Page last updated: 2024-08-25

methotrexate and Clinically Isolated CNS Demyelinating Syndrome

methotrexate has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19905 (14.71)18.7374
1990's12 (35.29)18.2507
2000's8 (23.53)29.6817
2010's9 (26.47)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harrison, DD; Hsia, EC; Husni, ME; Kavanaugh, A; Kim, L; Leu, JH; Lo, KH1
Appanraj, P; Chandar, R; Cs, G; Gopakumar, KG; Nair, M; Rajeswari, B; Seetharam, S; Thankamony, P1
Dreyer, L; Locht, H; Magyari, M; Theibich, A1
Ito, H; Maeba, A; Murata, KY; Nakanishi, I; Yamanegi, M1
Beshlawi, I; Bhuyan, D; El-Banna, N; Elmanzalawy, A; Rabah, F1
Dixit, A; Gupta, M; Madkaikar, M; Patil, V1
Blevins, G; Emery, D; Gross, D; Lu, JQ; Power, C; Ringrose, J1
Boice, J; Colombel, JF; Cornillie, F; D'Haens, G; Ghosh, S; Hommes, DW; Huang, Z; Huyck, S; Lindgren, S; Panes, J; Prantera, C; Reinisch, W1
Cohen, IJ1
Bandelow, N; Hasler, P; Wiederkehr, M1
KIBLER, RF1
Abrey, LE; DeAngelis, LM; Lai, R; Rosenblum, MK1
Fleischmann, RM; Iqbal, I; Stern, RL1
Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H1
Baehring, JM; Hochberg, FH; Kleopa, KA; Stern, BV1
Harigaya, Y; Igeta, Y; Itoh, H; Nakazato, Y; Sasaki, N; Yokoo, H1
McMillan, A; O'Connor, S; Wills, AJ1
Bleyer, WA; Cohen, SR; Gangji, D; Poplack, DG; Reaman, GH1
Chrétiennot, C; Farriaux, JP; Gnansounou, M; Mazingue, F; Nelken, B; Pruvo, JP; Soto Ares, G; Vic, P1
Elkordy, M; Hulette, C; Hussein, A; Jaffe, GJ; Khawly, JA; Peters, WP; Rubin, P; Vredenburgh, JJ1
Catsman-Berrevoets, CE; Kros, JM; van Dongen, HR1
Harila-Saari, AH; Kovala, TT; Lanning, BM; Tolonen, EU; Vainionpää, LK1
Clelland, J; Hann, I; Surtees, R1
Kira, J; Murai, H1
Harila-Saari, A; Himanen, S; Lanning, M; Pääkkö, E; Pyhtinen, J; Vanionpää, L1
Dolińska, D; Honczarenko, K; Nowacki, P; Potemkowski, A1
Gütling, E; Kleihues, P; Landis, T1
Diener, HC; Ehninger, G; Majer, K; Marquardt, B; Schmidt, H; Stäb, U1
Artigas, J; Cervos-Navarro, J; Cruz-Sanchez, FF; Ferszt, R; Rossi, ML1
Gouraud, F; Jabado, N; Krief, S; Merzeau, C1
Boogerd, W; Moffie, D; Smets, LA1
Okeda, R; Shibutani, M1
Grisold, W; Lutz, D; Mamoli, B; Mokrusa, W; Weber, R1
Koestner, A; Krakowka, S; McCullough, B; Shadduck, J1

Reviews

3 review(s) available for methotrexate and Clinically Isolated CNS Demyelinating Syndrome

ArticleYear
Treatment-induced leukoencephalopathy in primary CNS lymphoma: a clinical and autopsy study.
    Neurology, 2004, Feb-10, Volume: 62, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Cranial Irradiation; Cytarabine; Dementia; Dementia, Vascular; Demyelinating Diseases; Disease Progression; Doxorubicin; Epilepsy, Complex Partial; Etoposide; Eye Neoplasms; Fatal Outcome; Female; Gait Disorders, Neurologic; Humans; Immunocompetence; Intracranial Arteriosclerosis; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Procarbazine; Radiation Injuries; Retrospective Studies; Survival Analysis; Thiotepa; Vincristine

