methotrexate has been researched along with Experimental Leukemia in 191 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 181 (94.76) | 18.7374 |
| 1990's | 10 (5.24) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ensminger, WD; Lazarus, H; Rosowsky, A; Yu, CS | 1 |
| Chaykovsky, M; Hirst, M; Lazarus, H; Martinelli, JE | 1 |
| Angier, RB; Child, RG; Citarella, RV; Durr, FE; Fabio, PF; Murdock, KC; Wallace, RE | 1 |
| Beardsley, GP; Ensminger, WD; Lazarus, H; Rosowsky, A; Yu, CS | 1 |
| Griffin, RJ; Meek, MA; Schwalbe, CH; Stevens, MF | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 1 |
| Guo, Z; Hansch, C; Khwaja, TA; Pentecost, S; Selassie, CD | 2 |
| Dias, CB; Hansch, C; Khwaja, TA; Li, R; Selassie, CD | 1 |
| DENNIS, D; GOLDIN, A; GREENHOUSE, SW; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 1 |
| GOLDIN, A; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 3 |
| BELL, M; JOHNSON, S; SCHABEL, FM; SKIPPER, HE; THOMSON, JR | 1 |
| BERNARD, J; MATHE, G; TRAN BA, LO | 1 |
| FISCHER, GA | 3 |
| GOLDIN, A; LYNCH, MR; MEAD, JA; SCHRECKER, AW; VENDITTI, JM | 1 |
| GOLDIN, A; KLINE, I; MEAD, JA; SCHRECKER, AW; VENDITTI, JM | 1 |
| CRAWFORD, E; FRIEDKIN, M; GOLDIN, A; HUMPHREYS, SR | 1 |
| GOLDIN, A; MEAD, JA; SCHRECKER, AW | 1 |
| WOODLIFF, HJ | 1 |
| ONESTI, P; WOODLIFF, HJ | 1 |
| CHIRIGOS, MA; GOLDIN, A; HUMPHREYS, SR; THOMAS, LB | 1 |
| CHIRIGOS, MA; GLYNN, JP; GOLDIN, A; HUMPHREYS, SR; THOMAS, LB | 1 |
| BURCHENAL, JH; LYMAN, M; OETTGEN, HF; PURPLE, J | 1 |
| BURCHENAL, JH | 2 |
| CUTTS, JH | 1 |
| RUTMAN, RJ | 1 |
| JIRASEK, A; JIRASEK, J; MOTYCKA, K; SLAVIK, K; SOUCEK, J | 1 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD; MUSSER, EA | 1 |
| ANKER, HS; RENNERT, OM | 1 |
| CRAWFORD, EJ; FRIEDKIN, M; GOLDIN, A; HUMPHREYS, SR; KASHKET, ER | 1 |
| FISCHER, GA; VONESSEN, CF | 1 |
| GOLDIN, A; HUMPHREYS, SR | 1 |
| BURCHENAL, JH; JOHNSTON, SF; WARING, GB | 1 |
| BURCHENAL, JH; JOHNSTON, SF; WEBBER, LF | 1 |
| Green, HN; Shortridge, D | 1 |
| Hovis, J; Nagai, A; Terata, N; Zbar, B | 1 |
| Dedhar, S; Goldie, JH | 1 |
| Flickinger, RA; Richman, R | 1 |
| Alderson, T; Tyler-Smith, C | 1 |
| Bostock, CJ; Tyler-Smith, C | 1 |
| Ryser, HJ; Shen, WC | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH; Uitendaal, MP | 1 |
| Bellamy, AS; Hill, BT | 1 |
| Hilton, MA; Hoffman, JL; Sparks, MK | 1 |
| Ambaye, RY; Gokhale, SV; Parchure, M | 1 |
| Hoots, WK; Nelson, JA | 1 |
| Berchtold, W; Bürki, H; Laissue, JA | 1 |
| Lokiec, F; Najean, Y; Poirier, O | 1 |
| Dedhar, S; Freisheim, JH; Goldie, JH; Hynes, JB | 1 |
| Barsoum, J; Levinger, L; Varshavsky, A | 1 |
| Aggio, MC; Krauss, S; Latif, ZA; Lozzio, BB; Lozzio, CB; Wust, CJ | 1 |
| Holland, JF; Kamen, BA; Ohnoshi, T; Ohnuma, T; Scanlon, K; Takahashi, I | 1 |
| McCormack, JJ | 1 |
| Palmer, S; Panasci, L; Polizzi, G | 1 |
| Capizzi, RL; Keefe, DA; Rudnick, SA | 1 |
| Ito, A; Nakamura, N; Okada, S; Suzuki, S | 1 |
| Fuska, J; Fusková, A; Proksa, B | 1 |
| Modest, EJ; Rossow, PW; Todd, JA; Tökés, ZA | 1 |
| Dedhar, S; Goldie, JH; Gudauskas, G; Hartley, D; Krystal, G | 1 |
| Nakamura, N; Okada, S | 1 |
| Dedhar, S; Goldie, JH; Krystal, G | 1 |
| Habs, M; Lin, PZ; Schmähl, D | 1 |
| De Traversay, J; Jean, Y; Lemieux, P | 1 |
| Howes, A; Kernan, WJ; Mullenix, PJ; Sallan, SE; Schunior, A; Tarbell, NJ; Waber, DP | 1 |
| Henderson, GB; Saxena, M | 1 |
| Assaraf, YG; Goldman, ID; Zhao, R | 1 |
| Froelich, JJ; Schneller, FR; Zahn, RK | 1 |
| Graham, TC; Sale, GE; Storb, R; Thomas, ED; Weiden, PL | 1 |
| Furusawa, E; Furusawa, S; Lee, JY; Suzuki, N | 1 |
| Bocaccino, CA; Greenberger, JS; Moloney, WC; Szot, SJ | 1 |
| Burchenal, JH; Chisholm, J; Kalaher, K; O'Toole, T | 1 |
| Bleyer, WA; Pizzo, PA; Poplack, DG | 1 |
| Fioretti, MC; Giampietri, A; Goldin, A; Puccetti, P; Riccardi, C | 1 |
| Heidelberger, C; Moran, RG; Mulkins, M | 1 |
| Andreeva, NA; Ershova, IuA; Nemeriuk, MP; Riabokon', NA; Sokolova, AS | 1 |
| Bailey, BD; Goldman, ID; Hill, BT; White, JC | 1 |
| Hryniuk, WM; Kreml, JA; Yamada, EW | 1 |
| Kovarík, J; Svec, F; Zemanová, D | 1 |
| Holland, JF; Silver, RT; Young, RC | 1 |
| Harmon, JM; Norman, MR; Thompson, EB | 1 |
| Baygell, PD; Leyva, A; Pinedo, HM; Pintus, C; Spreafico, F; van Asten, P; van Loenen, AC | 1 |
| Fung, WP; Przybylski, M; Ringsdorf, H; Zaharko, DS | 1 |
| Albrecht, AM | 1 |
| Goldie, JH; Harrison, SI; Hill, BT; Price, LA | 1 |
| Bender, RA; Nichols, AP; Warren, RD | 1 |
| Holland, JF; Ohnuma, T; Takahashi, I | 1 |
| Goldie, JH; Hill, BT | 1 |
| Goldin, A | 1 |
| Arsenian, FG; Iurkevich, AM; Miasishcheva, NV; Sof'ina, ZP | 1 |
| Fujikura, R; Inaba, M; Sakurai, Y | 1 |
| Hill, BT; Price, LA | 1 |
| Blakley, RL; Groff, JP | 1 |
| Balázová, E; Koza, I; Ujházy, V | 1 |
| Gang, M; Garibjanian, BT; Goldin, A; Johnson, RK; Kline, I; Vadlamudi, S; Venditti, JM | 1 |
| Culvenor, J; Harding, B; MacLennan, IC | 1 |
| Bosmann, HB; Hakimi, J | 1 |
| Bertino, JR; Chello, PL | 1 |
| Goldies, JH; Hill, BT; Price, LA | 1 |
| Burchenal, JH; Currie, VE; Dowling, MD; Fox, JJ; Krakoff, IH | 1 |
| Reif, AE; Robinson, CM; Smith, PJ | 1 |
| Grindey, GB; Moran, RG | 1 |
| Lukasewycz, OA; Martinez, D; Murphy, WH | 1 |
| Sakurai, Y | 1 |
| Pinkerton, H; Rana, MW; Rankin, A | 1 |
| Béderová, E; Svec, F; Svec, P | 1 |
| Liliemark, J; Peterson, C; Pettersson, B | 1 |
| Prochownik, EV; Smith, MJ | 1 |
| Christopherson, RI; Lyons, SD; Phillips, L; Sant, ME | 1 |
| Koizumi, S; Nakarai, T; Ueno, Y | 1 |
| Akhtar, R; Rogers, AE; Zeisel, SH | 1 |
| Bertino, JR; Hsieh, P; McGuire, JJ; Mini, E | 1 |
