methotrexate has been researched along with Chemical and Drug Induced Liver Injury in 496 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 155 (31.25) | 18.7374 |
| 1990's | 55 (11.09) | 18.2507 |
| 2000's | 54 (10.89) | 29.6817 |
| 2010's | 150 (30.24) | 24.3611 |
| 2020's | 82 (16.53) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Clary, DD; Fanciullo, J; Kiani, R; Reid, AT | 1 |
| El-Gerbed, MSA; Ghoneum, M | 1 |
| Baecklund, E; Cavalli, M; Eriksson, N; Hallberg, P; Kohnke, H; Sundbaum, JK; Wadelius, C; Wadelius, M; Wallenberg, M | 1 |
| Aşcı, H; Doğan, HK; İlhan, İ; Mustafaoğlu, A; Özgöçmen, M; Pekgöz, Ş | 1 |
| An, R; Hao, J; Xue, Y; Yu, H; Zhang, M; Zhang, T; Zhou, W | 1 |
| Asci, H; Ciris, M; Erzurumlu, Y; Hasseyid, N; Ilhan, I; Pekgöz, S; Savran, M | 1 |
| Choi, KH; Gwak, HS; Han, JM; Lee, HH | 1 |
| Alfwuaires, MA | 1 |
| Bhattacharya, A; Jaimini, A; Kumar, A; Mehra, L; Mittal, G; Rawat, H | 1 |
| Azadnasab, R; Kalantar, H; Kalantari, H; Khodayar, MJ; Khorsandi, L | 1 |
| Abdel-Raheem, IT; Ghoneim, AI; Khatab, LA | 1 |
| Frankowski, M; Gomułkiewicz, M; Korman, L; Skoczyńska, M; Starba, A; Świerkot, J | 1 |
| Abe, K; Furukawa, T; Hashimoto, H; Ishizu, T; Iwata, S; Kawano, Y; Kobayashi, E; Maeda-Minami, A; Mano, Y; Miyazaki, S; Shimoi, T; Yamaguchi, M | 1 |
| Abdel-Kawi, SH; Abdel-Reheim, ES; Abdul-Hamid, M; Allam, A; Alwaele, MA; Hegazy, W; Othman, SI | 1 |
| El-Nahass, EE; Elwan, M; Kandeil, M | 1 |
| Sheikha, MA; Soheir, NA; SyragEldin, FM | 1 |
| Al-Kuraishy, HM; Alorabi, M; Alotaibi, SS; Batiha, GE; Conte-Junior, CA; El-Sherbeni, SA; Lawal, B; Mohammed, AIA; Mohammed, DS; Mostafa-Hedeab, G; Nasreldin, N; Negm, WA | 1 |
| Gürel, E; Gürler, M; Özerol, BG; Selçuk, EB; Tanbek, K; Taşlıdere, E; Yağın, FH; Yıldız, A | 1 |
| Chasman, DI; Cui, J; Karlson, EW; Raychaudhuri, S; Ridker, PM; Solomon, DH; Xu, C | 1 |
| Chatterjee, M; Pradhan, A; Sengupta, R; Sengupta, S | 1 |
| Awad, EM; El-Sheikh, AAK; El-Tahawy, NFG; Matouk, AI; Waz, S | 1 |
| Ding, T; Li, Z; Qiu, X; Sun, K; Tao, H; Wu, Z; Zhong, M | 1 |
| Abukhalil, MH; Al-Khawalde, AAA; Aladaileh, SH; Alanezi, AA; Alaryani, FS; Alasmari, F; Aldal'in, HK; Alfwuaires, MA; Algefare, AI; Althunibat, OY; Jghef, MM; Karimulla, S | 1 |
| El-Kashef, DH; Sewilam, HM | 1 |
