methotrexate has been researched along with Innate Inflammatory Response in 329 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (13.98) | 18.7374 |
| 1990's | 20 (6.08) | 18.2507 |
| 2000's | 37 (11.25) | 29.6817 |
| 2010's | 131 (39.82) | 24.3611 |
| 2020's | 95 (28.88) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Al-Abed, Y; VanPatten, S | 1 |
| Akbarizadeh, AR; Batta, G; Behzadi, M; Borazjani, N; Brunel, JM; Digiorgio, C; Ghanbari, MM; Ghasemi, Y; Jarrahpour, A; Mohkam, M; Rad, JA; Sasanipour, M; Sepehri, S; Turos, E | 1 |
| Artigas, A; Blanch, L; Bringué, J; Camprubí-Rimblas, M; Guillamat-Prats, R; Martinez, ML; Torrents, E | 1 |
| Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R | 1 |
| Abdel All, MO; Abdelaleem, OO; Abdelmeguid, EA; Eldosoki, DE; Elsayed, RM; Mahmoud, RH; Mohammed, MA; Morsi, EM; Said, ES | 1 |
| Asci, H; Ciris, M; Erzurumlu, Y; Hasseyid, N; Ilhan, I; Pekgöz, S; Savran, M | 1 |
| Alfwuaires, MA | 1 |
| Abd El-Aal, SA; Arab, HH; Arafa, EA; Ashour, AM; Eid, AH; Mahmoud, AM | 1 |
| Kouvelas, D; Malliou, F; Manthou, ME; Pourzitaki, C; Poutoglidou, F; Saitis, A; Samoladas, E | 1 |
| Al Jabbouri, A; Al-Mutairi, S; Al-Naseem, A; Aldubaikhi, A; Alsaif, A; Hayre, A; Kahlar, N; Karam, M | 1 |
| Bruun, JM; Hundahl, MP; Kjolby, M; Kragstrup, TW; Mikkelsen, RR; Rodríguez-Carrio, J; Torp, CK | 1 |
| Bai, L; Lang, W; Li, H; Liu, H; Shi, Q; Wang, J; Wu, T; Zhang, H; Zhang, Z | 1 |
| Ahmed, S; Carsons, SE; De Leon, J; Kasselman, L; Reiss, AB; Teboul, I | 1 |
| Chen, S; Chen, Y; Liu, L; Liu, X; Yan, Y | 1 |
| Betsholtz, C; Etori, K; Hattori, K; Ikeda, K; Kasuya, T; Maezawa, Y; Nakajima, H; Nakamura, J; Ohtori, S; Shoda, J; Suto, A; Suzuki, K; Takemoto, M; Tanaka, S; Yokote, K | 1 |
| Allaart, CF; Boer, AC; Böhringer, S; Burgers, LE; Dakkak, YJ; de Jong, PHP; de Witt-Luth, ME; Huizinga, TWJ; Kok, MR; Krijbolder, DI; Molenaar, ETH; Niemantsverdriet, E; Park, YJ; van der Helm-van Mil, AHM; van Dijk, BT; Verstappen, M; Visser, K | 1 |
| Mathieu, S; Sellam, J; Soubrier, M; Tournadre, A | 1 |
| Hu, L; Liu, R; Zhang, L | 1 |
| Han, Y; Jin, J; Wang, Z; Wu, F | 1 |
| Bayav, İ; Caglayan, C; Genç, A; Gür, C; Kandemir, FM; Varışlı, B | 1 |
| Aluko, A; Ranganathan, P | 1 |
| Basilico, R; Breda, L; Cafarotti, A; Chiarelli, F; David, D; Di Battista, C; Di Donato, G; Lapergola, G; Marcovecchio, ML; Marsili, M; Pelliccia, P | 1 |
| Cifuentes-González, C; de-la-Torre, A; Peña-Pulgar, LF; Pineda-Sierra, JS; Rojas-Carabali, W | 1 |
| Aubin, F; Gallais-Sérézal, I; Toussirot, E | 1 |
| Babalic, FCA; Banciu, CD; Borza, C; Caraba, AE; Chelu, SC; Gurban, CV; Ilie Rosca, C; Kundnani, NR; Marius, P; Mederle, OA; Popa, MD; Sharma, A | 1 |
| Arias-de la Rosa, I; Barbarroja, N; Collantes-Estévez, E; Cuesta-López, L; López-Pedrera, C; Pérez-Sánchez, C; Ruiz-Ponce, M | 1 |
| Back, W; Jeong, M; Jung, Y; Kang, J; Kim, D; Kim, H; Lee, SH; Park, JH; Sailor, MJ; Yoon, J | 1 |
| Feng, X; Liu, N; Liu, Y; Wang, Z; Zhang, M; Zhang, X; Zhao, D | 1 |
| Abukhalil, MH; Al-Khawalde, AAA; Aladaileh, SH; Alanezi, AA; Alaryani, FS; Alasmari, F; Aldal'in, HK; Alfwuaires, MA; Algefare, AI; Althunibat, OY; Jghef, MM; Karimulla, S | 1 |
| Bauerová, K; Chrastina, M; Czigle, S; Pašková, Ľ; Poništ, S; Švík, K; Tóth, J; Vyletelová, V | 1 |
| Edwards Mayhew, RG; Leslie, L; Li, T; McCann, P; Palestine, AG; Strong Caldwell, A | 1 |
| Al-Kindi, S; Anthony, DD; Bej, T; Burant, C; Damjanovska, S; Gad, I; Kostadinova, L; Kowal, CM; Lange, A; Mattar, M; Shive, C; Siddiqui, H; Singer, N; Syed, S; Wilson, B; Yousif, P; Zidar, DA | 1 |
| Kawali, A; Mahendradas, P; Sanjay, S; Shetty, R; Singh, Y; Yathish, GC | 1 |
| Barakat, MK; Ismail, CA; Rafik, ST; Shalaby, TI; Zeitoun, TM | 1 |
| Chen, T; Cui, Z; Huang, B; Li, Q; Liang, Q; Liu, Y; Tian, J; Wang, C; Xu, H; Zhang, W | 1 |
| Bartov, N; Dahan, T; Halperin, D; Katzenell, U | 1 |
| Gao, F; Li, D; Qian, Y; Song, H; Xiao, J; Zhang, M; Zhang, Y; Zhao, C | 1 |
| Chang, TY; Chang, YH; Chen, YC; Chen, YT; Chin, YF; Chu, JW; Hsieh, PS; Hsu, HL; Hsu, NY; Hsu, SC; Hsu, YC; Huang, CH; Huang, YW; Hung, YJ; Lee, CY; Lee, JY; Li, TN; Lin, CH; Lin, WC; Liu, PC; Liu, YC; Luo, YC; Pathak, N; Tsai, HP; Tzou, SC; Wang, JY; Wang, LH; Wu Lee, YH; Wu, HL; Yang, CM; Yang, HJ; Yang, JM | 1 |
| Fu, D | 1 |
| El-Kadem, AH; El-Mahdy, NA; El-Shitany, NAE; Mohammedsaleh, ZM; Waly, OM | 1 |
| Cheng, IT; Cheung, TT; Ho, CT; Kwok, KY; Lam, SH; Lam, TO; Lao, VW; Lee, JM; Lee, KL; Mok, CC; Ng, A; Pang, HT; Tam, LS; To, CH; Wan, MC; Yim, CW; Ying, SK | 1 |
| Busnelo Moreno, C; Colombo Barboza, GN; Colombo Barboza, MN; de Lima Batista Ribeiro Junior, M; Gonçalves Cruz, JC; Gouvêa Barioni, MF; Zotarelli-Filho, IJ | 1 |
| Alabarse, PVG; Bartikoski, BJ; do Espirito Santo, RC; Feist, E; Filippin, LI; Ghannan, K; Martinez-Gamboa, L; Silva, JMS; Teixeira, VON; Visioli, F; Xavier, RM | 1 |
| Acharya, AP; Mangal, JL; Suresh, AP; Swaminathan, SJ; Thumsi, A | 1 |
| Arafa, EA; Hassanein, EHM; Hussein, RM; Mohamed, WR | 1 |
| Amescua, G; Basu, S; Donthineni, PR; Kate, A; Quinones, VLP; Shanbhag, SS | 1 |
| Anonick, MV; Atukorale, PU; Bharadwaj, R; Brown, AR; Goldman, WE; Grimes, CL; Kane, GI; Kanneganti, TD; Lusi, CF; Mashayekh, S; Monahan, A; Nagar, A; Nandy, A; Okuda, K; Orzalli, MH; Paik, D; Silverman, N; Subbarao, M; Wodzanowski, KA | 1 |
| Deng, H; Du, T; Fan, J; Fu, C; Guo, L; Hao, L; Hou, X; Hu, H; Liu, F; Yang, L; Zhang, Q; Zhang, R | 1 |
| Kumar, R; Negi, S; Sharma, P; Tandel, N; Tyagi, RK | 1 |
| Badnikar, K; Krishnan, UM; Nayak, MM; Pahal, S; Rajendran, K; Subramanyam, DN; Vemula, PK | 1 |
| An, EK; Eom, HY; Hwang, J; Jin, JO; Kim, SJ; Kwak, M; Lee, JY; Lee, PC; Park, HB; Zhang, W | 1 |
| Esakkimuthukumar, M; Krishna Swaroop, A; Krishnan Namboori, PK; Nagarjuna, P; Patnaik, SK; Praveen, TK; Selvaraj, J | 1 |
| Arias-de la Rosa, I; Barbarroja, N; Collantes-Estévez, E; Cordoba, J; Cuesta-López, L; Escudero-Contreras, A; Gahete, MD; González, A; Leiva-Cepas, F; López-Pedrera, C; Lucendo, AJ; Navarro, P; Ortega, R; Pérez-Pampin, E; Pérez-Sánchez, C; Ruiz-Ponce, M | 1 |
| Schattner, A | 1 |
| Chen, CY; Chen, X; Chen, Y; Du, W; Gong, JS; He, ZH; Jin, L; Li, HM; Liu, YW; Luo, Y; Qian, YX; Rao, SS; Tan, YJ; Wan, TF; Wang, YY; Wang, Z; Wang, ZX; Xie, H; Yin, H; Zhu, H; Zou, JT | 1 |
| Fujii, Y; Kawanishi, M | 1 |
| Aslanlar, DA; Nurullahoglu Atalik, KE; Oz, M; Vişneci, EF | 1 |
| Christensen, AE; Mørtz, CG; Svendsen, SV; Zeraiq, L | 1 |
| Ates, T; Deger, M; Demir, E; Erdogan, KE; Kaplan, HM | 1 |
| Anand, P; Cho, TA; Gunaratne, S; Mukerji, SS; Thon, J; Venna, N | 1 |
| Jabs, DA | 1 |
| Asenso, J; Sun, W; Tang, H; Wang, B; Wang, C; Wang, Y; Wei, W; Wu, YJ; Xiao, F | 1 |
| Tschöpe, C; Van Linthout, S | 1 |
| Ahmad, HA; Baker, JF; Banerjee, S; Conaghan, PG; Durez, P; Emery, P; Ye, J; Østergaard, M | 1 |
| Targońska-Stępniak, B | 1 |
| Anderson, DR; Clemens, DL; Duryee, MJ; Hall, JH; Klassen, LW; Mikuls, TR; Thiele, GM; Zimmerman, MC | 1 |
| Bedoui, Y; Gasque, P; Giry, C; Guillot, X; Guiraud, P; Jaffar-Bandjee, MC; Ralandison, S; Sélambarom, J | 1 |
| Apparailly, F; Cren, M; Jorgensen, C; Louis-Plence, P; Mausset-Bonnefont, AL; Quentin, J; Vicente, R | 1 |
| Abd El-Twab, SM; Bin-Jumah, M; Hozayen, WG; Hussein, OE; Mahmoud, AM | 1 |
| Mosca, M; Panzuti, P; Pin, D | 1 |
| Cui, H; Garside, GB; Tang, D; Tao, S; Tao, Z; Wang, Y; Wu, J; Zeng, T; Zhang, L; Zou, B | 1 |
| Li, H; Li, X; Liu, J; Luo, S; Wan, Z; Wang, Y; Wu, X; Xie, X; Yang, M; Zhao, Z | 1 |
| Chen, C; Cheng, SB; Liu, YH; Wu, SL; Zhai, XJ | 1 |
| O'Neill, LAJ; Pålsson-McDermott, EM | 1 |
| Ridker, PM | 2 |
| Alqarni, AM; Zeidler, MP | 1 |
| Abd El-Twab, SM; Bin-Jumah, MN; Germoush, MO; Hozayen, WG; Hussein, OE; Mahmoud, AM | 1 |
| Hernandez, AV; Roman, YM; White, CM | 1 |
| Nath, A; Safavi, F | 1 |
| Goudarzi, M; Kalantar, H; Kalantar, M; Kalantari, H; Khodayar, MJ; Khorsandi, L; Roghani, M | 1 |
| Asano, T; Iguchi, A; Miyasho, T | 1 |
| Kremer, JM | 1 |
| Dellaripa, PF; Glynn, RJ; Paynter, NP; Ridker, PM; Solomon, DH; Sparks, JA; Xu, C | 1 |
| Agrawal, YO; Mahajan, HS; Mahajan, UB; Ojha, S | 1 |
| Ağgül, AG; Cellat, M; Güvenç, M; Kırbaş, A; Kuzu, M; Türk, E; Uyar, A | 1 |
| Bivik Eding, C; Enerbäck, C; Fekri, SZ; Sandin, C; Sigurdardottir, G; Verma, D | 1 |
| Cornel, JH; Hoogeveen, RM; Stroes, ESG | 1 |
| Alarifi, S; Albasher, G; Alfarraj, S; Alkhatani, S; Almeer, R; Alqahtani, WS; Dar, AA; Fehaid, A; Moneim, AA | 1 |
| Bedoui, Y; Gasque, P; Giry, C; Guiraud, P; Jaffar-Bandjee, MC; Selambarom, J; Septembre-Malaterre, A | 1 |
| Chen, J; Ding, H; Li, C; Wang, J; Xia, Z; Ye, J | 1 |
| Cai, Q; Ma, S; Pang, J; Xu, X; Zhang, B | 1 |
| Cregan, S; Cunningham, CC; Fearon, U; Floudas, A; McGarry, T; Orr, C; Veale, DJ; Wade, S | 1 |
| Baerwald, C; Nguyen, P | 1 |
| Boiardi, L; Casali, M; Cavallaro, A; Corte, G; Crescentini, F; Galli, E; Kuwert, T; Manger, B; Muratore, F; Rech, J; Roth, J; Salvarani, C; Schett, G; Schmidt, D; Schönau, V; Spaggiari, L; Tascilar, K; Uder, M; Versari, A | 1 |
| Chen, J; Cooper, D; Norling, LV | 1 |
| Abdullah, ST; Ahmed, I; Bag, S; Bhatt, S; Dhiman, S; Dogra, A; Gupta, D; Kumar, A; Nandi, U; Nehra, E; Sangwan, PL; Singh, G | 1 |
| Chouk, M; Demougeot, C; Prati, C; Verhoeven, F; Wendling, D | 1 |
| Furuta, S; Furuya, H; Iida, K; Ikeda, K; Iwamoto, T; Iwata, A; Kasuya, T; Kato, M; Kawakami, E; Kumagai, T; Mimura, N; Nakajima, H; Nishimura, N; Suga, K; Sugiyama, T; Suto, A; Suzuki, K; Tanaka, S | 1 |
| Hassanein, EHM; Hemeida, RAM; Khalaf, MM; Mohamed, WR; Shalkami, AS | 1 |
| Ahmed, MA; Ali, FEM; Hassanein, EHM; Kamel, EO | 1 |
| Abo-Youssef, AM; Hassan, MIA; Hemeida, RAM; Osman, AT; Sharkawi, SMZ | 1 |
| Laasonen, L; Leirisalo-Repo, M; Moilanen, E; Nieminen, R; Tuure, L; Vuolteenaho, K | 1 |
