Page last updated: 2024-08-25

methotrexate and Glioma

methotrexate has been researched along with Glioma in 124 studies

Research

Studies (124)

Timeframe	Studies, this research(%)	All Research%
pre-1990	70 (56.45)	18.7374
1990's	26 (20.97)	18.2507
2000's	12 (9.68)	29.6817
2010's	10 (8.06)	24.3611
2020's	6 (4.84)	2.80

Authors

Authors	Studies
Bhandari, A; Kaur, G; Kaur, H; Kaur, M; Sharma, I; Singh, H; Singh, P	1
Iqbal, M; Mehmood, T	1
Atrakchi, D; Cooper, I; Daniels, D; Guez, D; Last, D; Liraz-Zaltsman, S; Mardor, Y; Sharabi, S	1
Alderete, JB; Díaz, CF; Guzmán, JL; Jiménez, VA; Ortiz, N; Vásquez, PA; Vidal, F	1
Adnan, F; Ayub, S; Iqbal, M; Kalsoom, S; Kamal, MA; Khan, IN; Malik, SA; Nemat, A	1
Davy, A; Fawal, MA; Jungas, T	1
Battastini, AMO; de Fraga Dias, A; Figueiró, F; Lopes, DV; Scholl, JN; Sévigny, J; Silva, LFL	1
Baidya, A; He, Y; Li, YS; Lu, ST; Mei, H; Wu, B; Xu, D	1
Alsadeq, A; Ben-Batalla, I; Cario, G; Fedders, H; Krause, S; Loges, S; Möricke, A; Pfeiffer, C; Schewe, DM; Schrappe, M; Stanulla, M; Strube, S; Vokuhl, C; Waizenegger, J	1
Cooper, I; Daniels, D; Elhaik Goldman, S; Fridkin, M; Guez, D; Last, D; Lubitz, I; Mardor, R; Mardor, Y; Salomon, S; Sharabi, S; Shechter, Y; Tamar, G; Tamir, T	1
Garg, NK; Jain, A; Katare, OP; Singh, B; Soni, V; Tyagi, RK; Webster, TJ	1
Corde, S; Konstantinov, K; Lerch, ML; Oktaria, S; Rosenfeld, AB; Tehei, M	1
Cooper, I; Fridkin, M; Shechter, Y	1
Annovazzi, L; Battaglia, L; Biasibetti, E; Capucchio, MT; Chirio, D; Gallarate, M; Lanotte, M; Mellai, M; Muntoni, E; Panciani, P; Peira, E; Riganti, C; Salaroglio, IC; Schiffer, D; Valazza, A	1
Blakeley, JO; Grossman, SA; He, X; Olson, J; Supko, JG; Weingart, J	1
Chandra, H; Kumar, N; Mishra, AK; Mishra, P; Shukla, G; Sinha, D; Tiwari, AK	1
Adamkiewicz-Drozynska, E; Balcerska, A; Bien, E; Dubaniewicz-Wybieralska, M; Krawczyk, M; Stachowicz-Stencel, T; Synakiewicz, A; Szalewska, M; Zielinski, P	1
Estlin, EJ; McGown, A; Najim, N; Podmore, ID	1
Kortmann, RD; Kramm, C; Peters, O; Pietsch, T; Rutkowski, S; Schmid, HJ; Warmuth-Metz, M; Wolff, B; Wolff, JE	1
Furubayashi, T; Inoue, D; Katsumi, H; Sakane, T; Shingaki, T; Yamamoto, A; Yamashita, S	1
WINTER, A	1
ONESTI, P; WOODLIFF, HJ	1
BELLMAN, S; HUGOSSON, R; JOHANSSON, B; SJOEGREN, SE	1
Alipour, M; Eibl, H; Erdlenbruch, B; Fricker, G; Kugler, W; Lakomek, M; Miller, DS	1
Lehnert, S; Li, Y; Owusu, A	1
Bruns, PK; Daman, M; Doolittle, ND; Fortin, D; Hall, WA; Muldoon, L; Neuwelt, EA	1
Barth, RF; Green-Church, K; Kawabata, S; Wu, G; Yang, W; Zhang, L	1
Fang, C; Fichtenholtz, A; Gunn, J; Kohler, N; Sun, C; Zhang, M	1
Altinoz, MA; Bilir, A; Del Maestro, RF; Gedikoglu, G; Ozcan, E; Ozdilli, K; Sav, A	1
Norrell, H; Wilson, C	1
Frenkel, EP; Hill, SA; Neuwelt, EA	1
Barnett, PA; Frenkel, EP; Neuwelt, EA	1
Barnett, PA; Bigner, DD; Frenkel, EP; Neuwelt, EA	1
Arnal, F; Humeau, C; Sentein, P; Vic, P; Vlahovitch, B	1
Ishiwata, Y; Kuwabara, T; Kyuma, Y; Murai, M; Nishimura, S; Shinonaga, M; Yamashita, T	1
Flament, H; Grisold, W; Jellinger, K; Volc, D; Vollmer, R; Weiss, R	1
Neuwelt, EA; Rapoport, SI	1
Diehl, JT; Frenkel, EP; Hill, SA; Michael, AJ; Neuwelt, EA; Vu, LH	1
Hill, SA; Neuwelt, EA	1
Arai, S; Azuma, E; Hirai, S; Hirota, H; Inoue, M; Kamiya, H; Kato, M; Kawabe, Y; Kawai, K; Kazuoka, K; Komada, Y; Matsuda, T; Nakabayashi, T; Nakano, C; Nobori, T; Nomura, T; Ogiwara, T; Sakurai, M; Shibata, T; Shimizu, S; Uejima, A	1
Flament, H; Grisold, W; Jellinger, K; Podreka, I; Volc, D; Vollmer, R; Weiss, R	1
Brem, H; Colvin, OM; Dang, W; Saltzman, WM	1
