methotrexate has been researched along with Encephalopathy, Toxic in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 34 (33.33) | 29.6817 |
| 2010's | 46 (45.10) | 24.3611 |
| 2020's | 22 (21.57) | 2.80 |
| Authors | Studies |
|---|---|
| Batchelor, T; Song, KW | 1 |
| Astorquizaga, L; Cheistwer, A; Font, D; Marin, F; Palmieri, F | 1 |
| Bansal, R; Bhojwani, D; Wayne, AS | 1 |
| Baker, K; Cole, PD; Diglio, F; Li, S; Marshall, G; Patel, C; Wen, J | 1 |
| Dave, M; Feuer, P; Ilahi, Z; Janardhan, S; Khariton, M; Romanos-Sirakis, E; Venkataraman, A | 1 |
| Andión-Catalán, M; García-Salido, A; Lassaleta-Atienza, Á; Leoz-Gordillo, I; López-De Suso, D; Sirvent-Cerdá, S | 1 |
| Kaczmarska, A; Lejman, M; Śliwa-Tytko, P; Zawitkowska, J | 1 |
| Elhasid, R; Levin, D; Manisterski, M; Peled, Y; Shiran, S; Shukrun, R | 1 |
| Kuo, E; Lau, KM; On, S | 1 |
| Calvo, C; Delgado, EF; Ruggeri, RA | 1 |
| Cohen, IJ; Sadeh, M; Toledano, H | 1 |
| Bernhardt, MB; Brown, AL; Gramatges, MM; Harris, RD; Lupo, PJ; Rabin, KR; Schafer, ES; Scheurer, ME; Taylor, OA; Zobeck, MC | 1 |
| Bhojwani, D; Dabagh, S; David, H; Doan, A; Young, S | 1 |
| Fustino, NJ; Juhl, K; Leister, J | 1 |
| Kuhn, AK; Rubin, MF | 1 |
| Fried, M; Krämer, I; Kühn, M; Rosentreter, J | 1 |
| Banerjee, P; Bhakta, N; Brinkman, TM; Chemaitilly, W; Cheung, YT; Ehrhardt, MJ; Green, DM; Huang, IC; Hudson, MM; Hyun, G; Krull, KR; Liu, W; Mulrooney, DA; Ness, KK; Robison, LL; Srivastava, D; Williams, AM | 1 |
| Chan, CH; Kao, WY; Liao, PF; Peng, TR | 1 |
| Haque, AU; Jabbar, N; Mirza, S; Razi, W; Sadiq, H; Ullah, R | 1 |
| Luskin, MR; Manzano, GS; Torre, M; Vaitkevicius, H | 1 |
| Chang, KA; Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC | 1 |
| Cohen, IJ | 5 |
| Akinyede, O; Bhatt, N; Dighe, D; Giordano, L; Iqbal, A | 1 |
| Ameneiros-Lago, E; Fernández-Fernández, FJ; Lijó-Carballeda, C; Sesma, P | 1 |
| Forster, VJ; McDonnell, A; McKay, JA; Theobald, R | 1 |
| Akbaraly, T; Deneux, V; Haouy, S; Leboucq, N; Saumet, L; Sirvent, N | 1 |
| Kanfi, A; Samanta, D; Willis, E | 1 |
| Felice, MS; Guitter, MR; Millan, NC; Monges, MS; Pastrana, A; Zubizarreta, PA | 1 |
| Derwich, K; Jończyk-Potoczna, K; Karmelita-Katulska, K; Pawlak, M; Pilarczyk, J; Przepióra, A; Wachowiak, J; Zając-Spychała, O | 1 |
| Arakawa, Y; Hanada, R; Ikeda, Y; Isobe, K; Koh, K; Mori, M; Oguma, E; Oyama, C; Sasaki, K; Uehara, T; Watanabe, K; Yanagi, M | 1 |
| Chen, J; Ngo, D; Rosenthal, J | 1 |
| Printz, C | 1 |
| Awad, AS; Azab, SS; Menze, ET; Shalaby, YM | 1 |
| Bastos-Oreiro, M; Churruca, J; Diez-Martin, JL; Fernandez-Garcia, P; Guzman-de-Villoria, JA; Oarbeascoa, G; Rodriguez-Macias, G | 1 |
| Aja, PM; Aloke, C; Awoke, JN; Famurewa, AC; Maduagwuna, EK; Nwankwo, OE | 1 |