| Andres-Hernando, A; Cara-Fuentes, G; Garcia, GE; Johnson, RJ; Lanaspa, M; Leamon, CP; Lu, YJ; Miyazaki, M; Miyazaki-Anzai, S; Roncal-Jiménez, CA; Truong, LD | 1 |
| Abd El-Ghafar, OAM; Ali, FEM; Hassanein, EHM; Mohammedsaleh, ZM; Omar, ZMM; Rashwan, EK; Sayed, AM | 1 |
| Alim, MA; Bird, G; Haleagrahara, N; Hayes, L; Ketheesan, N; Miranda-Hernandez, S | 1 |
| Abd El-Twab, SM; Hozayen, WG; Hussein, OE; Mahmoud, AM | 1 |
| Amano, W; Hayashi, M; Kakimoto, K; Katsuda, Y; Kimoto, Y; Konishi, N; Shinozaki, Y; Taniai-Riya, E; Tanimoto, A; Toyoda, K; Yamamoto, Y | 1 |
| Ali, N; Hasan, SK; Majed, F; Nafees, S; Rashid, S; Shahid, A; Sultana, S | 1 |
| Bakr, AG; Khalifa, MMA; Osman, AT | 1 |
| Boehm, M; Hallenbeck, J; Hollander, MC; Ishii, H; Latour, LL; Lin, PC; Merchant, AS; Min, Y; Munasinghe, J; Ray-Choudhury, A; Xiao, Z; Yang, D; Yang, L | 1 |
| Abdo, M; Fekry, E; Makary, S | 1 |
| Bouziotis, P; Datseris, IE; Furenlid, LR; Kastis, GA; Papachristou, M; Stavrou, PZ; Xanthopoulos, S | 1 |
| Chen, S; Fan, S; Liu, G; Qin, A; Sun, X; Tang, P; Xie, Z; Zhang, J; Zhu, P | 1 |
| Chistiakov, DA; Grechko, AV; Melnichenko, AA; Myasoedova, VA; Orekhov, AN | 1 |
| Campos, RG; Cuevas, VD; Dominguez-Soto, Á; Fuentelsaz-Romero, S; González-Álvaro, I; Lamana, A; Montes, N; Municio, C; Pablos, JL; Puig-Kröger, A | 1 |
| Berti, E; Damiani, G; Fiore, M; Leone, S; Maraolo, AE | 1 |
| Benko, M; Bismuth, G; Blüml, S; Burkard, TR; Cavaco-Paulo, A; Charvet, C; Feuillet, V; Fischer, MB; Huppa, JB; Lager, F; Le Roux, D; Leksa, V; Machacek, C; Matsuyama, T; Mitulovic, G; Ohradanova-Repic, A; Platzer, R; Renault, G; Stockinger, H; Suchanek, M; Zlabinger, GJ | 1 |
| Fayez, AM; Moustafa, D; Zakaria, S | 1 |
| Cho, H; Choy, EH; Hashizume, M; John, MR; O'Mahony, A | 1 |
| Abraham, P; Isaac, B; Kota, R; Natarajan, K | 1 |
| Abdel-Aziz, AK; Abdel-Maged, AE; Aboulwafa, MM; Azab, SS; Gad, AM | 1 |
| Bell, T; Currier, JS; Daar, ES; Deeks, SG; Fichtenbaum, C; Havlir, D; Hsue, PY; Lederman, M; Ribaudo, HJ; Ridker, PM; Stein, JH; Tawakol, A; Yeh, E | 1 |
| Fang, K; Guan, X; Lin, H; Liu, J; Pang, Z; Ran, N; Wang, F; Wang, G; Wang, Z; Yuan, Y | 1 |
| Chen, X; Guo, Y; Huang, W; Körner, H; Wang, X; Wei, W; Wu, H; Zhang, P | 1 |
| Chang, CY; Chen, DY; Chen, HH; Chen, YM; Hsieh, CW; Lan, JL; Tang, KT; Yang, MC | 1 |
| Lorthois, I; Morin, S; Pouliot, R; Simard, M | 1 |
| Martin, U; Nolan, DF; O'Gradaig, D; Sheehy, C | 1 |
| Bakhit, S; Goudarzi, M; Kalantar, H; Kalantar, M; Kalantari, H; Khorsandi, L | 1 |
| Artornsombudh, P; Begum, H; Bhatt, NP; Daniel, E; Dreger, K; Foster, CS; Gangaputra, SS; Jabs, DA; Joffe, MM; Kempen, JH; Levy-Clarke, GA; Newcomb, CW; Nussenblatt, RB; Pujari, SS; Rosenbaum, JT; Sen, HN; Suhler, EB; Thorne, JE | 1 |
| Ikemura, M; Kusunoki-Nakamoto, F; Matsukawa, T; Miyagawa, T; Shibahara, J; Shimizu, J; Tanaka, M; Tsuji, S; Yamamoto, T | 1 |
| Allaart, CF; Giltay, EJ; Heimans, L; Huizinga, TW; Ronday, HK; Steup-Beekman, GM; van der Mast, RC; van Oosterhout, M; Visser, K; Wevers-de Boer, KV | 1 |
| Clearfield, M; Everett, BM; Glynn, RJ; Gupta, M; Hasan, AA; Libby, P; Macfadyen, J; Paynter, N; Pradhan, AD; Ridker, PM; Solomon, DH; Zaharris, E | 1 |
| Li, G; Li, L; Li, Y; Yu, C | 1 |
| Briones, TL; Woods, J | 1 |
| Amaravadi, L; Burkly, LC; Galluppi, GR; Kong, J; Wisniacki, N; Zhang, R; Zheng, TS | 1 |
| Barton, A; Chinoy, H; Griffiths, CE; Jani, M; Warren, RB | 1 |
| Chen, W; Herrero, LJ; Mahalingam, S; Rulli, NE; Sheng, KC; Taylor, A | 1 |
| Atteno, M; Caso, F; Caso, P; Costa, L; Darda, MA; Del Puente, A; Fiocco, U; Ortolan, A; Punzi, L; Ramonda, R; Scarpa, R | 1 |
| Hamada, K; Horie, T; Kakigawa, N; Sekine, S; Shitara, Y | 1 |
| Abotsi, WK; Ainooson, GK; Woode, E | 1 |
| Ciszak, L; Frydecka, I; Kosmaczewska, A; Swierkot, J; Szteblich, A; Wiland, P | 1 |
| Bremell, T; Forsblad-d'Elia, H; Geijer, M; Mörck, B; Pullerits, R | 1 |
| Gu, Y; Jin, B; Liu, W; Luo, Q; Qian, C; Shen, Y; Sun, Y; Tao, F; Wu, X; Xu, Q | 1 |
| Castro Cabezas, M; Hazes, JM; Klop, B; van Breukelen-van der Stoep, DF; van Zeben, D | 1 |
| Corondan, A; Devauchelle-Pensec, V; Ducourau, E; Goupille, P; Le Goff, B; Mulleman, D; Paintaud, G; Perdriger, A; Solau-Gervais, E; Ternant, D; Watier, H | 1 |
| Brown, L; Churton, S; Korman, NJ; Shin, TM | 1 |
| Bizzi, E; Bruzzese, V; Cassol, M; Diamanti, AP; Laganà, B; Massafra, U; Migliore, A | 1 |
| Arora, J; Blair, IA; Hammons, AL; Jochems, J; Summers, CM; Whitehead, AS; Zhang, S | 1 |
| Conway, R; Crowley, B; Cunnane, G; Doran, MF; O'Shea, FD | 1 |
| Alcocer, S; Bohorquez, D; de Morales, TR; Morón-Medina, A; Viera, N | 1 |
| DuHadaway, JB; Gilmour, S; Mandik-Nayak, L; Muller, AJ; Pigott, E; Prendergast, GC | 1 |
| Goldstein, M; Jo, D; Khalil, A; Kong, F; Pompa, T; Wetz, R | 1 |
| Byamba, D; Jee, H; Kim, DS; Kim, DY; Kim, SH; Kim, TG; Lee, MG; Lee, SK; Park, TY; Yang, SH | 1 |
| Acquaviva, A; Bauerova, K; Drafi, F; Gardi, C; Harmatha, J; Hradkova, I; Kuncirova, V; Mihalova, D; Nosal, R; Ponist, S | 1 |
| Acquaviva, A; Arezzini, B; Bauerova, K; Bezakova, L; Drafi, F; Gardi, C; Kuncirova, V; Mihalova, D; Nosal, R; Ponist, S; Vecchio, D | 1 |
| Jost-Brinkmann, PG; Meyer, P; Minden, K; Präger, TM; Radlanski, RJ; Rafayelyan, S | 1 |
| Dejaco, C; Duftner, C; Ficjan, A; Graninger, WB; Gretler, J; Gutierrez, M; Hermann, J; Husic, R; Lackner, A | 1 |
| Amano, W; Kimoto, Y; Matsuo, A; Matsushita, M; Noji, S; Nozawa, K; Ogawa, Y; Oki, C; Shinozaki, Y; Shiozaki, M; Tanimoto, A | 1 |
| Kirby, B; Ryan, C | 1 |
| Foulkes, AC; Warren, RB | 1 |
| Cronstein, BN; Mediero, A; Perez-Aso, M; Wilder, T | 1 |
| Al-Rashed, F; Bauer, A; Birdsey, GM; Boyle, JJ; Calay, D; Haskard, DO; Mason, JC; Morley, BJ; Mylroie, H; Randi, AM; Thornton, CC | 1 |
| Witte, T | 1 |
| Alponti, RF; Mendes, MT; Silveira, PF; Yamasaki, SC | 1 |
| Andrade, NP; Brenol, CV; Brenol, JC; da Chakr, RM; Laurindo, IM; Toni, M; Xavier, RM | 1 |
| Ahmed, RS; Arora, VK; Banerjee, BD; Khan, MA; Subramaneyaan, M | 1 |
| Araújo, TE; Borba, PB; da Silva, AI; de Araújo Júnior, RF; de Araújo, AA; de Souza, FH; Nogueira, AC; Saldanha, TS | 1 |
| Cure, E; Cure, MC; Kalkan, Y; Kirbas, A; Kizilkaya, B; Pergel, A; Sahin, OZ; Tumkaya, L; Yuce, S | 1 |
| Chiragh, S; Faisal, R; Popalzai, AJ | 1 |
| Audouin-Pajot, C; Bréhin, C | 1 |
| Tanaka, Y | 2 |
| Faisal, R; Jehangir, T; Shinwari, L | 1 |
| Forslind, K; Svensson, B | 1 |
| Boechat, AL; da Costa, AG; de Oliveira, CP; Guterres, SS; Malheiro, A; Pohlmann, AR; Tarragô, AM | 1 |
| Cordoba, R; Fernández-Sanz, G; Garcia Raso, A; Llamas, P; Monsalvo, S; Prieto, E; Puente, MC; Rodriguez-Pinilla, M; Serrano, C | 1 |
| Gautam, R; Gautam, S; Kaithwas, G; Rawat, JK; Saraf, SA; Singh, M | 1 |
| Bäcker, I; Flemmig, J; Furtmüller, PG; Lange, F; Leichsenring, A; Obinger, C | 1 |
| Schmidt, WA | 1 |
| Bachta, A; Kisiel, B; Raczkiewicz, A; Rękas, M; Tłustochowicz, M; Tłustochowicz, W | 1 |
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| Cronstein, BN; D'Eustachio, P; Delano, DL; Desai, A; Fernandez, P; Montesinos, MC; Wilder, T; Wiltshire, T | 1 |
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| Alvarez, C; Ferreira, A; Gatica, H; Goecke, IA; Henríquez, J; Molina, ML; Salas, K | 1 |
| Bank, I; Ben-Horin, S; Langevitz, P; Levi, Y; Livneh, A; Schiby, G; Tweezer-Zaks, N | 1 |
| Dick, AD; Hogan, A; Lee, R; Ramanan, AV; Sharma, S; Teoh, SC | 1 |
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| Ancona, E; Cadrobbi, R; Castagnaro, M; Cavicchioli, L; Cozzi, E; De Zan, G; Dedja, A; Hutabba, S; Ravarotto, L; Zappulli, V | 1 |
| Azuma, T; Hanami, K; Iwata, S; Nakayamada, S; Nawata, M; Saito, K; Tanaka, Y; Yamaoka, K | 1 |
| Cronstein, BN; Fernández, P; Montesinos, MC; Takedachi, M; Thompson, LF; Wilder, TF | 1 |
| Bergman, MJ; Hines, P; Maclean, R; Pincus, T; Raghupathi, K; Yazici, Y | 1 |
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| Brocke, U; Brüske-Hohlfeld, I; Hohlfeld, R; Schwartz, A; Toyka, KV | 1 |
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| Doroshow, JH; Gaasterland, DE; Hubbard, SP; Locker, GY; Myers, CE; Young, RC | 1 |
| Almeida, AP; Bayer, BM; Beaven, MA; Horakova, Z | 1 |
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| Cronstein, BN; Naime, D; Ostad, E | 2 |
| Cronstein, BN | 3 |
| Costa, MJ; Goodnight, JE; Perez, EA; Stewart, G | 1 |
| Blazek, B; Plevová, P | 1 |
| Chen, W; Li, S; Liu, B; Zhang, H | 1 |
| Wilke, WS | 1 |
| Balduini, CL; Battaglia, M; Da Prada, GA; Gibelli, N; Noris, P; Pavesi, L; Pedrazzoli, P; Perotti, C; Preti, P; Robustelli della Cuna, G; Salvaneschi, L; Torretta, L; Zibera, C | 1 |
| Kawauchi, M; Nakajima, J; Takamoto, S; Takeda, M | 1 |
| Barendsen, BC; Bruyn, GA; Houtman, PM; Speerstra, F; Stenger, AA; Van Leeuwen, MA; van Rijswijk, MH; Velthuysen, E | 1 |
| Harnett, AN; Mackay, HJ; Vasey, P; Williamson, EC | 1 |
| Egan, LJ; Leighton, JA; Lipsky, JJ; Mays, DC; Pike, MG; Sandborn, WJ; Tremaine, WJ; Zinsmeister, AR | 1 |
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| Bechara, GH; Dos Santos, RR; Leme, JG | 1 |
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| Kosmorsky, GS; Lowder, CY; Meisler, DM; Schmitt, MA; Shah, SS; Wilke, WS | 1 |
| Bethouart, M; Buchet-Bouverne, B; Crépin, G; Lecuru, F; Querleu, D; Vasquez, G | 1 |
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| Abbadessa, V; Avanzini, P; Carotenuto, M; Cavanna, L; Federico, M; Gobbi, PG; Leone, G; Lombardo, M; Moretti, G; Pitini, V | 1 |
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51 review(s) available for methotrexate and Innate Inflammatory Response
| Article | Year |
|---|---|
High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target.