Devineni, D; Gallo, JM; Klein-Szanto, A	2
Haug, BA; Krygier-Stojalowska, A; Pilichowska, ME; Schröter, P	1
Kumazaki, T; Nakazawa, S; Node, Y; Shimura, T; Takahashi, H; Tamai, J	1
Arnold, H; Bjerkvig, R; Fiskerstrand, T; Refsum, H; Terzis, AJ; Ueland, PM	1
Chio, CC; Lin, MT; Lin, SJ	1
Aihara, K; Shimura, T; Teramoto, A	1
Dichgans, J; Roth, W; Schmidt, C; Weller, M	1
Lanzafame, RJ; LoRusso, AP; Naim, JO; Yu, W	1
Barral, FG; Beauchesne, P; Clavreul, G; Duthel, R; Laurent, B; Pialat, J; Schmitt, T	1
Black, P; Finkelstein, SD; Hand, CM; Vender, JR	1
Hori, S; Mori, T; Morikawa, N; Takeyama, M	1
Benesch, M; Kerbl, R; Lackner, H; Oberbauer, R; Pakisch, B; Schwinger, W; Urban, C	1
Aghi, M; Breakefield, XO; Kramm, CM	1
Dukic, S; Gourdier, B; Heurtaux, T; Hoizey, G; Kaltenbach, ML; Lallemand, A; Vistelle, R	1
Defanti, CA; Landonio, G; Riva, M; Siena, S	1
Kong, L; Wang, H; Xue, H; Zhou, H	1
Altinoz, MA; Bilir, A; Onar, FD; Ozar, E; Sav, A	1
Romodanov, AP; Sceglov, VI; Sosnov, JD; Verchogljadova, TP; Zozulja, JA	1
Abelson, HT; Fosburg, M; Gorka, C; Kornblith, P	1
de Tribolet, N; Zander, E	1
Boesel, C; Ertel, IJ	1
Heiss, WD; Mamoli, B; Turnheim, M	1
Ghavimi, F; Mehta, BM; Mosende, C; Nirenberg, A; Rosen, G	1
Shapiro, WR	4
Allen, JC; Pentlow, KS; Rottenberg, DA; Thaler, HT	1
Dieterich, E; Gutjahr, P	1
Oster, MW	1
Goldstein, MN; Kolber, AR; Moore, BW; Perumal, AS	1
Levin, VA; Wilson, CB	1
Day, A; So, WS; Tator, CH; Wassenaar, W	1
Diemath, HE	2
Garfield, JS	1
Wilson, CB	1
Posner, JB; Shapiro, WR	1
Grant, R; Greenberg, HS; Junck, L; Naylor, B	1
Boiardi, A; Croci, D; Perego, E; Silvani, A; Solero, CL	1
Ikeda, Y; Nakazawa, S; Node, Y; Shimura, T	1
Belshe, BD; Gumerlock, MK; Madsen, R; Watts, C	1
Cohen, ME; Duffner, PK	1
Merchant, RE; Watts, RG	1
Henderson, GB; Strauss, BP	1
Hayashi, A; Kyuma, Y	1
Bauer, S; Remmele, T; Stricker, H; Sturm, V; Wowra, B; Zeller, WJ	1
Benoit, B; Grahovac, Z; Hugenholtz, H; Richard, M; Russell, N; Stewart, DJ	1
Arita, N; Hayakawa, T; Mogami, H; Ushio, Y	1
Mealey, J; Shapiro, S	1
Mabuchi, E; Matsui, Y; Mogami, H; Moriuchi, S; Park, K; Shimizu, K; Tamura, K; Yamada, M	1
Kageyama, N; Kito, A; Kojima, N; Yagi, K; Yoshida, J	1
Abernathey, CD; Kooistra, KL; Laws, ER; Wilcox, GL	1
Shapiro, JR; Shapiro, WR	1
Dahlborg, SA; Klein, ML; Millay, RH; Neuwelt, EA; Shults, WT	1
Binder, H; Deecke, L; Dittrich, C; Heimberger, K; Hiesmayr, M; Podreka, I; Reisner, T; Samec, P; Steger, G; Suess, E	1
Antuña García, MJ; Fernández, C; Gudín, G; López Sastre, J; Moro Bayón, C; Rodríguez, R	1
Dingeldein, E; Jansen, J; Mandel, T; Mennel, HD; Rama, B	1
Basler, GA; Hiesiger, EM; Lipschutz, LE; Shapiro, WR; Sher, PB; Voorhies, RM	1
Allen, JC; Caparros, B; Rosen, G; Walker, RW	1
Amadori, S; Fontana, M; Mandelli, F; Meloni, G; Pompili, A; Riccio, A; Rubinstein, LJ; Stanton, C	1
Fujiwara, T; Furuta, T; Rosenfeld, SA; Wilkinson, HA	1
Barlow, CF; Cutler, RW; Lorenzo, AV; Watters, GV	1
Broder, LE; Rall, DP	1
Handa, H; Mori, K; Onoyama, Y	1
Hoshino, T; Nagai, M; Sano, K	1
Sato, O	1
Billet, M; Frerebeau, P; Gros, C; Ouaknine, G; Vlahovitch, B	1
Barker, M; Gordan, GS; Lubich, W; Marton, LJ; Wilson, CB	1
Jacobi, H	1
Heiss, WD; Kroiss, A; Kühböck, J; Profanter, W	1
Hayakawa, T; Mogami, H; Ushio, Y	1
Deck, M; Ghavimi, F; Murphy, ML; Rosen, G; Tan, C; Vanucci, R	1
Goldstein, MN; Silbert, SW	1
Chernik, NL; Posner, JB; Shapiro, WR	1
Nogales, FF; Oliva, HA	1
Mahaley, MS; Woodhall, B	1
Sayers, MP	1
Tator, CH	1
Bagan, M; Bering, EA; Gieseke, FG; Henderson, ES; Ommaya, AK; Rall, DP; Rubin, RC	1
Ausman, JI; Rall, DP; Shapiro, WR	1

