Page last updated: 2024-08-25

methotrexate and Genetic Predisposition

methotrexate has been researched along with Genetic Predisposition in 100 studies

Research

Studies (100)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.00)	18.2507
2000's	44 (44.00)	29.6817
2010's	44 (44.00)	24.3611
2020's	11 (11.00)	2.80

Authors

Authors	Studies
Coêlho, MC; de Oliveira, NFP; de Souza, BF; Persuhn, DC; Valença, AMG; Viana Filho, JMC	1
Chen, M; Chen, W; Chen, X; Kuang, Y; Liu, P; Lu, Y; Lv, C; Mao, M; Yan, K; Zhu, W	1
Chen, L; Deng, J; Niu, PG; Shi, DH; Xue, H; Zeng, FX	1
Jabbour, EJ; Kadia, TM; Kantarjian, HM; Rausch, CR	1
Bakirov, A; Danilko, K; Karimov, D; Malievsky, V; Nazarova, L; Viktorova, T	1
-Maniglia, JV; Biselli-Chicote, PM; Goloni-Bertollo, EM; Maniglia, MP; Oliveira-Cucolo, JG; Pavarino, ÉC; Rodrigues-Fleming, GH; Russo, A	1
Chang, X; Guo, Y; Hu, R; Hui, W; Su, L; Sun, W; Zhang, Y; Zhao, H	1
Aladle, DA; El Marghany, AB; El Menshawy, N; Sarhan, MM	1
Hu, Z; Jenkins, B; Koulman, A; Lenaerts, AS; Liang, TJ; Morell, CM; Park, SB; Tilson, SG; Vallier, L	1
Cai, M; Chang, Y; Chen, M; Ding, X; Jin, L; Li, X; Lu, Y; Meng, Z; Qian, D; Wu, J; Wu, M; Yan, K; Zhang, Q; Zhang, X; Zhang, Y; Zheng, X	1
Bai, H; Liu, WH; Mao, DF; Ren, LW; Wang, ZH; Wu, T; Xue, F; Yu, LL	1
Roszkiewicz, J; Smolewska, E	1
Li, XL; Liu, YW; Nie, XL; Wang, SZ; Wang, XL; Yu, XT; Zhao, LB; Zhu, C	1
Ando, K; Carreras, J; Hiraiwa, S; Ikoma, H; Kondo, Y; Miura, I; Miyaoka, M; Nakamura, N; Roncador, G; Sato, S; Shiraiwa, S; Suzuki, Y; Tomita, S; Yukie Kikuti, Y	1
Gafter-Gvili, A; Klein, A; Polliack, A	1
Beck, LA; Bieber, T; Irvine, AD; Kabashima, K; Weidinger, S	1
Bašić, J; Cvetković, M; Cvetković, T; Despotović, M; Jevtović-Stoimenov, T; Lazarević, D; Milošević, V; Pavlović, D; Sušić, G; Vojinović, J	1
Aceves-Aceves, MA; Dávalos-Rodríguez, IP; Díaz-Pérez, AL; Enríquez-Barajas, CM; Gámez-Nava, JI; González-López, L; Hernández-Preciado, MR; Morán-Moguel, MC; Salazar-Páramo, M; Silva-Castro, DE; Valdovinos-Maravilla, JP	1
Barroilhet, L; Buza, N; Hui, P; McGregor, SM; Zheng, X	1
Chang, YL; Fang, X; Han, L; Huang, Q; Jin, L; Li, XY; Qian, DF; Wu, MS; Xu, JH; Xu, QH; Yan, KX; Yawalkar, N; Zhang, Q; Zhang, XJ; Zhang, YJ; Zhang, ZH; Zheng, ZZ	1
Bezuidenhout, E; Bosch, FJ; Buchel, OC; de K Grundling, H; de Vries, CS; Fevery, J; Janse van Rensburg, J; Middlecote, BD; van Zyl, JH	1
Goulielmos, GΝ; Kalmanti, M; Karathanasis, NV; Stiakaki, E	1
Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z	1
Bhojwani, D; Cheng, C; Evans, WE; Howard, SC; Inaba, H; Jeha, S; Khan, RB; Krull, KR; Metzger, ML; Panetta, JC; Pei, D; Pui, CH; Reddick, WE; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sabin, ND; Sandlund, JT; Yang, JJ	1
Asklid, A; Fornander, T; Söderlund Leifler, K; Stenmark Askmalm, M	1
Ma, CX; Sun, YH; Wang, HY	1
Askling, J; Frisell, T; Saevarsdottir, S	1
Cole, PD	1
Battafarano, DF; del Rincón, I; Doria, M; Escalante, A; Haas, RW; Restrepo, JF	1
Fujiwara, M; Fujiwara, T; Kawai, A; Numoto, K; Ogura, K; Suzuki, S; Yonemoto, T; Yoshida, A	1
