Page last updated: 2024-08-25

methotrexate and Chromosomal Fragility

methotrexate has been researched along with Chromosomal Fragility in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (71.43)	18.7374
1990's	6 (28.57)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Daniel, A; Ekblom, L; Phillips, S	1
Anness, V; Chitham, RG; Haslam, JS; Taylor, JW	1
Nielsen, KB; Tommerup, N	1
Barbi, G; Steinbach, P; Vogel, W	1
Natarajan, AT; Slijepcevic, P	1
Hittelman, WN; Jiang, LX; Kuo, MT; Vyas, RC	1
Buttin, G; Coquelle, A; Debatisse, M; Pipiras, E; Toledo, F	1
Iakovleva, TK; Moiseenko, VM; Monakhov, AS	1
Barrios, L; Egozcue, J; Fuster, C; Miró, R	1
Mariani, T; Piras, A; Rainaldi, G; Simi, S; Vatteroni, L	1
De Giuli Morghen, C; Larizza, L; Riva, P	1
Barrios, L; Egozcue, J; Fuster, C; Miró, R; Templado, C	2
Hustinx, TW; Scheres, JM; Smeets, DF	1
Götz, J; Krüger, G; Pelz, L; Witt, G	1
Caporossi, D; Dallapiccola, B; Nicoletti, B; Porfirio, B; Tedeschi, B; Vernole, P	1
Caporossi, D; Nicoletti, B; Tedeschi, B; Vernole, P	1
Barbi, G; Djalali, M; Steinbach, P	1
Hecht, BK; Hecht, F; Morgan, R; Morgan, SS	1
Schimke, RT	1
Ledbetter, DH; Nussbaum, RL	1

Reviews

2 review(s) available for methotrexate and Chromosomal Fragility

Article	Year
Methotrexate resistance and gene amplification. Mechanisms and implications. Cancer, 1986, May-15, Volume: 57, Issue:10 Topics: Animals; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosome Fragility; DNA Replication; Drug Resistance; Gene Amplification; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase	1986
Fragile X syndrome: a unique mutation in man. Annual review of genetics, 1986, Volume: 20 Topics: Caffeine; Chromosome Fragility; Female; Fragile X Syndrome; Genetic Counseling; Genetic Linkage; Genetic Markers; Heterozygote; Humans; Hybrid Cells; Intellectual Disability; Male; Methotrexate; Models, Genetic; Pedigree; Phenotype; Sex Chromosome Aberrations; Thymidine	1986