Reviews

8 review(s) available for methotrexate and Glioma

Article	Year
Poor-risk high-grade gliomas in three survivors of childhood acute lymphoblastic leukaemia--an overview of causative factors and possible therapeutic options. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009, Volume: 25, Issue:5 Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Child; Child, Preschool; Cranial Irradiation; Female; Glioma; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy, Adjuvant; Risk Factors; Supratentorial Neoplasms; Survivors; Treatment Outcome	2009
Aggressive treatment with complete remission in primary diffuse leptomeningeal gliomatosis--a case report. Journal of neuro-oncology, 1998, Volume: 37, Issue:2 Topics: Adolescent; Antimetabolites, Antineoplastic; Cerebrospinal Fluid Shunts; Combined Modality Therapy; Glioma; Humans; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Remission Induction	1998
Chemotherapy: the agents in current use. Seminars in oncology, 1975, Volume: 2, Issue:1 Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Dacarbazine; Drug Therapy, Combination; Glioma; Humans; Lomustine; Medulloblastoma; Methotrexate; Nitrogen Mustard Compounds; Procarbazine; Semustine; Teniposide; Vincristine	1975
Changes in the approach to central nervous system tumors in childhood. Pediatric clinics of North America, 1992, Volume: 39, Issue:4 Topics: Brain; Brain Diseases; Brain Neoplasms; Child; Glioma; Humans; Medulloblastoma; Methotrexate; Radiation Injuries	1992
Late anaplastic gliomas in children previously treated for acute lymphoblastic leukemia. Pediatric neuroscience, 1989, Volume: 15, Issue:4 Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Glioma; Humans; Infant; Methotrexate; Neoplasms, Radiation-Induced; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy	1989
Principles of brain tumor chemotherapy. Seminars in oncology, 1986, Volume: 13, Issue:1 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Carbon Radioisotopes; Carmustine; Cell Line; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance; Fluorouracil; Glioma; Humans; Hydroxyurea; Infusions, Intra-Arterial; Karyotyping; Kinetics; Mannitol; Methotrexate; Podophyllotoxin; Procarbazine; Rats; Tumor Stem Cell Assay	1986
Chemotherapy of brain tumors. Progress in experimental tumor research, 1972, Volume: 17 Topics: Adult; Antineoplastic Agents; Azaguanine; Bleomycin; Brain Neoplasms; Child; Cyclophosphamide; Drug Synergism; Fluorouracil; Glioblastoma; Glioma; Humans; Hydroxyurea; Medulloblastoma; Methotrexate; Nitrogen Mustard Compounds; Nitrosourea Compounds; Plicamycin; Procarbazine; Streptonigrin; Vinblastine; Vincristine	1972
[Chemotherapy of brain neoplasms in children]. Zeitschrift fur Allgemeinmedizin, 1974, Sep-10, Volume: 50, Issue:25 Topics: Age Factors; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Child; Cyclophosphamide; Drug Therapy, Combination; Ependymoma; Glioblastoma; Glioma; Humans; Medulloblastoma; Methotrexate; Nitrosourea Compounds; Prognosis; Radiotherapy Dosage; Time Factors; Vincristine	1974

Trials

7 trial(s) available for methotrexate and Glioma

Article	Year
Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. Journal of neuro-oncology, 2009, Volume: 91, Issue:1 Topics: Adult; Aged; Area Under Curve; Blood-Brain Barrier; Brain Neoplasms; Chromatography, High Pressure Liquid; Female; Glioma; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Mass Spectrometry; Methotrexate; Microdialysis; Middle Aged; Time Factors	2009
High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D pilot study. Journal of neuro-oncology, 2011, Volume: 102, Issue:3 Topics: Adolescent; Brain Neoplasms; Chi-Square Distribution; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Female; Glioma; Humans; Immunosuppressive Agents; Male; Methotrexate; Pilot Projects; Survival Analysis; Treatment Outcome	2011
[Combined treatment of malignant gliomas]. Wiener klinische Wochenschrift, 1983, Jun-10, Volume: 95, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cobalt Radioisotopes; Drug Therapy, Combination; Female; Glioma; Humans; Lomustine; Male; Methotrexate; Middle Aged; Prednisone; Procarbazine; Radioisotope Teletherapy; Vincristine	1983
Intra-arterial chemotherapy following blood-brain barrier disruption in a patient with malignant glioma. Journal of neurosurgical nursing, 1982, Volume: 14, Issue:2 Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Clinical Trials as Topic; Female; Glioma; Humans; Infusions, Intra-Arterial; Mannitol; Methotrexate; Middle Aged; Tomography, X-Ray Computed	1982
Malignant gliomas--ploidy and DNA-content before and after therapy. Zentralblatt fur Pathologie, 1994, Volume: 140, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Diploidy; DNA, Neoplasm; Female; Glioma; Humans; Male; Methotrexate; Middle Aged; Ploidies; Polyploidy; Prednisone; Radiotherapy Dosage; Vincristine	1994
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults. Journal of neuro-oncology, 1998, Volume: 39, Issue:1 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Deafness; Disease Progression; Disease-Free Survival; Etoposide; Follow-Up Studies; Glioma; Hearing Loss; Hematologic Diseases; Humans; Ifosfamide; Infections; Life Tables; Lomustine; Medulloblastoma; Methotrexate; Prognosis; Radiotherapy, Adjuvant; Remission Induction; Vincristine	1998
Opening blood-brain-barrier by intracarotid infusion of papaverine in treatment of malignant cerebral glioma. Chinese medical journal, 1998, Volume: 111, Issue:8 Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Carotid Artery, Internal; Child; Female; Glioblastoma; Glioma; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Papaverine; Vasodilator Agents	1998