Bogunia-Kubik, K; Iwaszko, M; Jeka, S; Kolossa, K; Świerkot, J; Wiland, P	1
Bing, X; Ferguson, PJ; Gopalakrishna, DB; Rao, AP	1
Kaku, H; Qu, J; Shozu, M; Usui, H	1
Antonin Kubena, A; Barvik, I; Bradna, P; Dosedel, M; Duintjer Tebbens, J; Nekvindova, J; Pavek, P; Soukup, T; Tacheci, I; Vlcek, J	1
Abutiban, F; Aftab, B; Al-Awadhi, A; Al-Herz, A; Al-Kandari, W; Al-Saber, A; Alenizi, A; Ali, Y; Bartella, Y; Fazal, A; Ghanem, A; Haider, N; Hamed, S; Hasan, E; Hussain, M; Khadrawy, A; Mazloum, G; Mokaddem, K; Saleh, K; Zaman, A	1
Blonquist, TM; Cole, PD; Finkelstein, Y; Neuberg, DS; Sallan, SE; Silverman, LB; Stevenson, KE; Vijayanathan, V; Vrooman, LM	1
Kalthoum, T; Kamel, H; Marwa, OS; Wajih, K	1
Berg, L; Catrina, AI; Diaz-Gallo, LM; Folkersen, L; Hensvold, AH; Klareskog, L; Padyukov, L; Shchetynsky, K	1
Armstrong, DJ; Bruce, IN; Hider, SL; Mack, LF; Shadforth, M; Thomson, W	1
Cheng, C; Downing, JR; Evans, WE; French, D; Mullighan, CG; Pui, CH; Raimondi, SC; Relling, MV; Yang, W	1
Aneja, R; Arya, V; B K, T; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; Kumar, A; Kumar, U; Marwaha, V; Shankar, S; Sharma, S	1
Eden, T; Hill, F; Hussain, A; Mitchell, C; Richards, S; Simpson, J; Taylor, GM; Wade, R	1
Cronstein, BN; Fisher, MC	1
Aono, H; Ishihara, K; Katsuta, O; Takai, M; Tsuji, F; Yoshimi, M	1
Braus, NA; Elliott, DE	1
Furuya, T; Hara, M; Inoue, E; Inoue, S; Kamatani, N; Kotake, S; Momohara, S; Sekita, C; Taniguchi, A; Urano, T; Urano, W; Yamanaka, H	1
Kim, YI	1
Al-Refai, EA; Amjad D, AN; Khassawneh, MY; Sadiq, MF	1
Carroll, WL; Devidas, M; Downing, J; Evans, WE; French, D; Hunger, SP; Neale, G; Pui, CH; Raimondi, SC; Relling, MV; Treviño, LR; Willman, C; Yang, W	1
Chan, D; Cheng, C; Evans, WE; Giacomini, KM; Panetta, JC; Pei, D; Pui, CH; Relling, MV; Shimasaki, N; Sparreboom, A; Treviño, LR; Yang, W	1
Abdulghaffar, EE; Abou El Asrar, M; Adly, AA; El-Bostany, EA; El-Ghouroury, EA; Tantawy, AA	1
Dhall, G; Ettinger, LJ; Lastra, C; Mahadeo, KM; Panigrahy, A	1
Dolzan, V; Faganel Kotnik, B; Grabnar, I; Jazbec, J	1
Abeloff, MD; Albain, KS; Ambrosone, CB; Barlow, WE; Choi, JY; Davis, W; Hayes, DF; Hortobagyi, GN; Hutchins, LF; Livingston, RB; Lyss, AP; Martino, S; Osborne, CK; Rae, JM; Ravdin, PM; Yao, S; Yeh, IT; Zhao, H	1
McLeod, H; Ranganathan, P	1
Börzsönyi, B; Csanád, M; Demendi, C; Joó, JG; Nagy, ZB; Rigó, J; Tóth, K	1
Borges-Costa, J; Marques-Gomes, M; Pacheco, D; Pereira, F	1
Ellison, DW; Frobisher, C; Hawkins, MM; Lancashire, ER; Little, MP; Reulen, RC; Stiller, CA; Stovall, M; Sugden, E; Taylor, AJ; Winter, DL	1
O'Rielly, DD; Rahman, P	1
Mühl, H; Pfeilschifter, J	1
Charalampidou, S; Chatzimeletiou, K; Goulis, DG; Kantartzi, P; Oikonomou, L; Panidis, D; Papadimas, I; Sioga, A; Tarlatzis, BC; Zournatzi, V	1
Ali, FR; Barton, A; Bowes, J; Griffiths, CE; Hébert, HL; Warren, RB	1
Barclay, ML; Roberts, RL	1
Bunjevacki, V; Damjanov, N; Damnjanovic, T; Jekic, B; Kovacevic, L; Krajinovic, M; Lukovic, L; Maksimovic, N; Milasin, J; Milic, V; Novakovic, I; Popovic, B; Radunovic, G	1
