methotrexate has been researched along with Colonic Neoplasms in 255 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 141 (55.29) | 18.7374 |
| 1990's | 58 (22.75) | 18.2507 |
| 2000's | 20 (7.84) | 29.6817 |
| 2010's | 27 (10.59) | 24.3611 |
| 2020's | 9 (3.53) | 2.80 |
| Authors | Studies |
|---|---|
| Hynes, JB; Kumar, A; Tomazic, A; Washtien, WL | 1 |
| Iijima, A; Kitoh, K; Kotake, Y; Koyanagi, N; Nomura, H; Ozawa, Y; Tamai, N; Yoshimatsu, K | 1 |
| Bhardwaj, TR; Gaba, T; Malhotra, M; Matharoo, S; Rawal, RK; Sharma, R; Singla, N | 1 |
| Anger-Góra, N; Goszczyński, TM; Mierzejewska, J; Pajtasz-Piasecka, E; Rossowska, J; Świtalska, M; Szczygieł, A; Szermer-Olearnik, B; Węgierek-Ciura, K; Wróblewska, A | 1 |
| Hamed, AA; Hanna, DH; Saad, GR | 1 |
| Goszczyński, TM; Mierzejewska, J; Pajtasz-Piasecka, E; Rossowska, J; Świtalska, M; Szczygieł, A; Szermer-Olearnik, B; Węgierek-Ciura, K; Wróblewska, A | 1 |
| Chen, S; He, JN; Liu, XQ; Nie, ZQ; Yang, CT; Yang, JM; Zhang, J; Zhao, Y; Zhu, FD | 1 |
| Alhajj, MJ; Carabali, GA; Ciro, Y; Di Virgilio, AL; Rojas, J; Salamanca, CH | 1 |
| Álvarez, MA; Álvarez-González, B; Fernández-Perales, M; Rozalen, M; Sánchez-Polo, M | 1 |
| Anger-Góra, N; Goszczyński, TM; Mierzejewska, J; Pajtasz-Piasecka, E; Rossowska, J; Świtalska, M; Szczygieł, A; Węgierek-Ciura, K | 1 |
| Cao, PS; Fu, D; Gu, LP; Li, L; Liu, JB; Ma, YS; Shi, Y; Wang, GR; Wang, HM; Wang, PY; Wu, ZJ; Zhang, HW | 1 |
| Dabrowska, M; Dabrowski, M; Sikora, E; Uram, L | 1 |
| Costa Lima, SA; Durães, L; Gaspar, A; Reis, S | 1 |
| Aniba, M; Fares, S; Karkouri, M; Lamchahab, M; Lembarki, G; Mousalli, N; Quessar, A; Regragui, M | 1 |
| Höblinger, A; Kröber, S; Streetz, K; Tschirner, F; Weber, S | 1 |
| Dabrowska, M; Rode, W; Sikora, E; Uram, L; Zielinski, Z | 1 |
| Cai, M; Chen, F; Cui, X; Fu, S; Gao, W; Guan, R; Han, Y; Hou, L; Li, C; Lv, Y; Ma, J; Meng, X; Song, Y; Wang, P; Wang, X; Zhang, H | 1 |
| Sabatier, P; Saei, AA; Wang, S; Zubarev, RA | 1 |
| Dabrowska, M; Rode, W; Skoneczny, M; Uram, L | 1 |
| Banoth, GS; Dwivedi, AK; Dwivedi, P; Malik, R; Mishra, PR; Pandey, N; Sarkar, J; Sharma, M; Verma, A | 1 |
| Bandagi, S; Brennessel, D; Dascalu, C; Valceanu, A | 1 |
| Aikawa, M; Koyama, I; Miyazawa, M; Okada, K; Okamoto, K; Toshimitsu, Y; Ueno, Y; Yamaguchi, S | 1 |
| Cho, RC; Cole, PD; Croxford, R; Ishiguro, L; Kamen, BA; Kim, SE; Kim, YI; Ly, A; Sohn, KJ | 1 |
| Bai, J; Cai, M; Chen, F; Fu, S; Guo, H; Jia, X; Jin, Y; Lee, KY; Li, C; Li, J; Liu, P; Meng, X; Qi, X; Rosales, J; Sun, W; Wang, M; Yu, J; Yu, Y; Zhang, C; Zhao, Y; Zhu, J | 1 |
| Al-Harbi, SA; Al-Saidi, HM; Bashandy, MS; Emara, AAA; Mousa, TAA | 1 |
| Demkiv, I; Lisnychuk, N; Oleshchuk, O; Soroka, Y | 1 |
| Caldas, C; García, MJ; Miró, R; Morales, C; Muñoz, M; Peinado, MA; Ribas, M | 1 |
| Botchkina, GI; Bruheim, S; Fodstad, O; Formentini, A; Gavin, E; Ju, J; Kornmann, M; Kudo, K; Song, B; Wan, Y; Wang, Y; Xi, Y | 1 |
| Hayashi, H; Kakimoto, T; Kurai, H; Mihara, A; Nakazato, T; Sanada, Y; Suzuki, K; Tachikawa, N; Yoshida, S; Yoshimura, Y | 1 |
| Barboteau, MA; Brizard, F; Guilhot, F; Levillain, P; Loyer-Lecestre, MJ; Millot, F | 1 |
| Botchkina, G; Formentini, A; Ju, J; Kornmann, M; Song, B; Titmus, MA; Wang, Y | 1 |
| de Launoit, Y; Dejonghe, MJ; Dessein, AF; Dessein, R; Dumont, P; Figeac, M; Furuichi, Y; Gespach, C; Grard, G; Hebbar, M; Huet, G; Jonckheere, N; Lecellier, CH; Lesuffleur, T; Leteurtre, E; Monté, D; Porchet, N; Prévost, G; Pruvot, FR; Stechly, L; Truant, S | 1 |
| Adan, J; Ciudad, CJ; de Almagro, MC; Hernández, JL; Mencía, N; Noé, V; Ramirez, S; Rico, I; Selga, E; Villalobos, X | 1 |
| Altman, J; Kuzel, T; Parajuli, R; Perdekamp, M; Tallman, M | 1 |
| de Francisco, R; Fernández-García, MS; García-Pravia, C; Gutiérrez-Corral, N; Riestra, S; Rodrigo, L; Rodríguez, JI; Rodríguez-Peláez, M | 1 |
| Banerjee, D; Bertino, JR; Blasberg, RG; Cai, S; de Stanchina, E; Kochetkov, T; Moroz, MA; Nair, J; Schwartz, GK; Serganova, I; Shamis, M; Wu, J | 1 |
| Dabrowska, M; Rode, W; Skoneczny, M | 1 |
| Ciudad, CJ; Mencia, N; Noé, V; Selga, E | 1 |
| Capron, C; Emile, JF; Finzi, L; Goere, D; Kraemer, A; Legagneux, J; Malafosse, R; Nordlinger, B; Noullet, S; Penna, C | 1 |
| Choi, EW; Cusack, JC; Donahue, JM; Fuchs, BC; Kasuya, H; Kawasaki, H; Kulu, Y; Kuruppu, DK; Tanabe, KK | 1 |
| Cara, L; Clerc, T; Delpero, JR; Moutardier, V; Tosini, F; Vlieghe, P | 1 |
| Jensen, AO; Mejer, J | 1 |
| NORCROSS, JW; SULLIVAN, RD; WATKINS, E | 1 |
| SULLIVAN, RD; WATKINS, E | 1 |
| GOLDGRABER, MB; KIRSNER, JB | 1 |
| SULLIVAN, RD; ZUREK, WZ | 2 |
| Fukuda, K; Hagiwara, A; Ito, T; Itoi, H; Kin, S; Nakase, Y; Otsuji, E; Sakakura, C; Shimomura, K; Sonoyama, T; Takagi, T; Ueda, Y; Yamagishi, H | 1 |
| Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z | 1 |
| Bertino, JR; Bornmann, WG; Deckert, PM; Franke, J; Keilholz, U; Old, LJ; Ritter, G; Thiel, E; Welt, S; Williams, C | 1 |
| Fujiyama, J; Fukuda, K; Hagiwara, A; Ito, T; Kin, S; Nakase, Y; Otsuji, E; Sakakura, C; Takagi, T; Yamagishi, H | 1 |
| Croxford, R; Kim, YI; Lucock, M; Moskovitz, DN; Novakovic, P; Smirnakis, F; Sohn, KJ; Yates, Z | 1 |
| Bruzzi, P; Costanzo, FD; Di Costanzo, F; Dogliotti, L; Falcone, A; Frassineti, G; Rosso, R; Sobrero, A | 1 |
| Ciudad, CJ; Noé, V; Peñuelas, S | 1 |
| Aiza, G; Morales, C; Peinado, MA; Ribas, M | 1 |
| Li, CJ; Pardee, AB; Reddy, PV; Wang, A | 1 |
| Chattopadhyay, S; Goldman, ID; Krupenko, N; Krupenko, SA; Zhao, R | 1 |
| Debono, D; Malani, AK; Olofsson, B | 1 |
| Barrett, DA; Fouladi-Nashta, AA; Halliday, N; Li, D; Sinclair, KD; Singh, R | 1 |
| Benz, C; Cadman, E; Choti, M; Newcomer, L | 1 |
| Ahmed, T; Harper, HD; Kemeny, NE; Michaelson, RA; Yip, LC | 1 |
| Markman, M | 1 |
| Heim, ME; Queisser, W | 1 |
| Bedikian, AY | 1 |
| Friedman, MA | 1 |
| Abel, U; Beyer, JH; Herrmann, R; Holzmann, K; Schmieder, A; Spehn, J; von Franqué, U | 1 |
| Coates, AS; Fox, RM; Hedley, D; Raghavan, D; Swanson, C; Tattersall, MH | 1 |
| Taguchi, T | 1 |
| Beck, TM; Curtis, PW; Hart, NE; Smith, CE; Woodard, DA | 1 |
| Koike, K; Taira, M | 1 |
| Kremer, A; Leone, BA; Macchiavelli, M; Perez, JE; Rabinovich, MG; Romero, A; Strauss, E | 1 |
| Baguley, BC; Finlay, GJ | 1 |
| Aigner, K; Hechtel, R; Merker, G; Schwemmle, K; Tonn, J; Walther, H; Wenzl, A | 1 |
| Bertino, JR; Cardenas, RM; Fernandes, DJ; Hynes, JB | 1 |
| Calman, KC; Crossling, F; Ferguson, C; George, WD; Habeshaw, T; Hutcheon, A; Kaye, SB; McArdle, C; Sangster, G; Smith, D | 1 |
| Bertino, JR; Fernandes, DJ; Hynes, JB | 1 |
| Benz, C; Cadman, E; Silverberg, M | 1 |
| Tattersall, MH | 1 |
| Bertino, JR; Sobrero, AF | 3 |
| Bertino, JR; Dube, S; Kamen, BA; Scheer, DI; Srimatkandada, S | 1 |
| Bowman, D; Levitt, M; Schacter, B; Schipper, H; Weinerman, B | 1 |
| Cooper, MR; Muss, HB; Richards, F; Spurr, CL; White, DR | 1 |
| DeVita, VT; Henney, JE; Weiss, RB | 1 |
| Berenzweig, M; Kaplan, BH; Lanham, R; Richard, J; Solan, A; Vogl, SE | 1 |
| Fritze, D; Herrmann, R; Holzmann, K; Manegold, C | 1 |
| Brunet, R; Cantrell, JE; Lagarde, C; Schein, PS; Smith, FP | 1 |
| Friedman, MA; Phillips, TL; Resser, KJ; Volberding, PA | 1 |
| Houghton, JA; Houghton, PJ; Tice, AJ | 1 |
| Ariel, IM; Padula, G | 1 |
| Sakurai, Y; Tsukagoshi, S; Tsuruo, T; Yamori, T | 1 |
| Banfi, L; Garelli, S; Schieppati, G; Valbonesi, M | 1 |
| Benz, C; Cadman, E; Choti, M; Schoenberg, M | 1 |
| Benz, C; Cadman, E | 1 |
| Buyse, M; Le Bourgeois, JP; Lévy, E; Piedbois, P | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Boyce, HW; Chen, LT; Chen, MF | 1 |
| Chandrasekaran, B; Duch, DS; Kute, TE | 1 |
| Balduyck, M; Degand, P; Dieu, MC; Grard, G; Hemon, B; Huet, G; Janin, A; Lafyatis, R; Zerimech, F | 1 |
| Barbat, A; Beaune, P; Carrière, V; Costet, P; de Waziers, I; Dussaulx, E; Lesuffleur, T; Rousset, M; Zweibaum, A | 1 |
| Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ | 1 |
| Elliott, WL; Howard, CT; Leopold, WR; Roberts, BJ | 1 |