Topics: Alarmins; Biomarkers; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Molecular Targeted Therapy; Pathogen-Associated Molecular Pattern Molecules | 2018 |
Mycophenolate versus Methotrexate in Non-infectious Ocular Inflammatory Disease: A Systematic Review and Meta-Analysis.
Topics: Enzyme Inhibitors; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Mycophenolic Acid; Retrospective Studies; Treatment Outcome | 2023 |
Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach.
Topics: Animals; Antibodies, Monoclonal, Humanized; Cardiovascular Diseases; Colchicine; Diabetes Mellitus, Type 2; Etanercept; Humans; Hydroxychloroquine; Immunomodulating Agents; Immunosuppression Therapy; Immunosuppressive Agents; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-1beta; Methotrexate; Sulfasalazine | 2022 |
Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis.
Topics: Antirheumatic Agents; Humans; Hydroxychloroquine; Inflammation; Interleukin-1; Methotrexate; Osteoarthritis; Pain; Quality of Life | 2022 |
Advance in bone destruction participated by JAK/STAT in rheumatoid arthritis and therapeutic effect of JAK/STAT inhibitors.
Topics: Arthritis, Rheumatoid; Bone Resorption; Humans; Inflammation; Janus Kinase Inhibitors; Janus Kinases; Methotrexate; Osteoclasts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; STAT Transcription Factors | 2022 |
Kidney function and renal resistive index in children with juvenile idiopathic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Child; Creatinine; Female; Humans; Inflammation; Kidney; Male; Methotrexate | 2023 |
The cardiometabolic conditions of psoriatic disease.
Topics: Arthritis, Psoriatic; Cardiovascular Diseases; Cytokines; Humans; Inflammation; Interleukin-17; Interleukin-23; Methotrexate; Psoriasis; Tumor Necrosis Factor-alpha | 2022 |
Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk.
Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Products; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Inflammation; Leflunomide; Liver Cirrhosis; Methotrexate; Non-alcoholic Fatty Liver Disease; Risk Factors | 2022 |
Non-biologic, steroid-sparing therapies for non-infectious intermediate, posterior, and panuveitis in adults.
Topics: Adult; Antirheumatic Agents; Azathioprine; Cyclosporine; Humans; Immunosuppressive Agents; Inflammation; Macular Edema; Methotrexate; Mycophenolic Acid; Panuveitis; Steroids; Tacrolimus | 2022 |
Necrotizing Scleritis and Rheumatoid Arthritis: A Clinical Case Report Supported by A Brief Review with Risk of Bias Analysis.
Topics: Arthritis, Rheumatoid; Female; Humans; Inflammation; Methotrexate; Middle Aged; Scleritis; Tumor Necrosis Factor Inhibitors | 2023 |
Role of topical and systemic immunosuppression in aqueous-deficient dry eye disease.
Topics: Azathioprine; Dry Eye Syndromes; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Inflammation; Methotrexate | 2023 |
Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Inflammation; Methotrexate; Mice | 2023 |
The Cardiovascular Burden of Rheumatoid Arthritis - Implications for Treatment.
Topics: Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors | 2023 |
The Quest for Antiinflammatory and Immunomodulatory Strategies in Heart Failure.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Atherosclerosis; Calgranulin A; Calgranulin B; Cytokines; Drug Development; Heart Failure; Humans; Immunologic Factors; Inflammation; Mesenchymal Stem Cell Transplantation; Methotrexate; NLR Family, Pyrin Domain-Containing 3 Protein; T-Lymphocytes, Regulatory; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2019 |
Relevance of the antioxidant properties of methotrexate and doxycycline to their treatment of cardiovascular disease.
Topics: Animals; Antioxidants; Atherosclerosis; Cardiovascular Diseases; Doxycycline; Humans; Inflammation; Lipid Peroxidation; Malondialdehyde; Methotrexate; Oxidative Stress; Reactive Oxygen Species | 2020 |
Methotrexate an Old Drug with New Tricks.
Topics: Adenosine; Alarmins; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cytokines; Folic Acid; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Matrix Metalloproteinases; Methotrexate; NF-kappa B; Polyamines; Prostaglandins; Reactive Oxygen Species | 2019 |
Targeting immunometabolism as an anti-inflammatory strategy.
Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Dimethyl Fumarate; Glycolysis; Humans; Immunomodulation; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Sirolimus | 2020 |
How does methotrexate work?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Line; Crohn Disease; Folic Acid; Humans; Inflammation; Janus Kinases; MAP Kinase Signaling System; Methotrexate; Psoriasis; Signal Transduction; STAT Transcription Factors | 2020 |
The Role of Suppressing Inflammation in the Treatment of Atherosclerotic Cardiovascular Disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Clinical Trials as Topic; Colchicine; Female; Humans; Immunity, Innate; Inflammation; Male; Methotrexate; Middle Aged; Treatment Outcome | 2020 |
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Etanercept; Heart Failure; Humans; Hydroxychloroquine; Inflammation; Methotrexate; Myocardial Infarction; Myocardial Ischemia; Risk Factors; Stroke Volume; Sulfasalazine | 2021 |
Methotrexate and cardiovascular risk in rheumatic diseases:A comprehensive review.
Topics: Animals; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Inflammation; Methotrexate; Oxidative Stress; Psoriasis | 2021 |
Potential of anti-inflammatory agents for treatment of atherosclerosis.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Atherosclerosis; Colchicine; Cyclooxygenase 2 Inhibitors; Cytokines; Humans; Inflammation; Leukotrienes; Methotrexate; Molecular Targeted Therapy; Phospholipase A2 Inhibitors; Signal Transduction | 2018 |
Liver Illness and Psoriatic Patients.
Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Inflammation; Liver; Liver Diseases; Methotrexate; Psoriasis | 2018 |
Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 2 Inhibitors; Female; Frontal Bone; Humans; Inflammation; Methotrexate; Middle Aged; Neoplasms, Muscle Tissue; Treatment Outcome | 2013 |
A meta-analysis of the role of p38 mitogen-activated protein kinase inhibitors in patients with active rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; p38 Mitogen-Activated Protein Kinases; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2013 |
The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Immunomodulation; Inflammation; Inflammatory Bowel Diseases; Methotrexate; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Cardiovascular risk in rheumatoid arthritis: how to lower the risk?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors; Risk Reduction Behavior; Tumor Necrosis Factor-alpha | 2013 |
Does treatment of psoriasis reduce the risk of cardiovascular disease?
Topics: Biomarkers; Cardiovascular Diseases; Humans; Inflammation; Inflammation Mediators; Interleukin-12; Interleukin-23; Methotrexate; Phototherapy; Psoriasis; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
Radiological outcomes in randomized controlled trials on biologic therapies for rheumatoid arthritis: a narrative review.
Topics: Abatacept; Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Biological Products; Certolizumab Pegol; Disease Progression; Etanercept; Humans; Immunoconjugates; Immunoglobulin Fab Fragments; Immunoglobulin G; Inflammation; Infliximab; Magnetic Resonance Imaging; Methotrexate; Polyethylene Glycols; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Rituximab; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
Rheumatoid myositis leading to acute lower extremity compartment syndrome: a case-based review.
Topics: Arthritis, Rheumatoid; Biopsy; Blood Sedimentation; Compartment Syndromes; Creatine Kinase; Edema; Female; Humans; Immunosuppressive Agents; Inflammation; Leg; Leukocytes, Mononuclear; Methotrexate; Middle Aged; Muscle, Skeletal; Muscular Atrophy; Myositis; Prednisone; Rheumatoid Factor | 2015 |
Psoriasis is a systemic disease with multiple cardiovascular and metabolic comorbidities.
Topics: Acitretin; Adipokines; Alcoholism; Antibodies, Monoclonal, Humanized; Cardiovascular Diseases; Comorbidity; Cyclosporine; Dermatologic Agents; Diabetes Mellitus; Fumarates; Humans; Immunosuppressive Agents; Inflammation; Metabolic Syndrome; Methotrexate; Obesity; Psoriasis; Risk Factors; Smoking; Tumor Necrosis Factor-alpha; Ustekinumab | 2015 |
Pharmacogenomics and the resulting impact on psoriasis therapies.
Topics: Acitretin; Cyclosporine; Cytokines; HLA-C Antigens; Humans; Immunosuppressive Agents; Inflammation; Keratolytic Agents; Methotrexate; Pharmacogenetics; Phototherapy; Polymorphism, Genetic; Precision Medicine; Psoriasis; Research Design; Tumor Necrosis Factor-alpha | 2015 |
Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Adhesion; Cell Movement; Cell Proliferation; Dendritic Cells; Gene Expression Regulation; Humans; Immune System; Inflammation; Joints; Methotrexate; Monocytes; RANK Ligand; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2015 |
Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside.
Topics: Arthritis, Rheumatoid; Humans; Inflammation; Janus Kinase 1; Janus Kinase 3; Methotrexate; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; STAT1 Transcription Factor; Translational Research, Biomedical; Tumor Necrosis Factor-alpha | 2015 |
[Paradigm shift in the treatment of rheumatoid arthritis by biologics].
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Design; Etanercept; Humans; Immunoglobulin G; Inflammation; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Rituximab; Tumor Necrosis Factor-alpha | 2008 |
Therapeutic targets for persistent airway inflammation in refractory asthma.
Topics: Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Cyclosporine; Drug Delivery Systems; Drug Resistance; Etanercept; Gold Compounds; Humans; Immunoglobulin G; Inflammation; Leukotriene Antagonists; Methotrexate; Omalizumab; Phosphodiesterase Inhibitors; Receptors, Tumor Necrosis Factor; Respiration Disorders | 2010 |
[Lipid profile and cardiovascular risk in patients with rheumatoid arthritis: Effect of the disease and of drug therapy].
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Chronic Disease; Dyslipidemias; Female; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Lipid Metabolism; Lipids; Lipoproteins; Male; Methotrexate; Risk Factors | 2010 |
Methylxanthines and inflammatory cells.
Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theophylline | 2011 |
Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease.
Topics: Antirheumatic Agents; Arthritis; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Psoriasis; Risk Assessment | 2011 |
[Rheumatoid arthritis: a cardiovascular disease?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Risk Factors; Stroke; Tumor Necrosis Factor-alpha | 2012 |
Psoriasis and cardiovascular disorders.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Cardiotonic Agents; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus; Humans; Inflammation; Interleukin-12 Subunit p40; Metabolic Syndrome; Methotrexate; Obesity; Psoriasis; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Smoking; Tumor Necrosis Factor-alpha; Ustekinumab | 2012 |
Cardiovascular risk in rheumatoid arthritis: pathogenesis, diagnosis, and management.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Autoimmune Diseases; Cardiovascular Diseases; Carotid Arteries; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Methotrexate; Pulse Wave Analysis; Regional Blood Flow; Risk Factors; Stem Cells; Tunica Intima; Tunica Media; Vascular Calcification; Vascular Stiffness; Vasodilation | 2012 |
Sarcoid arthritis: a review of clinical features, pathology and therapy.
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chronic Disease; Environment; Genetic Predisposition to Disease; Granuloma; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Sarcoidosis; Tumor Necrosis Factor-alpha | 2003 |
Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis.
Topics: Azathioprine; Drug Antagonism; Drug Resistance; Drug Therapy, Combination; Humans; Immunologic Factors; Immunosuppressive Agents; Inflammation; Interferon-beta; Methotrexate; Mitoxantrone; Multiple Sclerosis | 2004 |
Potential mechanisms for chemotherapy-induced impairments in cognitive function.
Topics: Anemia; Animals; Antineoplastic Agents; Attention; Blood-Brain Barrier; Cognition Disorders; Cyclophosphamide; Doxorubicin; Encephalitis; Fluorouracil; Humans; Inflammation; Language; Learning; Memory; Menopause; Methotrexate; Neoplasms; Oncology Nursing; Paclitaxel; Psychomotor Performance; Spatial Behavior | 2005 |
A novel approach to the development of anti-inflammatory agents: adenosine release at inflamed sites.
Topics: Adenosine; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; Sulfasalazine | 1995 |
The pharmacology of antiinflammatory agents: a new paradigm.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Endothelium; Humans; Inflammation; Methotrexate | 1993 |
Methotrexate use in miscellaneous inflammatory diseases.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Connective Tissue Diseases; Humans; Inflammation; Lupus Erythematosus, Systemic; Methotrexate; Myositis; Sarcoidosis; Scleroderma, Systemic; Still's Disease, Adult-Onset | 1997 |
Molecular mechanism of methotrexate action in inflammation.
Topics: Adjuvants, Immunologic; Cells; Humans; Inflammation; Methotrexate; Methylation | 1992 |
Mechanisms of action of methotrexate.
Topics: Arthritis, Rheumatoid; Endothelium; Fibroblasts; Folic Acid; Humans; Immunosuppression Therapy; Inflammation; Methotrexate | 1991 |
Pharmacology and pathophysiology of inflammation.
Topics: Antibody Formation; Antigen-Antibody Reactions; Antilymphocyte Serum; Colchicine; Humans; Hydrocortisone; Hypersensitivity, Delayed; Immunity, Cellular; Immunoglobulin A; Immunoglobulin D; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppression Therapy; Immunosuppressive Agents; Inflammation; Lymphocytes; Lysosomes; Methotrexate; Microbial Collagenase; Nitrogen Mustard Compounds; Phagocytosis; Recurrence; Transplantation Immunology | 1971 |
20 trial(s) available for methotrexate and Innate Inflammatory Response
| Article | Year |
|---|---|
Methotrexate effects on adenosine receptor expression in peripheral monocytes of persons with type 2 diabetes and cardiovascular disease.
Topics: Adenosine; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Gene Expression; Humans; Inflammation; Leukocytes, Mononuclear; Methotrexate; Monocytes; Myocardial Infarction; Receptors, Purinergic P1 | 2022 |
Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.
Topics: Adult; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Cost of Illness; Double-Blind Method; Humans; Inflammation; Methotrexate; Treatment Outcome | 2022 |
Investigation on the Inhibitory Effect of Methotrexate on Rheumatoid Synovitis via the TLR4-NF-
Topics: Animals; Arthritis, Rheumatoid; Inflammation; Methotrexate; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Synovitis; Toll-Like Receptor 4; Water | 2022 |
Efficacy and safety of adalimumab for inflammatory flare prevention in paediatric non-infectious anterior uveitis with peripheral retinal vascular leakage: a study protocol for a single-centre, randomised controlled trial.
