983 |
High-dose neuroleptics for acute brain failure after intensive chemotherapy for acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Antipsychotic Agents; Asparaginase; Cytarabine; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Substance-Related Disorders | 1984 |
Seizures in childhood lymphoblastic leukaemia patients.
Topics: Central Nervous System; Child; Epilepsy; Follow-Up Studies; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Radiography; Retrospective Studies | 1984 |
Leukoencephalopathy and elevated levels of myelin basic protein in the cerebrospinal fluid of patients with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Brain; Brain Diseases; Child; Child, Preschool; Demyelinating Diseases; Humans; Leukemia, Lymphoid; Methotrexate; Myelin Basic Protein | 1980 |
[Clinical picture and course of adult lymphoblastic leukemia (author's transl)].
Topics: Adolescent; Adult; Aged; Asparaginase; Brain Neoplasms; Doxorubicin; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Life Expectancy; Male; Methotrexate; Prednisolone; Vincristine | 1981 |
[Experiences in meningeal leukemia prevention in acute juvenile leukemia].
Topics: Child; Cobalt Radioisotopes; Gold Radioisotopes; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate | 1981 |
Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug.
Topics: Erythrocytes; Folic Acid; Folic Acid Deficiency; Leukemia, Lymphoid; Liver; Methotrexate; Polyglutamic Acid | 1981 |
Acute lymphoblastic leukemia. Survival in children.
Topics: Actuarial Analysis; Antineoplastic Agents; Child; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Levamisole; Methotrexate; Prednisone; Prognosis; Vincristine | 1982 |
In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells.
Topics: Cell Line; Chromatography, High Pressure Liquid; Humans; Leukemia, Lymphoid; Methotrexate; Peptides; Polyglutamic Acid | 1983 |
Methotrexate metabolism by bone marrow cells from patients with leukemia.
Topics: Bone Marrow; Child; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Polyglutamic Acid | 1983 |
Are cognitive and educational development affected by age at which prophylactic therapy is given in acute lymphoblastic leukaemia?
Topics: Adolescent; Age Factors; Antineoplastic Agents; Brain; Child; Child Behavior Disorders; Child, Preschool; Combined Modality Therapy; Developmental Disabilities; Female; Humans; Infant; Injections, Spinal; Intelligence; Intelligence Tests; Leukemia, Lymphoid; Male; Mental Disorders; Methotrexate; Radiotherapy | 1983 |
Intellectual function after treatment for leukaemia or solid tumours.
Topics: Adolescent; Antineoplastic Agents; Brain; Child; Child, Preschool; Combined Modality Therapy; Developmental Disabilities; Female; Humans; Infant; Injections, Spinal; Intelligence; Intelligence Tests; Leukemia, Lymphoid; Male; Mental Disorders; Methotrexate; Neoplasms; Radiotherapy; Time Factors | 1983 |
Cranial computertomography in children with acute lymphatic leukemia (ALL) and non Hodgkin-lymphoma (NHL) after different methods of CNS-treatment.
Topics: Adolescent; Brain; Child; Child, Preschool; Cobalt Radioisotopes; Combined Modality Therapy; Female; Gold Colloid, Radioactive; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma; Male; Meningeal Neoplasms; Methotrexate; Radioisotope Teletherapy; Tomography, X-Ray Computed | 1983 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
[Cerebromeningeal location of chronic lymphoid leukemia. Rapid immunochemical diagnosis and complete remission by intrathecal chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebrospinal Fluid; Cyclophosphamide; Humans; Immunochemistry; Immunoglobulins; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Nervous System Neoplasms; Time Factors; Vincristine | 1983 |
[A case of acute T lymphoblastic leukemia with suppressor function].
Topics: Adult; Agammaglobulinemia; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Humans; Immunoglobulin G; Leukapheresis; Leukemia, Lymphoid; Male; Methotrexate; T-Lymphocytes, Regulatory; Vincristine | 1984 |
Therapy of acute lymphoblastic leukaemia in childhood: effects on the nervous system.
Topics: Asparaginase; Blood-Brain Barrier; Brain Diseases; Cyclophosphamide; Cytosine; Drug-Related Side Effects and Adverse Reactions; Humans; Leukemia, Lymphoid; Methotrexate; Peripheral Nervous System Diseases; Seizures; Vincristine | 1980 |
Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphocytic leukemia.
Topics: Brain Neoplasms; Child, Preschool; Glioblastoma; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Neoplasms, Radiation-Induced; Radiotherapy; Time Factors | 1981 |
[Cessation of treatment in childhood acute lymphatic leukemia. Long-term observations after meningosis prevention with intrathecal gold colloid radioisotopes and methotrexate].
Topics: Adolescent; Child; Child, Preschool; Female; Gold Colloid, Radioactive; Humans; Infant; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Time Factors | 1981 |
Meningosis prophylaxis with intrathecal 198Au-colloid and methotrexate in childhood acute lymphocytic leukemia.
Topics: Bone Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gold Colloid, Radioactive; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Prognosis | 1982 |
[Study on the treatment of acute lymphoblastic leukemia with T-cell markers in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Doxorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisolone; T-Lymphocytes; Vincristine | 1984 |
Interaction between human lymphoblastoid interferon and chemotherapeutic agents in vitro.
Topics: Antineoplastic Agents; B-Lymphocytes; Carmustine; Cyclophosphamide; Cytarabine; DNA Replication; Doxorubicin; Drug Therapy, Combination; Humans; In Vitro Techniques; Interferon Type I; Leukemia, Lymphoid; Methotrexate; T-Lymphocytes | 1984 |
CT-guided stereotactic placement of ventricular cannula.
Topics: Adult; Catheterization; Cerebral Ventricles; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Male; Methotrexate; Stereotaxic Techniques; T-Lymphocytes | 1984 |
Ovarian disease in childhood lymphoblastic leukaemia.
Topics: Brain Neoplasms; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Ovarian Neoplasms | 1983 |
[Central nervous system irradiation for children with leukemia].
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy Dosage; Radiotherapy, High-Energy; Skull; Spinal Cord | 1984 |
Methotrexate osteopathy.
Topics: Bone and Bones; Bone Diseases; Burkitt Lymphoma; Child, Preschool; Fractures, Bone; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Ossification, Heterotopic; Osteoporosis; Radiography | 1984 |
[Cerebral complications after irradiation and administration of methotrexate in lymphatic leukemia in the computerized tomography picture].
Topics: Adolescent; Brain Diseases; Child; Humans; Leukemia, Lymphoid; Methotrexate; Radiation Injuries; Tomography, X-Ray Computed | 1984 |
Efficacy and morbidity of central nervous system "prophylaxis" in childhood acute lymphoblastic leukemia: eight years' experience with cranial irradiation and intrathecal methotrexate.
Topics: Brain Neoplasms; Cataract; Child; Child, Preschool; Female; Humans; Injections, Spinal; Learning Disabilities; Leukemia, Lymphoid; Male; Methotrexate | 1983 |
The flag sign of chemotherapy.
Topics: Child, Preschool; Hair Diseases; Humans; Leukemia, Lymphoid; Male; Methotrexate; Pigmentation Disorders | 1983 |
Pharmacokinetics of oral methotrexate in children.
Topics: Absorption; Administration, Oral; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Fasting; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Metabolic Clearance Rate; Methotrexate; Tetrahydrofolate Dehydrogenase | 1983 |
Prolonged second remissions in childhood acute lymphocytic leukemia: a report from the Childrens Cancer Study Group.
Topics: Asparaginase; Bone Marrow Examination; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Recurrence, Local; Pilot Projects; Prednisone; Vincristine | 1983 |
LSA2-L2 protocol treatment of stage IV non-Hodgkin's lymphoma in children with partial and extensive bone marrow involvement.
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Prednisone; Prognosis; Time Factors; Vincristine | 1983 |
Neuropsychological study in patients with ALL. Two different CNS prevention therapies--cranial irradiation plus IT methotrexate vs. IT methotrexate alone.
Topics: Adolescent; Adult; Brain; Brain Diseases; Child; Child, Preschool; Dexamethasone; Female; Humans; Infant; Intelligence Tests; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Nervous System Neoplasms; Psychomotor Performance; Skull; Tomography, X-Ray Computed | 1983 |
[Efficacy and toxicity of preventive treatment with cranial irradiation and intrathecal methotrexate on the central nervous system in childhood lymphoblastic leukemia].
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Radiotherapy; Radiotherapy Dosage | 1983 |
Intractable diarrhoea associated with continuation of cytotoxic chemotherapy during acute infective enteritis.
Topics: Child, Preschool; Diarrhea; Enteritis; Female; Humans; Leukemia, Lymphoid; Methotrexate; Virus Diseases | 1983 |
[Case of disseminated necrotizing leukoencephalopathy following intrathecal methotrexate in acute lymphocytic leukemia].
Topics: Adult; Brain; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate | 1983 |
[Treatment of recurrence in children with acute lymphoblastic leukemias].
Topics: Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Recurrence; Vincristine | 1983 |
Treatment of childhood acute lymphoblastic leukemia in Malaysia, 1976-1982.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Doxorubicin; Female; Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Vincristine | 1983 |
[Liver damage after treatment of acute lymphatic leukemia in children].
Topics: Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Child; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Liver; Methotrexate | 1983 |
Long term follow-up of remission patients in adult acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Female; Follow-Up Studies; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Time Factors; Vincristine | 1983 |
Therapy of acute lymphocytic leukemia in childhood with intermediate dose methotrexate and CNS irradiation. A report of the ALL 77-02 study group.
Topics: Acute Disease; Antigens, Surface; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Risk | 1983 |
Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate.
Topics: Administration, Oral; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intramuscular; Leukemia, Lymphoid; Methotrexate; Patient Compliance | 1984 |
[Long-term toxicity of anti-leukemia therapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Infertility; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Radiotherapy | 1983 |
Utilization of an immunostaining technique to demonstrate heterogeneity in the content of dihydrofolate reductase in peripheral blast cells from a patient with acute lymphocytic leukemia.
Topics: Animals; Carcinoma; Cell Line; Clone Cells; Drug Resistance; Histocytochemistry; Humans; Immunoassay; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Mouth Neoplasms; Tetrahydrofolate Dehydrogenase | 1984 |
Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Circadian Rhythm; Female; Growth Hormone; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1984 |
[Current stage of leukemia treatment in children].
Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Folic Acid Antagonists; Humans; Infant; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Prognosis | 1983 |
Modification of oral methotrexate absorption in children with leukemia.
Topics: Absorption; Administration, Oral; Child; Child, Preschool; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate | 1984 |
High-dose methotrexate as part of remission maintenance therapy for childhood acute lymphocytic leukemia: a Pediatric Oncology Group pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Injections, Intravenous; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Pilot Projects | 1983 |
Second central nervous system prophylaxis in children with acute lymphoblastic leukemia who relapse after elective cessation of therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Time Factors | 1983 |
[Remission induction and maintenance with multi-drug regimen (modified LSA2L2) for acute lymphoblastic leukemia in children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisolone | 1983 |
Glucocorticoid receptors and steroid sensitivity of human acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytoplasm; Drug Resistance; Glucocorticoids; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Receptors, Glucocorticoid; Receptors, Steroid; Vincristine | 1984 |
Intermediate dose methotrexate and recurrent pleural effusions.
Topics: Adult; Humans; Leukemia, Lymphoid; Male; Methotrexate; Pleural Effusion; Recurrence | 1983 |
[Central nervous system involvement in adult acute leukemia].
Topics: Acute Disease; Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged | 1984 |
Treatment of meningeal relapse in childhood acute lymphoblastic leukemia. I. Results of craniospinal irradiation.
Topics: Acute Disease; Bone Marrow Diseases; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Immune Tolerance; Infant; Injections, Spinal; Intelligence Tests; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methods; Methotrexate; Recurrence | 1984 |
[Prophylactic central nervous system irradiation for childhood acute lymphoblastic leukemia].
Topics: Adolescent; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Prognosis; Radiotherapy Dosage; Risk; Skull; Spinal Cord | 1984 |
Failed central nervous system prophylaxis in children with acute lymphoblastic leukaemia: treatment and outcome.
Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Spinal Cord; Spinal Cord Neoplasms; Time Factors | 1984 |
Prolonged methotrexate infusions in children with acute leukemia in relapse and in remission and with medulloblastoma. Pharmacokinetics, toxicity and clinical results.
Topics: Actuarial Analysis; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Hematologic Diseases; Humans; Infusions, Parenteral; Injections, Spinal; Kinetics; Leukemia, Lymphoid; Medulloblastoma; Methotrexate; Recurrence | 1984 |
Protection of cells from methotrexate toxicity by 7-hydroxymethotrexate.
Topics: Acute Disease; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Humans; Leukemia, Lymphoid; Melanoma; Methotrexate; Time Factors | 1984 |
Slight impairment of psychomotor skills in children after treatment of acute lymphoblastic leukemia.
Topics: Achievement; Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Radiation; Humans; Leukemia, Lymphoid; Male; Methotrexate; Psychomotor Performance | 1984 |
In vitro approach to 7-hydroxymethotrexate interaction on methotrexate metabolism as tool of pharmacokinetic study.
Topics: Cell Line; Folic Acid Antagonists; Glutamates; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Models, Biological | 1983 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-1984. Childhood leukemia with progressive neurologic deterioration.
Topics: Adolescent; Amygdala; Brain; Brain Diseases; Hippocampus; Humans; Leukemia, Lymphoid; Male; Methotrexate; Necrosis; Radiography; Radiotherapy; Spinal Cord; Spinal Cord Diseases | 1984 |
7-Hydroxymethotrexate formation in a human lymphoblastic cell line.
Topics: Cell Line; Chromatography, High Pressure Liquid; Humans; Leukemia, Lymphoid; Methotrexate | 1984 |
[Pharmacokinetics of intravenous methotrexate in children with neoplasms of the hematopoietic system].
Topics: Child; Child, Preschool; Half-Life; Humans; Injections, Intravenous; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate | 1984 |
Outcome following late marrow relapse in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Diseases; Brain; Central Nervous System Diseases; Child; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Recurrence; Spinal Cord; Testicular Neoplasms; Time Factors | 1984 |
[6-Mercaptopurine and methotrexate, rational use in sight after 35 years?].
Topics: Animals; Child; Dogs; Half-Life; Humans; Infusions, Parenteral; Leukemia, Lymphoid; Lymphocytes; Mercaptopurine; Methotrexate; Purines; Pyrimidines | 1984 |
[Use of Ommaya reservoirs in the treatment of meningeal relapse of acute lymphoblastic leukemia].
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Meningitis; Methotrexate | 1984 |
Sequential combination of methotrexate and vindesine in previously treated children with acute leukemia. A phase I-II study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Drug Evaluation; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Methotrexate; Vinblastine; Vindesine | 1984 |
[Clinical and occult testicular relapses in children with acute lymphoblastic leukemia. Treated with the D.74 and pethema 7/78 protocols].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Combined Modality Therapy; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Spain; Testicular Neoplasms; Testis; Time Factors; Vincristine | 1984 |
[Prognosis of acute lymphatic leukemia in children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Prognosis | 1984 |
[Involvement of the central nervous system at the onset of acute lymphoblastic leukemia in children. Clinical and instrumental investigation].
Topics: Adolescent; Brain; Brain Diseases; Child; Child, Preschool; Coma; Electroencephalography; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Reflex, Abnormal; Vincristine | 1984 |
Vascular changes of methotrexate-related disseminated necrotizing leukoencephalopathy.
Topics: Adult; Arteries; Axons; Brain; Child; Combined Modality Therapy; Cytarabine; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukoencephalopathy, Progressive Multifocal; Male; Meningeal Neoplasms; Methotrexate; Necrosis; Veins | 1984 |
[Therapeutic results in non-T non-B acute lymphoblastic leukemia in the adult with intensive postremission chemotherapy].
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1984 |
Computed tomography of the brain following prophylactic treatment with irradiation therapy and intraspinal methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy; Tomography, X-Ray Computed | 1984 |
Methotrexate cerebrospinal fluid and serum concentrations after intermediate-dose methotrexate infusion.
Topics: Child; Child, Preschool; Humans; Infusions, Parenteral; Kinetics; Leucovorin; Leukemia, Lymphoid; Methotrexate | 1983 |
Paradoxical response of malignant melanoma to methotrexate in vivo and in vitro.
Topics: Animals; Cell Count; Cell Line; Cell Survival; Choriocarcinoma; Humans; Leucovorin; Leukemia, Lymphoid; Male; Melanoma; Methotrexate; Mice | 1983 |
[Prognostic subgrouping and early or late intensification of the treatment of childhood acute lymphocytic leukemia].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Doxorubicin; Drug Administration Schedule; Female; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Time Factors | 1983 |
[High dose methotrexate with citrovorum factor rescue therapy. (2) Measurement of methotrexate and its major metabolite, 7-hydroxymethotrexate in cerebrospinal fluid by high pressure liquid chromatography].
Topics: Child; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate | 1983 |
Trimethoprim interferes with serum methotrexate assay by the competitive protein binding technique.
Topics: Adult; Binding, Competitive; Chemical Phenomena; Chemistry; Drug Combinations; False Positive Reactions; Humans; Lacticaseibacillus casei; Leukemia, Lymphoid; Male; Methotrexate; Radioimmunoassay; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1980 |
Enterotoxic effect of methotrexate: does it influence the drug's absorption in children with acute lymphoblastic leukaemia?
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Humans; Intestinal Absorption; Leukemia, Lymphoid; Methotrexate; Xylose | 1981 |
[Effect of methotrexate on oxygen consumption of L1210 cells and their isolated mitochondria].
Topics: Animals; Cell Division; Cells, Cultured; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Mitochondria; Oxygen Consumption | 1981 |
Computed tomography brain scans in long term survivors of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Brain; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy, High-Energy; Time Factors; Tomography, X-Ray Computed | 1981 |
[CNS involvement in non-Hodgkin lymphomas. Clinical aspects and therapy (author's transl)].
Topics: Adolescent; Aged; Brain Neoplasms; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Meningitis; Methotrexate; Middle Aged | 1981 |
CSF infections complicating the management of neoplastic meningitis. Clinical features and results of therapy.
Topics: Adult; Breast Neoplasms; Catheters, Indwelling; Cerebral Ventricles; Cerebrospinal Fluid; Female; Humans; Leukemia, Lymphoid; Lung Neoplasms; Male; Meningeal Neoplasms; Meningitis; Methotrexate; Middle Aged; Staphylococcal Infections; Testicular Neoplasms; Thiotepa | 1982 |
[The plasma coagulation system in various stages of acute lymphoblastic leukemia].
Topics: Adolescent; Blood Coagulation Factors; Child; Child, Preschool; Daunorubicin; Factor V; Factor VIII; Humans; Leukemia, Lymphoid; Methotrexate; Prednisolone; Vincristine; Vitamin K | 1981 |
[Toxic effects of prophylaxis in meningeal leukemia: two cases of leukoencephalopathy (author's transl)].
Topics: Child; Humans; Infant; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Methotrexate | 1982 |
The treatment of childhood leukaemia in Hungary. On behalf of the Hungarian Working Party on Childhood Leukaemia.
Topics: Actuarial Analysis; Adolescent; Asparaginase; Central Nervous System; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Humans; Hungary; Infant; Leukemia, Lymphoid; Long-Term Care; Male; Methotrexate; Podophyllotoxin; Risk | 1982 |
Isolated testicular relapse in boys with acute lymphoblastic leukaemia: treatment and outcome.
Topics: Adolescent; Bone Marrow Diseases; Child; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Recurrence; Testicular Neoplasms | 1982 |
Meningeal leukemia complicating chronic lymphocytic leukemia.
Topics: Aged; Female; Follow-Up Studies; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Middle Aged | 1981 |
Liposome-encapsulated methotrexate interactions with human chronic lymphocytic leukemia cells.
Topics: Autoradiography; Biological Transport; Cell Compartmentation; Cells, Cultured; Humans; Ions; Leukemia, Lymphoid; Liposomes; Methotrexate | 1980 |
Necrotizing myelopathy associated with acute lymphoblastic leukemia. Case report and review of literature.
Topics: Adolescent; Autopsy; Humans; Leukemia, Lymphoid; Male; Methotrexate; Necrosis; Spinal Cord Diseases | 1980 |
[CNS prophylaxis in acute lymphoblastic leukemia (author's transl)].
Topics: Administration, Oral; Antineoplastic Agents; Brain Diseases; Child; Child, Preschool; Cobalt Radioisotopes; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy; Spinal Cord Diseases | 1980 |
Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts.
Topics: Biological Transport, Active; Cells, Cultured; Drug Resistance; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia, Lymphoid; Methotrexate; Tetrahydrofolate Dehydrogenase; Time Factors | 1980 |
Immunosuppression and serious infections in children with acute lymphoblastic leukaemia: a comparison of three chemotherapy regimes.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Immunoglobulins; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Mercaptopurine; Methotrexate; Mitosis; Neutrophils; Pneumonia | 1980 |
Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxis.
Topics: Adolescent; Brain; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous; Time Factors; Tomography, X-Ray Computed | 1980 |
Liver damage in children with acute leukaemia and non-Hodgkin's lymphoma on oral maintenance chemotherapy.
Topics: Adolescent; Alkaline Phosphatase; Antineoplastic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Time Factors | 1980 |
[Current approaches to the treatment of lymphoblastic leukemia in children].
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Radioisotope Teletherapy; Radiotherapy Dosage; Vincristine | 1980 |
[Present-day treatment of acute leukemia in children].
Topics: Antineoplastic Agents; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisolone; Radiotherapy Dosage; Vincristine | 1980 |
[DNA breaks in the leukocytes and tumor cells as an indicator of therapeutic activity of cytostatics].
Topics: Cytarabine; DNA; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Methotrexate; Nucleic Acid Denaturation | 1980 |
[ALL-study series of Hamburg (author's transl)].
Topics: Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1980 |
[Serial EEG-examinations in children undergoing chemotherapy of ALL according to the Berlin-West-protocol (author's transl)].
Topics: Adolescent; Asparaginase; Berlin; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Electroencephalography; Germany, West; Humans; Infant; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisone; Registries; Vincristine | 1980 |
Basal ganglia calcification on CT scanning in children with acute lymphocytic leukemia.
Topics: Basal Ganglia Diseases; Calcinosis; Child; Child, Preschool; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Tomography, X-Ray Computed; Vincristine | 1980 |
VM-26 and cytosine arabinoside combination chemotherapy for initial induction failures in childhood lymphocytic leukemia.
Topics: Adolescent; Antineoplastic Agents; Bone Marrow Diseases; Child; Child, Preschool; Cytarabine; Drug Resistance; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Podophyllotoxin; Remission, Spontaneous; Teniposide | 1980 |
[Treatment of relapse in acute lymphoblastic leukaemia of childhood (author's transl)].
Topics: Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Recurrence; Skull; Vincristine | 1980 |
[Methotrexate resistance in acute lymphatic leukemia treated intrathecally].
Topics: Adult; Drug Resistance; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate | 1980 |
Prolonged remission in a case with acute lymphatic leukemia.
Topics: Antineoplastic Agents; Child, Preschool; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1980 |
Absorption of methotrexate under standardized conditions in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Intestinal Absorption; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1980 |
Changes of CSF-protein pattern in children with acute lymphoblastic leukemia during prophylactic CNS therapy (Berlin protocol).
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Drug Therapy, Combination; Electrophoresis, Agar Gel; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Skull | 1980 |
Pharmacokinetics of intermediate dose methotrexate in patients of non-Hodgkin's lymphoma and acute lymphocytic leukaemia.
Topics: Adolescent; Adult; Biological Availability; Child; Child, Preschool; Half-Life; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate | 1980 |
Life-threatening neuropathy and hepatotoxicity in infants during induction therapy for acute lymphoblastic leukemia.
Topics: Asparaginase; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Retrospective Studies; Vincristine | 1981 |
Favorable response to maintenance therapy of second or subsequent remissions in childhood acute lymphocytic leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Recurrence; Remission, Spontaneous; Vincristine | 1980 |
Karyotypic analysis of methotrexate-resistant and sensitive mouse L5178Y cells.
Topics: Animals; Cell Line; Chromosome Mapping; Chromosomes; Drug Resistance; Gene Amplification; Genes; Karyotyping; Leukemia, Lymphoid; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1981 |
Progression of methotrexate-induced leukoencephalopathy in children with leukemia.
Topics: Brain; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Substance-Related Disorders | 1981 |
Near-haploid acute lymphoblastic leukemia: a unique subgroup with a poor prognosis?
Topics: Acute Disease; Adolescent; Bone Marrow Examination; Brain Neoplasms; Child; Daunorubicin; Female; Haploidy; Humans; Injections, Spinal; Karyotyping; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Prognosis; Vincristine | 1981 |
The investigation of late cytogenetic effects in children with acute leukaemia in long remission and off all chemotherapy.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human; Crossing Over, Genetic; Female; Follow-Up Studies; Humans; Infant; Karyotyping; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Sister Chromatid Exchange | 1981 |
Effect of leukaemia therapy on neutrophil chemotaxis.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Chemotaxis, Leukocyte; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neutrophils; Time Factors | 1981 |
Long-term survival (cures) in childhood acute leukemia. Follow-up of nine cases of acute lymphatic leukemia and two of acute myelogenous leukemia with complete remission lasting more than 10 years, three of them with normal progeny.
Topics: Adolescent; Ambulatory Care; Antineoplastic Agents; Child; Child, Preschool; Female; Follow-Up Studies; Hospitalization; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Pediatrics; Prednisone; Pregnancy; Time Factors; Vincristine | 1980 |
[Treatment of acute lymphoblastic leukaemia in children over twenty years (author's transl)].
Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Humans; Infant; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisone; Testicular Neoplasms; Vincristine | 1981 |
[Changes in the meningogram during amethopterin treatment of meningosis leucaemica].