Efrati, E; Elkin, H; Krivoy, N; Nahum, S	1
Furukawa, H; Oka, S; Shimada, K; Tohma, S; Tsuchiya, N	1
Kordek, R; Kusinska, R; Majsterek, I; Przybylowska-Sygut, K; Stanczyk, M	1
Assaloni, R; Di Poi, E; Fabris, M; Ferraccioli, G; Sinigaglia, L; Tolusso, B	1
Pender, MP; Wolfe, NP	1
Quismorio, FP; Torralba, KD	1
Bardy, P; Doherty, K; Grigg, A; Heatley, S; Hughes, T; Mullighan, C; Schwarer, A; Szabo, F; Szer, J; Tait, B; To, B	1
Ho, GT; Lees, C; Satsangi, J	1
Bridges, SL; Criswell, LA; Edberg, JC; Kimberly, RP; Lum, RF; Moreland, LW; Seldin, MF; Tiwari, HK; Turner, KN; Wang, J; Woehl, B; Zhu, Y	1
Kallianpur, AR	1
Beasley, TM; Bridges, SL; Criswell, LA; Edberg, JC; Hughes, LB; Kimberly, RP; Moreland, LW; Seldin, MF	1
Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H	1
Aplenc, R; Debeljak, M; Dolzan, V; Jazbec, J; Kitanovski, L	1
Ahmad, T; Barnardo, MC; Cummings, JR; Herrlinger, KR; Jewell, DP; Schwab, M	1
Athreya, BH; Cuttica, R; Esteves Hilário, MO; Feitosa de Oliveira, SK; Foeldvari, I; Garay, SM; Garcia-Consuegra, J; Harper, J; Higgins, GC; Laxer, R; Lepore, L; Lindsley, C; Machado, C; Martini, G; Moore, TL; Nelson, AM; Peserico, A; Punaro, MG; Silva, CA; Uziel, Y; Van Suijlekom-Smit, LW; Woo, P; Zulian, F	1
Kosaki, K; Mori, T; Samejima, H; Sato, R; Shimada, H; Shimasaki, N; Takahashi, T; Tanigawara, Y; Torii, C; Yahagi, N; Yoshihara, H	1
Czerny, B; Dabrowska-Zamojcin, E; Gawrońska-Szklarz, B; Górnik, W; Herczyńska, M; Pawlik, A; Poziomkowska, I	1
Chandra, J; Choudhary, SR; Kumar, A; Naithani, R; Sharma, S	1
Hayakawa, A; Imanishi, H; Matsuo, M; Moriya, Y; Nakamura, T; Noro, Y; Okamura, N; Okumura, K; Sakaeda, T; Takeshima, Y; Yagi, M	1
Glantz, M; Przekop, AA; Przekop, PR; Tulgan, H	1
Azzarello, A; Cloos, J; de Lange, D; Giovannetti, E; Peters, GJ; Supriyadi, E; Ugrasena, DG; Veerman, AJ; Vroling, L	1
Aithal, GP	1
Kinukawa, N; Koga, H; Naito, S; Tsunoda, T; Yamamoto, K; Yokomizo, A	1
Gupta, N; Jhamb, R; Kumar, S; Mishra, D	1
Chen, L; Fan, Y; Fu, L; Guo, XJ; Lang, RG; Sun, YL	1
Bomgaars, L; Bottomley, S; Brouwers, P; Dreyer, Z; Jain, N; Krull, KR; Mahoney, D; Okcu, MF; Zhang, L	1
Ranganathan, P	1
Brasington, R; Culverhouse, R; Eisen, S; Joseph, A; Marsh, S; McLeod, HL; Mody, A; Ranganathan, P; Reddy, V; Scott-Horton, TJ	1
Dervieux, T	1
Gandhi, MK; Green, M; Griffiths, L; Hall, S; Nourse, J; Tran, H	1
Ashley, S; Kuan, A; Kulkarni, S; Mehta, J; Mitchell, P; Powles, R; Powles, T; Saso, R; Swansbury, GJ; Treleaven, J	1
Aranoff, GS; Feldstein, NA; Garvin, JH; Hays, AP; Levine, LS; Oberfield, SE; Silfen, ME; Starkman, HS; Wong, B	1
Lochmüller, H; Müller-Felber, W; Pongratz, D; Reilich, P; Schlotter, B; Walter, MC	1
Blom, HJ; de Boo, TM; Giesendorf, BA; Haagsma, CJ; Huizinga, TW; Laan, RF; van de Putte, LB; van Ede, AE	1
Akama, H; Kamatani, N; Kitamura, Y; Matsuda, Y; Nakajima, H; Tanaka, E; Taniguchi, A; Urano, W; Yamanaka, H	1
Horie, H; Kinugawa, N; Kudoh, F; Miyamoto, S; Okimoto, Y; Oto, S	1