Topics: Adalimumab; Adolescent; Child; Child, Preschool; Humans; Inflammation; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome; Uveitis; Uveitis, Anterior | 2022 |
Baseline Objective Inflammation by Magnetic Resonance Imaging as a Predictor of Therapeutic Benefit in Early Rheumatoid Arthritis With Poor Prognosis.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Inflammation; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prognosis; Treatment Outcome | 2020 |
Pulmonary Adverse Events in Patients Receiving Low-Dose Methotrexate in the Randomized, Double-Blind, Placebo-Controlled Cardiovascular Inflammation Reduction Trial.
Topics: Adult; Age Factors; Cardiovascular Diseases; Double-Blind Method; Female; Humans; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Pneumonia; Risk Factors; Sex Factors | 2020 |
Pretreatment resistin levels are associated with erosive disease in early rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs and infliximab.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Drug Therapy, Combination; Follow-Up Studies; Humans; Inflammation; Infliximab; Methotrexate; Resistin; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Safety and Impact of Low-dose Methotrexate on Endothelial Function and Inflammation in Individuals With Treated Human Immunodeficiency Virus: AIDS Clinical Trials Group Study A5314.
Topics: Anti-Inflammatory Agents; Antiretroviral Therapy, Highly Active; Atherosclerosis; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium; Female; HIV Infections; HIV-1; Humans; Inflammation; Male; Methotrexate; Middle Aged | 2019 |
The relationship between disease activity and depressive symptoms severity and optimism--results from the IMPROVED study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude; Depression; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prednisone; Regression Analysis; Remission Induction; Severity of Illness Index; Surveys and Questionnaires | 2013 |
Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis.
Topics: Algorithms; Anti-Inflammatory Agents; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Inflammation; Metabolic Syndrome; Methotrexate; Myocardial Infarction; Research Design | 2013 |
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis.
Topics: Administration, Intravenous; Adolescent; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Antirheumatic Agents; Arthritis, Rheumatoid; Broadly Neutralizing Antibodies; Cytokine TWEAK; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Inflammation; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; TWEAK Receptor; Young Adult | 2013 |
Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Inflammation; Infliximab; Male; Methotrexate; Middle Aged; Models, Biological; Prednisone | 2014 |
Optimizing therapy in inflammatory arthritis: prediction of relapse after tapering or stopping treatment for rheumatoid arthritis patients achieving clinical and radiological remission.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biological Products; Disease Progression; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Proportional Hazards Models; Prospective Studies; Recurrence; Remission Induction; Rheumatology; ROC Curve; Synovitis; Treatment Outcome; Ultrasonography | 2016 |
Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy.
Topics: Adalimumab; Antigens, CD; Arthritis, Rheumatoid; Biomarkers; CD83 Antigen; Dendritic Cells; Female; Humans; Immunoglobulins; Immunotherapy; Inflammation; Male; Membrane Glycoproteins; Methotrexate; Microscopy, Confocal; Middle Aged; Synovial Fluid; Synovial Membrane; Tumor Necrosis Factor-alpha | 2017 |
Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis.
Topics: Adiponectin; Adult; Aged; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Atorvastatin; Drug Therapy, Combination; Endothelium, Vascular; Female; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Methotrexate; Middle Aged; Prednisone; Pyrroles; Regional Blood Flow; Resistin; Risk Factors; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2011 |
Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Disease Progression; Drug Therapy, Combination; Humans; Immunologic Factors; Inflammation; Interleukin-6; Joints; Methotrexate; Middle Aged; Treatment Outcome | 2012 |
Correlation of cerebrospinal fluid beta-glucuronidase activity with plasma methotrexate concentrations in leukemic children receiving high-dose methotrexate.
Topics: Biomarkers; Child; Child, Preschool; Clinical Enzyme Tests; Female; Glucuronidase; Humans; Infant; Inflammation; Linear Models; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
A randomized dose-response and pharmacokinetic study of methotrexate for refractory inflammatory Crohn's disease and ulcerative colitis.
Topics: Adult; Aged; Antirheumatic Agents; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Single-Blind Method; Time Factors; Treatment Outcome | 1999 |
Inflammation and damage in an individual joint predict further damage in that joint in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Inflammation; Joints; Methotrexate; Middle Aged; Predictive Value of Tests; Prednisolone; Prognosis; Sulfasalazine | 2001 |
ProMACE-cytaBOM versus MACOP-B in intermediate and high grade NHL. Preliminary results of a prospective randomized trial.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Hematopoiesis; Humans; Inflammation; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mucous Membrane; Prednisolone; Prednisone; Prognosis; Prospective Studies; Survival Analysis; Vincristine | 1991 |
258 other study(ies) available for methotrexate and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Three-component synthesis of chromeno β-lactam hybrids for inflammation and cancer screening.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Benzopyrans; beta-Lactams; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inflammation; Mice; Molecular Structure; Neoplasms; RAW 264.7 Cells; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Inflammation; Ligation; Lung; Male; Methotrexate; Punctures; Rats; Rats, Sprague-Dawley; Sepsis | 2021 |
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12 | 2023 |
Assessment of the cardioprotective effect of liraglutide on methotrexate induced cardiac dysfunction through suppression of inflammation and enhancement of angiogenesis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Cardiotonic Agents; Cardiotoxicity; Down-Regulation; Hypoglycemic Agents; Inflammation; Liraglutide; Male; Methotrexate; Neovascularization, Physiologic; Rats; Up-Regulation; Vascular Endothelial Growth Factor A | 2021 |
Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Methotrexate; Nebivolol; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats | 2022 |
Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Flavonoids; Inflammation; Liver; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2022 |
Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Disease Models, Animal; Humans; Hydroxyethylrutoside; Inflammation; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents | 2022 |
The inhibitory effect of tocilizumab on systemic bone loss and tendon inflammation in a juvenile Collagen-Induced arthritis rat model.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Juvenile; Cytokines; Inflammation; Interleukin-23; Interleukin-6; Male; Methotrexate; Rats; Tendons; Tumor Necrosis Factor-alpha; X-Ray Microtomography | 2022 |
Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-κB/NLRP3 pathway in Methotrexate-induced enteritis.
Topics: Animals; Antioxidants; Bridged-Ring Compounds; Enteritis; Inflammation; Male; Methotrexate; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2022 |
Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell-Free Nucleic Acids; DNA; Inflammation; Matrix Metalloproteinase 2; Methotrexate; Rats | 2022 |
Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Collagen; Humans; Inflammation; Macrophages; Methotrexate; Mice; Neuropilin-2; Semaphorins; Synovial Membrane | 2022 |
Impacts of Low-Dose Total Glycosides of Tripterygium wilfordii plus Methotrexate on Immunological Function and Inflammation Level in Patients with Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Glycosides; Humans; Inflammation; Methotrexate; Treatment Outcome; Tripterygium | 2022 |
The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats.
Topics: Activating Transcription Factor 6; Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Catalase; Endoplasmic Reticulum Chaperone BiP; Flavones; Glutathione Peroxidase; Inflammation; Male; Methotrexate; Mitogen-Activated Protein Kinase 14; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Testis; Tumor Necrosis Factor-alpha | 2022 |
Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Inflammation; Methotrexate; Pharmacogenetics | 2022 |
Uveitis and nail psoriasis in a patient without articular involvement: a case report.
Topics: Adalimumab; Glaucoma, Open-Angle; Humans; Inflammation; Male; Methotrexate; Psoriasis; Uveitis; Uveitis, Anterior | 2022 |
Endothelial dysfunction in psoriatic arthritis patients: correlations between insulin resistance and disease activity.
Topics: Arthritis, Psoriatic; Atherosclerosis; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Humans; Inflammation; Insulin Resistance; Methotrexate; Tumor Necrosis Factor-alpha | 2022 |
Porous Silicon-Based Nanomedicine for Simultaneous Management of Joint Inflammation and Bone Erosion in Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Drug Carriers; Inflammation; Methotrexate; Mice; Nanomedicine; Porosity; Silicon | 2022 |
Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Catalase; Cell Death; Chemical and Drug Induced Liver Injury; Glutathione; Inflammation; Interleukin-6; Liver; Malondialdehyde; Methotrexate; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Transaminases; Tumor Necrosis Factor-alpha | 2022 |
Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Catalase; Drug Therapy, Combination; Inflammation; Interleukin-17; Matrix Metalloproteinase 9; Methotrexate; Oxidative Stress; Rats; RNA, Messenger | 2022 |
Red Cell Distribution Width and Absolute Lymphocyte Count Associate With Biomarkers of Inflammation and Subsequent Mortality in Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Erythrocyte Indices; Humans; Inflammation; Lymphocyte Count; Methotrexate; Retrospective Studies | 2023 |
COVID-19 vaccination and recurrent anterior uveitis.
Topics: Acute Disease; Adult; COVID-19; COVID-19 Vaccines; Female; Humans; Inflammation; Methotrexate; SARS-CoV-2; Uveitis, Anterior; Vaccination | 2022 |
Methotrexate conjugated gold nanoparticles improve rheumatoid vascular dysfunction in rat adjuvant-induced arthritis: gold revival.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Gold; Inflammation; Metal Nanoparticles; Methotrexate; Rats | 2023 |
Inflammation specific environment activated methotrexate-loaded nanomedicine to treat rheumatoid arthritis by immune environment reconstruction.
Topics: Arthritis, Rheumatoid; Cytokines; Humans; Inflammation; Methotrexate; Nanomedicine | 2023 |
Cochlear Implantation in a Patient with Granulomatosis with Polyangiitis.
Topics: Aged; Cochlear Implantation; Female; Granulomatosis with Polyangiitis; Hearing Loss, Sensorineural; Humans; Inflammation; Methotrexate | 2022 |
Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model.
Topics: Animals; Antiviral Agents; Computational Biology; COVID-19; Cricetinae; Inflammation; Methotrexate; SARS-CoV-2 | 2022 |
Peri-osteosarcoma adipose computed tomography attenuation and volume for predicting chemotherapy response in pediatric patients.
Topics: Bone Neoplasms; Child; Humans; Inflammation; Methotrexate; Osteosarcoma; Retrospective Studies; Tomography | 2023 |
Protective role of naftidrofuryl against methotrexate-induced testicular damage via the amelioration of the p53/miRNA-29a/CDC42 apoptotic pathway, inflammation, and oxidative stress.
Topics: Animals; Antioxidants; Apoptosis; Inflammation; Male; Methotrexate; MicroRNAs; Nafronyl; Oxidative Stress; Rats; Tumor Suppressor Protein p53 | 2023 |
Five-year cardiovascular event risk in early rheumatoid arthritis patients who received treat-to-target management: a case-control study.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Case-Control Studies; Humans; Inflammation; Methotrexate; Risk Factors | 2023 |
The role of proteasome in muscle wasting of experimental arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Drug Therapy, Combination; Etanercept; Humans; Inflammation; Male; Methotrexate; Mice; Muscle, Skeletal; Proteasome Endopeptidase Complex; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2023 |
Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Inflammation; Methotrexate; Mice; Vaccines | 2023 |
Edaravone alleviates methotrexate-induced testicular injury in rats: Implications on inflammation, steroidogenesis, and Akt/p53 signaling.
Topics: Animals; Antioxidants; Edaravone; Humans; Inflammation; Male; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Testicular Diseases; Tumor Suppressor Protein p53 | 2023 |
Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity.
Topics: Animals; Dermatitis; Epithelial Cells; Immunity, Innate; Inflammation; Mammals; Methotrexate; Mice; Nod1 Signaling Adaptor Protein; Nod2 Signaling Adaptor Protein; Peptidoglycan | 2023 |
Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx.
Topics: Aconitum; Arthritis, Rheumatoid; Inflammation; Methotrexate; Polysaccharides | 2023 |
Methotrexate delivering microneedle patches for improved therapeutic efficacy in treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Delayed-Action Preparations; Guinea Pigs; Inflammation; Methotrexate | 2023 |
Immunosuppressive nanoparticles containing recombinant PD-L1 and methotrexate alleviate multi-organ inflammation.
Topics: Animals; Autoimmune Diseases; B7-H1 Antigen; Immunosuppressive Agents; Inflammation; Methotrexate; Mice; Mice, Knockout; Nanoparticles | 2023 |
Leveraging decagonal in-silico strategies for uncovering IL-6 inhibitors with precision.
Topics: Humans; Inflammation; Interleukin-6; Interleukin-6 Inhibitors; Methotrexate; Molecular Docking Simulation; Molecular Dynamics Simulation | 2023 |
Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Cross-Sectional Studies; Humans; Inflammation; Liver Diseases; Longitudinal Studies; Methotrexate; Mice; Obesity; Peptides, Cyclic | 2023 |
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Inflammation; Matrix Metalloproteinases; Methotrexate; Mice; Osteogenesis; Silver | 2023 |
[Pharmacological profiles and clinical efficacy of ozoralizumab (Nanozora
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Inflammation; Infliximab; Japan; Methotrexate; Mice; Receptors, Tumor Necrosis Factor; Syringes; Treatment Outcome; Tumor Necrosis Factor-alpha | 2023 |
N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Anxiety; Brain-Derived Neurotrophic Factor; Cholinergic Agents; Depression; Humans; Inflammation; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2024 |
Topics: Child; Dermatomyositis; Humans; Inflammation; Male; Methotrexate; Prednisolone; Skin | 2023 |
Alpha-linolenic acid protects against methotrexate-induced nephrotoxicity in mouse kidney cells.
Topics: alpha-Linolenic Acid; Animals; Antioxidants; Inflammation; Kidney; Methotrexate; Mice; Oxidative Stress | 2023 |
Steroid-sparing agents for the treatment of inflammation in complicated neurocysticercosis.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Neurocysticercosis | 2019 |
Antimetabolite Therapy for Uveitis: Methotrexate or Mycophenolate?
Topics: Adrenal Cortex Hormones; Antimetabolites; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Mycophenolic Acid; Uveitis | 2019 |
Regulation of CP-25 on P-glycoprotein in synoviocytes of rats with adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance; Glucosides; Inflammation; Intestine, Small; Joints; Male; Methotrexate; Monoterpenes; Rats, Sprague-Dawley; Rhodamine 123; Spleen; Synoviocytes; Tumor Necrosis Factor-alpha | 2019 |
[Rheumatoid arthritis in elderly people].
Topics: Age of Onset; Aged; Arthritis, Rheumatoid; Female; Glucocorticoids; Humans; Inflammation; Male; Methotrexate | 2019 |
Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Inflammation; Locomotion; Male; Methotrexate; Mice; Pain; Skin Temperature | 2019 |
Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.
Topics: Animals; Antioxidants; Coumaric Acids; Inflammation; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar; Up-Regulation | 2020 |
Granulomatous mural folliculitis in a dog treated with ciclosporin and methotrexate.
Topics: Alopecia; Animals; Cyclosporine; Disease Management; Dog Diseases; Dogs; Female; Folliculitis; Histological Techniques; Inflammation; Methotrexate; Skin; Skin Diseases | 2020 |
Dietary restriction increases protective gut bacteria to rescue lethal methotrexate-induced intestinal toxicity.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Caloric Restriction; Female; Gastrointestinal Microbiome; Humans; Inflammation; Intestinal Mucosa; Lacticaseibacillus rhamnosus; Methotrexate; Mice; Mice, Inbred C57BL; Probiotics; RNA, Ribosomal, 16S | 2020 |
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.