Topics: Cerebrospinal Fluid; Child; Humans; Leukemia, Lymphoid; Lymphocytes; Meningeal Neoplasms; Methotrexate | 1981 |
Enhancement of the white matter following prophylactic therapy of the central nervous system for leukemia: radiation effects and methotrexate leukoencephalopathy.
Topics: Adolescent; Brain; Humans; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Radiation Injuries; Radiotherapy Dosage; Tomography, X-Ray Computed | 1981 |
[Evaluation of reinductions in a modern protocol for the treatment of childhood acute lymphoblastic leukaemias. Analysis of the D-74 protocol (author's transl)].
Topics: Antineoplastic Agents; Asparaginase; BCG Vaccine; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1981 |
Small bowel enterocyte abnormalities caused by methotrexate treatment in acute lymphoblastic leukaemia of childhood.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Humans; Intestinal Mucosa; Jejunum; Leukemia, Lymphoid; Methotrexate; Microscopy, Electron; Time Factors | 1981 |
[Presentation of the cooperative study COALL-80 on treatment of childhood ALL (author's transl)].
Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Vincristine | 1981 |
[Iatrogenic liver fibrosis in a child as a result of treatment of lymphoblastic leukemia].
Topics: Child, Preschool; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Methotrexate | 1981 |
[Clinical application of Ommaya reservoir for adult central nervous system leukemia (author's transl)].
Topics: Adolescent; Adult; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Nimustine; Nitrosourea Compounds | 1981 |
Treatment of adult lymphoblastic leukaemia using cyclical chemotherapy with three combinations of four drugs (COAP, POMP, TRAP schedule).
Topics: Adolescent; Adult; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Thioguanine; Vincristine | 1981 |
Antagonism of drugs used in leukaemia therapy to the killing of human lymphoblastoid cells by steroid.
Topics: Cell Line; Cell Survival; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone | 1981 |
The development of cerebral CT changes during treatment of acute lymphocytic leukemia in childhood.
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy; Time Factors; Tomography, X-Ray Computed | 1981 |
Alternative metabolic fates of thymine nucleotides in human cells.
Topics: Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Cell Line; DNA; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Methotrexate; Thymine Nucleotides | 1981 |
Metabolism of thymine nucleotides synthesized via the 'de novo' mechanism in normal, megaloblastic and methotrexate-treated human cells and in a lymphoblastoid cell line.
Topics: Bone Marrow; Bone Marrow Cells; Cell Line; Cells, Cultured; Erythrocytes, Abnormal; Humans; Leukemia, Lymphoid; Lymphocytes; Megaloblasts; Methotrexate; Thymine Nucleotides | 1981 |
Inhibition of colony-forming cells from bone marrow of leukemic patients by 3-oxauracil.
Topics: Antimetabolites; Bone Marrow; Cells, Cultured; Cisplatin; Colony-Forming Units Assay; Drug Evaluation; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Oxazines; Uracil | 1981 |
The treatment of primary childhood acute lymphocytic leukemia with intermediate dose methotrexate.
Topics: Adolescent; Antineoplastic Agents; Brain; Child; Child, Preschool; Drug Administration Schedule; Evaluation Studies as Topic; Follow-Up Studies; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Recurrence; Risk | 1981 |
[Comparison of the results of treatment of lymphoblastic leukemia in children by different methods].
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Regression, Spontaneous; Prednisone; Vincristine | 1981 |
Methotrexate absorption in children with acute lymphoblastic leukemia.
Topics: Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Intestinal Absorption; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Recurrence; Time Factors | 1981 |
Neurologic sequelae of methotrexate and ionizing radiation: a new classification.
Topics: Adolescent; Adult; Brain; Brain Diseases; Child, Preschool; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Necrosis; Radiotherapy; Radiotherapy Dosage; Systems Theory; Time Factors | 1981 |
Asparaginase and methotrexate combination chemotherapy in relapsed acute lymphoblastic leukemia in adults.
Topics: Adolescent; Adult; Anaphylaxis; Asparaginase; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ifosfamide; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Recurrence | 1981 |
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukaemia in Norway. Report on a national treatment program.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Male; Methotrexate; Norway; Testicular Neoplasms | 1981 |
[Leukoencephalopathy in childhood leukemia (author's transl)].
Topics: Adolescent; Brain Diseases; Central Nervous System; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy | 1981 |
[Neurotoxicity of intrathecal methotrexate administration and external meningoencephalic irradiation in carcinomatous meningitis. Must one reconsider therapeutic technics for meningitis in acute lymphoblastic leukemias and non-Hodgkin's lymphomas?].
Topics: Brain Diseases; Central Nervous System; Humans; Leukemia, Lymphoid; Lymphoma; Meningitis; Methotrexate | 1981 |
[Therapeutic methods for meningitis in acute lymphoblastic leukemia and Hodgkin's lymphoma].
Topics: Brain; Hodgkin Disease; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Meningitis; Methotrexate | 1981 |
Poor-prognosis acute lymphoblastic leukemias.
Topics: Adolescent; Adult; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Radiotherapy Dosage; Vincristine | 1982 |
Treatment of childhood acute leukemia.
Topics: Acute Disease; Child; Child, Preschool; Doxorubicin; Humans; Hydrocortisone; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisolone; Vincristine | 1980 |
Recent therapeutic results of childhood acute leukemia and some problems.
Topics: Acute Disease; Bacterial Infections; Child; Child, Preschool; Humans; Leukemia; Leukemia, Lymphoid; Methotrexate; Prednisolone; Thioinosine; Vincristine | 1980 |
Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy.
Topics: Adolescent; Allopurinol; Asparaginase; Female; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Thioinosine; Uric Acid; Vincristine; Xanthine Oxidase | 1981 |
Serum profiles of methotrexate after its administration in children with acute lymphoblastic leukaemia.
Topics: Administration, Oral; Child; Humans; Injections, Intramuscular; Injections, Intravenous; Leukemia, Lymphoid; Methotrexate; Time Factors | 1982 |
Prophylactic treatment of the central nervous system in acute lymphoblastic leukemia. CT findings in 45 children off therapy.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radiotherapy; Tomography, X-Ray Computed | 1981 |
Calcified cerebral necrosis following ALL therapy.
Topics: Adolescent; Brain; Calcinosis; Female; Humans; Leukemia, Lymphoid; Methotrexate; Necrosis; Radiotherapy | 1981 |
[An adult case of long-term survivor of acute lymphoblastic leukemia (author's transl)].
Topics: Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisolone; Recurrence; Vincristine | 1981 |
[Treatment of acute lymphoblastic leukemia. Results with 1,192 patients].
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Levamisole; Methotrexate; Prednisone; Vincristine | 1981 |
Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients.
Topics: Actuarial Analysis; Adolescent; Adult; Aging; Bacterial Infections; Child; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Receptors, Antigen, B-Cell; Retrospective Studies; Thioinosine; Vincristine | 1982 |
[Intensive chemotherapy of acute lymphoblastic leukemia in childhood: evaluation of our experience].
Topics: Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Thioguanine; Vincristine | 1981 |
Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia.
Topics: Asparaginase; Brain Neoplasms; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Karyotyping; Leukemia, Lymphoid; Methotrexate; Ploidies; Podophyllin; Prednisone; Prognosis; Vincristine | 1982 |
Pharmacokinetics of methotrexate following intravenous and intraventricular administration in acute lymphocytic leukemia and non-Hodgkin's lymphoma.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Female; Half-Life; Humans; Infant; Injections, Intravenous; Injections, Intraventricular; Kinetics; Leukemia, Lymphoid; Lymphoma; Male; Meningeal Neoplasms; Methotrexate; Nervous System Neoplasms | 1982 |
Immediate and long-term posttherapy neuropsychologic performance in children with acute lymphoblastic leukemia treated without central nervous system radiation.
Topics: Adolescent; Antineoplastic Agents; Bender-Gestalt Test; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Rhabdomyosarcoma; Stanford-Binet Test; Time Factors; Wechsler Scales | 1982 |
[Chance of a second remission in acute juvenile lymphoblastic leukemia with favorable prognosis].
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Doxorubicin; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Vincristine | 1982 |
[Progress in the treatment of juvenile leukemias].
Topics: Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Risk; Thioguanine; Vincristine | 1982 |
Cranial computed tomography during treatment of childhood lymphocytic leukemia. Factors predisposing to abnormalities.
Topics: Adolescent; Brain; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy; Spinal Cord Neoplasms; Tomography, X-Ray Computed | 1982 |
Results of induction therapy with vincristine and prednisone alone in adult acute lymphoblastic leukemia: report of 43 patients and review of the literature.
Topics: Adolescent; Adult; Aged; Aging; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Vincristine | 1982 |
Chemotherapy does not affect the development of inter-Sertoli junctions in childhood leukaemia.
Topics: Animals; Antineoplastic Agents; Biopsy; Child; Child, Preschool; Drug Therapy, Combination; Humans; Intercellular Junctions; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mice; Prednisone; Rabbits; Rats; Sertoli Cells; Testis; Vincristine | 1982 |
The use of intermediate dose methotrexate in increased risk childhood acute lymphoblastic leukemia. A comparison of three versus six courses.
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Cytarabine; Dexamethasone; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemia, Lymphoid; Liver; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1982 |
Purine modulation of methotrexate cytotoxicity in mammalian cell lines.
Topics: Animals; Cell Line; Cell Survival; Deoxyribonucleotides; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Melanoma; Methotrexate; Mice; Purines | 1982 |
Jejunal crypt cell abnormalities associated with methotrexate treatment in children with acute lymphoblastic leukaemia.
Topics: Child; Child, Preschool; Humans; Intestinal Mucosa; Jejunum; Leukemia, Lymphoid; Methotrexate; Microscopy, Electron; Mitotic Index | 1982 |
Disposition of intermediate-dose methotrexate in children with acute lymphocytic leukemia.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1982 |
Adult acute lymphoblastic leukemia. Response to therapy according to presenting features in 62 patients.
Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1982 |
[Long-term therapy of acute lymphoblastic leukemia. Protocol 10-LA-72].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged | 1982 |
Pharmacokinetics of low-dose methotrexate in children receiving maintenance therapy for acute lymphoblastic leukaemia.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Female; Glomerular Filtration Rate; Humans; Injections, Intravenous; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1982 |
Methotrexate-induced severe pneumonitis.
Topics: Child, Preschool; Humans; Leukemia, Lymphoid; Male; Methotrexate; Pneumonia | 1982 |
Use of cytosar in pediatric acute myelocytic leukemia and leukemic meningitis.
Topics: Age Factors; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Hydrocortisone; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Meningitis; Methotrexate | 1982 |
Adverse reactions following methotrexate chemoprophylaxis in childhood lymphocytic leukemia.
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate | 1982 |
Management of childhood acute leukaemia in Singapore.
Topics: Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Singapore; Vincristine | 1982 |
[Effects of prophylactic treatment of central nervous system leukemia in children. Analysis of CNS prophylactic treatment with cyclic high dose multichemotherapy, craniospinal irradiation, and high dose infusion of MTX].
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Invasiveness; Radiotherapy Dosage; Spinal Cord | 1982 |
[Two cases of central nervous system leukemia which responded excellently to intra-arterial injection of ACNU].
Topics: Adolescent; Adult; Brain Neoplasms; Humans; Injections, Intra-Arterial; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate; Nimustine; Nitrosourea Compounds | 1982 |
[Results of 2 protocols in the treatment of acute lymphoid leukemia in children, according to prognostic factors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; BCG Vaccine; Child; Combined Modality Therapy; Doxorubicin; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Vincristine; Vindesine | 1982 |
Pneumonia during therapy for childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukopenia; Methotrexate; Pneumonia; Pneumonia, Pneumocystis; Surveys and Questionnaires; Time Factors | 1980 |
Methotrexate/L-asparaginase combination chemotherapy for patients with acute leukemia in relapse: a study of 36 children.
Topics: Acute Disease; Adolescent; Asparaginase; B-Lymphocytes; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; T-Lymphocytes | 1980 |
CT studies before and after CNS treatment for acute lymphoblastic leukemia and malignant non-hodgkin's lymphoma in childhood.
Topics: Adolescent; Brain; Cerebral Ventriculography; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Tomography, X-Ray Computed | 1980 |
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukemia in Norway. Preliminary results of a national treatment program.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Recurrence, Local; Norway; Pilot Projects | 1981 |
The acute management of intrathecal methotrexate overdose: pharmacologic rationale and guidelines.
Topics: Adrenal Cortex Hormones; Brain Diseases; Child; Child, Preschool; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate | 1981 |
Low- and high-risk non-T and non-B and T-cell acute lymphoid leukemia (ALL) in childhood: different duration of remission and survival.
Topics: Adolescent; Asparaginase; B-Lymphocytes; Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Receptors, Antigen, B-Cell; Remission, Spontaneous; Risk; T-Lymphocytes; Vincristine | 1981 |
Inhibition by chemotherapeutic agents of human bone marrow progenitor cells and clonogenic cells of a lymphoblastic cell line.
Topics: Cell Line; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Daunorubicin; Hematopoietic Stem Cells; Humans; Hydrocortisone; Leucovorin; Leukemia, Lymphoid; Methotrexate; Vincristine | 1981 |
Influence of co-trimoxazole on methotrexate pharmacokinetics in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Drug Combinations; Drug Interactions; Female; Humans; Intestinal Absorption; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Protein Binding; Radioimmunoassay; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1981 |
Methotrexate in the plasma and cerebrospinal fluid of children treated with intermediate dose methotrexate.
Topics: Brain Neoplasms; Child; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate | 1981 |
Clinical use of methotrexate--with emphasis on use of high doses.
Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Humans; Infant; Injections, Spinal; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice | 1981 |
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Interactions; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase | 1982 |
The use of subcutaneous cerebrospinal fluid reservoirs for the prevention and treatment of meningeal relapse of acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Cerebral Ventricles; Cerebrospinal Fluid; Child; Cytarabine; Dexamethasone; Drainage; Drug Therapy, Combination; Humans; Infant; Leucovorin; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Skull | 1982 |
Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia.
Topics: Adolescent; Anti-Infective Agents; Antineoplastic Agents; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Jejunum; Leukemia, Lymphoid; Malabsorption Syndromes; Male; Methotrexate; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1982 |
The treatment of acute lymphoblastic leukaemia.
Topics: Adult; Bone Marrow Transplantation; Child; Cytarabine; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Podophyllotoxin; Prognosis; Transplantation, Homologous | 1980 |
[Immunosuppressive effect of cytostatics].
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Aziridines; Bone Marrow Transplantation; Carubicin; Cyclophosphamide; Drug Therapy, Combination; Graft Survival; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Organophosphorus Compounds; Prednisolone; Purines; Thioguanine; Transplantation, Homologous; Vincristine | 1980 |
Transient dyserythropoiesis in repopulated human bone marrow following transplantation: an ultrastructural study.
Topics: Anemia, Aplastic; Bone Marrow; Bone Marrow Transplantation; Erythroblasts; Erythropoiesis; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Microscopy, Electron; Mitochondria | 1982 |
[New development in clinical bone marrow transplantation in leukemia].
Topics: Bone Marrow Transplantation; Cyclosporins; Graft vs Host Reaction; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Prognosis | 1981 |
Methotrexate levels in the interstitial space and seminiferous tubule of rat testis.
Topics: Animals; Extracellular Space; Infusions, Parenteral; Leukemia, Lymphoid; Male; Methotrexate; Rats; Rats, Inbred Strains; Recurrence; Seminiferous Tubules; Testis | 1982 |
Management of childhood leukemia.
Topics: Adolescent; Brain; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasm Recurrence, Local | 1982 |
Dementia and central nervous system involvement in chronic lymphocytic leukaemia.
Topics: Central Nervous System Diseases; Dementia; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged | 1982 |
Cranial computerized tomography in childhood leukemia.
Topics: Brain Diseases; Child; Humans; Leukemia, Lymphoid; Male; Methotrexate; Tomography, X-Ray Computed | 1980 |
[A case of chronic lymphocytic leukemia responding well to combination chemotherapy with cytosine arabinoside, methotrexate and prednisolone (author's transl)].
Topics: Cytarabine; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisolone | 1980 |
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
Topics: Antineoplastic Agents; Biological Transport; Blotting, Western; Catalysis; Cell Membrane; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Peptide Synthases; Polyglutamic Acid; Tetrahydrofolates; Tumor Cells, Cultured | 1993 |
Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).
Topics: Cell Line; Drug Resistance; gamma-Glutamyl Hydrolase; Humans; Hydrogen-Ion Concentration; Kinetics; Leukemia, Lymphoid; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1993 |
Neuropsychological and neurological outcome after relapse of lymphoblastic leukaemia.
Topics: Age Factors; Brain; Child; Child, Preschool; Cognition Disorders; Cranial Irradiation; Developmental Disabilities; Education; Female; Growth Disorders; Humans; Infant; Intelligence; Leukemia, Lymphoid; Leukemic Infiltration; Male; Methotrexate; Nervous System Diseases; Radiation Injuries; Radiotherapy; Recurrence; Whole-Body Irradiation | 1994 |
Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.
Topics: Acyltransferases; Animals; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Leukemia, Lymphoid; Methotrexate; Mice; Peptide Synthases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Tumor Cells, Cultured | 1994 |
Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Glycosylation; Humans; Leukemia, Lymphoid; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Methotrexate and gamma-tert-butyl methotrexate transport in CEM and CEM/MTX human leukemic lymphoblasts.
Topics: Cell Line; Drug Resistance; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1993 |
5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines.
Topics: Biological Transport; Carrier Proteins; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Receptors, Cell Surface; Stereoisomerism; Substrate Specificity; Tetrahydrofolates; Tritium; Tumor Cells, Cultured | 1993 |
gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Biomarkers; Child; Child, Preschool; gamma-Glutamyl Hydrolase; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Peptide Synthases; Polyglutamic Acid | 1997 |
Long-term remission induced by corticosteroids, cyclophosphamide, and methotrexate in a patient with natural killer cell leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Humans; Killer Cells, Natural; Leukemia, Lymphoid; Methotrexate; Prednisolone; Remission Induction | 2000 |
Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice.
Topics: Adult; Animals; Antimetabolites, Antineoplastic; Apoptosis; Fas Ligand Protein; fas Receptor; Female; Gene Expression; Humans; Immunophenotyping; Leukemia, Lymphoid; Leukemic Infiltration; Liver; Lung; Male; Membrane Glycoproteins; Methotrexate; Mice; Mice, Transgenic; Middle Aged | 2000 |
Acute T-lymphoblastic leukemia relapsed with the character of myeloid/natural killer cell precursor phenotype: a case report.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cell Lineage; Combined Modality Therapy; Daunorubicin; Disease Progression; Fatal Outcome; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Genes, Immunoglobulin; Glycophorins; HLA-DR Antigens; Humans; Immunophenotyping; Killer Cells, Natural; Leukemia, Lymphoid; Male; Methotrexate; Myeloid Cells; Neoplasm Proteins; Neoplastic Stem Cells; Peroxidase; Prednisolone; Recurrence; Remission Induction; T-Lymphocyte Subsets; Transplantation, Homologous; Vincristine | 2002 |
HL-A-identical marrow transplants in aplastic anemia, acute leukemia, and lymphosarcoma employing cyclophosphamide.
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Cells; Bone Marrow Transplantation; Child; Cyclophosphamide; Graft Rejection; Graft vs Host Reaction; Histocompatibility Antigens; HLA Antigens; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma, Non-Hodgkin; Methotrexate; Transplantation, Homologous | 1976 |
One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation.
Topics: Antilymphocyte Serum; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Graft Rejection; Graft vs Host Reaction; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Life Expectancy; Methotrexate; Nitrosourea Compounds; Radiotherapy; T-Lymphocytes | 1977 |
Letter: Altered plasma pharmacokinetics of methotrexate administered intrathecally.
Topics: Administration, Oral; Adolescent; Blood Specimen Collection; Child; Half-Life; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Time Factors | 1975 |
Combination chemotherapy of Rauscher leukemia and ascites tumors by narcissus alkaloid with standard drugs and effect on cellular immunity.
Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Blood Cells; Carcinoma, Ehrlich Tumor; Carmustine; Cells, Cultured; Cyclophosphamide; Dactinomycin; Daunorubicin; Drug Synergism; Drug Therapy, Combination; Emetine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Inbred BALB C; Plants, Medicinal; Rauscher Virus; Spleen; Streptonigrin; Vincristine | 1975 |
Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy.
Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hepatitis B; Hepatitis B Antigens; Humans; Immunosuppression Therapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Prednisolone; Pregnancy; Substance Withdrawal Syndrome; Vincristine | 1975 |
[Immunologic parameters in acute lymphatic leukemias in the course of different types of chemotherapy (author's transl)].
Topics: Child; Daunorubicin; gamma-Globulins; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Methotrexate; Skin Tests; Time Factors; Vincristine | 1975 |
Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cytarabine; Ethidium; Fluorometry; Humans; Leucovorin; Leukemia, Lymphoid; Melanoma; Methotrexate; Neoplasms; Staining and Labeling | 1976 |
[Studies on the effect of various kinds of cytostatic therapy on the cellular immune reaction in children with acute lymphatic leukemia].
Topics: Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Mercaptopurine; Methotrexate; Vincristine | 1976 |
Ocular involvement in leukaemia. Report of three cases.
Topics: Adult; Child, Preschool; Cytarabine; Female; Fundus Oculi; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Ophthalmoscopy; Optic Atrophy; Optic Disk; Radiotherapy Dosage; Retinal Diseases | 1977 |
Brain damage in relation to irradiation and chemotherapy of central nervous system.
Topics: Acid Phosphatase; Aspartate Aminotransferases; Brain; Brain Damage, Chronic; Carbohydrates; Cerebrospinal Fluid Proteins; Child; Creatine Kinase; Cyclic AMP; Humans; L-Lactate Dehydrogenase; Leukemia, Lymphoid; Methotrexate; Radiotherapy | 1977 |
[Quantitative behavior of eosinophil granulocytes in the bone marrow of children with acute lymphoblastic leukemia].
Topics: Bone Marrow Cells; Cell Count; Child; Child, Preschool; Eosinophils; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone | 1978 |
Acute encephalopathy after initiation of cranial irradiation for meningeal leukaemia.
Topics: Acute Disease; Adolescent; Brain; Brain Diseases; Child; Child, Preschool; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy; Radiotherapy Dosage; Time Factors | 1978 |
Testicular histology after combination chemotherapy in childhood for acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Fertility; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Testis; Vincristine | 1978 |
Acute encephalopathy after initiation of cranial irradiation for meningeal leukaemia.
Topics: Acute Disease; Brain Diseases; Child, Preschool; Coma; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Radiotherapy | 1978 |
Preventive cranial irradiation in the treatment of acute lymphocytic leukemia in children.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy, High-Energy; Recurrence; Remission, Spontaneous; Skull | 1978 |
[Unusual CT skull findings after preventive CNS treatment of acute leukemia in children].
Topics: Central Nervous System; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Methotrexate; Radiotherapy Dosage; Radiotherapy, High-Energy; Skull; Time Factors; Tomography, X-Ray Computed | 1979 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
[Carcinoma of the liver in a child after seven-year complete remission of acute lymphoblastic leukaemia(author's transl)].
Topics: Carcinoma, Hepatocellular; Child; Female; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Liver Neoplasms; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors | 1975 |
Leukemia in children with Wilms tumor.
Topics: Acute Disease; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Humans; Kidney Neoplasms; Leukemia, Lymphoid; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Vincristine; Wilms Tumor | 1975 |
Childhood cancer: the improving prognosis.
Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Rhabdomyosarcoma; Teniposide; Thioguanine; Vincristine; Wilms Tumor | 1976 |
Hepatoma in a child with methotrexate-induced hepatic fibrosis.
Topics: Carcinoma, Hepatocellular; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphoid; Liver; Liver Cirrhosis; Liver Neoplasms; Methotrexate | 1977 |
A peculiar brain scan pattern in necrotizing leukoencephalopathy after treatment for CNS-leukaemia.
Topics: Brain; Brain Neoplasms; Cerebral Ventricles; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Necrosis; Radionuclide Imaging | 1979 |
[Combination chemotherapy of acute lymphoid leukaemia in children combined with prophylactic cranial irradiation (author's transl)].
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Remission, Spontaneous; Skull; Vincristine | 1977 |
Blindness during remission in two patients with acute lymphoblastic leukemia: a possible complication of multimodality therapy.
Topics: Acute Disease; Adult; Blindness; Brain; Child, Preschool; Cytarabine; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Optic Nerve; Radiotherapy; Remission, Spontaneous | 1977 |
Cerebral calcifications associated with intrathecal methotrexate therapy in acute lymphocytic leukemia.
Topics: Brain Diseases; Calcinosis; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate | 1977 |
Remission maintenance of adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Brain Neoplasms; Cyclophosphamide; Female; Head; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Remission, Spontaneous; Spinal Cord Neoplasms | 1977 |
Intermittent chemotherapy and BCG in continuation therapy of children with acute lymphocytic leukemia.
Topics: BCG Vaccine; Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Remission, Spontaneous; Vincristine | 1977 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Male; Methotrexate; Neoplasms; Neuroblastoma; Prednisone; Pregnancy; Procarbazine; Remission, Spontaneous; Testicular Neoplasms; Uterine Neoplasms; Vincristine | 1977 |
Insulin and growth hormone secretion in a leukaemic girl with hypothalamic syndrome.
Topics: Arginine; Child; Female; Growth Hormone; Humans; Insulin; Insulin Secretion; Leukemia, Lymphoid; Methotrexate; Obesity; Triamcinolone; Vincristine | 1977 |
Renal failure secondary to leukemic infiltration of the kidneys.
Topics: Calcium; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Neoplasms; Leukemia, Lymphoid; Methotrexate; Middle Aged; Neoplasm Metastasis; Phosphates; Radiotherapy Dosage; Uric Acid; Urography | 1977 |
[Meningosis-prophylaxis in the treatment of acute lymphoblastic leukemia and of non-Hodgkin's lymphomas (author's transl)].