Reviews

17 review(s) available for methotrexate and Genetic Predisposition

Article	Year
In the Pursuit of Methotrexate Treatment Response Biomarker in Juvenile Idiopathic Arthritis-Are We Getting Closer to Personalised Medicine? Current rheumatology reports, 2017, Volume: 19, Issue:4 Topics: Antirheumatic Agents; Arthritis, Juvenile; Biomarkers; Drug Monitoring; Genetic Predisposition to Disease; Humans; Methotrexate; Precision Medicine; Treatment Outcome	2017
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis. The pharmacogenomics journal, 2018, 05-22, Volume: 18, Issue:3 Topics: Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pediatrics; Polymorphism, Single Nucleotide; Risk Factors	2018
Rheumatoid arthritis and lymphoma: Incidence, pathogenesis, biology, and outcome. Hematological oncology, 2018, Volume: 36, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Incidence; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Risk Factors	2018
Atopic dermatitis. Nature reviews. Disease primers, 2018, 06-21, Volume: 4, Issue:1 Topics: Administration, Topical; Adrenal Cortex Hormones; Azathioprine; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcineurin Inhibitors; Chronic Disease; Dermatitis, Atopic; Filaggrin Proteins; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Intermediate Filament Proteins; Methotrexate; Phosphodiesterase 4 Inhibitors; Quality of Life; Severity of Illness Index; Urticaria	2018
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity. The Journal of rheumatology, 2009, Volume: 36, Issue:3 Topics: Enzyme Inhibitors; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide	2009
Advances in the pathogenesis and treatment of IBD. Clinical immunology (Orlando, Fla.), 2009, Volume: 132, Issue:1 Topics: Adult; Animals; Female; Genetic Predisposition to Disease; Humans; Immunity, Mucosal; Immunosuppressive Agents; Inflammatory Bowel Diseases; Methotrexate; Nematoda	2009
Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future oncology (London, England), 2009, Volume: 5, Issue:4 Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Polymorphism, Single Nucleotide; Risk Factors	2009
Pharmacogenetics of psoriasis. Pharmacogenomics, 2011, Volume: 12, Issue:1 Topics: Acitretin; Adrenal Cortex Hormones; Antibodies, Monoclonal; Cyclosporine; Genetic Predisposition to Disease; Humans; Methotrexate; Pharmacogenetics; Precision Medicine; Psoriasis	2011
Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy. The British journal of dermatology, 2012, Volume: 166, Issue:3 Topics: Antirheumatic Agents; Arthritis, Psoriatic; Biological Products; Dermatologic Agents; Forecasting; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Psoriasis	2012
Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease. Journal of gastroenterology and hepatology, 2012, Volume: 27, Issue:10 Topics: Antibodies, Monoclonal; Azathioprine; Biotransformation; Crohn Disease; Drug Hypersensitivity; Drug Interactions; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Humans; Immunologic Factors; Infliximab; Mercaptopurine; Methotrexate; Patient Selection; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Precision Medicine; Purine-Pyrimidine Metabolism, Inborn Errors; Risk Assessment; Risk Factors; Tumor Necrosis Factor-alpha	2012
Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects. Internal medicine journal, 2002, Volume: 32, Issue:11 Topics: Adjuvants, Immunologic; Autoimmune Diseases; Azathioprine; B-Lymphocytes; Cyclophosphamide; Disease Progression; Genetic Predisposition to Disease; Glatiramer Acetate; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulins, Intravenous; Interferon-beta; Magnetic Resonance Imaging; Methotrexate; Methylprednisolone; Mitoxantrone; Models, Theoretical; Multiple Sclerosis; Peptides	2002
Sarcoid arthritis: a review of clinical features, pathology and therapy. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2003, Volume: 20, Issue:2 Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chronic Disease; Environment; Genetic Predisposition to Disease; Granuloma; Humans; Immunosuppressive Agents; Inflammation; Methotrexate; Sarcoidosis; Tumor Necrosis Factor-alpha	2003
Pharmacogenetics and inflammatory bowel disease: progress and prospects. Inflammatory bowel diseases, 2004, Volume: 10, Issue:2 Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Azathioprine; Drug Therapy, Combination; Female; Forecasting; Genetic Predisposition to Disease; Genotype; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Male; Mercaptopurine; Methotrexate; Pharmacogenetics; Prognosis; Risk Assessment; Treatment Outcome	2004
Genomic screening and complications of hematopoietic stem cell transplantation: has the time come? Bone marrow transplantation, 2005, Volume: 35, Issue:1 Topics: Alleles; Genetic Linkage; Genetic Predisposition to Disease; Genome; Genotype; Graft Survival; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Iron; Liver; Lung Diseases; Mass Screening; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Models, Chemical; Oligonucleotide Array Sequence Analysis; Oxidants; Polymorphism, Genetic; Renal Insufficiency; Risk Factors; Time Factors; Transplantation Conditioning; Treatment Outcome	2005
Pharmacogenomics in rheumatoid arthritis. Methods in molecular biology (Clifton, N.J.), 2008, Volume: 448 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Biotransformation; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Patient Selection; Pharmacogenetics; Phenotype; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha	2008
Immunodeficiency-associated lymphomas. Blood reviews, 2008, Volume: 22, Issue:5 Topics: Epstein-Barr Virus Infections; Genetic Predisposition to Disease; Humans; Immunocompromised Host; Immunologic Deficiency Syndromes; Lymphoma; Methotrexate; Tumor Necrosis Factor-alpha; Virus Latency	2008
[New insights in pathogenesis and therapy of sporadic inclusion body myositis (s-IBM)]. Der Nervenarzt, 2001, Volume: 72, Issue:2 Topics: Aged; Antilymphocyte Serum; Crystallins; Drug Therapy, Combination; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Immunosorbent Techniques; Immunosuppressive Agents; Immunotherapy; Methotrexate; Middle Aged; Myosin Heavy Chains; Myositis, Inclusion Body; NF-kappa B; Physical Therapy Modalities	2001

Trials

7 trial(s) available for methotrexate and Genetic Predisposition

Article	Year
TT genotype of rs10036748 in TNIP1 shows better response to methotrexate in a Chinese population: a prospective cohort study. The British journal of dermatology, 2019, Volume: 181, Issue:4 Topics: Adult; Aged; Asian People; China; Dermatologic Agents; DNA-Binding Proteins; Drug Resistance; Female; Genetic Predisposition to Disease; Genotyping Techniques; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Psoriasis; Severity of Illness Index; Treatment Outcome	2019
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer. Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Cytosine; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Guanine; Humans; Mastectomy, Segmental; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Rad51 Recombinase; Radiotherapy, Adjuvant; Sequence Analysis, DNA; Treatment Outcome	2015
A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia. Pediatric blood & cancer, 2017, Volume: 64, Issue:7 Topics: Adolescent; Antimetabolites, Antineoplastic; Asparaginase; Child; Child, Preschool; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Osteonecrosis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase	2017
Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Breast cancer research and treatment, 2010, Volume: 124, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Methotrexate; Middle Aged; Neutropenia; Odds Ratio; Phenotype; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Southwestern United States; Superoxide Dismutase; Tamoxifen; Time Factors; Treatment Outcome	2010
Genetic risk factors for infection in patients with early rheumatoid arthritis. Genes and immunity, 2004, Volume: 5, Issue:8 Topics: Age Factors; Aged; Arthritis, Rheumatoid; Etanercept; Female; Genetic Predisposition to Disease; Genotype; Humans; Immunoglobulin G; Lymphotoxin-alpha; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, IgG; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha; Urinary Tract Infections	2004
[The influence of IL-6 polymorphism on efficacy of treatment of rheumatoid arthritis patients with methotrexate and prednisone]. Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:3 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Genotype; Glucocorticoids; Humans; Interleukin-6; Joints; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prednisone; Promoter Regions, Genetic; Severity of Illness Index	2005
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients. Arthritis and rheumatism, 2001, Volume: 44, Issue:11 Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hematinics; Humans; Liver; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Severity of Illness Index; Treatment Outcome	2001