| Banks, SD; Barrett, LL; Dickerson, S; Pendergast, W; Smith, GK; Waters, KA | 1 |
| Baratz, M; Gilat, T; Hallak, A; Halpern, Z; Rabau, M; Santo, M; Werbin, N | 1 |
| Berkel, H; Jenkins, H; Jewell, L; Spread, C; Yakimets, W | 1 |
| Dall'Olio, F; Guerrini, S; Malagolini, N; Serafini-Cessi, F | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| Braakhuis, BJ; de Jong, M; Peters, GJ; Pinedo, HM; van der Wilt, CL | 1 |
| Aschele, C; Bertino, JR; Chang, YM; Sobrero, A; Wang, FS | 1 |
| Otter, GM; Schmid, FA; Sirotnak, FM | 1 |
| Banks, S; Dev, IK; Dickerson, SH; Duch, DS; Ferone, R; Heath, LS; Humphreys, J; Knick, V; Pendergast, W; Singer, S | 1 |
| Malmberg, M; Rustum, YM; Slocum, HK; Yin, MB; Zhang, ZG | 1 |
| Akazawa, S; Amemiya, K; Fujiki, T; Futatsuki, K; Kanda, Y; Miyazaki, M; Oishi, T; Uchida, N; Yamamoto, K | 1 |
| Iida, A; Ikeda, N; Komatsu, T; Ookubo, K | 1 |
| Baumgart, F; Köpf-Maier, P; Tausch-Treml, R; Ziessow, D | 1 |
| Carlsson, G; Glimelius, B; Graf, W; Gustavsson, B; Larsson, PA | 1 |
| Anderson, NR; Lokich, JJ; Moore, CL | 2 |
| De Bolos, C; Degand, P; Delannoy, P; Emery, N; Huet, G; Kim, I; Verbert, A | 1 |
| Boiocchi, M; Corona, G; Gigante, M; Toffoli, G | 1 |
| Iwasaki, R; Kamano, T; Kobayashi, S; Matsumura, S; Ono, K; Sakamoto, K | 1 |
| Hata, K; Kaganoi, J; Nanbu, H; Nishitai, R; Ohsumi, K; Tokunaga, Y | 1 |
| Barbat, A; Cambier, D; Lesuffleur, T; Pandrea, I; Zweibaum, A | 1 |
| Agrawal, S; Bianco, AR; Bianco, R; Caputo, R; Ciardiello, F; Damiano, V; Jiang, Z; Pepe, S; Pomatico, G; Tortora, G | 1 |
| Aschele, C; Bertoglio, S; Bolli, EA; Guglielmi, AP; Mammoliti, S; Mori, AM; Rollandi, GA; Rosso, R; Sobrero, AF; Tixi, LM | 1 |
| Akutsu, M; Ando, J; Furuta, M; Kano, Y; Tsunoda, S; Yazawa, Y | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Smid, K; Smitskamp-Wilms, E | 1 |
| Bender, FC; Bron, C; Quest, AF; Reymond, MA | 1 |
| Akutsu, M; Furukawa, Y; Kano, Y; Suzuki, K; Tsunoda, S; Yazawa, Y | 1 |
| Hoffbrand, AV; Weir, DG | 1 |
| Akhurst, T; Balatoni, J; Banerjee, D; Bertino, JR; Blasberg, R; Bornmann, W; Doubrovin, M; Finn, R; Fong, Y; Gelovani Tjuvajev, J; Iwamoto, M; Larson, S; Malhotra, S; Mayer-Kuckuk, P | 1 |
| Engelhardt, P; Lorenz, R | 1 |
| Alfonso, A; Bohorquez, J; Gardner, B; Harshaw, D; Hassan, A; Herbsman, H; Newman, J | 1 |
| Louie, AC; Muggia, FM; Rozencweig, M; von Hoff, DD | 1 |
| Bedikian, A; Bodey, GP; Burgess, MA; Hersh, EM; Mavligit, GM; Rodriguez, V; Valdivieso, M | 1 |
| Klahr, C; Presant, CA; Ratkin, G | 1 |
| Desai, SA; DeWys, WD; Taylor, SG | 1 |
| Bedikian, AY; Bodey, GP; Burgess, MA; Mavligit, GM; Rodriguez, V; Valdivieso, M | 1 |
| Barnes, P; Cooper, R; Howard, V; Muss, HB; Rhyne, L; Richards, F; Spurr, CL; Stuart, JJ; White, DR | 1 |
| DeVita, VT; Weiss, RB | 1 |
| Adamoli, P; Annibali, E; Biraghi, M; Curtarelli, G; Fittipaldi, M; Licciardello, L; Scanni, A; Tomirotti, M; Trovato, M | 1 |
| Giles, GR; Hannam, TW; Kelly, JP | 1 |
| Bolton, PM | 1 |
| Hartmann, D; Obrecht, JP | 1 |
| Cooper, MR; Pajak, TL; Richards, F; Spurr, CL | 1 |
| Dencker, H; Håkansson, L; Tropé, C | 1 |
| Fujieda, S; Ohtsubo, T; Saito, H; Tanigawa, N | 1 |
| Kouri, MO; Pyrhönen, SO | 1 |
| Blomqvist, CP; Muhonen, TT; Pyrhönen, SO; Wiklund, TA | 1 |
| Barbat, A; Byrd, JC; Dahiya, R; Kim, YS; Kwak, KS; Lesuffleur, T; Zweibaum, A | 1 |
| Aschele, C; Bertino, JR; Faderan, MA; Sobrero, A | 1 |
| Grem, JL | 1 |
| Bigham, EC; Duch, DS; Ferone, R; Heath, LS; Keith, BR; Mullin, RJ; Singer, S; Waters, KA; Wilson, HR | 1 |
| Taniki, T; Weber, G; Zhen, YS | 1 |
| Calabresi, P; Darnowski, JW; Goulette, FA; Renaud, CA; Tosi, P | 1 |
| Goldenberg, DM; Shih, LB | 1 |
| Aschele, C; Bertino, JR; Nicolin, A; Rosso, R; Sobrero, A | 1 |
| Daniel, B; Ding, RW; Herrmann, R; Port, RE | 1 |
| Ahmed, M; Iqbal, MP; Mehboobali, N; Waqar, MA | 1 |
| Affleck, K; Charleston, A; Embleton, MJ | 1 |
| Bruckner, HW; Motwani, BT | 1 |
| Augeron, C; Barbat, A; Dussaulx, E; Kornowski, A; Laboisse, C; Lesuffleur, T; Zweibaum, A | 1 |
| Antoniw, P; Bagshawe, KD; Boden, JA; Boxer, GM; Patridge, TA; Pedley, RB; Sharma, K; Southall, PJ | 1 |
| Doroshow, JH; Newman, EM | 1 |
| Hutson, PR; Mutch, RS | 1 |
| Harstrick, A; Köhne-Wömpner, CH; Poliwoda, H; Schmoll, HJ; Schöber, C; Wilke, H | 1 |
| Muñoz, M; Perán, S; Saiz, MT | 1 |
| Barbat, A; Dussaulx, E; Lesuffleur, T; Zweibaum, A | 1 |
| Daniele, O; Fiorentino, MV; Fornasiero, A | 1 |
| Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G | 1 |
| Burke, P; Creaven, P; Emrich, LJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, Y; Stulc, J | 1 |
| Bertino, JR; McGuire, JJ; Sobrero, AF | 1 |
| Lönn, S; Lönn, U | 3 |
| Goldenberg, DM; Primus, FJ; Sharkey, RM; Shih, LB | 1 |
| Lönn, S; Lönn, U; Nylen, U; Winblad, G | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| Kesseler, J; Ploss, HJ; Schmitz, R; Zanea-Wangler, E | 1 |
| Bertino, JR; Nicolin, A; Romanini, A; Rosso, R; Russello, O; Sobrero, A | 1 |
| Kashani-Sabet, M; Scanlon, KJ; Sowers, LC | 1 |
| Bennett, A; Chambers, EA; Gaffen, JD | 1 |
| Bertino, JR; Dicker, AP; Volkenandt, M | 1 |
| Bunni, MA; Priest, DG; Rembiesa, BM; Sahovic, E; Stuart, R | 1 |
| Bertino, JR; Dube, S; Moroson, BA; Schweitzer, BI; Srimatkandada, S | 1 |
| Doria, MI; DuBrow, RA; Faintuch, J; Levin, B; Riddell, RH; Shepard, KV | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T | 1 |
| Bertino, JR; McGuire, JJ; Rodenhuis, S; Sawicki, WL | 1 |
| Fisher, K; Flam, M; Gandara, D; Hannigan, J; Hendrickson, C; Kohler, M; Richman, E; Valone, FH; Yu, KP | 1 |
| Geller, N; Hollander, P; Kemeny, N; Reichman, B | 1 |
| Davis, HL; Douglass, HO; Engstrom, PF; Falkson, G; Lefkopoulou, M; MacIntyre, J; Mittelman, A; Taylor, SG | 1 |
| Kanellos, J; McKenzie, IF; Pietersz, GA | 1 |
| Glimelius, B | 1 |
| Drakes, T; Eisenberg, PD; Flam, MS; Hannigan, J; Valone, FH; Wittlinger, PS | 1 |
| Beck, TM; Hart, NE; Smith, CE; Woodard, DA | 1 |
| Fujita, M; Kusuyama, T; Orikasa, H; Shimozuma, K; Taguchi, T; Usugane, M | 1 |
| Beschorner, J; Cooper, RM; DuBrow, RA; Faintuch, J; Hagle, M; Karl, RC; Levin, B; Shepard, KV; Stablein, D | 1 |
| Bertino, JR; Handschumacher, RE; Moir, RD; Sobrero, AF | 1 |
| Bertino, JR; Handschumacher, RE; Sobrero, AF | 1 |
| Armitage, NC; Baldwin, RW; Ballantyne, KC; Clegg, JA; Garnett, MC; Hardcastle, JD; Perkins, AC; Pimm, MV | 1 |
| Murakami, M; Ota, K | 2 |
| Banerjee, TK; Davis, HL; Hansen, RM; Ousley, JL; Pogodzinski, AE; Schiferl, EA; Trump, DL; Zaentz, SD | 1 |
| Hansen, RM | 1 |
| Coates, A; Mackintosh, J; Raghavan, D; Swanson, C; Tattersall, MH | 1 |
| Figueredo, A; Goodyear, M; Hryniuk, WM | 1 |
| Mackintosh, J; Tattersall, MH | 1 |
| Armitage, NC; Baldwin, RW; Ballantyne, KC; Durrant, LG; Gallego, J; Garnett, MC; Hardcastle, JD; Marksman, RA | 1 |
| Armitage, NC; Baldwin, RW; Ballantyne, K; Durrant, LG; Garnett, MC; Hardcastle, JD; Perkins, AC; Pimm, MV | 1 |
| Ginman, C; Glimelius, B; Graffman, S; Påhlman, L; Ståhle, E | 1 |
| Tominaga, T | 1 |
| Anderson, T; Hansen, RM; Ritch, PS | 1 |
| Anderson, T; Frick, J; Hansen, RM; Quebbeman, EJ; Ritch, PS | 1 |
| Flokkmann, A; Fosså, SD; Tveit, KM; Wanderås, EH | 1 |
| Cullinan, S; Everson, LK; Klaassen, DJ; O'Connell, MJ; Wieand, HS | 1 |
| Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK | 1 |
| Akazawa, S; Futatsuki, K; Kanamaru, R; Miyazaki, T; Murakami, M; Niitsu, Y; Ota, K; Sakai, Y; Wakui, A; Yokoyama, M | 1 |
| Green, MD; Muggia, FM; Subar, M; Wadler, S; Wiernik, PH | 1 |
| Almersjö, O; Berne, MH; Frösing, R; Gustavsson, BG; Spears, PC | 1 |
| Cooper, MR; Craig, JB; Jackson, DV; Muss, HB; Richards, FR; Spurr, CL; Stuart, JJ; White, DR | 1 |
| Neilan, BA | 1 |
| Ozhiganov, EL; Platinskiĭ, LV; Sokolova, VD | 1 |
| Baldwin, RW | 1 |
| Asbury, RF; Kao, AK; Muggia, FM; Wernz, JC | 1 |
| Hirota, T; Itabashi, M; Koyama, Y; Minato, K; Moriya, Y; Shimoyama, M | 1 |
| Leone, BA; Macchiavelli, M; Perez, JE; Rabinovich, MG; Romero, A; Strauss, E | 1 |