Topics: Child; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Meninges; Methotrexate; Neoplasm Metastasis; Remission, Spontaneous | 1977 |
Analysis of treatment in childhood leukaemia. III. Independence of lymphopenia induced by irradiation and by chemotherapy.
Topics: Antimetabolites, Antineoplastic; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Radiation Injuries; Radiotherapy | 1977 |
Leukaemia in children.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Immunotherapy; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1977 |
Multiple-drug chemotherapy for acute leukemia The TRAMPCOL regimen: results in 86 patients.
Topics: Adolescent; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Methotrexate; Prednisolone; Remission, Spontaneous; Thioguanine; Vincristine | 1977 |
Complete remodeling of the vertebrae in a child successfully treated for acute lymphocytic leukemia (ALL).
Topics: Bone Regeneration; Child; Cyclophosphamide; Daunorubicin; Fractures, Spontaneous; Humans; Leukemia, Lymphoid; Lumbar Vertebrae; Male; Mercaptopurine; Methotrexate; Prednisone; Thoracic Vertebrae; Vincristine | 1977 |
Antimetaboliths in the prophylaxis and treatment of central nervous system leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Diseases; Child, Preschool; Cytarabine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Injections; Injections, Intraventricular; Leukemia, Lymphoid; Lumbosacral Region; Male; Methotrexate | 1977 |
High-dose methotrexate in acute lymphocytic leukemia.
Topics: Child; Drug Administration Schedule; Humans; Injections, Intravenous; Injections, Spinal; Kinetics; Leukemia, Lymphoid; Methotrexate | 1977 |
[Leukemic meningeal involvement in adults and its treatment].
Topics: Acute Disease; Adult; Age Factors; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Remission, Spontaneous | 1977 |
[Contribution to results of treatment of telecobalt irradiation of the CNS in acute lymphatic leukoses in childhood (author's transl)].
Topics: Central Nervous System Diseases; Child; Cobalt Radioisotopes; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radioisotope Teletherapy | 1977 |
Cytochemical demonstration of dihydrofolate reductase in leukaemia and other haematological diseases.
Topics: Hematologic Diseases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocyte Activation; Lymphocytes; Methotrexate; Multiple Myeloma; Polycythemia Vera; Tetrahydrofolate Dehydrogenase | 1977 |
[Hodgkin's disease during remission of acute lymphoblastic leukemia (author's transl)].
Topics: Child; Cyclophosphamide; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms, Multiple Primary; Remission, Spontaneous; Splenectomy; Vincristine | 1977 |
Adult acute leukemia: frequency of central system involvement in long term survivors.
Topics: Adolescent; Adult; Brain Neoplasms; Cytarabine; Female; Follow-Up Studies; Humans; Leukemia; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Recurrence; Remission, Spontaneous; Time Factors | 1977 |
Methotrexate-induced sudden fatal pulmonary reaction.
Topics: Adolescent; Angioedema; Drug Hypersensitivity; Female; Humans; Leukemia, Lymphoid; Methotrexate; Pneumonia; Pulmonary Edema; Remission, Spontaneous; Respiratory Hypersensitivity | 1977 |
[Therapeutic results and prognostic factors in acute lymphatic leukemia in the adult].
Topics: Adult; Asparaginase; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Time Factors; Vincristine | 1977 |
Treatment and outcome of acute lymphoblastic leukaemia (ALL) in children.
Topics: Asparaginase; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Skull; Vincristine | 1977 |
[Autoregulation of L-asparaginase-induced diabetes mellitus].
Topics: Adult; Asparaginase; Diabetes Mellitus; Humans; Leukemia, Lymphoid; Male; Methotrexate | 1977 |
Some new aspects of modern cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Daunorubicin; Drug Therapy, Combination; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mitosis; Neoplasms; Neuraminidase; Prednisone; Vincristine | 1977 |
Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia.
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Malabsorption Syndromes; Male; Methotrexate; Time Factors; Xylose | 1977 |
[Prevention and treatment of neuroleukemia].
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasm Metastasis; Recurrence; Spinal Cord Neoplasms | 1977 |
Combination chemotherapy for acute lymphoblastic leukaemia in adults.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prednisolone; Remission, Spontaneous; Vincristine | 1978 |
[Influence of remission induction therapy on the further outcome of acute lymphoblastic leukemia in children (author's transl)].
Topics: Brain Diseases; Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Life Expectancy; Mercaptopurine; Methotrexate; Methylprednisolone; Remission, Spontaneous; Vincristine | 1978 |
[Evaluation of hepatic function during maintenance therapy of acute lymphoblastic leukemia remission in children].
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Liver; Liver Function Tests; Mercaptopurine; Methotrexate; Remission, Spontaneous | 1977 |
[Prevention of leukemic meningitis within the framework of the therapy of juvenile acute lymphoblastic leukemia].
Topics: Child; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Meningitis; Methotrexate | 1977 |
[Our experience with the treatment of juvenile acute leukemia].
Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Thioguanine; Vincristine | 1977 |
[A patient with diffuse lung symptoms].
Topics: Adult; Antineoplastic Agents; Female; Humans; Leukemia, Lymphoid; Lung; Methotrexate; Pulmonary Fibrosis | 1978 |
Therapeutic considerations in acute lymphocytic leukemia.
Topics: Antineoplastic Agents; Child; Daunorubicin; Drug Therapy, Combination; Follow-Up Studies; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Recurrence; Remission, Spontaneous; Vincristine | 1978 |
Giant-cell pneumonia caused by measles and methotrexate in childhood leukaemia in remission.
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Measles; Methotrexate; Pulmonary Fibrosis; Remission, Spontaneous | 1978 |
Etiology of pneumonitis in children with leukemia.
Topics: Leukemia, Lymphoid; Methotrexate; Pulmonary Fibrosis | 1978 |
[Intensification of the initial therapy according to the West-Berlin protocol in acute lymphoblastic leukemia: results after 2 1/2 years in Münster (author's transl)].
Topics: Adolescent; Adrenal Cortex Hormones; Asparaginase; Bacterial Infections; Child; Child, Preschool; Colistin; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Skull; Vincristine | 1978 |
[Treatment of ALL in children. Results and side effects with a modification of protocol memphis VII (author's transl)].
Topics: Adolescent; Asparaginase; Chickenpox; Child; Child, Preschool; Cyclophosphamide; Female; Herpes Zoster; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Skull; Vincristine | 1978 |
[Leukoencephalopathy in children with acute lymphocytic leukemia receiving preventive central nervous system therapy (author's transl)].
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Prednisone; Radiotherapy; Vincristine | 1978 |
The Ommaya reservoir: newly recognized complications and recommendations for insertion and use.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Burkitt Lymphoma; Catheters, Indwelling; Humans; Infant; Injections, Intraventricular; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Seeding | 1978 |
Seizures following intrathecal cytosine arabinoside in young children with acute lymphoblastic leukemia.
Topics: Brain Neoplasms; Child, Preschool; Cytarabine; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radiography; Seizures; Seizures, Febrile; Time Factors | 1978 |
Chemoimmunotherapy of acute leukemia in children.
Topics: Adolescent; Antineoplastic Agents; BCG Vaccine; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Time Factors; Vincristine | 1978 |
Refractory acute leukaemia in adults treated with sequential colaspase and high-dose methotrexate.
Topics: Acute Disease; Adolescent; Adult; Aged; Asparaginase; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Remission, Spontaneous | 1978 |
Pyrimethamine in prevention of relapses of meningeal leukemia: report of two cases.
Topics: Central Nervous System; Child; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Pyrimethamine; Recurrence; Remission, Spontaneous | 1978 |
Use of a human lymphoid cell line to evaluate interactions between prednisolone and other chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Clone Cells; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasms, Hormone-Dependent; Prednisolone; Vincristine | 1978 |
Transient, severe periventricular hypodensity after leukemic prophylaxis with cranial irradiation and intrathecal methotrexate.
Topics: Acute Disease; Brain; Brain Diseases; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Time Factors; Tomography, X-Ray Computed | 1978 |
[Acute lymphoblastic leukemia: hope! (author's transl)].
Topics: Adult; Child; Doxorubicin; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Nervous System Diseases; Prednisone; Prognosis | 1978 |
[Long-term remission in the course of lymphoblastic leukemia treated according to the Paris 06 LA66 program].
Topics: Adolescent; Adult; Child; Daunorubicin; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Time Factors; Vincristine | 1978 |
Maintenance therapy of intermittent high-dose methotrexate in acute childhood leukemia--4-year survivals.
Topics: Child; Drug Administration Schedule; Follow-Up Studies; Humans; Leukemia, Lymphoid; Methotrexate | 1978 |
Recurrent childhood lymphocytic leukemia: clinical and cytokinetic studies of cytosine arabinoside and methotrexate for maintenance of second hematologic remission.
Topics: Adolescent; Bone Marrow; Child; Child, Preschool; Cytarabine; Drug Therapy, Combination; Female; Humans; Infant; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Mitosis; Recurrence; Remission, Spontaneous | 1978 |
Methotrexate encephalopathy. A neuropathologic study.
Topics: Brain; Brain Diseases; Child, Preschool; Female; Gliosis; Humans; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Necrosis | 1978 |
[Morbus Hodgkin as a second malignancy in acute lymphoblastic leukaemia (author's transl)].
Topics: Child; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lymph Nodes; Mercaptopurine; Methotrexate; Methylprednisolone; Neck; Neoplasms, Multiple Primary; Remission, Spontaneous; Vincristine | 1979 |
A reappraisal of the results of stopping therapy in childhood leukemia.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Central Nervous System; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Probability; Recurrence; Remission, Spontaneous; Risk; Sex Factors; Testicular Neoplasms; Time Factors | 1979 |
[AAAP therapy for relapse of acute leukemia (author's transl)].
Topics: Adolescent; Adult; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Prednisolone; Recurrence | 1978 |
[Subacute leukoencephalopathy in a child with acute leukemia (author's transl)].
Topics: Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Subacute Sclerosing Panencephalitis | 1978 |
[A case of acute lymphocytic leukemia relapsed with leukemic pleuritis and paraplegia, with special reference to "AAAP"-therapy effect (author's transl)].
Topics: Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Nitrosourea Compounds; Paraplegia; Pleurisy; Prednisolone; Recurrence | 1978 |
Findings in computerized axial tomography after intrathecal methotrexate and radiation.
Topics: Brain; Brain Diseases; Brain Neoplasms; Child; Humans; Injections, Spinal; Leukemia, Lymphoid; Medulloblastoma; Methotrexate; Tomography, X-Ray Computed | 1978 |
[Intracerebral calcifications associated with intrathecal methotrexate therapy in acute lymphocytic leukemia (author's transl)].
Topics: Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Methotrexate | 1979 |
[High dose methotrexate in children with acute lymphocytic leukemia].
Topics: Child; Drug Evaluation; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate | 1979 |
Acute ascending poliomyelomalacia after treatment of acute lymphocytic leukemia.
Topics: Adolescent; Female; Humans; Ischemia; Leukemia, Lymphoid; Methotrexate; Spinal Cord; Spinal Cord Diseases | 1979 |
Dissimilar courses of twins with leukemia.
Topics: Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Recurrence; Remission, Spontaneous; Vincristine | 1977 |
Adriamycin in combination chemotherapy of adult acute lymphoblastic leukemia: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Vincristine | 1977 |
Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood.
Topics: Adolescent; Asparaginase; Bone Marrow; Child; Child, Preschool; Drug Administration Schedule; Drug Hypersensitivity; Drug Synergism; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Metastasis; Remission, Spontaneous | 1979 |
[Side effects and late results of the combined radio- and chemotherapy of the brain in children with acute lymphoblastic leukemia (author's transl)].
Topics: Adolescent; Alopecia; Cerebrospinal Fluid Proteins; Child; Electroencephalography; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radiotherapy Dosage; Skull | 1979 |
Progeny of survivors of acute lymphocytic leukemia.
Topics: Abortion, Spontaneous; Adolescent; Adult; Cyclophosphamide; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Pregnancy; Vincristine | 1979 |
New leukemia in the course of therapy of acute lymphoblastic leukemia.
Topics: Child, Preschool; Female; Humans; Karyotyping; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate; Remission, Spontaneous | 1978 |
[Analytical study on leukoencephalopathy complicated during the course of acute lymphoblastic leukemia in children (author's transl)].
Topics: Child; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate | 1979 |
[Coagulation proteins in cerebrospinal fluid in children with acute lymphoblastic leukemia during conbined induction therapy].
Topics: Blood Coagulation Factors; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine | 1979 |
[Meningeosis leucaemica. Diagnosis and therapy (author's transl)].
Topics: Adolescent; Adult; Aged; Cell Count; Child; Child, Preschool; Female; Hodgkin Disease; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma; Male; Meningeal Neoplasms; Methotrexate; Middle Aged | 1979 |
[Transient cerebral manifestations induced by intrathecal injection of methotrexate].
Topics: Adult; Humans; Injections, Spinal; Ischemic Attack, Transient; Leukemia, Lymphoid; Male; Methotrexate; Remission, Spontaneous | 1979 |
[Acute lymphatic leukaemia in children: re-examination after remission of at least five years (author's transl)].
Topics: Adolescent; Brain Diseases; Calcinosis; Child; Female; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Male; Methotrexate; Time Factors | 1979 |
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous; Spinal Puncture | 1979 |
[Treatment of acute lymphoblastic leukemia in childhood. Epicritical evaluation of 2 therapeutic regimes].
Topics: Antineoplastic Agents; Asparaginase; Child; Daunorubicin; Dexamethasone; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1979 |
Reinduction therapy for adult acute leukemia with adriamycin, vincristine, and prednisone: a Southwest Oncology Group study.
Topics: Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1979 |
Fatal pneumopathy after cytostatic treatment for leukemia in children.
Topics: Antineoplastic Agents; Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lung; Male; Mercaptopurine; Methotrexate; Prognosis; Pulmonary Fibrosis | 1979 |
[Prognostic factors in acute lymphoblastic leukemia in children].
Topics: Cobalt Radioisotopes; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis; Radioisotope Teletherapy | 1979 |
[ZNS complications in children with acute lymphatic leukemia. Computer tomographic studies].
Topics: Adolescent; Brain Abscess; Calcinosis; Cerebral Hemorrhage; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Lymphoma; Methotrexate; Paralysis; Remission, Spontaneous; Seizures; Subacute Sclerosing Panencephalitis; Tomography, X-Ray Computed | 1979 |
[Malabsorption syndrome in the course of treatment with cytostatics of a child in remission from acute leukemia].
Topics: Antineoplastic Agents; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Malabsorption Syndromes; Methotrexate | 1979 |
Unpredictable serum levels after oral methotrexate in children with acute lymphoblastic leukaemia.
Topics: Administration, Oral; Child; Humans; Leukemia, Lymphoid; Methotrexate | 1979 |
Sister chromatid exchange in lymphocytes from patients with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Crossing Over, Genetic; Female; Humans; Infant; Leukemia, Lymphoid; Lymphocytes; Male; Mercaptopurine; Metaphase; Methotrexate; Mitosis; Sister Chromatid Exchange | 1979 |
The effect of cranial irradiation on blood-brain barrier permeability to methotrexate.
Topics: Adolescent; Adult; Blood-Brain Barrier; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Middle Aged | 1979 |
[Treatment of acute childhood leukemia: dosage schedule of 6-mercaptopurine and methotrexate for maintenance of remission (author's transl)].
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate | 1979 |
Computed tomographic findings of the brain in children with acute lymphocytic leukemia after central nervous system prophylaxis without cranial irradiation.
Topics: Adolescent; Brain; Brain Diseases; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Tomography, X-Ray Computed | 1979 |
Acute lymphoblastic leukemia with eosinophilia and basophilia.
Topics: Antineoplastic Agents; Basophils; Central Nervous System Diseases; Child, Preschool; Diagnosis, Differential; Eosinophilia; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytosis; Male; Methotrexate; Recurrence; Remission, Spontaneous | 1979 |
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukemia (ALL).
Topics: Adolescent; Asparaginase; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Risk; Time Factors; Vincristine | 1979 |
Prognostic factors in adult acute lymphoblastic leukemia.
Topics: Adult; Age Factors; Antigens, Neoplasm; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Vincristine | 1979 |
Hepatotoxicity in the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Child; Humans; Leukemia, Lymphoid; Liver Diseases; Liver Function Tests; Mercaptopurine; Methotrexate | 1979 |
Meningeal involvement in leukemias and malignant lymphomas of adults: incidence, course of disease, and treatment for prevention.
Topics: Adult; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma; Meningeal Neoplasms; Methotrexate; Prognosis; Retrospective Studies; Time Factors | 1979 |
Acute respiratory illness in children with acute lymphoblastic leukemia.
Topics: Central Nervous System Diseases; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Pneumonia, Pneumocystis; Pulmonary Fibrosis | 1977 |
[Immunological membrane markers in blasts and lymphocytes of patients with acute leukemia].
Topics: B-Lymphocytes; Binding Sites; Burkitt Lymphoma; Cell Line; Cell Membrane; Endotoxins; Humans; Immunoglobulin D; Immunoglobulin Fc Fragments; Immunoglobulin M; Leukemia; Leukemia, Lymphoid; Methotrexate; T-Lymphocytes | 1977 |
Membrane transport of methotrexate in human lymphoblastoid cells.
Topics: Animals; Antimetabolites; Biological Transport, Active; Cell Line; Cell Membrane; Folic Acid; Humans; Kinetics; Leucovorin; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Temperature | 1978 |
Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors.
Topics: Adolescent; Adult; Antineoplastic Agents; B-Lymphocytes; Brain; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Methylprednisolone; Middle Aged; Prognosis; Remission, Spontaneous; T-Lymphocytes; Vincristine | 1979 |
High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer.
Topics: Adolescent; Adult; Aged; Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma | 1979 |
[Massive dose methotrexate with citrovorum factor rescue: MTX-pharmacokinetics, excretion pattern, and techniques for safety administration (author's transl)].
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Kinetics; Leucovorin; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate | 1979 |
[Ovarian tumor as an unusual manifestation of treated acute lymphoblastic leukemia].
Topics: Child, Preschool; Female; Humans; Leukemia, Lymphoid; Methotrexate; Ovarian Neoplasms; Prednisone; Vincristine | 1979 |
Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia.
Topics: Adolescent; Antineoplastic Agents; Catheters, Indwelling; Central Nervous System Diseases; Cerebral Ventriculography; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Injections, Intraventricular; Leukemia, Lymphoid; Male; Methotrexate | 1979 |
Neuropsychologic follow-up study of children with acute lymphocytic leukemia. A preliminary report.
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Neurologic Examination; Psychological Tests; Radiotherapy; Remission, Spontaneous; Tomography, Emission-Computed | 1979 |
Current treatment of acute leukemia.
Topics: Bone Marrow Transplantation; Child; Cytarabine; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Metastasis; Prednisone; Vincristine | 1978 |
[Treatment of relapses in juvenile acute lymphoblastic leukemia].
Topics: Asparaginase; Blood-Brain Barrier; Blood-Testis Barrier; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Resistance; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Meningoencephalitis; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Vincristine | 1978 |
Engraftment of RH-positive marrow in a recipient with RH antibody.
Topics: Acute Disease; Adult; Blood Group Incompatibility; Bone Marrow Cells; Bone Marrow Transplantation; Cell Survival; Cyclophosphamide; Cytarabine; Graft Survival; Humans; Hydroxyurea; Injections, Spinal; Isoantibodies; Leukemia, Lymphoid; Male; Methotrexate; Patient Isolators; Rh-Hr Blood-Group System | 1977 |
[Simple propositions in the treatment of acute lymphoblastic leukaemia (author's transl)].
Topics: BCG Vaccine; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunotherapy; Injections, Spinal; Leukemia, Lymphoid; Long-Term Care; Lymphocytes; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Mycobacterium bovis; Prednisone; Remission, Spontaneous; Vincristine | 1977 |
Long-term control of central nervous system leukaemia.
Topics: Central Nervous System Diseases; Child; Humans; Leukemia, Lymphoid; Long-Term Care; Methotrexate; Remission, Spontaneous | 1977 |
Analysis of treatment of childhood leukaemia. V. Advantage of reduced chemotherapy during and immediately after cranial irradiation.
Topics: Brain; Child; Child, Preschool; Female; Humans; Infection Control; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous | 1977 |
Intracerebral calcifications in childhood lymphoblastic leukemia. A new iatrogenic disease?
Topics: Brain; Brain Diseases; Calcinosis; Child, Preschool; Humans; Iatrogenic Disease; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Radiotherapy | 1978 |
Influence of cytotoxic agents on the development of lymphoid neoplasms in connective tissue diseases.
Topics: Humans; Leukemia, Lymphoid; Lymphoma; Methotrexate; Mixed Connective Tissue Disease; Psoriasis; Spondylitis, Ankylosing | 1979 |
Bone scintigraphy: Methotrexate associated bone necrosis.
Topics: Child, Preschool; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteonecrosis; Radionuclide Imaging | 1979 |
Computer assisted tomography in methotrexate encephalopathy.
Topics: Acute Disease; Adolescent; Brain; Brain Diseases; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Tomography, X-Ray Computed | 1977 |
Two dimensional view of combination chemotherapy in vitro.
Topics: Cell Line; Cell Survival; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Methotrexate; Prednisolone; Vincristine | 1978 |
Marrow transplantation for the treatment of aplastic anemia and acute leukemia.
Topics: Anemia, Aplastic; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Graft Rejection; Hematopoietic Stem Cells; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Radioisotope Teletherapy; Remission, Spontaneous; Transplantation, Homologous | 1976 |
[Prophylaxis and therapy of neuro-meningeal involvement of acute lymphoblastic leukemia. Case reports and critical review of literature (author's transl)].
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prednisolone | 1975 |
Development of an effective treatment program for childhood acute lymphocytic leukemia: a preliminary report.
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Doxorubicin; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Radiotherapy, High-Energy; Remission, Spontaneous; Vincristine | 1976 |
Adult central nervous system leukemia: incidence and clinicopathologic features.
Topics: Adolescent; Adult; Aged; Blood Platelets; Central Nervous System Diseases; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Middle Aged; Radiotherapy, High-Energy; Remission, Spontaneous | 1976 |
Meningeal relapse after long-term remission in acute childhood lymphocytic leukemia.
Topics: Central Nervous System Diseases; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors | 1976 |
Persisting production of out-of-cycle blasts during methotrexate therapy in acute leukaemia.
Topics: Adult; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Middle Aged; Mitosis | 1976 |
Methotrexate hepatotoxicity in children with leukemia.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Liver; Liver Cirrhosis; Methotrexate; Transaminases | 1977 |
Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy.
Topics: Adolescent; Brain Diseases; Calcinosis; Cytarabine; Humans; Leukemia, Lymphoid; Methotrexate; Radiography; Remission, Spontaneous | 1977 |
The influence of sequential chemotherapy and radiotherapy on mitogen-induced lymphocyte transformation in patients with acute lymphoblastic leukemia.
Topics: Child; Cobalt Radioisotopes; Cytarabine; Drug Therapy, Combination; Humans; Immunity, Cellular; Leukemia, Lymphoid; Leukocyte Count; Lymphocyte Activation; Lymphocytes; Mercaptopurine; Methotrexate; Mitogens; Nitrogen Mustard Compounds; Prednisone; Remission, Spontaneous; Vincristine | 1976 |
Acute lymphoblastic leukemia terminating as histiocytic medullary reticulosis.
Topics: Acute Disease; Adult; Anemia; Autopsy; Bone Marrow; Erythrocytes; Hepatomegaly; Humans; Leukemia, Lymphoid; Lymph Nodes; Lymphatic Diseases; Male; Methotrexate; Phagocytosis; Prednisone; Remission, Spontaneous; Respiratory Insufficiency; Sodium; Splenomegaly; Sulfates; Vincristine | 1975 |
[The effect of antigen migration inhibition in acute lymphoid leukemia in childhood].
Topics: Antigens, Neoplasm; Cell Migration Inhibition; Child; Humans; Immune Sera; Leukemia, Lymphoid; Leukocytes; Mercaptopurine; Methotrexate; Remission, Spontaneous | 1975 |
Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma.
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Meninges; Methotrexate; Radiotherapy; Vincristine | 1975 |
Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and X-rays.
Topics: Administration, Oral; Brain Diseases; Calcinosis; Cerebellum; Cerebral Cortex; Child; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiography; Radiotherapy | 1975 |
The treatment of acute childhood leukemia: predictions for the future based on extrapolations from the past.
Topics: Brain Neoplasms; Drug Therapy, Combination; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Methotrexate; Prognosis; Remission, Spontaneous | 1975 |
Phenolization of bladder in treatment of massive intractable hematuria.
Topics: Adolescent; Cyclophosphamide; Cystitis; Drug Evaluation; Female; Formaldehyde; Hematuria; Humans; Leukemia, Lymphoid; Methotrexate; Phenols; Prednisone; Radiation Injuries; Radiotherapy; Time Factors; Urinary Bladder; Vincristine | 1975 |
Long-term second remissions in acute lymphatic leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Prednisolone; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Treatment of acute lymphoblastic leukemia in childreq with "prophylactic" intrathecal methotrexate and intensive systemic chemotherapy.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Remission, Spontaneous; Time Factors | 1975 |
The mechanism of action of methotrexate in cultured L5178Y leukemia cells.
Topics: Animals; Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Hypoxanthines; Kinetics; Leukemia, Lymphoid; Methotrexate; Mice; Models, Biological; Thymidine; Time Factors | 1975 |
Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders.
Topics: Adolescent; Adult; Antibodies, Viral; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Hepatitis B Antigens; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Multiple Myeloma; Myeloproliferative Disorders; Prednisone; Procarbazine; Vincristine | 1975 |
[Current methods of treatment of acute lymphoblastic leukemia in children].
Topics: Acute Disease; Age Factors; Animals; Antineoplastic Agents; Asparaginase; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mitosis; Neutropenia; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
[Letter: Treatment of children with leukemia in the USA].