Other Studies

76 other study(ies) available for methotrexate and Genetic Predisposition

Article	Year
Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children. Oral diseases, 2023, Volume: 29, Issue:8 Topics: Adolescent; Adult; Child; Child, Preschool; DNA Methylation; Genetic Predisposition to Disease; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Stomatitis; Young Adult	2023
The HLA-Cw06 allele may predict the response to methotrexate (MTX) treatment in Chinese arthritis-free psoriasis patients. Archives of dermatological research, 2023, Volume: 315, Issue:5* Topics: Alleles; Arthritis, Psoriatic; East Asian People; Genetic Predisposition to Disease; HLA-C Antigens; Humans; Methotrexate; Psoriasis	2023
Contribution of genetic polymorphism of methylene tetrahydrofolate reductase on the effect of methotrexate in ectopic pregnancy patients. Journal of clinical laboratory analysis, 2020, Volume: 34, Issue:1 Topics: Adult; Chorionic Gonadotropin; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Pregnancy, Ectopic	2020
Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management. Cancer, 2020, 03-15, Volume: 126, Issue:6 Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Constipation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Monitoring; Fusion Proteins, bcr-abl; Genetic Predisposition to Disease; Humans; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Kidney; Methotrexate; Ophthalmic Solutions; Peripheral Nervous System Diseases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein-Tyrosine Kinases; Vincristine	2020
The relationship of the immune response mediator genes’ polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis Turkish journal of medical sciences, 2020, 06-23, Volume: 50, Issue:4 Topics: Alleles; Antirheumatic Agents; Arthritis, Juvenile; Child; Female; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genotype; Haplotypes; Humans; Immunity, Innate; Immunogenetics; Male; Methotrexate; Polymorphism, Single Nucleotide; Russia; Sex Factors	2020
Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy. Asian Pacific journal of cancer prevention : APJCP, 2020, Jun-01, Volume: 21, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chemoradiotherapy; Cisplatin; Female; Fluorouracil; Follow-Up Studies; Genetic Predisposition to Disease; Glutathione S-Transferase pi; Haplotypes; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Prognosis; Retrospective Studies; Risk Factors; Squamous Cell Carcinoma of Head and Neck	2020
Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma. Clinical lymphoma, myeloma & leukemia, 2021, Volume: 21, Issue:2 Topics: Acute Kidney Injury; Adult; Aged; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Homozygote; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies	2021
Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity. Asian Pacific journal of cancer prevention : APJCP, 2020, Oct-01, Volume: 21, Issue:10 Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant; Liver Function Tests; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate	2020
Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells. Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:6 Topics: Cell Differentiation; Cell Line; CRISPR-Cas Systems; Ethanol; Gene Knockout Techniques; Genetic Predisposition to Disease; Hepatocytes; Humans; Induced Pluripotent Stem Cells; Lipase; Lipid Metabolism; Loss of Function Mutation; Membrane Proteins; Methotrexate; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide; Toxicity Tests, Acute	2021
A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment. Journal of the European Academy of Dermatology and Venereology : JEADV, 2021, Volume: 35, Issue:12 Topics: Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-C Antigens; Humans; Methotrexate; Psoriasis	2021
[A case of acute lymphoblastic leukemia of MTHFR C677T gene positive with methotrexate hypersensitivity was successfully rescued by hemodialysis]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2021, Jun-14, Volume: 42, Issue:6 Topics: Antimetabolites, Antineoplastic; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Dialysis	2021
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients. The American journal of surgical pathology, 2018, Volume: 42, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; Gene Expression Profiling; Genetic Predisposition to Disease; Humans; In Situ Hybridization, Fluorescence; Lymphocytes, Tumor-Infiltrating; Lymphoma, Large B-Cell, Diffuse; Macrophages; Male; Methotrexate; Middle Aged; Oligonucleotide Array Sequence Analysis; Phenotype; Transcriptome; Tumor Microenvironment	2018
The association of CAT-262C/T polymorphism with catalase activity and treatment response in juvenile idiopathic arthritis. Rheumatology international, 2019, Volume: 39, Issue:3 Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Catalase; Child; Drug Therapy, Combination; Etanercept; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Treatment Outcome; Tumor Necrosis Factor Inhibitors	2019
miRNA-24 Gene Sequence, DHFR -829C-T Genotypes, and Methotrexate Response in Mexican Patients with Rheumatoid Arthritis. Genetic testing and molecular biomarkers, 2019, Volume: 23, Issue:3 Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Mexico; MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase	2019
Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15.4: spectrum of phenotypical presentations simulating hydatidiform moles. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2019, Volume: 32, Issue:8 Topics: Abortion, Missed; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chromosomes, Human, Pair 11; Cyclophosphamide; Dactinomycin; Etoposide; Female; Genetic Loci; Genetic Predisposition to Disease; Humans; Hydatidiform Mole; Male; Methotrexate; Phenotype; Pregnancy; Treatment Outcome; Tyrosine 3-Monooxygenase; Uniparental Disomy; Uterine Neoplasms; Vincristine	2019
Primary sclerosing cholangitis, Crohn's disease and HLA-B27 in black South African women. Acta gastro-enterologica Belgica, 2012, Volume: 75, Issue:4 Topics: Adult; Alkaline Phosphatase; Azathioprine; Back Pain; Black People; Cholagogues and Choleretics; Cholangiopancreatography, Magnetic Resonance; Cholangitis, Sclerosing; Colonoscopy; Crohn Disease; Diarrhea; Female; gamma-Glutamyltransferase; Genetic Predisposition to Disease; HLA-B27 Antigen; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Severity of Illness Index; South Africa; Treatment Outcome; Ursodeoxycholic Acid	2012
The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms. International journal of laboratory hematology, 2014, Volume: 36, Issue:4 Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Greece; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein	2014
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects. Developmental neurobiology, 2014, Volume: 74, Issue:9 Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates	2014
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Mar-20, Volume: 32, Issue:9 Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Leucovorin; Leukoencephalopathies; Logistic Models; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors	2014
ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose methotrexate. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:10 Topics: Adolescent; Adult; Alleles; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leukemia; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Young Adult	2015
Does a family history of RA influence the clinical presentation and treatment response in RA? Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Humans; Male; Medical Record Linkage; Methotrexate; Middle Aged; Prognosis; Registries; Severity of Illness Index; Treatment Failure; Treatment Outcome; Tumor Necrosis Factor-alpha	2016
Does genetic susceptibility increase risk for neurocognitive decline among patients with acute lymphoblastic leukemia? Future oncology (London, England), 2015, Volume: 11, Issue:13 Topics: Economics, Pharmaceutical; Genetic Predisposition to Disease; Humans; Methotrexate; Neurocognitive Disorders; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors	2015
Clinical and laboratory factors associated with interstitial lung disease in rheumatoid arthritis. Clinical rheumatology, 2015, Volume: 34, Issue:9 Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Blood Sedimentation; Disease Progression; Female; Genetic Predisposition to Disease; HLA-DRB1 Chains; Humans; Logistic Models; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Risk Factors; Smoking; Texas	2015
Second primary osteosarcomas in patients with retinoblastoma. Japanese journal of clinical oncology, 2015, Volume: 45, Issue:12 Topics: Adolescent; Adult; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Extremities; Female; Genetic Predisposition to Disease; Humans; Infant; Infusions, Intra-Arterial; Japan; Male; Methotrexate; Neoadjuvant Therapy; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy, Adjuvant; Retinal Neoplasms; Retinoblastoma; Retrospective Studies; Risk Factors; Survivors	2015
Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment. Joint bone spine, 2016, Volume: 83, Issue:1 Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Genotype; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Polymorphism, Genetic; Tumor Necrosis Factor-alpha	2016
Phenotypic Variability in Majeed Syndrome. The Journal of rheumatology, 2016, Volume: 43, Issue:6 Topics: Adolescent; Anemia, Dyserythropoietic, Congenital; Arthritis, Juvenile; Diphosphonates; Follow-Up Studies; Genetic Predisposition to Disease; Genetic Variation; Homozygote; Humans; Immunologic Deficiency Syndromes; Magnetic Resonance Imaging; Male; Methotrexate; Mutation; Nuclear Proteins; Osteomyelitis; Pamidronate; Pedigree; Phenotype; Positron-Emission Tomography	2016
Presence of the methylenetetrahydrofolate reductase gene polymorphism MTHFR C677T in molar tissue but not maternal blood predicts failure of methotrexate treatment for low-risk gestational trophoblastic neoplasia. European journal of pharmacology, 2017, Jan-05, Volume: 794 Topics: Adult; Chorionic Gonadotropin; Female; Genetic Predisposition to Disease; Gestational Trophoblastic Disease; Half-Life; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Molar; Mothers; Pregnancy; Treatment Failure	2017
The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexate. Pharmacogenetics and genomics, 2017, Volume: 27, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Receptor, Adenosine A2A; Rheumatoid Nodule	2017
Low Prevalence of Nodules in Rheumatoid Arthritis Patients in Kuwait: A Description and a Comparison of Patients from the Kuwait Registry for Rheumatic Diseases. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2017, Volume: 26, Issue:2 Topics: Adult; Age Factors; Age of Onset; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Health Status; Humans; Kuwait; Male; Methotrexate; Middle Aged; Prevalence; Rheumatic Nodule; Severity of Illness Index; Sex Factors; Smoking	2017
Association of IL17A and IL17F genes with rheumatoid arthritis disease and the impact of genetic polymorphisms on response to treatment. Immunology letters, 2017, Volume: 183 Topics: Adult; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-17; Male; Methotrexate; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Prognosis; Risk Factors; Severity of Illness Index; Sex Factors; Treatment Outcome	2017
Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis. Arthritis research & therapy, 2017, Feb-02, Volume: 19, Issue:1 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cluster Analysis; Cohort Studies; Female; Gene Expression Profiling; Gene Regulatory Networks; Genetic Predisposition to Disease; Humans; Metalloendopeptidases; Methotrexate; Oligonucleotide Array Sequence Analysis; Receptor, ErbB-2; Sequence Analysis, RNA; Signal Transduction; Tumor Suppressor Protein p53	2017
Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Gene Frequency; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Adenosine A2; Retrospective Studies; Treatment Outcome	2008
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood, 2009, May-07, Volume: 113, Issue:19 Topics: Biomarkers, Tumor; Cation Transport Proteins; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Female; Formins; Gene Dosage; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genetic Variation; Genome, Human; Humans; Infant; Malate Dehydrogenase; Male; Methotrexate; Microfilament Proteins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphoric Monoester Hydrolases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Smad2 Protein; Smad4 Protein; Tumor Suppressor Proteins	2009
Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians. Pharmacogenetics and genomics, 2008, Volume: 18, Issue:12 Topics: Adult; Arthritis, Rheumatoid; Asian People; Biological Availability; Demography; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; India; Male; Methotrexate; Multifactorial Inheritance; Polymorphism, Single Nucleotide; Treatment Outcome	2008
Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease? British journal of haematology, 2009, Volume: 145, Issue:1 Topics: Adolescent; Biomarkers, Tumor; Chi-Square Distribution; Child; Child, Preschool; Disease-Free Survival; Female; Genetic Predisposition to Disease; Genotype; HLA-DP Antigens; HLA-DP beta-Chains; Humans; Immunosuppressive Agents; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Randomized Controlled Trials as Topic; Statistics, Nonparametric; Treatment Outcome	2009
Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice. BMC musculoskeletal disorders, 2009, Feb-19, Volume: 10 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cytokine Receptor gp130; Genetic Predisposition to Disease; Glomerulonephritis; Hyperplasia; Joints; Lymphoid Tissue; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Organ Size; Point Mutation; Species Specificity; Spleen; Stifle	2009
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. Journal of bone and mineral metabolism, 2009, Volume: 27, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Asian People; Female; Fractures, Bone; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Spinal Fractures	2009
