Page last updated: 2024-08-25

methotrexate and Disease Models, Animal

methotrexate has been researched along with Disease Models, Animal in 358 studies

Research

Studies (358)

Timeframe	Studies, this research(%)	All Research%
pre-1990	66 (18.44)	18.7374
1990's	29 (8.10)	18.2507
2000's	61 (17.04)	29.6817
2010's	157 (43.85)	24.3611
2020's	45 (12.57)	2.80

Authors

Authors	Studies
Brattsand, R; Fyfe, M; Graffner-Nordberg, M; Hallberg, A; Mellgård, B	1
Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T	1
Al-Shamma, H; Barden, J; Buzard, DJ; Calderon, I; Chen, C; Edwards, J; Espinola, S; Fu, L; Gao, Y; Gatlin, J; Gharbaoui, T; Han, S; Jones, RM; Kawasaki, A; Krishnan, A; Le, M; Lehmann, J; Liu, L; Lopez, L; Moody, J; Morgan, M; Sadeque, A; Sengupta, D; Solomon, M; Thatte, J; Thoresen, L; Ullman, B; Usmani, K; Whelan, K; Xing, C; Zhu, X	1
Bailey-Downs, LC; Gangjee, A; Ihnat, MA; Namjoshi, OA; Thorpe, JE; Yu, J	1
Alonso-Castro, AJ; Campos-Xolalpa, N; Hernández-Munive, A; Pérez-González, C; Pérez-Gutiérrez, S; Zapata-Morales, JR	1
Bhide, RS; Carter, PH; Davies, P; Dhar, TG; Goldstine, CB; Gu, X; Neels, J; Pedicord, DL; Poss, MA; Qin, LY; Ruan, Z; Ruepp, S; Sack, JS; Salter-Cid, LM; Skala, S; Stachura, S; Stefanski, K; Weigelt, C; Xie, JH	1
Cai, HD; Chen, ZH; Fang, MH; Huang, HH; Su, YP; Xu, Y; Yang, J; Yu, CX; Zeng, YL	1
Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S	1
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Clausen, MH; Peiró Cadahía, J; Petrovic, K; Previtali, V; Troelsen, NS	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Artigas, A; Blanch, L; Bringué, J; Camprubí-Rimblas, M; Guillamat-Prats, R; Martinez, ML; Torrents, E	1
Abdel-Moneim, AM; Alfwuaires, M; Alzahrani, AM; Elsawy, H; Khalil, M	1
Ahmed-Farid, OA; Bakeer, RM; Hashad, IM; Mansour, DF; Rady, M; Saleh, DO	1
Aranarochana, A; Chaisawang, P; Naewla, S; Pannangrong, W; Sirichoat, A; Sritawan, N; Suwannakot, K; Welbat, JU; Wigmore, P	1
Li, S; Shi, J; Tang, H	1
Fukuo, Y; Futamura, G; Hiramatsu, R; Hu, N; Kashiwagi, H; Kawabata, S; Miyatake, SI; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M; Watanabe, T; Yoshimura, K	1
Abd El-Aal, SA; Arab, HH; Arafa, EA; Ashour, AM; Eid, AH; Mahmoud, AM	1
Baker, K; Cole, PD; Diglio, F; Li, S; Marshall, G; Patel, C; Wen, J	1
Aldossary, SA; Chohan, MS; Mohaini, MA; Tasleem Rasool, S	1
Aoki, Y; Bouvet, M; Hamada, K; Han, Q; Hoffman, RM; Kubota, Y; Masaki, N; Nishida, K; Tome, Y; Yamamoto, J	1
Alqahtani, SS; Alshahrani, S; Banji, D; Banji, OJF; Rashida, S	1
Agostini, SBN; Alves, CO; Bernardes, MTCP; Carvalho, FC; da Silva, LP; Gonçalves, RV; Novaes, RD; Pereira, GR	1
Amada, N; Futamura, T; Kakumoto, Y; Maeda, K	1
Kim, HJ; Kim, MA; Lee, CM; Lee, JS; Shin, SR	1
Acharya, AP; Mangal, JL; Suresh, AP; Swaminathan, SJ; Thumsi, A	1
Ikeda, Y; Kajiyama, H; Niimi, K; Nishiko, Y; Nishino, K; Oda, Y; Shibata, M; Shimizu, Y; Tamauchi, S; Yamamoto, E; Yasui, Y; Yokoi, A; Yoshida, K; Yoshihara, M; Yoshikawa, N	1
Bahramizadeh, M; Esmaily, H; Golmohammadzadeh, S; Hatamipour, M; Jafari, MR; Jafarian, AH; Kiafar, B; Moosavian, SA; Nikpoor, AR; Rezaeemehr, Z	1
Aggarwal, G; Chandra, A; Manchanda, S; Narula, A	1
Akturan, S; Cimen, FK; Kurt, N; Malkoc, İ; Mammadov, R; Suleyman, B; Suleyman, Z	1
Chen, YC; Hsiao, CC; Hsu, MH; Huang, LT; Sheen, JM; Wang, SC	1
Du, H; Lan, J; Li, Y; Liu, P; Tao, J; Zhang, L; Zhu, J	1
Alexander, T; Allen, AR; Anderson, JE; Groves, T; Kiffer, F; McElroy, T; Trujillo, M	1
Akdis, CA; Boyman, O; Hafner, J; Impellizzieri, D; Kolios, AGA; Kurzbach, D; Nguyen, TT; Nilsson, J; Özcan, A; Sahin, D; Tan, G; Yawalkar, N	1
Bai, T; Dai, X; Guo, Z; Li, Y; Lu, Q; Tian, X; Yao, J; Zhang, Y; Zhong, Y	1
Furukawa, H; Higuchi, T; Mizuno, S; Naito, T; Oka, S; Ono, M; Takahashi, S; Tanaka, K; Tohma, S; Tsuchiya, N; Warabi, E; Yoshimura, M; Yuhara, S	1
Li, H; Li, X; Liu, J; Luo, S; Wan, Z; Wang, Y; Wu, X; Xie, X; Yang, M; Zhao, Z	1
Abdelazem, AZ; Abdelaziz, RM; Attia, YA; Hashem, KS	1
Berlin, C; Hopland, K; Lange, K; Lekaye, HC; Phillips, S; Piao, J; Tabar, V	1
Bai, J; Fan, X; Hu, J; Hu, M; Li, Y; Sun, Y; Wang, B; Xu, Y; Zhao, S	1
Abd-Elhalem, SS; Abu-El Magd, EE; El Zawawy, WK; El-Shinnawy, NA; Haggag, NZ	1
Muhammad, N; Rizvi, SAA; Saleh, AM; Shahzad, Y	1
Abdel-Moneim, AM; Alfwuaires, M; Algefare, AI; Elmenshawy, OM; Elsawy, H; Khalil, M; Sedky, A	1
Aldhahrani, A; Alkhedaide, A; Althobaiti, F; Mohamed, WA; Nassan, MA; Soliman, MM	1
Gao, Y; Huang, B; Jin, X; Liang, X; Liu, Y; Lv, J; Ma, J; Tang, K; Tong, W; Wang, J; Wang, X; Xie, J; Xu, P; Yao, F; Zhang, H; Zhang, Y; Zhou, N	1
Chaisawang, P; Pannangrong, W; Prajit, R; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P	1
Abdel-Wahab, BA; Ali, FEM; Alkahtani, SA; Alshabi, AM; Hassanein, EHM; Mahnashi, MH	1
Chen, Y; Dai, Z; Han, L; Huang, RY; Liang, CL; Liu, H; Lu, C; Qiu, F; Yan, Y; Zhang, Q	1
Hamaue, N; Hirafuji, M; Iizuka, K; Kikuchi, K; Machida, T; Minami, M	1
Ayhan, A; Benkhoff, M; Dannenberg, L; Helten, C; Huhn-Wientgen, R; Ignatov, D; Kelm, M; Levkau, B; M'Pembele, R; Mourikis, P; Petzold, T; Polzin, A; Sarabhai, T; Trojovsky, K; Zako, S; Zeus, T	1
Bergamo, M; Häfeli, UO; Nosrati, Z; Rodríguez-Rodríguez, C; Saatchi, K	1
Fu, G; Gu, X; Hou, J; Liu, X; Shi, C; Sun, Y; Tian, J; Wu, J; Yu, B; Zhang, M; Zhang, R; Zheng, Y	1
Anger-Góra, N; Goszczyński, TM; Mierzejewska, J; Pajtasz-Piasecka, E; Rossowska, J; Świtalska, M; Szczygieł, A; Węgierek-Ciura, K	1
Abdelhamid Ibrahim, SS; Ali, MA; El-Sayyad, SM; Kandil, LS; Ragab, GM	1
Agrawal, S; Gamian, A; Hamar, P; Krawczyk, M; Krenács, T; Makuch, S; Pastuch-Gawołek, G; Szeja, W; Szkudlarek, D; Wiśniewski, J; Woźniak, M	1
Akselim, B; Gulaboglu, M; Kiremitli, S; Kiremitli, T; Mammadov, R; Tor, IH; Yazici, GN; Yilmaz, B	1
Gao, J; Han, J; Liu, S; Liu, Y; Ma, D; Su, Y; Tian, M; Wei, C; Xu, K; Zhang, G; Zhang, L	1
Asenso, J; Sun, W; Tang, H; Wang, B; Wang, C; Wang, Y; Wei, X; Wu, Y; Xiao, F	1
Aslan, K; Azizoglu, ZB; Deniz, K; Erdem, S; Haliloglu, Y; Karakukcu, M; Patiroglu, T; Per, S; Suna, PA; Tasdemir, A; Unal, E; Yay, AH; Yilmaz, E	1
Arpag, H; Atilla, N; Aydemir, Y; Cakir, T; Gül, M; Polat, C; Sayan, M; Yiğitcan, B; Þehirli, Ö	1
Alim, MA; Bird, G; Haleagrahara, N; Hayes, L; Ketheesan, N; Miranda-Hernandez, S	1
Barbieri, LR; Carvalho, PO; Gutierrez, PS; Lourenço-Filho, DD; Maranhão, RC; Stolf, NAG; Tavares, ER	1
Han, Y; Hu, S; Sun, W; Wang, L; Wang, Q; Wang, R; Wang, X; Wei, W; Wu, L; Wu, Y; Zhang, L; Zhang, M	1
Fruman, DA; Khaw, A; Konopleva, M; Lee, JS; Lu, M; Lui, B; Mallya, S; Müschen, M; Nguyen, D; Pandori, W; Vo, TT	1
Abbasi, MM; Abdal, K; Abdollahi, B; Aghbali, AA; Fotohi, S; Hamishehkar, H; Khiavi, MM; Salehi, R; Sina, M	1
Obmińska-Mrukowicz, B; Suszko, A	1
Badinter, F; Benhar, I; Goltsman, H; Krispel, S; Liran, A; Miari, R; Neil, GA; Panet, A; Shapir, N; Shatil, T; Sherbo, S; Tal, O; Zafir-Lavie, I	1
Hao, J; Hou, Y; Lin, C; Qian, K; Setrerrahmane, S; Wu, Q; Wu, X; Xu, H; Yu, L	1
Cheng, X; Lee, RJ; Li, Y; Liu, J; Sun, F; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M	1
Boucau, MC; Forsberg, MM; Gosselet, F; Gynther, M; Ihalainen, J; Kanninen, KM; Koistinaho, J; Malm, T; Picardat, T; Ruponen, M; Vellonen, KS; White, AR	1
Panonnummal, R; Sabitha, M	1
Dolatshahi, M; Esmaeilizadeh, M; Goudarzi, M; Hosseinzadeh, A; Khadem Haghighian, H; Mehrzadi, S; Nesari, A; Safaei, F	1
Ferguson, PJ; Girschick, HJ; Hedrich, CM; Hofmann, SR; Kapplusch, F; Morbach, H; Pablik, J	1
Berman, H; Binns, MA; Henkelman, M; Nguyen, M; Piquette-Miller, M; Sekeres, MJ; Tannock, IF; van Eede, M; Winocur, G; Wojtowicz, JM; Yu, J; Zhang, H	1
Al-Melhim, WN; Fouad, AA	1
Fuller, S; Ghanbari, HA; Jiang, ZG; Shevtsova, O; Winocur, G; Wojtowicz, JM	1
Brownfoot, F; Campbell, L; Ellett, L; Hannan, NJ; Hastie, R; Horne, AW; Kaitu'u-Lino, TJ; Lim, E; Sluka, P; Tong, S	1
Bonazzi, A; Caselli, G; Colovic, M; Comi, E; Di Luccio, E; Ferioli, C; Ferrari, F; Giambelli, R; Lanza, M; Letari, O; Maggioni, D; Mennuni, L; Perrella, M; Persiani, S; Piepoli, T; Rovati, LC; Zanelli, T; Zerbi, S	1
Bakhshayesh, M; Goudarzi, M; Kalantari, H; Malayeri, AR; Mehrabani, M; Mehrzadi, S	1
Epete, MA; Famurewa, AC; Folawiyo, AM; Igwe, EC; Maduagwuna, EK; Okike, PI	1
Zhang, H; Zhao, G	1
Carvalho, PO; Gomes, FLT; Hatab, SA; Higuchi, ML; Kalil-Filho, R; Maranhão, RC; Mattos, FR; Pitta, FG; Serrano, CV; Tavares, ER	1
Benko, M; Bismuth, G; Blüml, S; Burkard, TR; Cavaco-Paulo, A; Charvet, C; Feuillet, V; Fischer, MB; Huppa, JB; Lager, F; Le Roux, D; Leksa, V; Machacek, C; Matsuyama, T; Mitulovic, G; Ohradanova-Repic, A; Platzer, R; Renault, G; Stockinger, H; Suchanek, M; Zlabinger, GJ	1
Brands, R; Chandrupatla, DMSH; Elshof, E; Hammond, A; Jansen, G; Lammertsma, AA; Low, PS; Matsuyama, T; Molthoff, CFM; Musters, RJP; Ritsema, WIGR; van der Laken, CJ; Vos, R; Windhorst, AD	1
Allez, M; Bitoun, S; Dönnes, P; Florence, K; Gleizes, A; Hacein-Bey-Abina, S; Hincelin-Mery, A; Krzysiek, R; Le Grand, R; Ly, B; Mackay, F; Mariette, X; Nocturne, G; Pallardy, M; Paoletti, A; Pascaud, J; Pruvost, A; Roques, P	1
Al-Anazi, KM; Allam, AA; Farah, MA; Germoush, MO; Mahmoud, AH; Mahmoud, AM	1
Bai, D; Chen, S; Fan, Y; Huang, R; Lu, L; Shu, Y; Tian, Y; Wang, P; Wang, Y; Wu, L; Xia, X; Xu, H; Yang, L; Yu, C; Yuan, F; Zhang, R; Zhang, S; Zhang, X; Zhou, B	1
Giacomelli, R; Ruscitti, P; Shoenfeld, Y	1
Barres, BA; Geraghty, AC; Gibson, EM; Goldstein, AK; Greene, JJ; Liddelow, S; Monje, M; Nagaraja, S; Ni, L; Ocampo, A; Pallegar, PN; Tam, LT; Vogel, H; Woo, PJ; Wood, LS	1
Akatli, AN; Huz, M; Ozhan, O; Pamukcu, E; Parlakpinar, H; Samdanci, ET; Tanbek, K	1
Chen, L; Duan, L; Fan, J; Guo, M; Hu, G; Huang, Q; Jin, Y; Li, Y; Liao, T; Liao, X; Liu, B; Liu, S; Lv, Z; Tang, K; Tao, X; Wang, X; Wu, F; Xu, J; Xu, P; Yang, G; Zhang, S; Zhou, M	1
Guo, R; Ke, S; Lin, M; Su, Z; Zeng, D	1
Di, T; Li, N; Li, P; Li, X; Liu, Z; Meng, Y; Wang, M; Xie, X; Zhai, C; Zhang, L	1
Ridker, PM	1
Azzoni, P; Benassi, L; Bessar, H; Bianchi, L; Botti, E; Casagrande, V; Costanzo, A; Federici, M; Fratoddi, I; Magnoni, C; Pellacani, G; Samir, MA; Vaschieri, C; Venditti, I	1
Afroz, S; Khan, RA; Siddiqui, DE	1
Feng, L; Guo, M; Huang, W; Kong, L; Shao, F; Song, P; Wu, X; Xu, F; Xu, L; Xu, Q	1
Fawzy, HM; Gad, AM; Kamel, KM; Mansour, SM; Safar, MM	1
Becker, ML; Funk, RS; Kiptoo, P; Siahaan, TJ; Singh, RK; van Haandel, L	1
Gao, Y; Ge, W; Lu, W; Sun, Q; Xu, X; Yang, X; Yang, Y; Zhang, J; Zhao, Y	1
Geraghty, AC; Ghanem, RA; Gibson, EM; Goldstein, AK; Greenberg, ME; Greene, JJ; Longo, FM; Marton, RM; Monje, M; Ni, L; Ocampo, A; Paşca, SP; Yang, T	1
Farombi, EO; Ochaoga, SE; Odunola, OA; Owumi, SE	1
Bolok, Y; Brunengraber, H; Hoppe, G; McCollum, L; Sears, JE; Sharma, A; Singh, C; Song, W; Tran, V	1
Kuyucu, Y; Ozcan, AA; Ozgun, H; Ozkan, EB; Polat, S; Sekeroglu, HT	1
Cabezas-Herrera, J; Fernández-Pérez, MP; Montenegro, MF; Piñero-Madrona, A; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-del-Campo, L	1
Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA	1
Guan, T; Guan, Z; Li, G; Niu, B; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhu, Z	1
Deng, ZB; Dryden, G; Guo, H; Jiang, H; Miller, D; Mu, J; Wang, B; Wang, Q; Xiang, X; Yan, J; Zhang, HG; Zhang, L; Zhuang, X	1
Chen, W; Herrero, LJ; Mahalingam, S; Rulli, NE; Sheng, KC; Taylor, A	1
Jie, J; Liu, Z; Tian, B; Yang, Y; Zhang, X; Zhou, M	1
Ahmed, RS; Arora, VK; Banerjee, BD; Subramaneyaan, M; Tripathi, AK; Yasmeen, S	1
Garg, T; Goyal, AK; Parnami, N; Rath, G	1
Bateman, E; Bowen, J; Greenberg, N; Keefe, D; Mayo, B; Plews, E; Schiffrin, E; Stringer, A; Wignall, A	1
Aziz, M; Belmonte, L; Beutheu, S; Bôle-Feysot, C; Coëffier, M; Déchelotte, P; Galas, L; Guérin, C; Ouelaa, W; Tennoune, N	1
Gupta, A; Singh, S	1
Abraham, P; Isaac, B; Kolli, VK; Natarajan, K; Selvakumar, D	1
Aksun, S; Cetin, ES; Dirican, A; Dirican, N; Kalemci, S; Karacam, V; Sözen, H; Sütcü, R; Ulger, E; Uner, AG; Yaylali, A	1
Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z	1
Cavalcanti, SC; Corrêa, L; Luz, JG; Mello, SB	1
Choi, K; Choi, SJ; Kim, HS; Kim, K; Kwon, IC; Lee, A; Park, K; Seo, DH; Yoon, SY; Youn, I	1
DuHadaway, JB; Gilmour, S; Mandik-Nayak, L; Muller, AJ; Pigott, E; Prendergast, GC	1
Anumol, T; Canet, MJ; Cherrington, NJ; Clarke, JD; Goedken, MJ; Hardwick, RN; Lake, AD; Merrell, MD; Snyder, SA; Street, SM	1
Akbulut, S; Dogan, Z; Elbe, H; Erdemli, E; Eris, C; Otan, E; Toprak, G; Turkoz, Y	1
Cherrington, NJ; Coen, M; Goedken, MJ; Hardwick, RN; Holmes, E; Jin, Z; Kyriakides, M	1
Jost-Brinkmann, PG; Meyer, P; Minden, K; Präger, TM; Radlanski, RJ; Rafayelyan, S	1
Aslan, MK; Atasoy, P; Boybeyi, Ö; Gunal, YD; Kısa, U	1
Chang, G; Li, Q; Lin, Y; Pang, T; Wang, C; Wang, J; Xu, H; Zhang, H	1
Berkowitz, D; Coran, AG; Geyer, T; Mogilner, JG; Pollak, Y; Sukhotnik, I	1
Amano, W; Kimoto, Y; Matsuo, A; Matsushita, M; Noji, S; Nozawa, K; Ogawa, Y; Oki, C; Shinozaki, Y; Shiozaki, M; Tanimoto, A	1
Abbasi, MM; Hamishehkar, H; Jahanban-Esfahlan, R; Monfaredan, A	1
Chai, AP; Mao, RR; Xu, L; Yang, YX; Yu, CL; Zhou, H	1
Biswas, S; Nandakumar, K; Patel, A; Ramalingayya, GV; Shoja, MH	1
Brito, GA; Cavalcanti, Pde F; de Araújo, AA; de Araújo, RF; de Medeiros, CA; de Moura Freire, MA; Freire, MA; Reinaldo, MP	1
Abd Elhalem, SS; Darwish, AS; Shehata, IH; Wahba, SM	1
Bako, F; Banfalvi, G; Kertai, P; Nagy, G; Trencsenyi, G	1
Dabak, DO; Kocaman, N	1
Alponti, RF; Mendes, MT; Silveira, PF; Yamasaki, SC	1