| Abedi, SM; Mehraban, N; Mohammadinia, S; Noaparast, Z; Shahani, S; Talebpour Amiri, F | 1 |
| Gaiser, C; Hämmerli, C; Messner, CJ; Schmidt, S; Suter-Dick, L | 1 |
| Aubin, F; Avouac, J; Di Martino, V; Lioté, F; Thévenot, T; Verhoeven, DW; Verhoeven, F; Vuitton, L; Wendling, D | 1 |
| Allaart, CF; Böhringer, S; den Broeder, AA; Dolžan, V; Eektimmerman, F; Guchelaar, HJ; Hazes, JMW; Kurreeman, FS; Nair, N; Nurmohamed, MT; Pawlik, A; Swen, JJ; Verstappen, SMM | 1 |
| Ayna, A; Caglayan, C; Darendelioğlu, E; Gür, C; Kandemir, FM; Kızıl, HE; Küçükler, S | 1 |
| Chen, YC; Hsiao, CC; Hsieh, HY; Huang, LT; Huang, YC; Lo, WS; Sheen, JM; Wang, SC | 1 |
| Ding, T; Li, Z; Qiu, X; Wu, Z; Zhong, M | 1 |
| Abd Hasan, RR; Aggad, SS; Al-Gareeb, AIA; Al-Kuraishy, HM; Aljohani, ASM; Batiha, GE; El-Ashmawy, IM; Elekhnawy, E; Mostafa, SA; Negm, WA | 1 |
| Chang, YL; Chen, WM; Chou, YC; Huang, KW; Hung, GY; Lee, HC; Wang, SF; Wu, PK | 1 |
| Abdelzaher, WY; El-Hussieny, M; Refaie, MMM; Shehata, S; Welson, NN | 1 |
| Cheng, Z; Wang, S; Xie, F; Yang, M; Yin, Q | 1 |
| Abbas, SS; Abdel-Latif, GA; Elmongy, NF; Radwan, SM; Wasfey, EF | 1 |
| Crasta, R; Javed, F; Shakhashiro, M | 1 |
| Bouma, G; Bulatović Ćalasan, M; de Boer, NKH; de Jonge, R; Fidder, HH; Koehestanie, P; Kuyvenhoven, JP; Lutgens, MWMD; Mahmmod, N; Mares, WGN; Montazeri, NSM; Nissen, LHC; Oldenburg, B; Rietdijk, ST; Struys, EA; Sundaresan, J; van Asseldonk, DP; van de Meeberg, MM | 1 |
| Demirbolat, GM; Ergin, AD; Oltulu, Ç; Türker, NP | 1 |
| Balforoush, M; Hoshyar, R; Hosseini, M; Sebzari, A; Valavi, M | 1 |
| Hatachi, S; Kamitsuji, S; Kawate, M; Kobayashi, M; Kumagai, S; Misaki, K; Morinobu, A; Nakazawa, T; Nishida, M; Nishimura, K; Nobuhara, Y; Onishi, A; Saito, T; Takahashi, M; Tsuji, G; Uemura, Y; Yoshida, Y | 1 |
| Al-Abadi, E; Brown, RM; Gupte, GL; Kelgeri, C; Ramakrishna, SH | 1 |
| Hiramatsu, SI; Ikemura, K; Iwamoto, T; Katayama, N; Nakatani, Y; Okuda, M; Shinogi, Y; Tawara, I | 1 |
| Chen, XY; Guo, ZT; Hou, XY; Liu, L; Pang, XY; Zhou, L | 1 |
| Cai, H; Cao, X; Chen, M; Duan, M; Feng, J; Li, J; Wang, W; Yang, C; Zhang, L; Zhang, W; Zhang, Y; Zhou, D; Zhu, T; Zhuang, J | 1 |
| Badparva, R; Goudarzi, M; Khorsandi, L; Malayeri, A; Mombeini, MA | 1 |
| Girndt, M; Lübbert, C; Pliquett, RU; Schäfer, C | 1 |