| Capizzi, RL; Fernandes, DJ; Kute, TE; Sur, P | 2 |
| Avery, TL; Blakley, RL; Brixner, DI; Broom, AD; Kuehl, M | 1 |
| Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG | 1 |
| Holland, JF; Kano, Y; Ohnuma, T | 1 |
| Omote, Y | 1 |
| Bolanowska, WE; McGuire, JJ; Piper, JR | 1 |
| Al-Ansari, HM; Farkas, WR; Walden, TL | 1 |
| Corin, RE; Szabo, P; Turner, T | 1 |
| Goldin, A; Wittes, RE | 1 |
| Mandelbaum-Shavit, F; Ramu, A | 1 |
| Abels, J; Kroes, AC; Lindemans, J; Schoester, M | 1 |
| Storek, J | 1 |
| Iland, HJ; Laszlo, J; Sedwick, WD | 1 |
| Hoshino, A; Ito, Y; Machida, S | 1 |
| Fridkin, M; Ramu, A; Steinherz, R | 1 |
| Cottam, HB; McKernan, PA; Petrie, CR; Revankar, GR; Robins, RK | 1 |
| Abelson, HT; Dolnick, BJ; Kamen, BA; Nylen, PA; Peterson, DW; Whitehead, VM | 1 |
| Motycka, K | 1 |
| Aoshima, M; Sakurai, Y | 1 |
| Burchenal, JH; Dowling, MD; Tan, CT | 1 |
| Rosowsky, A | 1 |
| Chaykovsky, M; Chen, KK; Gaumont, Y; Kisliuk, RL; Modest, EJ; Papathanasopoulos, N; Rosowsky, A | 1 |
| Chen, KK; Rosowsky, A | 1 |
| Bradner, WT; Pindell, MH | 1 |
| Chu, MY; Hoovis, ML | 2 |
| Sanada, H; Taguchi, H | 1 |
| Gang, M; Kline, I; Tyrer, DD; Venditti, JM; Waravdekar, VS | 1 |
| Bukin, IuV; Raushenbakh, MO; Sergeev, AV | 1 |
| Capizzi, RL; Nahas, A | 1 |
| Galegov, GA; Shobukhov, VM | 1 |
| Mead, JA; Mishra, LC | 1 |
| Amiel, JL; De Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Pouillart, P; Rappaport, H; Rosenfeld, C; Schneider, M; Schwarzenberg, L; Weiner, R | 1 |
| Bleyer, WA; Yancey, ST | 1 |
| Harrap, KR; Tattersall, MH | 1 |
| Borsos, T; Goldin, A; Loos, M; Meltzer, M; Shifrin, S; Vadlamudi, S | 1 |
| Adamson, RH; Hahn, MA | 1 |
| Furness, ME; Harrap, KR; Jackson, S; Tattersall, MH | 1 |
| Hutchison, DJ; Schmid, FA; Stock, CC; Tarnowski, GS | 1 |
| Choi, SC; Goldin, A; Straus, MJ | 1 |
| Goldin, A; Krishna, B; Reddy, VV; Vadlamudi, S | 1 |
| Goldie, JH; Hill, BT; Price, LA | 1 |
| Hebborn, P; Mishra, LC | 1 |
| Buchman, VM; Kozlova, MD; Levin, VJ; Mikaelian, SE; Radzichovskaya, RM; Svet-Moldavsky, GJ | 1 |
| Kensler, CJ; Swiniarski, J; Venditti, JM; Wodinsky, I | 1 |
| Ivankovic, S; Zeller, WJ | 1 |
| Baldini, L; Brambilla, G; Cavanna, M; Parodi, S | 1 |
| Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS | 1 |
| Roberts, D | 1 |
| Hutchison, DJ; Schmid, FA | 2 |
| Lamerton, LF | 1 |
| Hryniuk, WM | 1 |
| Courtenay, VD; Robins, AB | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 1 |
| Brambilla, G; Caraceni, CE; Cavanna, M; Parodi, S | 1 |
| Conklin, JW; Jenkins, VK; Tyndall, RL; Upton, AC; Walburg, HE; Wald, N | 1 |
| Hirshaut, Y; Perry, S; Weiss, GH | 1 |
| Bertino, JR; Capizzi, RL; Summers, WP | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Borsa, J | 1 |
| Amiel, JL; Cattan, A; Mathé, G; Pouillart, P; Schneider, M; Schwarzenberg, L | 1 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Hutchison, DJ; Schmid, FA; Shimoyama, M | 1 |
| Boyse, EA; Campbell, HA; Mashburn, LT; Old, LJ | 1 |
| Kessel, D | 1 |
| Bertino, JR; Fischer, GA; Hryniuk, WM | 1 |
| Blumenthal, G; Greenberg, DM | 1 |
| Andrysek, O; Coufalová, H; Jehlicková, M; Motycka, K; Stránská, E | 1 |
| Chu, MY; Fischer, GA | 1 |
| Roberts, D; Wodinsky, I | 1 |
| Hoshino, A | 1 |
| Hall, TC; Kessel, D; Roberts, D; Wodinsky, I | 1 |
| Skipper, HE | 1 |
8 review(s) available for methotrexate and Experimental Leukemia
| Article | Year |
|---|---|
Dihydrofolate reductase inhibitors as potential drugs.
Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi | 1981 |
Studies with high-dose methotrexate--historical background.
Topics: Aminopterin; Animals; Folic Acid; History, 20th Century; Humans; Leucovorin; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Time Factors | 1978 |
Murine and human leukemias.
Topics: Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred AKR; Prednisone; Vincristine | 1975 |
Unresolved issues in combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carmustine; Cell Cycle; Cyclophosphamide; Dacarbazine; Drug Evaluation; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Fluorouracil; Humans; Leukemia, Experimental; Metabolic Clearance Rate; Methotrexate; Neoplasm Transplantation | 1986 |
Overcoming methotrexate resistance by a lipophilic antifolate (BW 301U): from theory to models to practice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Line; DNA; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia, Experimental; Methotrexate; Mice; Models, Biological; Phenotype; Pyrimethamine; Pyrimidines | 1985 |
Treatment of acute lymphoblastic leukemia.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Cytopathogenic Effect, Viral; Daunorubicin; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Meninges; Mercaptopurine; Methotrexate; Mice; Oncogenic Viruses; Patient Care Team; Remission, Spontaneous; Reverse Transcriptase Inhibitors; RNA Viruses; RNA-Directed DNA Polymerase; Time Factors; Vincristine | 1972 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
In search of a key.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; DNA, Neoplasm; Drug Combinations; Humans; In Vitro Techniques; Leukemia; Leukemia, Experimental; Leukocytes; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1971 |
1 trial(s) available for methotrexate and Experimental Leukemia
| Article | Year |
|---|---|
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
183 other study(ies) available for methotrexate and Experimental Leukemia
| Article | Year |
|---|---|
Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.