| Bazos, MJ; Evans, WK; Myers, R; Shepherd, FA; Zorzitto, ML | 1 |
| Ardizzoni, A; Canobbio, L; Nobile, MT; Rosso, R; Tatarek, R | 1 |
| Ellison, NM; Servi, RJ | 1 |
| Dias Wickramanayake, P; Klein, HO; Meyer-Hofmann, H; Pape, S | 1 |
| Ajani, JA; Bedikian, AY; Bodey, GP; Espinoza, EG; Kanojia, MD; Korinek, JK; Stein, SH | 1 |
| Ford, J; Margolese, R; Panasci, L | 1 |
| Kitaoka, H; Yoshikawa, K | 1 |
| Morgenthaler, F; Pettavel, J | 1 |
| Goldenberg, DM; Hindringer, B; Witte, S | 1 |
| Griffen, WO; Humphrey, L; Sosin, H | 1 |
| Cunningham, TJ; Horton, J; Laffin, R; Olson, KB; Sullivan, J | 1 |
| Oberfield, RA | 1 |
| Eggerth, G; Kühböck, J; Pokorny, D; Steinbach, K | 1 |
| Foley, JF; Lemon, HM; Miller, D | 1 |
| McElwain, TJ | 1 |
| Hall, TC | 1 |
| Hill, GJ; Larsen, RR | 1 |
| Hanham, IW; Priestman, TJ | 1 |
| Cohen, SM; Greenspan, EM; Weiner, MJ | 1 |
| Lokich, JJ; Skarin, AT | 1 |
| Johnston, GS; Jones, AE | 1 |
| Freckman, HA | 1 |
| Rall, DP | 1 |
| Anderson, LL; Collins, GJ; Oberfield, RA; Ojima, Y; Sullivan, RD | 1 |
| Ediger, AJ; Mason, JH | 1 |
| Edwards, AJ; Hurd, CM; Rowland, GF; Sumner, MR | 1 |
20 review(s) available for methotrexate and Colonic Neoplasms
| Article | Year |
|---|---|
Chemotherapy in alimentary tract malignomas.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Colonic Neoplasms; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Mitomycin; Mitomycins; Rectal Neoplasms; Semustine; Stomach Neoplasms; Streptozocin; Tegafur; Vincristine | 1981 |
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms; Tegafur | 1983 |
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward".
Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Rectal Neoplasms | 1983 |
[The theory and practice of chemotherapy by arterial infusion--the importance of pharmacokinetic research].
Topics: Animals; Antineoplastic Agents; Capillary Permeability; Colonic Neoplasms; Doxorubicin; Humans; Infusions, Intra-Arterial; Kinetics; Methotrexate; Neoplasms; Stomach Neoplasms | 1984 |
[Gene amplification].
Topics: Actins; Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colonic Neoplasms; Cricetinae; Dihydroorotase; DNA, Neoplasm; Drosophila melanogaster; Drug Resistance; Gene Amplification; Humans; Leukemia, Myeloid; Methotrexate; Multienzyme Complexes; Proteins; Rats; Sarcoma, Experimental; Tetrahydrofolate Dehydrogenase | 1984 |
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma | 1980 |
[Chemotherapy of metastasizing cancers of the colon and rectum].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Methotrexate; Neoplasm Metastasis; Phosphonoacetic Acid; Rectal Neoplasms | 1993 |
Cooperative antitumor effect of mixed backbone oligonucleotides targeting protein kinase A in combination with cytotoxic drugs or biologic agents.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cell Division; Cisplatin; Colonic Neoplasms; Combined Modality Therapy; Cyclic AMP-Dependent Protein Kinases; Doxorubicin; Drug Design; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Fluorouracil; Genetic Therapy; Humans; Methotrexate; Oligonucleotides, Antisense; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thionucleotides; Tumor Cells, Cultured; Vincristine | 1998 |
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Nucleosides; Nucleotides; RNA, Neoplasm; Thymidine; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Chemotherapy of advanced cancer of the colon and rectum.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms | 1991 |
Levamisole in the adjuvant treatment of colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Intestinal Absorption; Levamisole; Methotrexate | 1991 |
Modulation of cytotoxic drug activity by dipyridamole.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Cytarabine; Dipyridamole; Drug Interactions; Etoposide; Fluorouracil; Humans; Leucovorin; Methotrexate | 1990 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Doxorubicin; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methotrexate; Rectal Neoplasms; Semustine; Vincristine | 1986 |
[Current studies of sequential methotrexate and 5-fluorouracil treatment in cancer chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Rectal Neoplasms; Stomach Neoplasms | 1988 |
Biochemical modulation of fluorouracil therapy in advanced colorectal cancer.
Topics: Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Interactions; Fluorouracil; Humans; Methotrexate; Rectal Neoplasms | 1987 |
[Chemotherapy of cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Lomustine; Melphalan; Methotrexate; Rectal Neoplasms; Semustine; Vincristine | 1985 |
Monoclonal antibody targeting of anti-cancer agents: Mühlbock memorial lecture.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Binding Sites, Antibody; Carcinoembryonic Antigen; Colonic Neoplasms; Haptens; Humans; Iodine Radioisotopes; Methotrexate; Mice; Neoplasms; Ricin; Sarcoma, Experimental; Serum Albumin | 1985 |
The prognosis and management of recurrent abdominal malignancies.
Topics: Abdominal Neoplasms; Adolescent; Adult; Antineoplastic Agents; Bile Duct Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Palliative Care; Pancreatic Neoplasms; Prognosis; Rectal Neoplasms; Stomach Neoplasms; Thiotepa | 1969 |
Chemotherapy in colorectal cancer.
Topics: Carmustine; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Nitrogen Mustard Compounds; Rectal Neoplasms; Vincristine | 1973 |
Predictive tests in cancer. Tuesday 9 April 1974.
Topics: Age Factors; Breast Neoplasms; Cell Movement; Clinical Enzyme Tests; Colonic Neoplasms; Cytarabine; Diagnosis, Differential; Doxorubicin; Drug Combinations; Drug Evaluation; Drug Evaluation, Preclinical; Fluorouracil; Humans; Kinetics; Leukemia; Mercaptopurine; Methods; Methotrexate; Models, Chemical; Neoplasms; Prognosis; Sarcoma; Testosterone; Thioguanine | 1974 |
33 trial(s) available for methotrexate and Colonic Neoplasms
| Article | Year |
|---|---|
Adjuvant sequential methotrexate --> 5-fluorouracil vs 5-fluorouracil plus leucovorin in radically resected stage III and high-risk stage II colon cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Combined Modality Therapy; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Survival Rate | 2005 |
Activity of sequential low-dose methotrexate and fluorouracil in advanced colorectal carcinoma: attempt at correlation with tissue and blood levels of phosphoribosylpyrophosphate.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Lymphocytes; Male; Methotrexate; Middle Aged; Mucous Membrane; Nausea; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Prospective Studies; Rectal Neoplasms; Ribose-Phosphate Pyrophosphokinase; Thrombocytopenia; Vomiting | 1984 |
Newer techniques in cancer chemotherapy.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Cells, Cultured; Child; Cisplatin; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Hepatic Artery; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Mechlorethamine; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Osteosarcoma; Peritoneal Cavity; Pleura | 1984 |
Combination therapy with methotrexate and 5-fluorouracil: a prospective randomized clinical trial of order of administration.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prognosis; Random Allocation; Rectal Neoplasms; Stomach Neoplasms | 1984 |
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Head and Neck Neoplasms; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Purines; Random Allocation; Thymidine | 1983 |
Therapy of advanced colorectal carcinoma with 5-fluorouracil and cyclophosphamide in combination with either CCNU or methotrexate.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Remission, Spontaneous; Time Factors | 1980 |
Advances in the multimodal primary management of cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Osteosarcoma | 1980 |
Sequential chemotherapy of advanced colorectal cancer with standard or high-dose methotrexate followed by 5-fluorouracil.