Topics: Antineoplastic Agents; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Radiography; United States; Vincristine | 1975 |
[Electroencephalographic and neurological changes in children given intraspinal preventive treatment with amethopterin and methylprednisolone].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Methylprednisolone | 1975 |
Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.
Topics: Adenine; Adenosine Triphosphate; Animals; Cell Line; Cytosine Nucleotides; Depression, Chemical; DNA; Guanine; Guanosine Triphosphate; Hypoxanthines; Leucine; Leukemia, Lymphoid; Methotrexate; Mice; Purines; RNA; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1975 |
Prognosis after acute lymphoblastic leudaemia.
Topics: Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prognosis; Virus Diseases | 1975 |
Acute leukemia in adults: assessment of remission induction with combination chemotherapy by clinical and cell-culture criteria.
Topics: Acute Disease; Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Clone Cells; Culture Media; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Drug Therapy, Combination; Female; Granulocytes; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Cell kinetics and practical consequences for therapy of acute leukemia.
Topics: Adrenal Cortex Hormones; Asparaginase; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Cytarabine; Daunorubicin; DNA; DNA, Neoplasm; Drug Therapy, Combination; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mitosis; Prognosis; Vincristine | 1975 |
[Our recent therapeutic experiences in acute leukemia].
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Prednisone; Vincristine | 1975 |
[Leukemic meningo-encephalopathy. Clinical and therapeutic considerations].
Topics: Acute Disease; Asparaginase; Child; Child, Preschool; Cobalt Isotopes; Cytarabine; Humans; Leukemia, Lymphoid; Meningoencephalitis; Methotrexate; Radioisotope Teletherapy | 1975 |
[Prevention and therapy of leukemic meningeal disease studied in 73 cases].
Topics: Adult; Child; Cobalt Isotopes; Cytarabine; Humans; Leukemia, Lymphoid; Meningitis; Methotrexate; Radioisotope Teletherapy | 1975 |
[2 cases of acute lymphatic leukemia in childhood, with long-term survival].
Topics: Adolescent; Child; Child, Preschool; Cytarabine; Daunorubicin; Evaluation Studies as Topic; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Vincristine | 1975 |
Meningeal localisation of acute leukaemias.
Topics: Cytarabine; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Meninges; Methotrexate; Skull; Spinal Cord | 1975 |
Leukoencephalopathy following combined therapy of central nervous system leukemia and lymphoma.
Topics: Axons; Brain; Brain Diseases; Burkitt Lymphoma; Central Nervous System Diseases; Child; Cytarabine; Humans; Injections, Spinal; Leukemia, Lymphoid; Meninges; Methotrexate; Necrosis; Radiotherapy | 1975 |
Treatment of acute leukemia in adults.
Topics: Adolescent; Adult; Aged; Asparaginase; Carmustine; Child; Cytarabine; Daunorubicin; Female; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Remission, Spontaneous; Thioguanine; Vincristine | 1975 |
[Combined radiotherapy and chemotherapy of the central nervous system in malignant neoplasms of children (author's transl)].
Topics: Adolescent; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Child, Preschool; Craniopharyngioma; Cyclophosphamide; Ependymoma; Female; Humans; Infant; Leukemia, Lymphoid; Male; Medulloblastoma; Methotrexate; Radiotherapy Dosage; Vincristine | 1975 |
[Acute lymphoblastic leukemia after tuberculosis in a 8-year old greek boy with homozygous beta-thalassemia (author's transl)].
Topics: Blood Transfusion; Child; Cyclophosphamide; Drug Therapy, Combination; Germany, West; Greece; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Skull; Thalassemia; Time Factors; Tuberculosis, Pulmonary; Vincristine | 1975 |
Prevention of meningeal leukaemia and relapses by cranial irradiation and intrathecal MTX in acute lymphatic leukaemia.
Topics: Child; Humans; Injections, Spinal; Leukemia, Lymphoid; Meninges; Methotrexate; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous; Skull | 1975 |
Reactivation of scabies rash by methotrexate.
Topics: Adolescent; Benzyl Compounds; Cytarabine; Female; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Scabies; Vincristine | 1975 |
[Time of maintenance therapy in acute lymphatic leukemias of childhood].
Topics: Cell Transformation, Neoplastic; Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors | 1975 |
Intermittent chemotherapy and immunotherapy with BCG in remission maintenance of children with acute lymphocytic leukemia: effects upon immunological function.
Topics: Antibodies, Neoplasm; Antigens, Neoplasm; BCG Vaccine; Bone Marrow Cells; Cell Membrane; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immune Adherence Reaction; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Skin Tests; Vincristine | 1975 |
Non-Hodgkin's lymphoma in children: results of treatment with LSA2-L2 protocol.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Bone Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Lymph Nodes; Lymphoma; Male; Mediastinal Neoplasms; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Skin Neoplasms; Stomach Neoplasms; Thioguanine; Vincristine | 1975 |
Brain damage after intrathecal methotrexate.
Topics: Adolescent; Adult; Aged; Brain Diseases; Cerebral Cortex; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Male; Methotrexate; Middle Aged; Recurrence | 1975 |
Organ irradiation and combination chemotherapy in treatment of acute lymphocytic leukaemia in children.
Topics: Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Infant; Kidney; Leukemia, Lymphoid; Leukocytes; Liver; Male; Mercaptopurine; Methotrexate; Prednisone; Spleen; Vincristine | 1975 |
Immunosuppression and immunostimulation in acute leukaemia.
Topics: Acute Disease; BCG Vaccine; Central Nervous System Diseases; Humans; Immunosuppression Therapy; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Neutropenia | 1975 |
Treatment of acute lymphoblastic leukemia in adolescents and a-dults: A retrospective study of 41 patients (1970-1973).
Topics: Adolescent; Adult; Age Factors; Aged; Daunorubicin; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Retrospective Studies; Sex Factors; Time Factors; Vincristine | 1975 |
Acute lymphoblastic leukaemia: cyclical chemotherapy with three combinations of four drugs (COAP-POMP-CART regimen).
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Blood Cell Count; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisolone; Prognosis; Remission, Spontaneous; Thioguanine; Vincristine | 1975 |
Cure expectancy in children with acute lymphoid leukemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Cytarabine; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prognosis; Vincristine | 1975 |
Chronic neurologic disturbance in childhood leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Learning Disabilities; Leukemia; Leukemia, Lymphoid; Methotrexate; Movement Disorders; Nervous System Diseases; Prospective Studies; Radiotherapy; Seizures; Time Factors | 1976 |
Acute and chronic effects of methotrexate on hepatic, pulmonary, and skeletal systems.
Topics: Bone and Bones; Humans; Leukemia, Lymphoid; Liver; Lung; Methotrexate; Osteoporosis; Pneumonia; Pulmonary Fibrosis; Scoliosis | 1976 |
[Disseminated necrotizing leukoencephalopathy following intrathecal methotrexate in childhood leukemia (author's transl)].
Topics: Brain Diseases; Child; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1976 |
Cerebral calcifications associated with intrathecal methotrexate therapy in acute lymphocytic leukemia.
Topics: Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1976 |
["Preventive" cranial irradiation in acute lymphoblastic leukemia in childhood].
Topics: Acute Disease; Adolescent; Age Factors; Alopecia; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Premedication; Prognosis; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous; Skull; Vincristine | 1976 |
Factors that influence haematological remission duration in acute lymphocytic leukaemia.
Topics: Child; Child, Preschool; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Time Factors; Vincristine; X-Rays | 1976 |
Acute lymphoblastic leukemia in adults and children. Differences in response with similar therapeutic regimens.
Topics: Adolescent; Adult; Age Factors; Aged; Asparaginase; Brain Neoplasms; Carmustine; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Spinal Neoplasms; Thioguanine; Vincristine | 1976 |
Treatment of acute lymphocytic leukemia by high-dose intravenous methotrexate.
Topics: Brain Neoplasms; Infusions, Parenteral; Leukemia, Lymphoid; Methotrexate; Neoplasm Metastasis | 1976 |
Relationship between intracellular dihydrofolate reductase and tightly bound intracellular methotrexate in human neoplastic cells.
Topics: Burkitt Lymphoma; Cells, Cultured; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase; Time Factors | 1976 |
Results of therapy in adult acute lymphocytic leukemia.
Topics: Adolescent; Adult; Central Nervous System; Daunorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Vincristine | 1975 |
Letter: Vasculitis as a complication of high-dose methotrexate in the treatment of acute leukemia.
Topics: Child, Preschool; Female; Humans; Leukemia, Lymphoid; Methotrexate; Vascular Diseases | 1976 |
[High dosage of Methotrexate in childhood malignancy].
Topics: Child, Preschool; Dose-Response Relationship, Drug; Humans; Kidney Neoplasms; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Metastasis | 1976 |
Multiple-drug chemotherapy in the management of acute lymphocytic leukemia during pregnancy.
Topics: Adolescent; Cyclophosphamide; Delivery, Obstetric; Drug Therapy, Combination; Female; Humans; Labor, Induced; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Pregnancy; Pregnancy Complications, Hematologic; Vincristine | 1976 |
[Acute lymphoblastic leukemia: treatment results in 27 children (author's transl)].
Topics: Child; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Meningitis; Methotrexate; Remission, Spontaneous | 1976 |
[Duration of chemotherapy in acute lymphoblastic leukemia of childhood (author's transl)].
Topics: Child; Child, Preschool; Drug Administration Schedule; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Recurrence | 1976 |
[Pulmonary disease during mtx therapy in a.l.l. (author's transl)].
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Methotrexate; Pneumonia; Radiography | 1976 |
[Acute juvenile lymphatic leukemia in the Netherlands: study ALL II, 1973-5; Foundation Dutch Childhood Leukemia Study Group].
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Netherlands; Prednisolone; Prednisone; Vincristine | 1976 |
[Prevention of meningeal leukosis].
Topics: Antineoplastic Agents; Cobalt Radioisotopes; Humans; Injections, Spinal; Leukemia, Lymphoid; Meningitis; Methotrexate | 1976 |
[Rare complications in the course of leukemia on the central nervous system].
Topics: Acute Disease; Adolescent; Blood-Brain Barrier; Brain; Child; Female; Humans; Intraocular Pressure; Leukemia, Lymphoid; Male; Methotrexate; Optic Atrophy | 1976 |
Acute leukemia in adults: comparison of survival between a treated and an untreated group.
Topics: Acute Disease; Adolescent; Adult; Aged; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Thioguanine; Thioinosine; Vincristine | 1976 |
IMFRA (intermittent intrathecal methotrexate and fractional radiation) plus chemotherapy in childhood leukemia.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Radiation; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Remission, Spontaneous | 1976 |
Chemotherapy of acute lymphoblastic leukemia in children.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Nitrosourea Compounds; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1976 |
Bilateral interstitial pneumonia in acute lymphoblastic leukemia.
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Pulmonary Fibrosis; Remission, Spontaneous; Retrospective Studies | 1976 |
In vitro correlates of clinical response to methotrexate in actue leukaemia and Burkitt's lymphoma.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Burkitt Lymphoma; Cells, Cultured; Child; Child, Preschool; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate | 1976 |
Immunocompetence and prognosis in children with acute lymphoblastic leukemia: combination of two different maintenance therapies.
Topics: Acute Disease; Adolescent; Antibody Formation; Child; Child, Preschool; Female; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prognosis | 1976 |
Osteopathy due to methotrexate.
Topics: Calcium; Child; Femoral Fractures; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteoporosis; Phosphates | 1976 |
Trends in the treatment of childhood leukemia.
Topics: Cerebrospinal Fluid; Child; Cyclophosphamide; Dose-Response Relationship, Radiation; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1976 |
Immunological follow-up of acute lymphoblastic leukaemia.
Topics: Antibody Formation; Child; Cyclophosphamide; Cytarabine; Female; Follow-Up Studies; Humans; Immunity, Cellular; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leukemia, Lymphoid; Leukocyte Count; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Prednisolone; Skin Tests | 1976 |
Treatment of acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; Asparaginase; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1976 |
L-asparaginase therapy and its complications in acute lymphoid leukaemia and generalized lymphosarcoma.
Topics: Adolescent; Anaphylaxis; Asparaginase; Child; Child, Preschool; Confusion; Daunorubicin; Female; Hallucinations; Hemorrhage; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Pancreatitis; Prednisolone; Retroperitoneal Space; Vinblastine; Vincristine | 1976 |
Complications of intrathecal methotrexate prophylaxis and treatment of central nervous system leukemia in children.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1976 |
Studies on the transport and distribution of diaminopyrimidines in L5178Y lymphoblasts in cell culture.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line; Chlorobenzenes; Diamines; Kinetics; Leucovorin; Leukemia, Lymphoid; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1975 |
Acute lymphocytic leukemia in children.
Topics: Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Pneumonia, Pneumocystis; Remission, Spontaneous | 1975 |
Influence of prednisone and cytostatics on human blood B-, T- and O-lymphocytes in diseases.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Azathioprine; B-Lymphocytes; Child; Chlorambucil; Collagen Diseases; Cyclophosphamide; Depression, Chemical; Drug Combinations; Female; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Methotrexate; Middle Aged; Prednisone; Psoriasis; T-Lymphocytes | 1975 |
Impaired responsiveness to folinic acid protection in methotrexate-resistant L5178Y cells.
Topics: Biological Transport; Cell Line; Cell Survival; Drug Resistance; Leucovorin; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Pyrimethamine | 1975 |
Methotrexate resistance and uptake of DDMP by L5178Y cells. Selective protection with folinic acid.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line; Chlorobenzenes; Drug Resistance; Kinetics; Leucovorin; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Mice; Pyrimidines; Temperature | 1975 |
Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Deoxyuridine; DNA; Drug Administration Schedule; Female; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Thymine | 1976 |
Influence of different cytotoxic drugs on T and B lymphocytes in children with all during remission maintenance therapy.
Topics: Adolescent; Antineoplastic Agents; B-Lymphocytes; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Mercaptopurine; Methotrexate; Remission, Spontaneous; T-Lymphocytes | 1976 |
The central nervous system in childhood leukemia. II. Subacute leukoencephalopathy.
Topics: Adolescent; Age Factors; Autopsy; Brain; Brain Neoplasms; Child; Child, Preschool; Escherichia coli Infections; Female; Humans; Infant; Injections, Intravenous; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Nutrition Disorders; Radiotherapy; Radiotherapy Dosage | 1975 |
Adverse effects of intrathecal methotrexate in children with acute leukemia in remission.
Topics: Adolescent; Carbohydrates; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Humans; Indicator Dilution Techniques; Injections, Spinal; Leukemia, Lymphoid; Lymphocytes; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Monocytes; Neutrophils; Osmolar Concentration; Radiation Effects; Remission, Spontaneous; Skull | 1975 |
[Letter: Meningeal lymphocyte infiltration in chronic lymphoid leukemia].
Topics: Aged; Humans; Leukemia, Lymphoid; Lymphocytosis; Male; Methotrexate | 1976 |
Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate; Phosphoribosyl Pyrophosphate; Trimetrexate; Tumor Cells, Cultured | 1992 |
[Preparation and cytotoxicity of McAb-HSA-MTX conjugates].
Topics: Albumins; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cytotoxicity Tests, Immunologic; Humans; Immunotoxins; Leukemia, Lymphoid; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1990 |
Myelin basic protein concentrations in the CSF of children receiving methotrexate.
Topics: Child; Humans; Leukemia, Lymphoid; Methotrexate; Myelin Basic Protein | 1986 |
Cerebrospinal fluid biogenic amine metabolites in children during treatment for acute lymphocytic leukemia.
Topics: Adolescent; Adult; Biogenic Amines; Child; Child, Preschool; Cytarabine; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Serotonin; Time Factors | 1986 |
Myelin basic protein in CSF of children receiving intrathecal chemotherapy.
Topics: Child; False Negative Reactions; Humans; Leukemia, Lymphoid; Methotrexate; Myelin Basic Protein; Paraplegia | 1986 |
Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
Topics: Aminoimidazole Carboxamide; Cell Line; Drug Synergism; Glutamine; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; T-Lymphocytes | 1986 |
Dose-related effects of methotrexate on purine and pyrimidine nucleotides and on cell-kinetic parameters in MOLT-4 malignant human T-lymphoblasts.
Topics: Cell Division; Cell Line; Cell Survival; DNA Replication; Humans; Leukemia, Lymphoid; Methotrexate; Purine Nucleotides; Pyrimidine Nucleotides; RNA; T-Lymphocytes; Time Factors | 1986 |
[Changes in the blood-cerebrospinal fluid barrier for serum proteins in children with acute lymphatic leukemia].
Topics: Adolescent; alpha-Macroglobulins; Blood Proteins; Blood-Brain Barrier; Child; Child, Preschool; Combined Modality Therapy; Humans; Immunoglobulin G; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Serum Albumin | 1987 |
Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Cell Line; Chromatography, High Pressure Liquid; Humans; Kinetics; Leukemia, Lymphoid; Liver; Male; Methotrexate; Polyglutamic Acid; Rabbits; T-Lymphocytes | 1987 |
Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia.
Topics: Adult; alpha 1-Antitrypsin; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Liver Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Proteins; Neoplasms, Multiple Primary | 1987 |
Methotrexate polyglutamate synthesis in lymphoblasts from children with acute lymphoblastic leukemia.
Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Female; Humans; In Vitro Techniques; Leukemia, Lymphoid; Lymphocytes; Male; Methotrexate; Peptides; Polyglutamic Acid | 1987 |
In vivo decline of methotrexate and methotrexate polyglutamates in age-fractionated erythrocytes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocyte Aging; Erythrocyte Count; Erythrocytes; Humans; Leukemia, Lymphoid; Mathematics; Mercaptopurine; Methotrexate; Peptides; Polyglutamic Acid; Regression Analysis; Reticulocytes | 1988 |
Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocyte Aging; Erythrocytes; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Peptides; Polyglutamic Acid | 1988 |
Ascending myelopathy after chemotherapy for central nervous system acute lymphoblastic leukemia: correlation with cerebrospinal fluid myelin basic protein.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Myelin Basic Protein; Prednisone; Radiotherapy Dosage; Recurrence; Spinal Cord Neoplasms; Testicular Neoplasms; Vincristine | 1985 |
Severe anemia caused by human parvovirus in a leukemia patient on maintenance chemotherapy.
Topics: Anemia, Aplastic; Antineoplastic Agents; Child; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Parvoviridae Infections; Prednisone; Vincristine | 1988 |
Progression of a human B cell chronic lymphocytic leukemia line in nude mice.
Topics: Animals; B-Lymphocytes; Cell Division; Cell Transformation, Viral; Chlorambucil; Chronic Disease; Freeze Fracturing; Herpesvirus 4, Human; Humans; Karyotyping; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Nude; Microscopy, Electron; Tumor Cells, Cultured | 1988 |
Maintenance chemotherapy for childhood acute lymphoblastic leukaemia: better in the evening.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Time Factors | 1985 |
Timing of maintenance chemotherapy for childhood acute lymphoblastic leukaemia.
Topics: Animals; Child; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Seasons | 1986 |
Excessive chemotherapy-related myelotoxicity in children with Down syndrome and acute lymphoblastic leukaemia.
Topics: Adolescent; Agranulocytosis; Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Down Syndrome; Humans; Leukemia, Lymphoid; Methotrexate; Neutropenia | 1986 |
Toxicity of leukaemia therapy in children with Down syndrome.
Topics: Bone Marrow; Child; Down Syndrome; Humans; Leukemia, Lymphoid; Methotrexate; Mouth Diseases; Ulcer | 1986 |
Folate requirements of methotrexate-resistant human acute lymphoblastic leukemia cell lines.
Topics: Biological Transport; Cell Line; Drug Resistance; Folic Acid; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Nutritional Requirements; Quinazolines; Trimetrexate | 1986 |
Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Doxorubicin; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neprilysin; Prednisone; Prognosis; Prospective Studies; Risk; Vincristine | 1986 |
Bone marrow transplantation as treatment of hematologic disease.
Topics: Acute Disease; Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Child; Combined Modality Therapy; Female; Graft vs Host Disease; Hematologic Diseases; HLA Antigens; Humans; Infections; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Culture Test, Mixed; Methotrexate; Tissue Donors; Whole-Body Irradiation | 1986 |
Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate | 1987 |
Studies of methotrexate-monoclonal antibody conjugates for immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Line; Cell Transformation, Viral; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Esterification; Herpesvirus 4, Human; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms; Receptors, Cell Surface; Receptors, Transferrin; Rosette Formation | 1985 |
Astrocytoma as a second malignancy in patients with acute lymphoblastic leukemia.
Topics: Adult; Astrocytoma; Brain Neoplasms; Child; Female; Glioblastoma; Humans; Leukemia, Lymphoid; Male; Methotrexate; Neoplasms, Multiple Primary; Spinal Cord Neoplasms; Time Factors | 1986 |
Bone-marrow transplantation for haematological malignancy in childhood.
Topics: Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytomegalovirus Infections; Evaluation Studies as Topic; Female; Graft vs Host Disease; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Lymphatic Diseases; Male; Methotrexate; Pneumonia; Premedication; Prognosis; Recurrence; Time Factors; Transplantation, Homologous; Whole-Body Irradiation | 1986 |
Allogeneic bone marrow transplantation in children: Tokai experience 1982 to 1984.
Topics: Acute Disease; Acyclovir; Adolescent; Anemia, Aplastic; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Female; Graft vs Host Disease; Herpesviridae Infections; Humans; Immunologic Deficiency Syndromes; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Male; Methotrexate; Transplantation, Homologous | 1985 |
Leukaemic meningitis in chronic lymphocytic leukaemia.
Topics: Humans; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Meningitis; Methotrexate; Middle Aged | 1986 |
Methotrexate, folate and the brain.
Topics: Administration, Oral; Animals; Brain; Child; Folic Acid; Folic Acid Antagonists; Haplorhini; Homeostasis; Humans; Injections, Intramuscular; Leukemia, Lymphoid; Male; Methotrexate; Oxidation-Reduction; Rats | 1986 |
[Chemotherapy of medium-to-large doses in the treatment of acute leukemia: report of 16 cases].
Topics: Adolescent; Adult; Cytarabine; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged | 1987 |
Physician compliance and relapse rates of acute lymphoblastic leukemia in children.
Topics: Administration, Oral; Brain Neoplasms; Child; Humans; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Practice Patterns, Physicians'; Radiotherapy Dosage; Remission Induction | 1988 |
Home care involving methotrexate infusions for children with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Home Nursing; Humans; Infusions, Intravenous; Leukemia, Lymphoid; Methotrexate | 1988 |
Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia.
Topics: Bicarbonates; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Leukemia, Lymphoid; Methotrexate | 1988 |
Altered phenytoin clearance during intensive chemotherapy for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Epilepsy; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Metabolic Clearance Rate; Methotrexate; Phenytoin; Prednisone; Vincristine | 1988 |
Acute lymphoblastic leukemia in adults: results of intraventricular maintenance chemotherapy for central nervous system prophylaxis and treatment.
Topics: Adolescent; Adult; Aged; Female; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Remission Induction | 1988 |
Clinical use of intermediate to high dose of N4-behenoyl-1-beta-D-arabinofuranosylcytosine in children with acute leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Daunorubicin; Half-Life; Humans; Hydrocortisone; Leukemia, Lymphoid; Methotrexate | 1988 |
Methotrexate leukoencephalopathy mimicking cerebral abscess on CT brain scan.
Topics: Brain Abscess; Brain Diseases; Child; Diagnosis, Differential; Female; Humans; Leukemia, Lymphoid; Methotrexate; Tomography, X-Ray Computed | 1988 |
[Prophylactic central nervous system therapy in childhood leukemia and its complications].
Topics: Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Prognosis | 1988 |
[Meningiosis neoplastica--clinical aspects and therapy. Experiences in 78 cases].
Topics: Breast Neoplasms; Combined Modality Therapy; Follow-Up Studies; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Melanoma; Meningeal Neoplasms; Meninges; Methotrexate; Skin Neoplasms | 1988 |
Central nervous system prophylaxis in childhood acute lymphoblastic leukaemia: CT brain appearance after 3 years continuous complete remission in 36 Malaysian children.
Topics: Brain; Child; Child, Preschool; Combined Modality Therapy; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Remission Induction; Tomography, X-Ray Computed | 1988 |
[Large doses of cytarabine, etoposide and methotrexate (CEM protocol) in the treatment of lymphoblastic leukemia in adults, resistant to conventional treatment, and of recurrences].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged | 1988 |
[Extramedullary localization of acute leukemia. I. The involvement of the central nervous system].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Combined Modality Therapy; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Radiotherapy Dosage | 1988 |
Synthesis and biological properties of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Line; Folic Acid Antagonists; Humans; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Tetrahydrofolates | 1988 |
Leukemia in the central nervous system.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Middle Aged | 1988 |
Paraplegia and quadriplegia after intrathecal chemotherapy.
Topics: Adult; Child; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Paraplegia; Quadriplegia; Rhabdomyosarcoma | 1988 |
Methotrexate administered by 6-h and 24-h infusion: a pharmacokinetic comparison.
Topics: Child; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Osteosarcoma | 1988 |
Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation.
Topics: Acute Disease; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Cyclosporins; Female; Graft vs Host Disease; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate; Regression Analysis; Risk Factors | 1988 |
Treatment of 218 adult acute lymphoblastic leukemias.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisone; Vincristine | 1987 |
Cytosine arabinoside for induction, salvage, and consolidation therapy of adult acute lymphoblastic leukemia.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisone; Thioguanine; Vincristine | 1987 |
Clonogenic hemopoietic precursors in bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Transplantation; Cells, Cultured; Clone Cells; Colony-Forming Units Assay; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Transplantation, Homologous | 1987 |
Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Synergism; Humans; Leukemia, Lymphoid; Methotrexate; Time Factors; Tumor Cells, Cultured; Vincristine | 1988 |
Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis therapy for leukemia.
