Page last updated: 2024-08-25

methotrexate and Deficiency, Folic Acid

methotrexate has been researched along with Deficiency, Folic Acid in 92 studies

Research

Studies (92)

Timeframe	Studies, this research(%)	All Research%
pre-1990	59 (64.13)	18.7374
1990's	12 (13.04)	18.2507
2000's	9 (9.78)	29.6817
2010's	11 (11.96)	24.3611
2020's	1 (1.09)	2.80

Authors

Authors	Studies
Aluri, S; Fiser, A; Goldman, ID; Lin, K; Najmi, M; Zhan, HQ; Zhao, R	1
Al-Dabagh, A; Davis, SA; Feldman, SR; Huang, K; Kinney, MA	1
Guan, T; Guan, Z; Li, G; Niu, B; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhu, Z	1
Arora, J; Blair, IA; Hammons, AL; Jochems, J; Summers, CM; Whitehead, AS; Zhang, S	1
Abbass, K; Gertner, E; Haveman, L	1
Kumar, A; Moulik, NR	1
Chen, Y; Dong, Y; Guan, Z; Niu, B; Niu, Y; Wang, J; Wang, X; Zhang, T	1
van Erp-van der Steen, H; van Kouwen, MC	1
Furukawa, S; Hirako, A; Sugiyama, A; Takeuchi, T	1
Cao, H; Huang, Z; Jiang, Q; Jiang, Z; Li, C; Li, J; Niu, B; Qiu, Z; Song, X; Wan, C; Wu, L; Xie, Q; Yang, F; Yu, K; Zhang, T	1
Ayric, Z; Blau, N; Blom, H; Bode, H; Cario, H; Debatin, KM; Holzmann, K; Hopfner, KP; Kohne, E; Pannicke, U; Rump, EM; Schwarz, K; Smith, DE; Smulders, Y	1
Guan, T; Guan, Z; Niu, B; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhao, J	1
Christensen, PB; Ekelund, S; Hansen, H; Jensen, OK; Mollerup, F; Rasmussen, C; Thulstrup, AM	1
González-Quevedo, A; Lima, L; Obregón, F; Roussó, T; Urbina, M	1
BIGNOTTI, G; TOGNELLA, S	1
COOPER, BA; LOWENSTEIN, L	1
MALANDRINI, F; PIERI, I; VEDOVINI, F	1
BRIGGS, GM; POTTER, M	1
Al-Khan, A; Apuzzio, J; Fricchione, D; Jones, R	1
Cronstein, BN	1
Durán Merás, I; Jiménez Girón, A; Muñoz de la Peña, A	1
Chalmers, RJ; Harries, M; Hughes, R; Kirby, B	1
Akabas, MH; Cabelof, DC; Goldman, ID; Jansen, M; Malhotra, U; Matherly, LH; Min, SH; Qiu, A; Tsai, E; Zhao, R	1
Scott, JM; Weir, DG	1
Bertino, JR; Camitta, BM; Kamen, BA; Nylen, PA	1
Barbi, G; Steinbach, P; Vogel, W	1
Fujimoto, K	1
Adams, SM; Fish, BL; Holcenberg, JS; Kamen, BA; Kun, LE; Moulder, JE; Ring, BJ	1
DePaola, DP; Mandella, RD	2
Holcenberg, JS; Kamen, BA; Turo, K; Whitehead, VM	1
Sauer, H	1
Das, KC; Garewal, G; Mohanty, D	1
Blair, JA; Lucas, ML; Swanston-Flatt, SK	1
Ames, BN; Blount, BC	1
Crowe, SF; Ross, CK	1
Andersen, LS; Hansen, EL; Hansen, GV; Hansen, TM; Knudsen, JB; Wester, JU	1
Shiroky, JB	1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL	1
Endresen, GK; Husby, G	2
Baggott, JE; Johanning, GL	1
Hoffbrand, AV; Weir, DG	1
Makar, AB; Tephly, TR	1
Bonhomme, JS; Bureau, JP; Ritter, J	2
Van Der Weyden, MB	1
Hoffbrand, AV; Wickremasinghe, RG	1
Hoffbrand, AV	1
Celada, A; Donath, A; Rudolf, H	1
Marquet, J; Zittoun, J; Zittoun, R	1
Warkany, J	1
Reynolds, EH	1
Hoffbrand, AV; Hooton, JW	2
Clarkson, DR; Moore, EM	1
Garwicz, S; Mortensson, W	1
Hayashi, K	1
Bessman, JD; Johnson, RK	1
Ema, H; Iwama, A; Miura, Y; Miwa, A; Sakamoto, S; Suda, T; Suzuki, T	1
Procter, A	1
Bottiglieri, T; Carney, MW; Chanarin, I; Flynn, TG; Godfrey, PS; Laundy, M; Reynolds, EH; Toone, BK	1
Andersson, BS; Dreizen, S; Keating, MJ; McCredie, KB	1
Galivan, J; Kamen, B; Kremer, JM; Streckfuss, A	1
Helland, S; Refsum, H; Ueland, PM	1
Davis, RE	1
Al-Ansari, HM; Farkas, WR; Walden, TL	1
Cohen, P; Dix, D	1
Sourial, NA	1
Lutsiuk, MB	1
Wilmanns, W	1
Ericson, U; Lockner, D	1
Honig, GR; Mason, RG; Vida, LN	1
Robenberg, IH	1
de Waard, H	1
Hoffbrand, AV; Tripp, E	1
Newbold, PC	1
Weinstein, WM	1
van Roon-Djordjević, B	1
Ganeshaguru, K; Hoffbrand, AV; Lavoie, A; Tattersall, MH; Tripp, E	1
Weir, DG	1
Dreizen, S; Levy, BM	1
Firkin, B; Rother, M; Van der Weyden, M	1
Ellegaard, J; Esmann, V; Henriksen, L	1
Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S	1
Yoshino, T	1
Bartosik, DB; Romanoff, EB; Willmott, M	1
Herbert, V; Metz, J; Waxman, S	1
Malorny, G; Rietbrock, N; Stieren, B	1