Other Studies

109 other study(ies) available for methotrexate and Glioma

Article	Year
Structural tuning of acridones for developing anticancer agents targeting dihydrofolate reductase. Bioorganic & medicinal chemistry letters, 2019, 10-01, Volume: 29, Issue:19 Topics: Acridones; Antineoplastic Agents; Apoptosis; Cell Proliferation; Enzyme Inhibitors; Glioma; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	2019
Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives. Scientific reports, 2021, 09-21, Volume: 11, Issue:1 Topics: Antineoplastic Agents; Brain Neoplasms; Cell Survival; Glioma; Humans; Least-Squares Analysis; Methotrexate	2021
The application of point source electroporation and chemotherapy for the treatment of glioma: a randomized controlled rat study. Scientific reports, 2020, 02-07, Volume: 10, Issue:1 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cisplatin; Electroporation; Glioma; Male; Methotrexate; Random Allocation; Rats; Rats, Inbred Lew	2020
Polyamidoamine-based nanovector for the efficient delivery of methotrexate to U87 glioma cells. Nanomedicine (London, England), 2020, Volume: 15, Issue:28 Topics: Dendrimers; Drug Delivery Systems; Glioma; Humans; Methotrexate; Polyamines	2020
Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines. Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:7 Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Drug Screening Assays, Antitumor; Glioma; Humans; Methotrexate; Molecular Docking Simulation; Molecular Structure; Schiff Bases; Structure-Activity Relationship	2022
Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells. Cancer letters, 2021, 04-10, Volume: 503 Topics: Brain Neoplasms; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Gene Expression Regulation, Neoplastic; Glioma; Humans; Methotrexate; Neoplastic Stem Cells; Organoids; Prognosis; Tetrahydrofolate Dehydrogenase; Up-Regulation	2021
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth. Purinergic signalling, 2021, Volume: 17, Issue:2 Topics: 5'-Nucleotidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glioblastoma; Glioma; Male; Methotrexate; Monocytes; Rats; Rats, Wistar	2021
Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment. Drug design, development and therapy, 2018, Volume: 12 Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Proliferation; Cell Survival; Contrast Media; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Gadolinium; Glioma; Humans; Magnetic Resonance Imaging; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Organometallic Compounds; Structure-Activity Relationship	2018
Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS). Blood, 2015, Jan-29, Volume: 125, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Blood Proteins; c-Mer Tyrosine Kinase; Case-Control Studies; Cell Survival; Central Nervous System; Child; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Coculture Techniques; Female; Galectin 3; Galectins; Gene Expression Regulation, Leukemic; Glioma; Humans; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Translocation, Genetic; Tumor Cells, Cultured	2015
Combined local blood-brain barrier opening and systemic methotrexate for the treatment of brain tumors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015, Volume: 35, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Line; Convection; Drug Delivery Systems; Ethylamines; Glioma; Humans; Male; Methotrexate; Rats; Rats, Inbred Lew; Serum Albumin; Swine	2015
Surface engineered polymeric nanocarriers mediate the delivery of transferrin-methotrexate conjugates for an improved understanding of brain cancer. Acta biomaterialia, 2015, Volume: 24 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glioma; Methotrexate; Nanocapsules; Rats; Rats, Wistar; Surface Properties; Transferrin	2015
Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy. Physics in medicine and biology, 2015, Oct-21, Volume: 60, Issue:20 Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Combined Modality Therapy; DNA Repair; Flow Cytometry; Glioma; Methotrexate; Photons; Radiation-Sensitizing Agents; Rats; X-Rays	2015
Conjugation of Methotrexate-Amino Derivatives to Macromolecules through Carboxylate Moieties Is Superior Over Conventional Linkage to Amino Residues: Chemical, Cell-Free and In Vitro Characterizations. PloS one, 2016, Volume: 11, Issue:7 Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cattle; Cell Line, Tumor; Cysteine; Glioma; Humans; Hydrogen-Ion Concentration; Hydrolysis; Methotrexate; Peptides; Polyethylene Glycols; Serum Albumin, Bovine	2016
Solid lipid nanoparticles by coacervation loaded with a methotrexate prodrug: preliminary study for glioma treatment. Nanomedicine (London, England), 2017, Volume: 12, Issue:6 Topics: Animals; Apoptosis; Cell Line, Tumor; Drug Carriers; Glioma; Humans; Lipids; Methotrexate; Nanoparticles; Prodrugs; Rats; Tissue Distribution	2017
Polyethylene glycol conjugates of methotrexate and melphalan: synthesis, radiolabeling and biologic studies. Cancer biotherapy & radiopharmaceuticals, 2008, Volume: 23, Issue:5 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Glioma; Humans; Hydrogen-Ion Concentration; Kinetics; Melphalan; Methotrexate; Mice; Polyethylene Glycols; Polymers; Tissue Distribution	2008
Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines. Anticancer research, 2009, Volume: 29, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Cerebellar Neoplasms; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fluorometry; Glioma; Glutathione; Humans; Medulloblastoma; Methionine; Methotrexate; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins	2009
Transnasal delivery of methotrexate to brain tumors in rats: a new strategy for brain tumor chemotherapy. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Administration, Intranasal; Animals; Antineoplastic Agents; Biological Transport, Active; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Glioma; Injections, Intraperitoneal; Male; Methotrexate; Models, Biological; Rats; Rats, Wistar	2010
Infusion chemotherapy for brain and neck cancer. The Journal of the Medical Society of New Jersey, 1963, Volume: 60 Topics: Brain; Brain Neoplasms; Glioma; Head and Neck Neoplasms; Humans; Methotrexate; Thiotepa	1963
EFFECT OF DRUGS ON CELLS IN VITRO. British medical journal, 1963, Dec-14, Volume: 2, Issue:5371 Topics: Animals; Busulfan; Glioma; In Vitro Techniques; Leukemia; Leukemia, Experimental; Leukemia, Myeloid; Mannitol; Methotrexate; Mice; Nitrogen Mustard Compounds; Pharmacology; Research	1963
CHEMOTHERAPY OF FIVE SUPRATENTORIAL MALIGNANT GLIOMAS WITH INTRA-ARTERIAL INFUSION OF METHOTREXATE. Acta chirurgica Scandinavica, 1964, Volume: 127 Topics: Aphasia; Brain Neoplasms; Carotid Arteries; Cerebral Angiography; Drug Therapy; Glioma; Humans; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Necrosis; Paralysis; Parietal Lobe; Surgical Procedures, Operative; Temporal Lobe	1964
Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. British journal of pharmacology, 2003, Volume: 140, Issue:7 Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Blood-Brain Barrier; Brain; Brain Neoplasms; Capillaries; Fluorescein; Fluorescent Dyes; Glioma; Glycerol; Injections, Intra-Arterial; Injections, Intraventricular; Male; Methotrexate; Mice; Mice, Nude; Microscopy, Confocal; Neoplasm Transplantation; Rats; Rats, Wistar; Tissue Distribution	2003