Topics: Brain; Brain Neoplasms; Child; Child, Preschool; Cognition; Combined Modality Therapy; Humans; Injections, Spinal; Intelligence Tests; Leukemia, Lymphoid; Magnetic Resonance Imaging; Male; Methotrexate | 1988 |
Cyclic combination chemotherapy for acute lymphoblastic leukemia recurring after elective cessation of therapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Vincristine | 1988 |
[Clinical effect of prostaglandin E1 on liver dysfunction due to high-dose methotrexate].
Topics: Alprostadil; Bone Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Osteosarcoma | 1988 |
Sequential testicular biopsies in childhood acute lymphocytic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Prednisone; Prognosis; Prospective Studies; Testicular Neoplasms; Testis; Vincristine | 1986 |
Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment.
Topics: Absorption; Administration, Oral; Child; Child, Preschool; Erythrocytes; Female; Half-Life; Humans; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Time Factors | 1986 |
[Prognostic significance of systemic clearance of methotrexate in acute lymphoid leukemia in childhood].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Sex Factors | 1986 |
Modified Capizzi maintenance regimen in children with relapsed acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Methotrexate; Recurrence; Vincristine | 1986 |
The pharmacology of orally administered chemotherapy. A reappraisal.
Topics: Administration, Oral; Allopurinol; Biological Availability; Child; Circadian Rhythm; Drug Administration Schedule; Drug Interactions; Food; Humans; Infusions, Parenteral; Kinetics; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Recurrence | 1986 |
Treatment of refractory acute lymphoblastic leukemia with teniposide and cytarabine.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Cytarabine; Humans; Leukemia, Lymphoid; Methotrexate; Teniposide | 1986 |
Systemic high-dose ara-C for the treatment of meningeal leukemia in adult acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Cytarabine; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Meningeal Neoplasms; Methotrexate; Middle Aged | 1986 |
[Serum and cerebrospinal fluid levels in systemic medium-high and high dosage methotrexate therapy in pediatric neuro-oncology].
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia, Lymphoid; Medulloblastoma; Meningeal Neoplasms; Methotrexate | 1986 |
Hemostatic changes in children with acute lymphoblastic leukemia treated according to two different L-asparaginase schedules.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Antithrombins; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Female; Fibrinogen; Hemostasis; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Partial Thromboplastin Time; Platelet Count; Prednisone; Prospective Studies; Prothrombin Time; Reference Values; Thrombin Time; Vincristine | 1986 |
Detection of the chromosomally abnormal clone in acute lymphoblastic leukemia.
Topics: Bone Marrow; Child; Child, Preschool; Chromosome Aberrations; Clone Cells; Humans; Karyotyping; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Ploidies | 1986 |
Prognostic relevance of clinical pharmacology of antileukemic drugs.
Topics: Antineoplastic Agents; Biological Availability; Dose-Response Relationship, Drug; Humans; Individuality; Intestinal Absorption; Kinetics; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Patient Compliance; Prognosis | 1986 |
Early results of intensified remission induction chemotherapy for childhood acute lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Digestive System; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis; Risk; Seizures | 1986 |
Methotrexate infusions in poor prognosis acute lymphoblastic leukemia: II. High-dose methotrexate (HDM) in acute lymphoblastic leukemia in childhood: a pilot study from April 1981.
Topics: Child; Child, Preschool; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Methotrexate; Pilot Projects; Time Factors | 1986 |
Methotrexate infusions in poor prognosis acute lymphoblastic leukemia in children: I. The Norwegian methotrexate study in acute lymphoblastic leukemia in childhood, August 1975-December 1980.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Methotrexate; Time Factors | 1986 |
Therapy of refractory adult acute lymphoblastic leukemia with vincristine and prednisone plus tandem methotrexate and L-asparaginase. Results of a Cancer and Leukemia Group B Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Female; Hematopoiesis; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Pneumonia; Prednisone; Stomatitis; Vincristine | 1986 |
Acute lymphoblastic leukaemia under 2 years.
Topics: Adolescent; Age Factors; Child; Child, Preschool; England; Female; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Nervous System Diseases; Prognosis; Radiotherapy | 1986 |
[New aspects of the determination of blood methotrexate levels in leukemic children].
Topics: Blood-Brain Barrier; Child; Humans; Infusions, Intravenous; Leukemia, Lymphoid; Metabolic Clearance Rate; Methotrexate; Prognosis | 1986 |
[End results and comparative analysis of treatment programs for childhood acute lymphocytic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Combined Modality Therapy; Humans; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Prognosis | 1987 |
Methotrexate pharmacokinetics in age-fractionated erythrocytes.
Topics: Chemical Fractionation; Erythrocyte Aging; Erythrocyte Count; Erythrocytes; Humans; Infusions, Parenteral; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Reticulocytes | 1986 |
[Children with acute lymphatic leukemia. Long-term prognosis and a follow-up of a national sample treated with methotrexate].
Topics: Child; Child, Preschool; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Methotrexate; Norway; Prognosis | 1986 |
Studies on the assessment of neurotoxicity in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Brain; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Electroencephalography; Evoked Potentials, Auditory; Evoked Potentials, Visual; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1987 |
[Clinical pharmacology of methotrexate (MTX)--altered central nervous system pharmacology of MTX with meningial relapse of childhood leukemia].
Topics: Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Kinetics; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate | 1986 |
[Intellectual dysfunction in long-term survivor of one of identical twin with acute lymphocytic leukemia. Children's Cancer and Leukemia Study Group].
Topics: Child; Diseases in Twins; Female; Humans; Intellectual Disability; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Radiotherapy; Twins, Monozygotic | 1986 |
[Transient cerebral dysfunction induced by VCR, HD-MTX in a child with acute lymphocytic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Drug Administration Schedule; Electroencephalography; Humans; Leukemia, Lymphoid; Male; Methotrexate; Seizures; Vincristine | 1986 |
Pharmacokinetics and toxicity of frequent intermediate dose methotrexate infusions.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1986 |
The effect of methotrexate on the bioavailability of oral 6-mercaptopurine.
Topics: Administration, Oral; Adolescent; Biological Availability; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate | 1987 |
Evolution of acute lymphoblastic leukemia in mice treated with carrier-bound methotrexate and levamisole.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Leukemia, Lymphoid; Levamisole; Methotrexate; Mice; Mice, Inbred Strains; Serum Albumin, Bovine | 1987 |
The problem of preventing testicular leukaemia.
Topics: Child; Humans; Leukemia, Lymphoid; Male; Methotrexate; Testicular Neoplasms | 1987 |
Cerebellar sclerosis in pediatric cancer patients.
Topics: Cerebellum; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Retrospective Studies; Sclerosis | 1987 |
In vitro effectiveness of a mistletoe preparation on cytostatic-drug-resistant human leukemia cells.
Topics: Cell Line; Cell Survival; Drug Resistance; Humans; Leukemia, Lymphoid; Methotrexate; Mistletoe; Plant Extracts; Plants, Medicinal | 1987 |
A comparative study on the pharmacokinetics of methotrexate in a dose range of 0.5 g to 33.6 g/m2 in children with acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Age Factors; Child; Child, Preschool; Drug Administration Schedule; Half-Life; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Kinetics; Leukemia, Lymphoid; Mathematics; Metabolic Clearance Rate; Methotrexate | 1987 |
Prognostic importance of systemic clearance of methotrexate in childhood acute lymphoblastic leukemia.
Topics: Child; Drug Administration Schedule; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; Remission Induction | 1987 |
Toxicity of conventional ALL chemotherapy: incidence of short-term adverse effects in 100 children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Vincristine | 1987 |
Effects of local irradiation and i.v. methotrexate on brain morphology in rabbits: early changes.
Topics: Animals; Astrocytes; Brain; Cerebrovascular Circulation; Combined Modality Therapy; Leukemia, Lymphoid; Methotrexate; Myelin Sheath; Oligodendroglia; Rabbits | 1987 |
Intellectual and academic achievement status after CNS relapse: a retrospective analysis of 40 children treated for acute lymphoblastic leukemia.
Topics: Achievement; Acute Disease; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Intelligence Tests; Leukemia, Lymphoid; Male; Methotrexate; Retrospective Studies; Tomography, X-Ray Computed | 1987 |
Methotrexate in neutrophils in children with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Separation; Child; Drug Administration Schedule; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Neutropenia; Neutrophils; Statistics as Topic | 1987 |
Teniposide plus cytarabine improves outcome in childhood acute lymphoblastic leukemia presenting with a leukocyte count greater than or equal to 100 x 10(9)/L.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Prednisone; Remission Induction; Teniposide; Vincristine | 1987 |
Late multifocal gliomas in adolescents previously treated for acute lymphoblastic leukemia.
Topics: Adolescent; Brain Neoplasms; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Tomography, X-Ray Computed; Vincristine | 1987 |
Pharmacokinetics of oral methotrexate in bone marrow during maintenance treatment of childhood acute lymphocytic leukemia.
Topics: Administration, Oral; Bone Marrow; Child; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1987 |
Early intensification therapy in high-risk childhood acute lymphocytic leukemia: lack of benefit from high-dose methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis; Remission Induction; Risk; Time Factors | 1987 |
[Studies on the initial features and prognosis in 21 infants with acute lymphoblastic leukemia. Children's Cancer and Leukemia Study Group].
Topics: Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prognosis | 1987 |
Transport of folate compounds by leukemic cells. Evidence for a single influx carrier for methotrexate, 5-methyltetrahydrofolate, and folate in CCRF-CEM human lymphoblasts.
Topics: Biological Transport; Buffers; Cell Line; Folic Acid; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Phthalic Acids; Tetrahydrofolates | 1987 |
Effect of dose and repeat intravenous 24 hr infusions of methotrexate on cerebrospinal fluid availability in children with hematological malignancies.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Kinetics; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Methotrexate | 1987 |
[Intrathecal methotrexate--overdosing in pediatric lymphoblastic leukemia].
Topics: Brain Diseases; Child, Preschool; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1987 |
Intracerebral calcification in a child.
Topics: Brain Diseases; Calcinosis; Child; Humans; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy; Tomography, X-Ray Computed | 1987 |
Systemic clearance of methotrexate in the prognosis of acute lymphoblastic leukemia in children.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prognosis | 1987 |
Dihydrofolate reductase-activity in brain tissue. Effect of X-irradiation.
Topics: Animals; Brain; Folic Acid Antagonists; Humans; Leukemia, Lymphoid; Liver; Meningeal Neoplasms; Methotrexate; Rabbits; Tetrahydrofolate Dehydrogenase | 1987 |
The eye in acute leukaemia. 2. The management of solitary anterior chamber relapse.
Topics: Anterior Chamber; Bone Neoplasms; Child; Combined Modality Therapy; Eye Neoplasms; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasm Recurrence, Local | 1987 |
Concurrent analysis of methotrexate, trimethoprim, sulphamethoxazole and their major metabolites in plasma by high-performance liquid chromatography.
Topics: Child; Chromatography, High Pressure Liquid; Humans; Leukemia, Lymphoid; Methotrexate; Spectrophotometry, Ultraviolet; Sulfamethoxazole; Trimethoprim | 1987 |
[Acute lymphoblastic leukemia of high risk: results of a therapeutic protocol].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Prognosis; Risk Factors; Teniposide; Vincristine | 1987 |
[The treatment and neurological complications in the children with acute lymphoblastic leukemia].
Topics: Central Nervous System Diseases; Child; Electroencephalography; Evoked Potentials, Visual; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prospective Studies; Risk Factors | 1987 |
Effect of the intermittent prophylactic treatment of the central nervous system in adults with acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Brain Neoplasms; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Prednisolone; Time Factors | 1987 |
[Consolidating chemotherapy in the treatment program of acute lymphoblastic leukemia in children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Prednisolone; Prognosis; Time Factors; Vincristine | 1986 |
[Alteration of cerebral glucose metabolism after high-dose methotrexate treatment].
Topics: Adolescent; Brain; Child; Female; Glucose; Humans; Leukemia, Lymphoid; Male; Methotrexate; Tomography, Emission-Computed | 1986 |
Results of treatment of advanced-stage Burkitt's lymphoma and B cell (SIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine.
Topics: Actuarial Analysis; Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Staging | 1986 |
The risks of central nervous system relapse and leukoencephalopathy in patients receiving marrow transplants for acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Brain Diseases; Child; Child, Preschool; Humans; Infant; Leukemia; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Middle Aged; Recurrence; Risk | 1986 |
Allogeneic bone marrow transplantation at Christchurch 1979-1985.
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Female; Follow-Up Studies; Graft Rejection; Graft vs Host Disease; Histocompatibility Testing; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Premedication; Retrospective Studies; Transplantation, Homologous | 1986 |
Chronic lymphocytic leukemic meningitis as a cause of the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Inappropriate ADH Syndrome; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Meningitis; Methotrexate | 1987 |
Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells.
Topics: Base Sequence; Cell Division; Cell Line; Drug Resistance; Genes; Humans; Karyotyping; Leukemia, Lymphoid; Methotrexate; Nucleic Acid Hybridization; Tetrahydrofolate Dehydrogenase | 1985 |
Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1985 |
Altered central nervous system pharmacology of methotrexate in childhood leukemia: another sign of meningeal relapse.
Topics: Child; Child, Preschool; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Prognosis; Regression Analysis | 1985 |
Treatment of ocular leukemia with local chemotherapy.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Conjunctiva; Cytarabine; Eye Neoplasms; Female; Humans; Injections; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate | 1985 |
Long-term relapse-free survival in adult acute lymphoblastic leukemia.
Topics: Actuarial Analysis; Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Combined Modality Therapy; Doxorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Nervous System Neoplasms; Prednisone; Prognosis; Recurrence; Vincristine | 1985 |
Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation.
Topics: Acute Disease; Blood Proteins; Blood-Brain Barrier; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Models, Biological | 1985 |
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Drug Resistance; Humans; Leukemia, Lymphoid; Methotrexate; Tetrahydrofolate Dehydrogenase | 1985 |
Remission induction of meningeal leukemia with high-dose intravenous methotrexate.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Methotrexate; Neutropenia; Seizures; Stomatitis | 1985 |
Effect of methotrexate on the immune response in children with acute lymphatic leukaemia.
Topics: Age Factors; Antibodies, Monoclonal; Child; Child, Preschool; Female; Humans; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Mitogens | 1985 |
Small intestinal transit time affects methotrexate absorption in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Female; Gastrointestinal Motility; Humans; Intestinal Absorption; Intestine, Small; Leukemia, Lymphoid; Male; Methotrexate; Time Factors | 1985 |
Central nervous system morbidity following an initial isolated central nervous system relapse and its subsequent therapy in childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Central Nervous System Diseases; Child; Combined Modality Therapy; Humans; Intelligence Tests; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Radiography; Recurrence | 1985 |
Long-term neuropsychologic sequelae of childhood leukemia: correlation with CT brain scan abnormalities.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Communication Disorders; Cytarabine; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Neuropsychological Tests; Prednisone; Tomography, X-Ray Computed; Vincristine | 1985 |
Complications of chemotherapy.
Topics: Central Nervous System; Child, Preschool; Encephalomyelitis; Female; Humans; Leukemia, Lymphoid; Meningoencephalitis; Methotrexate | 1985 |
Risk groups in a multicenter pilot study for treatment of acute lymphoblastic and acute undifferentiated leukemia in adults.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Risk; Thioguanine; Vincristine | 1985 |
The feasibility of opal/high dose Ara-C treatment of adult acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parenteral; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone | 1985 |
Therapy of CNS leukemia with intraventricular chemotherapy and low-dose neuraxis radiotherapy.
Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Injections, Intraventricular; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Methotrexate; Prognosis; Radiotherapy Dosage; Recurrence | 1985 |
[Treatment of acute lymphoblastic leukemia in children: modified LSA2-L2 therapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Vincristine | 1985 |
Abnormal visual-evoked potentials in leukemic children after cranial radiation.
Topics: Brain; Brain Neoplasms; Child; Child, Preschool; Evoked Potentials, Visual; Humans; Leukemia, Lymphoid; Methotrexate; Prospective Studies; Tomography, X-Ray Computed; Visual Pathways | 1985 |
Risk factors in long-term sequelae of central nervous system prophylaxis in successfully treated children with acute lymphocytic leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Electroencephalography; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Neurologic Examination; Risk; Time Factors; Tomography, X-Ray Computed | 1985 |
[Use of high doses of methotrexate in the program treatment of children with lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Prednisolone; Vincristine | 1985 |
[Use of the O6-Paris-LA-66 program in the treatment of patients with lymphoblastic leukemia under 20 years of age].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Prednisolone; Time Factors; Vincristine | 1985 |
Central nervous system and testicular involvement in acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Testicular Neoplasms | 1985 |
[Acute childhood leukemia: treatment results in children's cancer and leukemia group studies 1972-1981].
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Administration Schedule; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Vincristine | 1985 |
[Organ dysfunctions caused by cancer therapy in children].
Topics: Antineoplastic Agents; Bone Development; Child; Child, Preschool; Cyclophosphamide; Female; Growth Disorders; Heart; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy Dosage; Skull; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1985 |
Methotrexate-vindesine association in leukemia: pharmacokinetic study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Kinetics; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Vindesine | 1985 |
[Encephalopathy in a child with lymphoblastic leukemia treated by an intensive method].
Topics: Child, Preschool; Cobalt Radioisotopes; Combined Modality Therapy; Humans; Leukemia, Lymphoid; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate | 1985 |
[Method of cranial irradiation of children with leukemia].
Topics: Child, Preschool; Combined Modality Therapy; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Meningeal Neoplasms; Methotrexate; Skull | 1985 |
The treatment of childhood acute lymphoblastic leukemia based on the pharmacokinetics of methotrexate in serum and cerebrospinal fluid.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Combined Modality Therapy; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Methotrexate | 1985 |
Improved survival in adult acute lymphoblastic leukemia. Need for more effective CNS prophylaxis.
Topics: Actuarial Analysis; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Diseases; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Prednisone; Time Factors; Vincristine | 1985 |
Varicella in immunodepressed children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chickenpox; Child; Female; Hodgkin Disease; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Prednisone; Procarbazine; Vincristine | 1985 |
Influence of intensive induction and consolidation therapy in acute lymphoblastic leukaemia in children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Doxorubicin; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisolone; Remission Induction; Vincristine | 1985 |
Effective treatment of lymphomas of Burkitt's type and B-ALL in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infusions, Parenteral; Injections, Spinal; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prednisolone; Teniposide | 1985 |
Leukemic meningitis in B-cell chronic lymphocytic leukemia.
Topics: Adult; B-Lymphocytes; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningeal Neoplasms; Meningitis; Methotrexate | 1985 |
[Studies on high-dose methotrexate with citrovorum factor rescue therapy in children: analysis of bone marrow cell kinetics by flow cytometry].
Topics: Bone Marrow; Cell Cycle; Child; Child, Preschool; DNA, Neoplasm; Drug Administration Schedule; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Infant; Infusions, Parenteral; Injections, Intravenous; Leucovorin; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate | 1985 |
Non-Hodgkin's lymphomas in leukaemic phase: incidence, prognosis and therapeutic implications.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bone Marrow Examination; Cyclophosphamide; Doxorubicin; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Middle Aged; Neoplastic Cells, Circulating; Phenotype; Prednisone; Splenomegaly; Vincristine | 1985 |
Remission from central nervous system involvement in adults with acute leukemia. Effect of intensive therapy and prognostic factors.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cytarabine; Humans; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Meningeal Neoplasms; Methotrexate; Prognosis; Radiotherapy Dosage | 1985 |
Marrow transplant experience in children with acute lymphoblastic leukemia: an analysis of factors associated with survival, relapse, and graft-versus-host disease.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Female; Graft vs Host Disease; Humans; Leukemia, Lymphoid; Male; Methotrexate; Recurrence; Whole-Body Irradiation | 1985 |
[Allogeneic bone marrow transplantation after fractionated whole body irradiation. Results at the Kiel transplantation center].
Topics: Acyclovir; Adolescent; Adult; Amphotericin B; Anemia, Aplastic; Bone Marrow Transplantation; Child; Cyclophosphamide; Etoposide; Female; Graft Survival; Graft vs Host Disease; Herpes Genitalis; HLA Antigens; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Nystatin; Prednisolone; Tissue Donors; Whole-Body Irradiation | 1985 |
Bone marrow transplantation for acute leukemia.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporins; Follow-Up Studies; Graft vs Host Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone | 1985 |
Acute lymphoblastic leukaemia in adults in the northern region of England--a study of 75 cases.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Diseases; Combined Modality Therapy; England; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors; Vincristine | 1985 |
Unexpectedly severe toxicity from intensive early treatment of childhood lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Candidiasis; Child; Child, Preschool; Female; Gastrointestinal Diseases; Hospitalization; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Parenteral Nutrition, Total | 1985 |
Consequences of intensive therapy of acute lymphoblastic leukemia in children in initial complete remission lasting more than five years.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Leukemia, Lymphoid; Male; Mental Disorders; Mercaptopurine; Methotrexate; Nervous System Diseases; Prednisone; Time Factors; Vincristine | 1985 |
Quantitative correlations of biological activities of dactinomycin analogs and methotrexate derivatives with van der Waals volume.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Dactinomycin; DNA; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Structure-Activity Relationship; Thymidylate Synthase | 1985 |
[The activity of chromatin of normal and leukemic leukocytes].
Topics: Autoradiography; Binding Sites; Cell Nucleus; Chromosomes; Dactinomycin; DNA; Humans; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Staining and Labeling; Tritium | 1970 |
[Increase in survival in acute lymphoblastic leukemia subjected to a protocol of polychemotherapy].
Topics: Adult; Antineoplastic Agents; Child; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Palliative Care; Prednisone; Prognosis; Vincristine | 1970 |
Intrathecal methotrexate.
Topics: Child; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1971 |
Long remissions in leukaemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Synergism; Female; Follow-Up Studies; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Time Factors; Vincristine | 1971 |
Intrathecal methotrexate.
Topics: Child; Choriocarcinoma; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Pregnancy | 1971 |
Treating the nervous system in acute leukemia.
Topics: Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Nervous System Diseases; Nitrosourea Compounds; Pyrimethamine; Remission, Spontaneous; Time Factors | 1972 |
Treating the nervous system in acute leukaemia.
Topics: Brain Neoplasms; Child; Cytarabine; Humans; Injections, Spinal; Leukemia, Lymphoid; Meninges; Methods; Methotrexate; Neoplasm Metastasis | 1972 |
[Therapy of leukemic and sarcomatous meningopathies in the adult age].
Topics: Adult; Central Nervous System Diseases; Chemical Phenomena; Chemistry; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meninges; Methotrexate; Neoplasms | 1972 |
[The best chemotherapy in the world can only give what it can].
Topics: Antineoplastic Agents; Asparaginase; Drug Combinations; Drug Interactions; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Palliative Care; Prognosis | 1972 |
Radical treatment of acute leukaemia in childhood.
Topics: Acute Disease; Drug Synergism; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Radiotherapy Dosage; Remission, Spontaneous; Time Factors | 1972 |
Methotrexate meningitis.
Topics: Acute Disease; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningitis; Methotrexate | 1972 |
Reservoirs for intraventricular chemotherapy.
Topics: Age Factors; Antineoplastic Agents; Catheterization; Central Nervous System Diseases; Cerebral Ventricles; Child; Child, Preschool; Humans; Injections; Injections, Spinal; Leukemia, Lymphoid; Methods; Methotrexate; Neurologic Manifestations | 1973 |
Letter: Leukaemia of the central nervous system.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Injections, Spinal; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Meninges; Methotrexate | 1974 |
[Antimetabolites in the treatment of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. II].
Topics: Antimetabolites; Azacitidine; Azaguanine; Azauridine; Cell Membrane Permeability; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Immunity, Cellular; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Purines; Pyrimidines | 1974 |
Periodic acid-Schiff reaction, a useful index of duration of complete remission in acute childhood lymphocytic leukemia.
Topics: Bone Marrow Cells; Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Periodic Acid; Peroxidases; Prednisone; Prognosis; Remission, Spontaneous; Staining and Labeling; Vincristine | 1974 |
Value of the combined cytological and cytochemical classification in the management of acute childhood leukemia.
Topics: Bone Marrow Examination; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Hematopoietic Stem Cells; Histocytochemistry; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Periodic Acid; Peroxidases; Prednisone; Prognosis; Remission, Spontaneous; Retrospective Studies; Staining and Labeling; Vincristine | 1974 |
[Acute undifferentiated leukemia--acute lymphocytic leukemia of adults. Differential diagnosis, prognosis, results of therapy].
Topics: Acute Disease; Adult; Age Factors; Aged; Aminosalicylic Acids; Asparaginase; Cytarabine; Cytodiagnosis; Cytoplasm; Daunorubicin; Diagnosis, Differential; Drug Therapy, Combination; Female; Glycogen; Histocytochemistry; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prognosis; Staining and Labeling; Vincristine | 1974 |
[1973 treatment of acute leukemias].
Topics: Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Vinblastine; Vincristine | 1974 |
Marrow grafting in patients with acute leukemia.
Topics: Adolescent; Adult; Antilymphocyte Serum; Bone Marrow Cells; Bone Marrow Transplantation; Child; Cobalt Isotopes; Cyclophosphamide; Cytotoxicity Tests, Immunologic; Female; Graft vs Host Reaction; Histocompatibility Testing; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocyte Culture Test, Mixed; Male; Methotrexate; Middle Aged; Radiation; Thymus Gland; Transplantation, Homologous | 1973 |
Marrow transplantation for aplastic anemia and acute leukemia.
Topics: Anemia, Aplastic; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Child; Cyclophosphamide; Diseases in Twins; Drug Therapy, Combination; Female; Graft vs Host Reaction; Histocompatibility Antigens; Humans; Infections; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Lymphocyte Culture Test, Mixed; Lymphoma; Methods; Methotrexate; Radiotherapy Dosage; Recurrence; Transplantation, Autologous; Transplantation, Homologous | 1974 |
Allogeneic marrow grafting using HL-A matched donor-recipient sibling pairs.