Topics: Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Catalase; Disease Models, Animal; Diterpenes; Edema; Freund's Adjuvant; Glutathione; Inflammation; Interleukin-1beta; Interleukin-6; Joints; Male; Methotrexate; Neutrophils; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Synovial Membrane; Tumor Necrosis Factor-alpha | 2020 |
The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes.
Topics: Animals; Chemical and Drug Induced Liver Injury; DNA-Binding Proteins; Drugs, Chinese Herbal; Immunosuppressive Agents; Inflammasomes; Inflammation; Liver; Methotrexate; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2020 |
From CANTOS to CIRT to COLCOT to Clinic: Will All Atherosclerosis Patients Soon Be Treated With Combination Lipid-Lowering and Inflammation-Inhibiting Agents?
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Atherosclerosis; C-Reactive Protein; Colchicine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Lipid Metabolism; Methotrexate; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction | 2020 |
Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling.
Topics: Animals; Antioxidants; Caffeic Acids; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Succinates; Up-Regulation | 2020 |
Silencing of immune activation with methotrexate in patients with COVID-19.
Topics: Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Pandemics; Pneumonia, Viral; SARS-CoV-2 | 2020 |
Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity.
Topics: Administration, Oral; Animals; Coumaric Acids; Dose-Response Relationship, Drug; Inflammation; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Methotrexate; Mice; Oxidative Stress; Protective Agents; Structure-Activity Relationship | 2020 |
Interleukin-6-Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Hypertension; Inflammation; Interleukin-6; Leukoencephalopathies; Methotrexate; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Methotrexate Pulmonary Toxicity: Deep Inspiration.
Topics: Double-Blind Method; Humans; Inflammation; Lung; Methotrexate | 2020 |
Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Catalase; Cytokines; Drug Carriers; Drug Compounding; Drug Liberation; Gels; Glutathione; Humans; Imiquimod; Inflammation; Lipids; Malondialdehyde; Methotrexate; Mice, Inbred BALB C; Nanostructures; Organ Size; Psoriasis; Superoxide Dismutase | 2020 |
Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Guaiacol; Inflammation; Kidney; Liver; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats | 2022 |
Enhanced Inflammasome Activity in Patients with Psoriasis Promotes Systemic Inflammation.
Topics: Adult; Aged; Aged, 80 and over; Animals; Case-Control Studies; Caspase 1; Female; Healthy Volunteers; Humans; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Male; Methotrexate; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Severity of Illness Index; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2021 |
[Anti-inflammatory therapy in cardiovascular disease; from hypothesis to future guideline?]
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Cardiovascular Diseases; Colchicine; Humans; Inflammation; Methotrexate; Myocardial Infarction; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Translational Research, Biomedical | 2020 |
The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Apoptosis; Chemical and Drug Induced Liver Injury; Inflammation; Kidney; Kidney Diseases; Luteolin; Male; Methotrexate; Oxidative Stress; Protective Agents; Rats | 2021 |
Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.
Topics: Arthralgia; Arthritis; Chikungunya Fever; Chikungunya virus; Cyclooxygenase 2; Cytokines; Dinoprostone; Endothelial Cells; Fibroblasts; Humans; Inflammation; Interleukin-1beta; Methotrexate; Prostaglandins; RNA, Messenger; Tumor Necrosis Factor-alpha | 2021 |
Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy.
Topics: Adrenergic alpha-2 Receptor Agonists; Autophagy; Cell Line; Cognitive Dysfunction; Dexmedetomidine; Ferritins; Hippocampus; Humans; Inflammation; Methotrexate; Neuroprotective Agents; Nuclear Receptor Coactivators | 2021 |
Effects of rhizome of Atractylodes koreana (Nakai) Kitam on intestinal flora and metabolites in rats with rheumatoid arthritis.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Atractylodes; Cytokines; DNA; Down-Regulation; Gastrointestinal Microbiome; Gene Expression Regulation; Inflammation; Intestines; Male; Methotrexate; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome; RNA, Ribosomal, 16S; Synovial Membrane | 2021 |
Serum miRNA Signature in Rheumatoid Arthritis and "At-Risk Individuals".
Topics: Adult; Aged; Aged, 80 and over; Arthralgia; Arthritis, Rheumatoid; Biomarkers; Circulating MicroRNA; Computational Biology; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; ROC Curve | 2021 |
[Rheumatic diseases, inflammation and cardiovascular risk].
Topics: Antirheumatic Agents; Cardiovascular Diseases; Humans; Inflammation; Methotrexate; Rheumatic Diseases; Risk Factors; Tumor Necrosis Factor-alpha | 2021 |
Resolution of vascular inflammation in patients with new-onset giant cell arteritis: data from the RIGA study.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Female; Giant Cell Arteritis; Glucocorticoids; Humans; Inflammation; Male; Methotrexate; Middle Aged; Positron Emission Tomography Computed Tomography; Prednisolone; Treatment Outcome | 2021 |
Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Down-Regulation; Glycyrrhiza; Humans; Inflammation; Isoflavones; Liver; Methotrexate; Mice; NF-kappa B; Oxidative Stress; Phenols; Protective Agents; Tumor Necrosis Factor-alpha | 2021 |
Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis.
Topics: Adult; Arthritis, Rheumatoid; Chemokines; Cluster Analysis; Cytokines; Humans; Inflammation; Lymphocytes; Methotrexate; Middle Aged; Spondylarthritis | 2021 |
Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-Tumor Activity.
Topics: Allyl Compounds; Animals; Apoptosis; Caco-2 Cells; Disulfides; Inflammation; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2022 |
Berberine and/or zinc protect against methotrexate-induced intestinal damage: Role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways.
Topics: Animals; Berberine; Forkhead Box Protein O3; Glycogen Synthase Kinase 3 beta; Inflammation; Intestines; Janus Kinase 1; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Sirtuin 1; STAT3 Transcription Factor; Zinc | 2021 |
Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats.
Topics: Acetylcysteine; Animals; Benzhydryl Compounds; Glucosides; Hesperidin; Inflammation; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats.
Topics: Aminopterin; Animals; Fibrosis; Folate Receptor 2; Folic Acid; Glomerulonephritis; Inflammation; Macrophages; Methotrexate; Rats | 2021 |
Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis.
Topics: Acetophenones; Animals; Antioxidants; Biomarkers; Inflammation; Interleukin-6; Kelch-Like ECH-Associated Protein 1; Male; Methotrexate; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; Peroxidase; PPAR gamma; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Testis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2021 |
Therapeutic effect of quercetin in collagen-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chemokine CCL2; Collagen; Disease Models, Animal; Inflammation; Interleukin-17; Interleukin-1beta; Joints; Methotrexate; Mice; Mice, Inbred C57BL; Protective Agents; Quercetin; Tumor Necrosis Factor-alpha | 2017 |
Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.
Topics: Animals; Apoptosis; Body Weight; Down-Regulation; Glycyrrhetinic Acid; Inflammation; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar | 2017 |
A novel JAK inhibitor JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents.
Topics: Animals; Cyclosporine; Cytokines; Dermatitis, Atopic; Female; Haptens; Humans; Immunoglobulin E; Inflammation; Interleukin-23; Interleukin-23 Subunit p19; Janus Kinase Inhibitors; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Rats; Rats, Inbred BN; Skin; Thymic Stromal Lymphopoietin | 2018 |
Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Chlorogenic Acid; Down-Regulation; Glutathione; Inflammation; Lipid Peroxidation; Liver; Male; Methotrexate; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar | 2017 |
Protective effects of phloridzin against methotrexate-induced liver toxicity in rats.
Topics: Acetylcysteine; Animals; Biomarkers; Caspase 3; Inflammation; Liver; Male; Methotrexate; Oxidative Stress; Phlorhizin; Protective Agents; Rats; Survival Analysis | 2017 |
Attenuation of Myeloid-Specific TGFβ Signaling Induces Inflammatory Cerebrovascular Disease and Stroke.
Topics: Animals; Cell Line; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Penetrance; Signal Transduction; Stroke; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2017 |
Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect.
Topics: Aging; Animals; Biomarkers; Body Weight; Estradiol; Follicle Stimulating Hormone; Grape Seed Extract; Inflammation; Letrozole; Male; Methotrexate; Nitriles; Organ Size; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Seminiferous Tubules; Sperm Count; Sperm Motility; Spermatogenesis; Testosterone; Triazoles | 2018 |
Radiolabeled methotrexate as a diagnostic agent of inflammatory target sites: A proof-of-concept study.
Topics: Animals; Drug Stability; Durapatite; Humans; Inflammation; Isotope Labeling; Methotrexate; Mice; Molecular Imaging; Organotechnetium Compounds; Protein Binding; Tissue Distribution | 2018 |
Bone-targeted methotrexate-alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo.
Topics: Alendronate; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Collagen; Cytokines; Drug Therapy, Combination; Female; Inflammation; Male; Methotrexate; Mice; Mice, Inbred C57BL; Muramidase; Osteoclasts; Osteogenesis; Rats; Rats, Wistar | 2018 |
Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Methotrexate; Mice; Signal Transduction; Synovial Fluid; Toll-Like Receptors; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha | 2018 |
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Male; Methotrexate; Mice; Monocytes; Purines; Synovial Fluid | 2018 |
Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Heme Oxygenase-1; Hepatic Stellate Cells; Inflammation; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Signal Transduction; Thioctic Acid | 2018 |
Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Inflammation; Methotrexate; Phenotype; Piperidines; Pyrimidines; Pyrroles; Receptors, Interleukin-6; Signal Transduction | 2018 |
NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Cyclooxygenase 2; Guanidines; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Inflammation; Inflammation Mediators; Intestine, Small; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; NF-kappa B; Nitric Oxide Synthase Type II; Phospholipases A2; Rats, Wistar; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; Bone and Bones; Cartilage; Inflammation; Liver; Male; Methotrexate; Ranibizumab; Rats; Receptors, Interleukin-6; Spleen; Vascular Endothelial Growth Factor A | 2018 |
Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS).
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Chromatography, Liquid; Cytokines; Inflammation; Male; Metabolomics; Methotrexate; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Losartan suppresses the inflammatory response in collagen-induced arthritis by inhibiting the MAPK and NF-κB pathways in B and T cells.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Collagen; Cytokines; Female; Humans; Inflammation; Losartan; Male; Methotrexate; Middle Aged; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes | 2019 |
Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Autophagosomes; Autophagy; Biological Therapy; Etanercept; Female; Humans; Inflammation; Male; Methotrexate; Microtubule-Associated Proteins; Middle Aged; Pilot Projects; Prospective Studies; Receptors, Interleukin-6; Sequestosome-1 Protein; Tumor Necrosis Factor-alpha | 2018 |
Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features.
Topics: Cell Differentiation; Cell Movement; Cell Proliferation; Dermis; Epithelium; Female; Humans; Immunocompetence; Inflammation; Inflammation Mediators; Keratinocytes; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Models, Biological; Phenotype; Psoriasis; Signal Transduction; Skin; T-Lymphocytes | 2019 |
Development of a methotrexate educational guide/information/monitoring booklet for inflammatory arthritis.
Topics: Antirheumatic Agents; Arthritis; Humans; Inflammation; Methotrexate; Patient Education as Topic; Pilot Projects | 2019 |
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Biomarkers; Carotenoids; Chemical and Drug Induced Liver Injury, Chronic; Dose-Response Relationship, Drug; Inflammation; Male; Methotrexate; Oxidative Stress; Rats, Wistar | 2019 |
Comparison Between Methotrexate and Mycophenolate Mofetil Monotherapy for the Control of Noninfectious Ocular Inflammatory Diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Infant; Inflammation; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Prednisone; Retrospective Studies; Scleritis; Uveitis; Visual Acuity | 2019 |
Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biomarkers; Cytokines; Female; Folic Acid; Gene Expression Regulation; Humans; Inflammation; Male; Methotrexate; Randomized Controlled Trials as Topic; Thrombosis | 2013 |
Dysregulation in myelination mediated by persistent neuroinflammation: possible mechanisms in chemotherapy-related cognitive impairment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition Disorders; Corpus Callosum; Cyclophosphamide; Cytokines; Female; Fluorouracil; Inflammation; Methotrexate; Nerve Fibers, Myelinated; Random Allocation; Rats; Rats, Sprague-Dawley; Recognition, Psychology | 2014 |
Methotrexate treatment causes early onset of disease in a mouse model of Ross River virus-induced inflammatory disease through increased monocyte production.
Topics: Alphavirus Infections; Animals; Antirheumatic Agents; Arthritis; CD11b Antigen; Disease Models, Animal; Inflammation; Inflammation Mediators; Methotrexate; Mice; Monocytes; Muscle, Skeletal; Ross River virus | 2013 |
Impact of 24-month treatment with etanercept, adalimumab, or methotrexate on metabolic syndrome components in a cohort of 210 psoriatic arthritis patients.
Topics: Adalimumab; Adipocytes; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Apoptosis; Arthritis, Psoriatic; Biological Products; Cohort Studies; Comorbidity; Etanercept; Female; Humans; Immunoglobulin G; Inflammation; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2014 |
Disruption of ZO-1/claudin-4 interaction in relation to inflammatory responses in methotrexate-induced intestinal mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Chemokines; Claudin-4; Cytokines; Gene Expression Regulation; Inflammation; Inflammation Mediators; Intestine, Small; Male; Methotrexate; Mucositis; Occludin; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tight Junctions; Zonula Occludens-1 Protein | 2013 |
Anti-inflammatory and antioxidant effects of an ethanolic extract of the aerial parts of Hilleria latifolia (Lam.) H. Walt. (Phytolaccaceae).
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Biphenyl Compounds; Carrageenan; Chickens; Chronic Disease; Dexamethasone; Dose-Response Relationship, Drug; Edema; Free Radicals; Ghana; Inflammation; Iron Compounds; Lipid Peroxidation; Male; Methotrexate; Phytolaccaceae; Phytotherapy; Picrates; Plant Components, Aerial; Plant Extracts | 2012 |
Alterations in both the activatory and inhibitory potential of peripheral blood CD4+ T cells in rheumatoid arthritis patients correlate with disease progression.
Topics: Antigens, CD; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Proliferation; CTLA-4 Antigen; Disease Progression; Female; Humans; Inflammation; Lymphocyte Activation; Male; Methotrexate; Middle Aged; Tumor Necrosis Factor-alpha | 2014 |
Infliximab dose reduction sustains the clinical treatment effect in active HLAB27 positive ankylosing spondylitis: a two-year pilot study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; HLA-B27 Antigen; Humans; Inflammation; Infliximab; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Pilot Projects; Prospective Studies; Quality of Life; Sacroiliac Joint; Spondylitis, Ankylosing; Time Factors | 2013 |
A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chromones; Collagen; I-kappa B Kinase; Inflammation; Interleukin-17; Isoxazoles; Leflunomide; Male; Methotrexate; Mice; Mice, Inbred DBA; Phosphorylation; Signal Transduction; Sulfonamides; Synovial Membrane; TNF Receptor-Associated Factor 5 | 2013 |
Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells.