Effect of methotrexate on the survival of human lymphocyte cultures carrying MTHFR 677 (C>T) and MTHFR 1298 (A>C) mutations. Drug and chemical toxicology, 2009, Volume: 32, Issue:2 Topics: Alleles; Antirheumatic Agents; Designer Drugs; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Therapy; Female; Genetic Predisposition to Disease; Genotype; Humans; Lymphocytes; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Sensitivity and Specificity; Tumor Cells, Cultured	2009
Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nature genetics, 2009, Volume: 41, Issue:9 Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 7; Cohort Studies; DNA-Binding Proteins; Dopa Decarboxylase; Gene Dosage; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Germ Cells; Germ-Line Mutation; Haplotypes; Humans; Ikaros Transcription Factor; Linkage Disequilibrium; Methotrexate; Odds Ratio; Oncogene Proteins, Fusion; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Probability; Reproducibility of Results; Risk Factors; Trans-Activators; Transcription Factors; White People	2009
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35 Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Gastrointestinal Diseases; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Infant; Linear Models; Linkage Disequilibrium; Liver-Specific Organic Anion Transporter 1; Logistic Models; Male; Methotrexate; Organic Anion Transporters; Phenotype; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome	2009
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1 Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Stomatitis; Vincristine	2010
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct end Pediatric hematology and oncology, 2010, Volume: 27, Issue:1 Topics: Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Daunorubicin; Endothelium, Vascular; Epilepsy, Tonic-Clonic; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Injections, Spinal; Leukoencephalopathies; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Sinus Thrombosis, Intracranial; Vincristine	2010
Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia. Leukemia & lymphoma, 2010, Volume: 51, Issue:4 Topics: Adolescent; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Humans; Male; Membrane Transport Proteins; Methotrexate; Osmolar Concentration; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Treatment Outcome; Young Adult	2010
Race and methotrexate pharmacogenetics in rheumatoid arthritis. The Journal of rheumatology, 2010, Volume: 37, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Racial Groups	2010
Current concepts in the genetic diagnostics of rheumatoid arthritis. Expert review of molecular diagnostics, 2010, Volume: 10, Issue:5 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Sulfasalazine	2010
[Reactive arthritis associated with Chlamydia trachomatis infection: Importance of screening and treating the partner]. Actas dermo-sifiliograficas, 2010, Volume: 101, Issue:8 Topics: Anti-Bacterial Agents; Arthritis, Reactive; Balanitis; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Conjunctivitis, Inclusion; Contact Tracing; Doxycycline; Female; Genetic Predisposition to Disease; HLA-B27 Antigen; Humans; Immunosuppressive Agents; Male; Methotrexate; Sacroiliitis; Sexual Partners; Tattooing; Urethritis; Young Adult	2010
Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-20, Volume: 28, Issue:36 Topics: Adult; Antimetabolites, Antineoplastic; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Studies; Genetic Predisposition to Disease; Humans; Injections, Spinal; Meningioma; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Radiotherapy; Risk Factors; United Kingdom	2010
[Pharmacogenetics and pharmacogenomics of methotrexate. Current status and novel aspects]. Zeitschrift fur Rheumatologie, 2011, Volume: 70, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Genetic Predisposition to Disease; Germany; Humans; Methotrexate; Pharmacogenetics	2011
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy. Fertility and sterility, 2011, Volume: 95, Issue:7 Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Chromosome Aberrations; DNA Fragmentation; Female; Genetic Predisposition to Disease; Humans; Hydatidiform Mole; In Situ Hybridization, Fluorescence; In Situ Nick-End Labeling; Male; Methotrexate; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Ploidies; Pregnancy; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa; Ultrasonography; Uterine Neoplasms	2011
Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients. European journal of clinical pharmacology, 2013, Volume: 69, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Bone Marrow Diseases; Chi-Square Distribution; Cyclin D1; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Risk Factors; Severity of Illness Index; Thymidylate Synthase; Young Adult	2013
Population distribution of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C risk alleles for methotrexate toxicity in Israel. Rheumatology international, 2013, Volume: 33, Issue:4 Topics: Adult; Alleles; Arabs; Demography; Female; Genetic Predisposition to Disease; Genotype; Humans; Israel; Jews; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; White People	2013
HLA-A31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multidrug hypersensitivity marker? Annals of the rheumatic diseases, 2013, Volume: 72, Issue:1* Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; HLA-A Antigens; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged	2013
Association of the Arg194Trp and the Arg399Gln polymorphisms of the XRCC1 gene with risk occurrence and the response to adjuvant therapy among Polish women with breast cancer. Clinical breast cancer, 2013, Volume: 13, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; DNA Repair; DNA-Binding Proteins; Doxorubicin; Epirubicin; Female; Fluorouracil; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Immunoenzyme Techniques; Methotrexate; Neoplasm Invasiveness; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Survival Rate; X-ray Repair Cross Complementing Protein 1	2013
Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis. The Journal of rheumatology, 2002, Volume: 29, Issue:9 Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Antigens, CD; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Italy; Male; Methotrexate; Middle Aged; Odds Ratio; Pharmacogenetics; Polymorphism, Genetic; Prednisone; Probability; Prognosis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reference Values; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex; Sex Distribution; Treatment Outcome	2002
Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation. Transplantation, 2004, Feb-27, Volume: 77, Issue:4 Topics: Adult; Blood Cells; Bone Marrow Transplantation; Chronic Disease; Cohort Studies; Cyclosporine; Drug Therapy, Combination; fas Receptor; Female; Genetic Predisposition to Disease; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Interleukins; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Transplantation, Homologous; Tumor Necrosis Factor-alpha	2004
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis and rheumatism, 2004, Volume: 50, Issue:9 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Immunoglobulin G; Lymphotoxin-alpha; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha	2004
