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methotrexate and Deficiency, Vitamin B 12

methotrexate has been researched along with Deficiency, Vitamin B 12 in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (74.19)	18.7374
1990's	3 (9.68)	18.2507
2000's	4 (12.90)	29.6817
2010's	1 (3.23)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW	1
Budu, P; Nijhout, HF; Reed, MC; Ulrich, CM	1
Bisbe, E; Castillo, J; García-Erce, JA; Pérez, C; Sáez, M	1
Scott, JM; Weir, DG	1
Bond, AN; Harris, G; Wickramasinghe, SN	1
Sauer, H	1
Das, KC; Garewal, G; Mohanty, D	1
Fernandes-Costa, F; Metz, J; Miller, H	1
Fogari, RA; Hoch, S	1
Arza, B; Barceló, MJ; Cadafalch, J; García-Die, F; Parellada, MM; Remacha, A	1
Abad, LW; Dellaripa, P; Muldoon, BA; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Selhub, J	1
Hoffbrand, AV; Weir, DG	1
Eichholzer, M; Gutzwiller, F; Lüthy, J; Moser, U; Stähelin, HB	1
Van Der Weyden, MB	1
Hoffbrand, AV; Wickremasinghe, RG	1
Marquet, J; Zittoun, J; Zittoun, R	1
Hoffbrand, AV	1
Reynolds, EH	1
Sauer, H; Wilmanns, W	1
Hoffbrand, AV; Hooton, JW	2
Clarkson, DR; Moore, EM	1
Bessman, JD; Johnson, RK	1
Iwata, N; Maekawa, T; Omine, M; Yamauchi, H	1
Gawthorne, JM; Smith, RM	1
Wilmanns, W	1
Weinstein, WM	1
van Roon-Djordjević, B	1
Firkin, B; Rother, M; Van der Weyden, M	1
Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S	1
Herbert, V; Metz, J; Waxman, S	1

Reviews

4 review(s) available for methotrexate and Deficiency, Vitamin B 12

Article	Year
[Safety aspects of folic acid for the general population]. Praxis, 2002, Jan-09, Volume: 91, Issue:1-2 Topics: Adult; Animals; Anticonvulsants; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Child; Cohort Studies; Double-Blind Method; Drug Hypersensitivity; Drug Interactions; Epilepsy; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant, Newborn; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Placebos; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Vitamin B 12 Deficiency; Zinc	2002
Synthesis and breakdown of natural folates (folate polyglutamates). Progress in hematology, 1975, Volume: 9 Topics: Animals; Bacteria; Folic Acid; gamma-Glutamyl Hydrolase; Glutamates; Humans; Intestinal Absorption; Methotrexate; Peptides; Rats; Vitamin B 12 Deficiency	1975
Neurological aspects of folate and vitamin B12 metabolism. Clinics in haematology, 1976, Volume: 5, Issue:3 Topics: Adult; Aged; Anemia, Megaloblastic; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Diseases; Child; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Metabolism, Inborn Errors; Methotrexate; Middle Aged; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1976
Epithelial cell renewal of the small intestinal mucosa. The Medical clinics of North America, 1974, Volume: 58, Issue:6 Topics: Celiac Disease; Cell Differentiation; Cell Division; Cell Movement; Colchicine; Cytological Techniques; Epithelial Cells; Epithelium; Folic Acid Deficiency; Humans; Intestinal Mucosa; Intestine, Small; Malabsorption Syndromes; Methotrexate; Mitosis; Radiation Effects; Thymidine; Time Factors; Tritium; Vitamin B 12 Deficiency	1974