| Helal, MG; Said, E | 1 |
| Abdelazem, AZ; Abdelaziz, RM; Attia, YA; Hashem, KS | 1 |
| Chen, C; Cheng, SB; Liu, YH; Wu, SL; Zhai, XJ | 1 |
| Abd El-Twab, SM; Bin-Jumah, MN; Germoush, MO; Hozayen, WG; Hussein, OE; Mahmoud, AM | 1 |
| Bai, J; Fan, X; Hu, J; Hu, M; Li, Y; Sun, Y; Wang, B; Xu, Y; Zhao, S | 1 |
| Bafna, V; Bartakke, S; Pawar, A; Sajith, M | 1 |
| Abdel-Moneim, AM; Alfwuaires, M; Algefare, AI; Elmenshawy, OM; Elsawy, H; Khalil, M; Sedky, A | 1 |
| Aldhahrani, A; Alkhedaide, A; Althobaiti, F; Mohamed, WA; Nassan, MA; Soliman, MM | 1 |
| Fischer, EA; Hetland, ML; Krabbe, S | 1 |
| Koch, K | 1 |
| Chauhan, P; Kumar, U; Mayachari, A; Sangli, G; Sharma, H; Singh, S | 1 |
| Abdel-Wahab, BA; Ali, FEM; Alkahtani, SA; Alshabi, AM; Hassanein, EHM; Mahnashi, MH | 1 |
| Bharucha, KN; Brunner, HI; Burgos-Vargas, R; Cuttica, R; de Benedetti, F; Douglass, W; Duarte, C; Espada, G; Job-Deslandre, C; Joos, R; Keltsev, V; Kimura, Y; Lovell, DJ; Martini, A; Penades, IC; Ruperto, N; Silverman, ED; Wells, C; Wimalasundera, S; Xavier, RM; Zavaler, MF; Zuber, Z | 1 |
| Akin, AT; Karabulut, D; Kaymak, E; Kuloglu, N; Ozturk, E; Yakan, B | 1 |
| Goudarzi, M; Kalantar, H; Kalantar, M; Karamallah, MH; Sadeghi, E | 1 |
| Chang, X; Guo, Y; Hu, R; Hui, W; Su, L; Sun, W; Zhang, Y; Zhao, H | 1 |
| Elhamshary, A; Haroon, M; Yassin, NA | 1 |
| Beriwal, A; Khera, S; Ramachandran, S; Ranjan, R | 1 |
| Bakr, RO; Eldahshan, OA; Elissawy, AE; Fayez, AM; Shahat, EA | 1 |
| Alarifi, S; Albasher, G; Alfarraj, S; Alkhatani, S; Almeer, R; Alqahtani, WS; Dar, AA; Fehaid, A; Moneim, AA | 1 |
| Egeberg, A; Gelfand, JM; Ogdie, A; Shin, DB; Syed, MN; Wan, J; Zhang, H | 1 |
| Andersson, NW; Simonsen, AB; Thomsen, SF; Zachariae, C | 1 |
| Sakharova, TS; Vietrova, KV; Zupanets, IA | 1 |
| Azzam, A; Jiyad, Z; O'Beirne, J | 1 |
| Akyol, Y; Erdemli-Kose, SB; Garli, S; Ozmen, O; Sahindokuyucu-Kocasari, F | 1 |
| Abdullah, ST; Ahmed, I; Bag, S; Bhatt, S; Dhiman, S; Dogra, A; Gupta, D; Kumar, A; Nandi, U; Nehra, E; Sangwan, PL; Singh, G | 1 |
| Elston, D | 1 |
| Liu, MQ; Liu, S; Liu, YL; Qin, LP; Zhang, Q; Zhang, QY; Zhu, LL | 1 |
| Alves, AM; Bettanin, BF; Gehringer, M; Goettert, MI; Laufer, S; Majolo, F; Rocha, CM | 1 |
| Abo-Youssef, AM; Hassan, MIA; Hemeida, RAM; Osman, AT; Sharkawi, SMZ | 1 |