| Arush, MW; Ash, S; Bonda-Shkedi, E; Cohen, IJ; Goshen, Y; Kaplinsky, C; Yaniv, I | 1 |
| Franco Ospina, L; García Corzo, J; Rueda Arenas, E | 1 |
| de Broucker, T; Henry, C; Jarquin, S; Leclercq, D | 1 |
| Bhojwani, D; Cheng, C; Evans, WE; Howard, SC; Inaba, H; Jeha, S; Khan, RB; Krull, KR; Metzger, ML; Panetta, JC; Pei, D; Pui, CH; Reddick, WE; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sabin, ND; Sandlund, JT; Yang, JJ | 1 |
| Afshar, M; Birnbaum, D; Golden, C | 1 |
| Morgensztern, D; Peddi, PF; Peddi, S; Santos, ES | 1 |
| Escherich, G; Löbel, U; Trah, J | 1 |
| Kinzel, O; Mattle, HP; Verma, RK; Wiest, R | 1 |
| Yoshida, M | 1 |
| Bishop, MW; Brinkman, TM; Cheung, YT; Daryani, VM; Edelmann, MN; Hudson, MM; Kimberg, C; Krull, KR; Liu, W; Mulrooney, DA; Ness, KK; Robison, LL; Srivastava, DK; Stewart, CF | 1 |
| Effinger, KE; Link, MP | 1 |
| Badke, C; Fleming, A; Hijiya, N; Iqbal, A; Khilji, O; Morgan, E; Parhas, S; Weinstein, J | 1 |
| MacEneaney, P; O'Toole, O; Ryan, C; Yap, SM | 1 |
| Ambrosetti, A; Balzarotti, M; Binder, M; Cavalli, F; Cwynarski, K; Deckert, M; Fabbri, A; Ferrari, A; Ferreri, AJ; Finke, J; Fox, CP; Gørløv, JS; Hemmaway, C; Hertenstein, B; Hess, G; Illerhaus, G; Johnson, P; Keller, U; Krause, SW; Levis, A; Linton, KM; Panse, J; Pisani, F; Politi, LS; Ponzoni, M; Pukrop, T; Pulczynski, E; Reni, M; Rosée, PL; Roth, A; Rudà, R; Schmoll, HJ; Schorb, E; Stilgenbauer, S; Torri, V; Tucci, A; Zucca, E | 1 |
| Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW | 2 |
| Cruz, AT; Shah, MD; Shim, YH; Stevens, AM; Subrahmanian, KN; Tran, BH | 1 |
| Ben Youssef, Y; Bouneb, R; Khelif, A; Mahjoub, M; Zaghouani, H; Zahra, K; Zaier, M | 1 |
| Drachtman, RA; Haines, C; Pan, WJ; Rogers, P | 1 |
| Bajwa, RPS; Gerhardt, CA; Hagedoorn, M; Keim, MC; Lehmann, V; Olshefski, RS; Tuinman, MA; Winning, AM | 1 |
| Botturi, A; Bruzzone, MG; Ciceri, E; Erbetta, A; Potepan, P; Salmaggi, A; Sghirlanzoni, A; Silvani, A | 1 |
| Kieffer, S; McKinney, A; Santacruz, K; Tulloch, J | 1 |
| Brugnoletti, F; Inaba, H; Jeha, S; Laningham, FH; Morris, EB; Patay, Z; Pauley, JL; Pui, CH | 1 |
| Ehrlichman, RS; Gandal, MJ; Rudnick, ND; Siegel, SJ | 1 |
| Becker, A; Bode, U; Jaehde, U; Schüsseler, P; Vezmar, S | 1 |
| Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V | 1 |
| Grier, HE; Janeway, KA | 1 |
| Malhotra, A; Welte, FJ | 1 |
| Paudyal, B; Skliut, M; Viets, R | 1 |
| Dürken, M; Karremann, M; Neumaier-Probst, E; von Komorowski, G | 1 |
| Koo, YX; Lai, GG; Lim, ST; Tan, TT; Tao, M | 1 |
| Caceres-Marzal, C; Casado, MS; de Murillo, SG; Gervasini, G; Jimenez, M; Vagace, JM | 1 |
| Froklage, FE; Heimans, JJ; Reijneveld, JC | 1 |
| Cakmakci, H; Gozmen, S; Hiz, S; Irken, G; Karapinar, TH; Oren, H; Tufekci, O; Yilmaz, S | 1 |