Topics: Animals; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Cyclophosphamide; Dogs; Female; Graft vs Host Reaction; Histocompatibility; Histocompatibility Antigens; Histocompatibility Testing; Hodgkin Disease; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Methotrexate; Radiation Chimera; Sex Factors; Tissue Donors; Transplantation, Homologous | 1971 |
Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors.
Topics: Anemia, Aplastic; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Gastrointestinal Diseases; Graft vs Host Disease; Graft vs Host Reaction; Histocompatibility Antigens; Histocompatibility Testing; HLA Antigens; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Radiation Chimera; Skin Manifestations; Tissue Donors; Transplantation, Homologous | 1974 |
Bone-marrow transplantation in France, 1958-1973.
Topics: Animals; Antilymphocyte Serum; Blood Transfusion; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Drug Therapy, Combination; France; Friend murine leukemia virus; Graft vs Host Disease; Graft vs Host Reaction; Histocompatibility; Humans; Leukemia; Leukemia, Lymphoid; Methotrexate; Mice; Radiation Chimera; Radiation Injuries; Rats; Retroviridae; Transplantation Immunology; Transplantation, Heterologous; Transplantation, Homologous | 1974 |
Allogeneic marrow grafts in man using cyclophosphamide.
Topics: Amidines; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Cytarabine; Cytomegalovirus; Graft vs Host Disease; Graft vs Host Reaction; Herpesviridae; Histocompatibility Testing; Humans; Immunologic Deficiency Syndromes; Injections, Spinal; Karyotyping; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocyte Count; Lymphocyte Culture Test, Mixed; Methotrexate; Phenyl Ethers; Pneumonia; Prednisone; Transplantation Immunology; Transplantation, Homologous | 1974 |
Bone-marrow transplantation following combination chemotherapy immunosuppression (B.A.C.T.) in patients with acute leukemia.
Topics: ABO Blood-Group System; Acute Disease; Blood Group Incompatibility; Bone Marrow Cells; Bone Marrow Transplantation; Child; Chimera; Cyclophosphamide; Cytarabine; Drug Resistance; Drug Therapy, Combination; Female; Graft vs Host Reaction; Histocompatibility; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Nitrosourea Compounds; Thioguanine; Transplantation, Homologous | 1974 |
Acute lymphoblastic leukaemia treated with a combination of prednisone, vincristine, and rubidomycin. Value of pathogen-free rooms.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibiotics, Antineoplastic; Bone Marrow Examination; Child; Child, Preschool; Cyclophosphamide; Drug Synergism; Female; Humans; Infections; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Patient Isolators; Prednisone; Vincristine | 1967 |
Dihydrofolic reductase in human blood cells. II. Enzyme activity after amethopterin and actinomycin C administration.
Topics: Blood Cells; Bone Marrow; Bone Marrow Cells; Dactinomycin; Depression, Chemical; Enzyme Induction; Erythrocytes; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Methotrexate; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase; Time Factors | 1967 |
[Cerebral manifestations in parablastic leukemia in childhood].
Topics: Antimetabolites; Brain Diseases; Carbohydrates; Cell Biology; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Meningitis; Methotrexate; Prednisone; Testicular Neoplasms | 1968 |
Death after intrathecal methotrexate.
Topics: Child; Drug Hypersensitivity; Female; Humans; Leukemia, Lymphoid; Methotrexate | 1969 |
Intrathecal methotrexate.
Topics: Adolescent; Child; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate | 1970 |
EEG studies in children with leukaemia.
Topics: Adolescent; Antibiotics, Antineoplastic; Brain Diseases; Child; Child, Preschool; Cyclophosphamide; Electroencephalography; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1970 |
Globin chain synthesis in sickle cell trait under conditions of folate antagonism.
Topics: Adolescent; Allopurinol; Anemia, Sickle Cell; Bone Marrow Examination; Carbon Radioisotopes; Electrophoresis, Disc; Electrophoresis, Starch Gel; Erythrocytes; Female; FIGLU Test; Folic Acid Deficiency; Hemoglobins; Hemoglobins, Abnormal; Humans; Leucine; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine | 1974 |
Methotrexate analogs. 4.7-Methyl derivatives of methotrexate and dichloromethotrexate. A new synthesis and some biological studies.
Topics: Animals; Cell Line; Chlorine; Enterococcus faecalis; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Methane; Methotrexate; Mice; Spectrophotometry, Ultraviolet | 1974 |
Cytogenetic studies in 45 patients with acute lymphocytic leukemia.
Topics: Adolescent; Adult; Aneuploidy; Blood Cells; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Down Syndrome; Female; Humans; Infant; Karyotyping; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1969 |
[Urinary elimination of beta aminoisobutyric acid in malignant hemopathies].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aminoisobutyric Acids; Asparagine; Child; Female; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Thymine; Vinblastine | 1971 |
Cellular immune reactions to human leukemia.
Topics: Antigens, Neoplasm; Bone Marrow; Bone Marrow Cells; Cell Membrane; Chromium Isotopes; Cytotoxicity Tests, Immunologic; Humans; Immunity, Cellular; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocyte Culture Test, Mixed; Mercaptopurine; Methotrexate; Prednisone; Skin Tests; Thymidine; Tritium; Vincristine | 1972 |
Immunotherapy in previously treated acute lymphatic leukemia.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Antigen-Antibody Reactions; Antigens, Viral; Asparaginase; BCG Vaccine; Cell Membrane; Child; Child, Preschool; Dactinomycin; Humans; Immunoglobulins; Immunologic Memory; Immunotherapy; Infant; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Methotrexate; Middle Aged; Mumps; Mycobacterium bovis; Remission, Spontaneous; Skin Tests; Smallpox; Time Factors; Tuberculin Test | 1973 |
The effect of autologous serum on lymphocyte response to human leukemia cells.
Topics: Adolescent; Adult; Asparaginase; Child; Child, Preschool; Cytarabine; Female; Humans; Immune Sera; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocytes; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitrosourea Compounds; Prednisolone; Prognosis; Thioguanine; Vincristine | 1974 |
Folic acid metabolism in Rauscher murine leukemia and effect of methotrexate on the blood picture.
Topics: Animals; Folic Acid; Injections, Intravenous; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Methotrexate; Mice; Mice, Inbred BALB C; Plasma; Rauscher Virus; Spleen | 1974 |
The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man.
Topics: Adult; Blood; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Child; Child, Preschool; Choriocarcinoma; Chromatography; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Liver Neoplasms; Male; Melanoma; Methotrexate; Middle Aged; Pregnancy; Testicular Neoplasms; Tritium; Urine | 1965 |
[Treatment of acute lymphoblastic leukemia during a remission by irradiation of the central nervous system and subsequent administration of 8 chemotherapeutic agents].
Topics: Adolescent; Adult; Alkaloids; Antineoplastic Agents; Azathioprine; Azirines; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Injections, Intravenous; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1966 |
Acute leukemias and Burkitt's lymphoma. Present status of therapy.
Topics: Antineoplastic Agents; Asparaginase; Burkitt Lymphoma; Choriocarcinoma; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Female; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Melphalan; Mercaptopurine; Methotrexate; Prednisone; Pregnancy; Vincristine; Wilms Tumor | 1968 |
[The course of acute leukemia. 456 cases].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Prognosis | 1969 |
[L-Asparaginase in the treatment of acute leukemia].
Topics: Acute Disease; Adolescent; Adult; Aged; Asparaginase; Child, Preschool; Drug Hypersensitivity; Drug Tolerance; Hematopoiesis; Humans; Immunosuppressive Agents; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Liver Function Tests; Methotrexate; Middle Aged; Prednisone; Vincristine | 1970 |
[Leukemic meningitis. Statistics of 33 cases].
Topics: Electroencephalography; Hematologic Diseases; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Meningitis; Methotrexate | 1970 |
Correctable complications of neoplastic disease. II. Meningeal leukemia.
Topics: Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms, Nerve Tissue | 1971 |
E Pluribus Unum: Presidential address.
Topics: Acute Disease; Africa, Southern; Asparaginase; Daunorubicin; Europe; Female; Government; History, 18th Century; Hydatidiform Mole; Immunization, Passive; International Cooperation; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Pregnancy; Remission, Spontaneous; Trophoblastic Neoplasms; United States; Vincristine | 1971 |
Fatalities during remission of childhood leukemia.
Topics: Adolescent; Autopsy; Child; Child, Preschool; Cytomegalovirus; Daunorubicin; Female; Herpesviridae Infections; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Mycoses; Pneumonia, Pneumocystis; Prednisone; Remission, Spontaneous; Salivary Gland Diseases; Vincristine | 1972 |
Infectious mononucleosis prior to acute leukemia: a possible role for the Epstein-Barr virus.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Animals; Antibodies, Viral; Asparaginase; Cyclophosphamide; Cytarabine; Fluorescent Antibody Technique; Guinea Pigs; Herpesvirus 4, Human; Humans; Hydrocortisone; Infectious Mononucleosis; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Sheep; Vincristine | 1972 |
Methotrexate pneumonitis: case report and review of the literature.
Topics: Carcinoma, Small Cell; Eosinophilia; Humans; Leukemia, Lymphoid; Lung Neoplasms; Male; Methotrexate; Middle Aged; Pneumonia; Prednisone; Radiography | 1972 |
Cytocentrifugation in the management of central nervous system leukemia.
Topics: Arachnoiditis; Central Nervous System Diseases; Centrifugation; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms, Nerve Tissue | 1972 |
Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.
Topics: Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Culture Techniques; Cyclic AMP; Dactinomycin; Deoxyuridine; DNA; Folic Acid; Humans; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Methotrexate; Mitosis; Phosphodiesterase Inhibitors; Puromycin; RNA; Theophylline; Thymidine; Tritium | 1973 |
Studies of immunological reactivity following syngeneic or allogeneic marrow grafts in man.
Topics: Anemia, Aplastic; Antibodies; Bacteriophages; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Cytomegalovirus; Erythrocytes; Hemagglutination Tests; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphoma; Methotrexate; Nitrobenzenes; Radiation Effects; Skin Tests; Transplantation Immunology; Transplantation, Homologous; Viral Plaque Assay | 1973 |
[Report on experiences in the treatment of childhood leukoses using irradiation of the CNS and combined cytostatic medication].
Topics: Central Nervous System; Child; Follow-Up Studies; Humans; Leukemia, Lymphoid; Methods; Methotrexate; Radiation Effects; Radiotherapy Dosage; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
[Irradiation of the CNS in acute leukoses within the scope of 1st attack treatment].
Topics: Central Nervous System; Child; Cobalt Radioisotopes; Cyclophosphamide; Humans; Leukemia, Lymphoid; Methotrexate; Radiation Effects; Radioisotope Teletherapy; Radiotherapy Dosage; Time Factors | 1973 |
Transient monoclonal gammopathy associated with cytomegalovirus infection.
Topics: Adolescent; Antibodies, Viral; Blood Protein Disorders; C-Reactive Protein; Cytomegalovirus; Cytomegalovirus Infections; Female; Hemagglutination Tests; Humans; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin A; Immunoglobulin Fragments; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Leukemia; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous; Saliva; Urine | 1974 |
Detection of chemical mutagens using a host-mediated assay (L5178Y) mutagenesis system.
Topics: Animals; Biological Assay; Bromodeoxyuridine; Cell Line; Cells, Cultured; Clone Cells; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Leukemia, Lymphoid; Mesylates; Methotrexate; Mice; Mutagens; Mutation; Thymidine | 1974 |
Acute lymphoblastic leukemia of childhood: results of combination therapy.
Topics: Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cystitis; Drug Therapy, Combination; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Infant; Infections; Leukemia; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pneumonia, Viral; Prednisone; Remission, Spontaneous; Skin Diseases; Vincristine; Viral Vaccines; Virus Diseases | 1974 |
Childhood acute lymphoblastic leukemia. a survey of children treated between 1963 and 1972 at Children's Memorial Hospital, Chicago.
Topics: Adolescent; Bacterial Infections; Central Nervous System Diseases; Chicago; Child; Child, Preschool; Cyclophosphamide; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1974 |
Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs.
Topics: Adolescent; Adult; Antibody-Producing Cells; Antigens; Blood Donors; Blood Platelets; Blood Protein Electrophoresis; Bone Marrow Transplantation; Child; Cobalt Isotopes; Cytogenetics; Cytotoxicity Tests, Immunologic; Enzymes; Erythrocytes; Female; Graft Rejection; Graft vs Host Reaction; Histocompatibility Testing; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Male; Methotrexate; Middle Aged; Transplantation Immunology; Transplantation, Homologous | 1971 |
Bone marrow transplantation from HL-A matched donors to patients with acute leukemia. Toxicity and antileukemic effect.
Topics: Adolescent; Adult; Asparaginase; Blood Transfusion; Bone Marrow Transplantation; Child; Cyclophosphamide; Cytarabine; Cytomegalovirus Infections; Daunorubicin; Female; Graft vs Host Reaction; Histocompatibility Testing; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1972 |
Leukemic transformation of engrafted human marrow.
Topics: Bone Marrow Cells; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Cobalt Isotopes; Female; Graft vs Host Reaction; Histocompatibility; Histocompatibility Testing; Humans; Leukemia, Lymphoid; Lymphocyte Culture Test, Mixed; Male; Methotrexate; Radiation Chimera; Radioisotope Teletherapy | 1972 |
Management of acute renal failure due to marked hyperuricemia.
Topics: Acute Kidney Injury; Adolescent; Allopurinol; Bicarbonates; Humans; Infusions, Parenteral; Kidney; Leukemia, Lymphoid; Male; Methotrexate; Potassium; Prednisone; Radiography; Regional Blood Flow; Renal Dialysis; Sodium; Thrombocytopenia; Uric Acid; Vincristine | 1972 |
[Lymphoblastic meningitis. Incidence, prevention and treatment].
Topics: Cytarabine; Humans; Leukemia, Lymphoid; Meningitis; Methotrexate | 1972 |
Impaired lymphocyte transformation in leukemic patients after intensive therapy.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cobalt Isotopes; Cytarabine; Female; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Mitogens; Prednisone; Radiation Effects; Remission, Spontaneous; Thymidine; Time Factors; Tritium; Vincristine | 1972 |
Chemotherapy and immunotherapy of three human lymphomas serially transplantable in the neonatal Syrian hamster.
Topics: Age Factors; Animals; Animals, Newborn; Antilymphocyte Serum; Cricetinae; Cyclophosphamide; Dactinomycin; Female; Immune Sera; Immunization, Passive; Leukemia, Lymphoid; Lymphocyte Transfusion; Lymphoma; Maternal-Fetal Exchange; Mercaptopurine; Methotrexate; Neoplasm Transplantation; Neoplasms, Experimental; Prednisone; Pregnancy; Spleen; Time Factors; Vincristine | 1972 |
[Clinical trial of daunomycin in acute leukemia in adults].
Topics: Adolescent; Adult; Aged; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1972 |
[Treatment of acute lymphoblastic leukosis: evaluation of the maintenance and reinduction standards. Analysis of 33 cases].
Topics: Acute Disease; Adult; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Recurrence; Remission, Spontaneous; Vincristine | 1972 |
Cell kinetics and chemotherapy in acute leukemia.
Topics: Asparaginase; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cells, Cultured; Cyclophosphamide; Cytarabine; DNA; Drug Combinations; Exchange Transfusion, Whole Blood; Humans; Hydrocortisone; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Methylprednisolone; Mitosis; Prednisone; Thymidine; Tritium; Vincristine | 1972 |
[Therapy with vincristine].
Topics: Asparaginase; Child; Child, Preschool; Drug Synergism; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1972 |
[Experience in the therapy of acute leukemia in the period from March, 1959 to February, 1971].
Topics: Adolescent; Adult; Asparaginase; Child; Child, Preschool; Cytarabine; Evaluation Studies as Topic; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Remission, Spontaneous; Vincristine | 1972 |
[Role of daunomycin in the treatment of acute leukemia in children].
Topics: Bone Marrow Diseases; Child; Daunorubicin; Dexamethasone; Drug Synergism; Evaluation Studies as Topic; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone; Vincristine | 1972 |
Central nervous system involvement in leukaemia.
Topics: Brain; Brain Diseases; Brain Neoplasms; Ependyma; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate | 1972 |
Recovery of meningeal leukaemia. A case report.
Topics: Adult; Central Nervous System Diseases; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Prednisone | 1972 |
Encephalopathy in acute leukaemia associated with methotrexate therapy.
Topics: Acute Disease; Adult; Ataxia; Brain Diseases; Child; Child, Preschool; Cognition Disorders; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Psychoses, Substance-Induced; Tremor | 1972 |
Central nervous system involvement in acute childhood leukemia.
Topics: Adolescent; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Child, Preschool; Cytodiagnosis; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Methotrexate; Spinal Puncture | 1972 |
[Results of acute lymphoblastic leukemia treatment in children. (Apropos of 58 cases)].
Topics: Adolescent; Child; Child, Preschool; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Vincristine | 1972 |
Nine years' experience with "total therapy" of childhood acute lymphocytic leukemia.
Topics: Central Nervous System; Child; Cobalt Isotopes; Cyclophosphamide; Humans; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Radioisotope Teletherapy; Remission, Spontaneous; Vincristine | 1972 |
Priapism in acute lymphoblastic leukemia.
Topics: Central Nervous System; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Lumbosacral Plexus; Male; Methotrexate; Neoplastic Cells, Circulating; Penis; Priapism; Spinal Puncture | 1972 |
Phytohaemagglutinin stimulation of peripheral lymphocytes in children with acute lymphoblastic leukaemia during remission.
Topics: Adolescent; Cell Transformation, Neoplastic; Child; Child, Preschool; Cyclophosphamide; Humans; In Vitro Techniques; Lectins; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Stimulation, Chemical; Thymidine; Time Factors; Tritium; Vincristine | 1972 |
[Treatment of acute lymphatic leukemia in children].
Topics: Adolescent; Child; Child, Preschool; Daunorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Time Factors; Vincristine | 1972 |
DNA synthesis in normal and leucemic cells as related to therapy with cytotoxic drugs.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; DNA; DNA Nucleotidyltransferases; DNA, Neoplasm; Doxorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Prednisolone; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymine Nucleotides | 1972 |
Intermittent therapy with 6-mercaptopurine (NSC-755) and methotrexate (NSC-740) given intravenously to adults with acute leukemia.
Topics: Adrenal Cortex Hormones; Bone Marrow; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Mercaptopurine; Methotrexate; Prognosis; Remission, Spontaneous; Time Factors | 1972 |
Total therapy of acute lymphocytic leukemia.
Topics: Follow-Up Studies; Humans; Leukemia, Lymphoid; Methotrexate; Pilot Projects; Prednisone; Remission, Spontaneous; Vincristine | 1972 |
Treatment of acute lymphoblastic leukaemia.
Topics: Asparaginase; Central Nervous System Diseases; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1972 |
Pneumonitis in acute lymphatic leukemia during methotrexate therapy.
Topics: Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Mycoplasma; Pneumonia; Radiography; Respiratory Syncytial Viruses | 1973 |
[Chemotherapy and attempts at immunotherapy in treatment of acute lymphoid leukemia].
Topics: Acute Disease; Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Humans; Immunotherapy; Leukemia, Lymphoid; Mercaptopurine; Methods; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Vincristine | 1972 |
Cell kinetics in human acute lymphoblastic leukemia: computer simulation with discrete modeling techniques.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Computers; Cytarabine; DNA; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Mitosis; Models, Theoretical; Thymidine; Tritium; Vincristine | 1973 |
Retrospective study and perspectives in the treatment of meningeal leukaemia.
Topics: Adolescent; Adult; Brain Diseases; Central Nervous System Diseases; Cerebrospinal Fluid; Cobalt Isotopes; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1972 |
"Total therapy" studies of acute lymphocytic leukemia in children. Current results and prospects for cure.
Topics: Antineoplastic Agents; Central Nervous System; Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Radiation Effects; Radiotherapy Dosage; Remission, Spontaneous; Time Factors; Vincristine | 1972 |
[Successful intrathecal treatment of meningeal leukaemia with methotrexate in the adult].
Topics: Adult; Blood-Brain Barrier; Cortisone; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate; Prednisone; Time Factors | 1973 |
Urticaria pigmentosa and acute lymphoblastic leukemia.
Topics: Acute Disease; Asparaginase; Bone Marrow Examination; Bone Neoplasms; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Radiography; Remission, Spontaneous; Urticaria Pigmentosa; Vincristine | 1973 |
[Therapy of acute leukemia. Opinion of Prof. Franco Mandelli].
Topics: Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Synergism; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Thioguanine; Vincristine | 1973 |
Induction and maintenance of remission in acute leukemia. Effectiveness of combination therapy in 227 patients.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
[Intrathecal therapy of meningosis leucemica using methotrexate].
Topics: Adult; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meningioma; Methotrexate | 1973 |
Attempts at immunotherapy of 100 patients with acute lymphoid leukemia: some factors influencing results.
Topics: Animals; Bone Marrow Examination; Central Nervous System; Corynebacterium; Cytarabine; Cytotoxicity Tests, Immunologic; Disease Models, Animal; Female; Humans; Immune Sera; Immunotherapy; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Activation; Male; Methotrexate; Mice; Mice, Inbred AKR; Remission, Spontaneous | 1972 |
Irradiation of C.N.S. in leukaemia.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy Dosage; Remission, Spontaneous; Spine | 1973 |
Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.
Topics: Adolescent; Adult; Aged; Antigens; Azathioprine; Child; Child, Preschool; Chromium Isotopes; Cyclophosphamide; Cytotoxicity Tests, Immunologic; Diseases in Twins; Female; Humans; Immunity, Cellular; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Male; Methotrexate; Middle Aged; Prednisone | 1972 |
Acute leukemia presenting as a breast mass.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Biopsy, Needle; Breast Neoplasms; Child; Cytarabine; Daunorubicin; Diagnosis, Differential; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Menarche; Mercaptopurine; Methotrexate; Prednisolone; Sulfates; Vincristine | 1973 |
Reversible drug-induced sterility in a patient with acute leukemia.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Follow-Up Studies; Humans; Infertility, Male; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Paternity; Prednisone; Remission, Spontaneous; Spermatozoa; Time Factors | 1973 |
Infection during induction of remission in acute lymphocytic leukemia.
Topics: Adolescent; Bacterial Infections; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Infant; Infections; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Mycoses; Neutrophils; Prednisone; Remission, Spontaneous; Vincristine; Virus Diseases | 1973 |
Optimism in leukemia treatment.
Topics: Acute Disease; Adult; Child; Cyclophosphamide; Cytarabine; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisolone; Thioguanine; Vincristine | 1973 |
Acute leukemia with C-G chromosome translocation.
Topics: Adult; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 6-12 and X; Humans; Injections, Spinal; Karyotyping; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pedigree; Prednisone; Quinacrine; Skin; Vincristine | 1973 |
Vertebral compression in childhood leukemia.
Topics: Age Factors; Child; Female; Fractures, Spontaneous; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Osteoporosis; Prednisone; Radiography; Remission, Spontaneous; Spinal Diseases; Thoracic Vertebrae | 1973 |
[Serious neurological syndrome observed after first intraspinal administration of methotrexate in a child with acute lymphatic leukemia].
Topics: Apnea; Brain; Child, Preschool; Drug Hypersensitivity; Electroencephalography; Humans; Injections; Leukemia, Lymphoid; Male; Methotrexate; Neurologic Manifestations; Seizures; Spine | 1973 |
Hypersplenism in a child with acute lymphatic leukemia.
Topics: Child; Female; Humans; Hypersplenism; Leukemia, Lymphoid; Leukocytes; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Splenectomy | 1973 |
Bone-marrow lymphocytes in acute lymphoid leukaemia: effect of therapeutic regimes.
Topics: Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Retrospective Studies; Statistics as Topic; Vincristine | 1973 |
Cyclic chemotherapy in acute lymphoblastic leukaemia of childhood: 5-year survivals.
Topics: Acute Disease; Bone Marrow Cells; Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1973 |
Bone-marrow toxicity of methotrexate: a reassessment.
Topics: Administration, Oral; Blood Platelets; Bone Marrow Cells; Bone Marrow Diseases; Child; Hemoglobinometry; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Models, Biological; Regeneration; Time Factors | 1973 |
Copper and zinc concentration in the plasma of leukaemic children.
Topics: Child; Child, Preschool; Copper; Hepatomegaly; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Remission, Spontaneous; Spectrophotometry, Atomic; Splenomegaly; Zinc | 1973 |
Pomp combination chemotherapy of adult acute leukemia.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Bone Marrow; Digestive System; Evaluation Studies as Topic; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver; Mercaptopurine; Methotrexate; Middle Aged; Paresthesia; Prednisone; Prognosis; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
[3-year results of cytostatic combination therapy in immature leukoses of adults in comparison with earlier therapeutic methods].
Topics: Acute Disease; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1973 |
Management of acute leukemia in children.
Topics: Acute Disease; Child; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1973 |
[A better than 4-year survival in acute lymphoblastic leukemia in children].
Topics: Acute Disease; Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
[Active immunotherapy in acute lymphoid leukemia in children. Influence of several factors on the results].
Topics: Adolescent; Antigens, Neoplasm; BCG Vaccine; Bone Marrow Examination; Cell- and Tissue-Based Therapy; Child; Child, Preschool; Daunorubicin; Female; Humans; Immunotherapy; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Retrospective Studies; Vincristine | 1973 |
An immunological approach to the treatment of malignant disease.
Topics: Child; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Neoplasms | 1973 |
Neurotoxicity and elevated cerebrospinal-fluid methotrexate concentration in meningeal leukemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Half-Life; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Nervous System Diseases; Spinal Cord Diseases | 1973 |
Effects of chemotherapeutic agents on cell cycle and cellular proliferation: basic and clinical considerations.