Topics: Amides; Animals; Antineoplastic Agents; Cells, Cultured; Chromatography, Thin Layer; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Methotrexate; Mice; Rats | 1977 |
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues.
Topics: Animals; Antineoplastic Agents; Cell Line; Folic Acid Antagonists; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Male; Methods; Methotrexate; Mice; Thymidylate Synthase | 1977 |
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones.
Topics: Animals; Anthracenes; Antineoplastic Agents; Leukemia, Experimental; Mice; Neoplasms, Experimental; Structure-Activity Relationship | 1979 |
Methotrexate analogues. 11. Unambiguous chemical synthesis and in vitro biological evaluation of alpha- and gamma-monoesters as potential prodrugs.
Topics: Animals; Biotransformation; Cell Division; Cells, Cultured; Esterases; Esterification; Folic Acid Antagonists; Humans; In Vitro Techniques; Isomerism; Leukemia, Experimental; Methotrexate; Species Specificity | 1978 |
Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor c
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Crystallization; Folic Acid Antagonists; Leukemia, Experimental; Liver; Methotrexate; Mice; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L5178; Leukemia, Experimental; Mathematics; Methotrexate; Mice; Structure-Activity Relationship; Triazines | 1984 |
Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types.
Topics: Animals; Antineoplastic Agents; Cattle; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Folic Acid Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia, Experimental; Mice; Structure-Activity Relationship | 1982 |
A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate.
Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Leukemia, Experimental; Liver; Methotrexate; Mice; Triazines | 1982 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Pyrimidines; Solubility | 1982 |
An investigation into the synergistic antileukemic action of amethopterin and 6-mercaptopurine in mice.
Topics: Animals; Folic Acid Antagonists; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Purines | 1955 |
Combined treatment of advanced leukemia (L1210) in mice with amethopterin and 6-mercaptopurine.
Topics: Animals; Combined Modality Therapy; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice | 1956 |
On the curability of experimental neoplasms. I. Amethopterin and mouse leukemias.
Topics: Animals; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Neoplasms, Experimental | 1957 |
The influence of amethopterin on the survival time of leukemic mice with respect to food intake, body weight changes, and tumor growth.
Topics: Animals; Body Weight; Eating; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Nutritional Sciences | 1958 |
[Effect on mouse leukemia 1210 of a combination by diazo-reaction of amethopterin and gamma-globulins from hamsters inoculated with such leukemia by heterografts].
Topics: Animals; Cricetinae; Folic Acid Antagonists; gamma-Globulins; Heterografts; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1958 |
Prolongation of the lifespan of mice with advanced leukemia (L1210) by treatment with halogenated derivatives of amethopterin.
Topics: Animals; Ascorbic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice; Vitamins | 1959 |
Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells.
Topics: Animals; Biochemical Phenomena; Enzymes; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Tetrahydrofolate Dehydrogenase | 1961 |
Effect of orally administered 3', 5'-dichloroamethopterin on formate-C14 incorporation in leukemic mice.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Formates; Leukemia, Experimental; Methotrexate; Mice | 1960 |
Influence of the route of administration on the relative effectiveness of 3',5'-dichloroamethopterin and amethopterin against advanced leukemia (L1210) in mice.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1960 |
The association of increased dihydrofolate reductase with amethopterin resistance in mouse leukemia.
Topics: Animals; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice; Oxidoreductases; Tetrahydrofolate Dehydrogenase | 1962 |
Incorporation of formate-C-14 in normal and leukemic mice during extended treatment with amethopterin and 3',5'-dichloramethopterin.
Topics: Animals; Folic Acid Antagonists; Formates; Leukemia, Experimental; Liver; Methotrexate; Mice; Spleen | 1962 |
Detective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells.
Topics: Antimetabolites; Biological Transport; Leukemia; Leukemia, Experimental; Methotrexate | 1962 |
THE EFFECT OF ANTIMETABOLITES ON THE RESPIRATION OF LEUKEMIC MOUSE CELLS.
Topics: Animals; Antimetabolites; Cell Respiration; Leukemia; Leukemia, Experimental; Mercaptopurine; Metabolism; Methotrexate; Mice; Research | 1963 |
EFFECT OF DRUGS ON CELLS IN VITRO.
Topics: Animals; Busulfan; Glioma; In Vitro Techniques; Leukemia; Leukemia, Experimental; Leukemia, Myeloid; Mannitol; Methotrexate; Mice; Nitrogen Mustard Compounds; Pharmacology; Research | 1963 |
DEVELOPMENT OF MENINGEAL LEUKEMIA (L1210) DURING TREATMENT OF SUBCUTANEOUSLY INOCULATED MICE WITH METHOTREXATE.
Topics: Animals; Arachnoid; Leukemia; Leukemia, Experimental; Meninges; Methotrexate; Mice; Pathology; Research | 1964 |
THERAPEUTIC AND IMMUNOLOGICAL RESPONSE OF MICE WITH MENINGEAL LEUKEMIA (L1210) TO CHALLENGE WITH AN ANTIFOLIC-RESISTANT VARIANT.
Topics: Animals; Cyclophosphamide; Folic Acid Antagonists; Leukemia; Leukemia L1210; Leukemia, Experimental; Meninges; Methotrexate; Mice; Neoplasms; Pathology; Radiation Effects; Research | 1964 |
THE CORRELATION BETWEEN TRANSPLANTED MOUSE AND HUMAN ACUTE LEUKEMIAS.
Topics: Aldehydes; Anilides; Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Vincristine | 1964 |
III. IMPROVEMENT OF CANCER CHEMOTHERAPY IN MAN.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorouracil; Leukemia; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Pyrimidines; Research; Stilbamidines; Triparanol | 1964 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Research; Thioguanine; Thiotepa; Toxicology | 1964 |
THE TREATMENT OF EXPERIMENTAL MOUSE HEMOBLASTOSIS. I. THE EFFECT OF SOME NEW FOLIC ACID ANTIMETABOLITES ON CELL TRANSPLANTED LEUKEMIA IN MICE OF THE AKR STRAIN.
Topics: Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Folic Acid; Leukemia; Leukemia, Experimental; Leukocyte Count; Methotrexate; Mice; Mice, Inbred AKR; Pharmacology; Research; Toxicology | 1964 |
THE EFFECT OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE HYDROCHLORIDE ON MURINE NEOPLASMS.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Blood Cells; Carcinoma, Ehrlich Tumor; Cortisone; Cytarabine; Cytosine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
EFFECT OF 5',5',5'-TRIFLUOROLEUCINE ON A NUMBER OF MOUSE LEUKAEMIAS.
Topics: Amino Acids; Animals; Chromatography; Hair; Leucine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Research; Skin | 1964 |
ON THE SIMILARITY OF DIHYDROFOLATE REDUCTASES FROM AMETHOPTERIN-SENSITIVE AND AMETHOPTERIN-RESISTANT MOUSE LEUKEMIA (L1210) CELLS.
Topics: Animals; Benzoates; Enzyme Inhibitors; Folic Acid; Leukemia; Leukemia, Experimental; Methotrexate; Mice; NADP; Oxidoreductases; Pharmacology; Research; Sodium Chloride; Tetrahydrofolate Dehydrogenase | 1964 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Experimental; Mast Cells; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimethamine; Radiation Genetics; Research; Tissue Culture Techniques | 1965 |
Investigation of tumor variants recovered from mice with systemic leukemia (L1210) after extensive therapy with 3',5'-dichloroamethopterin and 3'-bromo-5'-chloroamethopterin.