Capitano, M; Hylander, BL; Kokolus, KM; Lee, CT; Leigh, ND; Repasky, EA	1
Chen, Y; Dong, Y; Guan, Z; Niu, B; Niu, Y; Wang, J; Wang, X; Zhang, T	1
Armagan, HH; Armagan, I; Bayram, D; Candan, IA; Celik, E; Uğuz, AC; Yigit, A	1
Araújo, TE; Borba, PB; da Silva, AI; de Araújo Júnior, RF; de Araújo, AA; de Souza, FH; Nogueira, AC; Saldanha, TS	1
Altenberger, S; Dao Trong, ML; Gottschalk, O; Jansson, V; Metz, P; Mutschler, W; Schmitt-Sody, M	1
Bae, SC; Bae, YS; Choi, CB; Choi, JH; Jang, J; Kang, MS; Lee, HS; Park, JE; Seong, YR; Woo, YJ	1
Ahmed, W; Nabil, T; Zaki, A	1
Groen, AK; Havinga, R; Kuiken, NS; Rings, EH; Tissing, WJ	1
Guo, GL; Schumacher, JD	1
Chen, L; Liu, W; Shen, Z; Wang, C; Yan, J; Yang, H; Yang, J; Zhai, Z	1
Ho Kim, J; Hun Park, S; Hyun Min, B; Ju Kim, B; Keun Han, D; Kim, DY; Kim, K; Reum Son, A; Suk Kim, M; Yong Jang, J; Yun Yin, X	1
Boechat, AL; da Costa, AG; de Oliveira, CP; Guterres, SS; Malheiro, A; Pohlmann, AR; Tarragô, AM	1
Bao, J; Chemaitilly, W; Frase, S; Green, DM; Janke, L; Lynch, J; Morgan, JA; Opferman, JT; Panetta, JC; Schuetz, JD; Wang, Y; Zheng, J	1
Deleuran, B; Hauge, EM; Hetland, ML; Hvid, M; Hørslev-Petersen, K; Jalilian, B; Junker, P; Keller, KK; Kragstrup, TW; Laustsen, JK; Stengaard-Pedersen, K; Vorup-Jensen, T; Zhang, X; Østergaard, M	1
Bonfá, E; Guido, MC; Maranhão, RC; Mello, SB; Tavares, ER	1
Battastini, AM; Bergamin, LS; de Oliveira, CP; Figueiró, F; Guterres, SS; Jandrey, EH; Mendes, FB; Moritz, CE; Pettenuzzo, LF; Pohlmann, AR; Rockenbach, L; Sévigny, J	1
Gao, HF; Li, LF; Liu, ZH; Shen, T; Shi, CJ; Wen, XS; Xian, CJ; Xu, XK	1
Baykal, B; Elbey, B; Keskin, I; Kuş, S; Şahin, A; Yazgan, ÜC; Yılmaz, A	1
Cavaco-Paulo, A; Gomes, A; Nogueira, E; Preto, A	1
Altruda, F; Del Carmen Dominguez, M; Lorenzo, N; Silengo, L	1
Al-Rjoub, MF; Augsburger, JJ; Banerjee, RK; Correa, ZM; Manna, S	1
Armua-Fernandez, MT; Deplazes, P; Eichenberger, RM; Joekel, D; Matsumoto, J; Schweiger, A	1
Merkley, CM; Tannock, IF; Winocur, G; Wojtowicz, JM	1
Burcu, B; Kanter, M; Karabacak, R; Orhon, ZN; Yarali, O	1
Garg, NK; Katare, OP; Sharma, G; Singh, B; Tyagi, RK	1
Abd El-Twab, SM; Hozayen, WG; Hussein, OE; Mahmoud, AM	1
Bauerová, K; Bezáková, L; Bilka, F; Čavojský, T; Harmatha, J; Hrádková, I; Kuncírová, V; Mihálová, D; Nosáľ, R; Pašková, Ľ; Paulíková, I; Poništ, S; Šišková, K	1
Chen, S; Hou, J; Liu, Q; Wang, Y; Xing, J; Yu, B; Zhang, H; Zhang, R; Zhao, Q	1
Chang, F; Chen, X; Ding, J; Feng, X; Gao, Z; Wang, Y; Yang, M; Zhuang, X	1
Abulsamad, K; Adams, SL; Dobrzanski, MJ; Hylind, JC; Reome, JB; Rewers-Felkins, KA	1
Jena, GB; Pawar, AA; Ramarao, P; Tripathi, DN; Vikram, A	1
Draenert, FG; Draenert, K	1
Ishih, A; Kino, H; Muregi, FW	1
Bashenko, Y; Ben Lulu, S; Coran, AG; Mogilner, JG; Shamian, B; Shaoul, R; Shteinberg, D; Sukhotnik, I; Ure, BM	1
Coran, AG; Karry, R; Lurie, M; Mogilner, JG; Shaoul, R; Shteinberg, D; Sukhotnik, I; Ure, BM	1
Buwalda, B; Coppens, CM; Koolhaas, JM; Schagen, SB; Seigers, R; van Dam, FS; van der Most, PJ	1
Garssen, J; Hartog, A; Hulsman, J	1
Huysentruyt, LC; Seyfried, TN; Shelton, LM	1
Kawai, J; Nagate, T; Nakayama, J	1
Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Uysal, B	1
Howarth, GS; Sundar, S; Tran, CD	1
Butler, RN; Howarth, GS; Lymn, KA; Tooley, KL	1
Bauerová, K; Jurcovicová, J; Rovenský, J; Stancíková, M; Svík, K; Utesený, J	1
Ding, Y; Gao, Y; Li, A; Liu, J; Lv, X; Sun, H; Zhang, Z; Zhao, P	1
Erwig, LP; Savage, CO	1
Isik, A; Koca, SS; Ozercan, IH; Ozgen, M	1
Cole, PD; Gulinello, M; Li, Y; Vijayanathan, V	1
Hübner, C; Kern, P; Kocherscheidt, L; Pichler, BJ; Schmid, A; Soboslay, PT; Wehrl, H; Wiehr, S	1
Goyal, AK; Kesarla, R; Murthy, RR; Nagle, A	1
Kremer, J; Krishnaswami, S; Riese, RJ	1
Chen, M; Kallenberg, CG	1
Fukuwaka, S; Kobayashi, Y; Kohyama, N; Ohbayashi, M; Suzuki, M; Yamamoto, T; Yashiro, Y; Yasuda, M	1
Augsburger, JJ; Banerjee, RK; Correa, ZM; Krishnamoorthy, M; Palakurthi, NK	1
Kawane, K; Kitahara, Y; Nagata, S; Shimaoka, S; Tanaka, H	1
Ambrozova, G; Bauerova, K; Ciz, M; Harmatha, J; Jancinova, V; Lojek, A; Mihalova, D; Nosal, R; Perecko, T	1
Bauerova, K; Boldyrev, A; Drafi, F; Hrabarova, E; Juranek, I; Mihalova, D; Ponist, S; Soltes, L; Valachova, K	1
Byun, YS; Chung, SK	1
Cool, JC; Fan, CM; Foster, BK; Georgiou, KR; King, TJ; Scherer, MA; Xian, CJ	1
Fan, C; Georgiou, KR; King, TJ; Xian, CJ	1
Bole-Feysot, C; Boukhettala, N; Breuillé, D; Coëffier, M; Coquerel, Q; Déchelotte, P; Fetissov, SO; Sinno, MH; Terashi, M	1
Baker, JR; Dunham, T; Majoros, IJ; Ward, BB	1
Banji, D; Banji, OJ; Hayath, MS; Pinnapureddy, J; Saidulu, A	1
Binns, MA; Tannock, I; Winocur, G	1
Ali, N; Cole, PD; Gulinello, M; Vijayanathan, V	1
Asl, NA; Asvadi, A; Asvadi, I; Hajipour, B; Khodadadi, A; Roshangar, L	1
Aguilar, D; Alpizar-Rodríguez, D; Cruz-Robles, D; Escobar-Hernández, S; Férez-Blando, K; Furuzawa-Carballeda, J; Galindo-Feria, AS; Llorente, L; Macip-Rodríguez, P; Soto-Abraham, V	1
Bulut, H; Calişkan, M; Kilinç, K; Sanli, AM; Sargon, MF; Sekerci, Z; Serbes, G	1
Cavalcanti, SC; Corrêa, L; Luz, JG	1
Binns, MA; Henkelman, M; Tannock, IF; Winocur, G; Wojtowicz, JM; Zhang, H	1
Hashizume, M; Matsumoto, I; Mihara, M; Sumida, T; Suzuki, M; Tanaka, K; Yoshida, H	1
Acin, F; Bleda, S; De Haro, J; Esparza, L	1
Baharav, E; Bar, M; Gil-Ad, I; Karp, L; Taler, M; Weinberger, A; Weizman, A	1
Baek, SH; Hong, KW; Kim, CD; Kim, HY; Lee, CW; Lee, SW; Park, SY	1
Beyer, C; Dees, C; Distler, A; Distler, JH; Distler, O; Gelse, K; Khodzhigorova, A; Lang, V; Schett, G; Schneider, H	1
Bhatia, M; Garg, LN; Gupta, S; Kumar, S	1
Chuan-Ying, Y; Lei, Z	1
Ahmad, B; Hashmi, FK; Hussain, K; Islam, M; Muhammad, K; Saleem, U; Tipu, MK	1
Bejar, D; Coran, AG; Mogilner, JG; Nativ, O; Roitburt, A; Sukhotnik, I	1
Ichagichu, M; Karanja, SM; Kariuki, T; Kokwaro, G; Ngotho, M; Nzila, A; Ozwara, H	1
Borea, PA; Corciulo, C; Gessi, S; Giacuzzo, S; Govoni, M; Merighi, S; Padovan, M; Targa, M; Varani, K; Vincenzi, F	1
Dalmarco, EM; Fröde, TS; Medeiros, YS	1
Achira, M; Kume, T; Totsuka, R	1
Balow, JE; Langford, CA	1
Alladi, A; Gupta, DK; Gupta, SD	1
Istok, R; Rovensky, J; Stancíková, M; Svík, K	1
Kimura, H; Kita, E; Konishi, M; Mikasa, K; Narita, N; Takahashi, K; Yoshimoto, E	1
Goto, T; Magari, K; Miyata, S; Mutoh, S; Nishigaki, F; Ohkubo, Y	1
Gause, A; Schnabel, A	1
Choi, S; Haber, M; Liem, NL; Lock, RB; MacKenzie, KL; Milross, CG; Norris, MD; Papa, RA; Ramirez, CD; Rice, AM; Schmid, MA; Tajbakhsh, M	1
Araujo, DH; Brito, GA; Carneiro-Filho, BA; Carvalho, GH; Cavalcante, MC; Lima, AA; Lima, IP; Lima, V; Monteiro, SM; Ribeiro, RA; Santos, FN	1
Akabane, H; Komai, M; Masuda, T; Nagai, H; Nagao, K; Tanaka, H	1
Artym, J; Zimecki, M	1
M'Rabet, L; van Beek, NM; van den Berg, JJ; van't Land, B	1
Fiehn, C; Freudenberg-Konrad, S; Funk, J; Gay, S; Ho, AD; Krienke, S; Müller-Ladner, U; Sinn, H; Wunder, A	1
Boehmer, LN; John, J; Siegel, JM; Wu, MF	1
Mahmood, U; Müller-Ladner, U; Tung, CH; Weissleder, R; Wunder, A	1
Bajtner, E; Holmdahl, R; Lange, F; Nandakumar, KS; Rintisch, C; Sack, U	1
Bush, K; Life, P; Morgan, R; Patten, C; Rioja, I; Trill, J; Wooley, P	1
Butler, RN; Davidson, GP; Howarth, GS; Pelton, NS; Tivey, DR	1
Kakinuma, C; Kuwayama, C; Naba, H; Ogihara, T; Ohnishi, S	1
Chen, LJ; Cheng, XY; Han, YQ; Sun, XJ; Zhao, GF	1
Baker, JR; Balogh, LP; Candido, KA; Cao, Z; Khan, MK; Kukowska-Latallo, JF; Majoros, IJ; Nigavekar, SS; Thomas, TP	1
Balthasar, JP; Lobo, ED	1
Cronstein, BN; D'Eustachio, P; Delano, DL; Desai, A; Fernandez, P; Montesinos, MC; Wilder, T; Wiltshire, T	1
Moreland, LW; Teng, GG; Turkiewicz, AM	1
Blatnik, AF; Brausi, M; Hickey, DP; Soloway, MS	1
Avci, A; Cetin, R; Devrim, E; Durak, I; Ergüder, BI; Kiliçoğlu, B	1
Cuzzocrea, S; Di Paola, R; Mirshafiey, A; Saadat, F	1
Gardner, J; Gonen, M; Heaney, M; O'Connor, OA; Sirotnak, F; Smith, EA; Teruya-Feldstein, J; Toner, LE; Vrhovac, R	1
Hioki, Y; Kusuzaki, K; Matsumine, A; Seto, M; Sonoda, J; Tomoda, R; Uchida, A	1
Deng, SX; Edward, DP; Fiscella, R; Goldstein, DA; Gupta, S; Penland, S; Tessler, HH	1
Angelov, L; Diglaw, T; Fazio, V; Franic, L; Granata, T; Hallene, K; Hernandez, N; Janigro, D; Marchi, N; Masaryk, T; Najm, I	1
D'Argenio, G; Di Marzo, V; Gianfrani, C; Grandone, I; Mazzarella, G; Nigam, S; Petrosino, S; Scaglione, G; Sorrentini, I; Valenti, M	1
Akabas, MH; Cabelof, DC; Goldman, ID; Jansen, M; Malhotra, U; Matherly, LH; Min, SH; Qiu, A; Tsai, E; Zhao, R	1
Guchelaar, HJ; Huizinga, TW; Wessels, JA	1
Garman, R; Housman, M; Joseph, A; Munroe, K; Richards, S	1
Jansson, L; Karlsson, A; Karlsson, L; Melgar, S; Michaëlsson, E; Rehnström, E; Utkovic, H	1
Chung, H; Hong, I; Kang, KS; Kim, HL; Kim, JH; Kim, M; Kong, G; Lee, BH; Lee, MH; Lee, MO; Yoon, BI	1
Ryan, SJ; Sorgente, N; Sunalp, M; Wiedemann, P	1
Lo, GS; Longenecker, JB	1
Blatnik, A; Matheny, RB; Niell, HB; Soloway, MS	1
Drago, JR; Palmer, J	1
Ariyan, S; Goldberg, NH; Kraft, RL	1
Chang, BK; Gutman, R	1
Lamm, DL; Livingston, RB; Stogdill, BJ	1
Bottiglieri, T; Hyland, K; Reynolds, EH	1
Devineni, D; Gallo, JM; Klein-Szanto, A	1
Adachi, M; Gonokami, Y; Kobayashi, H; Konno, S	1
Howes, A; Kernan, WJ; Mullenix, PJ; Sallan, SE; Schunior, A; Tarbell, NJ; Waber, DP	1
Faenza, S; Fini, M; Giardino, R; Giavaresi, G; Martini, L; Morrone, G; Spighi, M	1
Camilleri, JP; Williams, AS; Williams, BD	1
Cronstein, BN; Naime, D; Ostad, E	1
Gaetje, R; Lierse, W; Popp, LW; Status, S	1
Das, PK; Sarkar, HS; Sett, R	1
Breimer, DD; Danhof, M; de Boer, AG; de Lange, EC; de Vries, JD; Zurcher, C	1
Dunkley, PR; Francis, JL; Noltorp, RS; O'Loughlin, EV; Warden, RA	1
Dayan, M; Mozes, E; Segal, R	1
Mihara, M; Moriya, Y; Takagi, N; Takeda, Y; Urakawa, K	1
Neidel, J; Schroers, B; Sintermann, F	1
Aronson, J; Jarka, DE; Nicholas, RW	1
Dayan, M; Mozes, E; Nezlin, R; Zinger, H	1
Fukui, H; Yamamoto, M	1
Amos, N; Goodfellow, RM; Jones, SG; Williams, AS; Williams, BD	1
Joussen, AM; Kirchhof, B; Kruse, FE; Völcker, HE	1
Domb, AJ; Shikani, AH	1
DeLeo, JA; Hashizume, H; Rutkowski, MD; Weinstein, JN	1
Burger, D; Dayer, JM; Edwards , CK; Feige, U	1
Bittner, C; Feyerabend, T; Peters, SO; Raap, M; Remmert, S; Robins, IH; Sieg, P; Sommer, K; Wiedemann, GJ	1
Fujimura, A; Kasahara, K; Kobayashi, E; Nagai, H; Sugimoto, K; To, H; Uchida, H; Xiu, D	1
Alarcón, GS; Arani, R; Baggott, JE; Bernreuter, WK; Gay, RE; Morgan, SL	1
Akamatsu, K; Kawamura, A; Mihara, M; Takagi, N; Takeda, Y; Urakawa, K	1
Frerichs, J; Hoijer, M; Jager, D; Koetsier, M; M'Rabet, L; Meijer, HP; Smeets, RL; van't Land, B	1
Chan, ES; Cronstein, BN	1
Bocaccino, CA; Greenberger, JS; Moloney, WC; Szot, SJ	1
Walker, MD; Weiss, HD	1
Thierfelder, S	1
Dorick, DM; Moccio, DM; Sirotnak, FM	1
Conge, G	1
Dicke, KA; Hendriks, W; Peters, L; Spitzer, G; Stevens, EE	1
Siddall, RA	1
Hasegawa, H; Posner, JB; Shapiro, WR	1
Chemik, NL; Posner, JB; Shapiro, WR; Ushio, Y; Young, DF	1
Bartocci, A; Bonmassar, E; Frati, L; Riccardi, C	1
Forbes, RD; Guttmann, RD; Klassen, J; Knaack, J; Kuramochi, T	1
McCullough, JL; Weinstein, GD	1
Madden, JW	1
Bergsagel, DE; Librach, SL; Ogawa, M	1
Kaufmann, M; Mattern, J; Volm, M; Wayss, K	1
Ezeamuzie, IC; Njoku, AC	1
Broadwater, JR; Jensen, JC; Klimberg, VS; Lang, NP; Nwokedi, E; Pappas, AA; Westbrook, KC	1
Baggott, JE; Freeberg, LE; Gay, RE; Gay, S; Gopal Nair, M; Hudson, BB; Koopman, WJ; Krumdieck, CL; Morgan, SL; Vaughn, WH	1
Barr-Nea, L; Sandovsky-Losica, H; Segal, E	1
Bethouart, M; Buchet-Bouverne, B; Crépin, G; Lecuru, F; Querleu, D; Vasquez, G	1
Bale, G; Chesney, TM; Noah, PW; Rosenberg, EW; Skinner, RB; Xu, B	1
Belitsky, P; Blair, AH; Ghose, T; Kralovec, J; Singh, M	1
Fleischhauer, D; Gassmann, W; Loeffler, H; Mueller-Ruchholtz, W; Uharek, L; Wottge, HU	1
Ladiges, WC; Storb, R; Thomas, ED	1
Mitchell, IC; Turk, JL	1
Niell, HB; Soloway, MS; Wood, CA	1
Kerwar, SS; Oronsky, AL	1
Okeda, R; Shibutani, M	1
D'Angio, G; Davidson, TL; Levine, JD; Micalizzi, M; Packer, RJ; Yanovski, JA	1
Abernathey, CD; Kooistra, KL; Laws, ER; Wilcox, GL	1
Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R	1
Galivan, J; Kerwar, SS; Oronsky, AL; Rath, N; Ridge, SC; Zabriske, J	1
Beidler, DE; Dillman, RO; Johnson, DE; Koziol, JA; Myers, LJ; Shawler, DL; Sweet, MD; Tudor, SD	1
Ben-Nun, A; Cohen, IR; Przuntek, H; Vohl, ML; Wekerle, H; Westarp, ME	1
Chick, BF; Grace, J; Harker, GJ; Stephens, FO; Wass, J; Zbroja, RA	1
Bretscher, P; O'Callaghan, JW; Russell, AS	1
Drago, JR; Lombard, J	1
Anderson, C	1
Glynn, JP; Goldberg, AI; Goldin, A; Kende, M; Mantel, N	1
Husberg, BS	1
Sindram, PJ; Snow, GB	1
Carnegie, PR; Coates, AS; Mackay, IR	1
Kline, I	1
Ericson, U; Lockner, D	1
Berenbaum, MC; Bundick, RV; Reittie, JR; Sheard, CE	1
Shapiro, WR	2
Hoshino, T; Wilson, CB	1
Hreshchyshyn, MM; Kawai, N	1
Husk, M; Mount, BM; Thelmo, WL	1
Husk, M; Mount, BM	1
Cheeks, JB; Laster, WR; Schabel, FM; Skipper, HE; Trader, MW	1
Amiel, JL; De Vassal, F; Hayat, M; Jasmin, C; Mathé, G; Pouillart, P; Rappaport, H; Rosenfeld, C; Schneider, M; Schwarzenberg, L; Weiner, R	1
Bleyer, WA; Yancey, ST	1
Boesen, EA	1
Hansen, HH	1
Ivankovic, S; Zeller, WJ	1
Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS	1
DiMartino, MJ; Misher, A; Walz, DT	1
Ritterson, AL	1
Zubrod, CG	1
Holland, JF	1
De Vita, VT; Kies, MW; Lisak, RP; Vogel, CL	1
Mount, BM; Stevens, LC; Whitmore, WF	1
Ausman, JI; Rall, DP; Shapiro, WR	1
Brockman, RW; Lloyd, HH; Mellett, LB; Montgomery, JA; Schabel, FM; Skipper, HE; Wilkoff, LJ	1
Aoki, T; Hreshchyshyn, MM; Koide, Y	1
Edwards, AJ; Hurd, CM; Rowland, GF; Sumner, MR	1