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Combined Modality Therapy; Drug Combinations; Drug Implants; Fluorouracil; Glioma; Immunologic Factors; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Rats	2004
Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas. Journal of neuro-oncology, 2006, Volume: 77, Issue:3 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Stem Neoplasms; Carboplatin; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Drug Delivery Systems; Etoposide; Female; Glioma; Humans; Male; Methotrexate; Osmosis; Retrospective Studies; Treatment Outcome	2006
Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates. Molecular cancer therapeutics, 2006, Volume: 5, Issue:1 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Binding, Competitive; Brain; Brain Neoplasms; Cetuximab; Dendrimers; Drug Delivery Systems; ErbB Receptors; Glioma; Methotrexate; Polyamines; Rats; Rats, Inbred F344; Tissue Distribution; Toxicity Tests	2006
Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery. Small (Weinheim an der Bergstrasse, Germany), 2006, Volume: 2, Issue:6 Topics: Adsorption; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Coated Materials, Biocompatible; Contrast Media; Drug Delivery Systems; Glioma; Image Enhancement; Magnetic Resonance Imaging; Magnetics; Methotrexate; Nanoparticles; Polyethylene Glycols; Radionuclide Imaging; Rats	2006
Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro. The International journal of neuroscience, 2007, Volume: 117, Issue:10 Topics: Animals; Antidepressive Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cisplatin; Drug Resistance, Neoplasm; Glioma; In Vitro Techniques; Lysosomes; Medroxyprogesterone Acetate; Methotrexate; Microscopy, Electron; Myelin Sheath; Phospholipids; S Phase; Thymidine; Tumor Stem Cell Assay	2007
Brain tumor chemotherapy with methotrexate given intrathecally. A new technique. JAMA, 1967, Jul-03, Volume: 201, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Aged; Brain Neoplasms; Child; Ependymoma; Glioma; Humans; Injections, Spinal; Lymphoma; Medulloblastoma; Melanoma; Methotrexate	1967
Osmotic blood-brain barrier modification and combination chemotherapy: concurrent tumor regression in areas of barrier opening and progression in brain regions distant to barrier opening. Neurosurgery, 1984, Volume: 15, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Cyclophosphamide; Female; Glioma; Humans; Leucovorin; Lymphoma; Male; Mannitol; Methotrexate; Procarbazine; Tomography, X-Ray Computed; Water-Electrolyte Balance	1984
Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: observations on problems of drug delivery. Neurosurgery, 1984, Volume: 14, Issue:2 Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Bleomycin; Blood-Brain Barrier; Brain; Brain Neoplasms; Cyclophosphamide; Fluorouracil; Glioma; Methotrexate; Osmosis; Rats; Rats, Inbred F344; Tumor Virus Infections	1984
Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:14 Topics: Alpharetrovirus; Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Dexamethasone; Glioma; Mannitol; Methotrexate; Neoplasms, Experimental; Rats; Rats, Inbred F344	1982
[Effects of various antimitotics on cultured human glioma : demonstration of 2 types of simultaneous morphologic involvement, specific and nonspecific]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1981, Volume: 175, Issue:2 Topics: Antineoplastic Agents; Cell Cycle; Cells, Cultured; Glioma; Humans; Methotrexate; Microscopy, Electron; Mitosis; Thiotepa; Vinblastine; Vincristine	1981
[Chemotherapy for experimental subarachnoid dissemination model of brain tumor]. No shinkei geka. Neurological surgery, 1984, Volume: 12, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Glioma; Injections, Intraperitoneal; Meningeal Neoplasms; Methotrexate; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Picibanil; Rats; Rats, Inbred Strains	1984
Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. Federation proceedings, 1984, Volume: 43, Issue:2 Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Enzymes; Glioma; Methotrexate; Rats; Tomography, X-Ray Computed; Water-Electrolyte Balance	1984
Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption. Annals of internal medicine, 1981, Volume: 94, Issue:4 pt 1 Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Glioma; Humans; Mannitol; Methotrexate; Tomography, X-Ray Computed	1981
[Experience with high-dose methotrexate therapy for malignant solid tumors]. Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:2 Topics: Adolescent; Adult; Brain Neoplasms; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Glioma; Humans; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Pons	1982
[Results of combined modality treatment of malignant gliomas. Comparison of postoperative irradiation, chemotherapy, and combined radio-polychemotherapy (author's transl)]. Der Nervenarzt, 1981, Volume: 52, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Drug Therapy, Combination; Female; Glioma; Humans; Lomustine; Male; Methotrexate; Middle Aged; Procarbazine; Vincristine	1981
Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix. Cancer research, 1994, Apr-01, Volume: 54, Issue:7 Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Delayed-Action Preparations; Dextrans; Diffusion; Glioma; Gliosarcoma; Humans; Methotrexate; Rats; Tumor Cells, Cultured	1994
Tissue distribution of methotrexate following administration as a solution and as a magnetic microsphere conjugate in rats bearing brain tumors. Journal of neuro-oncology, 1995, Volume: 24, Issue:2 Topics: Animals; Brain Neoplasms; Disease Models, Animal; Drug Delivery Systems; Evaluation Studies as Topic; Glioma; Magnetics; Male; Methotrexate; Microspheres; Rats; Rats, Inbred F344; Solutions; Tissue Distribution	1995
[Correlation of serial MRI and histological findings following intra-tumor local chemotherapy for malignant brain tumor]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:2 Topics: Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Cobalt Radioisotopes; Doxorubicin; Drug Administration Schedule; Female; Glioblastoma; Glioma; Humans; Injections, Intralesional; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Necrosis	1994
Proliferation, migration and invasion of human glioma cells exposed to antifolate drugs. International journal of cancer, 1993, Apr-22, Volume: 54, Issue:1 Topics: Animals; Brain; Cell Division; Cell Movement; Cytotoxins; Folic Acid Antagonists; Glioma; Humans; In Vitro Techniques; Methotrexate; Organoids; Rats; Trimetrexate; Tumor Cells, Cultured	1993
Leukotriene E4 selectively increase the delivery of methotrexate to the C6 gliomas in rats. Journal of neuro-oncology, 1995, Volume: 25, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Autoradiography; Blood Gas Analysis; Brain Neoplasms; Carotid Arteries; Female; Fluorouracil; Glioma; Infusions, Intra-Arterial; Leukotriene E4; Methotrexate; Neoplasm Transplantation; Permeability; Rats; Rats, Wistar; Tumor Cells, Cultured	1995
In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats. Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Brain Chemistry; Brain Neoplasms; Glioma; Male; Methotrexate; Microdialysis; Neoplasm Transplantation; Rats; Rats, Inbred F344; Tumor Cells, Cultured	1996