| Chaturvedi, A; Ishak, GE; Iyer, RS; Khanna, PC; Pruthi, S | 1 |
| Adly, AA; Darwish, YW; El Aziz, AA; Hassanein, SM; Saeed, OM; Tantawy, AA | 1 |
| Berrueco-Moreno, R; Campistol, J; Cruz-Martinez, O; Fons-Estupina, MC; Garcia-Puig, M; Rives-Sola, S | 1 |
| Avrahami, G; Cohen, IJ; Kornreich, L; Shuper, A; Stark, B; Yaniv, I | 1 |
| Becker, A; Bode, U; Jaehde, U; Vezmar, S | 1 |
| Gottschling, S; Graf, N; Krenn, T; Meyer, S; Reinhard, H; Strowitzki, M | 1 |
| Jayabose, S; Kutscher, M; Sandoval, C; Tenner, M | 1 |
| Chinot, OL; Hoang-Xuan, K; Taillandier, L | 1 |
| Renard, D; Vandenberghe, R; Vandenbussche, E; Westhovens, R | 1 |
| Kim, M; Lee, ST | 1 |
| Jaksic, W; Lewis, I; Pozza, C; Veljkovic, D | 1 |
| Abu Eid, M; Audibert, C; Bernardo, R; Bogorin, A; Botelho, C; Dietemann, JL; Jacques, C; Kremer, S; Nogueira, T; Vargas, MI; Zöllner, G | 1 |
| Chapman, CS; Szawarski, P | 1 |
| Bader, P; Heckl, S; Herrlinger, U; Küker, W; Nägele, T | 1 |
| Baehring, J; Fulbright, R; Gorman, M; Haykin, M; van Hoff, J | 1 |
| Boogerd, W; Hamburger, HL; Kreukels, BP; Ridderinkhof, KR; Schagen, SB; van Dam, FS | 1 |
| Baehring, JM; Fulbright, RK; Gorman, M; Haykin, ME; van Hoff, J | 1 |
| Batchelor, TT; Eichler, AF; Henson, JW | 1 |
| Homma, J; Hondoh, H; Morii, K; Onda, K; Sano, M; Shinbo, Y; Takahashi, H; Tamura, T; Tanaka, R; Tsuchiya, N; Yajima, N; Yamanaka, R | 1 |
| Cole, PD; Drachtman, RA; Drapala, DA; Glod, J; Kamen, BA; Lisi, S; Masterson, M; Smith, AK; Zebala, JA | 1 |
| Klockgether, T; Linnebank, M; Malessa, S; Moskau, S; Pels, H; Schlegel, U; Semmler, A | 1 |
| Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S | 1 |
| Crews, KR; Daw, NC; Inaba, H; Khan, RB; Laningham, FH; Pui, CH | 1 |
| Balin, J; Kujawski, L; Parmar, H | 1 |
| Altaha, R; Harless, W; Price, S; Rikhye, S | 1 |
| Arbizu, J; López de Mesa, R; Narbona, J; Sánchez-Carpintero, R; Sierrasesúmaga, L | 1 |
| Cociglio, M; Hansel, S; Hillaire-Buys, D; Margueritte, G; Peyriere, H; Poiree, M | 1 |
| Marwaha, RK; Ray, M; Trehan, A | 1 |
| Brant, J; Nielsen, E | 1 |
15 review(s) available for methotrexate and Encephalopathy, Toxic
| Article | Year |
|---|---|
Treatment of Primary CNS Lymphoma: Maximizing Clinical Benefit, Minimizing Neurotoxicity.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neurotoxicity Syndromes; Prognosis | 2021 |
Managing therapy-associated neurotoxicity in children with ALL.
Topics: Adolescent; Antibodies, Bispecific; Anticonvulsants; Antineoplastic Agents; Central Nervous System Neoplasms; Disease Management; Female; Glucocorticoids; Humans; Immunotherapy, Adoptive; Leukemia; Male; Methotrexate; Neurotoxicity Syndromes | 2021 |
Methotrexate-induced stroke-like neurotoxicity: Case report, 8 years of experience, and literature review.
Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Neurotoxicity Syndromes; Stroke | 2022 |
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Topics: Asparaginase; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Immunologic Factors; Immunotherapy, Adoptive; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.
Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Neurotoxicity after high-dose methotrexate (MTX) is adequately explained by insufficient folinic acid rescue.
Topics: Antidotes; Antimetabolites, Antineoplastic; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes | 2017 |
Review of dextromethorphan administration in 18 patients with subacute methotrexate central nervous system toxicity.
Topics: Central Nervous System Agents; Child; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; Methotrexate; Neurotoxicity Syndromes; Receptors, N-Methyl-D-Aspartate | 2014 |
Central nervous system toxicities of chemotherapeutic agents.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cisplatin; Cytarabine; Fluorouracil; Humans; Ifosfamide; Methotrexate; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Vidarabine; Vincristine | 2014 |
Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects.
Topics: Antidotes; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cisplatin; Doxorubicin; Hearing Loss; Heart Diseases; Humans; Ifosfamide; Infertility; Kidney Diseases; Methotrexate; Neoplasms, Second Primary; Neurotoxicity Syndromes; Osteosarcoma; Survivors | 2010 |
Central neurotoxicity in cancer chemotherapy: pharmacogenetic insights.
Topics: Antineoplastic Agents; Apolipoproteins E; Blood-Brain Barrier; Central Nervous System Diseases; Humans; Metabolic Networks and Pathways; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Pharmacogenetics; Polymorphism, Genetic | 2011 |
Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Drug Interactions; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2002 |
Biochemical and clinical aspects of methotrexate neurotoxicity.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Brain; Excitatory Amino Acids; Humans; Methotrexate; Neurotoxicity Syndromes; Spinal Cord | 2003 |
Treatment of primary central nervous system lymphoma in the elderly.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dementia; Humans; Lymphoma; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Survival Rate | 2003 |
[Imaging in acute toxic encephalopathy].
Topics: Acute Disease; Alcohol Deterrents; Anticonvulsants; Carbon Monoxide Poisoning; Diagnosis, Differential; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Emergency Treatment; Ethanol; Hazardous Substances; Heavy Metal Poisoning; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methanol; Methotrexate; Myelinolysis, Central Pontine; Neuroradiography; Neurotoxicity Syndromes; Substance-Related Disorders; Wernicke Encephalopathy | 2004 |
Chemotherapy-induced neurotoxicity: assessment and interventions for patients at risk.
Topics: Antineoplastic Agents; Cisplatin; Cytarabine; Humans; Ifosfamide; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Nursing Assessment; Oncology Nursing; Paclitaxel; Vinca Alkaloids | 2002 |
4 trial(s) available for methotrexate and Encephalopathy, Toxic
| Article | Year |
|---|---|
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Comparative Effectiveness Research; Cytarabine; Death, Sudden; Denmark; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Gastrointestinal Diseases; Germany; Heart Injuries; Hematopoietic Stem Cell Transplantation; Humans; Hyperglycemia; Induction Chemotherapy; Infections; Intraocular Lymphoma; Italy; Kaplan-Meier Estimate; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mucositis; Neurotoxicity Syndromes; Neutropenia; Optic Nerve Neoplasms; Poisoning; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Stroke; Switzerland; Thiotepa; Thrombocytopenia; Thrombosis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; United Kingdom | 2016 |
Salvage therapy and late neurotoxicity in patients with recurrent primary CNS lymphoma treated with a modified ProMACE-MOPP hybrid regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lymphoma; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neurotoxicity Syndromes; Prednisone; Procarbazine; Retrospective Studies; Salvage Therapy; Survival Analysis; Vincristine | 2007 |
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.
Topics: Adolescent; Aminopterin; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Child; Child, Preschool; Drug Overdose; Erythrocytes; Female; Fever; Folic Acid Antagonists; Gastrointestinal Diseases; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome | 2008 |
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors | 2007 |
83 other study(ies) available for methotrexate and Encephalopathy, Toxic
| Article | Year |
|---|---|
[Methotrexate-induced stroke-like syndrome: A pediatric case report].
Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2021 |
Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate.
Topics: Age Factors; Animals; Antimetabolites, Antineoplastic; Apoptosis; Behavior, Animal; Cancer Survivors; Cognitive Dysfunction; Disease Models, Animal; Female; Male; Methotrexate; Microglia; Neurogenesis; Neurotoxicity Syndromes; Rats; Rats, Long-Evans; Sex Factors; Time Factors | 2022 |
Ketamine as an Adjunct for Treatment of Methotrexate-induced Neurotoxicity.