Reviews

27 review(s) available for methotrexate and Disease Models, Animal

Article	Year
Animal models of drug-induced pulmonary fibrosis: an overview of molecular mechanisms and characteristics. Cell biology and toxicology, 2022, Volume: 38, Issue:5 Topics: Amiodarone; Animals; Bleomycin; Disease Models, Animal; Idiopathic Pulmonary Fibrosis; Lung; Lung Diseases, Interstitial; Methotrexate	2022
Dose Issues in Cancer Chemotherapy. Oncology, 2020, Volume: 98, Issue:8 Topics: Adolescent; Adult; Animals; Antimetabolites, Antineoplastic; Child; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Neoplasms	2020
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. Current osteoporosis reports, 2017, Volume: 15, Issue:6 Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Chemokine CCL2; Chemokine CCL4; Chemokine CCL5; Chemokines; Cytokines; Diphosphonates; Disease Models, Animal; Humans; Immunosuppressive Agents; Inflammasomes; Interleukin-12; Interleukin-6; Methotrexate; Mice; Mitogen-Activated Protein Kinases; Monocytes; Osteomyelitis; Receptors, Interleukin-2; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2017
A comprehensive review on adult onset Still's disease. Journal of autoimmunity, 2018, Volume: 93 Topics: Adaptive Immunity; Adrenal Cortex Hormones; Age of Onset; Animals; Arthritis; Biomarkers; Blood Sedimentation; C-Reactive Protein; Disease Models, Animal; Ferritins; Humans; Immunity, Innate; Macrophage Activation Syndrome; Methotrexate; Still's Disease, Adult-Onset; Survival Analysis; Young Adult	2018
Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis Circulation research, 2019, Volume: 124, Issue:3 Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; CD40 Antigens; CD40 Ligand; Diabetes Mellitus, Type 2; Disease Models, Animal; Hematopoiesis; Humans; Inflammasomes; Interleukin-18; Interleukin-1beta; Interleukin-6; Methotrexate; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Signal Transduction; Stroke; Thrombosis; Triggering Receptor Expressed on Myeloid Cells-1	2019
Mechanistic review of drug-induced steatohepatitis. Toxicology and applied pharmacology, 2015, Nov-15, Volume: 289, Issue:1 Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid	2015
Update on Therapeutic Approaches for Rheumatoid Arthritis. Current medicinal chemistry, 2016, Volume: 23, Issue:21 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Disease Models, Animal; Humans; Methotrexate; Pain Management; Synovial Membrane; T-Lymphocytes	2016
ANCA-associated vasculitides: advances in pathophysiology and treatment. The Netherlands journal of medicine, 2010, Volume: 68, Issue:2 Topics: Animals; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Azathioprine; Cyclophosphamide; Disease Models, Animal; Disease Progression; Humans; Immunoglobulin G; Immunosuppressive Agents; Methotrexate; Mycophenolic Acid	2010
Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes. Best practice & research. Clinical rheumatology, 2010, Volume: 24, Issue:4 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Health Status; Humans; Janus Kinase 3; Methotrexate; Piperidines; Pyrimidines; Pyrroles; Severity of Illness Index; Treatment Outcome	2010
ANCA-associated vasculitides--advances in pathogenesis and treatment. Nature reviews. Rheumatology, 2010, Volume: 6, Issue:11 Topics: Animals; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Monoclonal, Murine-Derived; Cyclophosphamide; Disease Models, Animal; Glucocorticoids; Humans; Methotrexate; Mice; Remission Induction; Rituximab	2010
Methotrexate toxicity in growing long bones of young rats: a model for studying cancer chemotherapy-induced bone growth defects in children. Journal of biomedicine & biotechnology, 2011, Volume: 2011 Topics: Animals; Antineoplastic Agents; Bone Development; Bone Diseases; Child; Disease Models, Animal; Humans; Methotrexate; Neoplasms; Rats	2011
New insights into the immunopathogenesis and treatment of small vessel vasculitis of the kidney. Current opinion in nephrology and hypertension, 2003, Volume: 12, Issue:3 Topics: Adjuvants, Immunologic; Animals; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Cyclophosphamide; Disease Models, Animal; Humans; Kidney; Kidney Diseases; Methotrexate; Mice; Mycophenolic Acid; Rituximab; Vasculitis	2003
[Rheumatology 2003-part I: research news concerning pathogenesis, epidemiology, diagnosis, and therapy of chronic inflammatory joint diseases]. Medizinische Klinik (Munich, Germany : 1983), 2003, Sep-15, Volume: 98, Issue:9 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cells, Cultured; Clinical Trials as Topic; Diagnosis, Differential; Disease Models, Animal; Female; HLA Antigens; Humans; Infliximab; Methotrexate; Middle Aged; Placebos; Polymorphism, Genetic; Pregnancy; Prognosis; Quality of Life; Randomized Controlled Trials as Topic; Rats; Spondylarthropathies; Spondylitis, Ankylosing; Time Factors	2003
[Effect of methotrexate on the immune response in selected experimental models]. Postepy higieny i medycyny doswiadczalnej (Online), 2004, Apr-20, Volume: 58 Topics: Animals; Antibody Formation; Apoptosis; Autoimmune Diseases; Cell Cycle; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Folic Acid Antagonists; Hematopoiesis; Humans; Immunity, Cellular; Immunosuppressive Agents; Methotrexate	2004
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:3 Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome	2008
The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs, 1994, Volume: 48, Issue:2 Topics: AIDS Dementia Complex; Animals; Brain Diseases; Dementia; Disease Models, Animal; Epilepsy; Humans; Metabolism, Inborn Errors; Methotrexate; Methylation; Multiple Sclerosis; Neurotransmitter Agents; Parkinson Disease; Receptors, Neurotransmitter; S-Adenosylmethionine; Spinal Cord Diseases	1994
Anti-interleukin-1 therapy in rheumatic diseases. Current opinion in rheumatology, 2001, Volume: 13, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Disease Models, Animal; Drug Therapy, Combination; Genetic Therapy; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Methotrexate; Sialoglycoproteins; Treatment Outcome	2001
Molecular action of methotrexate in inflammatory diseases. Arthritis research, 2002, Volume: 4, Issue:4 Topics: Adenosine; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Methotrexate; Receptors, Purinergic P1	2002
Chemotherapy in the treatment of malignant brain tumors. Advances in neurology, 1975, Volume: 13 Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Nitrogen Mustard Compounds; Nitrosourea Compounds; Plicamycin; Podophyllotoxin; Procarbazine; Vincristine	1975
Experimental bone marrow transplantation. Blut, 1975, Volume: 30, Issue:1 Topics: Anemia, Aplastic; Animals; Antilymphocyte Serum; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Chick Embryo; Cyclophosphamide; Disease Models, Animal; Dogs; Graft vs Host Reaction; Haplorhini; Histocompatibility Antigens; Humans; Immunization, Passive; Methotrexate; Mice; Mice, Inbred Strains; Rabbits; Radiation Injuries, Experimental; Rats; T-Lymphocytes; Tissue Donors; Transfusion Reaction; Transplantation, Homologous	1975
Cytokinetics and chemotherapy of psoriasis. The Journal of investigative dermatology, 1976, Volume: 67, Issue:1 Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Administration Schedule; Humans; Kinetics; Methotrexate; Mice; Mice, Nude; Psoriasis; Skin Absorption	1976
Plastic surgery and burns. Surgery, gynecology & obstetrics, 1976, Volume: 142, Issue:2 Topics: Animals; Bone Regeneration; Burns; Cicatrix; Collagen; Disease Models, Animal; Drug Interactions; Guinea Pigs; Humans; Leukocytes; Methotrexate; Rabbits; Rats; Salicylates; Skin Transplantation; Surgery, Plastic; Tendon Injuries; Wound Healing	1976
Canine models of bone marrow transplantation. Laboratory animal science, 1990, Volume: 40, Issue:1 Topics: Animals; Antibodies, Monoclonal; Bone Marrow Transplantation; Cyclosporins; Disease Models, Animal; Dogs; Graft Enhancement, Immunologic; Graft vs Host Disease; Immunosuppression Therapy; Methotrexate; Models, Biological	1990
The effect of selected immunomodulating agents on experimental contact reactions. Acta dermato-venereologica. Supplementum, 1985, Volume: 116 Topics: Animals; Azathioprine; Basophils; Cell Division; Croton Oil; Cyclophosphamide; Cyclosporins; Dermatitis, Contact; Disease Models, Animal; Drug Administration Schedule; Female; Guinea Pigs; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppression Therapy; Mast Cells; Methotrexate; Oxazolone	1985
Immunopathological comparisons between experimental autoimmune encephalomyelitis and multiple sclerosis. Clinical and experimental immunology, 1973, Volume: 15, Issue:4 Topics: Animals; Antibody Formation; Antigens; Autoimmune Diseases; Cell Migration Inhibition; Cyclophosphamide; Disease Models, Animal; Encephalomyelitis; Guinea Pigs; Haplorhini; Humans; Immunity, Cellular; Immunization; Immunoglobulin G; Lymphocyte Activation; Methotrexate; Multiple Sclerosis; Myelin Basic Protein; Nerve Tissue Proteins; Protein Binding; Rabbits; Rats; Skin Tests; Virus Diseases	1973
Chemotherapy of bronchial carcinoma. B.T.T.A. review, 1973, Volume: 3, Issue:2 Topics: Animals; Antimetabolites; Antineoplastic Agents; Blood Cell Count; Bone Marrow Diseases; Bronchial Neoplasms; Cyclophosphamide; Disease Models, Animal; Drug Combinations; Fluorouracil; Humans; Methotrexate; Pleural Effusion; Prognosis; Vascular Diseases; Vena Cava, Superior; Vincristine	1973
The chemotherapy of human and animal acute leukemia. Cancer chemotherapy reports, 1971, Volume: 55, Issue:4 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine	1971

Trials

2 trial(s) available for methotrexate and Disease Models, Animal

Article	Year
Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response. PloS one, 2016, Volume: 11, Issue:2 Topics: Adalimumab; Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; CD18 Antigens; Chronic Disease; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Mice, Inbred C57BL; Mice, Inbred Strains; Middle Aged; Synovial Fluid; Treatment Outcome	2016
The chemotherapy of human and animal acute leukemia. Cancer chemotherapy reports, 1971, Volume: 55, Issue:4 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine	1971

Article

Year

Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

PloS one, 2016, Volume: 11, Issue:2

Topics: Adalimumab; Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; CD18 Antigens; Chronic Disease; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Male; Methotrexate; Mice, Inbred C57BL; Mice, Inbred Strains; Middle Aged; Synovial Fluid; Treatment Outcome

2016

The chemotherapy of human and animal acute leukemia.