Topics: Aged; Clinical Trials as Topic; Colonic Neoplasms; Digestive System; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Leukopenia; Liver Neoplasms; Lung Neoplasms; Methotrexate; Middle Aged; Rectal Neoplasms; Uremia | 1982 |
[Possible effect of administration methods on pharmacological action. Study of cytostatic therapy in advanced cancer].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Retrospective Studies | 1995 |
Postsurgical sequential methotrexate, fluorouracil, and leucovorin for advanced colorectal carcinoma: a preliminary study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Mitomycin; Postoperative Period; Rectal Neoplasms; Survival Rate; Tegafur; Uracil | 1997 |
Schedule-selective biochemical modulation of 5-fluorouracil: a phase II study in advanced colorectal cancer.
Topics: Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1995 |
Phase II study of mitomycin C, cyclophosphamide, and methotrexate in drug-resistant colorectal carcinoma.
Topics: Adenocarcinoma; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Mitomycins; Rectal Neoplasms | 1978 |
Phase II trial of a combination of cyclosphamide, vincristine, and methotrexate in advanced colorectal carcinoma.
Topics: Adult; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Vincristine | 1978 |
Sequential chemoimmunotherapy of colorectal cancer: evaluation of methotrexate, Baker's Antifol and levamisole.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Levamisole; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Remission, Spontaneous; Semustine; Time Factors; Triazines | 1978 |
Chemotherapy versus chemoimmunotherapy in advanced adenocarcinoma of the colon and rectum: a prospective randomized study.
Topics: Adenocarcinoma; Antineoplastic Agents; BCG Vaccine; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Remission, Spontaneous; Semustine; Skin Ulcer; Time Factors; Vincristine | 1979 |
The dilemma regarding postoperative chemotherapy in primary carcinoma of the colon.
Topics: Antineoplastic Agents; BCG Vaccine; Breast Neoplasms; Carcinoma; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Mycobacterium bovis; Neoplasm Metastasis; Postoperative Care; Semustine; Vincristine | 1979 |
Phase II study of epirubicin sequential methotrexate and 5-fluorouracil for advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1992 |
Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Surface Area; Breast Neoplasms; Colonic Neoplasms; Esophageal Neoplasms; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms; Rectal Neoplasms; Sex Characteristics | 1991 |
Levamisole in the adjuvant treatment of colon cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Intestinal Absorption; Levamisole; Methotrexate | 1991 |
A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Palliative Care; Prospective Studies; Random Allocation; Rectal Neoplasms | 1987 |
A Northern California Oncology Group randomized trial of leucovorin plus 5-fluorouracil versus sequential methotrexate, 5-fluorouracil, and leucovorin in patients with advanced colorectal cancer who failed treatment with 5-fluorouracil or 5-fluorodeoxyuri
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Resistance; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Rectal Neoplasms | 1987 |
Implementation of the group sequential methodology in a randomized trial in metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Leukocyte Count; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Random Allocation; Semustine; Streptozocin; Vincristine | 1988 |
Systemic cytostatic drug therapy in liver cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Doxorubicin; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methotrexate; Rectal Neoplasms; Semustine; Vincristine | 1986 |
A northern California Oncology Group randomized trial of single agent 5-FU vs. high-dose folinic acid + 5-FU vs. methotrexate + 5-FU + folinic acid in patients with disseminated measurable large bowel cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Random Allocation | 1988 |
Sequential 5-fluorouracil, methotrexate, and calcium leucovorin in metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1988 |
Systemic therapy of colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Leucovorin; Methotrexate; Neoplasm Metastasis; Rectal Neoplasms | 1988 |
Chemotherapy of advanced colorectal cancer. A randomized trial of sequential methotrexate and 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Random Allocation; Rectal Neoplasms; Time Factors | 1987 |
Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Fluorouracil; Humans; Methotrexate; Random Allocation; Rectal Neoplasms | 1987 |
Clinical studies of biochemical modulation of 5-fluorouracil by leucovorin in patients with advanced colorectal cancer by the North Central Cancer Treatment Group and Mayo Clinic.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Hematopoiesis; Humans; Leucovorin; Methotrexate; Prospective Studies; Rectal Neoplasms | 1987 |
Low dosage methotrexate (NSC-740) and cyclophosphamide (NSC 26271) for solid tumors.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Melanoma; Methotrexate; Middle Aged; Nausea; Neoplasms; Radiography; Rectal Neoplasms; Stomatitis; Wilms Tumor | 1970 |
Remission induction in childhood leukemia with second course vincristine (NSC-67574) and prednisone (NSC-10023) therapy.
Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1970 |
Comparison of antimetabolites in the treatment of breast and colon cancer.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antimetabolites; Breast Neoplasms; Child; Clinical Trials as Topic; Colonic Neoplasms; Female; Fluorouracil; Humans; Longevity; Methotrexate; Middle Aged; Rectal Neoplasms; Riboflavin | 1967 |
Pharmacologic studies of methotrexate in cancer patients with uropathy.
Topics: Colonic Neoplasms; Humans; Injections, Intravenous; Kidney Diseases; Kidney Function Tests; Methotrexate; Neoplasms; Pelvic Neoplasms; Tritium | 1970 |
205 other study(ies) available for methotrexate and Colonic Neoplasms
| Article | Year |
|---|---|
Synthesis of 5-chloro-5,8-dideaza analogues of folic acid and aminopterin targeted for colon adenocarcinoma.
Topics: Adenocarcinoma; Aminopterin; Cell Line; Chemical Phenomena; Chemistry; Colonic Neoplasms; Humans; Quinazolines; Structure-Activity Relationship | 1987 |
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Colonic Neoplasms; Folic Acid Antagonists; Glutamates; Humans; Leukemia P388; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Design, synthesis and ex vivo evaluation of colon-specific azo based prodrugs of anticancer agents.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Design; Drug-Related Side Effects and Adverse Reactions; Feces; Humans; Inhibitory Concentration 50; Mesalamine; Prodrugs; Rats | 2013 |
Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma.
Topics: Animals; Cancer Vaccines; Carcinoma; Colonic Neoplasms; Dendritic Cells; Lymphocyte Activation; Methotrexate; Mice; Nanoconjugates; Receptors, Interleukin-10; RNA, Small Interfering; Tumor Microenvironment | 2023 |
Synthesis and characterization of poly(3-hydroxybutyrate)/chitosan-graft poly (acrylic acid) conjugate hyaluronate for targeted delivery of methotrexate drug to colon cancer cells.
Topics: 3-Hydroxybutyric Acid; Caco-2 Cells; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Humans; Hyaluronic Acid; Methotrexate; Pharmaceutical Preparations; Polymers | 2023 |
Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines.
Topics: Animals; Cancer Vaccines; Colonic Neoplasms; Cytokines; Dendritic Cells; Immunotherapy; Interleukin-10; Interleukin-12; Interleukin-15; Interleukin-18; Methotrexate; Mice; Nanoconjugates; Tumor Microenvironment | 2023 |
Facile Fabrication of Dual-Activatable Gastrointestinal-Based Nanocarriers for Safe Delivery and Controlled Release of Methotrexate.
Topics: Colonic Neoplasms; Delayed-Action Preparations; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Tumor Microenvironment | 2023 |
Production, physicochemical characterization, and anticancer activity of methotrexate-loaded phytic acid-chitosan nanoparticles on HT-29 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Chitosan; Colonic Neoplasms; Drug Carriers; Drug Liberation; Gels; HT29 Cells; Humans; Methotrexate; Nanoparticles; Phytic Acid | 2020 |
Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells.
Topics: A549 Cells; Annexin A5; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Delivery Systems; Drug Liberation; Folic Acid; Gold; HCT116 Cells; Humans; Hydrogen-Ion Concentration; Lung; Lung Neoplasms; Metal Nanoparticles; Methotrexate; Tumor Microenvironment | 2020 |
Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell‑based vaccines in murine colon carcinoma.
Topics: Animals; Cancer Vaccines; Carcinoma; Cell Line, Tumor; Colon; Colonic Neoplasms; Combined Modality Therapy; Dendritic Cells; Disease Models, Animal; Drug Carriers; Female; Humans; Hydroxyethyl Starch Derivatives; Intestinal Mucosa; Methotrexate; Mice; Nanoconjugates; Tumor Escape | 2021 |
Cancer-associated fibroblast-derived exosomal microRNA-24-3p enhances colon cancer cell resistance to MTX by down-regulating CDX2/HEPH axis.
Topics: Aged; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cancer-Associated Fibroblasts; CDX2 Transcription Factor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Exosomes; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Prognosis; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling.
Topics: Antigen Presentation; beta Catenin; Cell Line, Tumor; Cellular Senescence; Colonic Neoplasms; Humans; Methotrexate; Neoplasm Proteins; Signal Transduction; Transcription Factor AP-1 | 2021 |
Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells.
Topics: Caco-2 Cells; Colonic Neoplasms; Drug Delivery Systems; Humans; Hyperthermia, Induced; Methotrexate; Nanospheres; Polyesters; Polyethylene Glycols | 2017 |
[Primary colonic extranasal NK/T-cell lymphoma: about a case].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Colonic Neoplasms; Dexamethasone; Humans; Lymphoma, Extranodal NK-T-Cell; Male; Methotrexate; Prognosis | 2017 |
[Leptomeningeal carcinomatosis as a rare metastatic spreading of BRAF-mutated microsatellite stable colon cancer].
Topics: Antineoplastic Agents; Colonic Neoplasms; Fatal Outcome; Humans; Meningeal Carcinomatosis; Methotrexate; Microsatellite Repeats; Proto-Oncogene Proteins B-raf | 2017 |
Oxidative stress and inhibition of nitric oxide generation underlie methotrexate-induced senescence in human colon cancer cells.