Topics: Antimetabolites, Antineoplastic; Atherosclerosis; Bromodeoxyuridine; Cell Line; Cell Proliferation; Cell Survival; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Gene Expression; Humans; Inflammation; Methotrexate; Phenotype | 2014 |
The impact of hepatitis screening on diagnosis and treatment in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis C Antibodies; Humans; Immunosuppressive Agents; Inflammation; Male; Mass Screening; Methotrexate; Middle Aged; Prevalence; Young Adult | 2014 |
[Methotrexate as inducer of proinflammatory cytokines by epithelial cells].
Topics: Antimetabolites, Antineoplastic; Carcinoma; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Laryngeal Neoplasms; Methotrexate; Stomatitis; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase | 2014 |
Skin-penetrating methotrexate alleviates imiquimod-induced psoriasiform dermatitis via decreasing IL-17-producing gamma delta T cells.
Topics: Aminoquinolines; Animals; CD11c Antigen; CD4-Positive T-Lymphocytes; Cytokines; Dermatitis; DNA, Complementary; Female; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Methotrexate; Mice; Mice, Inbred BALB C; Peptides; Permeability; Psoriasis; Skin | 2014 |
N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Freund's Adjuvant; Inflammation; Male; Methotrexate; NF-kappa B; Rats; Rats, Inbred Lew; Serotonin | 2014 |
Markers of inflammation and oxidative stress studied in adjuvant-induced arthritis in the rat on systemic and local level affected by pinosylvin and methotrexate and their combination.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; C-Reactive Protein; Chemokine CCL2; Drug Synergism; Drug Therapy, Combination; F2-Isoprostanes; gamma-Glutamyltransferase; Heme Oxygenase-1; Hindlimb; Inflammation; Lipoxygenase; Liver; Lung; Male; Methotrexate; NF-kappa B; Oxidative Stress; Rats; Rats, Inbred Lew; Spleen; Stilbenes; Thiobarbituric Acid Reactive Substances | 2015 |
Effect of methotrexate upon antigen-induced arthritis of the rabbit temporomandibular joint.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Female; Inflammation; Injections, Intra-Articular; Methotrexate; Ovalbumin; Rabbits; Random Allocation; Temporomandibular Joint; Temporomandibular Joint Disorders | 2015 |
Ultrasound composite scores for the assessment of inflammatory and structural pathologies in Psoriatic Arthritis (PsASon-Score).
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Bone and Bones; Feasibility Studies; Female; Follow-Up Studies; Humans; Inflammation; Isoxazoles; Joints; Leflunomide; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Reproducibility of Results; Severity of Illness Index; Sulfasalazine; Surveys and Questionnaires; Synovial Membrane; Tendons; Time Factors; Ultrasonography, Doppler | 2014 |
Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; B-Lymphocytes; Cells, Cultured; Collagen; Cytokines; Disease Models, Animal; Humans; In Vitro Techniques; Inflammation; Interferon-gamma; Interleukin-2; Janus Kinases; Mast Cells; Methotrexate; Mice; Mice, Inbred DBA; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes | 2015 |
Brief Report: Methotrexate Prevents Wear Particle-Induced Inflammatory Osteolysis in Mice Via Activation of Adenosine A2A Receptor.
Topics: Animals; Bone Marrow Cells; Humans; Inflammation; Male; Methotrexate; Mice; Mice, Inbred C57BL; Osteoclasts; Osteolysis; Polyethylenes; Receptor, Adenosine A2A; Skull | 2015 |
Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Antirheumatic Agents; Cyclic AMP Response Element-Binding Protein; Endothelium, Vascular; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethyl and Formyl Transferases; Inflammation; Methotrexate; Mice; Multienzyme Complexes; Nucleotide Deaminases; Phosphorylation; Rheumatoid Vasculitis; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate.
Topics: Aminopeptidases; Animals; Antirheumatic Agents; Arthritis, Experimental; Bee Venoms; CD13 Antigens; Cyanosis; Dipeptidyl Peptidase 4; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Leukocytes, Mononuclear; Male; Methotrexate; Pain; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2015 |
Daily practice feasibility and effectiveness of treating long-standing rheumatoid arthritis to target with synthetic disease-modifying antirheumatic drugs: a prospective cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Feasibility Studies; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction; Severity of Illness Index; Sulfasalazine; Treatment Outcome | 2015 |
Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats.
Topics: Animals; Antioxidants; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Collagen; Cytokines; Inflammation; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Roots; Rats, Wistar; Withania | 2015 |
In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Diarrhea; Disease Models, Animal; Imidazoles; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mucositis; Neoplasms; Olmesartan Medoxomil; Rats, Wistar; Sucrose; Tetrazoles; Tumor Necrosis Factor-alpha; Weight Loss | 2015 |
Effect of infliximab on renal injury due to methotrexate in rat.
Topics: Adenosine Deaminase; Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carbonic Anhydrase II; Cytokines; Inflammation; Infliximab; Interleukin-1beta; Kidney; Male; Methotrexate; Nitric Oxide; Protective Agents; Rats; Rats, Wistar; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Anti inflammatory effect of thymoquinone in comparison with methotrexate on pristane induced arthritis in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Body Weight; Female; Foot Joints; Immunosuppressive Agents; Inflammation; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes | 2015 |
[Feared complications in patients treated for inflammatory disease in the era of biotherapeutic products].
Topics: Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Tumor Necrosis Factor-alpha | 2015 |
Comparison of the Therapeutic Effects of Thymoquinone and Methotrexate on Renal Injury in Pristane Induced Arthritis in Rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Creatinine; Female; Humans; Inflammation; Kidney; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes; Urea | 2015 |
MRI evidence of persistent joint inflammation and progressive joint damage despite clinical remission during treatment of early rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Edema; Etanercept; Female; Glucocorticoids; Hand Bones; Humans; Inflammation; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Methotrexate; Middle Aged; Prednisolone; Prognosis; Remission Induction; Severity of Illness Index; Synovitis; Tenosynovitis; Wrist Joint | 2016 |
Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model.
Topics: Animals; Arthritis, Rheumatoid; Chronic Disease; Disease Models, Animal; Drug Carriers; Humans; Inflammation; Interferon-gamma; Interleukin-17; Lipids; Methotrexate; Nanocapsules; Rats; Synovial Membrane; T-Lymphocytes | 2015 |
Unilateral uveitis masquerade syndrome caused by diffuse large B-cell lymphoma diagnosed using multiparametric flow cytometry of the aqueous humor.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Aqueous Humor; B-Lymphocytes; Biomarkers; Cyclophosphamide; Diagnosis, Differential; Doxorubicin; Flow Cytometry; Gene Expression; Humans; Inflammation; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Paracentesis; Prednisone; Treatment Outcome; Uvea; Uveitis; Vincristine | 2017 |
Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects.
Topics: Acids; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Arachidonate 15-Lipoxygenase; Cytokines; Inflammation; Intestinal Diseases; Intestines; Methotrexate; Oxidative Stress; Phytotherapy; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Rats, Wistar; Rutin | 2016 |
Long-Term Effects of (-)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats.
Topics: Animals; Arthritis; Biomarkers; Catechin; Chronic Disease; Female; Inflammation; Methotrexate; Orosomucoid; Peroxidase; Rats; Terpenes | 2016 |
[Polymyalgia rheumatic--what's new?].
Topics: Antirheumatic Agents; Humans; Inflammation; Methotrexate; Middle Aged; Polymyalgia Rheumatica | 2016 |
High Efficacy of Methotrexate in Patients with Recurrent Idiopathic Acute Anterior Uveitis: a Prospective Study.
Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Female; Follow-Up Studies; HLA-B27 Antigen; Humans; Immunosuppressive Agents; Immunotherapy; Inflammation; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Recurrence; Time Factors; Uveitis, Anterior | 2017 |
Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model.
Topics: Administration, Cutaneous; Animals; Arthritis, Experimental; Cell Survival; Cytokines; Disease Models, Animal; Female; Humans; Inflammation; Lipids; Methotrexate; Nanostructures; Rats; Rats, Wistar | 2016 |
The effect of low-dose methotrexate on autologous fat graft survival.
Topics: Animals; Fats; Graft Survival; Inflammation; Lipid Peroxidation; Male; Methotrexate; Rats; Rats, Wistar | 2016 |
Methotrexate Locally Released from Poly(e-Caprolactone) Implants: Inhibition of the Inflammatory Angiogenesis Response in a Murine Sponge Model and the Absence of Systemic Toxicity.
Topics: Acetylglucosaminidase; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Cell Proliferation; Collagen; Drug Delivery Systems; Drug Implants; Drug Liberation; Inflammation; Interleukin-6; Macrophages; Male; Methotrexate; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Neutrophil Infiltration; Peroxidase; Polyesters; Tissue Distribution; Tumor Necrosis Factor-alpha | 2015 |
Inflammation Caused by Nanosized Delivery Systems: Is There a Benefit?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyanoacrylates; Drug Delivery Systems; Enbucrilate; Gelatin; Glucocorticoids; Inflammation; Macrophages; Methotrexate; Mice; Nanoparticles; Particle Size | 2016 |
Effects of Methotrexate in a Rabbit Model of In-Stent Neoatherosclerosis: An Optical Coherence Tomography Study.
Topics: Animals; Atherosclerosis; Carotid Artery Diseases; Cytokines; Disease Models, Animal; Drug-Eluting Stents; Image Processing, Computer-Assisted; Immunohistochemistry; Inflammation; Male; Methotrexate; NF-kappa B; Rabbits; Reproducibility of Results; Stents; Tomography, Optical Coherence | 2016 |
FDG-Avid Intrathecal Inflammation Following Administration of Intrathecal Methotrexate.
Topics: Antimetabolites, Antineoplastic; Humans; Inflammation; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Positron Emission Tomography Computed Tomography; Spinal Diseases | 2016 |
Aseptic inflammation of prosthetic knee in a patient affected by rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Female; Humans; Immunocompromised Host; Inflammation; Knee Joint; Methotrexate; Prosthesis-Related Infections; Radionuclide Imaging; Synovitis; Treatment Outcome; Tumor Necrosis Factor-alpha | 2016 |
Juvenile dermatomyositis: a tertiary center experience.
Topics: Adrenal Cortex Hormones; Child; Dermatomyositis; Electromyography; Exanthema; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Muscle Weakness; Muscular Diseases; Myositis; Pediatrics; Remission Induction; Retrospective Studies; Rheumatology; Skin; Tertiary Care Centers; Treatment Outcome; Turkey | 2017 |
Diet to the Rescue: Cessation of Pharmacotherapy After Initiation of Exclusive Enteral Nutrition (EEN) Followed by Strict and Liberalized Specific Carbohydrate Diet (SCD) in Crohn's Disease.
Topics: Adolescent; Blood Sedimentation; Crohn Disease; Deprescriptions; Dietary Carbohydrates; Enteral Nutrition; Feces; Humans; Inflammation; Leukocyte L1 Antigen Complex; Male; Methotrexate; Prednisone | 2017 |
Evidence for inflammation in Fabry's disease? Headache and muscle involvement responding to corticosteroid and methotrexate treatment.
Topics: Adrenal Cortex Hormones; Adult; Diagnosis, Differential; Enzyme Replacement Therapy; Fabry Disease; Female; Headache; Humans; Inflammation; Methotrexate; Myalgia | 2017 |
Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Drug Therapy, Combination; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Serum Amyloid P-Component; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Methotrexate improves perivascular adipose tissue/endothelial dysfunction via activation of AMPK/eNOS pathway.
Topics: 3T3-L1 Cells; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Endothelium, Vascular; Enzyme Activation; Inflammation; Male; Methotrexate; Mice; Nitric Oxide Synthase Type III; Rats, Sprague-Dawley; Signal Transduction; Vasodilation | 2017 |
Cardiovascular inflammation is reduced with methotrexate in diabetes.
Topics: Animals; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Inflammation; Methotrexate; Mice; Mice, Transgenic | 2017 |
Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cytokines; Epithelium; Female; Fluorouracil; Gastrointestinal Tract; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Irinotecan; Methotrexate; NF-kappa B; Rats; Tumor Necrosis Factor-alpha | 2008 |
Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: a critical assessment of the evidence.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites; Azathioprine; Daclizumab; Databases, Factual; Humans; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Longitudinal Studies; Methotrexate; Mycophenolic Acid; Neoplasms; Risk Factors; Tumor Necrosis Factor-alpha; Uveitis | 2008 |
Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Azathioprine; Child; Female; Glucocorticoids; Humans; Inflammation; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Prednisone; Retrospective Studies; Scleritis; Uveitis | 2008 |
[Three patients with a fracture during methotrexate use, possibly due to methotrexate osteopathy].
Topics: Aged; Bone Diseases, Metabolic; Female; Fractures, Stress; Humans; Immunosuppressive Agents; Inflammation; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Osteoporosis; Remission, Spontaneous | 2008 |
The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.
Topics: Atherosclerosis; Cell Line; Chemokine CCL2; Cytokines; Disease Progression; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Inflammation; Methotrexate; Models, Biological; p38 Mitogen-Activated Protein Kinases; Transcription, Genetic; Up-Regulation | 2009 |
[Anti-TNFalpha therapy in systemic autoimmune and/or inflammatory diseases].
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Autoimmune Diseases; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Infliximab; Methotrexate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2009 |
Intravenous immune globulins to treat eosinophilic fasciitis: a case report.
Topics: Adult; Arm; Electromyography; Eosinophilia; Foot; Hand; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Inflammation; Joint Diseases; Male; Methotrexate; Muscle, Skeletal; Muscular Diseases; Myositis; Raynaud Disease | 2009 |
Methotrexate for ocular inflammatory diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Conjunctival Diseases; Female; Humans; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Pemphigoid, Benign Mucous Membrane; Retrospective Studies; Scleritis; Treatment Outcome; Uveitis; Visual Acuity | 2009 |
Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.
Topics: Animals; Antimetabolites, Antineoplastic; Blotting, Western; Dextrans; Fluorescein-5-isothiocyanate; Immunohistochemistry; Immunoprecipitation; Inflammation; Intestinal Mucosa; Intestine, Small; Luminescence; Male; Membrane Proteins; Methotrexate; Permeability; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions; Tyrosine; Zonula Occludens-1 Protein | 2010 |
Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.
Topics: Animals; Body Weight; Cathepsin D; Cathepsins; Chemokines, CXC; Eating; Gene Expression; Inflammation; Interleukin-1beta; Intestinal Mucosa; Leucine; Male; Methotrexate; Mucositis; Pepstatins; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2010 |
Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: a case-control study.
Topics: Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Biomarkers; Biopsy; Case-Control Studies; Elasticity Imaging Techniques; Female; Humans; Inflammation; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Prospective Studies; Risk Factors | 2010 |
Combined methotrexate and coenzyme Q₁₀ therapy in adjuvant-induced arthritis evaluated using parameters of inflammation and oxidative stress.