Cancer chemotherapy reports, 1971, Volume: 55, Issue:4

Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine

1971

Other Studies

330 other study(ies) available for methotrexate and Disease Models, Animal

Article	Year
Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Disease Models, Animal; Female; Folic Acid Antagonists; Glutamic Acid; In Vitro Techniques; Inflammatory Bowel Diseases; Liver; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Quinazolines; Rats; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	2003
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger	2004
Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease. Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13 Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Female; Humans; Immunologic Factors; Indoles; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Microsomes; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Structure-Activity Relationship	2012
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastati Bioorganic & medicinal chemistry, 2013, Mar-01, Volume: 21, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Design; Humans; Melanoma, Experimental; Mice; Mice, Nude; Microwaves; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship	2013
Synthesis, antinociceptive and anti-inflammatory effects of porphyrins. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Edema; Erythrocytes; Hemolysis; Indomethacin; Male; Mice; Naproxen; Nociception; Pain; Pain Measurement; Porphyrins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate	2015
Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors. Bioorganic & medicinal chemistry letters, 2016, 09-01, Volume: 26, Issue:17 Topics: Amines; Animals; Arthritis; Binding Sites; Disease Models, Animal; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Mice; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Isoforms; Protein Kinase Inhibitors; Protein Structure, Tertiary; Structure-Activity Relationship; Triazines	2016
Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats. Journal of natural products, 2016, 10-28, Volume: 79, Issue:10 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Female; Gelsemium; Indole Alkaloids; Interleukin-1beta; Male; Methotrexate; Molecular Structure; Rats; Rats, Inbred Lew; Rats, Wistar; Tumor Necrosis Factor-alpha	2016
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. Journal of medicinal chemistry, 2019, 03-14, Volume: 62, Issue:5 Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Models, Animal; Histone Deacetylase Inhibitors; Humans; Hydrocarbons, Fluorinated; Hydroxamic Acids; Mice; Pancreatic Neoplasms; Sulfonamides	2019
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis. Bioorganic & medicinal chemistry, 2020, 01-15, Volume: 28, Issue:2 Topics: Aminopterin; Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; Injections, Intraperitoneal; Methotrexate; Molecular Structure; Prodrugs; Rats; Reactive Oxygen Species; Structure-Activity Relationship	2020
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model. International journal of molecular sciences, 2021, Sep-04, Volume: 22, Issue:17 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Inflammation; Ligation; Lung; Male; Methotrexate; Punctures; Rats; Rats, Sprague-Dawley; Sepsis	2021
Nephroprotective effect of naringin in methotrexate induced renal toxicity in male rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Caspase 3; Disease Models, Animal; Flavanones; Inflammation Mediators; Interleukin-6; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Rats; Tumor Necrosis Factor-alpha	2021
Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: Targeting oxidative stress, energy deficit and spermatogenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143 Topics: Animals; Antioxidants; Disease Models, Animal; Energy Metabolism; Fibrosis; Ginkgo biloba; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Rats, Wistar; Spermatogenesis; Spermatozoa; Testicular Diseases; Testis	2021
Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144 Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Doublecortin Protein; Hippocampus; Male; Memory; Memory Disorders; Metformin; Methotrexate; Neurogenesis; NF-E2-Related Factor 2; Nootropic Agents; Open Field Test; Oxidative Stress; Prefrontal Cortex; Rats, Sprague-Dawley	2021
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation. Cells, 2021, 12-02, Volume: 10, Issue:12 Topics: Animals; Apoptosis; Boron; Boron Neutron Capture Therapy; Brain; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Cranial Irradiation; Disease Models, Animal; Humans; Lymphoma; Methotrexate; Mice; Phenylalanine; Tissue Distribution	2021
Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats. International immunopharmacology, 2022, Volume: 103 Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Disease Models, Animal; Humans; Hydroxyethylrutoside; Inflammation; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents	2022
Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate. Neuropharmacology, 2022, 03-15, Volume: 206 Topics: Age Factors; Animals; Antimetabolites, Antineoplastic; Apoptosis; Behavior, Animal; Cancer Survivors; Cognitive Dysfunction; Disease Models, Animal; Female; Male; Methotrexate; Microglia; Neurogenesis; Neurotoxicity Syndromes; Rats; Rats, Long-Evans; Sex Factors; Time Factors	2022
Capsaicin ameliorate the nephrotoxicity induced by methotrexate. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Capsaicin; Disease Models, Animal; Inflammation Mediators; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Rats, Sprague-Dawley	2021
Oral-recombinant Methioninase Converts an Osteosarcoma from Methotrexate-resistant to -sensitive in a Patient-derived Orthotopic-xenograft (PDOX) Mouse Model. Anticancer research, 2022, Volume: 42, Issue:2 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carbon-Sulfur Lyases; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Osteosarcoma; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays	2022
Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model. Journal of ethnopharmacology, 2022, Jun-28, Volume: 292 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Bilirubin; Biological Availability; Boswellia; Diclofenac; Disease Models, Animal; Malondialdehyde; Methotrexate; Plant Extracts; Triterpenes	2022
Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis. The Journal of pharmacy and pharmacology, 2022, Sep-01, Volume: 74, Issue:9 Topics: Animals; Ceramides; Cholesterol; Disease Models, Animal; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Surface-Active Agents	2022
Prenatal methotrexate injection increases behaviors possibly associated with depression and/or autism in rat offspring; A new animal model for mental disorder, based on folate metabolism deficit during pregnancy. Neuropsychopharmacology reports, 2022, Volume: 42, Issue:3 Topics: Animals; Autistic Disorder; Behavior, Animal; Depression; Disease Models, Animal; DNA; Female; Folic Acid; Humans; Mental Disorders; Methotrexate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Vitamins	2022
Chemo-photothermal therapeutic effect of chitosan-gelatin hydrogels containing methotrexate and melanin on a collagen-induced arthritis mouse model. International journal of biological macromolecules, 2022, Oct-01, Volume: 218 Topics: Animals; Arthritis, Experimental; Chitosan; Disease Models, Animal; Doxorubicin; Gelatin; Hydrogels; Infrared Rays; Melanins; Methotrexate; Mice; Phototherapy	2022
Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model. Drug delivery and translational research, 2023, Volume: 13, Issue:7 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Inflammation; Methotrexate; Mice; Vaccines	2023
Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model. BMC cancer, 2023, Nov-13, Volume: 23, Issue:1 Topics: Animals; Choriocarcinoma, Non-gestational; Chorionic Gonadotropin; Cisplatin; Disease Models, Animal; Female; Heterografts; Humans; Methotrexate; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Tumor Microenvironment; Xenograft Model Antitumor Assays	2023
Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model. International journal of pharmaceutics, 2019, Oct-05, Volume: 569 Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Female; Folic Acid Antagonists; Imiquimod; Immunosuppressive Agents; Liposomes; Methotrexate; Mice, Inbred BALB C; Psoriasis	2019
Development of Topical Gel of Methotrexate Incorporated Ethosomes and Salicylic Acid for the Treatment of Psoriasis. Pharmaceutical nanotechnology, 2019, Volume: 7, Issue:5 Topics: Acrylates; Administration, Cutaneous; Animals; Antipsychotic Agents; Disease Models, Animal; Drug Compounding; Drug Liberation; Gels; Guinea Pigs; Humans; Lecithins; Liposomes; Methotrexate; Mice; Parakeratosis; Permeability; Psoriasis; Salicylic Acid; Skin; Skin Absorption	2019
Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment. The Korean journal of internal medicine, 2019, Volume: 34, Issue:6 Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Interleukin-1beta; Lung; Lung Diseases; Lutein; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats, Wistar; Tumor Necrosis Factor-alpha	2019
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. Life sciences, 2020, Feb-01, Volume: 242 Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior	2020
Hyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis. ACS applied materials & interfaces, 2019, Nov-20, Volume: 11, Issue:46 Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Female; Humans; Hyaluronic Acid; Methotrexate; Mice; Mice, Inbred BALB C; Needles; Psoriasis	2019
Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model. Toxicological sciences : an official journal of the Society of Toxicology, 2020, 01-01, Volume: 173, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; CA1 Region, Hippocampal; Chemotherapy, Adjuvant; Cyclophosphamide; Dendrites; Dendritic Spines; Disease Models, Animal; Female; Fluorouracil; Hippocampus; Methotrexate; Mice; Neurons; Quality of Life	2020
Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis. The Journal of investigative dermatology, 2020, Volume: 140, Issue:5 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Gold; Humans; Imiquimod; Immunity; Methotrexate; Mice; Mice, Inbred C57BL; Nanoparticles; Psoriasis; Skin; Th17 Cells; Xenograft Model Antitumor Assays	2020
Preparation and Characterization of Fe International journal of nanomedicine, 2019, Volume: 14 Topics: 3T3 Cells; Animals; Apoptosis; Cell Line, Tumor; Central Nervous System Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Female; Ferric Compounds; Humans; Hyperthermia, Induced; Lymphoma; Magnetite Nanoparticles; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Temperature; Toxicity Tests, Acute	2019
Modulation of methotrexate-induced intestinal mucosal injury by dietary factors. Human & experimental toxicology, 2020, Volume: 39, Issue:4 Topics: Animals; Diet, High-Fat; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Intestinal Diseases; Intestinal Mucosa; Male; Metabolome; Methotrexate; Mice, Inbred C57BL; Sucrose; Survival Analysis; Tissue Distribution	2020
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis. Chemico-biological interactions, 2020, Mar-01, Volume: 319 Topics: Animals; Antioxidants; Arthritis, Experimental; Arthritis, Rheumatoid; Catalase; Disease Models, Animal; Diterpenes; Edema; Freund's Adjuvant; Glutathione; Inflammation; Interleukin-1beta; Interleukin-6; Joints; Male; Methotrexate; Neutrophils; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Synovial Membrane; Tumor Necrosis Factor-alpha	2020
Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats. Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hesperidin; Inflammation Mediators; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Protein p53	2020
Long-term clinically relevant rodent model of methotrexate-induced cognitive impairment. Neuro-oncology, 2020, 08-17, Volume: 22, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Cognitive Dysfunction; Diffusion Tensor Imaging; Disease Models, Animal; Female; Male; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; White Matter	2020
Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects. Toxicology, 2020, 05-15, Volume: 437 Topics: Animals; Bosentan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flavonoids; Food-Drug Interactions; HEK293 Cells; Herb-Drug Interactions; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Molecular Conformation; Organic Anion Transporters; Rats, Sprague-Dawley; Structure-Activity Relationship	2020
Application of either nano fibrillated cellulose methotrexate or nano silicon dioxide methotrexate composites against renal fibrosis in leukemia rat model. International journal of biological macromolecules, 2020, Aug-15, Volume: 157 Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Cellulose; Disease Models, Animal; Drug Carriers; Fibrosis; Kidney Diseases; Leukemia; Male; Methotrexate; Nanofibers; Nanoparticles; Rats; Silicon Dioxide	2020
Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. Bioscience reports, 2020, 06-26, Volume: 40, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Carcinoma, Hepatocellular; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Hep G2 Cells; Humans; Inflammation Mediators; Liver; Liver Neoplasms; Male; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats	2020
The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 128 Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Inflammation Mediators; Kidney; Kidney Diseases; Liver; Male; Methotrexate; Mice; Moringa oleifera; Oxidative Stress; Plant Extracts; Plant Leaves; Signal Transduction	2020
Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nature biomedical engineering, 2020, Volume: 4, Issue:7 Topics: Animals; Antitussive Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Bone Marrow; Cell Death; Cholangiocarcinoma; Cholestasis; Disease Models, Animal; Female; HEK293 Cells; Humans; Methotrexate; Mice; Mice, Inbred C57BL; Neutrophils; Perfusion	2020
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131 Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Doublecortin Protein; Hippocampus; Hypoglycemic Agents; Male; Memory Disorders; Metformin; Methotrexate; Neurogenesis; Random Allocation; Rats; Rats, Sprague-Dawley	2020
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways. Immunopharmacology and immunotoxicology, 2020, Volume: 42, Issue:5 Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Janus Kinase 1; Liver; Male; Methotrexate; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Quinolones; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Transcription Factor RelA	2020
Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8 Theranostics, 2020, Volume: 10, Issue:23 Topics: Animals; Artemisinins; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Imiquimod; Immunologic Memory; Interleukin-15; Interleukin-17; Male; Methotrexate; Mice; Psoriasis; Recurrence; Secondary Prevention; Skin; Skin Transplantation; Transplantation Chimera	2020
Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats. Biomedical research (Tokyo, Japan), 2020, Volume: 41, Issue:5 Topics: Animals; Benzamidines; Cisplatin; Disease Models, Animal; Guanidines; Ileum; Intestine, Small; Male; Methotrexate; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Serotonin	2020
MTX Treatment Does Not Improve Outcome in Mice with AMI. Pharmacology, 2021, Volume: 106, Issue:3-4 Topics: Animals; Blood Cell Count; Blood Platelets; Disease Models, Animal; Male; Methotrexate; Mice, Inbred C57BL; Myocardial Infarction; Serum Amyloid P-Component; Systole; Treatment Outcome; Ventricular Function, Left	2021
Refinement and validation of infrared thermal imaging (IRT): a non-invasive technique to measure disease activity in a mouse model of rheumatoid arthritis. Arthritis research & therapy, 2020, 11-30, Volume: 22, Issue:1 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Methotrexate; Mice; Reproducibility of Results	2020
Methotrexate Therapy Promotes Cell Coverage and Stability in in-Stent Neointima. Cardiovascular drugs and therapy, 2021, Volume: 35, Issue:5 Topics: Anaplastic Lymphoma Kinase; Animals; Apoptosis; Carotid Artery, Common; Cell Proliferation; Disease Models, Animal; Drug-Eluting Stents; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Male; Methotrexate; Neointima; Phosphatidylinositol 3-Kinases; Rabbits; Random Allocation	2021
Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell‑based vaccines in murine colon carcinoma. Oncology reports, 2021, Volume: 45, Issue:3 Topics: Animals; Cancer Vaccines; Carcinoma; Cell Line, Tumor; Colon; Colonic Neoplasms; Combined Modality Therapy; Dendritic Cells; Disease Models, Animal; Drug Carriers; Female; Humans; Hydroxyethyl Starch Derivatives; Intestinal Mucosa; Methotrexate; Mice; Nanoconjugates; Tumor Escape	2021
Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis. International immunopharmacology, 2021, Volume: 92 Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Experimental; Disease Models, Animal; Drug Therapy, Combination; Fish Oils; Gene Expression Regulation; Hypoglycemic Agents; Interleukin-1beta; Male; Metformin; Methotrexate; MicroRNAs; Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha	2021
In Vitro and In Vivo Efficacy of a Novel Glucose-Methotrexate Conjugate in Targeted Cancer Treatment. International journal of molecular sciences, 2021, Feb-09, Volume: 22, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Female; Folic Acid; Glucose; Glucose Transporter Type 1; Humans; Injections, Intravenous; Methotrexate; Mice	2021
Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats. Human & experimental toxicology, 2021, Volume: 40, Issue:9 Topics: Animals; Antioxidants; Disease Models, Animal; Female; Humans; Male; Methotrexate; Ovarian Diseases; Oxidative Stress; Protective Agents; Rats; Ubiquinone; Uterine Diseases	2021
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles ameliorate collagen-induced arthritis via immunomodulatory T lymphocytes. Molecular immunology, 2021, Volume: 135 Topics: Animals; Arthritis, Experimental; Cells, Cultured; Collagen; Disease Models, Animal; Extracellular Vesicles; Female; Forkhead Transcription Factors; Human Umbilical Vein Endothelial Cells; Humans; Immunomodulation; Immunosuppressive Agents; Interleukin-10; Interleukin-17; Mesenchymal Stem Cells; Methotrexate; Nuclear Receptor Subfamily 1, Group F, Member 3; Rats; Rats, Wistar; Synovial Membrane; T-Lymphocytes, Regulatory; Th17 Cells; Transforming Growth Factor beta	2021
CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion. Journal of pharmacological sciences, 2021, Volume: 146, Issue:1 Topics: Acute Kidney Injury; Animals; Apoptosis; Disease Models, Animal; Gene Expression; Glucosides; Kidney; Male; Methotrexate; Molecular Targeted Therapy; Monoterpenes; Organic Anion Transporters, Sodium-Independent; Rats, Sprague-Dawley	2021
Therapeutic effects of vitamin D and IL-22 on methotrexate-induced mucositis in mice. Anti-cancer drugs, 2022, 01-01, Volume: 33, Issue:1 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Gene Transfer Techniques; Inflammation Mediators; Interleukin-22; Interleukins; Intestinal Mucosa; Methotrexate; Mice; Mice, Inbred BALB C; Mucositis; Vitamin D; Weight Loss	2022
Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2018, Volume: 31, Issue:2 Topics: Animals; Antioxidants; Disease Models, Animal; Glutathione; Humans; Interleukin-1beta; Lung; Lung Injury; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Thioctic Acid; Tumor Necrosis Factor-alpha	2018
Therapeutic effect of quercetin in collagen-induced arthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Chemokine CCL2; Collagen; Disease Models, Animal; Inflammation; Interleukin-17; Interleukin-1beta; Joints; Methotrexate; Mice; Mice, Inbred C57BL; Protective Agents; Quercetin; Tumor Necrosis Factor-alpha	2017
Influence of Drugs Carried in Lipid Nanoparticles in Coronary Disease of Rabbit Transplanted Heart. The Annals of thoracic surgery, 2017, Volume: 104, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Coronary Artery Disease; Cytokines; Disease Models, Animal; Drug Carriers; Gene Expression Regulation; Graft Rejection; Graft Survival; Heart Transplantation; Immunohistochemistry; Immunosuppressive Agents; Injections, Intravenous; Methotrexate; Myocardium; Nanoparticles; Paclitaxel; Rabbits; Real-Time Polymerase Chain Reaction; RNA	2017
Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Scientific reports, 2017, 03-28, Volume: 7 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Movement; Chemokine CX3CL1; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; Immunosuppressive Agents; Interleukin-1beta; Lymphocyte Activation; Male; Methotrexate; Paroxetine; Rats; Rats, Wistar; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tumor Necrosis Factor-alpha	2017
mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph Molecular cancer therapeutics, 2017, Volume: 16, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; DNA Damage; Drug Resistance, Neoplasm; Female; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mercaptopurine; Methotrexate; Mice; Mice, Knockout; Models, Biological; Philadelphia Chromosome; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Xenograft Model Antitumor Assays	2017
Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. The Indian journal of medical research, 2017, Volume: 145, Issue:1 Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Doxorubicin; Drug Delivery Systems; Head and Neck Neoplasms; Humans; Methotrexate; Nanoparticles; Rats; Squamous Cell Carcinoma of Head and Neck	2017
Effects of polysaccharide fractions isolated from The Indian journal of medical research, 2017, Volume: 145, Issue:2 Topics: Animals; Arthritis; Collagen; Disease Models, Animal; Humans; Immunity, Humoral; Macrophages; Methotrexate; Mice; Phagocytes; Polysaccharides; Ranunculaceae; Sheep	2017
Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis. The journal of gene medicine, 2017, Volume: 19, Issue:8 Topics: Adalimumab; Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Female; Genetic Engineering; Genetic Therapy; Humans; Male; Methotrexate; Mice; Mice, SCID; Treatment Outcome; Tumor Necrosis Factor-alpha	2017
Combination Therapy of PEG-HM-3 and Methotrexate Retards Adjuvant-Induced Arthritis. International journal of molecular sciences, 2017, Jul-21, Volume: 18, Issue:7 Topics: Animals; Arthritis, Experimental; Body Weight; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation; Lipopolysaccharides; Macrophages; Male; Methotrexate; Peptides; Rats; Spleen; Toll-Like Receptor 4; Treatment Outcome; Tumor Necrosis Factor-alpha	2017
Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis. International journal of nanomedicine, 2017, Volume: 12 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Male; Methotrexate; Molecular Targeted Therapy; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Rats, Sprague-Dawley	2017
Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla. Pharmaceutical research, 2017, Volume: 34, Issue:12 Topics: Alzheimer Disease; Animals; Biological Transport; Brain; Disease Models, Animal; Drug Delivery Systems; Drug Discovery; Enzyme Inhibitors; Humans; Male; Membrane Transport Proteins; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pharmaceutical Preparations; Tight Junction Proteins; Transcriptome	2017
Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model. International journal of biological macromolecules, 2018, Apr-15, Volume: 110 Topics: Aminoquinolines; Animals; Chitin; Disease Models, Animal; Drug Delivery Systems; Humans; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; THP-1 Cells	2018
Protective effects of gallic acid against methotrexate-induced toxicity in rats. Acta chirurgica Belgica, 2018, Volume: 118, Issue:3 Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Biomarkers; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gallic Acid; Immunohistochemistry; Liver Function Tests; Male; Methotrexate; Multivariate Analysis; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reference Values; Risk Assessment; Superoxide Dismutase	2018
Neurobiological Mechanisms of Chemotherapy-induced Cognitive Impairment in a Transgenic Model of Breast Cancer. Neuroscience, 2018, 01-15, Volume: 369 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Female; Fluorouracil; Learning; Memory; Methotrexate; Mice; Mice, Transgenic; Neurogenesis; Organ Size; Receptors, Virus	2018
Vanillin mitigates the adverse impact of cisplatin and methotrexate on rat kidneys. Human & experimental toxicology, 2018, Volume: 37, Issue:9 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Benzaldehydes; Biomarkers; Cisplatin; Cytoprotection; Disease Models, Animal; Inflammation Mediators; Kidney; Male; Methotrexate; Nitrosative Stress; Oxidative Stress; Rats, Sprague-Dawley	2018
PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats. PloS one, 2018, Volume: 13, Issue:1 Topics: Animals; Antineoplastic Agents; Cognitive Dysfunction; Dentate Gyrus; Discrimination Learning; Disease Models, Animal; Doublecortin Protein; Enzyme Inhibitors; Female; Fluorouracil; Hippocampus; Humans; Learning; Methotrexate; Neurogenesis; Neuroprotective Agents; Pyridines; Rats; Rats, Long-Evans; Ribonucleotide Reductases; Spatial Memory; Thiosemicarbazones	2018
Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy. EBioMedicine, 2018, Volume: 29 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Fertility; Gefitinib; Heterografts; Humans; Methotrexate; Mice; Microtubules; Miosis; Placenta; Pregnancy; Pregnancy, Ectopic; Quinazolines; Trophoblasts; Vinblastine; Vinorelbine	2018
Pharmacological characterisation of CR6086, a potent prostaglandin E Arthritis research & therapy, 2018, 03-01, Volume: 20, Issue:1 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclic AMP; Cytokines; Disease Models, Animal; Drug Therapy, Combination; HEK293 Cells; Humans; Macrophages; Male; Methotrexate; Mice, Inbred DBA; Radioligand Assay; Rats, Inbred Lew; Receptors, Prostaglandin E, EP4 Subtype; THP-1 Cells; Vascular Endothelial Growth Factor A	2018
Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats. Acta chirurgica Belgica, 2019, Volume: 119, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ellagic Acid; Glutathione; Immunosuppressive Agents; Liver; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar	2019
Abrogation of Hepatic Damage Induced by Anticancer Drug Methotrexate by Zobo (Hibiscus sabdariffa extract) Supplementation via Targeting Oxidative Hepatotoxicity in Rats. Journal of dietary supplements, 2019, Volume: 16, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Dietary Supplements; Disease Models, Animal; Hibiscus; Lipid Peroxidation; Liver; Male; Methotrexate; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar	2019
Notch-1 siRNA and Methotrexate towards a Multifunctional Approach in Rhematoid Arthritis Management: a Nanomedicine Approach. Pharmaceutical research, 2018, Apr-20, Volume: 35, Issue:6 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Disease Models, Animal; Drug Carriers; Drug Compounding; Ethylene Oxide; Genetic Therapy; Human Umbilical Vein Endothelial Cells; Humans; Lactones; Methotrexate; Mice; Micelles; Nanomedicine; Polyesters; Polyethylene Glycols; Polyethyleneimine; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Receptor, Notch1; RNA, Small Interfering; Signal Transduction; Synoviocytes; Treatment Outcome	2018
Regression of Atherosclerotic Plaques of Cholesterol-Fed Rabbits by Combined Chemotherapy With Paclitaxel and Methotrexate Carried in Lipid Core Nanoparticles. Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:6 Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Cardiovascular Agents; Cholesterol, Dietary; Cytokines; Disease Models, Animal; Drug Compounding; Drug Therapy, Combination; Inflammation Mediators; Lipids; Liposomes; Male; Matrix Metalloproteinase 9; Methotrexate; Nanoparticles; Paclitaxel; Plaque, Atherosclerotic; Rabbits	2018
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Frontiers in immunology, 2018, Volume: 9 Topics: Adenosine; Animals; Arthritis, Rheumatoid; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunosuppressive Agents; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Male; Methotrexate; Mice; Monocytes; Purines; Synovial Fluid	2018
Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate. Translational research : the journal of laboratory and clinical medicine, 2018, Volume: 199 Topics: Alkaline Phosphatase; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Drug Therapy, Combination; Liver; Macrophages; Male; Methotrexate; Positron Emission Tomography Computed Tomography; Rats, Wistar; Recombinant Proteins; Spleen; Synovial Membrane; Tissue Distribution	2018
Methotrexate and BAFF interaction prevents immunization against TNF inhibitors. Annals of the rheumatic diseases, 2018, Volume: 77, Issue:10 Topics: 5'-Nucleotidase; Adenosine; Animals; Antibody Formation; Antigens, CD; Apyrase; Autoimmune Diseases; B-Cell Activating Factor; B-Lymphocytes; Disease Models, Animal; Drug Resistance; Humans; Immunization; Macaca; Methotrexate; Mice; Mice, Transgenic; Tumor Necrosis Factor-alpha	2018
Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106 Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Commiphora; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Inflammation Mediators; Kidney; Lipid Peroxidation; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plants, Medicinal; Rats, Wistar; Resins, Plant; Signal Transduction	2018
Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota. EBioMedicine, 2018, Volume: 33 Topics: Animals; Bacteria; Bacteroides fragilis; Caco-2 Cells; Dendritic Cells; Disease Models, Animal; Gastrointestinal Diseases; Gastrointestinal Microbiome; Humans; Macrophages; Male; Methotrexate; Mice; Phylogeny; RAW 264.7 Cells; Time Factors	2018
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. Cell, 2019, 01-10, Volume: 176, Issue:1-2 Topics: Animals; Brain; Cell Differentiation; Cell Lineage; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Mice; Microglia; Myelin Sheath; Nerve Fibers, Myelinated; Neurogenesis; Neuroglia; Neurons; Oligodendroglia; White Matter	2019
Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study. Drug design, development and therapy, 2019, Volume: 13 Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Lipid Peroxidation; Liver; Male; Methotrexate; Molsidomine; Oxidative Stress; Rats, Wistar	2019
Autologous tumor cell-derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion. Science translational medicine, 2019, 01-09, Volume: 11, Issue:474 Topics: Animals; Cell Death; Cell Line, Tumor; Cell-Derived Microparticles; Disease Models, Animal; Endocytosis; Humans; Lung Neoplasms; Methotrexate; Mice, Inbred C57BL; Neoplasm Staging; Pleural Effusion, Malignant; Tissue Distribution; Transplantation, Autologous; Tumor Microenvironment	2019
Combination leflunomide and methotrexate impedes the recovery of liver fibrosis, partly through inhibition of myeloid cell admittance. Molecular medicine reports, 2019, Volume: 19, Issue:3 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Collagen Type III; Collagen Type IV; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Female; Hepatic Stellate Cells; Humans; Hyaluronic Acid; Laminin; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Mice; Monocytes; Myeloid Cells; Vascular Endothelial Growth Factor A	2019
Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway. Life sciences, 2019, Feb-15, Volume: 219 Topics: Animals; Blotting, Western; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hesperidin; Humans; Imiquimod; Keratinocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Real-Time Polymerase Chain Reaction	2019
Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model. Nanomedicine : nanotechnology, biology, and medicine, 2019, Volume: 17 Topics: Administration, Topical; Animals; Disease Models, Animal; Drug Carriers; Gold; Immunosuppressive Agents; Metal Nanoparticles; Methotrexate; Mice; Mice, Inbred C57BL; Psoriasis; Sulfhydryl Compounds	2019
Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats. Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:1 Topics: Animals; Dermatologic Agents; Disease Models, Animal; Female; Male; Methotrexate; Plant Extracts; Potassium Iodide; Psoriasis; Rats; Severity of Illness Index; Skin; Solvents; Spinacia oleracea; Water	2019
cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis. The Journal of investigative dermatology, 2019, Volume: 139, Issue:9 Topics: Adjuvants, Immunologic; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cells, Cultured; Coumarins; Disease Models, Animal; Female; Gene Knockdown Techniques; Hepatocytes; Humans; Imiquimod; Macrophages; Male; Methotrexate; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Toxicity Tests	2019
Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis. Life sciences, 2019, Jun-01, Volume: 226 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Disease Models, Animal; Freund's Adjuvant; Interleukin-17; Interleukin-6; Male; Matrix Metalloproteinase 3; Methotrexate; NF-kappa B; Oxidative Stress; RANK Ligand; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Venlafaxine Hydrochloride	2019
Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European journal of pharmacology, 2019, Jun-15, Volume: 853 Topics: Animals; Arthritis, Experimental; Collagen; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Male; Methotrexate; Mice; Polyglutamic Acid	2019
Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in mice. Cancer chemotherapy and pharmacology, 2019, Volume: 84, Issue:1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antioxidants; beta-Glucans; Disease Models, Animal; Free Radical Scavengers; Immunity, Innate; Intestinal Mucosa; Male; Metabolomics; Methotrexate; Mice; Mice, Inbred C57BL; Mucositis; Oxidative Stress	2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment. Neuron, 2019, 07-17, Volume: 103, Issue:2 Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Channelrhodopsins; Cognition Disorders; Disease Models, Animal; Humans; Immunosuppressive Agents; Luminescent Proteins; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath; Oligodendrocyte Precursor Cells; Organic Chemicals; Protein-Tyrosine Kinases; Recognition, Psychology; Signal Transduction; Urea	2019
Protocatechuic acid inhibits testicular and epididymal toxicity associated with methotrexate in rats. Andrologia, 2019, Volume: 51, Issue:9 Topics: Animals; Dietary Supplements; Disease Models, Animal; Epididymis; Humans; Hydroxybenzoates; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Spermatogenesis; Testicular Diseases; Testis	2019
Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity. JCI insight, 2019, 07-25, Volume: 4, Issue:14 Topics: Animals; Carbon; Disease Models, Animal; Glycine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoquinolines; Liver; Metabolic Networks and Pathways; Methotrexate; Mice; Mice, Knockout; Oxygen; Protein Stability; Retina; Retinopathy of Prematurity; Serine; Tissue Culture Techniques; Up-Regulation	2019
Intravitreal injection of methotrexate in an experimental rabbit model: determination of ultrastructural changes. Indian journal of ophthalmology, 2013, Volume: 61, Issue:7 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Female; Follow-Up Studies; Immunosuppressive Agents; Intravitreal Injections; Male; Methotrexate; Microscopy, Electron; Rabbits; Retina; Retinal Diseases	2013
Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma. Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Activation; Female; Gene Silencing; Humans; Melanoma; Methotrexate; Methylation; Mice; Myosin Heavy Chains; Myosin Type V; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Xenograft Model Antitumor Assays	2013
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. Journal of virology, 2013, Volume: 87, Issue:17 Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus	2013
Role of methotrexate exposure in apoptosis and proliferation during early neurulation. Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8 Topics: Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Down-Regulation; Embryonic Development; Epithelial Cells; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Histones; Methotrexate; Mice; Mice, Inbred C57BL; Microarray Analysis; Neural Tube Defects; Neurulation; Pregnancy; Tetrahydrofolate Dehydrogenase; Up-Regulation	2014
Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Molecular therapy : the journal of the American Society of Gene Therapy, 2014, Volume: 22, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Citrus paradisi; Colitis; Dextran Sulfate; Disease Models, Animal; Drug Delivery Systems; Gene Expression Regulation; Heme Oxygenase-1; Humans; Inflammatory Bowel Diseases; Interleukin-1beta; Intestinal Mucosa; Macrophages; Male; Methotrexate; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Nanostructures; Plant Extracts; Tumor Necrosis Factor-alpha	2014
Methotrexate treatment causes early onset of disease in a mouse model of Ross River virus-induced inflammatory disease through increased monocyte production. PloS one, 2013, Volume: 8, Issue:8 Topics: Alphavirus Infections; Animals; Antirheumatic Agents; Arthritis; CD11b Antigen; Disease Models, Animal; Inflammation; Inflammation Mediators; Methotrexate; Mice; Monocytes; Muscle, Skeletal; Ross River virus	2013
Carrier-free functionalized multidrug nanorods for synergistic cancer therapy. Biomaterials, 2013, Volume: 34, Issue:35 Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Carriers; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; KB Cells; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Nanotubes; Neoplasms; Paclitaxel	2013
Evaluation of therapeutic efficacy of Majoon Suranjan, a Unani formulation, in the treatment of rheumatoid arthritis: an experimental study. Experimental biology and medicine (Maywood, N.J.), 2013, Volume: 238, Issue:12 Topics: Animals; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cattle; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Medicine, Unani; Methotrexate; Phytotherapy; Rats; Rats, Wistar; Rheumatoid Factor	2013
Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artificial cells, nanomedicine, and biotechnology, 2014, Volume: 42, Issue:6 Topics: Administration, Topical; Animals; Combined Modality Therapy; Disease Models, Animal; Humans; Liposomes; Methotrexate; Mice, Inbred Strains; Nanospheres; Orthokeratologic Procedures; Parakeratosis; Photochemotherapy; Psoriasis; Trioxsalen; Ultraviolet Therapy	2014
Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model. Nutrients, 2013, Sep-30, Volume: 5, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Beverages; Body Weight; Cell Proliferation; Diarrhea; Diet; Disease Models, Animal; Female; Goblet Cells; Methotrexate; Mucositis; Neoplasms; Nutritional Status; Random Allocation; Rats	2013
Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats. Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:4 Topics: Animals; Arginine; Dietary Supplements; Disease Models, Animal; Gastrointestinal Tract; Glutamine; Immunohistochemistry; Intestines; Male; Methotrexate; Mucositis; NF-kappa B; Occludin; Rats; Rats, Sprague-Dawley; RNA, Messenger	2014
Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats. Pharmaceutical biology, 2014, Volume: 52, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Methotrexate; Plant Extracts; Plant Roots; Powders; Rats; Rats, Wistar; Severity of Illness Index; Withania	2014
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis. Human & experimental toxicology, 2014, Volume: 33, Issue:10 Topics: Animals; Cell Survival; Disease Models, Animal; Electron Transport; Electron Transport Chain Complex Proteins; Enteritis; Enterocytes; Intestine, Small; Male; Methotrexate; Mitochondria; Mitochondrial Diseases; Peroxynitrous Acid; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Time Factors; Weight Loss	2014
The efficacy of minocycline against methotrexate-induced pulmonary fibrosis in mice. European review for medical and pharmacological sciences, 2013, Volume: 17, Issue:24 Topics: Animals; Antioxidants; Catalase; Cytoprotection; Disease Models, Animal; Lung; Malondialdehyde; Methotrexate; Mice; Minocycline; Oxidative Stress; Pulmonary Fibrosis; Time Factors	2013
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects. Developmental neurobiology, 2014, Volume: 74, Issue:9 Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates	2014
The effect of methotrexate on the bone healing of mandibular condylar process fracture: an experimental study in rats. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2014, Volume: 42, Issue:7 Topics: Alkaline Phosphatase; Animals; Atrophy; Bone Remodeling; Bone Resorption; Bony Callus; Cartilage, Articular; Connective Tissue; Disease Models, Animal; Fibrocartilage; Fracture Healing; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Mandibular Condyle; Mandibular Fractures; Methotrexate; Osteogenesis; Random Allocation; Rats; Rats, Wistar; Temporomandibular Joint; Tissue Survival	2014
Prediction of antiarthritic drug efficacies by monitoring active matrix metalloproteinase-3 (MMP-3) levels in collagen-induced arthritic mice using the MMP-3 probe. Molecular pharmaceutics, 2014, May-05, Volume: 11, Issue:5 Topics: Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Infliximab; Matrix Metalloproteinase 3; Methotrexate; Mice; Molecular Probes	2014
1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis. Autoimmunity, 2014, Volume: 47, Issue:6 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Cytokines; Disease Models, Animal; Drug Synergism; Inflammation; Methotrexate; Mice; Tryptophan; Tryptophan Oxygenase	2014
Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 142, Issue:1 Topics: Animals; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Feces; Kidney; Liver; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Tissue Distribution	2014
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World journal of gastroenterology, 2014, Aug-07, Volume: 20, Issue:29 Topics: Acetylcysteine; Amifostine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Male; Methotrexate; Oxidative Stress; Rats, Sprague-Dawley; Time Factors	2014
Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 142, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Folic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methotrexate; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Sprague-Dawley; Tissue Distribution	2014
Effect of methotrexate upon antigen-induced arthritis of the rabbit temporomandibular joint. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2015, Volume: 44, Issue:8 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Female; Inflammation; Injections, Intra-Articular; Methotrexate; Ovalbumin; Rabbits; Random Allocation; Temporomandibular Joint; Temporomandibular Joint Disorders	2015
The effect of colchicine and low-dose methotrexate on intestinal ischemia/reperfusion injury in an experimental model. Journal of pediatric surgery, 2014, Volume: 49, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Colchicine; Disease Models, Animal; Ileal Diseases; Intestines; Male; Methotrexate; Rats; Rats, Wistar; Reperfusion Injury	2014
Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis. Molecular medicine reports, 2015, Volume: 11, Issue:1 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Disease Models, Animal; Female; Immunosuppressive Agents; Male; Methotrexate; Mice; Sesquiterpenes, Guaiane	2015
The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. PloS one, 2014, Volume: 9, Issue:11 Topics: Animals; Apoptosis; beta Catenin; Caco-2 Cells; Cell Proliferation; Disease Models, Animal; Enterocytes; Humans; Intestinal Mucosa; Intestines; Male; Methotrexate; Mucositis; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway	2014
Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015, Volume: 64, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; B-Lymphocytes; Cells, Cultured; Collagen; Cytokines; Disease Models, Animal; Humans; In Vitro Techniques; Inflammation; Interferon-gamma; Interleukin-2; Janus Kinases; Mast Cells; Methotrexate; Mice; Mice, Inbred DBA; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; Signal Transduction; T-Lymphocytes	2015
New formulated "DOX-MTX-loaded nanoparticles" down- regulate HER2 gene expression and improve the clinical outcome in OSCCs model in rat: the effect of IV and oral modalities. Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:21 Topics: Administration, Oral; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chi-Square Distribution; Disease Models, Animal; Down-Regulation; Doxorubicin; Drug Delivery Systems; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Infusions, Intravenous; Male; Methotrexate; Molecular Targeted Therapy; Mouth Neoplasms; Nanoparticles; Neoplasms, Experimental; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Treatment Outcome	2014
Whole-scale neurobehavioral assessments of photothrombotic ischemia in freely moving mice. Journal of neuroscience methods, 2015, Jan-15, Volume: 239 Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Infarction; Brain Ischemia; Disease Models, Animal; Etoposide; Exercise Test; Ifosfamide; Intracranial Thrombosis; Lasers; Locomotion; Male; Methotrexate; Mice; Mice, Inbred Strains; Movement Disorders; Rotarod Performance Test; Wakefulness	2015
Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis. TheScientificWorldJournal, 2014, Volume: 2014 Topics: Animals; Body Weight; Busulfan; Chromatography, High Pressure Liquid; Disease Models, Animal; Feeding Behavior; Female; Methotrexate; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats, Wistar; Solanum nigrum; Stomatitis; Survival Analysis; Toxicity Tests, Acute; Water	2014
Olmesartan decreased levels of IL-1β and TNF-α, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model. PloS one, 2014, Volume: 9, Issue:12 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Bacteremia; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Down-Regulation; Imidazoles; Immunohistochemistry; Interleukin-1beta; Intestine, Small; Leukocytosis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; Mucositis; RANK Ligand; Rats; Rats, Wistar; Receptor Activator of Nuclear Factor-kappa B; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Tetrazoles; Tumor Necrosis Factor-alpha; Up-Regulation	2014
Sugarcane bagasse lignin, and silica gel and magneto-silica as drug vehicles for development of innocuous methotrexate drug against rheumatoid arthritis disease in albino rats. Materials science & engineering. C, Materials for biological applications, 2015, Volume: 48 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulose; Disease Models, Animal; Drug Carriers; Knee Joint; Magnetic Fields; Male; Methotrexate; Rats; Saccharum; Silica Gel	2015
Methotrexate induced apoptotic and necrotic chromatin changes in rat myeloid leukemia cells. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015, Volume: 64, Issue:3-4 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Marrow Cells; Cell Cycle; Cells, Cultured; Chromatin; Disease Models, Animal; DNA Packaging; Dose-Response Relationship, Drug; Leukemia, Myeloid; Male; Methotrexate; Rats; Rats, Long-Evans	2015
Effects of silymarin on methotrexate-induced nephrotoxicity in rats. Renal failure, 2015, Volume: 37, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Disease Models, Animal; Kidney Diseases; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Silymarin	2015
Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate. Toxicon : official journal of the International Society on Toxinology, 2015, Volume: 98 Topics: Aminopeptidases; Animals; Antirheumatic Agents; Arthritis, Experimental; Bee Venoms; CD13 Antigens; Cyanosis; Dipeptidyl Peptidase 4; Disease Models, Animal; Edema; Hyperalgesia; Inflammation; Leukocytes, Mononuclear; Male; Methotrexate; Pain; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha	2015
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis. PloS one, 2015, Volume: 10, Issue:3 Topics: Animals; Antibodies; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Combined Modality Therapy; Cytokines; Disease Models, Animal; Heat-Shock Proteins; Hyperthermia, Induced; Joints; Macrophage Activation; Macrophages; Methotrexate; Mice; NF-kappa B; STAT1 Transcription Factor; T-Lymphocytes	2015
Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism. PloS one, 2015, Volume: 10, Issue:3 Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; DNA Methylation; Embryonic Development; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Protein Serine-Threonine Kinases; Tandem Mass Spectrometry; Ubiquitin-Protein Ligases; Wnt Signaling Pathway	2015
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats. Environmental toxicology and pharmacology, 2015, Volume: 39, Issue:3 Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Kidney Diseases; Male; Methotrexate; Pentoxifylline; Rats; Rats, Sprague-Dawley; Thioctic Acid	2015
In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:5 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Diarrhea; Disease Models, Animal; Imidazoles; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mucositis; Neoplasms; Olmesartan Medoxomil; Rats, Wistar; Sucrose; Tetrazoles; Tumor Necrosis Factor-alpha; Weight Loss	2015
Therapeutic effect of methotrexate encapsulated in cationic liposomes (EndoMTX) in comparison to free methotrexate in an antigen-induced arthritis study in vivo. Scandinavian journal of rheumatology, 2015, Volume: 44, Issue:6 Topics: Administration, Intravenous; Animals; Antigens, Bacterial; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Blood Platelets; Capsules; Cell Communication; Disease Models, Animal; Endothelial Cells; Female; Knee Joint; Leukocytes; Liposomes; Methotrexate; Mice; Mice, Inbred C57BL; Microcirculation; Radiography; Treatment Outcome	2015
DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. Journal of immunology research, 2015, Volume: 2015 Topics: Animals; Antigens, Surface; Arthritis, Experimental; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Female; Immune Tolerance; Immunophenotyping; Immunosuppression Therapy; Immunosuppressive Agents; Immunotherapy, Adoptive; Lymphoid Tissue; Methotrexate; Mice; Phenotype; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells	2015
Prevention of methotrexate-induced nephrotoxicity by concomitant administration of garlic aqueous extract in rat. Turkish journal of medical sciences, 2015, Volume: 45, Issue:3 Topics: Adenosine Deaminase; Animals; Calcium; Catalase; Creatinine; Disease Models, Animal; Garlic; Glutathione; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Phosphorus; Plant Extracts; Potassium; Rats; Rats, Wistar; Sodium; Urea	2015
Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016, Volume: 24, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Citrulline; Disease Models, Animal; Enteral Nutrition; Humans; Intestinal Mucosa; Male; Methotrexate; Mucositis; Rats; Rats, Wistar	2016
Can pretreatment serum calcium level predict the efficacy of methotrexate in the treatment of severe plaque psoriasis? Journal of the American Academy of Dermatology, 2015, Volume: 73, Issue:6 Topics: Adolescent; Adult; Aged; Animals; Area Under Curve; Biomarkers; Calcium; Cohort Studies; Disease Models, Animal; Female; Humans; Male; Methotrexate; Mice; Middle Aged; Predictive Value of Tests; Psoriasis; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult	2015
Direct chemotherapeutic dual drug delivery through intra-articular injection for synergistic enhancement of rheumatoid arthritis treatment. Scientific reports, 2015, 10-01, Volume: 5 Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Line; Chemistry, Pharmaceutical; Dexamethasone; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Immunohistochemistry; Injections, Intra-Articular; Male; Methotrexate; Mice; Rats; Spectroscopy, Near-Infrared; X-Ray Microtomography	2015
Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model. International journal of nanomedicine, 2015, Volume: 10 Topics: Animals; Arthritis, Rheumatoid; Chronic Disease; Disease Models, Animal; Drug Carriers; Humans; Inflammation; Interferon-gamma; Interleukin-17; Lipids; Methotrexate; Nanocapsules; Rats; Synovial Membrane; T-Lymphocytes	2015
Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. Scientific reports, 2015, Nov-18, Volume: 5 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosomes; Caspases; Cell Line, Tumor; Disease Models, Animal; Humans; Leydig Cells; Male; Mercaptopurine; Methotrexate; Mice, Transgenic; Multidrug Resistance-Associated Proteins; Reactive Oxygen Species	2015
Anti-inflammatory effects of intravenous methotrexate associated with lipid nanoemulsions on antigen-induced arthritis. Clinics (Sao Paulo, Brazil), 2016, Volume: 71, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Injections, Intra-Articular; Joints; Leukocyte Count; Methotrexate; Nanoparticles; Neutrophils; Rabbits; Synovial Fluid; Synovial Membrane	2016
Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment. Purinergic signalling, 2016, Volume: 12, Issue:2 Topics: 5'-Nucleotidase; Adenosine Monophosphate; Animals; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Glioblastoma; Immunohistochemistry; Immunosuppressive Agents; Methotrexate; Rats; T-Lymphocytes; Tumor Escape; Tumor Microenvironment; Up-Regulation	2016
Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats. Journal of ethnopharmacology, 2016, May-13, Volume: 183 Topics: Animals; Disease Models, Animal; Female; Glutathione; Intestinal Mucosa; Methotrexate; Mucositis; Plant Preparations; Plant Roots; Plantaginaceae; Rats; Rats, Wistar; Rehmannia; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha; Weight Loss	2016
Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication. Irish journal of medical science, 2017, Volume: 186, Issue:2 Topics: Animals; Antioxidants; Caffeic Acids; Disease Models, Animal; Ethanol; Liver; Male; Methanol; Methotrexate; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley	2017
APL-1, an altered peptide ligand derived from heat-shock protein, alone or combined with methotrexate attenuates murine collagen-induced arthritis. Clinical and experimental medicine, 2017, Volume: 17, Issue:2 Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Heat-Shock Proteins; Immunologic Factors; Interleukin-10; Male; Methotrexate; Mice, Inbred DBA; Peptides; Severity of Illness Index; T-Lymphocytes, Regulatory; Treatment Outcome; Tumor Necrosis Factor-alpha	2017
Ultrasonographical assessment of implanted biodegradable device for long-term slow release of methotrexate into the vitreous. Experimental eye research, 2016, Volume: 148 Topics: Absorbable Implants; Animals; Biocompatible Materials; Chitosan; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Immunosuppressive Agents; Methotrexate; Polyesters; Rabbits; Retina; Ultrasonography; Vitreous Body	2016
Successful intestinal Echinococcus multilocularis oncosphere invasion and subsequent hepatic metacestode establishment in resistant RccHan™:WIST rats after pharmacological immunosuppression. Parasitology, 2016, Volume: 143, Issue:10 Topics: Animals; Dexamethasone; Disease Models, Animal; Disease Resistance; Echinococcosis; Echinococcosis, Hepatic; Echinococcus multilocularis; Immunosuppression Therapy; Immunosuppressive Agents; Intestines; Methotrexate; Ovum; Rats; Rats, Nude; Rats, Wistar; T-Lymphocytes	2016
Environmental enrichment protects against cognitive impairment following chemotherapy in an animal model. Behavioral neuroscience, 2016, Volume: 130, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Cognition Disorders; Disease Models, Animal; Drug Therapy; Environment; Female; Fluorouracil; Hippocampus; Methotrexate; Neurogenesis; Rats; Rats, Long-Evans; Spatial Memory	2016
Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats. Analytical and quantitative cytopathology and histopathology, 2016, Volume: 38, Issue:2 Topics: Animals; Antioxidants; Biomarkers; Cytoprotection; Disease Models, Animal; Gastrointestinal Hemorrhage; Glutathione Peroxidase; Intestinal Mucosa; Jejunal Diseases; Jejunum; Male; Malondialdehyde; Methotrexate; Necrosis; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Time Factors; Vitamin E	2016
Effective transdermal delivery of methotrexate through nanostructured lipid carriers in an experimentally induced arthritis model. Colloids and surfaces. B, Biointerfaces, 2016, Nov-01, Volume: 147 Topics: Administration, Cutaneous; Animals; Arthritis, Experimental; Cell Survival; Cytokines; Disease Models, Animal; Female; Humans; Inflammation; Lipids; Methotrexate; Nanostructures; Rats; Rats, Wistar	2016
18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Renal failure, 2016, Volume: 38, Issue:9 Topics: Acute Kidney Injury; Animals; Biomarkers; Carboxylic Ester Hydrolases; Disease Models, Animal; Gap Junctions; Glycyrrhetinic Acid; Heme Oxygenase (Decyclizing); Kidney; Lipid Peroxidation; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Up-Regulation	2016
Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver. Journal of immunology research, 2016, Volume: 2016 Topics: Animals; Arachidonate Lipoxygenases; Arthritis, Experimental; Biomarkers; C-Reactive Protein; Cytokines; Disease Models, Animal; Gene Expression Regulation; Inflammation Mediators; Liver; Male; Methotrexate; Organ Specificity; Rats; Serotonin; Severity of Illness Index; Time Factors; Transcriptome	2016
Effects of Methotrexate in a Rabbit Model of In-Stent Neoatherosclerosis: An Optical Coherence Tomography Study. Scientific reports, 2016, 09-20, Volume: 6 Topics: Animals; Atherosclerosis; Carotid Artery Diseases; Cytokines; Disease Models, Animal; Drug-Eluting Stents; Image Processing, Computer-Assisted; Immunohistochemistry; Inflammation; Male; Methotrexate; NF-kappa B; Rabbits; Reproducibility of Results; Stents; Tomography, Optical Coherence	2016
Scavenger Receptor-Mediated Targeted Treatment of Collagen-Induced Arthritis by Dextran Sulfate-Methotrexate Prodrug. Theranostics, 2017, Volume: 7, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dextran Sulfate; Disease Models, Animal; Histocytochemistry; Knee Joint; Macrophages; Methotrexate; Mice; Mice, Inbred DBA; Prodrugs; RAW 264.7 Cells; Receptors, Scavenger; Treatment Outcome	2017
Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating differentiated T cell localization, activation and chemokine production in established breast cancer. Clinical immunology (Orlando, Fla.), 2008, Volume: 128, Issue:2 Topics: Adenocarcinoma; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Antimetabolites, Antineoplastic; Chemokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Immunotherapy, Adoptive; Injections, Intraperitoneal; Injections, Intravenous; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lymphocyte Activation; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Transgenic; T-Cell Antigen Receptor Specificity; T-Lymphocytes, Cytotoxic; Thy-1 Antigens	2008
Pre-bled-young-rats in genotoxicity testing: a model for peripheral blood micronucleus assay. Regulatory toxicology and pharmacology : RTP, 2008, Volume: 52, Issue:2 Topics: Animals; Area Under Curve; Diethylnitrosamine; Disease Models, Animal; Hemorrhage; Male; Methotrexate; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Quercetin; Rats; Rats, Sprague-Dawley; Reticulocytes; Streptozocin; Time Factors; Zidovudine	2008
Methotrexate-loaded polymethylmethacrylate bone cement for local bone metastasis therapy: pilot animal study in the rabbit patellar groove. Chemotherapy, 2008, Volume: 54, Issue:5 Topics: Animals; Bone Cements; Bone Neoplasms; Disease Models, Animal; Methotrexate; Patella; Pilot Projects; Polymethyl Methacrylate; Prostheses and Implants; Rabbits	2008
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model. Experimental parasitology, 2008, Volume: 120, Issue:3 Topics: Aminopterin; Animals; Antimalarials; Disease Models, Animal; Folic Acid Antagonists; Malaria; Male; Methotrexate; Mice; Mice, Inbred ICR; Parasitemia; Plasmodium berghei; Pteridines; Random Allocation	2008
Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. Pediatric surgery international, 2008, Volume: 24, Issue:12 Topics: Animals; Caco-2 Cells; Cell Proliferation; Disease Models, Animal; Enterocytes; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Methotrexate; Mucositis; Noxae; Rats; Rats, Sprague-Dawley; Recovery of Function; Transforming Growth Factor alpha	2008
Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. Cancer biology & therapy, 2009, Volume: 8, Issue:10 Topics: Animals; Annexin A5; Apoptosis; bcl-2-Associated X Protein; Caco-2 Cells; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Enterocytes; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ileum; Intestinal Mucosa; Jejunum; Leptin; Male; Methotrexate; Mucositis; Organ Size; Random Allocation; Rats; Rats, Sprague-Dawley; Recovery of Function; RNA, Messenger; Time Factors	2009
Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats. Behavioural brain research, 2009, Aug-12, Volume: 201, Issue:2 Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Association Learning; Cell Death; Cell Proliferation; Cognition; Cognition Disorders; Conditioning, Classical; Disease Models, Animal; Fear; Follow-Up Studies; Hippocampus; Maze Learning; Methotrexate; Rats; Rats, Wistar; Time Factors	2009
Locomotion and muscle mass measures in a murine model of collagen-induced arthritis. BMC musculoskeletal disorders, 2009, Jun-03, Volume: 10 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Body Weight; Cachexia; Disability Evaluation; Disease Models, Animal; Disease Progression; Gait Disorders, Neurologic; Image Processing, Computer-Assisted; Locomotion; Male; Methotrexate; Mice; Mice, Inbred DBA; Muscle, Skeletal; Muscular Atrophy; Severity of Illness Index; Treatment Outcome; Video Recording	2009
Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer. International journal of cancer, 2010, Jan-01, Volume: 126, Issue:1 Topics: Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Disease Progression; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Metastasis; Survival Analysis	2010
Therapeutic and preventive effects of methotrexate on zymosan-induced arthritis in SKG mice. The Journal of veterinary medical science, 2009, Volume: 71, Issue:6 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Female; Immunohistochemistry; Methotrexate; Mice; Mice, Inbred BALB C; Random Allocation	2009
Ozone ameliorates methotrexate-induced intestinal injury in rats. Cancer biology & therapy, 2009, Volume: 8, Issue:17 Topics: Animals; Disease Models, Animal; Glutathione Peroxidase; Ileum; Intestinal Diseases; Kidney; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Ozone; Rats	2009
Dietary zinc supplementation and methotrexate-induced small intestinal mucositis in metallothionein-knockout and wild-type mice. Cancer biology & therapy, 2009, Volume: 8, Issue:17 Topics: Animals; Dietary Supplements; Disease Models, Animal; Intestine, Small; Male; Metallothionein; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucositis; Zinc	2009
Optimization of the non-invasive 13C-sucrose breath test in a rat model of methotrexate-induced mucositis. Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Breath Tests; Carbon Isotopes; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Female; Intestine, Small; Methotrexate; Mucositis; Organ Size; Rats; Sensitivity and Specificity; Sucrase; Sucrose	2010
Treatment of adjuvant-induced arthritis with the combination of methotrexate and probiotic bacteria Escherichia coli O83 (Colinfant). Folia microbiologica, 2009, Volume: 54, Issue:4 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Combined Modality Therapy; Disease Models, Animal; Escherichia coli; Humans; Male; Methotrexate; Probiotics; Rats; Rats, Inbred Lew	2009
Effects of methotrexate on plasma cytokines and cardiac remodeling and function in postmyocarditis rats. Mediators of inflammation, 2009, Volume: 2009 Topics: Animals; Collagen Type I; Collagen Type III; Cytokines; Disease Models, Animal; Heart; Immunosuppressive Agents; Interleukin-10; Interleukin-6; Male; Methotrexate; Myocarditis; Rats; Rats, Inbred Lew; Swine; Tumor Necrosis Factor-alpha; Ventricular Remodeling	2009
Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma. The Journal of rheumatology, 2010, Volume: 37, Issue:3 Topics: Animals; Antirheumatic Agents; Bleomycin; Disease Models, Animal; Fibrosis; Injections, Intraperitoneal; Methotrexate; Mice; Mice, Inbred BALB C; Scleroderma, Systemic; Skin; Treatment Outcome	2010
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine. Pharmacology, biochemistry, and behavior, 2010, Volume: 95, Issue:4 Topics: Animals; Antimetabolites, Antineoplastic; Behavior, Animal; Cisterna Magna; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Homocysteine; Inflammation Mediators; Injections, Spinal; Male; Memory Disorders; Methotrexate; Motor Activity; Neuropsychological Tests; Psychomotor Performance; Rats; Rats, Long-Evans; Recognition, Psychology; Time Factors	2010
Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite. Parasitology research, 2010, Volume: 107, Issue:2 Topics: Animals; Anthelmintics; Autopsy; Body Weight; Cytostatic Agents; Disease Models, Animal; Echinococcosis; Echinococcus multilocularis; Female; Gerbillinae; Magnetic Resonance Imaging; Male; Methotrexate; Vinblastine; Vincristine; Vinorelbine	2010
Efficacy study of vesicular gel containing methotrexate and menthol combination on parakeratotic rat skin model. Journal of liposome research, 2011, Volume: 21, Issue:2 Topics: Administration, Topical; Animals; Dermatologic Agents; Diffusion Chambers, Culture; Disease Models, Animal; Drug Combinations; Drug Synergism; Gels; Humans; Immunodiffusion; Liposomes; Male; Menthol; Methotrexate; Parakeratosis; Permeability; Psoriasis; Rats; Rats, Wistar; Skin; Skin Absorption; Tissue Culture Techniques	2011
Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro. The Journal of toxicological sciences, 2010, Volume: 35, Issue:5 Topics: Animals; Apoptosis; Blood Cell Count; Bone Marrow; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Fibroblasts; Hydroxyproline; Immunohistochemistry; In Situ Nick-End Labeling; Lung; Male; Methotrexate; Mice; Mice, Inbred C57BL; Pulmonary Alveoli; Pulmonary Fibrosis	2010
Investigation of kinetics of methotrexate for therapeutic treatment of intraocular lymphoma. Current eye research, 2010, Volume: 35, Issue:12 Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Eye Neoplasms; Humans; Immunosuppressive Agents; Lymphoma; Methotrexate; Models, Biological; Rabbits; Treatment Outcome; Vitreous Body	2010
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proceedings of the National Academy of Sciences of the United States of America, 2010, Nov-09, Volume: 107, Issue:45 Topics: Animals; Arthritis; Cytokines; Disease Models, Animal; DNA; Endodeoxyribonucleases; Lymphocytes; Macrophages; Methotrexate; Mice; Mice, Knockout	2010
Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resveratrol. Neuro endocrinology letters, 2010, Volume: 31 Suppl 2 Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Cell Line; Disease Models, Animal; Drug Therapy, Combination; Macrophages; Male; Methotrexate; Neutrophils; Nitric Oxide; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Resveratrol; Stilbenes	2010
Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivo. Neuro endocrinology letters, 2010, Volume: 31 Suppl 2 Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Carnosine; Disease Models, Animal; Free Radicals; Glutathione; Hyaluronic Acid; In Vitro Techniques; Male; Methotrexate; Oxidation-Reduction; Protein Carbonylation; Rats; Rats, Inbred Lew; Thiobarbituric Acid Reactive Substances	2010
The effect of methotrexate on corneal neovascularization in rabbits. Cornea, 2011, Volume: 30, Issue:4 Topics: Administration, Topical; Animals; Antimetabolites, Antineoplastic; Cornea; Corneal Neovascularization; Disease Models, Animal; Interleukin-6; Methotrexate; Rabbits; Treatment Outcome; Vascular Endothelial Growth Factor A	2011
Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow. Journal of cellular physiology, 2012, Volume: 227, Issue:3 Topics: Adipocytes; Adipogenesis; Animals; Antimetabolites, Antineoplastic; Bone Diseases, Metabolic; Bone Marrow Cells; Cell Differentiation; Disease Models, Animal; Male; Methotrexate; Osteogenesis; Rats; Rats, Sprague-Dawley; Stem Cells	2012
Intestinal inflammation influences α-MSH reactive autoantibodies: relevance to food intake and body weight. Psychoneuroendocrinology, 2012, Volume: 37, Issue:1 Topics: alpha-MSH; Animals; Anorexia; Autoantibodies; Body Weight; Disease Models, Animal; Drinking; Eating; Humans; Immunoglobulin G; Male; Methotrexate; Mucositis; Rabbits; Rats; Rats, Sprague-Dawley	2012
Targeted dendrimer chemotherapy in an animal model for head and neck squamous cell carcinoma. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:9 Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Dendrimers; Disease Models, Animal; Female; Folate Receptor 1; Head and Neck Neoplasms; Humans; Methotrexate; Mice; Mice, SCID; Molecular Targeted Therapy; Neoplasm Transplantation	2011
Synergistic activity of curcumin with methotrexate in ameliorating Freund's Complete Adjuvant induced arthritis with reduced hepatotoxicity in experimental animals. European journal of pharmacology, 2011, Oct-01, Volume: 668, Issue:1-2 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis, Experimental; Aspartate Aminotransferases; Bilirubin; Curcumin; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Freund's Adjuvant; Lipid Peroxidation; Liver; Methotrexate; Organ Size; Rats; Rats, Wistar	2011
Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition Disorders; Cues; Disease Models, Animal; Donepezil; Female; Fluorouracil; Indans; Maze Learning; Memory; Methotrexate; Mice; Mice, Inbred BALB C; Nootropic Agents; Piperidines; Space Perception; Time Factors	2011
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist. Behavioural brain research, 2011, Dec-01, Volume: 225, Issue:2 Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology	2011
Protective effect of pentoxyfilline in renal toxicity after methotrexate administration. European review for medical and pharmacological sciences, 2011, Volume: 15, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Blood Urea Nitrogen; Creatinine; Cytoprotection; Disease Models, Animal; Glutathione Peroxidase; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Pentoxifylline; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha	2011
Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4⁺ T cells (Th17) cells in collagen-induced arthritis. Clinical & developmental immunology, 2012, Volume: 2012 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; CD4 Antigens; Collagen Type I; Disease Models, Animal; Disease Progression; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Immunomodulation; Immunotherapy; Interleukin-17; Joints; Methotrexate; Mice; Mice, Inbred DBA; Polymerization; T-Lymphocytes, Regulatory; Th17 Cells	2012
Methothrexate attenuates early neutrophil infiltration and the associated lipid peroxidation in the injured spinal cord but does not induce neurotoxicity in the uninjured spinal cord in rats. Acta neurochirurgica, 2012, Volume: 154, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Immunosuppressive Agents; Lipid Peroxidation; Methotrexate; Neutrophil Infiltration; Rats; Rats, Wistar; Spinal Cord Injuries	2012
Facial symmetry evaluation after experimentally displaced condylar process fracture in methotrexate treated rats. Acta cirurgica brasileira, 2012, Volume: 27, Issue:3 Topics: Analysis of Variance; Animals; Body Weight; Cephalometry; Disease Models, Animal; Facial Asymmetry; Immunosuppressive Agents; Joint Dislocations; Male; Mandibular Condyle; Mandibular Fractures; Maxilla; Methotrexate; Radiography; Random Allocation; Rats; Rats, Wistar; Temporomandibular Joint Disorders	2012
The effects of chemotherapy on cognitive function in a mouse model: a prospective study. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jun-01, Volume: 18, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition; Disease Models, Animal; Female; Fluorouracil; Learning; Longitudinal Studies; Memory; Methotrexate; Mice; Mice, Inbred BALB C; Neuropsychological Tests; Prospective Studies; Time Factors	2012
Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Arthritis research & therapy, 2012, Apr-30, Volume: 14, Issue:2 Topics: Animals; Arthritis, Experimental; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Interleukin-6; Male; Methotrexate; Mice; Mice, Inbred DBA; Reduced Folate Carrier Protein; Treatment Outcome	2012
Non-Fas(CD95/APO1)-mediated apoptosis of activated T cells inhibits the development of atherosclerosis. Interactive cardiovascular and thoracic surgery, 2012, Volume: 15, Issue:3 Topics: Animals; Aorta, Thoracic; Apoptosis; Atherosclerosis; Cholesterol; Disease Models, Animal; fas Receptor; Immunity, Cellular; Immunomodulation; Immunosuppressive Agents; Male; Methotrexate; Mice; Mice, Inbred C57BL; Prognosis	2012
Immunomodulatory effect of sertraline in a rat model of rheumatoid arthritis. Neuroimmunomodulation, 2012, Volume: 19, Issue:5 Topics: Analysis of Variance; Animals; Arthritis, Rheumatoid; Concanavalin A; Cyclooxygenase 2; Cytokines; Cytotoxicity Tests, Immunologic; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Immunologic Factors; Methotrexate; Rats; Rats, Inbred Lew; Sertraline; Spleen; Thymidine	2012
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance. Life sciences, 2012, Sep-17, Volume: 91, Issue:7-8 Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; Cells, Cultured; Cilostazol; Cytokines; Disease Models, Animal; DNA Primers; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Male; Methotrexate; Mice; Mice, Inbred DBA; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles	2012
Inhibition of sumoylation prevents experimental fibrosis. Annals of the rheumatic diseases, 2012, Volume: 71, Issue:11 Topics: Adolescent; Adult; Animals; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Humans; Immunosuppressive Agents; Keratinocytes; Male; Methotrexate; Mice; Middle Aged; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Scleroderma, Systemic; Signal Transduction; Skin; Smad3 Protein; SUMO-1 Protein; Sumoylation; Ubiquitin-Conjugating Enzymes; Young Adult	2012
Acute and chronic inflammation studies of Strobilanthes callosus leaves extract on rat model. Inflammopharmacology, 2013, Volume: 21, Issue:3 Topics: Acanthaceae; Acute Disease; Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents; Carrageenan; Chronic Disease; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Methotrexate; Plant Extracts; Plant Leaves; Prednisolone; Rats; Rats, Wistar; Solvents	2013