[Histopathological and autoradiographical studies of experimental brain tumors after continuous local chemotherapy--acute stage in rat models]. Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autoradiography; Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Glioma; Infusion Pumps; Male; Methotrexate; Rats; Rats, Inbred F344	1997
Chemotherapy of human malignant glioma: prevention of efficacy by dexamethasone? Neurology, 1997, Volume: 48, Issue:6 Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Cell Cycle; Cell Survival; Cytarabine; Dexamethasone; Doxorubicin; Drug Interactions; Glioma; Humans; Methotrexate; Nimustine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Teniposide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vincristine	1997
Effects of photodynamic therapy combined with methotrexate on C6 rat glioma cells: a preliminary study. Journal of clinical laser medicine & surgery, 1996, Volume: 14, Issue:2 Topics: Animals; Antineoplastic Agents; Dihematoporphyrin Ether; Drug Resistance, Neoplasm; Drug Therapy, Combination; Evaluation Studies as Topic; Glioma; Methotrexate; Photochemotherapy; Photosensitizing Agents; Rats; Rats, Inbred Strains; Time Factors; Tumor Cells, Cultured	1996
Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. Journal of neuro-oncology, 1998, Volume: 36, Issue:1 Topics: Animals; Brain Neoplasms; Cell Survival; Cisplatin; Colorimetry; Female; Glioma; Leukotriene C4; Male; Methotrexate; Premedication; Rats; Rats, Sprague-Dawley; Survival Analysis; Tetrazolium Salts; Thiazoles	1998
Pharmacokinetics of intra-arterially administered pirarubicin in plasma and cerebrospinal fluid of patients with glioma. Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:3 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Doxorubicin; Female; Glioma; Humans; Infusions, Intra-Arterial; Methotrexate; Peplomycin; Vindesine	1998
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. Journal of the National Cancer Institute, 1999, Jul-21, Volume: 91, Issue:14 Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured	1999
Pharmacokinetics of methotrexate in the extracellular fluid of brain C6-glioma after intravenous infusion in rats. Pharmaceutical research, 1999, Volume: 16, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Capillary Permeability; Computer Simulation; Extracellular Space; Glioma; Infusions, Intravenous; Male; Methotrexate; Microdialysis; Neoplasm Transplantation; Rats; Rats, Wistar; Tissue Distribution; Tumor Cells, Cultured	1999
The effect of anticonvulsant drugs on blood levels of methotrexate. Journal of neuro-oncology, 2000, Volume: 48, Issue:3 Topics: Adult; Anticonvulsants; Biological Availability; Brain Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Glioma; Humans; Leucovorin; Methotrexate	2000
Medroxyprogesterone acetate alone or synergistic with chemotherapy suppresses colony formation and DNA synthesis in C6 glioma in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2001, Volume: 19, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Death; Cell Division; Cisplatin; DNA; Drug Synergism; Glioma; Humans; Medroxyprogesterone; Methotrexate; Microscopy, Electron; Nucleic Acid Synthesis Inhibitors; Procarbazine; Progesterone Congeners; Tumor Cells, Cultured; Tumor Stem Cell Assay	2001
[Regional chemotherapy of malignant brain tumors with endolumbar methotrexate injection]. Zentralblatt fur Neurochirurgie, 1976, Volume: 37, Issue:3 Topics: Brain Neoplasms; Choriocarcinoma; Female; Glioma; Humans; Injections; Lumbosacral Region; Methotrexate; Palliative Care; Pregnancy; Sarcoma	1976
Identification of dihydrofolate reductase in human central-nervous-system tumours. Lancet (London, England), 1978, Jan-28, Volume: 1, Issue:8057 Topics: Adenocarcinoma; Astrocytoma; Brain; Brain Chemistry; Brain Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Female; Glioblastoma; Glioma; Humans; Meningeal Neoplasms; Meningioma; Methotrexate; Neoplasm Metastasis; Tetrahydrofolate Dehydrogenase	1978
[Combined therapy of brain tumors (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Jan-17, Volume: 67, Issue:3 Topics: Adrenal Cortex Hormones; Brain Edema; Brain Neoplasms; Brain Stem; Craniopharyngioma; Ependymoma; Glioblastoma; Glioma; Humans; Injections, Spinal; Medulloblastoma; Methotrexate; Neoplasm Metastasis; Nitrosourea Compounds; Pinealoma; Protons	1978
Brain tumors in children. Pediatric annals, 1978, Volume: 7, Issue:8 Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Diagnosis, Differential; Ependymoma; Female; Glioblastoma; Glioma; Humans; Lomustine; Male; Medulloblastoma; Methotrexate; Neoplasm Recurrence, Local; Procarbazine; Radiotherapy Dosage; Vincristine	1978
Combination chemotherapy of malignant glioma. Effect of postoperative treatment with CCNU, vincristine, amethopterine and procarbazine. European journal of cancer, 1978, Volume: 14, Issue:11 Topics: Adolescent; Adult; Aged; Brain Neoplasms; Drug Therapy, Combination; Glioma; Humans; Lomustine; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Nitrosourea Compounds; Peripheral Nervous System Diseases; Postoperative Period; Procarbazine; Vincristine	1978
High-dose methotrexate with citrovorum factor rescue for the treatment of central nervous system tumors in children. Cancer treatment reports, 1977, Volume: 61, Issue:4 Topics: Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; Female; Glioma; Humans; Leucovorin; Male; Medulloblastoma; Methotrexate; Neoplasm Recurrence, Local; Pons	1977
High-dose methotrexate in malignant gliomas. Cancer treatment reports, 1977, Volume: 61, Issue:4 Topics: Adolescent; Adult; Brain Neoplasms; Drug Therapy, Combination; Female; Glioma; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Nervous System	1977
A method of correcting for linear drift in computed tomography brain scans. Journal of computer assisted tomography, 1979, Volume: 3, Issue:2 Topics: Adolescent; Brain; Brain Diseases; Cerebellar Neoplasms; Cerebral Ventriculography; Cerebrospinal Fluid; Electronics, Medical; Glioma; Humans; Methotrexate; Tomography, X-Ray Computed	1979
[Risk of a second malignant neoplasm after successful treatment of a malignant tumour in children (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1979, Jul-06, Volume: 104, Issue:27 Topics: Adolescent; Age Factors; Child; Child, Preschool; Craniopharyngioma; Diagnostic Errors; Female; Fibroma; Glioma; Humans; Iatrogenic Disease; Infant; Leukemia, Radiation-Induced; Lomustine; Male; Methotrexate; Neoplasms, Radiation-Induced; Rhabdomyosarcoma; Risk	1979
Combination chemotherapy for extracranial metastases of a primary malignant cerebral neoplasm. Cancer treatment reports, 1979, Volume: 63, Issue:8 Topics: Adult; Antineoplastic Agents; Bone Neoplasms; Brain Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Glioma; Humans; Lomustine; Lung Neoplasms; Male; Methotrexate	1979
Drug-induced differentiation of a rat glioma in vitro: II. the expression of S-100, a glial specific protein and steroid sulfatase. Brain research, 1978, Mar-31, Volume: 143, Issue:3 Topics: Animals; Bromodeoxyuridine; Cell Division; Cells, Cultured; DNA Replication; Glioma; In Vitro Techniques; Methotrexate; Neoplasm Proteins; Rats; Steroids; Sulfatases; Time Factors	1978
Therapy of an experimental glioma with systemic or intraneoplastic methotrexate or radiation. Journal of neurosurgery, 1977, Volume: 46, Issue:2 Topics: Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glioma; Injections; Methotrexate; Mice; Neoplasms, Experimental	1977