Topics: Cell Line, Tumor; Cellular Senescence; Colonic Neoplasms; DNA Breaks, Double-Stranded; Humans; Methotrexate; Neoplasm Proteins; Oxidative Stress | 2018 |
Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate-resistant colon cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Nucleus; Chromosome Aberrations; Chromosomes; Colonic Neoplasms; DNA Breaks, Double-Stranded; Drug Resistance, Neoplasm; Gene Amplification; Homologous Recombination; HT29 Cells; Humans; Methotrexate | 2019 |
Dynamic Proteomics Reveals High Plasticity of Cellular Proteome: Growth-Related and Drug-Induced Changes in Cancer Cells are Comparable.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Plasticity; Cell Proliferation; Colonic Neoplasms; Humans; Methotrexate; Paclitaxel; Proteome; Tumor Cells, Cultured | 2018 |
Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations.
Topics: Acetylation; Antimetabolites, Antineoplastic; Cellular Senescence; Chromosome Aberrations; Colonic Neoplasms; Genomics; Humans; Methotrexate; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2019 |
Folic acid conjugated guar gum nanoparticles for targeting methotrexate to colon cancer.
Topics: Animals; Caco-2 Cells; Calorimetry, Differential Scanning; Cell Survival; Colonic Neoplasms; Cross-Linking Reagents; Drug Delivery Systems; Folic Acid; Galactans; Humans; Magnetic Resonance Spectroscopy; Mannans; Methotrexate; Nanoparticles; Particle Size; Plant Gums; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2013 |
New therapies, increased risk for old infections--abdominal tuberculosis mimicking colon cancer during adalimumab treatment for rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Colonic Neoplasms; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Peritonitis, Tuberculous; Risk Factors | 2013 |
Thoracoscopic hepatectomy for malignant liver tumor.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Hepatectomy; Humans; Japan; Liver Neoplasms; Male; Methotrexate; Operative Time; Thoracoscopy; Vincristine | 2014 |
γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Folic Acid; gamma-Glutamyl Hydrolase; HCT116 Cells; Humans; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays | 2013 |
Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells.
Topics: Cell Proliferation; Colonic Neoplasms; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Drug Resistance, Neoplasm; Gene Amplification; HT29 Cells; Humans; Methotrexate; Staining and Labeling | 2015 |
Synthesis, spectroscopic properties, molecular docking, anti-colon cancer and anti-microbial studies of some novel metal complexes for 2-amino-4-phenylthiazole derivative.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Catalytic Domain; Cell Death; Chlorocebus aethiops; Colonic Neoplasms; Coordination Complexes; Electron Spin Resonance Spectroscopy; Electrons; Fungi; HCT116 Cells; Humans; Ligands; Mass Spectrometry; Metals; Methotrexate; Microbial Sensitivity Tests; Molecular Docking Simulation; Proton Magnetic Resonance Spectroscopy; Schiff Bases; Spectrophotometry, Infrared; Tetrahydrofolate Dehydrogenase; Thermogravimetry; Thiazoles; Vero Cells; Vibration | 2015 |
SORPTION CORRECTION OF NEPHRON SUB-MICROSCOPIC CHANGES CAUSED BY NEOPLASTIC CHRONIC INTOXICATION WITH THE APPLICATION OF CYTOSTATIC THERAPY.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adsorption; Animals; Antineoplastic Agents; Carbon; Colonic Neoplasms; Doxorubicin; Male; Methotrexate; Microcirculation; Nephrons; Rats | 2017 |
Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells.
Topics: Base Sequence; Chromosome Breakage; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 8; Clone Cells; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Amplification; Gene Dosage; HT29 Cells; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase | 2009 |
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Genes, p53; HCT116 Cells; Humans; Methotrexate; MicroRNAs; Osteosarcoma; Transfection; Tumor Cells, Cultured; Up-Regulation | 2009 |
[Successful treatment with hyper-CVAD and highly active anti-retroviral therapy (HAART) for AIDS-related Burkitt lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Burkitt Lymphoma; Colonic Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Etoposide; Humans; Lymphoma, AIDS-Related; Male; Methotrexate; Prednisone; Treatment Outcome; Vincristine | 2010 |
Endoscopic diagnosis of childhood Burkitt's lymphoma of the colon.
Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Colonic Neoplasms; Colonoscopy; Cyclophosphamide; Cytarabine; Female; Humans; Methotrexate | 2010 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methotrexate; MicroRNAs; Middle Aged; Nuclear Proteins; Osteosarcoma; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Transfection; Ubiquitin-Protein Ligases | 2010 |
Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.
Topics: Animals; Colonic Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Profiling; Gene Silencing; HT29 Cells; Humans; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Methotrexate; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Phenotype; Receptors, CXCR4; Signal Transduction; Up-Regulation | 2010 |
Overexpression of S100A4 in human cancer cell lines resistant to methotrexate.
Topics: Antimetabolites, Antineoplastic; beta Catenin; Blotting, Western; Caco-2 Cells; Cell Survival; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Methotrexate; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; S100 Calcium-Binding Protein A4; S100 Proteins; Transcription, Genetic; Transfection; Up-Regulation | 2010 |
Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Colonic Neoplasms; Colonic Polyps; Cytarabine; Daunorubicin; Doxorubicin; Female; Humans; Idarubicin; Indoles; Kidney Neoplasms; Leukemia, Promyelocytic, Acute; Lung Neoplasms; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms, Second Primary; Pyrroles; Remission Induction; Sunitinib; Time Factors; Tretinoin | 2010 |
Kaposi's sarcoma: an opportunistic infection by human herpesvirus-8 in ulcerative colitis.
Topics: Aged; Colitis, Ulcerative; Colonic Neoplasms; Herpesvirus 8, Human; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Male; Methotrexate; Opportunistic Infections; Prednisone; Sarcoma, Kaposi | 2010 |
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Fluorouracil; HCT116 Cells; Humans; Immunoblotting; Ki-67 Antigen; Methotrexate; Mice; Mice, Nude; Organophosphates; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Xenograft Model Antitumor Assays | 2011 |
Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cellular Senescence; Colonic Neoplasms; Gene Expression Profiling; Humans; Methotrexate; Microarray Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2011 |
Underexpression of miR-224 in methotrexate resistant human colon cancer cells.
Topics: 3' Untranslated Regions; Antimetabolites, Antineoplastic; Caco-2 Cells; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; K562 Cells; Lectins; Methotrexate; MicroRNAs; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Bicarbonate Symporters | 2011 |
Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Aphidicolin; Apoptosis; Cell Culture Techniques; Cell Cycle; Colonic Neoplasms; Cytarabine; Flow Cytometry; Ganciclovir; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Methotrexate; Mice; Retroviridae; Simplexvirus; Thymidine Kinase; Tumor Cells, Cultured | 2011 |
Concurrent chemotherapy inhibits herpes simplex virus-1 replication and oncolysis.
Topics: Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Herpesvirus 1, Human; Humans; Irinotecan; Methotrexate; NF-kappa B; Oncolytic Virotherapy; Oncolytic Viruses; Pancreatic Neoplasms; Transcriptional Activation; Tumor Necrosis Factor-alpha; Virus Replication | 2013 |
Colloidal anticancer drugs bioavailabilities in oral administration models.
Topics: Animals; Antineoplastic Agents; Biological Availability; Biological Transport; Caco-2 Cells; Colloids; Colon; Colonic Neoplasms; Drug Stability; Female; Fluorouracil; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; L-Lactate Dehydrogenase; Liposomes; Male; Methotrexate; Nanotechnology; Rats; Rats, Wistar; Tissue Distribution; Vincristine | 2003 |
Remission of methotrexate-resistant rheumatoid arthritis after receiving 5-fluorouracil for colon cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Colonic Neoplasms; Drug Resistance; Fluorouracil; Humans; Male; Methotrexate; Remission Induction | 2003 |
CHEMOTHERAPY OF METASTATIC LIVER CANCER BY PROLONGED HEPATIC-ARTERY INFUSION.
Topics: Alkaline Phosphatase; Bile Duct Neoplasms; Bilirubin; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Erythrocyte Count; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Sulfobromophthalein; Transaminases; Uterine Cervical Neoplasms | 1964 |
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neoplasms; Floxuridine; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Pelvic Neoplasms; Skull Neoplasms; Tongue Neoplasms | 1964 |
CARCINOMA OF THE COLON IN ULCERATIVE COLITIS.
Topics: Aged; Aging; Cell Biology; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Fluorouracil; Humans; Mechlorethamine; Methotrexate; Neoplasms; Pathology; Polyps; Radiography; Surgical Procedures, Operative | 1964 |
PROTRACTED AMBULATORY INFUSION CANCER CHEMOTHERAPY BY THE WATKINS CHRONOMETRIC INFUSOR.
Topics: Adenoma; Antineoplastic Agents; Breast Neoplasms; Carcinosarcoma; Colonic Neoplasms; Dermatitis, Exfoliative; Equipment and Supplies; Floxuridine; Fluorouracil; Humans; Infusion Pumps; Infusions, Parenteral; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mitomycin; Mitomycins; Pancreatic Neoplasms; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms; Tongue Neoplasms; Toxicology | 1964 |
[Intratumoral administration of methotrexate bound to activated carbon particles (MTX-CH) inducing antitumor effect in vivo].
Topics: Animals; Antimetabolites, Antineoplastic; Carbon; Colonic Neoplasms; Delayed-Action Preparations; Female; Injections, Intralesional; Methotrexate; Mice; Mice, Inbred BALB C; Specific Pathogen-Free Organisms | 2003 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosine; DNA Probes; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Humans; Leucovorin; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Polymorphism, Genetic; Random Allocation; Thymidylate Synthase; Thymine; Transfection; Transplantation, Heterologous; Valine | 2004 |
Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carboxypeptidases A; Colonic Neoplasms; Female; Humans; Iodine Radioisotopes; Membrane Glycoproteins; Methotrexate; Mice; Mice, Nude; Phenylalanine; Prodrugs; Survival Rate; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
Intratumoral administration of methotrexate bound to activated carbon particles: antitumor effectiveness against human colon carcinoma xenografts and acute toxicity in mice.
Topics: Animals; Autopsy; Body Weight; Charcoal; Colonic Neoplasms; Humans; Lethal Dose 50; Male; Methotrexate; Mice; Mice, Inbred BALB C; Phenotype; Xenograft Model Antitumor Assays | 2004 |
Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Division; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; Humans; Methotrexate; Peptide Synthases; Transfection; Tumor Cells, Cultured | 2004 |
Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Base Sequence; Blotting, Western; Colonic Neoplasms; DNA Primers; DNA Topoisomerases, Type I; DNA, Complementary; HT29 Cells; Humans; IMP Dehydrogenase; Inhibitor of Apoptosis Proteins; Methotrexate; Microtubule-Associated Proteins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Vimentin | 2005 |
Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Chromosomes, Human, Pair 5; Colonic Neoplasms; Drug Resistance, Neoplasm; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Methotrexate | 2005 |
Cancer chemotherapy by deoxynucleotide depletion and E2F-1 elevation.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cisplatin; Colonic Neoplasms; DNA Replication; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Humans; Male; Methotrexate; Nucleotides; Prostatic Neoplasms; Transcription Factors | 2005 |
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 2006 |
Remission of hepatic metastasis from colon cancer after methotrexate withdrawal.