Topics: Animals; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1959 |
Mechanisms of amethopterin resistance in leukemia. I. Effects of weak folic acid antagonists on mouse leukemias.
Topics: Animals; Biochemical Phenomena; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Methotrexate | 1951 |
Mechanisms of amethopterin resistance in leukemia. II. Effect of cortisone on sensitive and resistant mouse leukemias.
Topics: Animals; Cortisone; Leukemia; Leukemia, Experimental; Methotrexate; Mice | 1951 |
Effect of cyclophosphamide, 6-mercaptopurine or methotrexate on the Furth rat leukaemia.
Topics: Animals; Cyclophosphamide; Female; Freund's Adjuvant; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Rats | 1967 |
Tumor rejection mediated by an amphotropic murine leukemia virus.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Fibrosarcoma; Guinea Pigs; Leukemia Virus, Murine; Leukemia, Experimental; Male; Methotrexate; Neoplasm Transplantation; RNA-Directed DNA Polymerase; Skin Neoplasms | 1983 |
Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line.
Topics: Animals; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Isoenzymes; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1983 |
The effect of induction of hemoglobin synthesis in cultured Friend cells on the number of initiation sites for replication and transcription.
Topics: Acetamides; Aminoisobutyric Acids; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; DNA Replication; Floxuridine; Hemoglobins; Kinetics; Leukemia, Experimental; Methotrexate; Mice; Transcription, Genetic | 1984 |
Gene amplification in methotrexate-resistant mouse cells. I. DNA rearrangement accompanies dihydrofolate reductase gene amplification in a T-cell lymphoma.
Topics: Animals; Cell Line; Chromosome Mapping; DNA; DNA Restriction Enzymes; Drug Resistance; Gene Amplification; Genes; Leukemia, Experimental; Lymphoma; Methotrexate; Mice; RNA, Messenger; T-Lymphocytes; Tetrahydrofolate Dehydrogenase | 1981 |
Gene amplification in methotrexate-resistant mouse cells. III. Interrelationships between chromosome changes and DNA sequence amplification or loss.
Topics: Animals; Cell Line; Chromosome Aberrations; DNA; DNA Restriction Enzymes; Drug Resistance; Gene Amplification; Leukemia, Experimental; Lymphoma; Methotrexate; Mice; T-Lymphocytes; Tetrahydrofolate Dehydrogenase | 1981 |
Selective killing of Fc-receptor-bearing tumor cells through endocytosis of a drug-carrying immune complex.
Topics: Animals; Antigen-Antibody Complex; Cell Line; Cytotoxicity, Immunologic; Endocytosis; Female; Humans; Immunotherapy; Leukemia, Experimental; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Mice; Ovarian Neoplasms; Phagocytosis; Receptors, Fc; Serum Albumin | 1984 |
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1984 |
Murine L5178Y cells resulting in altered drug sensitivities from fractionated radiation exposure in vitro.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Hydroxyurea; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Vincristine | 1984 |
Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on survival of leukemic mice and on concentrations of liver adenosylamino acids.
Topics: Animals; Diet; Homocysteine; Homocystine; Kinetics; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Liver; Male; Methotrexate; Mice; Mice, Inbred DBA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Combination of anticancer agents with folic acid in the treatment of murine leukaemia P388.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Fluorouracil; Folic Acid; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mitomycins | 1984 |
Treatment of murine testicular leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Leukemia P388; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred DBA; Testicular Neoplasms; Vincristine | 1984 |
Survival of tumor-bearing mice exposed to heavy water or heavy water plus methotrexate.
Topics: Animals; Cell Line; Deuterium; Female; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasm Transplantation; Probability; Sarcoma, Experimental; Time Factors | 1982 |
[Enhancement by sodium butyrate of the cytotoxic effect of methotrexate on leukemic cells].
Topics: Animals; Butyrates; Butyric Acid; Cell Division; Drug Synergism; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice | 1982 |
Inhibition of a methotrexate-insensitive dihydrofolate reductase from L5178Y cells by substituted triazines and quinazolines.
Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Quinazolines; Triazines | 1983 |
On the chromatin structure of the amplified, transcriptionally active gene for dihydrofolate reductase in mouse cells.
Topics: Animals; Cells, Cultured; Chromatin; Cloning, Molecular; DNA; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Genes; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Nucleic Acid Hybridization; Nucleosomes; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 1982 |
Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice.
Topics: Animals; Antibodies, Neoplasm; Antibody Specificity; Antineoplastic Agents; Chlorambucil; Daunorubicin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leukemia, Experimental; Leukemia, Myeloid, Acute; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1980 |
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Interactions; Drug Resistance; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase | 1982 |
Diminished toxicity of methotrexate in CD2F1 mice pretreated with cycloheximide.
Topics: Animals; Cycloheximide; Injections, Intraperitoneal; Lethal Dose 50; Leukemia P388; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Protein Biosynthesis; Time Factors | 1982 |
Methotrexate cytotoxicity for L5178Y/Asn- lymphoblasts: relationship of dose and duration of exposure to tumor cell viability.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Administration Schedule; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Models, Biological; Time Factors | 1982 |
Mutations induced by gamma-rays and fast neutrons in cultured mammalian cells. Differences in dose response and RBE with methotrexate-and 6-thioguanine-resistant systems.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Drug Resistance; Fast Neutrons; Gamma Rays; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Mutation; Thioguanine | 1982 |
7,8-dihydro-5H-isoindolo[1,2-b] [3]benzazepine-5-ones. Part 2: In vitro effect of derivatives substituted at position 7 on leukemia P 388 cells.
Topics: Animals; Antineoplastic Agents; Benzazepines; Cell Division; Chemical Phenomena; Chemistry; Drug Synergism; In Vitro Techniques; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Proteins; Structure-Activity Relationship; Time Factors; Uridine | 1982 |
Liposome encapsulation enhancement of methotrexate sensitivity in a transport resistant human leukemic cell line.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Humans; Leukemia, Experimental; Liposomes; Methotrexate | 1982 |
A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells.
Topics: Animals; Cell Line; Cell Survival; Chromatography, Affinity; Chromatography, High Pressure Liquid; Drug Resistance; Folic Acid Antagonists; Genetic Variation; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1980 |
Dose-rate effects of gamma-ray-induced mutations in cultured mammalian cells.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Drug Resistance; Gamma Rays; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Mutation; Thioguanine | 1981 |
Properties of a methotrexate-insensitive variant of dihydrofolate reductase derived from methotrexate-resistant L5178Y cells.
Topics: Animals; Drug Resistance; Genetic Variation; Isoenzymes; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Molecular Weight; Tetrahydrofolate Dehydrogenase | 1981 |
Carcinogenic activity in rats of combined treatment with cyclophosphamide, methotrexate and 5-fluorouracil.
Topics: Adrenal Gland Neoplasms; Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukemia, Experimental; Male; Mammary Neoplasms, Experimental; Methotrexate; Neoplasms, Experimental; Nervous System Neoplasms; Rats; Urinary Bladder Neoplasms | 1981 |
Teaching cancer chemotherapy by means of a computer simulation.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cause of Death; Computer Simulation; Computer-Assisted Instruction; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Leukemia, Experimental; Melanoma; Methotrexate; Mice; Models, Biological; Models, Educational; Neoplasms, Experimental; Sarcoma, Experimental; Software; Survival Rate; Teaching | 1994 |
Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia.
Topics: Animals; Behavior, Animal; Brain; Child; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Humans; Leukemia, Experimental; Male; Methotrexate; Nervous System; Prednisolone; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley | 1994 |
Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 Cells.