2004
Considerations with the use of biological therapy in the treatment of rheumatoid arthritis.
    Expert opinion on drug safety, 2004, Volume: 3, Issue:5

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Clinical Trials as Topic; Combined Modality Therapy; Cytokines; Demyelinating Diseases; Disease Progression; Drug Therapy, Combination; Erythema; Heart Failure; Humans; Immunocompromised Host; Immunologic Factors; Interleukin-1; Methotrexate; Neoplasms; Opportunistic Infections; Tuberculosis; Tumor Necrosis Factor-alpha

2004
[Disseminated necrotizing leukoencephalopathy].
    Ryoikibetsu shokogun shirizu, 1999, Issue:27 Pt 2

    Topics: Antimetabolites, Antineoplastic; Demyelinating Diseases; Diagnosis, Differential; Encephalomyelitis, Acute Disseminated; Humans; Methotrexate; Prognosis; Radiotherapy

1999

Trials

2 trial(s) available for methotrexate and Clinically Isolated CNS Demyelinating Syndrome

ArticleYear
Safety and Efficacy of Intravenous Golimumab in Patients With Active Psoriatic Arthritis: Results Through Week Twenty-Four of the GO-VIBRANT Study.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Demyelinating Diseases; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Neoplasms; Opportunistic Infections; Patient Reported Outcome Measures; Treatment Outcome

2017
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:4

    Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates

1998

Other Studies

29 other study(ies) available for methotrexate and Clinically Isolated CNS Demyelinating Syndrome

ArticleYear
Paraneoplastic Demyelinating Sensorimotor Neuropathy Delaying the Diagnosis of an Underlying Acute Lymphoblastic Leukemia in a Child.
    Journal of oncology practice, 2018, Volume: 14, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Child; Daunorubicin; Demyelinating Diseases; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Paraneoplastic Syndromes, Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Spine; Tomography, X-Ray Computed; Vincristine

2018
Demyelinizing neurological disease after treatment with tumor necrosis factor alpha-inhibiting agents in a rheumatological outpatient clinic: description of six cases.
    Clinical rheumatology, 2014, Volume: 33, Issue:5

    Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cohort Studies; Demyelinating Diseases; Etanercept; Female; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Infliximab; Male; Methotrexate; Middle Aged; Nervous System Diseases; Outpatients; Receptors, Tumor Necrosis Factor; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha

2014
Methotrexate myelopathy after intrathecal chemotherapy: a case report.
    Journal of medical case reports, 2015, Jun-09, Volume: 9

    Topics: Antimetabolites, Antineoplastic; Demyelinating Diseases; Fatal Outcome; Humans; Injections, Spinal; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Spinal Cord; Spinal Cord Diseases

2015
A Demyelinating Disease; What Lies Beneath?
    Indian journal of pediatrics, 2016, Volume: 83, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Demyelinating Diseases; Diagnosis, Differential; Doxorubicin; Encephalomyelitis, Acute Disseminated; Etoposide; Humans; Hydrocortisone; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Male; Methotrexate; Prednisone; Vincristine

2016
Predominant Neurologic Manifestations Seen in a Patient With a Biallelic Perforin1 Mutation (PRF1; p.R225W).
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:2

    Topics: Adult; Brain Stem; Child, Preschool; Codon; Cyclosporine; Demyelinating Diseases; Dexamethasone; Exons; Female; Ferritins; Frontal Lobe; Humans; Immunosuppressive Agents; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Methotrexate; Movement Disorders; Muscle Weakness; Mutation, Missense; Perforin; Recurrence; Respiratory Tract Infections

2017
Multifocal inflammatory demyelination in a patient with rheumatoid arthritis and treatment complications.
    Journal of the neurological sciences, 2016, Aug-15, Volume: 367

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Demyelinating Diseases; Fatal Outcome; Female; Humans; Hydroxychloroquine; Methotrexate; Middle Aged