Topics: Adenocarcinoma, Mucinous; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Colectomy; Colonic Neoplasms; Humans; Liver Neoplasms; Lymphocyte Activation; Male; Methotrexate; T-Lymphocytes, Cytotoxic; Tomography, X-Ray Computed | 2006 |
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Topics: Adenocarcinoma; Adenosine; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Cyclic AMP; Extracellular Signal-Regulated MAP Kinases; HT29 Cells; Humans; Hypoxanthines; MAP Kinase Kinase Kinases; Methionine; Methotrexate; Phosphatidylinositol 3-Kinases; Polyamines; Purines; Signal Transduction; Tetrahydrofolates; Thymidine | 2006 |
Thymidine enhancement of methotrexate and 5-fluorouracil toxicity in cultured human colon carcinoma.
Topics: Cells, Cultured; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Humans; Kinetics; Methotrexate; RNA; Thymidine | 1984 |
Sequential methotrexate and 5-fluorouracil: improved response rate in metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptions; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Humans; Leukopenia; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Peripheral Nervous System Diseases; Rectal Neoplasms | 1984 |
Treatment of metastatic colorectal carcinoma with 5-FU, mitomycin, vincristine, and methotrexate.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasm Metastasis; Rectal Neoplasms; Thrombocytopenia; Vincristine | 1984 |
Sequential combination chemotherapy with methotrexate and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1984 |
The use of human cancer cell lines as a primary screening system for antineoplastic compounds.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Female; Fluorouracil; Humans; Leukemia; Methotrexate; Neoplasms | 1984 |
First experimental and clinical results of isolated liver perfusion with cytotoxics in metastases from colorectal primary.
Topics: Animals; Antineoplastic Agents; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Dacarbazine; Dogs; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Rectal Neoplasms | 1983 |
Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; DNA Replication; Drug Resistance; Female; Humans; Kinetics; Leukemia; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Peptide Synthases; Quinazolines; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1983 |
Sequential methotrexate plus 5-FU in advanced breast and colorectal cancers: a phase II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Rectal Neoplasms | 1984 |
Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Female; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase | 1983 |
Use of high-dose oral methotrexate sequenced at 24 hours with 5-FU: a clinical toxicity study.
Topics: Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Neoplasms | 1983 |
Sequence-dependent synergism between dichloromethotrexate and 5-fluorouracil in a human colon carcinoma cell line.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Methotrexate; Time Factors | 1983 |
Organization of the methotrexate resistant mouse L5178YR dihydrofolate reductase gene and transformation of human HCT-8 cells by this gene.
Topics: Animals; Base Sequence; Cell Line; Colonic Neoplasms; Drug Resistance; Gene Amplification; Genes, Regulator; Genetic Engineering; Humans; Leukemia L5178; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Transformation, Genetic | 1981 |
Sequential methotrexate and 5-FU in the treatment of colorectal cancer.
Topics: Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Humans; Injections, Intravenous; Leucovorin; Methotrexate; Rectal Neoplasms | 1982 |
[Sequential methotrexate and fluorouracil in metastasizing colorectal carcinomas. Results of a phase II pilot study (author's transl)].
Topics: Adult; Aged; Colonic Neoplasms; Female; Fluorouracil; Humans; Life Expectancy; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms; Time Factors | 1982 |
Phase II study of sequential methotrexate-5-FU therapy in advanced measurable colorectal cancer.
Topics: Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Humans; Injections, Intravenous; Methotrexate; Neoplasm Metastasis; Rectal Neoplasms | 1982 |
Therapy of liver tumors metastatic from colorectal cancer with whole-liver radiation combined with 5-FU, adriamycin, and methotrexate.
Topics: Aged; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1982 |
The selectivity of action of methotrexate in combination with 5-fluorouracil in xenografts of human colon adenocarcinomas.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Methotrexate; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Thymectomy; Time Factors | 1982 |
Treatment of asymptomatic metastatic cancer to the liver from primary colon and rectal cancer by the intraarterial administration of chemotherapy and radioactive isotopes.
Topics: Antineoplastic Agents; Catheters, Indwelling; Cisplatin; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intra-Arterial; Liver Neoplasms; Methotrexate; Prognosis; Rectal Neoplasms; Yttrium Radioisotopes | 1982 |
Enhanced cytocidal action of methotrexate by conjugation to concanavalin A.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Concanavalin A; Methotrexate; Mice; Neoplasms, Experimental | 1980 |
Defective function of granulocytes in patients with cancer.
Topics: Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Granulocytes; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Uterine Neoplasms | 1981 |
Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Cell Line; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Methotrexate | 1980 |
Modulation of 5-fluorouracil metabolism and cytotoxicity by antimetabolite pretreatment in human colorectal adenocarcinoma HCT-8.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Fluorouracil; Humans; Methotrexate; Rectal Neoplasms | 1981 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Effect of 5-fluorouracil on methotrexate transport and cytotoxicity in HT29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; Biological Transport; Colonic Neoplasms; Drug Administration Schedule; Drug Synergism; Fluorouracil; Glutathione; Humans; Intracellular Fluid; Methotrexate; Tumor Cells, Cultured | 1995 |
Synchronization of cells in the S phase of the cell cycle by 3'-azido-3'-deoxythymidine: implications for cell cytotoxicity.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Division; Cell Survival; Colonic Neoplasms; Computer Simulation; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Fluorouracil; Humans; Leukemia; Melanoma; Methotrexate; Pancreatic Neoplasms; S Phase; Tumor Cells, Cultured; Zidovudine | 1995 |
The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
Topics: Carcinoma; Cathepsin B; Cathepsin D; Cell Differentiation; Cell Line; Colonic Neoplasms; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Methotrexate; Mucus; Plasminogen Activators; Tumor Cells, Cultured | 1994 |
Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7.
Topics: Blotting, Northern; Blotting, Western; Carcinoma; Cell Compartmentation; Cell Differentiation; Clone Cells; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Drug Resistance; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mixed Function Oxygenases; RNA, Messenger; Selection, Genetic; Tumor Cells, Cultured | 1994 |
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured | 1994 |
Chemotherapy with [SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2- methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in combination with standard agents against murine tumors in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Drug Screening Assays, Antitumor; Etoposide; Ifosfamide; Leukemia P388; Mammary Neoplasms, Animal; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Sarcoma, Experimental; Vinblastine | 1994 |
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Topics: Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1994 |
Ileitis after colectomy for ulcerative colitis or carcinoma.
Topics: Adult; Aged; Aminosalicylic Acids; Azathioprine; Colectomy; Colitis, Ulcerative; Colonic Neoplasms; Female; Humans; Ileitis; Ileum; Male; Mesalamine; Methotrexate; Middle Aged; Postoperative Complications | 1994 |
Colon carcinoid tumors. A population-based study.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Staging; Prognosis; Streptozocin; Survival Rate | 1994 |
Resistance to methotrexate is associated with selective changes of alpha 2,6- and alpha 2,3-sialyltransferase activities toward N-acetyllactosaminic sequences in human colon cancer cell line HT-29.
Topics: beta-D-Galactoside alpha 2-6-Sialyltransferase; beta-Galactoside alpha-2,3-Sialyltransferase; Carbohydrate Conformation; Carbohydrate Sequence; Cell Division; Cell Line; Cell Membrane; Colonic Neoplasms; Drug Resistance; Flow Cytometry; Humans; Kinetics; Lectins; Methotrexate; Molecular Sequence Data; Oligosaccharides; Plant Lectins; Ribosome Inactivating Proteins; Sialyltransferases; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Leucovorin; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.
Topics: Adenocarcinoma; Base Sequence; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Fluorouracil; Humans; Methotrexate; Molecular Sequence Data; Peptide Synthases; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1993 |
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
Topics: Adenocarcinoma; Aminopterin; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibrosarcoma; Leucovorin; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Salvage Therapy | 1993 |
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Colonic Neoplasms; Female; Humans; Indoles; Isoindoles; Leucovorin; Leukemia L1210; Leukemia, T-Cell; Methotrexate; Quinazolines; Structure-Activity Relationship; Subrenal Capsule Assay; Tetrahydrofolates; Thymidylate Synthase | 1993 |
Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
[A new sequential chemotherapy of methotrexate with 5-fluorouracil against advanced colo-rectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Retrospective Studies; Survival Rate | 1993 |
[A case of advance colon cancer responding to sequential methotrexate and 5-fluorouracil therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Middle Aged; Remission Induction; Tegafur; Uracil | 1993 |
5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Fluorine Radioisotopes; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Nude; Pharyngeal Neoplasms; Thymidine; Transplantation, Heterologous | 1996 |
Comparison of costs for infusion versus bolus chemotherapy administration: analysis of five standard chemotherapy regimens in three common tumors--Part one. Model projections for cost based on charges.
Topics: Antibiotics, Antineoplastic; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Costs and Cost Analysis; Cyclophosphamide; Disposable Equipment; Doxorubicin; Drug Costs; Etoposide; Fees, Medical; Fees, Pharmaceutical; Female; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Methotrexate; Models, Economic; Prednisone; Survival Rate; Vincristine | 1996 |
Comparison of costs for infusion versus bolus chemotherapy administration--Part two. Use of charges versus reimbursement for cost basis.
Topics: Antibiotics, Antineoplastic; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Costs and Cost Analysis; Cyclophosphamide; Doxorubicin; Fees, Pharmaceutical; Female; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Medicare; Methotrexate; Prednisone; Private Practice; Reimbursement Mechanisms; United States; Vincristine | 1996 |
Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.
Topics: Acetylgalactosamine; Antigens, Viral, Tumor; Benzyl Compounds; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Galactose; Galactosyltransferases; Glycosylation; HT29 Cells; Humans; Methotrexate; Molecular Sequence Data; Monosaccharides; Mucins; Neuraminidase; Sialic Acids; Sialyltransferases | 1996 |
Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; G2 Phase; Humans; Methotrexate; Microscopy, Fluorescence; S Phase; Tumor Cells, Cultured; Verapamil | 1996 |
[A case of gastric malignant lymphoma with perforation during chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms; Prednisolone; Rupture, Spontaneous; Splenic Neoplasms; Stomach Neoplasms; Stomach Rupture; Vincristine | 1997 |
Resistance of the human colon carcinoma cell line HCT-8 to methotrexate results in selection of cells with features of enterocytic differentiation.