| Aggarwal, A; Dhawan, V; Dhir, V; Gupta, R; Jain, S; Khullar, A; Leishangthem, B; Maurya, S; Naidu, S; Sharma, A; Sharma, SK | 1 |
| Choi, SR; Lee, EB; Park, JK; Park, JW | 1 |
| Ezhilarasan, D | 1 |
| Aylı, M; Caliskan, E; Coban, SN; Esme, P; Ugur, B | 1 |
| Cui, Y; Lin, S; Mei, S; Ren, X; Yu, K; Zeng, C; Zhao, Q; Zhao, Z | 1 |
| Demir, B; Demir, E; Sütcüoğlu, O; Ünsal, O; Yazıcı, O | 1 |
| Abo-Haded, HM; Al-Ahmadi, O; Al-Johani, Z; El-Agamy, DS; Elkablawy, MA | 1 |
| Costello, R; Dixon, WG; Humphreys, JH; Lunt, M; Verstappen, SMM; Warner, A | 1 |
| Nikamo, P; Rosenberg, P; Ståhle, M; Talme, T | 1 |
| Fikry, EM; Gad, AM; Hassan, WA | 1 |
| Hozayen, WG; Mahmoud, AM; Ramadan, SM | 1 |
| Efe, C; Ozaslan, E; Purnak, T | 1 |
| Alazawi, W; Cho, W; Shetty, A; Syn, WK | 1 |
| Cacciavillano, W; Rose, A; Scopinaro, M; Villegas Rubio, JA; Zubizarreta, P | 1 |
| Abid, S; Achour, A; Amara, I; Azzebi, A; Bacha, H; Bousabbeh, M; Guedri, Y; Rjiba-Touati, K; Salem, IB | 1 |
| Dolatshahi, M; Esmaeilizadeh, M; Goudarzi, M; Hosseinzadeh, A; Khadem Haghighian, H; Mehrzadi, S; Nesari, A; Safaei, F | 1 |
| Esmaeilizadeh, M; Fatemi, I; Ghaznavi, H; Goudarzi, M; Kalantar, H; Mehrzadi, S | 1 |
| Hakamata, J; Hashiguchi, M; Kaneko, Y; Maruyama, J; Mochizuki, M; Shimizu, M; Takeuchi, T; Yamaoka, K | 1 |
| El-Sayed, YS; Khafaga, AF | 1 |
| Berti, E; Damiani, G; Fiore, M; Leone, S; Maraolo, AE | 1 |
| Bakhshayesh, M; Goudarzi, M; Kalantari, H; Malayeri, AR; Mehrabani, M; Mehrzadi, S | 1 |
| Chatterjee, M; Chatterjee, U; Chattopadhyay, S; De, S; Kundu, S | 1 |
| Arab, HH; Maghrabi, IA; Salama, SA | 1 |
| Epete, MA; Famurewa, AC; Folawiyo, AM; Igwe, EC; Maduagwuna, EK; Okike, PI | 1 |
| Bordbar, M; Fattahi, M; Haghpanah, S; Honar, N; Shakibazad, N | 1 |
| Chang, SN; Chen, DY; Chen, YM; Lin, CH; Tang, KT | 1 |
| Bielen, L; Boban, A; Božina, N; Ćurčić, E; Kralj, I; Vodanović, M | 1 |
| Lund, M; Melbye, M; Pasternak, B; Svanström, H | 1 |
| Li, F; Li, H; Li, X; Luo, S; Ran, Y; Wang, M; Wang, Y; Xie, X; Zhao, Z; Zheng, M | 1 |
| Carruthers, MN; Wade, SD; Weinblatt, ME; Yoshida, EM | 1 |
| Arima, N; Fujiyama, S; Ito, M; Kamo, Y; Mori, S; Ueki, Y | 1 |
| Chonprasertsuk, S; Lertnawapan, R; Siramolpiwat, S | 1 |