2016
Five-year Safety Data From ENCORE, a European Observational Safety Registry for Adults With Crohn's Disease Treated With Infliximab [Remicade®] or Conventional Therapy.
    Journal of Crohn's & colitis, 2017, Jun-01, Volume: 11, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Azathioprine; Crohn Disease; Demyelinating Diseases; Drug Substitution; Drug Therapy, Combination; Female; Gastrointestinal Agents; Hematologic Diseases; Humans; Immunosuppressive Agents; Infections; Infliximab; Infusions, Intravenous; Lymphoproliferative Disorders; Male; Mercaptopurine; Mesalamine; Methotrexate; Middle Aged; Mortality; Narcotics; Prednisone; Prospective Studies; Registries; Risk Factors; Sulfasalazine; Time Factors; Young Adult

2017
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:1

    Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
[Mononeuritis multiplex under the TNF-alpha inhibitor infliximab].
    Praxis, 2011, Feb-16, Volume: 100, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Demyelinating Diseases; Humans; Immunoglobulins, Intravenous; Infliximab; Male; Methotrexate; Spondylitis, Ankylosing; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha

2011
INTRODUCTORY REMARKS: SUPPRESSION OF DEMYELINATING DISEASE.
    Annals of the New York Academy of Sciences, 1965, Mar-31, Volume: 122

    Topics: Demyelinating Diseases; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Methylprednisolone; Pharmacology

1965
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
    Neurology, 2005, Mar-08, Volume: 64, Issue:5

    Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine

2005
Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system.
    Journal of neuro-oncology, 2006, Volume: 78, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Demyelinating Diseases; Female; Head and Neck Neoplasms; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Motor Neuron Disease; Neoplasm Recurrence, Local; Nervous System Neoplasms; Neural Conduction; Peripheral Nervous System Diseases; Scalp; Skin Neoplasms; Thiotepa; Vincristine

2006
Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.
    Acta neuropathologica, 2007, Volume: 114, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Brain Diseases; Demyelinating Diseases; Female; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Methotrexate; Phenylpropionates; Prednisolone

2007
Sub-acute demyelinating neuropathy associated with an NK/T cell lymphoma.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cyclophosphamide; Cytarabine; Demyelinating Diseases; Doxorubicin; Etoposide; Facial Paralysis; Female; Humans; Ifosfamide; Lymphoma, Extranodal NK-T-Cell; Magnetic Resonance Imaging; Methotrexate; Neurologic Examination; Omentum; Paraneoplastic Polyneuropathy; Spinal Nerve Roots; Tomography, X-Ray Computed; Treatment Outcome; Vincristine

2008
Leukoencephalopathy and elevated levels of myelin basic protein in the cerebrospinal fluid of patients with acute lymphoblastic leukemia.
    The New England journal of medicine, 1980, Jul-03, Volume: 303, Issue:1

    Topics: Adolescent; Adult; Brain; Brain Diseases; Child; Child, Preschool; Demyelinating Diseases; Humans; Leukemia, Lymphoid; Methotrexate; Myelin Basic Protein

1980
[Radiological case of the month. Leukoencephalopathy caused by methotrexate in a child treated for acute lymphoblastic leukemia].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Demyelinating Diseases; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1996
Ocular toxicity following high dose chemotherapy and autologous transplant.
    Bone marrow transplantation, 1996, Volume: 18, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Demyelinating Diseases; Diagnosis, Differential; Doxorubicin; Fatal Outcome; Female; Fluorouracil; Hematopoietic Stem Cell Transplantation; Humans; Ischemia; Mastectomy, Modified Radical; Methotrexate; Middle Aged; Optic Nerve; Paraneoplastic Syndromes; Respiratory Insufficiency; Scotoma; Transplantation Conditioning; Visual Fields

1996
Development of the anterior cingulate syndrome in a child due to delayed necrotising methotrexate leukoencephalopathy.
    Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:3

    Topics: Akinetic Mutism; Brain Diseases; Child; Cranial Irradiation; Demyelinating Diseases; Fatal Outcome; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1997
Nerve lesions after therapy for childhood acute lymphoblastic leukemia.
    Cancer, 1998, Jan-01, Volume: 82, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Axons; Brachial Plexus; Case-Control Studies; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Demyelinating Diseases; Evoked Potentials, Somatosensory; Female; Humans; Male; Median Nerve; Methotrexate; Motor Skills; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Reflex, Stretch; Risk Factors; Spinal Cord; Spinal Cord Diseases; Tibial Nerve; Vincristine