Other Studies

27 other study(ies) available for methotrexate and Deficiency, Vitamin B 12

Article	Year
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5 Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Humans; Leukemia; Methionine; Methotrexate; Myelin Sheath; Neurotoxicity Syndromes; Nitrous Oxide; Nutritional Status; Seizures; Vitamin B 12 Deficiency	2016
A mathematical model of the folate cycle: new insights into folate homeostasis. The Journal of biological chemistry, 2004, Dec-31, Volume: 279, Issue:53 Topics: Allosteric Site; Animals; Dose-Response Relationship, Drug; Folic Acid; Homeostasis; Humans; Kinetics; Liver; Methionine; Methotrexate; Models, Biological; Models, Chemical; Models, Theoretical; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Up-Regulation; Vitamin B 12 Deficiency	2004
[Delayed improvement of anemia treated with intravenous iron and epoetin alfa after hip replacement surgery]. Revista espanola de anestesiologia y reanimacion, 2005, Volume: 52, Issue:8 Topics: Adult; Anemia, Hypochromic; Arthroplasty, Replacement, Hip; Chronic Disease; Colitis; Drug Therapy, Combination; Epoetin Alfa; Erythropoietin; Ferric Compounds; Folic Acid; Humans; Intestinal Polyps; Leucovorin; Malabsorption Syndromes; Male; Methotrexate; Osteoarthritis, Hip; Preoperative Care; Recombinant Proteins; Rectal Diseases; Remission Induction; Spondylitis, Ankylosing; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency	2005
The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet (London, England), 1981, Aug-15, Volume: 2, Issue:8242 Topics: Acute Disease; Anemia, Pernicious; Bone Marrow; Cell Division; Folic Acid; Folic Acid Deficiency; Humans; Kwashiorkor; Methionine; Methotrexate; Models, Biological; Vitamin B 12 Deficiency	1981
DNA chain elongation rates in marrow cells from vitamin B12-deficient patients and methotrexate-treated mice. British journal of haematology, 1982, Volume: 50, Issue:2 Topics: Anemia, Megaloblastic; Animals; Bone Marrow; Chromatography; DNA; Durapatite; Female; Humans; Hydroxyapatites; Hydroxyurea; Lymphocyte Activation; Male; Methotrexate; Mice; Mice, Inbred BALB C; Vitamin B 12 Deficiency	1982
[Vitamin B12 as a regulator and methotrexate as an antagonist of folic acid metabolism. Pathophysiologic and clinical aspects]. Fortschritte der Medizin, 1983, Apr-21, Volume: 101, Issue:15 Topics: DNA; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency	1983
Derangement of DNA synthesis in erythroleukaemia. Normal deoxyuridine suppression and impaired thymidine incorporation in bone marrow culture. Acta haematologica, 1980, Volume: 64, Issue:3 Topics: Adolescent; Adult; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Female; Folic Acid Deficiency; Humans; Leukemia, Erythroblastic, Acute; Male; Methotrexate; Middle Aged; Thymidine; Vitamin B 12 Deficiency	1980
Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus). The British journal of nutrition, 1980, Volume: 44, Issue:3 Topics: Animals; Bone Marrow; Cells, Cultured; Chiroptera; Deoxyuridine; DNA; Folic Acid; Lymphocytes; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1980
Methotrexate for chronic diseases in adults. The New England journal of medicine, 1995, Jun-29, Volume: 332, Issue:26 Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Folic Acid; Humans; Methotrexate; Vitamin B 12 Deficiency	1995
The deoxyuridine suppression test in HIV-1 positive patients: the role of azydothymidine (AZT). European journal of haematology, 1996, Volume: 56, Issue:4 Topics: Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; Folic Acid; HIV Infections; HIV-1; Humans; Intestinal Absorption; Methotrexate; Vitamin B 12; Vitamin B 12 Deficiency; Zidovudine	1996
Abnormal homocysteine metabolism in rheumatoid arthritis. Arthritis and rheumatism, 1997, Volume: 40, Issue:4 Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	1997
The history of folic acid. British journal of haematology, 2001, Volume: 113, Issue:3 Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency	2001
Deoxyuridine metabolism in human megaloblastic marrow cells. Scandinavian journal of haematology, 1979, Volume: 23, Issue:1 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency	1979