Topics: Autoradiography; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; DNA; Drug Antagonism; Drug Combinations; Hodgkin Disease; Humans; Hydrocortisone; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mitosis; Thymidine; Tritium; Vincristine | 1973 |
Our experience with cytosine arabinoside in the treatment of acute haemoblastoses.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cytarabine; Evaluation Studies as Topic; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
Encephalopathy following CNS prophylaxis in childhood lymphoblastic leukemia.
Topics: Brain Diseases; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Radiotherapy | 1973 |
Editorial: Treatment of childhood leukemia.
Topics: Acute Disease; Age Factors; Central Nervous System; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Radiation Effects; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
Letter: Pyoderma gangrenosum and leukemia.
Topics: Acute Disease; Adolescent; Female; Gangrene; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Pyoderma; Rifampin | 1973 |
Serial in vitro bone marrow culture in acute lymphocytic leukemia.
Topics: Adolescent; Adult; Allopurinol; Bone Marrow Cells; Cell Count; Child; Child, Preschool; Culture Techniques; Cytarabine; Drug Therapy, Combination; Embryo, Mammalian; Female; Humans; Injections, Spinal; Kidney; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Vincristine | 1973 |
[A new approach to chemotherapeutic combinations in the treatment of solid tumors: trail synchronization, recruitement].
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Methotrexate; Mitosis; Neoplasms; Vincristine | 1973 |
Somnolence after prophylactic cranial irradiation in children with acute lymphoblastic leukaemia.
Topics: Age Factors; Brain; Cerebrospinal Fluid; Child; Child, Preschool; Electroencephalography; Feeding and Eating Disorders; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Radiation Effects; Radiotherapy; Sleep | 1973 |
Factors that influence the appearance of central nervous system leukemia.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid; Cobalt Radioisotopes; Daunorubicin; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Radioisotope Teletherapy; Recurrence; Retrospective Studies; Vincristine | 1973 |
Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 66-Paris).
Topics: Adolescent; Adult; Age Factors; Aged; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Heart; Heart Diseases; Humans; Infant; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission, Spontaneous; Sex Factors; Time Factors; Vincristine | 1973 |
[Therapy of acute leukemias].
Topics: Adrenal Cortex Hormones; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Thioguanine; Vincristine | 1973 |
[Significance of cell kinetics in the planning of treatment of acute leukemias].
Topics: Cell Division; Child; Humans; Injections, Intravenous; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mitosis; Regeneration | 1973 |
[Leukemic meningosis in adults. Clinical picture--liquor cytology--therapy].
Topics: Adult; Aged; Cerebrospinal Fluid; Female; Headache; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Meningitis; Methotrexate; Middle Aged; Prognosis | 1973 |
Acute leukemia in adults.
Topics: Adult; Agranulocytosis; Antineoplastic Agents; Cytarabine; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone; Thrombocytopenia; Time Factors | 1973 |
New hopes in acute lymphoblastic leukemia.
Topics: Brain Neoplasms; Child; Humans; Leukemia, Lymphoid; Meninges; Methotrexate; Remission, Spontaneous | 1973 |
Proceedings: Daunorubicin cardiac toxicity in children with acute lymphocytic leukemia.
Topics: Adolescent; Age Factors; Autopsy; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Edema; Electrocardiography; Female; Heart; Heart Conduction System; Heart Failure; Humans; Leukemia, Lymphoid; Male; Methotrexate; Myocardium; Myofibrils; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
Rationale and results of combination chemotherapy and central nervous system irradiation in acute lymphocytic leukemia.
Topics: Adolescent; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cobalt Radioisotopes; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Radiation Effects | 1973 |
Combination therapy involving L-asparaginase in acute leukemia.
Topics: Administration, Oral; Adolescent; Adult; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1973 |
Eventual control of clinical leukemia.
Topics: Administration, Oral; Africa; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone; United States; Vincristine | 1973 |
[Combined cytostatic therapy of acute leukemia in children].
Topics: Antineoplastic Agents; Child; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1973 |
[Treatment of acute lymphatic leukemia].
Topics: Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1973 |
Methotrexate-induced bone pain in childhood leukemia.
Topics: Bone Diseases; Bone Regeneration; Child; Child, Preschool; Female; Fractures, Bone; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteoporosis; Pain; Radiography; Remission, Spontaneous; Time Factors | 1973 |
[Therapeutical induced cytochemical changes in acute leukemia].
Topics: Adolescent; Adult; Aminosalicylic Acids; Asparaginase; Blood Cells; Bone Marrow; Bone Marrow Cells; Daunorubicin; Diagnosis, Differential; Doxorubicin; Esterases; Histocytochemistry; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Peroxidases; Prednisolone; Thioguanine; Vincristine | 1974 |
[Kinetic effect of cytostatic drugs on the generation cycle of human leukaemic blast cells in vivo. A review].
Topics: Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; DNA Nucleotidyltransferases; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Mitosis; Prednisone; Thymidine; Time Factors; Vincristine | 1974 |
Letter: "Aseptic meningoencephalopathy" or "neurotoxicity" in leukemia?
Topics: Central Nervous System Diseases; Child; Humans; Leukemia, Lymphoid; Methotrexate | 1974 |
Occult adenocarcinoma of the pancreas in a 17-year-old patient with immunosuppressed leukemia.
Topics: Adenocarcinoma; Adolescent; Age Factors; Autopsy; Brain Neoplasms; Cyclophosphamide; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasms, Multiple Primary; Pancreas; Pancreatic Neoplasms; Prednisone; Vincristine | 1974 |
Fourteen relapses of acute lymphoblastic leukaemia in a child.
Topics: Agranulocytosis; Asparaginase; Blood Cell Count; Bone Marrow Examination; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Hemoglobins; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pneumonia; Prednisone; Recurrence; Vincristine | 1973 |
[Acute lymphatic leukemia in adults. Therapy and prognosis in comparison with acute myelogenous leukemia].
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Asparaginase; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Methylprednisolone; Middle Aged; Paresis; Prognosis; Radiotherapy Dosage; Remission, Spontaneous; Vincristine | 1974 |
[Electroencephalographic and neurologic changes in children with acute lymphoblastic leukemia subjected to intraspinal prevention with amethopterin and methylprednisolone].
Topics: Brain Diseases; Drug Synergism; Electroencephalography; Humans; Leukemia, Lymphoid; Methotrexate; Methylprednisolone; Neurologic Manifestations | 1974 |
Ten cases of so-called long survival in children with acute lymphoblastic leukemia.
Topics: Bone Marrow Cells; Child; Child, Preschool; Diet; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Remission, Spontaneous; Time Factors; Vincristine | 1974 |
[Results obtained in children with acute lymphoblastic leukemia in a period of 10 years with the combination of polychemotherapy and radiotherapy of the central nervous system].
Topics: Acute Disease; Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy Dosage; Spinal Cord; Spinal Cord Neoplasms | 1973 |
[Leukemic infiltrates into the central nervous system. Early symptoms, clinical aspects and indications for prophylactic treatment].
Topics: Acute Disease; Adolescent; Age Factors; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Intracranial Pressure; Leukemia, Lymphoid; Male; Meninges; Methotrexate | 1974 |
Intensive chemotherapy in children with acute lymphoblastic leukemia (L-2 protocol).
Topics: Administration, Oral; Adolescent; Age Factors; Antineoplastic Agents; Asparaginase; Carmustine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Hydroxyurea; Infant; Infections; Injections, Intravenous; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1974 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, Animal; Drug Therapy, Combination; Ethylenediamines; Fluorenes; Fluorouracil; Interferon Inducers; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Prednisolone; Thioxanthenes; Vincristine | 1974 |
Cytology of the cerebrospinal fluid in children with acute lymphoblastic leukemia.
Topics: Acute Disease; Cell Count; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Cytarabine; Female; Humans; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous | 1974 |
Effect of methotrexate on deoxyribonucleotide pools and DNA synthesis in human lymphocytic cells.
Topics: Adenosine; Adenosine Triphosphate; Cell Line; Cells, Cultured; Chromatography; Cytosine Nucleotides; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Guanosine Triphosphate; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; RNA, Neoplasm; Thymine Nucleotides; Tritium | 1974 |
Leukemic iris infiltration in a case of meningeal leukemia.
Topics: Adult; Eye Manifestations; Humans; Iris; Leukemia; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
[Hypocalcemia and hyperuricemia during treatment of acute lymphoblastic leukemia in childhood].
Topics: Acute Disease; Allopurinol; Child, Preschool; Humans; Hyperkalemia; Hypocalcemia; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Uric Acid | 1974 |
[Indications for radiotherapy of acute leukemia in children with special reference to clinically non-manifest involvement of CNS].
Topics: Age Factors; Brain Neoplasms; Child; Cobalt Radioisotopes; Cyclophosphamide; Germany, West; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasm Metastasis; Prednisolone; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Remission, Spontaneous; Spinal Cord Neoplasms; Vincristine | 1974 |
[Prognostic change of leukemias in childhood (author's transl)].
Topics: Asparaginase; Child; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Remission, Spontaneous; Vincristine | 1974 |
[Smouldering acute leukemia in a child].
Topics: Acute Disease; Child; Child, Preschool; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Time Factors; Vincristine | 1974 |
Additive therapy in the maintenance of remission in acute lymphoblastic leukemia of childhood: the effect of the initial leukocyte count.
Topics: Adolescent; Age Factors; Blood; Brain Neoplasms; Child; Child, Preschool; Dactinomycin; Digestive System; Drug Therapy, Combination; Fluorouracil; Humans; Leukemia, Lymphoid; Leukocyte Count; Mechlorethamine; Methotrexate; Prednisone; Prognosis; Time Factors | 1974 |
Evaluation of induction of remission, intensification, and central nervous system prophylactic treatment in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infections; Injections, Spinal; Leukemia, Lymphoid; Leukopenia; Male; Methotrexate; Middle Aged; Radiotherapy Dosage; Remission, Spontaneous | 1974 |
Intracellular lysozyme in mature neutrophils and blast cells in acute leukemia.
Topics: Adult; Cell Separation; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Muramidase; Neutrophils; Recurrence | 1974 |
Management of acute leukaemia in childhood.
Topics: Brain Neoplasms; Child; Child, Preschool; Cross Infection; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Infant; Injections, Intravenous; Leukemia; Leukemia, Lymphoid; Male; Measles; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Spinal Neoplasms; Vincristine | 1974 |
Morphological criteria for prognostication of acute lymphoblastic leukaemia.
Topics: Bone Marrow Cells; Central Nervous System Diseases; Child; Child, Preschool; Female; Hepatomegaly; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Male; Methotrexate; Prognosis; Remission, Spontaneous; Splenomegaly | 1974 |
The prognosis of acute leukaemia in childhood.
Topics: Acute Disease; Antineoplastic Agents; Bone Marrow Examination; Brain Neoplasms; Child; Drug Therapy, Combination; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisone; Prognosis; Recurrence; Remission, Spontaneous; Vincristine | 1974 |
[Treatment of acute lymphoblastic leukemia. Evaluation of 6-year-cooperative studies in Argentina (author's transl)].
Topics: Adult; Central Nervous System Diseases; Child; Daunorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
The inhibitory effect of leukaemia associated antigen and leukaemic serum on the leukocyte migration of children with acute leukaemia in remission.
Topics: Antigens, Neoplasm; Cell Migration Inhibition; Child; Humans; Immune Sera; Leukemia, Lymphoid; Leukocytes; Mercaptopurine; Methods; Methotrexate; Remission, Spontaneous | 1974 |
7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.
Topics: Animals; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mice; Oxidation-Reduction; Polycythemia Vera; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Cerebral calcification in childhood leukemia mimicking Sturge-Weber syndrome. Report of two cases.
Topics: Angiomatosis; Biopsy; Brain; Calcinosis; Central Nervous System Diseases; Cerebral Angiography; Child; Child, Preschool; Cobalt Radioisotopes; Diagnosis, Differential; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Radioisotope Teletherapy; Remission, Spontaneous; Sturge-Weber Syndrome; Tomography, X-Ray; Vincristine | 1974 |
Blood and neoplastic diseases. Rational approach to the chemotherapy of human malignant disease-II.
Topics: Antineoplastic Agents; Brain Neoplasms; Busulfan; Cell Count; Cell Division; Cytarabine; Diffusion; Drug Tolerance; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Lymphoma; Methotrexate; Multiple Myeloma; Neoplasms; Vincristine | 1974 |
Letter: Adult acute leukemia: cerebral degeneration.
Topics: Adult; Brain Diseases; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy | 1974 |
An unusual response of leukemic cutis treated with chemotherapy.
Topics: Acute Disease; Adult; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Skin Neoplasms | 1974 |
[Neuroleukemia].
Topics: Adolescent; Adult; Child; Child, Preschool; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate; Nervous System Diseases; Radioisotope Teletherapy; Remission, Spontaneous | 1974 |
Blood and neoplastic diseases. Acute lymphoblastic leukaemia.
Topics: Arachnoid; Asparaginase; Brain Neoplasms; Cerebrospinal Fluid; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunotherapy; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisolone; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
Comparison of the effects of methotrexate and pyrimethamine on L5178Y lymphoblasts in cell culture.
Topics: Adenosine; Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Centrifugation; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Mice; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1973 |
Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil.
Topics: Animals; Cell Line; Cells, Cultured; Drug Antagonism; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice; Purines; Spectrophotometry; Tritium; Uracil Nucleotides | 1973 |
Neurological involvement in the lymphomas and leukaemias. Prophylaxis, diagnosis and chemotherapy.
Topics: Cytarabine; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Neurologic Manifestations; Radiography | 1974 |
Comparative results obtained in the treatment of acute leukemia.
Topics: Antineoplastic Agents; Asparaginase; Carmustine; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Meningitis; Methotrexate; Prednisone; Thioguanine; Vincristine | 1973 |
Clinical and immunological recovery of children with acute lymphocytic leukemia admitted to "total therapy" studies.
Topics: Antibody Formation; Drug Therapy, Combination; Evaluation Studies as Topic; Humans; Immunoglobulin G; Immunoglobulin M; Leukemia, Lymphoid; Lymphocytes; Meningitis; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Radiotherapy Dosage; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
[Central nervous system complications in acute leukemia].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate | 1974 |
Bactericidal capacity of peripheral blood leucocytes in relation to bacterial infections in acute lymphoblastic leukaemia in childhood.
Topics: Adolescent; Blood Bactericidal Activity; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Leukocytes; Male; Mercaptopurine; Methotrexate; Phagocytosis; Prognosis; Remission, Spontaneous; Staphylococcal Infections; Vincristine | 1974 |
Submicroscopic changes in leukaemia cells of the cerebrospinal fluid following intrathecal methotrexate.
Topics: Brain Neoplasms; Cell Nucleus; Cerebrospinal Fluid; Child; Cytoplasm; Golgi Apparatus; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Lymphocytes; Meninges; Methotrexate; Microscopy, Electron | 1974 |
Prophylactic central nervous system therapy with cranial irradiation and intrathecal methotrexate in acute lymphoblastic leukemia of childhood.
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Cobalt Radioisotopes; Drug Therapy, Combination; Electroencephalography; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Meningism; Methotrexate; Prednisone; Radioisotope Teletherapy; Radiotherapy; Radiotherapy Dosage; Vincristine | 1974 |
[Neuromeningeal irradiation during the treatment of acute lymphoblastic leukemia].
Topics: Acute Disease; Age Factors; Asparaginase; Carmustine; Central Nervous System; Child; Child, Preschool; Cobalt Radioisotopes; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Radioisotope Teletherapy; Radiotherapy Dosage; Time Factors; Vincristine | 1974 |
Over one and half years unmaintained remission in acute leukaemia.
Topics: Child; Common Cold; Hepatitis B; Humans; Influenza, Human; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mouth Diseases; Prednisone; Remission, Spontaneous; Time Factors; Ulcer; Vincristine | 1974 |
[Treatment of complications induced by chemotherapy of acute leukemias].
Topics: Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Antineoplastic Agents; Asparaginase; Blood Platelets; Blood Transfusion; Cytarabine; Daunorubicin; Drug Therapy, Combination; Hemorrhage; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Mercaptopurine; Methotrexate; Prednisone; Thrombocytopenia; Vincristine | 1974 |
[Two cases of acute childhood leukemia recovered from serious varicella infection (author's transl)].
Topics: Acute Disease; Chickenpox; Child, Preschool; Female; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate | 1972 |
[Some rare pulmonary complications in leukemic children during full haematological remission].
Topics: Adolescent; Asparaginase; Candidiasis; Child; Child, Preschool; Daunorubicin; Humans; Inflammation; Leukemia, Lymphoid; Lung Diseases, Fungal; Male; Methotrexate; Pulmonary Alveoli; Remission, Spontaneous; Vincristine | 1974 |
Cytological changes in the cerebrospinal fluid following intrathecal methotrexate treatment. I. Observations in adult meningeal leukemia.
Topics: Adolescent; Brain Neoplasms; Cell Count; Cell Nucleus; Cerebrospinal Fluid; Chromatin; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Male; Methotrexate; Middle Aged; Neurologic Manifestations | 1974 |
Management of childhood acute leukaemia.
Topics: Adolescent; Asparaginase; Blood Platelets; Blood Transfusion; Cephalosporins; Child; Child, Preschool; Drug Therapy, Combination; Female; Gentamicins; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisolone; Prognosis; Radiotherapy; Remission, Spontaneous; Vincristine | 1974 |
Response to combination therapy after relapse in childhood acute lymphocytic leukemia.
Topics: Adolescent; Anemia, Aplastic; Antineoplastic Agents; Central Nervous System; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Diarrhea; Drug Combinations; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Nausea; Pneumonia, Pneumocystis; Prednisone; Radiotherapy; Recurrence; Remission, Spontaneous; Stomatitis, Aphthous; Vincristine; Vomiting | 1972 |
Sequestration of PHA-responsive cells (T-lymphocytes) in the bone marrow of leukemic children undergoing long-term immunosuppressive therapy.
Topics: Adolescent; Bone Marrow Cells; Cells, Cultured; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; T-Lymphocytes; Thymidine; Tritium; Vincristine | 1972 |
Development of a combination chemotherapy program for adult acute leukemia: CAM and CAM-L.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Evaluation Studies as Topic; Female; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Remission, Spontaneous; Time Factors | 1973 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Guanosine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Phosphates; Thymidine; Tritium | 1973 |
Letter: Encephalopathy following CNS prophylaxis in childhood lymphoblastic leukemia.
Topics: Brain Diseases; Central Nervous System; Child; Folic Acid; Humans; Leucovorin; Leukemia, Lymphoid; Methotrexate | 1974 |
Clinical correlates of in vitro effect of methotrexate on acute leukemia blasts.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Biology; Cell Survival; Child; DNA, Neoplasm; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Purines; Remission, Spontaneous; Thymidine; Tritium | 1974 |
Löffler's endomyocardial fibrosis with eosinophilia in association with acute lymphoblastic leukemia.
Topics: Bone Marrow Examination; Child; Chromosome Aberrations; Drug Therapy, Combination; Endomyocardial Fibrosis; Eosinophilia; Heart Murmurs; Humans; Hydrocortisone; Leukemia, Lymphoid; Liver; Lymph Nodes; Male; Mercaptopurine; Methotrexate; Myocardium; Organ Size; Pneumonia, Pneumocystis; Prednisone; Recurrence; Tachycardia; Vincristine | 1974 |
Dissociation of lymphotoxin production and lymphocyte blast cell transformation in acute lymphoblastic leukemia after cessation of long-term immunosuppressive therapy.
Topics: Child, Preschool; Cyclophosphamide; DNA, Neoplasm; Female; Humans; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Lymphotoxin-alpha; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors | 1974 |
Treatment of the acute leukemias.
Topics: Adjuvants, Immunologic; Asparaginase; Bacterial Vaccines; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mycobacterium bovis; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1972 |
Expression of cell surface markers on T and B lymphocytes after long-term chemotherapy of acute leukemia.
Topics: Animals; Antibody Specificity; B-Lymphocytes; Cell Membrane; Child; Cyclophosphamide; Erythrocytes; Female; Fluorescent Antibody Technique; Goats; Humans; Immune Adherence Reaction; Immune Sera; Immunoglobulin G; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Sheep; T-Lymphocytes | 1973 |
The distribution of lymphocytes with T- and B-cell surface markers in human bone marrow.
Topics: Antibody Specificity; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Child; Cyclophosphamide; Drug Therapy, Combination; Fluorescent Antibody Technique; Humans; Immune Adherence Reaction; Immune Sera; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; T-Lymphocytes; Vincristine | 1974 |
Allogeneic marrow grafting in acute lymphoid leukemia during marrow remission.
Topics: Adolescent; Blood Cell Count; Bone Marrow Cells; Bone Marrow Transplantation; Child; Cobalt Radioisotopes; Cytogenetics; Female; Graft Rejection; Hematocrit; Histocompatibility Antigens; Humans; Leukemia, Lymphoid; Male; Methotrexate; Pneumonia, Pneumocystis; Postoperative Complications; Prognosis; Recurrence; Remission, Spontaneous; Transplantation, Homologous | 1973 |
Biochemical techniques for classification of leukemic cell types.
Topics: Cytarabine; Cytological Techniques; DNA, Neoplasm; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Phosphorus | 1973 |
Marrow transplantation for the treatment of acute leukemia using HL-A-identical siblings.
Topics: Acute Kidney Injury; Antilymphocyte Serum; Bone Marrow Cells; Bone Marrow Transplantation; Cyclophosphamide; Daunorubicin; Female; Graft Rejection; Graft vs Host Disease; Histocompatibility; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Pneumonia; Recurrence; Sepsis; T-Lymphocytes; Transplantation Immunology; Transplantation, Homologous | 1974 |
Prophylactic treatment of meningeal leukemia in children by intrathecal methotrexate.
Topics: Bone Marrow Examination; Brain Diseases; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Remission, Spontaneous; Vincristine | 1972 |
Immunologic rebound after cessation of long-term chemotherapy in acute leukemia.
Topics: Adolescent; Antibodies; Antibody Formation; Antibody-Producing Cells; Bone Marrow Examination; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Immunodiffusion; Immunoglobulins; Immunologic Memory; Immunosuppression Therapy; Leukemia, Lymphoid; Lymphocytes; Male; Mercaptopurine; Methotrexate; Orthomyxoviridae; Prednisone; Remission, Spontaneous; Vincristine | 1972 |
[Electroencephalographic and neurological changes in children with acute lymphoblastic leukemia following preventive intraspinal administration of amethopterin].
Topics: Brain Neoplasms; Child, Preschool; Electroencephalography; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate | 1972 |
Covariance analysis of censored survival data.
Topics: Age Factors; Child, Preschool; Dactinomycin; Humans; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Models, Biological; Nitrogen Mustard Compounds; Prognosis; Regression Analysis; Remission, Spontaneous; Statistics as Topic; Time Factors | 1974 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Mice; Neoplasm Transplantation; Prednisone; Procarbazine; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Transplantation, Homologous; Vinblastine; Vincristine | 1974 |
[Treatment of the intial stages of acute lymphoblastic leukemia by a combination of prednisone-vincristine-rubidomycin].
Topics: Adult; Antibiotics, Antineoplastic; Child; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1967 |
[Chemotherapy of leukemia].
Topics: Acute Disease; Antineoplastic Agents; Asparaginase; Chronic Disease; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1968 |
[A new combination of methotrexate and folinic acid for cancer treatment (acute leukemia and solid tumors)].
Topics: Agranulocytosis; Antineoplastic Agents; Breast Neoplasms; Female; Hemangiosarcoma; Hodgkin Disease; Humans; Kidney Neoplasms; Leucovorin; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Osteosarcoma; Pancreatic Neoplasms; Radiography; Rectal Neoplasms; Rhabdomyosarcoma; Testicular Neoplasms; Thrombocytopenia | 1969 |
[Is prognosis of acute lymphoblastic leukemia at a turning point?].
Topics: Antibody Formation; Antineoplastic Agents; Cyclophosphamide; Cytosine; Humans; Immunotherapy; Isoantibodies; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mycobacterium bovis; Prednisone; Prognosis; Vincristine | 1968 |
Pneumocystitis carinii pneumonia: percutaneous lung biopsy and review of literature.
Topics: Adolescent; Adult; Agammaglobulinemia; Amphotericin B; Anuria; Azathioprine; Biopsy; Bis-Trimethylammonium Compounds; Busulfan; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Pneumonia, Pneumocystis; Prednisone; Transplantation, Homologous; Vincristine | 1971 |
Clinical experience with L-asparaginase.
Topics: Adolescent; Adult; Aged; Asparaginase; Azaserine; Burkitt Lymphoma; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Escherichia coli; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Pancreatitis; Thrombocytopenia | 1970 |
Metabolism of leukocytes in a case of acute leukemia.
Topics: Autoradiography; Child; DNA; Female; Folic Acid; Humans; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Methotrexate; Prednisone; Thymidine; Tritium; Uridine; Vincristine; Vitamin B 12 | 1967 |
Paraproteinemia in a child with leukemia.
Topics: Agammaglobulinemia; Blood Protein Disorders; Blood Protein Electrophoresis; Bone Marrow Examination; Child, Preschool; Chromatography, DEAE-Cellulose; Complement System Proteins; Cyclophosphamide; Daunorubicin; Electrophoresis; Gels; Humans; Hypergammaglobulinemia; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin G; Lectins; Leukemia, Lymphoid; Lymphocyte Activation; Lymphocytes; Male; Mercaptopurine; Methotrexate; Prednisone; Starch; Ultracentrifugation; Vincristine | 1970 |
[Very long complete remissions of acute leukemia. 65 cases of acute leukemia that lasted longer than 4 years].
Topics: Acute Disease; Blood Platelets; Child; Child, Preschool; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Long-Term Care; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1970 |
[Drug therapy in hemoblastosis].
Topics: Antineoplastic Agents; Hematologic Diseases; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Multiple Myeloma; Polycythemia Vera; Prednisone; Vincristine; Waldenstrom Macroglobulinemia | 1968 |
Intensive treatment of acute leukaemia.