Topics: Child; Homocysteine; Humans; Ketamine; Methotrexate; Neurotoxicity Syndromes; Paresis | 2022 |
Prevalence and management of methotrexate-induced neurotoxicity in pediatric patients with osteosarcoma: a single-center experience.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Prevalence; Retrospective Studies; Young Adult | 2022 |
Neurotoxicity with blinatumomab in combination with intrathecal methotrexate therapy.
Topics: Antibodies, Bispecific; Humans; Methotrexate; Neurotoxicity Syndromes | 2023 |
Subacute methotrexate neurotoxicity in patients with oncohematological disease. A report of 3 cases.
Topics: Antimetabolites, Antineoplastic; Humans; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Creatinine; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2023 |
Severe, Fatal Methotrexate-related Neurotoxicity in 2 Adolescent Patients With ALL.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Severity of Illness Index; Young Adult | 2020 |
Dextromethorphan Administration on Day 0 and Day 7 for Secondary Prevention of Methotrexate-induced Neurotoxicity in Childhood Acute Lymphoblastic Leukemia: A Retrospective Case Series.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Secondary Prevention; Young Adult | 2021 |
Management of methotrexate-induced neurotoxicity with aminophylline plus dextromethorphan in a pediatric patient with pineoblastoma.
Topics: Adolescent; Aminophylline; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Bronchodilator Agents; Cisplatin; Cyclophosphamide; Dextromethorphan; Disease Management; Drug Therapy, Combination; Etoposide; Excitatory Amino Acid Antagonists; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Pineal Gland; Pinealoma; Prognosis | 2020 |
Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an osteosarcoma patient.
Topics: Adolescent; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Interactions; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Piperacillin; Renal Insufficiency | 2021 |
Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood.
Topics: Adult; Antimetabolites, Antineoplastic; Cancer Survivors; Cardiovascular Diseases; Chronic Disease; Cognitive Dysfunction; Cranial Irradiation; Endocrine System Diseases; Humans; Injections, Spinal; Logistic Models; Mental Status and Dementia Tests; Methotrexate; Nervous System Diseases; Neurocognitive Disorders; Neurosurgical Procedures; Neurotoxicity Syndromes; Odds Ratio; Radiation Injuries; Respiratory Tract Diseases | 2021 |
High-Dose Aminophylline for Methotrexate-Induced Neurotoxicity in a Patient With Brain Metastasis.
Topics: Aminophylline; Brain; Brain Neoplasms; Humans; Methotrexate; Neurotoxicity Syndromes | 2021 |
Safety and Efficacy of Aminophylline in Intrathecal Methotrexate-related Neurological Toxicity in Large Pediatric Oncology Centre.
Topics: Aminophylline; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness, and Encephalopathy.
Topics: Antimetabolites, Antineoplastic; Clinical Reasoning; Confusion; Diplopia; Dysarthria; Female; Humans; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Muscle Weakness; Neurotoxicity Syndromes; Sleepiness | 2021 |
Methotrexate Neurotoxicity Is Related to Epigenetic Modification of the Myelination Process.
Topics: Animals; Antimetabolites, Antineoplastic; Brain; Brain-Derived Neurotrophic Factor; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Injections, Intraperitoneal; Injections, Spinal; Male; Methotrexate; Myelin Sheath; Neurotoxicity Syndromes; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; SOXE Transcription Factors | 2021 |
Lack of neurotoxicity after rapid clearance of high dose methotrexate followed by minimal dose folinic acid.
Topics: Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes | 2022 |
Methotrexate-Induced Neurotoxicity in Hispanic Adolescents with High-Risk Acute Leukemia-A Case Series.
Topics: Acute Disease; Adolescent; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Female; Hispanic or Latino; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Methotrexate; Neurotoxicity Syndromes; Risk Factors; Young Adult | 2017 |
Dextromethorphan and Methylxanthines Might Be Useful in the Treatment of Methotrexate-Induced Neurotoxicity.