[Local and intravenous cytostatic therapy after surgery of malignant brain tumors]. Wiener medizinische Wochenschrift (1946), 1977, Volume: 127, Issue:2 Topics: Administration, Topical; Brain Neoplasms; Cyclophosphamide; Female; Fluorouracil; Glioma; Humans; Injections, Intravenous; Male; Methotrexate; Vincristine	1977
Neurosurgical aspects of supratentorial malignant gliomas. Proceedings of the Royal Society of Medicine, 1976, Volume: 69, Issue:1 Topics: Biopsy; Brain Neoplasms; Carmustine; Craniotomy; Glioma; Methotrexate	1976
Chemotherapy of brain tumors. Advances in neurology, 1976, Volume: 15 Topics: Brain Neoplasms; Carmustine; Drug Combinations; Glioma; Humans; Lomustine; Methotrexate; Podophyllotoxin; Vincristine	1976
Chemotherapy of primary malignant brain tumors in children. Cancer, 1975, Volume: 35, Issue:3 suppl Topics: Antineoplastic Agents; Brain Neoplasms; Brain Stem; Carmustine; Child; Ependymoma; Glioma; Humans; Medulloblastoma; Methotrexate; Nitrosourea Compounds; Podophyllotoxin; Procarbazine; Vincristine	1975
Editorial: Brain tumor. Current status of treatment and its complications. Archives of neurology, 1975, Volume: 32, Issue:12 Topics: Brain Neoplasms; Carcinoma; Carmustine; Glioma; Humans; Meninges; Methotrexate; Neoplasm Metastasis; Nitrosourea Compounds	1975
Clinical outcome in aggressively treated meningeal gliomatosis. Neurology, 1992, Volume: 42, Issue:1 Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Cerebrospinal Fluid; Combined Modality Therapy; Female; Glioblastoma; Glioma; Humans; Male; Meninges; Methotrexate; Middle Aged; Neuroglia; Oligodendroglioma; Survival Analysis	1992
Neoadjuvant chemotherapy in the treatment of recurrent glioblastomas (GBM). Italian journal of neurological sciences, 1992, Volume: 13, Issue:7 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Fluorouracil; Glioma; Humans; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Reoperation	1992
[Cyst formation following local chemotherapy of malignant brain tumor: a clinicopathological study of two cases]. No shinkei geka. Neurological surgery, 1992, Volume: 20, Issue:11 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Cysts; Doxorubicin; Glioma; Humans; Infusion Pumps, Implantable; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Radiotherapy Dosage; Tomography, X-Ray Computed	1992
Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review. Journal of neuro-oncology, 1992, Volume: 12, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Follow-Up Studies; Glioma; Humans; Mannitol; Methotrexate; Necrosis; Procarbazine; Retrospective Studies; Technetium Tc 99m Pentetate; Tomography, X-Ray Computed	1992
Cerebrovascular effects and tumor kinetics after a single intratumoral injection of human recombinant interleukin-2 alone or in combination with intravenous chemotherapy in a rat model of glioma. Neurosurgery, 1992, Volume: 31, Issue:1 Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Combined Modality Therapy; Doxorubicin; Glioma; Humans; Injections, Intralesional; Interleukin-2; Methotrexate; Necrosis; Neoplasm Transplantation; Rats; Rats, Inbred F344; Recombinant Proteins; Vincristine	1992
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump. The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3 Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; Methotrexate; Probenecid; Prostaglandins A; Rats; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil	1991
[Intra-arterial infusion of high dose methotrexate therapy in recurrent gliomas]. Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:8 Pt 1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Evaluation; Female; Glioma; Humans; Infusions, Intra-Arterial; Leucovorin; Male; Mannitol; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction	1990
Interstitial chemotherapy of experimental gliomas. Cancer treatment reviews, 1990, Volume: 17, Issue:2-3 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Drug Carriers; Drug Screening Assays, Antitumor; Glioma; Humans; Injections, Intralesional; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Phospholipid Ethers; Phosphorylcholine; Polyesters; Rats; Rats, Inbred Strains	1990
Combined intraarterial and systemic chemotherapy for intracerebral tumors. Neurosurgery, 1987, Volume: 21, Issue:2 Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Carmustine; Cisplatin; Glioma; Glycerol; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Methotrexate; Middle Aged; Procarbazine; Teniposide; Vincristine	1987
[Meningeal gliomatosis--clinical features and results of treatment]. Gan no rinsho. Japan journal of cancer clinics, 1989, Volume: 35, Issue:11 Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brain Neoplasms; Child; Cytarabine; Female; Glioma; Humans; Incidence; Male; Meningeal Neoplasms; Methotrexate; Middle Aged	1989
[Antitumor efficacy of FK 973 on malignant glioma cells]. Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:7 Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Doxorubicin; Drug Screening Assays, Antitumor; Glioma; Methotrexate; Mice; Mice, Inbred C3H; Nimustine; Oxazines	1989
Liposomes coupled with monoclonal antibodies against glioma-associated antigen for targeting chemotherapy of glioma. Journal of neurosurgery, 1989, Volume: 71, Issue:3 Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Brain Neoplasms; Drug Carriers; Glioma; Humans; Liposomes; Methotrexate; Tumor Cells, Cultured	1989
New xenograft model for assessing experimental therapy of central nervous system tumors: human glioblastoma in the intrathecal compartment of the nude mouse. Neurosurgery, 1988, Volume: 22, Issue:5 Topics: Animals; Carmustine; Cell Line; Disease Models, Animal; Drug Screening Assays, Antitumor; Glioma; Humans; Injections, Intraperitoneal; Injections, Spinal; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms, Nerve Tissue; Spinal Cord; Time Factors; Transplantation, Heterologous	1988
Maculopathy associated with combination chemotherapy and osmotic opening of the blood-brain barrier. American journal of ophthalmology, 1986, Nov-15, Volume: 102, Issue:5 Topics: Adolescent; Adult; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Macula Lutea; Mannitol; Methotrexate; Middle Aged; Osmosis; Retinal Diseases	1986
[Reversible opening of the blood-brain barrier in the chemotherapy of malignant gliomas]. Wiener klinische Wochenschrift, 1987, May-29, Volume: 99, Issue:11 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Glioma; Humans; Infusions, Intra-Arterial; Mannitol; Methotrexate	1987
[Effects of the use of cranial radiotherapy. Findings obtained by computerized axial tomography and intellectual function tests]. Anales espanoles de pediatria, 1988, Volume: 28, Issue:5 Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed	1988
The intraneoplastic chemotherapy in a rat brain tumour model utilizing methotrexate-polymethylmethacrylate-pellets. Acta neurochirurgica, 1987, Volume: 87, Issue:1-2 Topics: Animals; Brain Neoplasms; Drug Carriers; Drug Implants; Ethylnitrosourea; Glioma; Methotrexate; Methylmethacrylates; Rats; Stereotaxic Techniques	1987
Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a quantitative autoradiographic study. Cancer research, 1988, Feb-01, Volume: 48, Issue:3 Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Carotid Arteries; Glioma; Injections, Intra-Arterial; Male; Methotrexate; Rats; Tissue Distribution	1988