Topics: Adenosine Triphosphate; Animals; Anions; Dose-Response Relationship, Drug; Ion Transport; Kinetics; Leukemia, Experimental; Methotrexate; Mice | 1996 |
A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate.
Topics: Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Leucovorin; Leukemia, Experimental; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutation; Substrate Specificity; Tumor Cells, Cultured | 1998 |
The influence of radiation and chemotherapy-related DNA strand breaks on carcinogenesis: an evaluation.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cisplatin; Dactinomycin; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Etoposide; Leukemia, Experimental; Methotrexate; Mice; Tumor Cells, Cultured; Vincristine | 1999 |
Allogeneic hematopoietic grafts after total-body irradiation in dogs with spontaneous tumors.
Topics: Animals; Antilymphocyte Serum; Bone Marrow Transplantation; Dogs; Female; Graft Rejection; Graft vs Host Reaction; Leukemia, Experimental; Lymphoma; Male; Methotrexate; Neoplasms, Experimental; Radiotherapy Dosage; Recurrence; Remission, Spontaneous; T-Lymphocytes; Transplantation, Autologous; Transplantation, Homologous | 1978 |
Combination chemotherapy of Rauscher leukemia and ascites tumors by narcissus alkaloid with standard drugs and effect on cellular immunity.
Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Blood Cells; Carcinoma, Ehrlich Tumor; Carmustine; Cells, Cultured; Cyclophosphamide; Dactinomycin; Daunorubicin; Drug Synergism; Drug Therapy, Combination; Emetine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Inbred BALB C; Plants, Medicinal; Rauscher Virus; Spleen; Streptonigrin; Vincristine | 1975 |
Chemotherapeutic remissions in Wistar Furth rat acute myelogenous leukemia: a model for human AML.
Topics: Animals; Antineoplastic Agents; Busulfan; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Dexamethasone; Disease Models, Animal; Doxorubicin; Leukemia, Experimental; Leukemia, Myeloid, Acute; Methotrexate; Rats; Remission, Spontaneous; Vinblastine; Vincristine | 1977 |
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1977 |
Experimental approaches to the treatment of CNS leukemia.
Topics: Animals; Antineoplastic Agents; Catheters, Indwelling; Central Nervous System Diseases; Dose-Response Relationship, Drug; Half-Life; Haplorhini; Humans; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Leukemia, Experimental; Macaca mulatta; Methotrexate; Perfusion | 1979 |
Growth and rejection patterns of murine lymphoma cells antigenically altered following drug treatment in vivo.
Topics: Animals; Antigens, Neoplasm; Dacarbazine; DNA; Floxuridine; Graft Rejection; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Transplantation; Transplantation, Homologous; Triazenes | 1978 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1979 |
[Tomizine--a new inhibitor of folate metabolism enzymes possessing an antitumor activity].
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasms, Experimental; Rats; Sarcoma 37; Sarcoma, Experimental; Thiazines | 1975 |
Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.
Topics: 4-Chloromercuribenzenesulfonate; Aminopterin; Animals; Azides; Biological Transport; Cell Line; Cell Membrane; Drug Resistance; Formyltetrahydrofolates; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolates | 1979 |
Effect of methotrexate on cyclic AMP levels in cultured L5178Y cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic AMP; Hypoxanthines; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Time Factors | 1979 |
Experimental chemotherapy of rat leukemia RBA-Le with cis-diamminedichloroplatinum.
Topics: Animals; Cisplatin; Cyclophosphamide; Drug Therapy, Combination; Female; Leukemia, Experimental; Leukemia, Myeloid; Male; Methotrexate; Poly I-C; Rats | 1977 |
Some new aspects of modern cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Daunorubicin; Drug Therapy, Combination; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mitosis; Neoplasms; Neuraminidase; Prednisone; Vincristine | 1977 |
Use of a human lymphoid cell line to evaluate interactions between prednisolone and other chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Clone Cells; Drug Interactions; Drug Therapy, Combination; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasms, Hormone-Dependent; Prednisolone; Vincristine | 1978 |
Characterization of methotrexate recovered from the urine of high dose patients for the purpose of clinical re-use.
Topics: Adolescent; Adult; Animals; Chromatography, Ion Exchange; Female; Humans; Leukemia, Experimental; Male; Methotrexate; Mice; Osteosarcoma; Pyrogens; Spectrophotometry, Ultraviolet | 1978 |
In vitro inhibitory effects of polymer-linked methotrexate derivatives on tetrahydrofolate dehydrogenase and murine L5178Y cells.
Topics: Animals; Carboxymethylcellulose Sodium; Cells, Cultured; Folic Acid Antagonists; Leukemia, Experimental; Macromolecular Substances; Methotrexate; Mice; Polyethyleneimine; Polylysine; Polymers; Pyran Copolymer | 1979 |
Regulatory control of tetrahydrofolate coenzymes in folate auxotrophs.
Topics: Animals; Culture Media; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leucovorin; Leukemia, Experimental; Methotrexate; Mice; Streptococcus; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 1977 |
The difference between "selective folinic acid protection" and "folinic acid rescue" in L5178Y cells culture.
Topics: Animals; Cell Line; Cell Survival; Leucovorin; Leukemia, Experimental; Lymphocytes; Methotrexate; Pyrimethamine | 1977 |
Membrane transport of methotrexate in human lymphoblastoid cells.
Topics: Animals; Antimetabolites; Biological Transport, Active; Cell Line; Cell Membrane; Folic Acid; Humans; Kinetics; Leucovorin; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Temperature | 1978 |
A comparison of the biological effects of dichloromethotrexate and methotrexate on human leukemic cells in culture.
Topics: Animals; Cell Division; Cell Line; Humans; Leucovorin; Leukemia, Experimental; Methotrexate; Serum Albumin | 1979 |
An apparent relationship between responsiveness to folinic acid protection from methotrexate cytotoxicity and uptake of 5-methyltetrahydrofolate in a series of murine cell lines.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Kinetics; Leucovorin; Leukemia L1210; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolates | 1979 |
[Possibility of potentiating the antineoplastic effect of a folic acid antagonist by methylcobalamin analogs].
Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Female; Folic Acid Antagonists; Hybridization, Genetic; Intestinal Neoplasms; Leukemia, Experimental; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Neoplasms, Experimental; Quinolinium Compounds; Uterine Cervical Neoplasms; Vitamin B 12 | 1979 |
Comparative study of in vivo development of resistance to various classes of antitumor agents in P388 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance; Female; Fluorouracil; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation | 1979 |
Superiority of adriamycin-14-octanoate over adriamycin in reducing viability of methotrexate-resistant L5178Y cells: brief communication.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; DNA-Directed RNA Polymerases; Doxorubicin; Drug Resistance; In Vitro Techniques; Leukemia, Experimental; Methotrexate | 1977 |
Rescue of human lymphoid cells from the effects of methotrexate in vitro.
Topics: Animals; Cell Line; Drug Interactions; Drug Resistance; Formyltetrahydrofolates; Humans; Leukemia, Experimental; Lymphocyte Activation; Lymphocytes; Methotrexate; Models, Biological; Phytohemagglutinins; Tetrahydrofolates | 1978 |
Combined chemoimmunotherapy of L5178Y lymphoma.
Topics: Animals; Antigens, Neoplasm; BCG Vaccine; Female; Immunotherapy; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Transplantation, Homologous | 1978 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Tegafur | 1976 |
Effects of varying the interval between courses of methotrexate on its myelotoxic and anti-leukaemic activities.
Topics: Animals; Body Weight; Bone Marrow Cells; Cell Count; Dose-Response Relationship, Drug; Leukemia, Experimental; Leukocyte Count; Methotrexate; Neoplasm Transplantation; Neutropenia; Neutrophils; Rats; Time Factors; Transplantation, Isogeneic | 1977 |
Collateral sensitivity: problems of demonstration in murine leukemia cells.