| Bunjevački, V; Damjanov, N; Damnjanović, T; Jekić, B; Krajinović, M; Maksimović, N; Milić, V; Novaković, I; Popović, B; Vejnović, D | 1 |
| Akatli, AN; Huz, M; Ozhan, O; Pamukcu, E; Parlakpinar, H; Samdanci, ET; Tanbek, K | 1 |
| Abyaz, MR; Asadmasjedi, N; Kalantari, H; Mahdavinia, M; Mohammadtaghvaei, N | 1 |
| Bakr, RO; El-Fishawy, AM; Fayed, MAA; Fayez, AM; Gabr, SK | 1 |
| Abril-Molina, A; Alés-Palmer, M; Gómez-Luque, JM; Muñoz de Rueda, P; Ocete-Hita, E; Urrutia-Maldonado, E | 1 |
| Chen, XM; Huang, QC; Huang, RY; Li, ZG; Liu, L; Pan, HD; Qiu, P; Wu, JQ; Xiao, Y; Xie, ZX; Zhou, H; Zhou, YY | 1 |
| Pivovarov, K; Zipursky, JS | 1 |
| Baecklund, E; Eriksson, N; Hallberg, P; Karlsson Sundbaum, J; Lehto, N; Wadelius, M | 1 |
| Abd El-Aziz, GS; Abuzinadah, OAH; Alrafiah, AR; Alturkistani, HA; Kelany, AM | 1 |
| Corfield, G; Fung, P; Heneghan, D; Kitchen, J; Malley, T | 1 |
| Kitagawa, I; Kudo, M; Kumagae, T; Ono, R; Teshima, S; Uojima, H; Yoshizawa, M | 1 |
| Abdelaziz, AI; Azab, SS; Fawzy, HM; Gad, AM; Mantawy, EM | 1 |
| Akcit, F; Aksoy, NH; Dalaklioglu, S; Genc, GE; Gumuslu, S | 1 |
| Aplenc, R; Chiusolo, P; Coenen, MJ; De Mattei, M; Gemmati, D; Hagleitner, MM; Hoogerbrugge, PM; Krajinovic, M; Ongaro, A; Patiño-Garcia, A; te Loo, DM; Vermeulen, SH | 1 |
| de Jong, EM; Kooijmans-Otero, M; Laarakkers, CM; Masereeuw, R; Russel, FG; van Swelm, RP | 1 |
| Adachi, S; Heike, T; Kubota, M; Nakata, R; Shima, M; Takeshita, Y; Watanabe, K | 1 |
| Ali, N; Hasan, SK; Nafees, S; Rashid, S; Sultana, S | 1 |
| Pais, R; Ratziu, V; Rusu, E | 1 |
| Beyene, J; Church, PC; Feldman, BM; Griffiths, AM; Kamath, BM; Shah, PS; Valentino, PL | 1 |
| Annamalai, AR; Banji, D; Banji, OJ; Chilipi, KK; Kalpana, CH; Kranthi Kumar, CH; Soumya, N | 1 |
| Lee, SK; Lee, SW; Park, HJ; Park, MC; Park, YB | 1 |
| Bernhardt, MB; Brackett, J; Leung, DH; Schafer, ES | 1 |
| Boscardin, WJ; Daikh, DI; Miao, Y; Schmajuk, G; Steinman, MA; Yazdany, J | 1 |
| Çalık, A; Çeşmecioğlu, E; Çobanoğlu, Ü; Kalaycı, O; Topaloğlu, S; Uzun, Y | 1 |
| Dalia, S; Forsyth, P; Jaglal, M; Price, S; Sokol, L | 1 |
| Barker, JN; Cross, R; Martyn-Simmons, CL; Rosenberg, WM; Smith, CH; Wong, T | 1 |
| Collins, P; Higgins, E; Kirby, B; Lally, A; Lynch, M; McCormick, PA; Nolan, N; Omar, H; Rogers, S; Vellinga, A | 1 |