Transient cerebral dysfunction secondary to high-dose methotrexate. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Brain Diseases; Electroencephalography; Female; Glioma; Hodgkin Disease; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Paresis; Seizures; Syndrome	1986
Late multifocal gliomas in adolescents previously treated for acute lymphoblastic leukemia. Cancer, 1987, Oct-01, Volume: 60, Issue:7 Topics: Adolescent; Brain Neoplasms; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Tomography, X-Ray Computed; Vincristine	1987
[Local use of cytostatic drugs following removal of glioblastomas]. Wiener klinische Wochenschrift, 1987, Oct-09, Volume: 99, Issue:19 Topics: Brain Neoplasms; Combined Modality Therapy; Follow-Up Studies; Glioma; Humans; Methotrexate	1987
Synergistic effect of methotrexate and radiation on gliosarcoma in tissue culture and in rats. Neurosurgery, 1986, Volume: 18, Issue:5 Topics: Animals; Brain Neoplasms; Cell Line; Combined Modality Therapy; Glioma; Methotrexate; Neoplasm Transplantation; Rats	1986
The origin and rate of formation of cerebrospinal fluid gamma globulin in subacute sclerosing leukoencephalitis. Transactions of the American Neurological Association, 1967, Volume: 92 Topics: Antibody Formation; Brain Neoplasms; gamma-Globulins; Glioma; Humans; Iodine Isotopes; Iodoproteins; Methotrexate; Subacute Sclerosing Panencephalitis	1967
[Experience with non-surgical treatment of brain tumors at the authors' department]. No to shinkei = Brain and nerve, 1967, Volume: 19, Issue:4 Topics: Adenoma, Chromophobe; Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; Cobalt Isotopes; Female; Floxuridine; Folic Acid; Glioma; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Radioisotope Teletherapy	1967
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine). Journal of neurosurgery, 1968, Volume: 28, Issue:6 Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; Follow-Up Studies; Glioma; Humans; Meningioma; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Thymidine	1968
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil. Journal of the National Cancer Institute, 1971, Volume: 46, Issue:2 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Evaluation Studies as Topic; Fluorouracil; Glioma; Injections, Intraperitoneal; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Plicamycin; Urea; Vincristine	1971
[Chemotherapy of malignant brain tumors by intermittent and continuous intra-arterial infusion of antitumor agents--clinical study]. No to shinkei = Brain and nerve, 1966, Volume: 18, Issue:11 Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Arteries; Brain Edema; Brain Neoplasms; Cyclophosphamide; Female; Glioblastoma; Glioma; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Mitomycins; Nitrogen Mustard Compounds; Thiotepa	1966
[Vascularization of cerebral tumors. Study by selective peroperative angiography]. Neuro-Chirurgie, 1967, Volume: 13, Issue:7 Topics: Astrocytoma; Brain Neoplasms; Cerebral Angiography; Cyclophosphamide; Glioblastoma; Glioma; Humans; Injections, Intra-Arterial; Methotrexate	1967
Faliure to demonstrate desmosterol in spinal fluid of brain tumor patients. Archives of neurology, 1973, Volume: 28, Issue:2 Topics: Animals; Astrocytoma; Brain Neoplasms; Cholesterol; Chromatography, Gas; Culture Techniques; Desmosterol; Glioblastoma; Glioma; Humans; Methotrexate; Oligodendroglioma; Rats; Sterols; Triparanol	1973
[Combined cytostatic treatment of malignant brain tumors (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1974, Nov-08, Volume: 116, Issue:45 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Glioblastoma; Glioma; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Monomethylhydrazine; Neoplasm Metastasis; Vinblastine	1974
Uptake of tritiated methotrexate by mouse brain tumors after intravenous or intrathecal administration. Journal of neurosurgery, 1974, Volume: 40, Issue:6 Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Squamous Cell; Glioma; Injections, Intravenous; Injections, Spinal; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma; Skull Neoplasms; Tritium	1974
Pontine glioma. High-dose methotrexate and leucovorin rescue. JAMA, 1974, Nov-25, Volume: 230, Issue:8 Topics: Administration, Oral; Brain Neoplasms; Calcium; Child; Drug Evaluation; Glioma; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Pons; Remission, Spontaneous	1974
Drug-induced differentiation of a rat glioma in vitro. Cancer research, 1972, Volume: 32, Issue:7 Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Line; Clone Cells; Dactinomycin; Desmosomes; Glioma; Glycogen; In Vitro Techniques; Methotrexate; Microscopy, Electron; Microscopy, Phase-Contrast; Rats; Stimulation, Chemical	1972
Necrotizing encephalopathy following intraventricular instillation of methotrexate. Archives of neurology, 1973, Volume: 28, Issue:2 Topics: Adolescent; Brain; Brain Diseases; Brain Neoplasms; Carmustine; Cerebellar Neoplasms; Cerebral Ventricle Neoplasms; Cerebral Ventricles; Child; Female; Glioma; Humans; Injections, Spinal; Leukemia; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Methotrexate; Middle Aged	1973
Peritoneal gliomatosis produced by ovarian teratomas. Obstetrics and gynecology, 1974, Volume: 43, Issue:6 Topics: Adult; Chlorambucil; Dactinomycin; Fallopian Tubes; Female; Glioma; Humans; Hysterectomy; Methotrexate; Middle Aged; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Peritoneal Neoplasms; Teratoma; Vinblastine	1974
Regional chemotherapeutic perfusion and infusion of brain and face tumors. Annals of surgery, 1967, Volume: 166, Issue:2 Topics: Adenocarcinoma; Ameloblastoma; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Ethylenediamines; Facial Neoplasms; Fibrosarcoma; Glioma; Humans; Infusions, Parenteral; Mechlorethamine; Melanoma; Melphalan; Meningioma; Methotrexate; Osteosarcoma; Perfusion; Quinones; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Thiotepa	1967
The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors. Cancer research, 1972, Volume: 32, Issue:10 Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Bone Marrow; Brain; Brain Neoplasms; Carbon Isotopes; Carmustine; Cyclohexanes; Cytarabine; Deoxyuridine; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Ependymoma; Glioma; Lymph Nodes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Thymidine; Tritium	1972
Surgery and chemotherapy of brain tumors in children. Progress in experimental tumor research, 1972, Volume: 17 Topics: Astrocytoma; Brain Neoplasms; Child; Craniopharyngioma; Ependymoma; Glioma; Humans; Medulloblastoma; Methotrexate	1972
The uptake of tritiated methotrexate by an experimental glioma. Cancer research, 1971, Volume: 31, Issue:11 Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain Neoplasms; Ependymoma; Female; Glioma; Methotrexate; Mice; Neoplasms, Experimental; Tritium	1971
A new approach to the treatment of inoperable brain tumors. The Medical annals of the District of Columbia, 1965, Volume: 34, Issue:10 Topics: Adult; Brain Neoplasms; Child; Glioma; Humans; Methotrexate; Perfusion	1965
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate. Cancer research, 1970, Volume: 30, Issue:9 Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Glioma; Injections; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Statistics as Topic; Urea	1970