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. Neurology, 2005, Mar-08, Volume: 64, Issue:5 Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine	2005
No evidence of association of methylenetetrahydrofolate reductase polymorphism with occurrence of second neoplasms after treatment of childhood leukemia. Leukemia & lymphoma, 2005, Volume: 46, Issue:6 Topics: Adolescent; Alleles; Antineoplastic Agents; Child; Female; Genetic Predisposition to Disease; Genotype; Humans; Infant; Leukemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms, Second Primary; Odds Ratio; Polymorphism, Genetic; Risk; Sequence Analysis, DNA	2005
The pharmacogenetics of methotrexate in inflammatory bowel disease. Pharmacogenetics and genomics, 2005, Volume: 15, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Case-Control Studies; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; DNA; Female; gamma-Glutamyl Hydrolase; Genetic Predisposition to Disease; Genotype; Humans; Male; Maximum Tolerated Dose; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Transcription Factors; Treatment Outcome	2005
Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study. Rheumatology (Oxford, England), 2006, Volume: 45, Issue:5 Topics: Adolescent; Age of Onset; Autoantibodies; Autoimmune Diseases; Child; Child, Preschool; Environment; Female; Genetic Predisposition to Disease; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; International Cooperation; Male; Methotrexate; Rheumatic Diseases; Risk Factors; Scleroderma, Localized	2006
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:2 Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genetic Variation; Hematologic Diseases; Humans; Infant; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis	2006
Simultaneous occurrence of Wilms tumor and Burkitt lymphoma in two brothers. Pediatric blood & cancer, 2007, Volume: 49, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child, Preschool; Cyclophosphamide; Environmental Exposure; Genetic Predisposition to Disease; Humans; Male; Methotrexate; Prednisone; Risk Factors; Siblings; Vincristine; Wilms Tumor	2007
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma. Journal of human genetics, 2007, Volume: 52, Issue:2 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Infant; Liver Diseases; Lymphoma; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors	2007
Adverse drug reaction to methotrexate: pharmacogenetic origin. The Journal of the American Osteopathic Association, 2006, Volume: 106, Issue:12 Topics: Antimetabolites, Antineoplastic; Female; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mucositis; Neutropenia; Pharmacogenetics; Polymorphism, Single Nucleotide; Thrombocytopenia	2006
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leukemia research, 2008, Volume: 32, Issue:1 Topics: Adult; Child; Child, Preschool; Drug Resistance, Neoplasm; Ethnicity; Female; Genetic Predisposition to Disease; Humans; Indonesia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Netherlands; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tandem Repeat Sequences; Thymidylate Synthase	2008
Dangerous liaisons: drug, host and the environment. Journal of hepatology, 2007, Volume: 46, Issue:6 Topics: Dose-Response Relationship, Drug; Drug Design; Environment; Fibrosis; Genetic Predisposition to Disease; Humans; Liver; Methotrexate; Pharmaceutical Preparations	2007
Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy. International journal of urology : official journal of the Japanese Urological Association, 2007, Volume: 14, Issue:6 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Humans; Inactivation, Metabolic; Leukopenia; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Urologic Neoplasms; Urothelium; Vinblastine	2007
Celiac disease: association with adult-onset Still's disease: apropos of a clinical case. Indian journal of medical sciences, 2007, Volume: 61, Issue:7 Topics: Adult; Autoimmune Diseases; Celiac Disease; Female; Genetic Predisposition to Disease; Humans; Immunoglobulin A; Methotrexate; Risk Factors; Still's Disease, Adult-Onset	2007
[Diagnosis and prognosis study of breast carcinoma with micropapillary component]. Zhonghua bing li xue za zhi = Chinese journal of pathology, 2007, Volume: 36, Issue:4 Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Papillary; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Lymphatic Metastasis; Mastectomy; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Tamoxifen	2007
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. The Journal of pediatrics, 2008, Volume: 152, Issue:1 Topics: Adult; Antimetabolites, Antineoplastic; Attention Deficit Disorder with Hyperactivity; Child; Female; Folic Acid Antagonists; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NAD+); Parents; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Surveys and Questionnaires; Survivors	2008
Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. The Journal of rheumatology, 2008, Volume: 35, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black or African American; Female; Genetic Predisposition to Disease; Humans; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Peptide Synthases; Pharmacogenetics; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Thymidylate Synthase; White People	2008
Pharmacogenomics of methotrexate in rheumatoid arthritis: does race make a difference? The Journal of rheumatology, 2008, Volume: 35, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Racial Groups; Risk Factors	2008
Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma. British journal of cancer, 2000, Volume: 83, Issue:1 Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; England; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Incidence; Leukemia, Myeloid; Leukemia, Radiation-Induced; Life Tables; Methotrexate; Middle Aged; Mitomycin; Mitoxantrone; Myelodysplastic Syndromes; Neoplasms, Second Primary; Prospective Studies; Registries; Risk; Survival Analysis; Tamoxifen; Translocation, Genetic	2000
Primary central nervous system lymphoma in childhood presenting as progressive panhypopituitarism. Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:2 Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Diabetes Insipidus; Disease Progression; Doxorubicin; Dwarfism, Pituitary; False Negative Reactions; Genetic Predisposition to Disease; Human Growth Hormone; Humans; Hydrocortisone; Hypopituitarism; Hypothyroidism; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Pituitary Hormones; Pituitary Neoplasms; Prednisone; Remission Induction; Vincristine	2001
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses. Pharmacogenetics, 2002, Volume: 12, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Retrospective Studies; Treatment Outcome	2002
Treatment for B-cell-type lymphoma in a girl associated with Bloom's syndrome. Clinical genetics, 1992, Volume: 41, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Bloom Syndrome; Child; Chromosome Aberrations; Cyclophosphamide; Doxorubicin; Etoposide; Female; Genetic Predisposition to Disease; Humans; Hydrocortisone; Lymphoma, B-Cell; Methotrexate; Pharyngeal Neoplasms; Prednisolone; Prognosis; Remission Induction	1992