Reviews

8 review(s) available for methotrexate and Deficiency, Folic Acid

Article	Year
The effect of folate supplementation on methotrexate efficacy and toxicity in psoriasis patients and folic acid use by dermatologists in the USA. American journal of clinical dermatology, 2013, Volume: 14, Issue:3 Topics: Dermatology; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Methotrexate; Psoriasis; United States	2013
The use of folates concomitantly with low-dose pulse methotrexate. Rheumatic diseases clinics of North America, 1997, Volume: 23, Issue:4 Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate	1997
[Methotrexate and folates in rheumatoid arthritis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1999, Feb-10, Volume: 119, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Randomized Controlled Trials as Topic	1999
Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines. Scandinavian journal of rheumatology, 2001, Volume: 30, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Practice Guidelines as Topic	2001
Neurological aspects of folate and vitamin B12 metabolism. Clinics in haematology, 1976, Volume: 5, Issue:3 Topics: Adult; Aged; Anemia, Megaloblastic; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Diseases; Child; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Metabolism, Inborn Errors; Methotrexate; Middle Aged; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1976
Megaloblastic anemia associated with psoriasis: case report and review of the literature. Internal medicine (Tokyo, Japan), 1992, Volume: 31, Issue:1 Topics: Aged; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Male; Methotrexate; Psoriasis	1992
Clinical chemistry of folic acid. Advances in clinical chemistry, 1986, Volume: 25 Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim	1986
Epithelial cell renewal of the small intestinal mucosa. The Medical clinics of North America, 1974, Volume: 58, Issue:6 Topics: Celiac Disease; Cell Differentiation; Cell Division; Cell Movement; Colchicine; Cytological Techniques; Epithelial Cells; Epithelium; Folic Acid Deficiency; Humans; Intestinal Mucosa; Intestine, Small; Malabsorption Syndromes; Methotrexate; Mitosis; Radiation Effects; Thymidine; Time Factors; Tritium; Vitamin B 12 Deficiency	1974

Trials

4 trial(s) available for methotrexate and Deficiency, Folic Acid

Article	Year
Prospectively measured red cell folate levels in methotrexate treated patients with rheumatoid arthritis: relation to withdrawal and side effects. The Journal of rheumatology, 1997, Volume: 24, Issue:5 Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Lactoglobulins; Male; Methotrexate; Middle Aged; Prospective Studies; Radioligand Assay; Substance Withdrawal Syndrome	1997
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention. The Journal of rheumatology, 1998, Volume: 25, Issue:3 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged	1998
Enhancement of recovery from psychiatric illness by methylfolate. The British journal of psychiatry : the journal of mental science, 1991, Volume: 159 Topics: Depressive Disorder; Double-Blind Method; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Schizophrenia; Schizophrenic Psychology	1991
Enhancement of recovery from psychiatric illness by methylfolate. Lancet (London, England), 1990, Aug-18, Volume: 336, Issue:8712 Topics: Adult; Aged; Depressive Disorder; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Schizophrenia; Vitamin B 12	1990