Topics: Animals; Arthritis, Experimental; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-1alpha; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Rats; Ubiquinone | 2010 |
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Female; Foot; Indomethacin; Inflammation; Methotrexate; Mice; Mice, Inbred DBA; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Splenomegaly; X-Ray Microtomography | 2011 |
[Current "off label use" of methotrexate for chronic inflammatory rheumatic diseases].
Topics: Antirheumatic Agents; Chronic Disease; Germany; Humans; Inflammation; Methotrexate; Off-Label Use; Rheumatic Diseases | 2011 |
Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immune Tolerance; Inflammation; Male; Methotrexate; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Absent "Window of Opportunity" in smokers with short disease duration. Data from BARFOT, a multicenter study of early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Health Status; Humans; Inflammation; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Rheumatoid Factor; Severity of Illness Index; Smoking; Sulfasalazine; Surveys and Questionnaires; Treatment Outcome | 2011 |
Evaluation of lasting high levels of CRP among the patients with metabolic syndrome.
Topics: Adipose Tissue; Biomarkers; Body Mass Index; C-Reactive Protein; Female; Humans; Inflammation; Insulin Resistance; Intra-Abdominal Fat; Male; Metabolic Syndrome; Methotrexate | 2012 |
Treatment with methotrexate inhibits atherogenesis in cholesterol-fed rabbits.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Atherosclerosis; Cell Movement; Cell Proliferation; Cholesterol, Dietary; Dose-Response Relationship, Drug; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Macrophages; Male; Methotrexate; Myocytes, Smooth Muscle; Rabbits; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Tumor necrosis factor blockade differentially affects innate inflammatory and Th17 cytokines in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Etanercept; Female; Humans; Immunity, Innate; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Th17 Cells; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Investigation of nano lipid vesicles of methotrexate for anti-rheumatoid activity.
Topics: Analysis of Variance; Animals; Antirheumatic Agents; Arthritis, Experimental; Calorimetry, Differential Scanning; Chitosan; Drug Stability; Inflammation; Liposomes; Male; Methotrexate; Nanoparticles; Particle Size; Rats; Rats, Wistar | 2012 |
Effects of methotrexate on inflammatory alterations induced by obesity: an in vivo and in vitro study.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Adiposity; Animals; Body Weight; Coculture Techniques; Cytokines; Diet, High-Fat; Epididymis; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipolysis; Macrophages; Male; Methotrexate; Mice; Nitric Oxide Synthase Type II; Obesity; Phosphorylation | 2012 |
Psoriasis as initiator or amplifier of the systemic inflammatory march: impact on development of severe vascular events and implications for treatment strategy.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Immunosuppressive Agents; Inflammation; Male; Metabolic Diseases; Methotrexate; Middle Aged; Psoriasis; Severity of Illness Index | 2013 |
Rituximab dissociates the tight link between disease activity and joint damage in rheumatoid arthritis patients.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Humans; Inflammation; Joints; Methotrexate; Radiography; Retrospective Studies; Rituximab | 2013 |
Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.
Topics: Adenosine; ARNTL Transcription Factors; Arthritis, Rheumatoid; Cell Line; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Cryptochromes; Fatigue; Humans; Inflammation; Interleukin-1; Interleukin-10; Methotrexate; Monocytes; Period Circadian Proteins; Phenethylamines; Receptor, Adenosine A2A; RNA, Messenger; Tumor Necrosis Factor-alpha | 2013 |
Cardiovascular disease. Massive trials to test inflammation hypothesis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; C-Reactive Protein; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Inflammation; Interleukin-1beta; Methotrexate | 2012 |
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model.
Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Methotrexate; Plant Extracts; Plant Leaves; Prednisolone; Rats; Rats, Wistar; Solvents | 2013 |
Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Clarithromycin; Diarrhea; Gastrointestinal Transit; Glutathione; Ileum; Inflammation; Intestinal Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Probiotics; Rats; Rats, Sprague-Dawley; Saccharomyces | 2013 |
Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: a case report.
Topics: Abdominal Neoplasms; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Biopsy; Cisplatin; Diclofenac; Female; Fibroblasts; Humans; Inflammation; Methotrexate; Retroperitoneal Neoplasms; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Longitudinal Studies; Lymphocytes; Male; Methotrexate; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Rituximab; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy.
Topics: Arthralgia; Carrier Proteins; Central Nervous System Diseases; Child; Chronic Disease; Cytokines; DNA Mutational Analysis; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammation; Male; Meningitis; Methotrexate; Mutation, Missense; NLR Family, Pyrin Domain-Containing 3 Protein; Optic Nerve Diseases; Syndrome; Urticaria | 2004 |
Immunosuppressants, infection, and inflammation.
Topics: Arthralgia; Arthritis, Juvenile; Child, Preschool; Fever; Humans; Immunosuppressive Agents; Infections; Inflammation; Male; Methotrexate; Naproxen | 2004 |
Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthroscopy; Cytokines; Gene Expression; Humans; Immunohistochemistry; Inflammation; Knee; Metalloproteases; Methotrexate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane | 2004 |
The pseudopapilledema of neonatal-onset multisystem inflammatory disease.
Topics: Age of Onset; Autoimmune Diseases; Child; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammation; Intracranial Hypertension; Magnetic Resonance Imaging; Methotrexate; Nerve Fibers; Optic Disk; Papilledema; Photography; Prednisolone | 2004 |
Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Marrow Cells; CD28 Antigens; CD3 Complex; Cell Proliferation; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunosuppressive Agents; Inflammation; Isoxazoles; Leflunomide; Leukocytes; Leukocytes, Mononuclear; Lymphocyte Activation; Methotrexate; Mice; Neutrophils; Random Allocation; Rats; Rats, Inbred Lew; T-Lymphocytes; Tacrolimus; Time Factors | 2004 |
FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation.
Topics: Animals; Arthritis, Experimental; Body Weight; Female; Femur Head; Hyperalgesia; Immunosuppressive Agents; Inflammation; Methotrexate; Motor Activity; Muscle, Skeletal; Pain; Proteoglycans; Rats; Rats, Inbred Lew; Tacrolimus | 2005 |
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation.
Topics: Acute Disease; Adenosine; Air; Animals; Anti-Inflammatory Agents; Carrageenan; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Exudates and Transudates; Inbreeding; Inflammation; Injections, Subcutaneous; Methotrexate; Mice; Mice, Inbred Strains; Osmolar Concentration; Phenotype; Quantitative Trait Loci | 2005 |
Sclerosing encapsulating peritonitis and methotrexate.
Topics: Abortifacient Agents, Nonsteroidal; Adult; Antimetabolites, Antineoplastic; Female; Humans; Hydatidiform Mole; Inflammation; Laparotomy; Methotrexate; Peritonitis; Pregnancy; Sclerosis; Uterine Neoplasms | 2006 |
Copolymers of pharmaceutical grade lactic acid and sebacic acid: drug release behavior and biocompatibility.
Topics: Animals; Biocompatible Materials; Buffers; Chemistry, Pharmaceutical; Decanoic Acids; Dicarboxylic Acids; Drug Carriers; Drug Compounding; Female; Hydrogen-Ion Concentration; Inflammation; Injections, Subcutaneous; Kinetics; Lactic Acid; Methotrexate; Microspheres; Particle Size; Polymers; Rats; Rats, Sprague-Dawley; Solubility; Time Factors | 2006 |
Design of a new line in treatment of experimental rheumatoid arthritis by artesunate.
Topics: Animals; Artemisinins; Artesunate; Arthritis, Experimental; Autoantibodies; Cell Line, Tumor; Cell Survival; Collagen Type II; Collagenases; Edema; Foot Injuries; Hindlimb; Humans; Inflammation; Injections, Intradermal; Injections, Intraperitoneal; Male; Matrix Metalloproteinase Inhibitors; Methotrexate; Nitric Oxide; Radiography; Rats; Rats, Inbred Lew; Sesquiterpenes; Time Factors | 2006 |
Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Disability Evaluation; Disease Progression; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Inflammation; Joints; Methotrexate; Radiography; Receptors, Tumor Necrosis Factor; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Asthma; Autoimmune Diseases; Drug Synergism; Gene Expression Regulation; Humans; Immunosuppressive Agents; Inflammation; Jurkat Cells; Lipopolysaccharides; Lymphocytes; Methotrexate; Protein Isoforms; Receptors, Glucocorticoid; Theobromine; Vasodilator Agents | 2007 |
Severe gastrointestinal inflammation in adult dermatomyositis: characterization of a novel clinical association.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Cyclophosphamide; Dermatomyositis; Fatal Outcome; Female; Gastrointestinal Diseases; Humans; Hydroxychloroquine; Immunoglobulins, Intravenous; Immunosuppressive Agents; Inflammation; Methotrexate; Prednisolone | 2006 |
Tailoring biological treatment: anakinra treatment of posterior uveitis associated with the CINCA syndrome.
Topics: Anti-Inflammatory Agents; Child, Preschool; Etanercept; Follow-Up Studies; Humans; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Interleukin 1 Receptor Antagonist Protein; Joint Diseases; Male; Methotrexate; Methylprednisolone; Prednisolone; Receptors, Tumor Necrosis Factor; Syndrome; Uveitis, Posterior | 2007 |
The potential benefits of green tea in patients with uveitis.
Topics: Anti-Inflammatory Agents; Antioxidants; Catechin; Clinical Trials as Topic; Folic Acid; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Models, Biological; Models, Theoretical; Tea; Uveitis | 2007 |
Histopathological findings in the gastrointestinal tract of primate recipients of porcine renal xenografts following different immunosuppressive regimens.
Topics: Animals; Atrophy; CD55 Antigens; Cyclophosphamide; Female; Gastrointestinal Tract; Graft Rejection; Immunosuppressive Agents; Inflammation; Kidney; Kidney Transplantation; Macaca fascicularis; Methotrexate; Swine; Transplantation, Heterologous | 2007 |
A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate.
Topics: Adolescent; Antirheumatic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Methylprednisolone; Polychondritis, Relapsing; Tomography, X-Ray Computed | 2007 |
The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Animals; Antirheumatic Agents; Carrageenan; Gene Expression Regulation, Enzymologic; Inflammation; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2007 |
An index of only patient-reported outcome measures, routine assessment of patient index data 3 (RAPID3), in two abatacept clinical trials: similar results to disease activity score (DAS28) and other RAPID indices that include physician-reported measures.
Topics: Abatacept; Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Evaluation Studies as Topic; Female; Health Status Indicators; Humans; Immunoconjugates; Inflammation; Male; Medical Records; Methotrexate; Multicenter Studies as Topic; Pain Measurement; Patient Participation; Patient Satisfaction; Physicians; Probability; Randomized Controlled Trials as Topic; Range of Motion, Articular; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome | 2008 |
Methotrexate and cyclosporine treatments modify the activities of dipeptidyl peptidase IV and prolyl oligopeptidase in murine macrophages.
Topics: Animals; Cyclosporine; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Therapy, Combination; Enzyme Inhibitors; Immunosuppressive Agents; Inflammation; Macrophages, Peritoneal; Male; Methotrexate; Mice; Pain; Prolyl Oligopeptidases; Serine Endopeptidases | 2008 |
Combined effects of temperature and immunosuppressive drug therapy on allograft rejection in goldfish.
Topics: Animals; Azathioprine; Cyprinidae; Drug Synergism; Inflammation; Methotrexate; Temperature; Transplantation Immunology; Transplantation, Homologous | 1967 |
Functional resistance of inflammatory macrophages to methotrexate in vitro.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Drug Resistance; Inflammation; Kinetics; Macrophages; Male; Methotrexate; Phagocytosis; Protein Biosynthesis; Pseudomonas aeruginosa; Rats; Rats, Inbred Strains; Transcription, Genetic | 1984 |
[Analysis of surface markers on cerebrospinal fluid-producing cells. Contribution to the differential diagnosis of intrathecal lymphomas].
Topics: Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antigens, Surface; Cerebrospinal Fluid; Diagnosis, Differential; Humans; Immunoglobulin kappa-Chains; Inflammation; Lymphocytes; Lymphoma; Male; Methotrexate; Middle Aged; Spinal Cord Neoplasms | 1984 |
New possibilities of cytostatic drug testing on patient tumor cells by flow cytometry.
Topics: Antineoplastic Agents; Ascitic Fluid; Cell Survival; Cells, Cultured; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Evaluation, Preclinical; Esterases; Female; Flow Cytometry; Fluorouracil; Humans; Hydrogen-Ion Concentration; Inflammation; Methotrexate; Neoplastic Stem Cells; Ovarian Neoplasms; Pleural Effusion; Uterine Cervical Neoplasms; Vinblastine; Vindesine | 1984 |
Chemotherapy for metastatic transitional carcinoma of the urinary tract. A prospective trial of methotrexate, adriamycin, and cyclophosphamide (MAC) with cis-platinum for failure.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Inflammation; Leukopenia; Male; Methotrexate; Middle Aged; Mucous Membrane; Prospective Studies; Thrombocytopenia; Urologic Neoplasms | 1983 |
IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Cyclophosphamide; Drug Therapy, Combination; Etoposide; Humans; Ifosfamide; Inflammation; Lymphoma; Methotrexate; Mucous Membrane; Neutropenia; Podophyllotoxin; Recurrence | 1982 |
Ocular irritation from high-dose methotrexate therapy: pharmacokinetics of drug in the tear film.
Topics: Adolescent; Adult; Eye; Eye Diseases; Female; Humans; Inflammation; Irritants; Lacrimal Apparatus; Male; Methotrexate; Middle Aged; Neoplasms; Tears; Time Factors | 1981 |
Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Bone Marrow; Carrageenan; Cell Migration Inhibition; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Leukocyte Count; Male; Methotrexate; Neutrophils; Rats; Time Factors | 1980 |
The enhancement effect of irradiation by methotrexate. Report of three complications.
Topics: Aged; Esophagitis; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Mucous Membrane; Neoplasms; Radiation Injuries; Radiation-Sensitizing Agents | 1980 |
The antiinflammatory effects of methotrexate are mediated by adenosine.
Topics: Acyltransferases; Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Hydroxymethyl and Formyl Transferases; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purinergic P1 Receptor Antagonists; Ribonucleotides; Theobromine; Xanthines | 1994 |
Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Granuloma; Humans; Inflammation; Methotrexate; Preoperative Care; Treatment Outcome | 1994 |
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors | 1993 |
Intravenous immunoglobulin as prophylaxis of chemotherapy-induced oral mucositis.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child, Preschool; Female; Humans; Immunoglobulins, Intravenous; Inflammation; Male; Methotrexate; Mouth Mucosa; Severity of Illness Index | 1997 |
Effects of MTX and BN52021 on PAF-induced chemotaxis of PMNs and intraepidermal accumulation of inflammatory cells in guinea pigs.