Topics: Animals; Asparaginase; Cell Division; Cell Line; Drug Resistance; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1977 |
Effect of methionine deprivation on L5178Y murine leukemia cells in culture interference with the antineoplastic effect of methotrexate.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Leukemia, Experimental; Methionine; Methotrexate; Mice; Time Factors | 1976 |
The value of adriamycin in overcoming resistance to methotrexate in tissue culture.
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Dinitrophenols; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Methotrexate; Temperature | 1976 |
Experimental and clinical studies on nucleoside analogs as antitumor agents.
Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leukemia, Experimental; Male; Methotrexate; Mice; Nasopharyngeal Neoplasms; Structure-Activity Relationship | 1975 |
Preparation and therapeutic potential of rabbit antisera with "directed" specificities for mouse leukemias.
Topics: Animals; Antigens, Neoplasm; Drug Resistance; Female; Hemagglutination; Immune Sera; Immunization; Immunization, Passive; Leukemia L1210; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred DBA; Rabbits | 1976 |
Effects of allopurinol on the therapeutic efficacy of methotrexate.
Topics: Allopurinol; Animals; Chick Embryo; Female; Hypoxanthines; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1975 |
Immune mechanisms in leukemia: suppression of cellular immunity by drugs and x-irradiation.
Topics: Animals; Cyclophosphamide; Female; Immunity, Cellular; Immunity, Maternally-Acquired; Immunization Schedule; Immunization, Passive; Immunologic Memory; Immunosuppression Therapy; Leukemia, Experimental; Lymphocytes; Male; Methotrexate; Mice; Prednisolone; Radiation Effects; Spleen | 1975 |
Sensitivity of DBLA-6 leukemia of rats to known antitumor agents in relation to their clinical effects.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Line; Cyclophosphamide; Cytarabine; Daunorubicin; Injections, Intravenous; Leukemia, Experimental; Mercaptopurine; Methotrexate; Nitrosourea Compounds; Rats; Vinblastine; Vincristine | 1975 |
Effect of rifamycin and tilorone derivatives on Friend virus leukemia in mice.
Topics: Adjuvants, Pharmaceutic; Animals; Fluorenes; Friend murine leukemia virus; Leukemia, Experimental; Methotrexate; Mice; Organ Size; Rifamycins; Spleen; Tilorone | 1975 |
The effect of long-term administration of N-(2-hydroxyethyl)palmitamide on the chemotherapy of RBA rat leukemia.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Drug Therapy, Combination; Leukemia, Experimental; Methotrexate; Methylcellulose; Palmitic Acids; Rats; Vincristine | 1975 |
On the biochemical modulation of 6-mercaptopurine by methotrexate in murine WEHI-3b leukemia cells in vitro.
Topics: Animals; Drug Interactions; Extracellular Space; Hypoxanthine; Hypoxanthines; Inosine Monophosphate; Kinetics; Leukemia, Experimental; Leukemia, Myelomonocytic, Acute; Mercaptopurine; Methotrexate; Mice; Phosphoribosyl Pyrophosphate; Purines; Thionucleotides; Tumor Cells, Cultured; Xanthines | 1992 |
Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Dexamethasone; DNA, Antisense; Genes, jun; Kinetics; Leukemia, Experimental; Methotrexate; Mice; Plasmids; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; RNA, Neoplasm; Transcription, Genetic | 1992 |
Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells.
Topics: Amidophosphoribosyltransferase; Aminoimidazole Carboxamide; Animals; Azaserine; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Methylthioinosine; Mice; Purines; Pyrimidines; Ribonucleotides; Tumor Cells, Cultured | 1992 |
Paradoxical enhancement of interleukin-2-mediated cytotoxicity against K562 cells by addition of a low dose of methotrexate.
Topics: Adult; Antigens, Differentiation; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunity, Cellular; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Leukemia, Experimental; Leukocytes, Mononuclear; Methotrexate; Phenotype; Receptors, Fc; Receptors, IgG; Tumor Cells, Cultured | 1990 |
Procarbazine carcinogenicity in methotrexate-treated or lipotrope-deficient male rats.
Topics: Animals; Carcinogens; Choline Deficiency; Leukemia, Experimental; Lipid Metabolism; Liver; Male; Mammary Neoplasms, Experimental; Methotrexate; Neoplasms, Experimental; Procarbazine; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.
Topics: Cell Survival; Drug Synergism; Fluorouracil; Humans; Leukemia, Experimental; Methotrexate; Peptides; Polyglutamic Acid | 1985 |
L-asparaginase-induced modulation of methotrexate polyglutamylation in murine leukemia L5178Y.
Topics: Animals; Asparaginase; DNA, Neoplasm; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred DBA; Peptides; Polyglutamic Acid; Protein Biosynthesis | 1987 |
Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Survival; Female; Folic Acid Antagonists; Humans; Hydroxylation; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Peptides; Polyglutamic Acid; Rabbits; Tetrahydrofolate Dehydrogenase | 1988 |
Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
Topics: Animals; Cell Division; Cell Survival; Hydrolysis; Leukemia L5178; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains; Polyglutamic Acid; Thymidylate Synthase | 1988 |
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1985 |
Folate requirements of methotrexate-resistant human acute lymphoblastic leukemia cell lines.
Topics: Biological Transport; Cell Line; Drug Resistance; Folic Acid; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Nutritional Requirements; Quinazolines; Trimetrexate | 1986 |
[An experimental attempt to potentiate therapeutic effects of combined use of pulsing magnetic fields and antitumor agents].
Topics: Adenocarcinoma; Animals; Cell Division; Combined Modality Therapy; Cricetinae; DNA, Neoplasm; Electromagnetic Phenomena; Leukemia, Experimental; Magnetic Field Therapy; Male; Methotrexate; Mitomycin; Mitomycins; Neoplasm Transplantation; Pancreatic Neoplasms; Tumor Cells, Cultured | 1988 |
Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Folic Acid; Humans; Leukemia, Experimental; Methotrexate; Ornithine; Peptide Synthases; Rabbits; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Elevation of blood levels of zinc protoporphyrin by radiomimetic drugs and Friend leukemia virus.
Topics: Animals; Antineoplastic Agents; Bone Marrow Transplantation; Cyclophosphamide; Cytarabine; Erythropoiesis; Folic Acid Deficiency; Friend murine leukemia virus; Hydroxyurea; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Porphyrins; Protoporphyrins; Radiation Dosage; Radiation Effects; Whole-Body Irradiation | 1987 |
Murine erythroleukemia cell variants: isolation of cells that have amplified the dihydrofolate reductase gene and retained the ability to be induced to differentiate.
Topics: Animals; Cell Division; Dimethyl Sulfoxide; Drug Resistance; Gene Amplification; Genes; Genetic Variation; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1986 |
Dihydrofolate reductase activity in adriamycin and methotrexate sensitive and resistant P388 leukemia cells.
Topics: Animals; Cell Division; Cell Line; Doxorubicin; Drug Resistance; Folic Acid Antagonists; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1987 |
Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide.
Topics: Animals; Blood Cell Count; Deoxyuridine; Drug Administration Schedule; Drug Synergism; Folic Acid; Leukemia, Experimental; Male; Methotrexate; Nitrous Oxide; Rats; Thymine Nucleotides; Vitamin B 12 | 1986 |
[Therapy of leukemia in rats using a conjugate of specific immunoglobulin and albumin-methotrexate].
Topics: Animals; Antigens, Neoplasm; Histocompatibility Antigens; Immunoglobulin G; Leukemia, Experimental; Methotrexate; Neoplasm Transplantation; Rats; Rats, Inbred Lew; Serum Albumin | 1985 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Mitomycin; Mitomycins; Nitrosourea Compounds; Thioguanine | 1985 |
Cross resistance to esters of methotrexate in a doxorubicin-resistant subline of P388 murine leukemia.