Other Studies

80 other study(ies) available for methotrexate and Deficiency, Folic Acid

Article	Year
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. The Journal of biological chemistry, 2020, 11-13, Volume: 295, Issue:46 Topics: Amino Acid Sequence; Animals; Biological Transport; Cysteine; Folic Acid Deficiency; HeLa Cells; Humans; Kinetics; Malabsorption Syndromes; Methotrexate; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Proton-Coupled Folate Transporter	2020
Role of methotrexate exposure in apoptosis and proliferation during early neurulation. Journal of applied toxicology : JAT, 2014, Volume: 34, Issue:8 Topics: Animals; Apoptosis; Caspase 3; Cell Proliferation; Disease Models, Animal; Down-Regulation; Embryonic Development; Epithelial Cells; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Histones; Methotrexate; Mice; Mice, Inbred C57BL; Microarray Analysis; Neural Tube Defects; Neurulation; Pregnancy; Tetrahydrofolate Dehydrogenase; Up-Regulation	2014
Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. European journal of pharmacology, 2014, Jun-05, Volume: 732 Topics: Antimetabolites, Antineoplastic; Atherosclerosis; Bromodeoxyuridine; Cell Line; Cell Proliferation; Cell Survival; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Gene Expression; Humans; Inflammation; Methotrexate; Phenotype	2014
Esophagitis dissecans superficialis due to severe methotrexate toxicity. Endoscopy, 2014, Volume: 46 Suppl 1 UCTN Topics: Arthritis; Esophagitis; Esophagoscopy; Female; Folic Acid Deficiency; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Oral Ulcer; Skin Ulcer	2014
Are concerns about folic acid supplementation in children with acute lymphoblastic leukemia justified? Indian pediatrics, 2014, Volume: 51, Issue:9 Topics: Antineoplastic Agents; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2014
Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism. PloS one, 2015, Volume: 10, Issue:3 Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; DNA Methylation; Embryonic Development; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Protein Serine-Threonine Kinases; Tandem Mass Spectrometry; Ubiquitin-Protein Ligases; Wnt Signaling Pathway	2015
[A man with multiple mucosal lesions and pancytopenia]. Nederlands tijdschrift voor geneeskunde, 2015, Volume: 159 Topics: Diagnosis, Differential; Folic Acid Deficiency; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Psoriasis	2015
Effect of methotrexate exposure at late gestation on development of telencephalon in rat fetal brain. The Journal of veterinary medical science, 2016, Volume: 78, Issue:2 Topics: Abortifacient Agents, Nonsteroidal; Animals; Embryonic Development; Female; Folic Acid Deficiency; Gestational Age; Methotrexate; Pregnancy; Rats; Rats, Wistar; Telencephalon	2016
Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription. Nucleic acids research, 2017, 03-17, Volume: 45, Issue:5 Topics: Animals; Cells, Cultured; DNA Breaks, Double-Stranded; Embryonic Stem Cells; Fetus; Folic Acid Antagonists; Folic Acid Deficiency; G1 Phase; Gene Expression Regulation, Developmental; Genes, rRNA; Histones; Leucovorin; Methotrexate; Mice; Neural Tube Defects; Pol1 Transcription Initiation Complex Proteins; Transcription, Genetic	2017
Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. American journal of human genetics, 2011, Feb-11, Volume: 88, Issue:2 Topics: Anemia, Megaloblastic; Child; Child, Preschool; Erythrocytes; Female; Fluoresceins; Folic Acid; Folic Acid Deficiency; Homozygote; Humans; Male; Methotrexate; Models, Molecular; Mutation; Nervous System Diseases; Pedigree; Protein Conformation; Tetrahydrofolate Dehydrogenase	2011
Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability. Journal of applied toxicology : JAT, 2013, Volume: 33, Issue:9 Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Diet; DNA Copy Number Variations; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Genomic Instability; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neural Tube; Neural Tube Defects; Pregnancy; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase	2013
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation. The Journal of rheumatology, 2002, Volume: 29, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome	2002
Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience, 2003, Volume: 6, Issue:4 Topics: Amino Acids; Animals; Asparagine; beta-Alanine; Biogenic Monoamines; Brain; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Drinking; Folic Acid Deficiency; Hippocampus; Hydroxyindoleacetic Acid; Male; Methanol; Methotrexate; Optic Nerve; Rats; Rats, Sprague-Dawley; Retina; Serotonin; Taurine; Threonine	2003
[LABORATORY TESTS FOR VERIFYING STATES OF FOLIC ACID DEFICIENCY IN THE ORGANISM]. Recenti progressi in medicina, 1964, Volume: 36 Topics: Aminopterin; Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood; Clinical Laboratory Techniques; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Lactobacillus; Leuconostoc; Liver Diseases; Methotrexate; Neoplasms; Nutrition Disorders; Pregnancy; Staphylococcus; Urine; Vitamin B Deficiency	1964
RELATIVE FOLATE DEFICIENCY OF ERYTHROCYTES IN PERNICIOUS ANEMIA AND ITS CORRECTION WITH CYANOCOBALAMIN. Blood, 1964, Volume: 24 Topics: Anemia; Anemia, Hypochromic; Anemia, Pernicious; Biological Assay; Blood Chemical Analysis; Chromatography; Erythrocytes; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Lactobacillus; Metabolism; Methotrexate; Vitamin B 12	1964
[EFFECT OF 6-MERCAPTOPURINE, OF AMINOMETHYLPTEROYLGLUTAMIC ACID AND OF FOLIC ACID DEFICIENCY ON ANTI-INFLUENZAL ANTIBODY PRODUCTION IN THE MOUSE]. Atti della Accademia dei fisiocritici in Siena. Sezione medico-fisica, 1963, Volume: 12 Topics: Animals; Antibody Formation; Folic Acid; Folic Acid Deficiency; Humans; Influenza, Human; Mercaptopurine; Methotrexate; Mice; Research	1963
Inhibition of growth of amethopterinsensitive and amethopterin-resistant pairs of lymphocytic neoplasms by dietary folic-acid deficiency in mice. Journal of the National Cancer Institute, 1962, Volume: 28 Topics: Animals; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental	1962
Intravenous methotrexate for treatment of interstitial pregnancy: a case report. The Journal of reproductive medicine, 2004, Volume: 49, Issue:2 Topics: Abortifacient Agents, Nonsteroidal; Adult; Chorionic Gonadotropin, beta Subunit, Human; Female; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Infusions, Intravenous; Methotrexate; Pregnancy; Pregnancy, Ectopic; Time Factors; Treatment Outcome	2004
Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al. Arthritis and rheumatism, 2005, Volume: 52, Issue:4 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Drug Antagonism; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Purines	2005
Four-way calibration applied to the simultaneous determination of folic acid and methotrexate in urine samples. Analytical and bioanalytical chemistry, 2006, Volume: 385, Issue:7 Topics: Calibration; Folic Acid; Folic Acid Deficiency; Humans; Kinetics; Methotrexate; Spectrum Analysis; Urine	2006
Folic acid supplementation and methotrexate therapy for psoriasis. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:2 Topics: Dermatologic Agents; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methotrexate; Psoriasis	2006
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:5 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Cell Membrane; Disease Models, Animal; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; HeLa Cells; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Male; Membrane Potentials; Membrane Transport Proteins; Methotrexate; Mice; Mice, Inbred C57BL; Microvilli; Molecular Sequence Data; Oocytes; Polyglutamic Acid; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Proton-Coupled Folate Transporter; Rats; RNA, Messenger; Tetrahydrofolates; Xenopus	2007
The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet (London, England), 1981, Aug-15, Volume: 2, Issue:8242 Topics: Acute Disease; Anemia, Pernicious; Bone Marrow; Cell Division; Folic Acid; Folic Acid Deficiency; Humans; Kwashiorkor; Methionine; Methotrexate; Models, Biological; Vitamin B 12 Deficiency	1981
Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug. British journal of haematology, 1981, Volume: 49, Issue:3 Topics: Erythrocytes; Folic Acid; Folic Acid Deficiency; Leukemia, Lymphoid; Liver; Methotrexate; Polyglutamic Acid	1981
Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites. Human genetics, 1984, Volume: 68, Issue:4 Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Folic Acid Deficiency; Humans; Karyotyping; Lymphocytes; Methotrexate	1984
Periodontal tissue changes in a recovery experiment using folic acid-deficient rats. Journal of Osaka Dental University, 1984, Volume: 18, Issue:1 Topics: Animals; Folic Acid Deficiency; Gingiva; Leucovorin; Male; Methotrexate; Periodontium; Rats; Rats, Inbred Strains	1984
Effects of single-dose and fractionated cranial irradiation on rat brain accumulation of methotrexate. Cancer research, 1984, Volume: 44, Issue:11 Topics: Animals; Brain; Folic Acid Deficiency; Male; Methotrexate; Rats; Rats, Inbred Strains; Time Factors	1984
Folate deficiency and in vitro palatogenesis II: Effects of methotrexate on rabbit palate fusion, folate pools, and dihydrofolate reductase activity. Journal of craniofacial genetics and developmental biology, 1984, Volume: 4, Issue:4 Topics: Animals; Female; Fetus; Folic Acid; Folic Acid Deficiency; Gestational Age; In Vitro Techniques; Methotrexate; Palate; Pregnancy; Rabbits; Tetrahydrofolate Dehydrogenase	1984
Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate. The Journal of pediatrics, 1984, Volume: 104, Issue:1 Topics: Administration, Oral; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intramuscular; Leukemia, Lymphoid; Methotrexate; Patient Compliance	1984
[Vitamin B12 as a regulator and methotrexate as an antagonist of folic acid metabolism. Pathophysiologic and clinical aspects]. Fortschritte der Medizin, 1983, Apr-21, Volume: 101, Issue:15 Topics: DNA; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency	1983
Derangement of DNA synthesis in erythroleukaemia. Normal deoxyuridine suppression and impaired thymidine incorporation in bone marrow culture. Acta haematologica, 1980, Volume: 64, Issue:3 Topics: Adolescent; Adult; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Female; Folic Acid Deficiency; Humans; Leukemia, Erythroblastic, Acute; Male; Methotrexate; Middle Aged; Thymidine; Vitamin B 12 Deficiency	1980
Intestinal folic acid absorption and the acid microclimate. The effects of compounds relevant to folate malabsorption. Pflugers Archiv : European journal of physiology, 1981, Volume: 392, Issue:1 Topics: Animals; Ethanol; Folic Acid; Folic Acid Deficiency; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption; Jejunum; Leucine; Malabsorption Syndromes; Methotrexate; Phenytoin; Rats	1981
Folate deficiency and in vitro palatogenesis I: effects of a folate-deficient culture on rabbit palate fusion and folate pools. Journal of craniofacial genetics and developmental biology, 1981, Volume: 1, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; DNA; Female; Folic Acid; Folic Acid Deficiency; In Vitro Techniques; Methotrexate; Palate; Pregnancy; Rabbits	1981
Development of a sensitive assay for detection of uracil in DNA. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; DNA; Folic Acid; Folic Acid Deficiency; Indicators and Reagents; Liver; Mass Spectrometry; Methotrexate; Microchemistry; Rats; Rats, Inbred F344; Uracil	1993
Effect of folate deficiency and folate and B12 excess on memory functioning in young chicks. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Animals; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Memory; Methionine; Methotrexate; Reflex; Time Factors; Vitamin B 12	1997
10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. The Journal of nutrition, 1999, Volume: 129, Issue:7 Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1999
The history of folic acid. British journal of haematology, 2001, Volume: 113, Issue:3 Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency	2001
Methanol poisoning VI: role of folic acid in the production of methanol poisoning in the rat. Journal of toxicology and environmental health, 1977, Volume: 2, Issue:5 Topics: Animals; Folic Acid; Folic Acid Deficiency; Formaldehyde; Formates; Hydrogen-Ion Concentration; Male; Methanol; Methotrexate; Oxidation-Reduction; Rats; Time Factors	1977
[Effects of methotrexate on cervico-vaginal cytology]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1975, Volume: 4, Issue:4 Topics: Adolescent; Adult; Cervix Uteri; Female; Folic Acid Deficiency; Humans; Methotrexate; Pregnancy; Trophoblastic Neoplasms; Vagina; Vaginal Smears	1975