Topics: Animals; Carrier Proteins; Cell Differentiation; Cell Division; Colonic Neoplasms; Dipeptidyl Peptidase 4; Drug Resistance, Neoplasm; Fluorescent Antibody Technique, Indirect; Humans; Methotrexate; Mice; Mice, Nude; Microfilament Proteins; Microscopy, Electron; Mucin-1; Neoplasm Transplantation; Tumor Cells, Cultured | 1998 |
Schedule-dependent synergism and antagonism between paclitaxel and methotrexate in human carcinoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Ovarian Neoplasms; Paclitaxel; Tumor Cells, Cultured | 1998 |
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
Topics: Blotting, Western; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Immunohistochemistry; Indoles; Inhibitory Concentration 50; Isoindoles; Methotrexate; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Carcinoma; Caveolin 1; Caveolins; Colon; Colonic Neoplasms; Dogs; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intestinal Mucosa; Methotrexate; Mice; Mice, Nude; Neoplasm Metastasis; Transfection; Tumor Cells, Cultured | 2000 |
Schedule-dependent synergism and antagonism between raltitrexed ("Tomudex") and methotrexate in human colon cancer cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Quinazolines; Thiophenes; Tumor Cells, Cultured | 2001 |
The history of folic acid.
Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency | 2001 |
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Ganciclovir; Gene Expression Regulation; Herpesvirus 1, Human; Humans; Methotrexate; Mice; Neoplasm Transplantation; Rats; Recombinant Fusion Proteins; Retroviridae; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Tomography, Emission-Computed; Transduction, Genetic; Transplantation, Heterologous; Trimetrexate; Tumor Cells, Cultured | 2002 |
Cytostatic treatment of meningeal blastoses.
Topics: Breast Neoplasms; Colonic Neoplasms; Dysgerminoma; Female; Humans; Injections, Spinal; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasm Metastasis | 1979 |
Treatment of hepatic metastases with a combination of hepatic artery infusion chemotherapy and external radiotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Catheterization; Cobalt Radioisotopes; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1978 |
Current trends and prospects in surgical adjuvant trials.
Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Dianhydrogalactitol; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Rectal Neoplasms | 1978 |
Chemoimmunotherapy of metastatic large bowel cancer: nonspecific stimulation with BCG and levamisole.
Topics: BCG Vaccine; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Humans; Levamisole; Lomustine; Methotrexate; Neoplasm Metastasis; Rectal Neoplasms; Tegafur | 1977 |
Variations in serum copper and ceruloplasmin levels in advanced gastrointestinal cancer treated with polychemotherapy.
Topics: Aged; Antineoplastic Agents; Ceruloplasmin; Colonic Neoplasms; Copper; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Methotrexate; Middle Aged; Prognosis; Stomach Neoplasms | 1979 |
The cytocidal action of metronidazole in combination with other antineoplastic agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Hypoxia; Methotrexate; Metronidazole; Mice; Neoplasms, Experimental | 1979 |
Chemotherapy, immunotherapy and chemoimmunotherapy of colorectal cancer.
Topics: Colonic Neoplasms; Fluorouracil; Humans; Immunotherapy; Lomustine; Methotrexate; Mitomycins; Rectal Neoplasms | 1977 |
[Current state of therapy for gastrointestinal tumors].
Topics: Carmustine; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; Humans; Methotrexate; Pancreatic Neoplasms; Prognosis; Remission, Spontaneous; Stomach Neoplasms; Vincristine | 1978 |
Comparison of 5-fluorouracil with 5-fluorouracil, cyclophosphamide, and methotrexate in metastatic colorectal carcinoma.
Topics: Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1975 |
Heterogeneity of human adenocarcinomas of the colon and the stomach as regards sensitivity to cytostatic drugs.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Cytarabine; Fluorouracil; Humans; Melphalan; Methotrexate; Stomach Neoplasms; Vinblastine | 1975 |
Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cisplatin; Colonic Neoplasms; DNA, Neoplasm; Doxorubicin; Drug Screening Assays, Antitumor; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Mitomycins; Peplomycin; Remission Induction; Stomach Neoplasms; Thymidine; Tritium; Tumor Cells, Cultured | 1992 |
Unexpected prolonged myelosuppression after mitomycin, mitoxantrone and methotrexate.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Mitomycins; Mitoxantrone; Thrombocytopenia; Time Factors | 1992 |
Expression and characterization of mucins associated with the resistance to methotrexate of human colonic adenocarcinoma cell line HT29.
Topics: Cell Differentiation; Colonic Neoplasms; Drug Resistance; Fluorescent Antibody Technique; Gene Expression; Glycosyltransferases; Humans; In Vitro Techniques; Methotrexate; Mucins; RNA, Messenger; RNA, Neoplasm; Sialic Acids; Tumor Cells, Cultured | 1992 |
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Methotrexate; Pteroylpolyglutamic Acids; Pyrimidines; RNA, Neoplasm; Thymidylate Synthase; Time Factors | 1992 |
In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues.
Topics: Acyltransferases; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Methotrexate; Mice; Mice, Inbred C57BL; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine | 1992 |
Azidothymidine-induced cytotoxicity and incorporation into DNA in the human colon tumor cell line HCT-8 is enhanced by methotrexate in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Line; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Thymidylate Synthase; Transplantation, Heterologous; Zidovudine | 1992 |
Effects of methotrexate-carcinoembryonic-antigen-antibody immunoconjugates on GW-39 human tumors in nude mice.
Topics: Animals; Antibodies, Monoclonal; Carcinoembryonic Antigen; Colonic Neoplasms; Dextrans; Drug Administration Schedule; Female; Humans; Immunotoxins; Injections, Intraperitoneal; Methotrexate; Mice; Neoplasm Transplantation | 1990 |
Rapid development of resistance to antifolates in vitro: possible clinical implication.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Folic Acid Antagonists; Leukemia P388; Methotrexate; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1991 |
Heterogeneity of methotrexate binding in human colon tumor cells.
Topics: Carcinoma; Colonic Neoplasms; Cytosol; Humans; Hydrogen-Ion Concentration; Methotrexate; Tetrahydrofolate Dehydrogenase; Tissue Extracts | 1991 |
Efficacy and selectivity of monoclonal-antibody-targeted drugs and free methotrexate in fluorescence-labelled mixed tumour-cell monolayer cultures and multicellular spheroids.
Topics: Antibodies, Monoclonal; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Immunotoxins; Methotrexate; Osteosarcoma; Ovarian Neoplasms; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1991 |
Increased growth adaptability to 5-fluorouracil and methotrexate of HT-29 sub-populations selected for their commitment to differentiation.
Topics: Cell Differentiation; Cell Division; Colonic Neoplasms; Drug Resistance; Fluorescent Antibody Technique; Fluorouracil; Humans; Methotrexate; Tumor Cells, Cultured | 1991 |
Selective uptake of toxic nucleoside (125IUdR) by resistant cancer.
Topics: Adenocarcinoma; Animals; Cell Line; Choriocarcinoma; Colon; Colonic Neoplasms; Cytarabine; Drug Resistance; Female; Fluorouracil; Humans; Hydroxyurea; Idoxuridine; Iodine Radioisotopes; Male; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Uterine Neoplasms | 1991 |
Fluoropyrimidine biochemical modulation in colon cancer: pharmacology relevant in both the laboratory and the clinic.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Methotrexate | 1991 |
Rapid and steady-state amino acid transport in perfused human fibroblasts and colon adenocarcinoma cells: effects of methotrexate.
Topics: Adenocarcinoma; Amino Acids; Biological Transport; Colonic Neoplasms; Fibroblasts; Humans; Methotrexate; Phenylalanine; Serine; Tumor Cells, Cultured | 1990 |
Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells.
Topics: Carcinoma; Cell Differentiation; Cell Division; Colonic Neoplasms; Fluorescent Antibody Technique; Glucose; Humans; Methotrexate; Microscopy, Electron; Mucins; Mucus; Tumor Cells, Cultured | 1990 |
Modulating fluorouracil with different drugs: the Padua experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Injections, Intraperitoneal; Injections, Intravenous; Interferon Type I; Leucovorin; Methotrexate | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1990 |
Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.
Topics: Adenocarcinoma; Biotransformation; Colonic Neoplasms; Folic Acid Antagonists; Humans; Methotrexate; Polyglutamic Acid; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1988 |
Increased growth inhibition and DNA lesions in human colon adenocarcinoma cells treated with methotrexate or 5-fluorodeoxyuridine followed by calmodulin inhibitors.
Topics: Adenocarcinoma; Bleomycin; Calmodulin; Cell Survival; Colonic Neoplasms; DNA Damage; Floxuridine; Humans; Methotrexate; Phenothiazines; Promethazine; Sulfonamides; Tumor Cells, Cultured | 1988 |
Site-specific linkage of methotrexate to monoclonal antibodies using an intermediate carrier.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Carcinoembryonic Antigen; Colonic Neoplasms; Cricetinae; Dextrans; Flow Cytometry; Methotrexate; Mice; Mice, Inbred BALB C | 1988 |
5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.
Topics: Adenocarcinoma; Colonic Neoplasms; Dipyridamole; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; Methotrexate; Nucleosides; Tumor Cells, Cultured | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
MTX-5-FU combination therapy compared to FUDR monotherapy in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1989 |
Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: implications for the mechanism of this interaction.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colony-Forming Units Assay; Drug Interactions; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Overexpression of DNA replication and repair enzymes in cisplatin-resistant human colon carcinoma HCT8 cells and circumvention by azidothymidine.
Topics: Cell Line; Cisplatin; Colonic Neoplasms; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; Drug Resistance; Etoposide; Floxuridine; Fluorouracil; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Zidovudine | 1989 |
The effects of dipyridamole and indomethacin on methotrexate cytotoxicity in LoVo human colon cancer cells.
Topics: Cell Division; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Indomethacin; Methotrexate; Tumor Cells, Cultured | 1989 |
Detection of a single base mutation in the human dihydrofolate reductase gene from a methotrexate-resistant cell line using the polymerase chain reaction.
Topics: Adenocarcinoma; Base Sequence; Cell Line; Codon; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Genes; Humans; Methotrexate; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Polymerase Chain Reaction; Restriction Mapping; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase | 1989 |
Accumulation of tetrahydrofolates in human plasma after leucovorin administration.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Injections, Intravenous; Kinetics; Leucovorin; Methotrexate; Oxidation-Reduction; Reference Values; Tetrahydrofolates | 1989 |
Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug.