Topics: Dextromethorphan; Humans; Methotrexate; Neurotoxicity Syndromes; Xanthines | 2017 |
Effect of methotrexate/vitamin B
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Methylation; Humans; Long Interspersed Nucleotide Elements; Methotrexate; Neurons; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tacrolimus Binding Proteins; Vitamin B 12 | 2017 |
[Acute methotrexate-related neurotoxicity and pseudo-stroke syndrome].
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Child; Diagnosis, Differential; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Syndrome | 2017 |
A Not Uncommon Cause of Stroke Mimicker in Children.
Topics: Adolescent; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2018 |
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Polyneuropathies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Sinus Thrombosis, Intracranial; Treatment Outcome; Vincristine; Vocal Cord Paralysis | 2018 |
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Cancer Survivors; Case-Control Studies; Chemoradiotherapy; Child; Cognition Disorders; Cranial Irradiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Organ Size; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Treatment Outcome; Young Adult | 2018 |
Characteristics of methotrexate-induced stroke-like neurotoxicity.
Topics: Antimetabolites, Antineoplastic; Blood Coagulation; Blood Coagulation Tests; Child; Child, Preschool; Diagnosis, Differential; Female; Hematologic Neoplasms; Humans; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Retrospective Studies; Stroke | 2018 |
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease.
Topics: Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Cytarabine; Humans; Hydrocortisone; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2019 |
Neurotoxicity more likely in Hispanic children treated for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Hispanic or Latino; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2019 |
Involvement of Nrf2/HO-1 antioxidant signaling and NF-κB inflammatory response in the potential protective effects of vincamine against methotrexate-induced nephrotoxicity in rats: cross talk between nephrotoxicity and neurotoxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Kidney; Locomotion; Male; Maze Learning; Methotrexate; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vincamine | 2019 |
Methotrexate-Induced Subacute Neurotoxicity Surrounding an Ommaya Reservoir in a Patient with Lymphoma.
Topics: Antimetabolites, Antineoplastic; Catheters, Indwelling; Diagnosis, Differential; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Neurotoxicity Syndromes; Paresis; Young Adult | 2019 |
Moringa oleifera seed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of oxidative stress and neuro-inflammation in rats.
Topics: Animals; Antineoplastic Agents; Coconut Oil; Cytokines; Dietary Supplements; Glutathione; Humans; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Moringa oleifera; Neurotoxicity Syndromes; Nitric Oxide; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Seeds; Superoxide Dismutase | 2019 |
The correlation between dose of folinic acid and neurotoxicity in children and adolescents treated for osteosarcoma with high-dose methotrexate (HDMTX): a neuropsychological and psychosocial study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Male; Methotrexate; Neuropsychological Tests; Neurotoxicity Syndromes; Osteosarcoma; Young Adult | 2013 |
[Hemiparesis and facial palsy caused by methotrexate].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Facial Paralysis; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Paresis | 2013 |
Acute leukoencephalopathy due to pyrimethamine. An insight into methotrexate neurotoxicity?
Topics: Antiprotozoal Agents; Brain; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Pyrimethamine; Retinitis; Young Adult | 2013 |
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Leucovorin; Leukoencephalopathies; Logistic Models; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors | 2014 |
Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia.
Topics: Analgesics, Non-Narcotic; Child; Female; Humans; Immunosuppressive Agents; Injections, Spinal; Intracranial Hemorrhages; Methotrexate; Neurotoxicity Syndromes; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography | 2015 |
Toxic cerebellar syndrome due to methotrexate.
Topics: Cerebellum; Deglutition Disorders; Dysarthria; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Neurotoxicity Syndromes | 2015 |
[Central nervous system neurotoxicity of anticancer chemotherapy].
Topics: Antineoplastic Agents; Central Nervous System; Humans; Leukoencephalopathy, Progressive Multifocal; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome | 2015 |
Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma.