Deoxyuridine metabolism in human megaloblastic marrow cells. Scandinavian journal of haematology, 1979, Volume: 23, Issue:1 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency	1979
Defective DNA synthesis in megaloblastic anaemia. Studies employing velocity sedimentation in alkaline sucrose gradients. Biochimica et biophysica acta, 1979, Jun-20, Volume: 563, Issue:1 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoradiography; Centrifugation, Density Gradient; DNA Replication; Folic Acid Deficiency; Humans; Hydroxyurea; In Vitro Techniques; Lymphocytes; Methotrexate; Vitamin B 12 Deficiency	1979
Pathology of folate deficiency. Proceedings of the Royal Society of Medicine, 1977, Volume: 70, Issue:2 Topics: Anemia, Megaloblastic; Female; Folic Acid Deficiency; Humans; Infertility; Male; Methotrexate; Pigmentation Disorders; Pregnancy; Pregnancy Complications; Pyrimethamine	1977
Effect of experimental chronic alcohol ingestion and folic acid deficiency on iron absorption. Blood, 1979, Volume: 54, Issue:4 Topics: Absorption; Acute Disease; Alcohol Drinking; Alcoholism; Animals; Feces; Folic Acid Deficiency; Humans; Iron; Iron Radioisotopes; Male; Methotrexate; Rabbits	1979
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency. Blood, 1978, Volume: 51, Issue:1 Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1978
Aminopterin and methotrexate: folic acid deficiency. Teratology, 1978, Volume: 17, Issue:3 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortifacient Agents; Aminopterin; Female; Folic Acid Deficiency; Gestational Age; Humans; Methotrexate; Pregnancy	1978
DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs. Biochimica et biophysica acta, 1977, Aug-02, Volume: 477, Issue:3 Topics: Adenosine Triphosphate; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Cell Nucleus; Cytarabine; DNA; DNA Replication; DNA-Directed DNA Polymerase; Ethylmaleimide; Female; Fluorouracil; Folic Acid Deficiency; Humans; Hydroxyurea; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Middle Aged; Thymine Nucleotides; Vitamin B 12 Deficiency	1977
Reticulocyte size in nutritional anemias. Blood, 1976, Volume: 48, Issue:5 Topics: Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Megaloblastic; Animals; Blood Volume Determination; Bloodletting; Folic Acid Deficiency; Hematocrit; Humans; Methotrexate; Rats; Reticulocytes; Vitamin B 12 Deficiency	1976
Thymidine kinase in megaloblastic anaemia. British journal of haematology, 1976, Volume: 33, Issue:4 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Male; Methotrexate; Puromycin; Sonication; Thymidine Kinase; Vitamin B 12; Vitamin B 12 Deficiency	1976
Intracranial calcification mimicking the Sturge-Weber syndrome: a consequence of cerebral folic acid deficiency? Pediatric radiology, 1976, Oct-26, Volume: 5, Issue:1 Topics: Angiomatosis; Brain Diseases; Calcinosis; Child, Preschool; Diagnosis, Differential; Folic Acid Deficiency; Humans; Leukemia; Male; Methotrexate; Radiography; Sturge-Weber Syndrome	1976
A study of oral mucosa changes in folic acid deficient rats. Journal of Osaka Dental University, 1976, Volume: 10, Issue:1-2 Topics: Animals; Epithelium; Folic Acid Antagonists; Folic Acid Deficiency; Methotrexate; Mouth Mucosa; Rats	1976
Erythrocyte volume distribution in normal and abnormal subjects. Blood, 1975, Volume: 46, Issue:3 Topics: Adenocarcinoma; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Brain Diseases; Electronics, Medical; Erythrocyte Count; Erythrocytes; Female; Folic Acid Deficiency; Heart Failure; Hematocrit; Hemorrhage; Humans; Male; Methotrexate; Middle Aged; Reticulocytes; Thrombophlebitis; Vitamin B 12 Deficiency; Warfarin	1975
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 51-1991. A 68-year-old man with recurrent fever and diarrhea after treatment for lymphoma. The New England journal of medicine, 1991, Dec-19, Volume: 325, Issue:25 Topics: Aged; Anemia, Megaloblastic; Bone Marrow; Folic Acid Deficiency; Hematopoietic Stem Cells; Humans; Male; Methotrexate; Psoriasis	1991
Nutritional deficiencies in patients receiving cancer chemotherapy. Postgraduate medicine, 1990, Volume: 87, Issue:1 Topics: Antineoplastic Agents; Cachexia; Folic Acid Deficiency; Humans; Hypoproteinemia; Methotrexate; Neoplasms; Niacin; Nutrition Disorders; Nutritional Status; Pellagra; Riboflavin Deficiency; Thymine; Vitamin B Deficiency; Vitamin K Deficiency	1990
Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates. Arthritis and rheumatism, 1986, Volume: 29, Issue:7 Topics: Arthritis, Rheumatoid; Biopsy; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Liver; Methotrexate; Osmolar Concentration; Peptide Biosynthesis; Polyglutamic Acid	1986
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Psoriasis; Regression Analysis	1989
Methotrexate therapy for psoriasis. JAMA, 1988, Nov-25, Volume: 260, Issue:20 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Female; Folic Acid Deficiency; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Psoriasis	1988
Elevation of blood levels of zinc protoporphyrin by radiomimetic drugs and Friend leukemia virus. Acta oncologica (Stockholm, Sweden), 1987, Volume: 26, Issue:3 Topics: Animals; Antineoplastic Agents; Bone Marrow Transplantation; Cyclophosphamide; Cytarabine; Erythropoiesis; Folic Acid Deficiency; Friend murine leukemia virus; Hydroxyurea; Leukemia, Experimental; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Porphyrins; Protoporphyrins; Radiation Dosage; Radiation Effects; Whole-Body Irradiation	1987
On the role of folate deficiency in cancer therapy. Clinical chemistry, 1988, Volume: 34, Issue:9 Topics: Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Neoplasms	1988
Megaloblastic anaemia and methotrexate treatment. The British journal of dermatology, 1986, Volume: 114, Issue:2 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Folic Acid Deficiency; Humans; Methotrexate; Middle Aged; Psoriasis	1986
Re: Effect of nitrous oxide on human bone marrow cells and its synergistic effect with methionine and methotrexate on functional folate deficiency. Cancer research, 1985, Volume: 45, Issue:12 Pt 1 Topics: Bone Marrow; Cells, Cultured; Drug Synergism; Folic Acid Deficiency; Humans; Methionine; Methotrexate; Nitrous Oxide	1985
[Effect of folic acid, methotrexate and thymine on antibody synthesis]. Ukrains'kyi biokhimichnyi zhurnal, 1970, Volume: 42, Issue:1 Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Erythrocytes; Folic Acid; Folic Acid Deficiency; gamma-Globulins; Hemolysin Proteins; Methotrexate; Mice; Rats; Thymine	1970
[Folate enzymes and thymidilate synthesis in erythrocytes and bone marrow cells under normal and pathologic conditions]. Folia haematologica (Leipzig, Germany : 1928), 1968, Volume: 89, Issue:2 Topics: Bone Marrow; Bone Marrow Cells; DNA; Erythrocytes; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Hemoglobinuria, Paroxysmal; Histidine; Humans; Liver Cirrhosis; Methotrexate; Nucleotides; RNA; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Vitamin B 12 Deficiency	1968
Haematological effects of chronic ethanol administration and folic acid deficiency in mice. Acta haematologica, 1973, Volume: 49, Issue:4 Topics: Alcoholic Intoxication; Anemia; Animals; Disease Models, Animal; Folic Acid Deficiency; Hematopoiesis; Humans; Male; Methotrexate; Mice	1973
Globin chain synthesis in sickle cell trait under conditions of folate antagonism. Acta haematologica, 1974, Volume: 51, Issue:4 Topics: Adolescent; Allopurinol; Anemia, Sickle Cell; Bone Marrow Examination; Carbon Radioisotopes; Electrophoresis, Disc; Electrophoresis, Starch Gel; Erythrocytes; Female; FIGLU Test; Folic Acid Deficiency; Hemoglobins; Hemoglobins, Abnormal; Humans; Leucine; Leukemia, Lymphoid; Methotrexate; Prednisone; Vincristine	1974
[Colpocytogram abnormalities during anemia due to folic acid deficiency]. La Nouvelle presse medicale, 1973, Jun-16, Volume: 2, Issue:24 Topics: Anemia, Macrocytic; Anemia, Sideroblastic; Blood Cell Count; Cell Nucleus; Female; Folic Acid Deficiency; Hematocrit; Humans; Methotrexate; Pregnancy; Pregnancy Complications; Trophoblastic Neoplasms; Vaginal Smears	1973
Drugs and folic acid absorption. Gastroenterology, 1972, Volume: 63, Issue:2 Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexate; Phenytoin; Pyrimethamine; Sulfasalazine; Trimethoprim	1972
[Effect of thymine and adenine in nutrition on folic-acid deficient rats]. Zeitschrift fur Ernahrungswissenschaft, 1974, Volume: 13, Issue:3 Topics: Adenine; Animals; Female; Folic Acid Deficiency; Male; Methotrexate; Rats; Thymine	1974