Topics: Base Sequence; Binding Sites; Blotting, Northern; Blotting, Southern; Colonic Neoplasms; Deoxyribonuclease EcoRI; DNA Probes; Drug Resistance; Gene Amplification; Humans; Methotrexate; Nucleic Acid Hybridization; Polymorphism, Genetic; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1989 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate | 1986 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Hepatitis; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Transaminases | 1987 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine | 1987 |
Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
Topics: Adenocarcinoma; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methotrexate; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1987 |
ECOG phase II trials of MGBG, chlorozotocin, COM multidrug therapy in advanced measurable colorectal cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cyclophosphamide; Drug Evaluation; Humans; Methotrexate; Mitoguazone; Rectal Neoplasms; Streptozocin; Vincristine | 1988 |
Studies of methotrexate-monoclonal antibody conjugates for immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Line; Cell Transformation, Viral; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Esterification; Herpesvirus 4, Human; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms; Receptors, Cell Surface; Receptors, Transferrin; Rosette Formation | 1985 |
An aggressive, sequential combination chemotherapy regimen in the treatment of metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasm Metastasis; Rectal Neoplasms; Vincristine | 1986 |
[Subrenal capsule assay for chemosensitivity testing].
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Colony-Forming Units Assay; Cyclophosphamide; Doxorubicin; Drug Evaluation, Preclinical; Fluorouracil; Humans; Methotrexate; Mice; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tumor Stem Cell Assay | 1987 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Peptic Ulcer; Prostheses and Implants; Rectal Neoplasms | 1985 |
Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Colonic Neoplasms; Diffusion; Drug Resistance; Floxuridine; Humans; Methotrexate; Nucleosides; Sucrose; Thioinosine | 1985 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine | 1985 |
Biodistribution of a monoclonal antibody-methotrexate conjugate (791T/36-MTX) in patients with colorectal cancer.
Topics: Aged; Antibodies, Monoclonal; Colonic Neoplasms; Humans; Iodine Radioisotopes; Metabolic Clearance Rate; Methotrexate; Middle Aged; Radionuclide Imaging; Rectal Neoplasms | 1988 |
Sensitivity of newly established colorectal cell lines to cytotoxic drugs and monoclonal antibody drug conjugates.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Daunorubicin; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Methotrexate; Rectal Neoplasms; Tumor Cells, Cultured | 1987 |
Imaging of primary and metastatic colorectal carcinoma with monoclonal antibody 791T/36 and the therapeutic potential of antibody-drug conjugates.
Topics: Animals; Antibodies, Monoclonal; Colonic Neoplasms; Humans; Indium Radioisotopes; Methotrexate; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Radionuclide Imaging; Rectal Neoplasms; Thymectomy; Transplantation, Heterologous | 1987 |
Sequential methotrexate--5-FU--leucovorin (MFL) in advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1986 |
[Chemotherapy of advanced and recurrent colorectal cancer].
Topics: Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therapy; Fluorouracil; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Rectal Neoplasms | 1986 |
Leucovorine prevents methotrexate from inducing DNA lesions.
Topics: Adenocarcinoma; Cell Line; Colonic Neoplasms; DNA; DNA Repair; Humans; Hydrogen-Ion Concentration; Leucovorin; Methotrexate; Time Factors | 1986 |
Sequential methotrexate, 5-fluorouracil, and calcium leucovorin in colorectal carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1986 |
Continuous 5-fluorouracil infusion and pulse methotrexate/leucovorin for colorectal adenocarcinoma. A report of excessive toxicity.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1987 |
[Biochemical modulation with sequential methotrexate (MTX)-5-fluorouracil (5-FU) treatment].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Stomach Neoplasms | 1987 |
Sequential 5-fluorouracil and methotrexate. Negative experience in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Time Factors | 1987 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Rectal Neoplasms; Thymidine; Thymine Nucleotides | 1987 |
[Sequential methotrexate-5-fluorouracil (MTX-5-FU) treatment of patients with advanced gastric and colorectal cancer. Sequential Methotrexate-5-FU Study Group].
Topics: Adult; Aged; Colonic Neoplasms; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Stomach Neoplasms | 1987 |
Phase II trial of oral methotrexate and dipyridamole in colorectal carcinoma.
Topics: Adenocarcinoma; Administration, Oral; Aged; Colonic Neoplasms; Dipyridamole; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Kinetics; Male; Methotrexate; Middle Aged; Rectal Neoplasms | 1987 |
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Deoxyuracil Nucleotides; Drug Interactions; Female; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Male; Methotrexate; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase | 1986 |
Treatment of advanced colorectal carcinoma with actinomycin D, vincristine, methyl-CCNU, and methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colonic Neoplasms; Dactinomycin; Female; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Semustine; Vincristine | 1987 |
Management of cancer in the elderly. Implications of the aging process.
Topics: Aged; Aging; Colonic Neoplasms; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Rectal Neoplasms; Semustine; Socioeconomic Factors; Uterine Cervical Neoplasms | 1985 |
Mitomycin and methotrexate: negative experience in untreated colorectal carcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Rectal Neoplasms | 1985 |
[Coexisting malignant lymphoma and advanced adenocarcinoma of the colon--a case report].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; L-Lactate Dehydrogenase; Lymphoma; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasms, Multiple Primary; Prednisolone; Vincristine | 1985 |
Sequential therapy with methotrexate and 5-fluorouracil in the treatment of advanced colorectal carcinoma.
Topics: Adult; Aged; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Rectal Neoplasms | 1986 |
The increased cytotoxicity in colon adenocarcinoma of methotrexate-5-fluorouracil is not associated with increased induction of lesions in DNA by 5-fluorouracil.
Topics: Adenocarcinoma; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; Methotrexate | 1986 |
Methyl-CCNU and methotrexate therapy in patients with advanced colorectal cancer after failure of 5-fluorouracil chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Rectal Neoplasms; Semustine | 1986 |
Phase II study of sequential methotrexate and 5-FU combination in the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Middle Aged; Rectal Neoplasms | 1986 |
Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration.
Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Interactions; Fluorouracil; Humans; Indomethacin; Liver Neoplasms; Male; Methotrexate; Middle Aged | 1985 |
[Chemotherapy protocol for metastasizing colorectal carcinoma. Methotrexate, 5-fluorouracil and cytarabine].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cytarabine; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1985 |
Sequential methotrexate and 5-fluorouracil in the primary treatment of metastatic colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Evaluation; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Time Factors | 1985 |
A phase II study of sequential methotrexate and fluorouracil in advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Evaluation; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Rectal Neoplasms | 1985 |
Sequence-dependent synergism between dichloromethotrexate and cisplatin in a human colon carcinoma cell line.
Topics: Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Synergism; Humans; Methotrexate; Time Factors; Tumor Stem Cell Assay | 1985 |
Prolonged intra-aortic infusion therapy with anti-tumor agents for advanced cancer of the stomach, colon and rectum.
Topics: Adult; Aged; Antineoplastic Agents; Aorta; Bleomycin; Catheterization; Colonic Neoplasms; Cytarabine; Doxorubicin; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Male; Methotrexate; Middle Aged; Mitomycins; Rectal Neoplasms; Stomach Neoplasms; Time Factors | 1971 |
The treatment of hepatic metastases by long-term chemotherapeutic infusions.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Evaluation Studies as Topic; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Male; Methods; Methotrexate; Middle Aged; Neoplasm Metastasis; Rectal Neoplasms | 1970 |
[Method and results of experimental chemotherapy of a human colonic carcinoma (H.Ad.No. 1) in the cheek pouch of the golden hamster].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Aziridines; Cheek; Colonic Neoplasms; Cricetinae; Cyclophosphamide; Dactinomycin; Fluorouracil; Hydrazines; Methods; Methotrexate; Neoplasm Transplantation; Triaziquone | 1969 |
Treatment of advanced cancer with active immunization.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies; Antigen-Antibody Reactions; Breast Neoplasms; Colonic Neoplasms; gamma-Globulins; Humans; Hypersensitivity; Immunotherapy; Melanoma; Methotrexate; Neoplasms; Rabbits; Rhabdomyosarcoma; Sarcoma; Stomach Neoplasms | 1969 |
Practical aspects of investigation and treatment of colorectal cancer.
Topics: Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Function Tests; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Neoplasm Metastasis; Proctoscopy; Prognosis; Rectal Neoplasms; Sex Factors | 1972 |
[Polychemotherapy of malignant tumors and hemoblastoses].
Topics: Adenocarcinoma; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Cyclophosphamide; Dysgerminoma; Female; Fluorouracil; Hodgkin Disease; Humans; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Skin Neoplasms; Skull Neoplasms; Stomach Neoplasms; Testicular Neoplasms | 1968 |
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.
Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Glucocorticoids; Head; Head and Neck Neoplasms; Humans; Imidazoles; Lung Neoplasms; Male; Mechlorethamine; Melanoma; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Progesterone; Rectal Neoplasms; Sarcoma; Thiotepa; Triazenes | 1972 |
Results of 27 cases with hepatic metastases treated by combination chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Fluorouracil; Humans; Jaundice; Liver; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Radionuclide Imaging; Rectal Neoplasms; Vincristine | 1972 |
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given alone and combined with antimetabolites in the treatment of advanced solid tumors.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Cystadenoma; Cytarabine; Female; Humans; Leukopenia; Lung Neoplasms; Male; Methotrexate; Nausea; Neoplasm Metastasis; Neoplasms; Nitrosourea Compounds; Ovarian Neoplasms; Stomach Neoplasms; Vomiting | 1972 |
Five-drug combination chemotherapy for disseminated adenocarcinoma.
Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Ovarian Neoplasms; Parotid Neoplasms; Prednisone; Time Factors; Vincristine | 1972 |
Sequential liver scanning.
Topics: Adult; Breast Neoplasms; Chloroquine; Colonic Neoplasms; Dactinomycin; Emetine; Estrogens; Female; Fluorouracil; Gold Colloid, Radioactive; Humans; Liver Abscess, Amebic; Liver Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Radionuclide Imaging; Thiotepa | 1969 |
Chemotherapy for metastatic colorectal liver carcinoma by intra-aortic infusion.
Topics: Antineoplastic Agents; Aorta, Abdominal; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Humans; Injections, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Rectal Neoplasms; Remission, Spontaneous; Retrospective Studies; Time Factors; Vinblastine; Vincristine | 1971 |
New approaches in administration of anticancer drugs.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Cytarabine; Female; Fluorouracil; Humans; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasms; Prognosis; Time Factors | 1969 |
Infusion chemotherapy.
Topics: Antineoplastic Agents; Arm; Carcinoma, Squamous Cell; Colonic Neoplasms; Head; Head and Neck Neoplasms; Humans; Leg; Liver Neoplasms; Methods; Methotrexate; Neoplasms | 1970 |
Differential effects of anti-tumour drugs on human tumour and spleen DNA synthesis in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Culture Techniques; Disease Models, Animal; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Spleen | 1971 |
Chemotherapy for liver cancer by protracted ambulatory infusion.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Colonic Neoplasms; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Liver Neoplasms; Methotrexate; Middle Aged; Neoplasm Metastasis; Prognosis; Rectal Neoplasms | 1965 |