Topics: Acute Disease; Asparaginase; Humans; Infection Control; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Prednisolone; Vincristine | 1971 |
Preliminary result of a new protocol for the active immunotherapy of acute lymphoblastic leukaemia: inhibition of the immunotherapeutic effect by Vincristine or Adamantadine.
Topics: Adolescent; Adult; Age Factors; Aged; Amantadine; Asparaginase; BCG Vaccine; Child; Child, Preschool; Cytarabine; Humans; Hydrocortisone; Immunity, Active; Immunization, Passive; Immunotherapy; Infant; Leucovorin; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Radiotherapy, High-Energy; Remission, Spontaneous; Vincristine | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; Immunosuppressive Agents; Leukemia, Experimental; Leukemia, Lymphoid; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental | 1971 |
Chemotherapy of equine leukemia with amethopterin.
Topics: Animals; Horse Diseases; Horses; Leukemia, Lymphoid; Methotrexate | 1967 |
Infectious mononucleosis in acute lymphocytic leukemia.
Topics: Adolescent; Antibodies; Diagnosis, Differential; Humans; Infectious Mononucleosis; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine | 1965 |
Combinations of drugs in the treatment of acute leukemias.
Topics: Animals; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Drug Synergism; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mice; Vincristine | 1965 |
The very acute leukemias.
Topics: Adolescent; Adult; Aldehydes; Blood Cell Count; Bone Marrow; Cerebrospinal Fluid; Female; Fibrinogen; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Middle Aged; Vincristine | 1965 |
Long duration of complete remissions in acute leukemia.
Topics: Adult; Blood Transfusion; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis | 1965 |
Acute leukemia.
Topics: Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1966 |
Observations on viral, chemical, and radiation-induced myeloid and lymphoid leukemias in RF mice.
Topics: Alkylating Agents; Animals; Estrogens; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Radiation-Induced; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental; Retroviridae; Thymus Neoplasms; Urethane | 1966 |
Some problems in the management of leukaemia and lymphoma.
Topics: Antineoplastic Agents; Busulfan; Cyclophosphamide; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1966 |
Chemotherapy of the leukemic transformation of lymphosarcoma.
Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Prednisone | 1967 |
Continuous infusion of methotrexate in children with acute leukemia.
Topics: Blood Transfusion; Child; Child, Preschool; Drug Tolerance; Humans; Leukemia, Lymphoid; Methotrexate | 1967 |
Sequential therapy of acute leukemia in childhood.
Topics: Child; Child, Preschool; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone | 1967 |
Dihydrofolate reductase activity and deoxynucleoside incorporation into DNA of human leukocytes. Relation to methotrexate administration.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxyuridine; DNA; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Nucleosides; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
[Central nervous system infiltration in acute leukemias in children].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate | 1967 |
[Clinical course of leukemias with symptoms of the central nervous system in relation to treatment].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1967 |
[Chemotherapy of acute leukemia].
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Thrombocythemia, Essential; Vincristine | 1967 |
Treatment of the acute leukemias.
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1967 |
Methotrexate infusions and intensive supportive care in the management of children with acute lymphocytic leukemia: follow-up report.
Topics: Cyclophosphamide; Follow-Up Studies; Infusions, Parenteral; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Tablets; Urea; Vincristine | 1967 |
Combination chemotherapy of acute lymphocytic leukemia of childhood.
Topics: Adolescent; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Prednisone; Vincristine | 1967 |
Summary: recent advances in the treatment of acute leukemia and Burkitt's tumor.
Topics: Antineoplastic Agents; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1967 |
A study of "total therapy" of acute lymphocytic leukemia in children.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1968 |
Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.
Topics: Chromatography; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lymphocytes; Methotrexate; Temperature | 1968 |
Acute leukaemia 1959-64: factors affecting prognosis.
Topics: Blood Cell Count; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Female; Humans; Leukemia; Leukemia, Lymphoid; Liver; Male; Mercaptopurine; Methotrexate; Organ Size; Prednisone; Prognosis; Spleen; Triethylenemelamine; Vincristine | 1968 |
Cyclic chemotherapy in childhood acute leukaemia.
Topics: Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1968 |
[Life expectancy of hemoblastosis patients].
Topics: Adrenal Cortex Hormones; Adult; Antimetabolites; Antineoplastic Agents; Blood Transfusion; Child; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Plasmacytoma; Prednisone; Vincristine | 1966 |
Induction of remission in childhood leukemia with vincristine and 6-mercaptopurine and methotrexate. Administration in sequence after prednisone.
Topics: Bone Marrow; Child; Child, Preschool; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1968 |
[Effects of the reinduction method in the course of treatment of acute lymphoblastic leukemia].
Topics: Adult; Antibiotics, Antineoplastic; Child; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine | 1968 |
[Hypogammaglobulinemias associated with methotrexate treatment in the course of lymphoblastic leukemia in remission].
Topics: Agammaglobulinemia; Child, Preschool; Humans; Leukemia, Lymphoid; Male; Methotrexate | 1968 |
[Clinical and hematologic complete remissions of blastic leukoses in adults].
Topics: Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisolone | 1967 |
[Morphological and quantitative-cytochemical changes in normal human bone marrow cells due to cytostatics].
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Child; Child, Preschool; DNA; Erythropoiesis; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Vincristine | 1967 |
[Desoxyribonucleic acid distribution pattern in acute leukemia in childhood].
Topics: Bone Marrow Examination; Child; Child, Preschool; Cyclophosphamide; Densitometry; DNA, Neoplasm; Female; Histocytochemistry; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Photometry; Prednisone; Vincristine | 1967 |
[Current treatment of acute lymphoblastic leukemia: effects of the reinduction method].
Topics: Adolescent; Antineoplastic Agents; Child; Drug Synergism; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methods; Methotrexate; Prednisone; Vincristine | 1967 |
Treatment of acute leukemia.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Daunorubicin; Female; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Thioguanine; Time Factors; Vincristine | 1968 |
Induction of remission in acute leukemia with prednisone and intravenous methotrexate.
Topics: Blood Cell Count; Bone Marrow Examination; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Ulcer | 1968 |
[Effect and istribution of methotrexate in the human organism during leukemia treatment].
Topics: Adolescent; Adult; Female; Humans; Injections, Intravenous; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine Kinase | 1968 |
Drugs in the treatment of leukemia.
Topics: Asparaginase; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Pipobroman; Prednisolone; Vincristine | 1968 |
[Recent acquisitions in treatment of acute leukemias].
Topics: Adult; Aminopterin; Antineoplastic Agents; Child; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1967 |
[Treatment of acute childhood leukemia].
Topics: Age Factors; Antineoplastic Agents; Cyclophosphamide; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Paramethasone; Prognosis; Sex Factors; Vincristine | 1968 |
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis.
Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance | 1969 |
Enzyme activities and deoxynucleoside utilization of leukemic leukocytes in relation to drug therapy and resistance.
Topics: Chronic Disease; Cyclophosphamide; Deoxyuridine; DNA; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Leukocytes; Ligases; Mercaptopurine; Methotrexate; Nucleosides; Nucleotides; Phosphotransferases; Tetrahydrofolate Dehydrogenase; Thymidine Kinase | 1969 |
[Clinical-hematological findings in 58 acute leukemias].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Blood Platelets; Child; Female; Hemoglobinometry; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Methotrexate; Middle Aged; Time Factors | 1969 |
[Acute lymphoblastic leukemia].
Topics: Blood Transfusion; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1969 |
[Case of acute fatal leukemia in a child, complicated by chickenpox].
Topics: Adrenal Cortex Hormones; Bone Marrow Examination; Chickenpox; Child; Death, Sudden; Female; Humans; Leukemia, Lymphoid; Methotrexate | 1968 |
[Current status of the management of acute leukemias].
Topics: Acute Disease; Adult; Child, Preschool; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1968 |
[Chimiotherapy of cancers (operational research of its efficiency and its place in therapeutic strategy of neoplasic diseases)].
Topics: Agranulocytosis; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Daunorubicin; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Methotrexate; Neoplasms; Neoplastic Cells, Circulating; Prednisone; Vinblastine; Vincristine | 1969 |
Pulmonary disease complicating intermittent therapy with methotrexate.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Hypersensitivity; Eosinophils; Female; Granuloma; Humans; Leukemia, Lymphoid; Leukocyte Count; Lung Diseases; Male; Methotrexate; Radiography | 1969 |
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1969 |
Proliferative potential of out-of-cycle leukaemic cells.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Humans; Leukemia, Lymphoid; Methotrexate; Thymidine; Tritium | 1969 |
Methotrexate therapy and pulmonary disease.
Topics: Adolescent; Child; Female; Humans; Leukemia, Lymphoid; Lung Diseases; Methotrexate; Prednisone | 1969 |
[Association of radio- and chemotherapy in a new method of treating leukemic meningopathy].
Topics: Child, Preschool; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Meningitis; Methotrexate; Radiotherapy Dosage | 1969 |
[Modern aspects of treatment of acute leukemia].
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Child; Female; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone | 1968 |
Formal discussion of J. H. Burchenal's paper, "Success and failure in present chemotherapy and the implications of asparaginase".
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Vincristine | 1969 |
CNS leukemia mimicking multifocal leukoencephalopathy.
Topics: Brain Diseases; Central Nervous System Diseases; Child, Preschool; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Male; Methotrexate; Spinal Puncture | 1970 |
Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission.
Topics: Calcinosis; Child; Child, Preschool; Female; Fractures, Spontaneous; Humans; Leukemia, Lymphoid; Male; Methotrexate; Osteoporosis | 1970 |
Pneumonia and methotrexate.
Topics: Acute Disease; Adult; Drug Hypersensitivity; Female; Humans; Leukemia, Lymphoid; Methotrexate; Pneumonia; Prednisone | 1970 |
Cytosine arabinoside administered intrathecally in cerebromeningeal leukemia.
Topics: Adolescent; Brain Diseases; Central Nervous System; Child; Cytarabine; Diagnosis, Differential; Electroencephalography; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone | 1970 |
[Clinical hematology and evolution of acute lymphoid leukemia subjected to fractionated antiblastic therapy (1962-1966)].
Topics: Adolescent; Adult; Age Factors; Aminopterin; Blood Cell Count; Blood Cells; Child; Cyclophosphamide; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1969 |
Studies on the use of "prophylactic" intrathecal amethopterin in childhood leukemia.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Leukocytes; Male; Mercaptopurine; Methotrexate; Prednisone; Spinal Puncture; Vincristine | 1970 |
Urinary aminoimidazolecarboxamide levels in children with acute leukemia.
Topics: Blood Cell Count; Blood Cells; Blood Platelets; Bone Marrow Cells; Bone Marrow Examination; Child; Female; Humans; Imidazoles; Indicators and Reagents; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Neoplasm Recurrence, Local | 1970 |
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A).
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Neurologic Manifestations; Prednisone; Prognosis; Vincristine | 1970 |
[Use of intrathecal methotraxate in neurological manifestations due to acute leukemia].
Topics: Adolescent; Adult; Child, Preschool; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Neurologic Manifestations | 1968 |
The treatment of acute lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Asparaginase; Blood Platelets; Bone Marrow Cells; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Synergism; Hemorrhage; Humans; Infections; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Mice; Prednisone; Prognosis; Thrombocytopenia; Vincristine | 1970 |
Intrathecal cytotoxic treatment of cerebrospinal leukaemia through a Rickham reservoir.
Topics: Adolescent; Blood-Brain Barrier; Cerebrospinal Fluid; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged | 1970 |
Perturbation of generation cycle of human leukemic blast cells by cytostatic therapy in vivo: effect of corticosteroids.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; DNA; Female; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Methotrexate; Methylprednisolone; Microscopy, Electron; Middle Aged; Mitosis; Prednisone; Spectrophotometry; Thymidine; Tritium; Vincristine | 1970 |
The potentiality of out-of-cycle acute leukemic cells to synthesize DNA.
Topics: Adult; Aged; Autoradiography; Child; Cyclophosphamide; Daunorubicin; DNA Replication; Female; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Prednisone; Radiation Effects; Thymidine; Tritium; Ultraviolet Rays; Vincristine | 1970 |
Prognosis of acute leukemia (continued).
Topics: Child; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Prognosis; Vincristine | 1971 |
Proximal tubular hypertrophy in a case of acute leukemia of childhood: a study by microdissection.
Topics: Acute Disease; Child, Preschool; Humans; Hypertrophy; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone | 1970 |
Therapy of acute leukemia.
Topics: Adolescent; Animals; Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Daunorubicin; Disease Models, Animal; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mice; Remission, Spontaneous; Vincristine | 1970 |
Five-year follow-up of "total therapy" of childhood lymphocytic leukemia.
Topics: Administration, Oral; Antimetabolites; Central Nervous System; Child; Child, Preschool; Cyclophosphamide; Female; Follow-Up Studies; Humans; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Radiation Effects; Sex Factors; Time Factors; Vincristine | 1971 |
[Treatment of acute leukemia].
Topics: Acute Disease; Adolescent; Adult; Antibiotics, Antineoplastic; Antilymphocyte Serum; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Synergism; Female; Humans; Immunotherapy; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1970 |
[Cytologic study of the cerebrospinal fluid in leukemia patients with neurologic symptoms].
Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Methotrexate | 1971 |
[SDV (Salvioli's diffusing antitubercular vaccine) in immunotherapeutic use in acute leukemias in childhood].
Topics: BCG Vaccine; Child, Preschool; Cyclophosphamide; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate | 1971 |
[Acute pulmonary complications following intraspinal injection of cytostatic drugs].
Topics: Child; Child, Preschool; Cytarabine; Humans; Injections, Spinal; Leukemia, Lymphoid; Lung; Male; Methotrexate; Pulmonary Edema; Respiratory Insufficiency; Spinal Cord | 1970 |
[Studies on the mechanism of action of methotrexate on blast cells in acute leukemia].
Topics: Cell Division; DNA Replication; Humans; Leukemia, Lymphoid; Methotrexate | 1970 |
[Fatal development of infectious hepatitis in an infant in a state of remission from acute leukemia].
Topics: Child; Hepatitis A; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate | 1970 |
Daunorubicin treatment of methotrexate pneumonia.
Topics: Adolescent; Adult; Child, Preschool; Daunorubicin; Humans; Injections, Intramuscular; Injections, Intravenous; Leukemia, Lymphoid; Male; Methotrexate; Pneumonia | 1971 |
[Cytosine arabinoside in the therapy of acute leukoses].
Topics: Adolescent; Adult; Child; Cytarabine; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone | 1971 |
[Ocular symptomatology associated with acute leukemia].
Topics: Adrenal Cortex Hormones; Central Nervous System Diseases; Eye Diseases; Facial Nerve; Humans; Leukemia, Lymphoid; Methotrexate; Oculomotor Nerve; Optic Nerve; Papilledema; Retinal Detachment; Retinal Hemorrhage; Retinitis; Trochlear Nerve; Uveitis | 1968 |
[Treatment of acute leukemias with L-asparaginase. Preliminary results].
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Asparaginase; Child; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Prednisone; Vincristine | 1971 |
[Effects of the method of reinduction during the treatment of acute lymphoblastic leukemia].
Topics: Adult; Child; Child, Preschool; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methods; Methotrexate; Prednisone; Vincristine | 1971 |
Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.
Topics: Adult; Aged; Animals; Biological Transport; Cell Line; Chemical Precipitation; Chromatography; Chromatography, Gel; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid Antagonists; Humans; Hydroxyapatites; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Mice; Quaternary Ammonium Compounds; Quinazolines; Spectrophotometry; Sulfates; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1970 |
[Current problems in the treatment of malignant blood diseases].
Topics: Cyclophosphamide; Drug Synergism; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone | 1971 |
Serologic diagnosis of systemic candidiasis in patients with acute leukemia.
Topics: Adult; Agglutination Tests; Amphotericin B; Anti-Bacterial Agents; Candida; Candidiasis; Child; Cyclophosphamide; Cytarabine; Evaluation Studies as Topic; False Negative Reactions; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitrosourea Compounds; Precipitin Tests; Prednisone; Serologic Tests; Vinblastine; Vincristine | 1971 |
Observations on the plasma amino acids of patients with acute leukemia.
Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine | 1971 |
[Progress in the therapy of leukoses].
Topics: Antineoplastic Agents; Azathioprine; Busulfan; Chlorambucil; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mannitol; Methotrexate; Mitomycins; Triethylenemelamine; Vincristine | 1970 |
Therapy of acute leukemia with drug combinations which include asparaginase.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Child; Child, Preschool; Cytarabine; Female; Glutamine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Remission, Spontaneous; Vincristine | 1971 |
[Metastasizing ganglioneuroblastoma simulating acute leukemia].
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Antineoplastic Agents; Bone Neoplasms; Bone Resorption; Child, Preschool; Cyclophosphamide; Diagnosis, Differential; Diagnostic Errors; Femoral Neoplasms; Ganglioneuroma; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplastic Cells, Circulating; Norepinephrine; Radiography; Splenic Neoplasms; Vincristine | 1970 |
Synchronization and recruitment in acute leukemia.
Topics: Adult; Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Child; Culture Techniques; Cyclophosphamide; Cytarabine; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Exchange Transfusion, Whole Blood; Humans; Hydrocortisone; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Mitosis; Thymidine; Tritium; Vincristine | 1971 |
[Comparative evaluation of various methods of treating acute leukemia].
Topics: Adolescent; Cyclophosphamide; Daunorubicin; Female; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Vincristine | 1971 |
Hyperleukocytosis before the beginning of treatment in acute leukaemia in children and its subsequent repetition at the onset of relapses.
Topics: Acute Disease; Antibiotics, Antineoplastic; Bone Marrow Examination; Child; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Leukocytosis; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Recurrence; Vincristine | 1970 |
Lymphocyte transformation in patients with acute lymphoblastic leukaemia.
Topics: Acute Disease; BCG Vaccine; Humans; Lectins; Leukemia, Lymphoid; Lymphocyte Activation; Methotrexate; Remission, Spontaneous | 1971 |
[Therapy of acute leukemia. 4. Remission induction and remission maintenance therapy].
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Remission, Spontaneous; Vincristine | 1971 |
[Experiences in the treatment of immature cell leukemias with cytosine arabinoside and daunorubidomycin].
Topics: Adolescent; Adult; Aged; Agranulocytosis; Allopurinol; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Blood Transfusion; Cytarabine; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Muramidase; Nausea; Prednisolone; Thrombocytopenia; Vincristine | 1971 |
[Treatment of acute leukemia in adults].
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytosine Nucleotides; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1971 |
Massive cerebral Aspergillus abscess in a leukemic child. Case report.
Topics: Aspergillosis; Brain; Brain Abscess; Child, Preschool; Cyclophosphamide; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Vincristine | 1971 |
Clinical note: allergic reaction to daunomycin (NSC-82151).
Topics: Adolescent; Angioedema; Daunorubicin; Drug Hypersensitivity; Female; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Urticaria; Vincristine | 1970 |
Selecting drug regimens in human leukemia.
Topics: Antineoplastic Agents; Cell Membrane Permeability; Child; Cyclophosphamide; Cytarabine; Drug Combinations; Drug Resistance; Follow-Up Studies; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Nucleotides; Prednisone; Prognosis; Vincristine | 1971 |
DNA synthesis in leukemic cells under the action of cytotoxic agents in vitro and in vivo.
Topics: Adult; Aged; Antineoplastic Agents; Cells, Cultured; Cytarabine; Daunorubicin; DNA, Neoplasm; Female; Glucocorticoids; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Prognosis; Thymine Nucleotides; Tritium | 1971 |
Prediction of methotrexate responsiveness of tumors in man.
Topics: Deoxyuridine; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Prognosis; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1971 |
Pericardial involvement during remission in acute leukaemia.
Topics: Acute Disease; Allopurinol; Bone Marrow Examination; Child; Digitalis Glycosides; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pericardium; Prednisone; Radiography; Remission, Spontaneous; Vincristine | 1971 |
Treatment of acute leukemia with L-asparaginase--preliminary results on 84 cases.
Topics: Acute Disease; Asparaginase; Asparagine; Blood Coagulation Disorders; Cells, Cultured; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Daunorubicin; Humans; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver Function Tests; Methotrexate; Prednisone; Valine; Vincristine | 1970 |
[Cytology of cerebrospinal fluid in immature-cell leukemias].
Topics: Adult; Child, Preschool; Cytodiagnosis; Diagnosis, Differential; Female; Humans; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Male; Meningism; Methods; Methotrexate | 1971 |
Comparison of CNS-leukaemia in children with acute leukaemia, induced either with rubidomycin or L-asparaginase.
Topics: Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Neoplasm Metastasis; Prednisolone; Remission, Spontaneous; Vincristine | 1971 |
Active immunotherapy in the treatment of experimental leukemias and acute lymphoblastic leukemia in man.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Animals; BCG Vaccine; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Transfusion; Mercaptopurine; Methotrexate; Mice; Middle Aged; Neoplasm Transplantation; Prednisone; Radiation Effects; Transplantation, Homologous; Vincristine | 1970 |
Formal discussion: the clinical pharmacology of anti-leukemia agents.
Topics: Anilides; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Prednisone; Urethane; Vincristine | 1965 |
Absence of neurotoxicity following massive intrathecal administration of methotrexate. Case report.
Topics: Child, Preschool; Female; Humans; Injections, Spinal; Leucovorin; Leukemia, Lymphoid; Methotrexate; Nervous System | 1967 |
Successful treatment of pneumocystis carinii in an immunologically deficient acute lymphatic leukemia patient.
Topics: Adolescent; Agammaglobulinemia; Amidines; Anesthetics, Local; Antineoplastic Agents; Antiprotozoal Agents; Humans; Immunoglobulin G; Immunoglobulin M; Immunologic Deficiency Syndromes; Leukemia, Lymphoid; Male; Methotrexate; Pneumonia, Pneumocystis | 1969 |
Unusual complications of pentamidine in the treatment of Pneumocystis carinii pneumonia.
Topics: Acute Kidney Injury; Amidines; Autopsy; Blister; Blood Glucose; Child, Preschool; Cytoplasm; Epithelium; Female; Humans; Hyperglycemia; Leukemia, Lymphoid; Methotrexate; Nitrogen; Penicillin G; Pneumonia, Pneumocystis; Stevens-Johnson Syndrome; Sulfonic Acids; Uremia | 1970 |
Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors.
Topics: Adolescent; Adult; Aged; Carcinoma, Squamous Cell; Child, Preschool; Choriocarcinoma; Chorionic Gonadotropin; Female; Humans; Infusions, Parenteral; Injections, Intravenous; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Methotrexate; Middle Aged; Pregnancy; Teratoma; Testicular Neoplasms | 1970 |
[Operational procedure of antineoplastic chemotherapy by administering high doses of an antimetabolite and its antidote].
Topics: Antidotes; Female; Hodgkin Disease; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Neoplasms | 1971 |
Toxic and therapeutic effects of methotrexate-folinic acid (Leucovorin) in advanced cancer and leukemia.
Topics: Breast Neoplasms; Choriocarcinoma; Female; Head; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pregnancy; Remission, Spontaneous; Uterine Cervical Neoplasms | 1971 |
Elevation of thymidylate synthetase activity in CCRF-CEM cells.
Topics: Cell Line; Cells, Cultured; Child; Deoxyuridine; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Methotrexate; Methyltransferases; Thymidine; Uracil Nucleotides | 1971 |
Treatment of adult leukemia with L-asparaginase (NSC-109229).
Topics: Adolescent; Adult; Aged; Allopurinol; Anaphylaxis; Asparaginase; Blood Coagulation Disorders; Cytarabine; Daunorubicin; Drug Hypersensitivity; Female; Fever; Gastrointestinal Hemorrhage; Hallucinations; Humans; Hyperglycemia; Injections, Intravenous; Jaundice; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver; Male; Mercaptopurine; Methotrexate; Middle Aged; Oral Hemorrhage; Prednisone; Thioguanine; Uremia; Vincristine; Vomiting | 1971 |
Complication of methotrexate-maintained remission in lymphoblastic leukemia.
Topics: Ampicillin; Bone Marrow Diseases; Child; Cloxacillin; Female; Humans; Inhalation; Injections, Intramuscular; Leucovorin; Leukemia, Lymphoid; Lung; Methotrexate; Pneumonia; Prednisone; Remission, Spontaneous; Vincristine | 1971 |
Evidence for two molecular species of dihydrofolate reductase in amethopterin resistant and sensitive cells of the mouse leukemia L4946.
Topics: Animals; Antibodies; Chloromercuribenzoates; Chromatography, Gel; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Molecular Weight; Sodium Chloride; Tetrahydrofolate Dehydrogenase | 1970 |
Combinations, schedules, and new agents for the chemotherapy of acute leukemia.
Topics: Acute Disease; Adult; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Nitroso Compounds; Prednisone; Urea; Vincristine | 1970 |
Stimulation by pteridines of the uptake of amethopterin by human lymphocytes.
Topics: Aniline Compounds; Biological Transport; Carbon Isotopes; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Pteridines; Stimulation, Chemical; Triamterene | 1968 |
Methotrexate induced hepatitis in childhood leukemia.
Topics: Aminopterin; Biopsy; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Liver Function Tests; Male; Methotrexate; Spironolactone | 1965 |
New treatment schedule with improved survival in childhood leukemia. Intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. Acute leukemia group B.
Topics: Adolescent; Adult; Child; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Leukemia, Lymphoid; Male; Methotrexate; Mortality; Prednisone; Vincristine | 1965 |
Hypercalcemia associated with leukemia.
Topics: Cerebrospinal Fluid; Diagnosis, Differential; Female; Humans; Hypercalcemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Middle Aged; Neurologic Manifestations; Prednisone | 1966 |
Cerebrospinal fluid perfusion for central nervous system neoplasms.
Topics: Cerebral Ventricle Neoplasms; Cerebrospinal Fluid; Chemotherapy, Cancer, Regional Perfusion; Electrolytes; Humans; Inulin; Leukemia, Lymphoid; Methotrexate; Spinal Neoplasms; Subarachnoid Space | 1966 |