Defective DNA synthesis in megaloblastic anaemia. Studies employing velocity sedimentation in alkaline sucrose gradients. Biochimica et biophysica acta, 1979, Jun-20, Volume: 563, Issue:1 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoradiography; Centrifugation, Density Gradient; DNA Replication; Folic Acid Deficiency; Humans; Hydroxyurea; In Vitro Techniques; Lymphocytes; Methotrexate; Vitamin B 12 Deficiency	1979
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency. Blood, 1978, Volume: 51, Issue:1 Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1978
Cobalamin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency. British journal of haematology, 1977, Volume: 36, Issue:2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Folic Acid; Humans; Methotrexate; Methyltransferases; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency	1977
DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs. Biochimica et biophysica acta, 1977, Aug-02, Volume: 477, Issue:3 Topics: Adenosine Triphosphate; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Cell Nucleus; Cytarabine; DNA; DNA Replication; DNA-Directed DNA Polymerase; Ethylmaleimide; Female; Fluorouracil; Folic Acid Deficiency; Humans; Hydroxyurea; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Middle Aged; Thymine Nucleotides; Vitamin B 12 Deficiency	1977
Reticulocyte size in nutritional anemias. Blood, 1976, Volume: 48, Issue:5 Topics: Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Blood Volume Determination; Bloodletting; Folic Acid Deficiency; Hematocrit; Humans; Methotrexate; Rats; Reticulocytes; Vitamin B 12 Deficiency	1976
Thymidine kinase in megaloblastic anaemia. British journal of haematology, 1976, Volume: 33, Issue:4 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Male; Methotrexate; Puromycin; Sonication; Thymidine Kinase; Vitamin B 12; Vitamin B 12 Deficiency	1976
Erythrocyte volume distribution in normal and abnormal subjects. Blood, 1975, Volume: 46, Issue:3 Topics: Adenocarcinoma; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Brain Diseases; Electronics, Medical; Erythrocyte Count; Erythrocytes; Female; Folic Acid Deficiency; Heart Failure; Hematocrit; Hemorrhage; Humans; Male; Methotrexate; Middle Aged; Reticulocytes; Thrombophlebitis; Vitamin B 12 Deficiency; Warfarin	1975
[Folate status in vitamin B12-deficient megaloblastic bone marrow cells: enhanced sensitivity to methotrexate and increased rescue effects of folates]. Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1988, Volume: 51, Issue:3 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Deoxyuridine; DNA; Female; Folic Acid; Humans; Male; Methotrexate; Vitamin B 12 Deficiency	1988
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver. The Biochemical journal, 1974, Volume: 142, Issue:1 Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency	1974
[Folate enzymes and thymidilate synthesis in erythrocytes and bone marrow cells under normal and pathologic conditions]. Folia haematologica (Leipzig, Germany : 1928), 1968, Volume: 89, Issue:2 Topics: Bone Marrow; Bone Marrow Cells; DNA; Erythrocytes; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemoglobinuria, Paroxysmal; Histidine; Humans; Liver Cirrhosis; Methotrexate; Nucleotides; RNA; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Vitamin B 12 Deficiency	1968
Urinary excretion of histidine metabolites as an indication for folic acid and vitamin B 12 deficiency. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 41 Topics: Adolescent; Adult; Aged; Chromatography, Ion Exchange; Chromatography, Thin Layer; Contraceptives, Oral; Electrophoresis; Female; FIGLU Test; Folic Acid Deficiency; Histidine; Humans; Hydantoins; Imidazoles; Male; Methods; Methotrexate; Middle Aged; Propionates; Vitamin B 12 Deficiency	1972
Megaloblastic maturation masked by iron deficiency: a biochemical basis. British journal of haematology, 1972, Volume: 22, Issue:3 Topics: Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Culture Techniques; Deferoxamine; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Iron; Methotrexate; Thymidine; Tritium; Vitamin B 12 Deficiency	1972
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans. British journal of haematology, 1968, Volume: 14, Issue:6 Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency	1968
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine. The Journal of clinical investigation, 1969, Volume: 48, Issue:2 Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency	1969