Topics: Adult; Antimetabolites, Antineoplastic; Attention; Bone Neoplasms; Case-Control Studies; Cognition; Cognition Disorders; Cross-Sectional Studies; Emotions; Executive Function; Female; Humans; Male; Memory; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Osteosarcoma; Quality of Life; Risk Assessment; Risk Factors; Survivors; Time Factors; Treatment Outcome; United States | 2016 |
For Patients With Cancer, Cure Is Not Enough.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cognition; Cognition Disorders; Female; Hospitalization; Humans; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Osteosarcoma; Survivors | 2016 |
Rechallenging With Intrathecal Methotrexate After Developing Subacute Neurotoxicity in Children With Hematologic Malignancies.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Consolidation Chemotherapy; Female; Hematologic Neoplasms; Humans; Induction Chemotherapy; Injections, Spinal; Maintenance Chemotherapy; Male; Methotrexate; Neurotoxicity Syndromes; Retrospective Studies; Young Adult | 2016 |
Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Apraxias; Brain; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Humans; Leukemia; Methionine; Methotrexate; Myelin Sheath; Neurotoxicity Syndromes; Nitrous Oxide; Nutritional Status; Seizures; Vitamin B 12 Deficiency | 2016 |
Evaluation and Management of Acute-Onset Hemiparesis in an Adolescent With Leukemia.
Topics: Adolescent; Antidotes; Antimetabolites, Antineoplastic; Brain; Diffusion Magnetic Resonance Imaging; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
Acute methotrexate neurotoxicity revealed by a cerebellar syndrome.
Topics: Antimetabolites, Antineoplastic; Cerebellar Diseases; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Syndrome | 2016 |
Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect?
Topics: Drug Interactions; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes | 2017 |
A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.
Topics: Adolescent; Antimetabolites, Antineoplastic; Combined Modality Therapy; Dextromethorphan; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Facial Paralysis; Female; Humans; Lower Extremity; Methotrexate; Muscle Hypotonia; Muscle Weakness; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Upper Extremity | 2017 |
Psychosexual development and satisfaction in long-term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Case-Control Studies; Cranial Irradiation; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Lymphoma; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Orgasm; Personal Satisfaction; Psychosexual Development; Reproductive Health; Risk Factors; Sexual Partners; Surveys and Questionnaires; Survivors; Thiotepa; Young Adult | 2017 |
Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect.
Topics: Drug Interactions; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes | 2017 |
Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments.
Topics: Adult; Aged; Antineoplastic Agents; Asparaginase; Brain; Cerebral Veins; Child; Cyclosporine; Diagnosis, Differential; Female; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Paraneoplastic Syndromes, Nervous System; Radiotherapy; Risk Factors; Venous Thrombosis | 2008 |
A 50-year-old man with burkitt lymphoma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Axons; Brain; Brain Edema; Burkitt Lymphoma; Coma; Delirium; Fatal Outcome; Humans; Iatrogenic Disease; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Nerve Fibers, Myelinated; Neurotoxicity Syndromes | 2008 |
Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings.
Topics: Adolescent; Diffusion; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Speech Disorders | 2009 |
A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Auditory Perception; Cognition Disorders; Electroencephalography; Electrophysiology; Evoked Potentials; Evoked Potentials, Auditory; Fear; Fluorouracil; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Recognition, Psychology | 2008 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult | 2009 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Methotrexate-related neurotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes | 2010 |
A case of low-dose oral methotrexate-induced reversible neurotoxicity.
Topics: Administration, Oral; Diffusion Magnetic Resonance Imaging; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Neurotoxicity Syndromes | 2010 |
[Hemiparesis in acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Cytarabine; Diffusion Magnetic Resonance Imaging; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Injections, Spinal; Methotrexate; Neurologic Examination; Neurotoxicity Syndromes; Paresis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Central Nervous System Neoplasms; Drug Administration Schedule; Female; Fever; Fungemia; Humans; Immunocompromised Host; Immunosuppressive Agents; Lupus Nephritis; Lymphoma; Methotrexate; Mycophenolic Acid; Neurotoxicity Syndromes; Neutropenia; Rituximab; Treatment Outcome; Young Adult | 2011 |
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.
Topics: Antimetabolites, Antineoplastic; Child, Preschool; Female; Folic Acid; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
A rare complication of intrathecal methotrexate in a child with acute lymphoblastic leukemia.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Child; Dexamethasone; Female; Humans; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Time Factors; Vitamin B Complex | 2011 |
Medication neurotoxicity in children.
Topics: Adolescent; Angiogenesis Inhibitors; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Child, Preschool; Cyclosporine; Female; Humans; Immunosuppressive Agents; Infant; Magnetic Resonance Imaging; Male; Methotrexate; Metronidazole; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Tacrolimus; Young Adult | 2011 |
Somatosensory evoked potential for detection of subclinical neuropathy in Egyptian children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Computer Simulation; Egypt; Electrodes; Electrophysiology; Evoked Potentials, Somatosensory; Female; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk | 2010 |
[Neurotoxicity due to methotrexate in paediatric patients. Description of the clinical symptoms and neuroimaging findings].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Neuroimaging; Neurotoxicity Syndromes; Retrospective Studies | 2012 |
Severe encephalopathy caused by intraparenchymal methotrexate instillation due to the design of the catheter.