Topics: Animals; Chemotaxis, Leukocyte; Dermatologic Agents; Diterpenes; Drugs, Chinese Herbal; Epidermis; Ginkgolides; Guinea Pigs; Inflammation; Lactones; Methotrexate; Neutrophils; Platelet Activating Factor; Random Allocation | 1996 |
Autologous platelet transfusion in patients receiving high-dose chemotherapy and circulating progenitor cell transplantation for stage II/III breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fever; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Inflammation; Methotrexate; Middle Aged; Mucous Membrane; Platelet Count; Platelet Transfusion; Plateletpheresis; Thrombocytopenia; Transplantation Conditioning; Treatment Outcome; Vincristine | 1998 |
Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates.
Topics: Animals; Graft Rejection; Graft Survival; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Inflammation; Lung Neoplasms; Lymphocyte Subsets; Macaca; Methotrexate; Papio; Tacrolimus; Transplantation, Heterologous | 1998 |
Early effective suppression of inflammation in rheumatoid arthritis reduces radiographic progression.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Radiography; Risk Factors; Sulfasalazine | 1998 |
Recurrent inflammation in a site of previous necrotising fasciitis during intravenous CMF chemotherapy.
Topics: Abdomen; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cicatrix; Cyclophosphamide; Fasciitis, Necrotizing; Female; Fluorouracil; Humans; Inflammation; Methotrexate; Middle Aged | 1999 |
Nitric oxide production is increased in patients with inflammatory myositis.
Topics: Adolescent; Adult; Biomarkers; Citrulline; Dermatomyositis; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Nitric Oxide; Nitrites; Polymyositis; Prednisolone; Reference Values | 1999 |
Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvement.
Topics: Anti-Inflammatory Agents; Biopsy; Cavernous Sinus; Chronic Disease; Diabetes Insipidus; Diagnosis, Differential; Diplopia; Humans; Hypopituitarism; Immunosuppressive Agents; Inflammation; Lymphocytes; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Pituitary Gland, Posterior; Plasma Cells; Prednisolone; Trochlear Nerve Diseases | 2001 |
Does mechanical insult to cartilage trigger relapsing polychondritis?
Topics: Adult; Beauty Culture; Cricoid Cartilage; Ear; Ear Cartilage; Female; Glottis; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Needles; Nose; Polychondritis, Relapsing; Prednisone; Treatment Outcome; Wounds, Penetrating | 2001 |
Effects of TGF-alpha gene knockout on epithelial cell kinetics and repair of methotrexate-induced damage in mouse small intestine.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; ErbB Receptors; Inflammation; Intestinal Mucosa; Intestine, Small; Ligands; Methotrexate; Mice; Mice, Knockout; Reference Values; Transforming Growth Factor alpha; Wound Healing | 2002 |
Interaction of methotrexate and betamethasone with experimental phototoxic inflammation to PUVA (Psoralen and UVA) in mice.
Topics: Animals; Betamethasone; Drug Interactions; Female; Ficusin; Furocoumarins; Inflammation; Methotrexate; Mice; Photochemotherapy; Skin; Ultraviolet Rays | 1979 |
The proinflammatory function of lymphocytes in non-immune inflammation: effect of steroidal and non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; In Vitro Techniques; Inflammation; Leukocyte Count; Leukopenia; Lymphocyte Transfusion; Lymphocytes; Male; Methotrexate; Rats | 1977 |
Persistent inflammatory responses enhance the proinflammatory activity of lymphocytes.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Freund's Adjuvant; Inflammation; Leukocyte Count; Leukopenia; Lymphocytes; Male; Methotrexate; Rats | 1978 |
A proinflammatory factor in lymphocytes. Its role in the development of acute, non-immunological inflammatory reactions.
Topics: Animals; Carrageenan; Cell Separation; Dextrans; Edema; Granulocytes; Inflammation; Leukocyte Count; Leukocyte Transfusion; Leukocytes; Leukopenia; Lymphocyte Transfusion; Lymphocytes; Methotrexate; Neutrophils; Rats; Transplantation, Homologous | 1976 |
The role of neutrophils in acute and chronic inflammation in rats.
Topics: Acute Disease; Animals; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Animal; Edema; Freund's Adjuvant; Histamine; Inflammation; Leukocyte Count; Male; Methotrexate; Neutropenia; Neutrophils; Rats; Rats, Wistar | 1992 |
Low-dose methotrexate therapy for ocular inflammatory disease.
Topics: Adolescent; Adult; Aged; Chronic Disease; Dosage Forms; Eye Diseases; Female; Follow-Up Studies; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies | 1992 |
[Experimental histological study of the local toxicity of intra-tubal injections of methotrexate].
Topics: Animals; Biopsy; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Infertility, Female; Inflammation; Injections; Injections, Subcutaneous; Methotrexate; Peritoneal Diseases; Pregnancy; Pregnancy, Tubal; Rabbits | 1992 |
Do lymphocytes play a pro-inflammatory role in any pharmacological type of rat paw edema?
Topics: Animals; Carrageenan; Dextrans; Edema; Hindlimb; Inflammation; Kaolin; Leukocyte Count; Leukopenia; Lymphocyte Depletion; Lymphocytes; Male; Methotrexate; Rats; Rats, Inbred Strains | 1989 |
Short term effects of low dose methotrexate on the acute phase reaction in patients with rheumatoid arthritis.
Topics: Acute-Phase Reaction; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Drug Administration Schedule; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Time Factors | 1989 |
MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma.
Topics: Actuarial Analysis; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Arachnoid; Bleomycin; Bone Marrow; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Inflammation; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Mucous Membrane; Neoplasm Staging; Pia Mater; Prednisone; Vincristine | 1985 |
Further studies of the mechanism of counter irritation by turpentine.
Topics: Animals; Blood Sedimentation; Captopril; Carrageenan; Edema; Female; Inflammation; Kininogens; Leukopenia; Male; Methotrexate; Methysergide; Pyrilamine; Rats; Rats, Inbred Strains; Turpentine; Zymosan | 1986 |
Mast cell numbers in rheumatoid synovial tissues. Correlations with quantitative measures of lymphocytic infiltration and modulation by antiinflammatory therapy.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cell Count; Humans; Immunoenzyme Techniques; Inflammation; Injections, Intra-Articular; Knee Joint; Lymphocytes; Mast Cells; Methotrexate; Plasma Cells; Synovial Membrane | 1987 |
Influence of prednisolone and methotrexate on cellular and biochemical aspects of acute and chronic inflammation studied in subcutaneously implanted sponges in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chronic Disease; Collagen; Glycosaminoglycans; Hydroxyproline; Inflammation; Male; Methotrexate; Prednisolone; Rats; Rats, Inbred Strains; Uronic Acids | 1986 |
Measures of immunologic and inflammatory responses in vitro in rheumatoid patients treated with methotrexate.
Topics: Antibody Formation; Arthritis, Rheumatoid; DNA Replication; Esterases; Humans; Immunity, Cellular; Inflammation; Methotrexate; Monocytes | 1986 |
The effect of low dose chronic intermittent parental methotrexate on delayed type hypersensitivity and acute inflammation in a mouse model.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Hypersensitivity, Delayed; Immunosuppression Therapy; Inflammation; Methotrexate; Mice; Mice, Inbred BALB C; Time Factors | 1986 |
Primary chemotherapy in the treatment of inflammatory breast carcinoma: a study of 230 cases from the Institut Gustave-Roussy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; France; Humans; Inflammation; Methotrexate; Vincristine | 1986 |
Involvement of lymphocytes in non-immune inflammation: dual effect of glucocorticoids.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Carrageenan; Glucocorticoids; Inflammation; Leukopenia; Lymphocyte Transfusion; Lymphocytes; Male; Methotrexate; Metyrapone; Rats; Rats, Inbred Strains | 1985 |
Studies on the effect of low dose methotrexate on rat adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Drug Evaluation, Preclinical; Female; Inflammation; Male; Methotrexate; Rats | 1985 |
Effect of predosing animals with immunosuppressive drugs on immune and non-immune induced inflammatory responses.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Azathioprine; Carrageenan; Cyclophosphamide; Dexamethasone; Edema; Graft vs Host Reaction; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Rats | 1974 |
Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.
Topics: 5-Hydroxytryptophan; Albumins; Animals; Anti-Inflammatory Agents; Carrageenan; Cellulose; Complement System Proteins; Edema; Histamine; Histamine H1 Antagonists; Immune Sera; Inflammation; Iodine Isotopes; Iproniazid; Kinins; Leukocytes; Male; Methotrexate; p-Methoxy-N-methylphenethylamine; Pleurisy; Prostaglandins; Rabbits; Rats; Turpentine | 1971 |
[Wegener's granulomatosis. Contribution to the diagnosis, therapy and course].
Topics: Aged; Chlorambucil; Cyclophosphamide; Female; Glomerulonephritis; Granulomatosis with Polyangiitis; Humans; Inflammation; Male; Methotrexate; Middle Aged; Prednisone; Vascular Diseases | 1974 |
Acute inflammation and granulation tissue formation in neutropenic rats.
Topics: Agranulocytosis; Animals; Carbon; Colloids; Dental Plaque; Exudates and Transudates; Female; Filtration; Granulation Tissue; Inflammation; Leukocyte Count; Methotrexate; Rats; Wound Healing | 1974 |
[Some rare pulmonary complications in leukemic children during full haematological remission].
Topics: Adolescent; Asparaginase; Candidiasis; Child; Child, Preschool; Daunorubicin; Humans; Inflammation; Leukemia, Lymphoid; Lung Diseases, Fungal; Male; Methotrexate; Pulmonary Alveoli; Remission, Spontaneous; Vincristine | 1974 |
On methotrexate treatment of psoriasis. Model of a cytostatics treatment.
Topics: Age Factors; Alopecia; Atrophy; Carcinoma, Basal Cell; Diarrhea; Gastritis; Gastrointestinal Hemorrhage; Gingival Diseases; Gingivitis, Necrotizing Ulcerative; Humans; Immunologic Deficiency Syndromes; Immunosuppression Therapy; Infections; Inflammation; Methotrexate; Nausea; Psoriasis; Skin Neoplasms; Stomatitis, Aphthous | 1972 |
[The effect of various antibiotics, corticosteroids and cytostatic preparations on the morphology of experimental aspergillosis].
Topics: Animals; Antineoplastic Agents; Aspergillosis; Aspergillus fumigatus; Brain; Chlortetracycline; Cyclophosphamide; Dexamethasone; Fluorouracil; Hydrocortisone; Inflammation; Kidney; Liver; Lung; Mercaptopurine; Methotrexate; Mice; Myocardium; Penicillin V; Spleen; Streptomycin | 1972 |
The effect of various immunosuppressive agents on the vascular and cellular response to carvageenan in the rat.
Topics: Animals; Azathioprine; Busulfan; Carrageenan; Chlorambucil; Cyclophosphamide; Edema; Immunosuppressive Agents; Inflammation; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Rats; Time Factors | 1973 |
The pathogenesis of folic acid deficiency in man.
Topics: Adolescent; Adult; Aged; Alcoholism; Anemia, Macrocytic; Animals; Anticonvulsants; Celiac Disease; Child; Diet; Female; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Inflammation; Liver; Male; Metabolic Diseases; Methotrexate; Neoplasms; Pregnancy | 1974 |
[Study of the inflammatory response in rat and guinea pig].
Topics: Agranulocytosis; Animals; Complement System Proteins; Guinea Pigs; Hypersensitivity, Delayed; Inflammation; Methotrexate; Rats | 1970 |
Mechanism of eosinophilia. IX. Induction of eosinophilia in rats by certain forms of dextran.
Topics: Animals; Colloids; Dextrans; Eosinophilia; Eosinophils; Immunosuppressive Agents; Inflammation; Injections, Intravenous; Ion Exchange Resins; Leukocyte Count; Leukocytosis; Lung; Methotrexate; Neutrophils; Prednisolone; Rats; Rats, Inbred Strains | 1972 |
Release of lysosomal enzymes in experimental inflammations: effects of anti-inflammatory drugs.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; Carrageenan; Dexamethasone; Edema; Female; Glucuronidase; Hexosaminidases; Indomethacin; Inflammation; Lysosomes; Methotrexate; Nystatin; Phenylbutazone; Prednisolone; Rats; Time Factors | 1972 |
Studies on the antiphlogistic activity of cytostatics.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Carrageenan; Chloramphenicol; Cyclophosphamide; Dextrans; Edema; Fluorouracil; Foot; Hydrolysis; Indomethacin; Inflammation; Leukocyte Count; Male; Methotrexate; Penicillamine; Phenylbutazone; Rats; Triaziquone | 1972 |
A comparison of immunosuppressive and anti-inflammatory agents in the rat.
Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Antilymphocyte Serum; Arthritis; Azathioprine; Chlorambucil; Cyclophosphamide; Erythrocytes; Female; Freund's Adjuvant; Hindlimb; Hydrocortisone; Hypersensitivity, Delayed; Immunosuppressive Agents; Inflammation; Male; Methotrexate; Phenylbutazone; Rats; Sheep; Tuberculin Test | 1971 |
Peripheral retinitis and chronic cyclitis in children.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Chorioretinitis; Ciliary Body; Diagnosis, Differential; Diathermy; Eye Diseases; Female; Humans; Inflammation; Male; Methotrexate; Methylprednisolone; Prednisone; Retinitis; Uveitis, Anterior | 1965 |
The role of polymorphonuclear leucocytes in acute inflammation in agranulocytic rats.
Topics: Agranulocytosis; Animals; Anti-Inflammatory Agents; Basophils; Burns; Complement System Proteins; Eosinophils; Immune Sera; Inflammation; Leukocytes; Methotrexate; Neutrophils; Pleurisy; Rabbits; Rats; Trypan Blue; Turpentine | 1969 |
The anti-inflammatory effect of some immunosuppressive agents.
Topics: Animals; Anti-Inflammatory Agents; Antilymphocyte Serum; Burns; Capillary Permeability; Immune Sera; Immunosuppressive Agents; Inflammation; Lectins; Leukocyte Count; Lymph Nodes; Mercaptopurine; Methotrexate; Pleurisy; Rats; Turpentine | 1969 |
Inflammation in agranulocytotic rats.
Topics: Agranulocytosis; Animals; Burns; Capillary Permeability; Complement System Proteins; Inflammation; Leukocyte Count; Lysosomes; Methotrexate; Neutrophils; Pleurisy; Rats; Turpentine | 1968 |
An analysis of the multiplicity of the effects of antilymphocyte serum. A comparison with the action of other immunosuppressive agents in the cell-mediated immune response and non-specific inflammation.
Topics: Antibody Formation; Antilymphocyte Serum; Cell Differentiation; Complement Inactivator Proteins; Cyclophosphamide; Hydrolases; Immune Sera; Immunosuppressive Agents; Inflammation; Lymphocytes; Methotrexate; Microscopy, Electron; Phagocytosis; Thalidomide | 1969 |
Reactivation of acute inflammation by methotrexate.
Topics: Erythema; Female; Humans; Inflammation; Male; Methotrexate; Photosensitivity Disorders; Psoriasis; Radiation Effects; Skin; Ultraviolet Rays | 1969 |
Inhibition of the local inflammatory response in man by antimetabolites.
Topics: Antimetabolites; Humans; Inflammation; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Uveitis | 1966 |