Other Studies

19 other study(ies) available for methotrexate and Chromosomal Fragility

Article	Year
Fragile X expression suppressed in either FUdR or methotrexate treated fibroblasts by pretreatment with 5-azacytidine. American journal of medical genetics, 1984, Volume: 17, Issue:1 Topics: Azacitidine; Chromosome Fragility; Drug Interactions; Female; Fibroblasts; Floxuridine; Gene Expression Regulation; Humans; Male; Methotrexate; X Chromosome	1984
Selection and use of a method for the culture of blood leucocytes to reveal the fra(x) site. Journal of clinical pathology, 1984, Volume: 37, Issue:4 Topics: Adult; Cells, Cultured; Child; Chromosome Fragility; Culture Media; Cytological Techniques; Female; Floxuridine; Humans; Hydrogen-Ion Concentration; Leukocytes; Male; Mental Disorders; Methotrexate; X Chromosome	1984
Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression. Human genetics, 1984, Volume: 66, Issue:2-3 Topics: Adolescent; Adult; Bromodeoxyuridine; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Female; Fibroblasts; Floxuridine; Folic Acid; Gene Expression Regulation; Genetic Markers; Humans; Infant; Intellectual Disability; Lymphocytes; Male; Methotrexate; Middle Aged; X Chromosome	1984
Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites. Human genetics, 1984, Volume: 68, Issue:4 Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Folic Acid Deficiency; Humans; Karyotyping; Lymphocytes; Methotrexate	1984
Fragile site at Xq21 in Chinese hamster and its implications for the in vitro chromosomal aberration test. Mutagenesis, 1995, Volume: 10, Issue:4 Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Line; CHO Cells; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Cricetinae; Cricetulus; Fibroblasts; Folic Acid Antagonists; Methotrexate; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; X Chromosome	1995
Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Molecular and cellular biology, 1994, Volume: 14, Issue:8 Topics: Animals; Aphidicolin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; CHO Cells; Chromosome Fragile Sites; Chromosome Fragility; Cricetinae; DNA Damage; Drug Resistance; Gene Amplification; In Situ Hybridization, Fluorescence; Membrane Glycoproteins; Methotrexate	1994
Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell, 1997, Apr-18, Volume: 89, Issue:2 Topics: Adenosine Deaminase; AMP Deaminase; Animals; Cell Line; Chromosome Fragile Sites; Chromosome Fragility; Coformycin; Cricetinae; Cricetulus; Dactinomycin; DNA Damage; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Gene Amplification; Genes, MDR; Methotrexate; Mutagens; Tetrahydrofolate Dehydrogenase; Vinblastine	1997
[Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy]. Tsitologiia, 1992, Volume: 34, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Combined Modality Therapy; Female; Fluorouracil; Humans; Lymphocytes; Methotrexate; Middle Aged; Ring Chromosomes; Tamoxifen; Time Factors	1992
Induction of premature centromere division affecting all chromosomes under culture conditions of fragile site expression. Cancer genetics and cytogenetics, 1992, Volume: 58, Issue:2 Topics: Cells, Cultured; Centromere; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Humans; Karyotyping; Methotrexate; Reference Values; Thymidine	1992
Folate-sensitive fragile sites in Chinese hamster cell lines. Cancer genetics and cytogenetics, 1990, Volume: 46, Issue:2 Topics: Animals; Cell Line; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Cricetinae; Cricetulus; Folic Acid; Karyotyping; Methotrexate	1990
Involvement of unstable chromosomal regions containing C-heterochromatin and fragile sites in the integration of amplified dhfr domains. Somatic cell and molecular genetics, 1989, Volume: 15, Issue:5 Topics: Animals; Blotting, Southern; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes; Drug Resistance; Gene Amplification; Heterochromatin; Methotrexate; Mice; Recombination, Genetic; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1989
Expression of folate-sensitive fragile sites in lymphocyte chromosomes. Human genetics, 1989, Volume: 81, Issue:3 Topics: Adult; Cells, Cultured; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Female; Folic Acid; Humans; Lymphocytes; Male; Methotrexate; X Chromosome	1989
The most common fragile site in man is 3p14. Human genetics, 1986, Volume: 72, Issue:3 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 1-3; Female; Floxuridine; Humans; Infant; Karyotyping; Male; Methotrexate; Middle Aged; Pedigree	1986
Increased methotrexate-induced chromosome breakage in patients with free trisomy 21 and their parents. Human genetics, 1988, Volume: 81, Issue:1 Topics: Adult; Cells, Cultured; Child, Preschool; Chromosome Fragility; Chromosomes, Human, Pair 21; Down Syndrome; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Parents; Polymorphism, Genetic	1988
Common fragile sites: their prevalence in subjects with constitutional and acquired chromosomal instability. American journal of medical genetics, 1987, Volume: 27, Issue:2 Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aphidicolin; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Fanconi Anemia; Female; Heterozygote; Humans; Italy; Lymphocytes; Male; Methotrexate; Middle Aged; Ovarian Neoplasms	1987
Common fragile sites and human cancer. A study on lymphocytes from neuroblastoma patients. Cancer genetics and cytogenetics, 1988, Volume: 36, Issue:1 Topics: Adolescent; Adult; Aphidicolin; Bone Marrow; Cells, Cultured; Child; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, Pair 1; Diterpenes; Female; Humans; Lymphocytes; Male; Methotrexate; Neuroblastoma	1988
Folic acid sensitive fragile sites are not limited to the human karyotype. Demonstration of nonrandom gaps and breaks in the Persian vole Ellobius lutescens Th. inducible by methotrexate, fluorodeoxyuridine, and aphidicolin. Human genetics, 1985, Volume: 70, Issue:2 Topics: Animals; Aphidicolin; Arvicolinae; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Female; Floxuridine; Folic Acid; Humans; Karyotyping; Male; Methotrexate; Species Specificity	1985
Fragile sites at 4q23 and 7q11.23 unique to bone marrow cells. Cancer genetics and cytogenetics, 1988, Volume: 31, Issue:1 Topics: Adult; Aged; Bone Marrow; Cells, Cultured; Child; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 7; Female; Genetic Markers; Humans; Karyotyping; Male; Methotrexate; Middle Aged	1988
Can sister chromatid intercrossings be considered as prelesions? Human genetics, 1988, Volume: 79, Issue:2 Topics: Cells, Cultured; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Folic Acid; Humans; Karyotyping; Lymphocytes; Methotrexate; Sister Chromatid Exchange	1988