Topics: Brain Neoplasms; Catheterization; Child, Preschool; Equipment Failure; Humans; Injections, Intraventricular; Magnetic Resonance Imaging; Male; Medulloblastoma; Methotrexate; Neurotoxicity Syndromes; Primary Prevention; Risk Assessment; Severity of Illness Index | 2003 |
Neurotoxicity of intrathecal methotrexate: MR imaging findings.
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
Reversible posterior leucoencephalopathy during oral treatment with methotrexate.
Topics: Alexia, Pure; Antirheumatic Agents; Arthritis, Psoriatic; Drug Administration Routes; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Humans; Magnetic Resonance Imaging; Memory Disorders; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Occipital Lobe; Perceptual Disorders; Recovery of Function; Vision Disorders; Visual Perception | 2004 |
Diffusion-weighted MRIs in an acute leukoencephalopathy following intrathecal chemotherapy.
Topics: Acute Disease; Adult; Antineoplastic Agents; Brain Edema; Diffusion Magnetic Resonance Imaging; Humans; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes | 2004 |
Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid.
Topics: Adult; Aminophylline; Brain Diseases; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2004 |
A woman who couldn't speak: report of methotrexate neurotoxicity.
Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Speech Disorders | 2005 |
Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Diffusion Magnetic Resonance Imaging; Humans; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome | 2005 |
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Diffusion Magnetic Resonance Imaging; Edema; Female; Humans; Leukemia, B-Cell; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Retrospective Studies | 2006 |
Electrophysiological correlates of information processing in breast-cancer patients treated with adjuvant chemotherapy.
Topics: Adult; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; Chemotherapy, Adjuvant; Cognition Disorders; Cyclophosphamide; Electroencephalography; Evoked Potentials; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neuropsychological Tests; Neurotoxicity Syndromes; Reaction Time | 2005 |
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Diffusion Magnetic Resonance Imaging; Edema; Female; Humans; Leukemia, B-Cell; Leukemia, Lymphoid; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Retrospective Studies | 2006 |
Prevention of high-dose-methotrexate neurotoxicity by adequate folinic acid rescue is possible even after central nervous system irradiation.
Topics: Antineoplastic Agents; Central Nervous System; Dose-Response Relationship, Drug; Folic Acid; Humans; Methotrexate; Models, Biological; Neurotoxicity Syndromes; Risk Factors | 2007 |
Diffusion and perfusion imaging in subacute neurotoxicity following high-dose intravenous methotrexate.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Tomography, X-Ray Computed | 2007 |
Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acute Disease; Adult; Alleles; Antimetabolites, Antineoplastic; Brain; Burkitt Lymphoma; Female; Homozygote; Humans; Magnetic Resonance Imaging; Methotrexate; Mutation; Neurotoxicity Syndromes | 2007 |
Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer.
Topics: Acute Disease; Adolescent; Aminophylline; Antimetabolites, Antineoplastic; Bone Neoplasms; Brain; Child; Diffusion Magnetic Resonance Imaging; Female; Histiocytoma, Malignant Fibrous; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Metabolic Clearance Rate; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2008 |
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.
Topics: Adult; Brain Diseases; Diffusion Magnetic Resonance Imaging; Humans; Immunosuppressive Agents; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
A fatal outcome in a patient with glioblastoma multiforme after receiving high-dose methotrexate.
Topics: Adult; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Glioblastoma; Hernia; Humans; Intracranial Pressure; Methotrexate; Neurotoxicity Syndromes | 2008 |
Transient posterior encephalopathy induced by chemotherapy in children.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Cyclophosphamide; Dactinomycin; Female; Humans; Hypertension; Magnesium Deficiency; Male; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Radiopharmaceuticals; Remission Induction; Syndrome; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2001 |
Reversal of neurologic disturbances related to high-dose methotrexate by aminophylline.
Topics: Aminophylline; Antimetabolites, Antineoplastic; Child; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency | 2001 |
Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Dexamethasone; Fatal Outcome; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2002 |