1998
White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings.
    Medical and pediatric oncology, 2000, Volume: 35, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Brain Injuries; Child; Child, Preschool; Cytarabine; Demyelinating Diseases; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy, Adjuvant; Statistics, Nonparametric

2000
Impairment of vertebral canal nervous structures after intrathecal prophylaxis in non-Hodgkin's lymphomas.
    Neuropatologia polska, 1992, Volume: 30, Issue:3-4

    Topics: Adolescent; Adult; Aged; Cauda Equina; Demyelinating Diseases; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Myelin Sheath; Spinal Cord; Spinal Cord Neoplasms; Spinal Nerve Roots

1992
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings.
    Journal of neurology, 1992, Volume: 239, Issue:3

    Topics: Adult; Afferent Pathways; Akinetic Mutism; Alpha Rhythm; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cranial Fossa, Posterior; Cranial Irradiation; Cyclophosphamide; Demyelinating Diseases; Doxorubicin; Electroencephalography; Evoked Potentials, Somatosensory; Female; Fluorouracil; Humans; Mastectomy; Methotrexate; Necrosis; Stereotyped Behavior

1992
[Neurologic complications after bone marrow transplantation].
    Der Nervenarzt, 1991, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Brain; Central Nervous System Diseases; Child; Demyelinating Diseases; Electroencephalography; Evoked Potentials, Visual; Female; Humans; Leukemia; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Middle Aged; Neurologic Examination; Postoperative Complications; Radiation Injuries; Spinal Cord; Tomography, X-Ray Computed; Whole-Body Irradiation

1991
Brain lesions following combined treatment with methotrexate and craniospinal irradiation.
    Journal of neuro-oncology, 1991, Volume: 10, Issue:2

    Topics: Adult; Aged; Brain Diseases; Brain Edema; Breast Neoplasms; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Demyelinating Diseases; Diagnosis, Differential; Female; Gastrointestinal Diseases; Humans; Injections, Intravenous; Injections, Spinal; Lymphoma; Male; Meningeal Neoplasms; Mental Disorders; Methotrexate; Middle Aged; Necrosis

1991
[Iconographic rubric. A case of leukoencephalopathy following intraventricular injection of methotrexate].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:4

    Topics: Child, Preschool; Demyelinating Diseases; Female; Humans; Injections, Intraventricular; Methotrexate; Tomography, X-Ray Computed

1991
Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis.
    Cancer, 1990, Feb-01, Volume: 65, Issue:3

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Blindness; Breast Neoplasms; Coma; Cytarabine; Demyelinating Diseases; Female; Humans; Injections, Intraventricular; Meningeal Neoplasms; Methotrexate

1990
Experimental study on subacute neurotoxicity of methotrexate in cats.
    Acta neuropathologica, 1989, Volume: 78, Issue:3

    Topics: Animals; Cats; Cerebrospinal Fluid; Demyelinating Diseases; Disease Models, Animal; Drug Synergism; Female; Male; Methotrexate; Necrosis; Neurotoxins; Risk Factors

1989
[Acute myelomonocytic and monoblastic leukemia with polyradicular symptoms].
    Wiener klinische Wochenschrift, 1985, Aug-30, Volume: 97, Issue:16

    Topics: Abducens Nerve; Adult; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebral Hemorrhage; Cerebrospinal Fluid; Cranial Nerve Diseases; Cytarabine; Danazol; Demyelinating Diseases; Facial Paralysis; Female; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Meningism; Methotrexate; Middle Aged; Spinal Nerve Roots; Tamoxifen

1985
Demyelinating activity of canine distemper virus isolates in gnotobiotic dogs.
    The Journal of infectious diseases, 1974, Volume: 130, Issue:4

    Topics: Animals; Antibodies, Viral; Brain; Cerebellum; Demyelinating Diseases; Distemper; Distemper Virus, Canine; Dogs; Encephalitis; Germ-Free Life; Immunosuppression Therapy; Leukocyte Count; Lymphopenia; Methotrexate; Neutralization Tests; Virulence

1974