Topics: Animals; Cell Survival; Cells, Cultured; Doxorubicin; Drug Resistance; Esterification; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice | 1985 |
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Guanosine; Leukemia, Experimental; Methotrexate; Mice; Ribonucleosides; Structure-Activity Relationship | 1985 |
Lack of dihydrofolate reductase in human tumor and leukemia cells in vivo.
Topics: Animals; Cattle; Cell Line; Cells, Cultured; Chickens; Humans; Leukemia, Experimental; Liver; Methotrexate; NADP; Neoplasms; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 1985 |
Studies on the effect of antifolics in mouse leukemia.
Topics: Age Factors; Aminopterin; Animals; Antineoplastic Agents; Arylformamidase; Carcinoma, Ehrlich Tumor; Dactinomycin; Drug Resistance; Folic Acid Antagonists; Leukemia, Experimental; Liver; Methotrexate; Mice; Mitosis; Oxidoreductases; Spleen; Tetrahydrofolate Dehydrogenase; Vincristine | 1971 |
Sensitivity of transplantable rat leukemia, DBLA-6, to antitumor agents.
Topics: Alkanesulfonates; Animals; Antineoplastic Agents; Asparaginase; Biphenyl Compounds; Bleomycin; Cell Line; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Leukemia, Experimental; Leukocyte Count; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Transplantation; Nitrosourea Compounds; Rats; Streptococcus; Tosyl Compounds; Vinblastine; Vincristine | 1972 |
Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.
Topics: Animals; Chlorine; Enterococcus faecalis; Esters; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1973 |
Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
Topics: Animals; Antimalarials; Chickens; Enterococcus faecalis; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Liver; Malaria; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Plasmodium berghei; Pteridines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Methotrexate analogs. 4.7-Methyl derivatives of methotrexate and dichloromethotrexate. A new synthesis and some biological studies.
Topics: Animals; Cell Line; Chlorine; Enterococcus faecalis; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Magnetic Resonance Spectroscopy; Methane; Methotrexate; Mice; Spectrophotometry, Ultraviolet | 1974 |
Myeloid leukemia C-1498 as a screen for cancer chemotherapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Busulfan; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasms, Experimental; Prednisone; Pyrazoles; Pyrimidines; Triethylenemelamine; Vinblastine; Vincristine | 1966 |
Sensitivity of human leukemic cells to anti-cancer agents in culture.
Topics: Animals; Antineoplastic Agents; Azauridine; Cells; Cells, Cultured; Chlorambucil; Culture Media; Cyclophosphamide; Cytarabine; Drug Resistance; Floxuridine; Horses; Humans; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Prednisone; Thioguanine; Vincristine | 1974 |
Folic acid metabolism in Rauscher murine leukemia and effect of methotrexate on the blood picture.
Topics: Animals; Folic Acid; Injections, Intravenous; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Methotrexate; Mice; Mice, Inbred BALB C; Plasma; Rauscher Virus; Spleen | 1974 |
Effectiveness of cytosine arabinoside therapy on leukemia (L-1210) of the central nervous system in mice arising during methotrexate treatment.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cytarabine; Leukemia, Experimental; Meninges; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Nerve Tissue; Splenic Neoplasms | 1968 |
[New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms].
Topics: Animals; Carcinoma, Hepatocellular; Cycloserine; Female; Folic Acid; Leukemia, Experimental; Liver; Liver Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Mice; Neoplasms, Experimental; Pyridoxal Phosphate; Rats; Spleen; Tetrahydrofolate Dehydrogenase; Transferases | 1971 |
Effect of in vivo treatment with L-asparaginase on the in vitro uptake and phosphorylation of some antileukemic agents.
Topics: Animals; Antimetabolites; Asparaginase; Biological Transport; Cytarabine; Dose-Response Relationship, Drug; Fluorouracil; Leucine; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Oxidative Phosphorylation; Tetrahydrofolate Dehydrogenase; Time Factors | 1974 |
[Effect of folic acid and methotrexate on the reproduction of the Rauscher leukemia virus].
Topics: Animals; Cells, Cultured; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Embryo, Mammalian; Folic Acid; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Rauscher Virus; Time Factors; Virus Cultivation; Virus Replication | 1974 |
Further evaluation of the antitumor activity of homofolate and its reduced derivatives against methotrexate-insensitive tumors.
Topics: Animals; Antineoplastic Agents; Ascorbic Acid; Carcinoma 256, Walker; Cell Line; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1972 |
Attempts at immunotherapy of 100 patients with acute lymphoid leukemia: some factors influencing results.
Topics: Animals; Bone Marrow Examination; Central Nervous System; Corynebacterium; Cytarabine; Cytotoxicity Tests, Immunologic; Disease Models, Animal; Female; Humans; Immune Sera; Immunotherapy; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Activation; Male; Methotrexate; Mice; Mice, Inbred AKR; Remission, Spontaneous | 1972 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, Animal; Drug Therapy, Combination; Ethylenediamines; Fluorenes; Fluorouracil; Interferon Inducers; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Prednisolone; Thioxanthenes; Vincristine | 1974 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Guanosine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Phosphates; Thymidine; Tritium | 1973 |
Detection of endotoxin in commercial L-asparaginase preparations by complement fixation and separation by chromatography.
Topics: Animals; Asparaginase; Cell Line; Chromatography; Chromatography, Gel; Complement Fixation Tests; Complement System Proteins; Cyclophosphamide; Endotoxins; Escherichia coli; Guinea Pigs; Immunity, Active; Leukemia, Experimental; Lipopolysaccharides; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Skin Tests | 1972 |
Pharmacology of 3,5-diamino-1,24-triazole (guanazole). 1. Antitumor activity of guanazole.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cyclophosphamide; Cytarabine; Depression, Chemical; Female; Hydroxyurea; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Lymphoma, Large B-Cell, Diffuse; Male; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Plasmacytoma; Structure-Activity Relationship; Triazoles | 1972 |
Changes in the pyrimidine deoxynucleoside triphosphate pools of L5178Y cells after their exposure to methotrexate and 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Deoxyribonucleotides; Fluorouracil; Leukemia, Experimental; Methotrexate; Mice; Thymine Nucleotides | 1972 |
Chemotherapeutic effects of compound 593A (NSC-135758) on mouse leukemias and some transplanted animal tumors.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Ascites; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Piperazines; Piperidines; Transplantation, Homologous | 1973 |
Increased life-span in AKR leukemia mice treated with prophylactic chemotherapy.
Topics: Animals; Carmustine; Cyclophosphamide; Evaluation Studies as Topic; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred AKR; Prognosis; Time Factors | 1973 |
Schedule-dependent therapeutic synergism for L-asparaginase and methotrexate in leukemic (L5178Y) mice.
Topics: Animals; Antineoplastic Agents; Asparaginase; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred Strains | 1973 |
Enhancement of the antiproliferative action of 1- -D-arabinofuranosylcytosine by methotrexate in murine leukemic cells (L5178Y).
Topics: Animals; Cell Survival; Cells, Cultured; Clone Cells; Cytarabine; Drug Synergism; Furans; Hypoxanthines; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Phosphates; Serine; Time Factors; Tritium | 1973 |
Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.
Topics: Animals; Cell Line; Chlorobenzenes; Diamines; Folic Acid; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1973 |
Peripheral nucleated cell count as a method of assessing the response of antileukemic agents in Rauscher virus-diseased mice.