Effects of shark cartilage polysaccharides on the secretion of IL-6 and IL-12 in rheumatoid arthritis. Pharmaceutical biology, 2012, Volume: 50, Issue:12 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Arthrography; Cartilage; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation Mediators; Interleukin-12; Interleukin-6; Joints; Macrophages, Peritoneal; Male; Methotrexate; Polysaccharides; Rats; Rats, Wistar; Sharks; Time Factors	2012
The role of zinc on anti-Newcastle disease virus specific antibody response and agranulocytes count in rabbits treated with methotrexate and prednisolone. Pakistan journal of pharmaceutical sciences, 2012, Volume: 25, Issue:4 Topics: Administration, Oral; Animals; Antibodies, Viral; Disease Models, Animal; Female; Granulocytes; Immunosuppressive Agents; Injections, Subcutaneous; Leukocyte Count; Male; Methotrexate; Newcastle disease virus; Prednisolone; Rabbits; Time Factors; Viral Vaccines; Zinc	2012
Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat. Pediatric surgery international, 2013, Volume: 29, Issue:2 Topics: Abortifacient Agents, Nonsteroidal; Analysis of Variance; Animals; Apoptosis; Blotting, Western; Disease Models, Animal; In Situ Nick-End Labeling; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Spermatogenesis; Spermatozoa	2013
Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study. Journal of medical primatology, 2013, Volume: 42, Issue:2 Topics: Animals; Antimalarials; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Malaria; Male; Methotrexate; Papio anubis; Parasitemia; Plasmodium knowlesi	2013
A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats. PloS one, 2013, Volume: 8, Issue:1 Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Humans; Inflammation; Longitudinal Studies; Lymphocytes; Male; Methotrexate; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Rituximab; Tumor Necrosis Factor-alpha; Up-Regulation	2013
Effects of methotrexate upon inflammatory parameters induced by carrageenan in the mouse model of pleurisy. Mediators of inflammation, 2002, Volume: 11, Issue:5 Topics: Adenosine Deaminase; Animals; Carrageenan; Disease Models, Animal; Female; Immunosuppressive Agents; Male; Methotrexate; Mice; Nitric Oxide; Peroxidase; Pleura; Pleurisy	2002
Decreased activity of hepatic P-glycoprotein in the isolated perfused liver of the adjuvant arthritis rat. Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Disease Models, Animal; Doxorubicin; Female; Kinetics; Liver; Methotrexate; Perfusion; Rats; Rats, Inbred Lew; Time Factors	2002
Evaluation of the protective effect of methotrexate on OK432-induced liver injury in a rat model. Pediatric surgery international, 2003, Volume: 19, Issue:1-2 Topics: Animals; Chi-Square Distribution; Cholangitis; Disease Models, Animal; Methotrexate; Picibanil; Rats; Statistics, Nonparametric	2003
Effect of immunostimulatory ribomunyl on the preventive treatment of rat adjuvant arthritis with cyclosporine and methotrexate. The Journal of rheumatology, 2003, Volume: 30, Issue:9 Topics: Administration, Oral; Animals; Antigens, Bacterial; Arthritis, Experimental; Cyclosporine; Disease Models, Animal; Drug Therapy, Combination; Immunosuppressive Agents; Inflammation Mediators; Male; Methotrexate; Random Allocation; Rats; Rats, Inbred Lew; Reference Values; Sensitivity and Specificity; Treatment Outcome	2003
Translocation model of Candida albicans in DBA-2/J mice with protein calorie malnutrition mimics hematogenous candidiasis in humans. Microbial pathogenesis, 2003, Volume: 35, Issue:5 Topics: Animals; Candida albicans; Candidiasis; Cyclophosphamide; Disease Models, Animal; Feces; Female; Fungemia; Humans; Immunosuppressive Agents; Intestinal Mucosa; Intestines; Leukopenia; Liver; Methotrexate; Mice; Mice, Inbred DBA; Protein-Energy Malnutrition; Specific Pathogen-Free Organisms	2003
Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis. The Journal of rheumatology, 2003, Volume: 30, Issue:10 Topics: Animals; Arthritis, Experimental; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Enzyme-Linked Immunosorbent Assay; Female; Hindlimb; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Methotrexate; Rats; Rats, Inbred Lew; Tacrolimus; Tumor Necrosis Factor-alpha	2003
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood, 2004, May-15, Volume: 103, Issue:10 Topics: Adolescent; Animals; Antineoplastic Agents; Child; Child, Preschool; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gene Rearrangement, T-Lymphocyte; Genes, Immunoglobulin; Humans; Immunophenotyping; Male; Methotrexate; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Treatment Outcome; Vincristine	2004
Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis. Digestive diseases and sciences, 2004, Volume: 49, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Disease Models, Animal; Dose-Response Relationship, Drug; Duodenum; Eating; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methotrexate; Potassium; Rats; Rats, Wistar; Sodium; Stomatitis; Water; Weight Loss	2004
Effect of MX-68 on airway inflammation and hyperresponsiveness in mice and guinea-pigs. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2 Topics: 2-Aminoadipic Acid; Acetylcholine; Administration, Inhalation; Allergens; Animals; Body Weight; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Immunoglobulins; Injections, Intraperitoneal; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Methotrexate; Mice; Mice, Inbred BALB C; Ovalbumin; Prednisolone	2004
Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation. Digestive diseases and sciences, 2004, Volume: 49, Issue:3 Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Caco-2 Cells; Cell Division; Cells, Cultured; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Female; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Intestinal Mucosa; Lactoferrin; Methotrexate; Peptides; Polymerase Chain Reaction; Rats; Rats, Inbred Strains	2004
Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX. Rheumatology (Oxford, England), 2004, Volume: 43, Issue:9 Topics: Animals; Antibodies; Antigens, CD; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Collagen Type II; Disease Models, Animal; Drug Administration Schedule; Drug Carriers; Drug Combinations; Drug Synergism; Flow Cytometry; Humans; Injections, Intravenous; Leukocytes, Mononuclear; Male; Methotrexate; Mice; Mice, Inbred DBA; Serum Albumin; Treatment Outcome	2004
Treatment with immunosuppressive and anti-inflammatory agents delays onset of canine genetic narcolepsy and reduces symptom severity. Experimental neurology, 2004, Volume: 188, Issue:2 Topics: Age of Onset; Animals; Anti-Inflammatory Agents; Azathioprine; Disease Models, Animal; Disease Progression; Dogs; Female; Glucocorticoids; Immunosuppressive Agents; Male; Methotrexate; Methylprednisolone; Narcolepsy; Nucleic Acid Synthesis Inhibitors; Severity of Illness Index; Sleep; Time Factors; Treatment Outcome	2004
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis and rheumatism, 2004, Volume: 50, Issue:8 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Collagen; Disease Models, Animal; Endopeptidases; Fluorescence; Histocytochemistry; Male; Methotrexate; Mice; Mice, Inbred DBA; Sensitivity and Specificity; Treatment Outcome	2004
Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis. Annals of the rheumatic diseases, 2005, Volume: 64, Issue:4 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Female; Fibroblasts; Immunosuppressive Agents; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID	2005
Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology. Arthritis and rheumatism, 2004, Volume: 50, Issue:10 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Interleukin-1; Interleukin-6; Joints; Male; Methotrexate; Mice; Mice, Inbred DBA; p38 Mitogen-Activated Protein Kinases; Prednisolone; Terpenes; Tumor Necrosis Factor-alpha	2004
A novel breath test for the non-invasive assessment of small intestinal mucosal injury following methotrexate administration in the rat. Scandinavian journal of gastroenterology, 2004, Volume: 39, Issue:10 Topics: Analysis of Variance; Animals; Breath Tests; Disease Models, Animal; Injections, Subcutaneous; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Sucrose	2004
Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions. Drug metabolism and pharmacokinetics, 2004, Volume: 19, Issue:5 Topics: Animals; Anions; Area Under Curve; ATP-Binding Cassette Transporters; Blood Proteins; Creatine Kinase; Disease Models, Animal; Folic Acid Antagonists; Half-Life; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperbilirubinemia; Male; Methotrexate; Muscle, Skeletal; Pravastatin; Protein Binding; Rats; Rats, Inbred Strains; Toxicity Tests; Weight Gain	2004
[The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2004, Volume: 25, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Interleukin-11; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Microscopy, Electron; Mucositis; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Wistar; Survival Rate	2004
Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer research, 2005, Jun-15, Volume: 65, Issue:12 Topics: Animals; Antineoplastic Agents; Carrier Proteins; Dendrimers; Disease Models, Animal; Drug Carriers; Female; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Humans; KB Cells; Methotrexate; Mice; Mice, Nude; Mice, SCID; Nanostructures; Polyamines; Radiopharmaceuticals; Receptors, Cell Surface; Tissue Distribution; Tritium; Xenograft Model Antitumor Assays	2005
Application of anti-methotrexate Fab fragments for the optimization of intraperitoneal methotrexate therapy in a murine model of peritoneal cancer. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:9 Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Area Under Curve; Body Weight; Combined Modality Therapy; Disease Models, Animal; Half-Life; Immunoglobulin Fab Fragments; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Mice; Peritoneal Neoplasms; Sarcoma 180; Survival Rate	2005
Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation. Arthritis and rheumatism, 2005, Volume: 52, Issue:8 Topics: Acute Disease; Adenosine; Air; Animals; Anti-Inflammatory Agents; Carrageenan; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Exudates and Transudates; Inbreeding; Inflammation; Injections, Subcutaneous; Methotrexate; Mice; Mice, Inbred Strains; Osmolar Concentration; Phenotype; Quantitative Trait Loci	2005
Abatacept: a costimulatory inhibitor for treatment of rheumatoid arthritis. Expert opinion on biological therapy, 2005, Volume: 5, Issue:9 Topics: Abatacept; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Models, Animal; Drug Therapy, Combination; Humans; Immunoconjugates; Immunologic Factors; Infusions, Intravenous; Lymphocyte Activation; Methotrexate; Randomized Controlled Trials as Topic; T-Lymphocytes	2005
M-VAC regimen in murine bladder tumors. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease Models, Animal; Doxorubicin; Female; Methotrexate; Mice; Mice, Inbred C3H; Urinary Bladder Neoplasms; Vinblastine	1989
Methotrexate causes oxidative stress in rat kidney tissues. Renal failure, 2005, Volume: 27, Issue:6 Topics: Animals; Biomarkers; Disease Models, Animal; Female; Glutathione Peroxidase; Infusions, Intravenous; Kidney; Lipid Peroxidation; Malondialdehyde; Methotrexate; Oxidative Stress; Probability; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Superoxide Dismutase; Tissue Culture Techniques	2005
Artemether: a new therapeutic strategy in experimental rheumatoid arthritis. Immunopharmacology and immunotoxicology, 2005, Volume: 27, Issue:4 Topics: Animals; Antibodies; Antimalarials; Antirheumatic Agents; Artemether; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Cell Line, Tumor; Cell Survival; Collagen Type II; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Injections, Intramuscular; Injections, Intraperitoneal; Joints; Male; Matrix Metalloproteinase 2; Methotrexate; Mice; Nitric Oxide; Rats; Rats, Inbred Lew; Time Factors	2005
The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1 Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cytarabine; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Gemcitabine; Humans; In Vitro Techniques; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Mice, SCID; Time Factors; Xenograft Model Antitumor Assays	2006
Low-dose methotrexate inhibits lung metastasis and lengthens survival in rat osteosarcoma. Clinical & experimental metastasis, 2005, Volume: 22, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Rats; Rats, Inbred F344; Survival Analysis	2005
Methotrexate reduces the complications of endophthalmitis resulting from intravitreal injection compared with dexamethasone in a rabbit model. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:4 Topics: Animals; Colony Count, Microbial; Dexamethasone; Disease Models, Animal; Endophthalmitis; Eye Infections, Bacterial; Folic Acid Antagonists; Glucocorticoids; Injections; Methotrexate; Microbial Sensitivity Tests; Rabbits; Staphylococcal Infections; Staphylococcus epidermidis; Vitreous Body	2006
Seizure-promoting effect of blood-brain barrier disruption. Epilepsia, 2007, Volume: 48, Issue:4 Topics: Adult; Animals; Antineoplastic Agents; Biomarkers; Blood-Brain Barrier; Brain; Brain Neoplasms; Cerebrovascular Disorders; Disease Models, Animal; Electroencephalography; Female; Functional Laterality; Humans; Infusions, Intra-Arterial; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Osmotic Pressure; S100 Proteins; Seizures; Swine; Tomography, X-Ray Computed; Treatment Outcome	2007
Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. Journal of molecular medicine (Berlin, Germany), 2007, Volume: 85, Issue:5 Topics: Adolescent; Adult; Amides; Animals; Arachidonic Acids; Atrophy; Cannabinoid Receptor Modulators; Case-Control Studies; Celiac Disease; Child; Diet, Protein-Restricted; Disease Models, Animal; Duodenum; Endocannabinoids; Ethanolamines; Female; Glycerides; Humans; Jejunum; Male; Methotrexate; Middle Aged; Palmitic Acids; Peroxidase; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Time Factors; Up-Regulation	2007
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:5 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Cell Membrane; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Male; Membrane Potentials; Membrane Transport Proteins; Methotrexate; Mice; Mice, Inbred C57BL; Microvilli; Molecular Sequence Data; Oocytes; Polyglutamic Acid; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Proton-Coupled Folate Transporter; Rats; RNA, Messenger; Tetrahydrofolates; Xenopus	2007
Immune tolerance induction to enzyme-replacement therapy by co-administration of short-term, low-dose methotrexate in a murine Pompe disease model. Clinical and experimental immunology, 2008, Volume: 152, Issue:1 Topics: alpha-Glucosidases; Animals; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Glycogen Storage Disease Type II; Immune Tolerance; Immunoglobulin G; Immunosuppressive Agents; Injections, Intraperitoneal; Injections, Intravenous; Male; Methotrexate; Mice; Mice, Knockout; Recombinant Proteins	2008
Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease. International immunopharmacology, 2008, Volume: 8, Issue:6 Topics: Acute Disease; Animals; Antibodies; CD3 Complex; Chronic Disease; Colitis; Cyclosporine; Dextran Sulfate; Disease Models, Animal; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Interleukin-12 Subunit p40; Methotrexate; Mice; Mice, Inbred C57BL	2008
Gene expression profiles of murine fatty liver induced by the administration of methotrexate. Toxicology, 2008, Jul-10, Volume: 249, Issue:1 Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Liver; Gene Expression; Gene Expression Profiling; Lipid Metabolism; Male; Methotrexate; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Toxicogenetics	2008
Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model. Current eye research, 1984, Volume: 3, Issue:4 Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Eye Diseases; Female; Fibroblasts; Fluorouracil; Male; Methotrexate; Rabbits; Retinal Detachment; Retinal Diseases; Triamcinolone; Trifluridine; Vitreous Body	1984
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth. The American journal of clinical nutrition, 1981, Volume: 34, Issue:4 Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrexate; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Rats; Tyrosine	1981
Systemic chemotherapy of murine bladder cancer. Urology, 1984, Volume: 23, Issue:4 Suppl Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Etoposide; FANFT; Female; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Urinary Bladder Neoplasms	1984
The Nb rat prostatic adenocarcinoma's dose response to methotrexate and adriamycin. Journal of surgical oncology, 1983, Volume: 24, Issue:3 Topics: Adenocarcinoma; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Male; Methotrexate; Neoplasm Metastasis; Prostatic Neoplasms; Rats	1983
An experimental model to determine the effects of adjuvant therapy on the incidence of postoperative wound infection: II. Evaluating preoperative chemotherapy. Plastic and reconstructive surgery, 1980, Volume: 65, Issue:3 Topics: Animals; Disease Models, Animal; Head and Neck Neoplasms; Humans; Lethal Dose 50; Leucovorin; Leukocyte Count; Male; Methotrexate; Preoperative Care; Radiotherapy, High-Energy; Rats; Staphylococcal Infections; Surgical Wound Infection; Time Factors; Wound Healing	1980
Chemotherapy of pancreatic adenocarcinoma: initial report on two transplantable models in the Syrian hamster. Cancer research, 1982, Volume: 42, Issue:7 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Cyclophosphamide; Disease Models, Animal; Fluorouracil; Guinea Pigs; Male; Mesocricetus; Methotrexate; Mitomycin; Mitomycins; Neoplasms, Experimental; Pancreatic Neoplasms; Vincristine	1982
Chemoimmunotherapy of murine bladder cancer. Investigative urology, 1981, Volume: 19, Issue:3 Topics: Animals; BCG Vaccine; Carcinoma, Transitional Cell; Cyclophosphamide; Disease Models, Animal; Drug Therapy, Combination; Female; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Urinary Bladder Neoplasms	1981
Tissue distribution of methotrexate following administration as a solution and as a magnetic microsphere conjugate in rats bearing brain tumors. Journal of neuro-oncology, 1995, Volume: 24, Issue:2 Topics: Animals; Brain Neoplasms; Disease Models, Animal; Drug Delivery Systems; Evaluation Studies as Topic; Glioma; Magnetics; Male; Methotrexate; Microspheres; Rats; Rats, Inbred F344; Solutions; Tissue Distribution	1995
[Studies on biphasic animal model of asthma--lymphocytes and eosinophils]. Nihon Kyobu Shikkan Gakkai zasshi, 1993, Volume: 31 Suppl Topics: Animals; Asthma; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Lymphocytes; Methotrexate	1993
Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia. Pediatric research, 1994, Volume: 35, Issue:2 Topics: Animals; Behavior, Animal; Brain; Child; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Humans; Leukemia, Experimental; Male; Methotrexate; Nervous System; Prednisolone; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley	1994
In vivo experimental models on the evaluation of haemoperfusion. Bollettino della Societa italiana di biologia sperimentale, 1993, Volume: 69, Issue:10 Topics: Alkalosis; Animals; Chlorides; Disease Models, Animal; Female; Hemoperfusion; Male; Methotrexate; Partial Thromboplastin Time; Poisoning; Pyloric Stenosis; Rabbits; Swine; Uremia	1993
Suppression of adjuvant-induced arthritis by liposomally conjugated methotrexate in the rat. British journal of rheumatology, 1994, Volume: 33, Issue:6 Topics: Animals; Arthritis, Infectious; Disease Models, Animal; Drug Carriers; Liposomes; Male; Methotrexate; Mycobacterium; Phosphatidylethanolamines; Rats; Rats, Inbred Lew; Severity of Illness Index	1994
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. The Journal of clinical investigation, 1993, Volume: 92, Issue:6 Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors	1993
A rabbit model for the evaluation of minimal access treatment of ectopic pregnancy in humans, using intrachorionic injection and local hyperthermia. Clinical and experimental obstetrics & gynecology, 1993, Volume: 20, Issue:4 Topics: Abortifacient Agents; Abortion, Therapeutic; Animals; Carbon Dioxide; Chorion; Decidua; Disease Models, Animal; Female; Fever; Hysterectomy; Injections; Methotrexate; Microscopy, Electron; Ornipressin; Pregnancy; Pregnancy, Ectopic; Progesterone; Rabbits; Sodium Chloride; Uterus	1993
Pharmacokinetics and biodistribution of methotrexate conjugated to mannosyl human serum albumin. The Journal of antimicrobial chemotherapy, 1993, Volume: 31, Issue:1 Topics: Animals; Disease Models, Animal; Humans; In Vitro Techniques; Leishmaniasis, Visceral; Liver; Macrophages; Mannose; Methotrexate; Mice; Mice, Inbred BALB C; Serum Albumin; Subcellular Fractions; Tissue Distribution	1993
The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain. Pharmaceutical research, 1995, Volume: 12, Issue:12 Topics: Animals; Brain Neoplasms; Disease Models, Animal; Male; Methotrexate; Microdialysis; Rats; Rhabdomyosarcoma	1995
Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats. The Journal of nutrition, 1997, Volume: 127, Issue:5 Topics: Administration, Oral; alpha-Glucosidases; Animals; Antimetabolites, Antineoplastic; Avitaminosis; Body Weight; Diarrhea; Disaccharides; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Food, Fortified; Incidence; Intestinal Mucosa; Jejunal Diseases; Jejunum; Liver; Male; Methotrexate; Rats; Rats, Wistar; Sucrase; Vitamin A	1997
Cytokine manipulation by methotrexate treatment in murine experimental systemic lupus erythematosus. The Journal of rheumatology, 1997, Volume: 24, Issue:6 Topics: Animals; Cytokines; Disease Models, Animal; Female; Immunosuppressive Agents; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-4; Lupus Erythematosus, Systemic; Methotrexate; Mice; Mice, Inbred BALB C	1997
Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE). International journal of immunopharmacology, 1997, Volume: 19, Issue:2 Topics: 2-Aminoadipic Acid; Age Factors; Animals; Autoantibodies; Blood Urea Nitrogen; Cholesterol; Chronic Disease; Disease Models, Animal; Female; Folic Acid Antagonists; Graft vs Host Disease; Lupus Erythematosus, Systemic; Lupus Nephritis; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred NZB; Proteinuria	1997
The effects of high-dose methotrexate on the development of cartilage lesions in a lapine model of osteoarthrosis. Archives of orthopaedic and trauma surgery, 1998, Volume: 117, Issue:4-5 Topics: Animals; Antirheumatic Agents; Cartilage, Articular; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Injections, Intramuscular; Knee Joint; Methotrexate; Osteoarthritis; Rabbits	1998
Effect of methotrexate on distraction osteogenesis. Clinical orthopaedics and related research, 1998, Issue:354 Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Bone Neoplasms; Bone Regeneration; Calcification, Physiologic; Calcium; Disease Models, Animal; External Fixators; Female; Humans; Ilizarov Technique; Methotrexate; Osteogenesis, Distraction; Osteosarcoma; Phosphorus; Placebos; Rabbits; Radiography; Random Allocation; Tibia	1998
DNA levels in immune complexes circulating in mice with induced systemic lupus erythematosus. Immunology letters, 1999, Apr-01, Volume: 67, Issue:2 Topics: Animals; Antigen-Antibody Complex; Disease Models, Animal; DNA; Female; Humans; Lupus Erythematosus, Systemic; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nucleic Acid Synthesis Inhibitors; Tamoxifen	1999
Methotrexate produces delayed emesis in dogs: a potential model of delayed emesis induced by chemotherapy. European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3 Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Dexamethasone; Disease Models, Animal; Dogs; Female; Male; Methotrexate; Ondansetron; Vomiting	1999
Interleukin-1beta (IL-1beta) inhibition: a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis. British journal of pharmacology, 1999, Volume: 128, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cattle; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Hindlimb; Interleukin-1; Lipopolysaccharides; Liposomes; Macrophages, Peritoneal; Methotrexate; Phosphatidylethanolamines; Rats; Rats, Inbred Lew; Time Factors	1999
Topical application of methotrexate for inhibition of corneal angiogenesis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1999, Volume: 237, Issue:11 Topics: Animals; Aqueous Humor; Cell Division; Corneal Neovascularization; Disease Models, Animal; Endothelium, Vascular; Fibroblast Growth Factors; Follow-Up Studies; Immunosuppressive Agents; Methotrexate; Ophthalmic Solutions; Rabbits; Treatment Outcome	1999
Polymer chemotherapy for head and neck cancer. The Laryngoscope, 2000, Volume: 110, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biodegradation, Environmental; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Cisplatin; Disease Models, Animal; Drug Carriers; Head and Neck Neoplasms; Humans; Methotrexate; Mice; Mice, Nude; Polymers	2000
Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica. Pain, 2000, Volume: 87, Issue:2 Topics: Animals; Disease Models, Animal; Genes, MHC Class II; Glial Fibrillary Acidic Protein; Hindlimb; Immunosuppressive Agents; Male; Methotrexate; Pain Threshold; Radiculopathy; Rats; Rats, Sprague-Dawley; Sciatica; Spinal Cord; Spinal Nerve Roots	2000
A preclinical model for experimental chemotherapy of human head and neck cancer. International journal of oncology, 2001, Volume: 18, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Body Weight; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Disease Models, Animal; Docetaxel; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Ifosfamide; Methotrexate; Mice; Mice, Nude; Paclitaxel; Survival Rate; Taxoids	2001
Simplified method of heterotopic rat heart transplantation using the cuff technique: application to sublethal dose protocol of methotrexate on allograft survival. Microsurgery, 2001, Volume: 21, Issue:1 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Graft Rejection; Graft Survival; Heart Transplantation; Male; Methotrexate; Microsurgery; Rats; Rats, Inbred Lew; Sensitivity and Specificity; Survival Rate; Transplantation Immunology; Transplantation, Heterologous	2001
MTX affects inflammation and tissue destruction differently in the rat AA model. The Journal of rheumatology, 2001, Volume: 28, Issue:7 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Joints; Methotrexate; Rats; Rats, Inbred Lew	2001
Polyglutamation of a novel antifolate, MX-68, is not necessary for its anti-arthritic effect. European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3 Topics: 2-Aminoadipic Acid; Animals; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Experimental; Cell Division; Cells, Cultured; Disease Models, Animal; Folic Acid Antagonists; Male; Methotrexate; Mice; Mice, Inbred DBA; Peptide Synthases; Polyglutamic Acid; Rats; Rats, Inbred Lew; Substrate Specificity; Tetrahydrofolate Dehydrogenase	2002
Transforming Growth Factor-beta2 protects the small intestine during methotrexate treatment in rats possibly by reducing stem cell cycling. British journal of cancer, 2002, Jul-01, Volume: 87, Issue:1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Atrophy; Cell Cycle; Cell Death; Disease Models, Animal; Epithelial Cells; Female; Immunosuppressive Agents; Intestine, Small; Methotrexate; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta2; Weight Loss	2002
Chemotherapeutic remissions in Wistar Furth rat acute myelogenous leukemia: a model for human AML. Acta haematologica, 1977, Volume: 57, Issue:4 Topics: Animals; Antineoplastic Agents; Busulfan; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Dexamethasone; Disease Models, Animal; Doxorubicin; Leukemia, Experimental; Leukemia, Myeloid, Acute; Methotrexate; Rats; Remission, Spontaneous; Vinblastine; Vincristine	1977
Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models. Cancer research, 1978, Volume: 38, Issue:2 Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Sarcoma 180; Time Factors	1978
[Effect of cyclophosphamide on experimental tuberculosis in mice]. Annales de microbiologie, 1978, Volume: 129, Issue:1 Topics: Acute Disease; Animals; BCG Vaccine; Chronic Disease; Cyclophosphamide; Disease Models, Animal; Isoniazid; Methotrexate; Mice; Mycobacterium bovis; Tuberculosis	1978
Approaches to graft-versus-host disease following bone marrow transplantation in monkeys and man. Transplantation proceedings, 1978, Volume: 10, Issue:1 Topics: Adult; Animals; Bone Marrow Transplantation; Cell Separation; Disease Models, Animal; Graft vs Host Disease; Haplorhini; Humans; Immunosuppression Therapy; Leukemia; Lymphocytes; Methotrexate; Middle Aged; Pulmonary Fibrosis; Transplantation, Autologous; Transplantation, Homologous	1978
The use of marmosets (Callithrix jacchus) in teratological and toxicological research. Primates in medicine, 1978, Volume: 10 Topics: Abnormalities, Drug-Induced; Animals; Callitrichinae; Disease Models, Animal; Female; Fetus; Haplorhini; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy, Animal; Research; Toxicology; Uterus	1978
Chemotherapy of experimental metastatic brain tumors in female Wistar rats. Cancer research, 1979, Volume: 39, Issue:7 Pt 1 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Carotid Arteries; Cells, Cultured; Cyclophosphamide; Disease Models, Animal; Female; Lomustine; Methotrexate; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosourea Compounds; Procarbazine; Rats; Semustine	1979
Treatment of meningeal neoplasms. Cancer treatment reports, 1977, Volume: 61, Issue:4 Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carcinoma 256, Walker; Catheterization; Child; Cytarabine; Disease Models, Animal; Drug Therapy, Combination; Humans; Injections, Intraventricular; Injections, Spinal; Leukemia; Lumbosacral Region; Meninges; Methotrexate; Rats; Spinal Cord Neoplasms	1977
New preclinical models for testing antitumor drugs. The immuno-chemotherapy index. Archiv fur Geschwulstforschung, 1978, Volume: 48, Issue:7 Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Disease Models, Animal; Doxorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Histocompatibility Antigens; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Isogeneic	1978
Nonessential role of neutrophils as mediators of hyperacute cardiac allograft rejection in the rat. Laboratory investigation; a journal of technical methods and pathology, 1976, Volume: 34, Issue:3 Topics: Animals; Blood Platelets; Cyclophosphamide; Disease Models, Animal; Globulins; Graft Rejection; Heart Transplantation; Hypersensitivity; Mast Cells; Methotrexate; Neutrophils; Rabbits; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Skin; Transplantation, Homologous	1976
Mouse myeloma. A model for studies of cell kinetics. Archives of internal medicine, 1975, Volume: 135, Issue:1 Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Bone Neoplasms; Cell Division; Cells, Cultured; Cyclophosphamide; Cytarabine; Disease Models, Animal; Kinetics; Melphalan; Methotrexate; Mice; Mice, Inbred BALB C; Myeloma Proteins; Neoplasms, Experimental; Plasmacytoma; Thymidine; Tritium; Vinblastine; Vincristine	1975
[Possibilities and limits of pre-therapeutic neoplasm sensitivity cytostatics tests under short-term conditions]. Schweizerische medizinische Wochenschrift, 1975, Jan-18, Volume: 105, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cyclophosphamide; Dactinomycin; Daunorubicin; Disease Models, Animal; DNA, Neoplasm; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Hydroxyurea; Male; Methotrexate; Mice; Procarbazine; Rats; RNA, Neoplasm; Time Factors; Triaziquone; Vincristine	1975
The role of neutrophils in acute and chronic inflammation in rats. African journal of medicine and medical sciences, 1992, Volume: 21, Issue:2 Topics: Acute Disease; Animals; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Animal; Edema; Freund's Adjuvant; Histamine; Inflammation; Leukocyte Count; Male; Methotrexate; Neutropenia; Neutrophils; Rats; Rats, Wistar	1992
Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. Archives of surgery (Chicago, Ill. : 1960), 1992, Volume: 127, Issue:11 Topics: Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Energy Intake; Glutamine; Humans; Male; Methotrexate; Rats; Rats, Inbred F344; Sarcoma, Experimental	1992
Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin. Agents and actions, 1992, Volume: 35, Issue:1-2 Topics: Aminopterin; Animals; Autoimmune Diseases; Blood Urea Nitrogen; Dermatitis; Disease Models, Animal; Female; Joints; Lymph Nodes; Methotrexate; Mice; Proteinuria	1992
Fatal systemic candidiasis of gastrointestinal origin: an experimental model in mice compromised by anti-cancer treatment. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1992, Volume: 30, Issue:3 Topics: Animals; Candida albicans; Candidiasis; Cecum; Chemotherapy, Adjuvant; Disease Models, Animal; Esophagus; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Diseases; Immunocompromised Host; Intestines; Liver; Methotrexate; Mice; Mice, Inbred ICR; Neoplasms; Stomach; Viscera	1992
[Experimental histological study of the local toxicity of intra-tubal injections of methotrexate]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1992, Volume: 21, Issue:1 Topics: Animals; Biopsy; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Infertility, Female; Inflammation; Injections; Injections, Subcutaneous; Methotrexate; Peritoneal Diseases; Pregnancy; Pregnancy, Tubal; Rabbits	1992
Efficacy of bimolane in the Malassezia ovalis model of psoriasis. The Journal of dermatology, 1991, Volume: 18, Issue:12 Topics: Administration, Cutaneous; Administration, Oral; Animals; Betamethasone Valerate; Disease Models, Animal; Female; Injections, Intravenous; Malassezia; Methotrexate; Psoriasis; Rabbits; Razoxane; Skin	1991
Inhibition of human renal cancer by monoclonal-anti-body-linked methotrexate in an ascites tumor model. Cancer immunology, immunotherapy : CII, 1991, Volume: 32, Issue:5 Topics: Animals; Antibodies, Monoclonal; Carcinoma, Ehrlich Tumor; Carcinoma, Renal Cell; Cell Division; Disease Models, Animal; Female; Humans; Immunoglobulin G; Immunotoxins; Kidney Neoplasms; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Tumor Cells, Cultured	1991
Effect of post-transplant methotrexate, cyclosporin A and prednisolone on graft rejection after allogeneic bone marrow transplantation. Bone marrow transplantation, 1991, Volume: 7, Issue:1 Topics: Administration, Oral; Animals; Bone Marrow Transplantation; Cyclosporins; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Graft Rejection; Graft vs Host Disease; Immunosuppression Therapy; Injections, Intraperitoneal; Methotrexate; Prednisolone; Rats; Rats, Inbred Lew; Whole-Body Irradiation	1991
Effect of the immune modulating agents cyclophosphamide, methotrexate, hydrocortisone, and cyclosporin A on an animal model of granulomatous bowel disease. Gut, 1990, Volume: 31, Issue:6 Topics: Adjuvants, Immunologic; Animals; Cyclophosphamide; Cyclosporins; Disease Models, Animal; Female; Granuloma; Guinea Pigs; Hydrocortisone; Ileal Diseases; Lymph Nodes; Methotrexate; Organ Size	1990
Effect of concentration and time of drug exposure on clonal growth of murine bladder cancer. Urology, 1985, Volume: 25, Issue:3 Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cisplatin; Colony-Forming Units Assay; Disease Models, Animal; Doxorubicin; FANFT; Female; Fluorouracil; Maytansine; Methotrexate; Mice; Mice, Inbred C3H; Mitomycin; Mitomycins; Podophyllotoxin; Streptozocin; Time Factors; Trichothecenes; Tumor Stem Cell Assay; Urinary Bladder Neoplasms	1985
Methotrexate in rheumatoid arthritis: studies with animal models. Advances in enzyme regulation, 1989, Volume: 29 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemotaxis, Leukocyte; Disease Models, Animal; Female; Histocompatibility Antigens Class II; Interleukin-1; Interleukin-2; Male; Methotrexate; Neutrophils; Rats; Rats, Inbred Lew; Spleen	1989
Experimental study on subacute neurotoxicity of methotrexate in cats. Acta neuropathologica, 1989, Volume: 78, Issue:3 Topics: Animals; Cats; Cerebrospinal Fluid; Demyelinating Diseases; Disease Models, Animal; Drug Synergism; Female; Male; Methotrexate; Necrosis; Neurotoxins; Risk Factors	1989
An animal model to detect the neuropsychological toxicity of anticancer agents. Medical and pediatric oncology, 1989, Volume: 17, Issue:3 Topics: Animals; Avoidance Learning; Brain; Cognition; Conditioning, Classical; Disease Models, Animal; Female; Learning; Male; Methotrexate; Rats; Rats, Inbred Lew; Taste	1989
New xenograft model for assessing experimental therapy of central nervous system tumors: human glioblastoma in the intrathecal compartment of the nude mouse. Neurosurgery, 1988, Volume: 22, Issue:5 Topics: Animals; Carmustine; Cell Line; Disease Models, Animal; Drug Screening Assays, Antitumor; Glioma; Humans; Injections, Intraperitoneal; Injections, Spinal; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms, Nerve Tissue; Spinal Cord; Time Factors; Transplantation, Heterologous	1988
Induction of hepatic veno-occlusive disease in dogs. The American journal of pathology, 1987, Volume: 126, Issue:1 Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography	1987
Studies on the effect of D-penicillamine, gold thioglucose and methotrexate on streptococcal cell wall arthritis. The Journal of rheumatology, 1986, Volume: 13, Issue:5 Topics: Animals; Arthritis, Infectious; Aurothioglucose; Cell Wall; Concanavalin A; Disease Models, Animal; Female; Gold; Interleukin-2; Methotrexate; Penicillamine; Rats; Rats, Inbred Lew; Spleen; Streptococcal Infections	1986
Preclinical trials using an immunoconjugate of T101 and methotrexate in an athymic mouse/human T-cell tumor model. Journal of biological response modifiers, 1988, Volume: 7, Issue:6 Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Disease Models, Animal; Humans; Immunotoxins; Methotrexate; Mice; Mice, Nude; Neoplasms, Experimental	1988
T lymphocyte line-mediated experimental allergic encephalomyelitis--a pharmacologic model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2 Topics: Animals; Autoimmune Diseases; Cell Line; Central Nervous System Diseases; Disease Models, Animal; Drug Tolerance; Encephalomyelitis; Female; Immunosuppressive Agents; Injections, Intraperitoneal; Injections, Intravenous; Methotrexate; Rats; Rats, Inbred Lew; T-Lymphocytes	1987
A preliminary report on the suitability of sheep epidermal squamous cell carcinoma as a solid tumor model in the evaluation of intra-arterial methotrexate administration. Journal of surgical oncology, 1986, Volume: 32, Issue:2 Topics: Animals; Carcinoma, Squamous Cell; Disease Models, Animal; DNA, Neoplasm; Epidermis; Flow Cytometry; Head and Neck Neoplasms; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Neoplasm Staging; Sheep; Skin Neoplasms	1986
The effect of low dose chronic intermittent parental methotrexate on delayed type hypersensitivity and acute inflammation in a mouse model. The Journal of rheumatology, 1986, Volume: 13, Issue:4 Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Hypersensitivity, Delayed; Immunosuppression Therapy; Inflammation; Methotrexate; Mice; Mice, Inbred BALB C; Time Factors	1986
Nb rat prostate adenocarcinoma model: evaluation of the subrenal capsular assay system. Journal of surgical oncology, 1985, Volume: 28, Issue:4 Topics: Adenocarcinoma; Animals; Cisplatin; Cyclophosphamide; Disease Models, Animal; Doxorubicin; Histological Techniques; Kidney Neoplasms; Male; Methotrexate; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Rats, Inbred Strains	1985
A two-stage therapeutic design in the spontaneous AKR lymphoma system. Cancer research, 1972, Volume: 32, Issue:6 Topics: Amides; Animals; Antineoplastic Agents; Azacitidine; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Female; Imidazoles; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Oxazines; Prednisone; Remission, Spontaneous; Time Factors; Triazenes; Vincristine	1972
In vitro studies of the cell-bound and antibody-mediated immunity evoked by murine renal allotransplants. Influence of presensitization, total body irradiation and immunosuppressive agents. Clinical and experimental immunology, 1973, Volume: 14, Issue:2 Topics: Animals; Antibody Formation; Antilymphocyte Serum; Azathioprine; Cells, Cultured; Dactinomycin; Disease Models, Animal; Female; Hot Temperature; Immunity, Cellular; Immunosuppressive Agents; Kidney; Kidney Transplantation; Leucovorin; Male; Methotrexate; Methylprednisolone; Radiation Effects; Rats; Thoracic Duct; Transplantation Immunology	1973
Intra-arterial infusion chemotherapy in head and neck cancer. A clinical and experimental study. Archivum chirurgicum Neerlandicum, 1973, Volume: 25, Issue:4 Topics: Animals; Carotid Artery, External; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Head; Head and Neck Neoplasms; Humans; Methods; Methotrexate; Neoplasms; Rats; Rhabdomyosarcoma; Staining and Labeling	1973
Potentially useful combinations of chemotherapy detected in mouse tumor systems. Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes	1974
Haematological effects of chronic ethanol administration and folic acid deficiency in mice. Acta haematologica, 1973, Volume: 49, Issue:4 Topics: Alcoholic Intoxication; Anemia; Animals; Disease Models, Animal; Folic Acid Deficiency; Hematopoiesis; Humans; Male; Methotrexate; Mice	1973
The growth of human tumours in immunosuppressed mice and their response to chemotherapy. British journal of cancer, 1974, Volume: 30, Issue:1 Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunosuppression Therapy; Male; Melphalan; Methotrexate; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Ovarian Neoplasms; Thiotepa; Thymectomy; Transplantation, Heterologous; Triaziquone; Urinary Bladder Neoplasms; Vinblastine; Vincristine	1974
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil. Journal of the National Cancer Institute, 1971, Volume: 46, Issue:2 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Evaluation Studies as Topic; Fluorouracil; Glioma; Injections, Intraperitoneal; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Plicamycin; Urea; Vincristine	1971
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas. Journal of neurosurgery, 1969, Volume: 31, Issue:6 Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; Blood-Brain Barrier; Brain; Brain Neoplasms; Bromodeoxyuridine; Cell Division; Cell Transformation, Neoplastic; Disease Models, Animal; Fluorouracil; Glioblastoma; Humans; Injections, Intra-Arterial; Injections, Spinal; Mechlorethamine; Methotrexate; Nitroso Compounds; Thiotepa; Time Factors; Urea; Vincristine	1969
The effect of methotrexate and dactinomycin on transplantable malignant and benign trophoblastic growths. American journal of obstetrics and gynecology, 1970, Jun-15, Volume: 107, Issue:4 Topics: Animals; Cheek; Choriocarcinoma; Cricetinae; Dactinomycin; Disease Models, Animal; Drug Synergism; Female; Humans; Methotrexate; Neoplasm Transplantation; Neoplasms, Experimental; Pregnancy; Trophoblastic Neoplasms	1970
A re-examination of the renal blastema graft model for Wilms tumor production. The Journal of urology, 1974, Volume: 111, Issue:6 Topics: Animals; Autopsy; Cell Differentiation; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Drug Therapy, Combination; Female; Fetus; Fluorouracil; Kidney; Kidney Neoplasms; Kidney Transplantation; Male; Methotrexate; Mice; Mice, Inbred Strains; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Pregnancy; Testicular Neoplasms; Transplantation, Homologous; Vincristine; Wilms Tumor	1974
ICRF-159 in treatment of germinal testicular tumor in animals. Urology, 1974, Volume: 4, Issue:3 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Dogs; Drug Therapy, Combination; Fluorouracil; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Piperazines; Propane; Teratoma; Testicular Neoplasms; Vincristine	1974
Combination chemotherapy for spontaneous AKR lymphoma. Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytarabine; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Lymphoma; Methotrexate; Mice; Mice, Inbred AKR; Neoplasms, Experimental; Nitrosourea Compounds; Organ Size; Palmitic Acids; Prednisone; Remission, Spontaneous; Rodent Diseases; Spleen; Splenomegaly; Thymus Gland; Time Factors; Vincristine	1974
Attempts at immunotherapy of 100 patients with acute lymphoid leukemia: some factors influencing results. National Cancer Institute monograph, 1972, Volume: 35 Topics: Animals; Bone Marrow Examination; Central Nervous System; Corynebacterium; Cytarabine; Cytotoxicity Tests, Immunologic; Disease Models, Animal; Female; Humans; Immune Sera; Immunotherapy; Leukemia, Experimental; Leukemia, Lymphoid; Lymphocyte Activation; Male; Methotrexate; Mice; Mice, Inbred AKR; Remission, Spontaneous	1972
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse. Cancer research, 1974, Volume: 34, Issue:8 Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, Animal; Drug Therapy, Combination; Ethylenediamines; Fluorenes; Fluorouracil; Interferon Inducers; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Prednisolone; Thioxanthenes; Vincristine	1974
Keynote address on chemotherapy for lung cancer. Cancer chemotherapy reports. Part 3, 1973, Volume: 4, Issue:2 Topics: Alkylating Agents; Carcinoma; Cyclophosphamide; Disease Models, Animal; Humans; Lung Neoplasms; Methotrexate; Nitrosourea Compounds; Research	1973
[Leukemia L 5222 of the rat strain BD IX. An ethylnitrosourea-induced monocytic-myeloic transplantable form for cytochemical and chemotherapeutic studies]. Blut, 1974, Volume: 28, Issue:4 Topics: Alkaline Phosphatase; Animals; Cell Transformation, Neoplastic; Cyclophosphamide; Disease Models, Animal; Esterases; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Leukemia, Experimental; Liver; Lymph Nodes; Mercaptopurine; Methotrexate; Neoplasm Transplantation; Nitrosourea Compounds; Peroxidases; Rats; Rats, Inbred Strains; Spleen; Transplantation, Homologous; Vincristine	1974
The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors. Cancer research, 1972, Volume: 32, Issue:10 Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Bone Marrow; Brain; Brain Neoplasms; Carbon Isotopes; Carmustine; Cyclohexanes; Cytarabine; Deoxyuridine; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Ependymoma; Glioma; Lymph Nodes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Thymidine; Tritium	1972
Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 178, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis; Aspirin; Body Weight; Cyclophosphamide; Disease Models, Animal; Freund's Adjuvant; Hindlimb; Immunosuppressive Agents; Indomethacin; Male; Methotrexate; Muramidase; Phenylbutazone; Prednisolone; Rats	1971
Resistance of Chinese hamsters to Hymenolepis microstoma and its reversal by immunosuppression. The Journal of parasitology, 1971, Volume: 57, Issue:6 Topics: Abdominal Neoplasms; Animals; Bile Ducts; Cestoda; Cricetinae; Disease Models, Animal; Duodenum; Female; Freund's Adjuvant; Granuloma; Hymenolepiasis; Hypertrophy; Immunosuppression Therapy; Injections, Intraperitoneal; Larva; Male; Methotrexate; Mice; Ovum; Pancreas; Time Factors	1971
The treatment of acute lymphocytic leukemia. Journal of chronic diseases, 1970, Volume: 22, Issue:10 Topics: Animals; Antineoplastic Agents; Asparaginase; Blood Platelets; Bone Marrow Cells; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Synergism; Hemorrhage; Humans; Infections; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Mice; Prednisone; Prognosis; Thrombocytopenia; Vincristine	1970
Therapy of acute leukemia. Hamatologie und Bluttransfusion, 1970, Volume: 9 Topics: Adolescent; Animals; Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Daunorubicin; Disease Models, Animal; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mice; Remission, Spontaneous; Vincristine	1970
Suppression of experimental allergic encephalomyelitis by NSC 82196, a new imidazole carboxamide derivative. Cancer research, 1969, Volume: 29, Issue:12 Topics: Amides; Animals; Azathioprine; Cyclophosphamide; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Imidazoles; Immunosuppressive Agents; Methotrexate; Nitrogen Mustard Compounds; Rats	1969
The effect of chemotherapy on germinal testicular tumors in mice. Cancer, 1970, Volume: 26, Issue:3 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; Male; Methotrexate; Mice; Neoplasm Transplantation; Teratoma; Testicular Neoplasms; Time Factors; Vincristine	1970
Studies on the chemotherapy of experimental brain tumors: evaluation of 1,3-bis(2-chloroethyl)-l-nitrosourea, cyclophosphamide, mithramycin, and methotrexate. Cancer research, 1970, Volume: 30, Issue:9 Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymoma; Glioma; Injections; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Statistics as Topic; Urea	1970
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules. Cancer chemotherapy reports, 1970, Volume: 54, Issue:6 Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Half-Life; Hydroxyurea; In Vitro Techniques; Kinetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitrosourea Compounds; Thiosemicarbazones	1970
Effects of hormones, methotrexate, and dactinomycin on benign trophoblast. American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3 Topics: Animals; Chorionic Gonadotropin; Cricetinae; Dactinomycin; Disease Models, Animal; Estradiol; Methotrexate; Placenta; Progesterone; Transplantation, Heterologous; Trophoblasts	1971
Differential effects of anti-tumour drugs on human tumour and spleen DNA synthesis in vitro. Archives internationales de pharmacodynamie et de therapie, 1971, Volume: 190, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Culture Techniques; Disease Models, Animal; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Spleen	1971