Unbalanced deoxyribonucleotide synthesis caused by methotrexate. British medical journal, 1972, Apr-15, Volume: 2, Issue:5806 Topics: Adenosine Triphosphate; Chromosome Aberrations; Chromosome Disorders; Deoxyadenosines; Deoxyribonucleotides; DNA; Erythrocytes; Folic Acid Deficiency; Humans; Ligases; Lymphocyte Activation; Lymphocytes; Methotrexate; Polynucleotides; Ribonucleotides; Thymine Nucleotides	1972
Distribution of methotrexate in rat tissues. The British journal of dermatology, 1974, Volume: 90, Issue:6 Topics: Animals; Brain; Carbon Radioisotopes; Folic Acid; Folic Acid Deficiency; Injections, Intraperitoneal; Intestinal Mucosa; Kidney; Leucovorin; Liver; Methotrexate; Rats; Skin; Tritium	1974
Urinary excretion of histidine metabolites as an indication for folic acid and vitamin B 12 deficiency. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 41 Topics: Adolescent; Adult; Aged; Chromatography, Ion Exchange; Chromatography, Thin Layer; Contraceptives, Oral; Electrophoresis; Female; FIGLU Test; Folic Acid Deficiency; Histidine; Humans; Hydantoins; Imidazoles; Male; Methods; Methotrexate; Middle Aged; Propionates; Vitamin B 12 Deficiency	1972
Effect of drugs which cause megaloblastosis on the free intracellular pools of DNA precursors. Clinical science, 1973, Volume: 44, Issue:4 Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyribonucleosides; DNA; Folic Acid Deficiency; Humans; Lymphocytes; Methotrexate; Thymine Nucleotides	1973
The pathogenesis of folic acid deficiency in man. Irish journal of medical science, 1974, Volume: 143, Issue:1 Topics: Adolescent; Adult; Aged; Alcoholism; Anemia, Macrocytic; Animals; Anticonvulsants; Celiac Disease; Child; Diet; Female; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Inflammation; Liver; Male; Metabolic Diseases; Methotrexate; Neoplasms; Pregnancy	1974
Histopathology of experimentally induced nutritional deficiency cheilosis in the marmoset (Callithrix jacchus). Archives of oral biology, 1969, Volume: 14, Issue:6 Topics: Animals; Candidiasis, Oral; Cheilitis; Female; Folic Acid Deficiency; Haplorhini; Leukocytes; Lip; Male; Methotrexate; Mouth Mucosa	1969
Megaloblastic maturation masked by iron deficiency: a biochemical basis. British journal of haematology, 1972, Volume: 22, Issue:3 Topics: Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Culture Techniques; Deferoxamine; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Iron; Methotrexate; Thymidine; Tritium; Vitamin B 12 Deficiency	1972
Deficient folate activity during treatment of psoriasis with methotrexate diagnosed by determination of serine synthesis in lymphocytes. The British journal of dermatology, 1972, Volume: 87, Issue:3 Topics: Adult; Aged; Carbon Isotopes; Female; Folic Acid Deficiency; Formates; Humans; In Vitro Techniques; Intestinal Absorption; Lymphocytes; Male; Methotrexate; Middle Aged; Psoriasis; RNA; Serine; Vitamin B 12	1972
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans. British journal of haematology, 1968, Volume: 14, Issue:6 Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency	1968
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. II. The experimental studies on the absorption site and mechanism of tritiated folic acid in rats. The Journal of vitaminology, 1968, Mar-10, Volume: 14, Issue:1 Topics: Animals; Body Weight; Digestive System; Dinitrophenols; Folic Acid; Folic Acid Deficiency; Gastric Mucosa; Ileum; Jejunum; Kidney; Liver; Male; Methotrexate; Radiometry; Rats; Tritium	1968
The effect of folic acid on superovulation in the immature rat. The Journal of endocrinology, 1968, Volume: 41, Issue:3 Topics: Age Factors; Animals; Chorionic Gonadotropin; Depression, Chemical; Estrone; Female; Folic Acid; Folic Acid Deficiency; Gonadotropins, Equine; Hypophysectomy; Methotrexate; Organ Size; Ovary; Ovulation; Rats; Uterus	1968
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine. The Journal of clinical investigation, 1969, Volume: 48, Issue:2 Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency	1969
[Effect of folic acid on methanol metabolism]. Klinische Wochenschrift, 1966, Nov-15, Volume: 44, Issue:22 Topics: Animals; Dogs; Folic Acid; Folic Acid Deficiency; Formates; Injections, Intravenous; Methanol; Methotrexate	1966