Topics: Animals; Antineoplastic Agents; Blood; Busulfan; Carbamates; Cell Count; Chlorambucil; Cyclophosphamide; Dose-Response Relationship, Drug; Ethylamines; Fluorouracil; Lethal Dose 50; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Nitrogen Mustard Compounds; Propylamines; Rauscher Virus; Sulfanilamides | 1973 |
Loading of the reticuloendothelial system: effect on the induction, development and chemotherapy of Rauscher virus leukemia.
Topics: Animals; Gold; Injections, Intraperitoneal; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mononuclear Phagocyte System; Organ Size; Rauscher Virus; Spleen | 1973 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mechlorethamine; Methotrexate; Mice; Neoplasm Transplantation; Prednisone; Procarbazine; Prognosis; Radioisotope Teletherapy; Radiotherapy Dosage; Transplantation, Homologous; Vinblastine; Vincristine | 1974 |
[Leukemia L 5222 of the rat strain BD IX. An ethylnitrosourea-induced monocytic-myeloic transplantable form for cytochemical and chemotherapeutic studies].
Topics: Alkaline Phosphatase; Animals; Cell Transformation, Neoplastic; Cyclophosphamide; Disease Models, Animal; Esterases; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Leukemia, Experimental; Liver; Lymph Nodes; Mercaptopurine; Methotrexate; Neoplasm Transplantation; Nitrosourea Compounds; Peroxidases; Rats; Rats, Inbred Strains; Spleen; Transplantation, Homologous; Vincristine | 1974 |
The immunodepressive activity of N-diazoacetylglycine amide in some transplantation systems.
Topics: Acetates; Amides; Animals; Azathioprine; Azo Compounds; Carcinoma, Ehrlich Tumor; Diazonium Compounds; Female; Glycine; Immunosuppressive Agents; Leukemia, Experimental; Male; Methotrexate; Mice; Neoplasm Transplantation; Skin Transplantation | 1970 |
Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y.
Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Cyclophosphamide; Cytarabine; Cytogenetics; Drug Resistance; Female; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Transplantation, Heterologous; Transplantation, Homologous | 1972 |
Cell proliferation and the differential response of normal and malignant tissues. Silvanus Thompson Memorial Lecture.
Topics: Animals; Blood Vessels; Busulfan; Cell Survival; Cyclophosphamide; Cytarabine; Diffusion; Epithelial Cells; Epithelium; Fibrosarcoma; Hematopoietic Stem Cells; Intestine, Small; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Effects; Rats | 1972 |
Purineless death as a link between growth rate and cytotoxicity by methotrexate.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Hypoxanthines; In Vitro Techniques; Leucine; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1972 |
Loss of resistance to methotrexate in L5178Y mouse leukemia grown in vitro.
Topics: Agar; Animals; Cell Line; Cells, Cultured; Clone Cells; Drug Resistance; In Vitro Techniques; Leukemia, Experimental; Methotrexate; Mice; Mutation; Pharmacogenetics; Tetrahydrofolate Dehydrogenase | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cyclophosphamide; Cytarabine; Cytidine; Dose-Response Relationship, Drug; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Sarcoma 180 | 1972 |
Induction and characteristics of resistance to L-asparaginase (NSC-109229) in mouse leukemia L5178Y.
Topics: Amino Acids; Animals; Asparaginase; Azaserine; Body Weight; Cytarabine; Drug Resistance; Female; Leukemia, Experimental; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; Immunosuppressive Agents; Leukemia, Experimental; Leukemia, Lymphoid; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental | 1971 |
Predictive tests in culture of drug-resistant mutants selected in vivo.
Topics: Animals; Antineoplastic Agents; Biological Assay; Cell Line; Clone Cells; Cytarabine; Drug Resistance; Idoxuridine; Leukemia, Experimental; Methods; Methotrexate; Mice; Mice, Inbred Strains; Molecular Biology; Mutagens; Mutation; Prognosis | 1971 |
Observations on viral, chemical, and radiation-induced myeloid and lymphoid leukemias in RF mice.
Topics: Alkylating Agents; Animals; Estrogens; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Radiation-Induced; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental; Retroviridae; Thymus Neoplasms; Urethane | 1966 |
The use of long-term human leukocyte cell cultures as models for the study of antileukemic agents.
Topics: Animals; Antineoplastic Agents; Burkitt Lymphoma; Culture Techniques; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Mercaptopurine; Methotrexate; Mice; Prednisolone; Vincristine | 1969 |
L-asparaginase induced alteration of amethopterin (methotrexate) activity in mouse leukemia L5178Y.
Topics: Animals; Asparaginase; Asparagine; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Female; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Time Factors; Tritium | 1971 |
Growth rate and cell kill.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Humans; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Cytotoxic mechanisms of folate antagonists.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Culture Media; Folic Acid Antagonists; HeLa Cells; L Cells; Leukemia, Experimental; Methotrexate; Thymine | 1971 |
Active immunotherapy in the treatment of experimental leukemias and acute lymphoblastic leukemia in man.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Animals; BCG Vaccine; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Transfusion; Mercaptopurine; Methotrexate; Mice; Middle Aged; Neoplasm Transplantation; Prednisone; Radiation Effects; Transplantation, Homologous; Vincristine | 1970 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Quinazoline antifolates: dosage schedules and toxicity.
Topics: Aminopterin; Animals; Antineoplastic Agents; Body Weight; Dosage Forms; Folic Acid Antagonists; Leucovorin; Leukemia, Experimental; Male; Methotrexate; Mice; Quinazolines | 1971 |
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparagine; Azaserine; Blood; Cyclophosphamide; Escherichia coli; Fluorouracil; Guinea Pigs; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mitomycins; Prednisone; Vincristine | 1967 |
A comparison of 4-amino-4-deoxy-N10-methylpteroic acid and methotrexate transport by mouse leukemia cells.
Topics: Animals; Biological Transport; Cell Line; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Methotrexate; Nitrogen; Time Factors; Tritium | 1969 |
S-phase cells of rapidly growing and resting populations. Differences in response to methotrexate.
Topics: Animals; Cell Line; Clone Cells; Culture Techniques; Deoxyuridine; DNA; Folic Acid Antagonists; Kinetics; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium | 1969 |
Evidence for two molecular species of dihydrofolate reductase in amethopterin resistant and sensitive cells of the mouse leukemia L4946.
Topics: Animals; Antibodies; Chloromercuribenzoates; Chromatography, Gel; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Molecular Weight; Sodium Chloride; Tetrahydrofolate Dehydrogenase | 1970 |
Treatment of experimental mouse hemoblastosis. VII. Time course of change in the frequency of mitoses of leukaemic leukocytes (L 14 AKR and LaH VUFB) after administration of methotrexate.
Topics: Animals; Body Weight; Leukemia, Experimental; Leukocytes; Liver; Methotrexate; Mice; Mitosis; Organ Size; Spleen; Time Factors | 1970 |
Effects of cytosine arabinoside on the cell viability and uptake of deoxypyrimidine nucleosides in L5178Y cells.
Topics: Animals; Culture Techniques; Cytarabine; Depression, Chemical; DNA, Neoplasm; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Nucleosides; Phosphates; RNA, Neoplasm; Thymidine; Tritium | 1968 |
On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.
Topics: Animals; Deoxyuridine; DNA, Neoplasm; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Transplantation; Nucleosides; Nucleotides; Thymidine | 1968 |
[On resistance to antineoplastic drugs].
Topics: Animals; Antineoplastic Agents; Drug Tolerance; Leukemia; Leukemia, Experimental; Methotrexate; Mice; Sarcoma, Yoshida | 1969 |
Uptake as a determinant of methotrexate response in mouse leukemias.
Topics: Animals; Culture Techniques; Leukemia, Experimental; Methotrexate; Mice; Mortality | 1965 |
The effects of chemotherapy on the kinetics of leukemic cell behavior.
Topics: Animals; Cyclophosphamide; Kinetics; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Nitroso Compounds | 1965 |