| Bak Mohammad Zadeh, S; Dastgiri, S; Gader, S; Ghasemi, A; Hajialiloo, M; Khabbazi, A; Kolahi, S; Nazeri, L; Nazeri, M; Poormohammad, A; Sheikholeslami Salmasi, A | 1 |
| Strober, BE | 1 |
| Benton, CB; Borthakur, G; Dara, S; Franklin, AR; Garcia-Manero, G; Jabbour, E; Kantarjian, H; Kwari, M; O'Brien, S; Pierce, SR; Ravandi, F; Rytting, M; Thomas, DA; Yang, H | 1 |
| Anumol, T; Canet, MJ; Cherrington, NJ; Clarke, JD; Goedken, MJ; Hardwick, RN; Lake, AD; Merrell, MD; Snyder, SA; Street, SM | 1 |
| Davis, K; Fabian, E; Greenhaw, J; Groeters, S; Herold, M; Kamp, H; Looser, R; Marxfeld, H; Mattes, W; Mellert, W; Moeller, N; Montoya-Parra, G; Prokoudine, A; Strauss, V; van Ravenzwaay, B; Walk, T | 1 |
| Akbulut, S; Dogan, Z; Elbe, H; Erdemli, E; Eris, C; Otan, E; Toprak, G; Turkoz, Y | 1 |
| Björnsson, ES; Einarsdottir, R; Gröndal, G; Gudbjörnsson, B; Gunnarsson, BI; Jonasson, JG; Ludviksson, BR; Olafsson, S | 1 |
| Bath, RK; Brar, NK; Forouhar, FA; Wu, GY | 1 |
| Fisher, SE; Rabinowitz, SS; Schwarz, SM; Vo, HD; Xu, J | 1 |
| Cherrington, NJ; Coen, M; Goedken, MJ; Hardwick, RN; Holmes, E; Jin, Z; Kyriakides, M | 1 |
| Coenen, MJ; Hagleitner, MM; te Loo, DM | 1 |
| Braggs, NS; Cagan, A; Denny, JC; Dligach, D; Gainer, V; Karlson, EW; Lin, C; Miller, TA; Mo, H; Ramirez, MP; Savova, GK | 1 |
| Fujimoto, J; Fujita, N; Fukano, R; Gosho, M; Horibe, K; Inada, H; Kobayashi, R; Koh, K; Mitsui, T; Mori, T; Nakazawa, A; Saito, A; Sunami, S; Takimoto, T; Tanaka, F; Tsurusawa, M | 1 |
| Charro, M; Domènech, E; García-López, S; Gisbert, JP; Gomollón, F; Muñoz, F; Rubio, S | 1 |
| Ali, EA; Bilasy, SE; Essawy, SS; Mandour, MF; Zaitone, SA | 1 |
| Carlsen, N; Christensen, IJ; Dalhoff, K; Gréen, H; Gregers, J; Lausen, B; Peterson, C; Rosthoej, S; Schmiegelow, K; Schroeder, H | 1 |
| Abe, S; Harada, M; Hayashi, T; Hiura, M; Miyagawa, K; Noguchi, H; Oe, S; Shibata, M | 1 |
| Hagiwara, H; Nakano, S; Ogawa, Y; Tohkin, M | 1 |
| AbdElaal, AM; Elfaragy, MS; Elzamarany, EA; Hagag, AA; Hassan, SM | 1 |
| Armagan, HH; Armagan, I; Bayram, D; Candan, IA; Celik, E; Uğuz, AC; Yigit, A | 1 |
| Aslaner, A; Baştürk, A; Çakır, T; Durgut, H; Gül, M; Gül, S; Öğünç, AV; Oruç, MT; Polat, C; Sabuncuoglu, MZ; Şehirli, AÖ | 1 |
| Büning, J; Fellermann, K; Lehnert, H; Mackenroth, T; Möller, S; Olsen, V; Schmidt, KJ; Schröder, T; Sina, C | 1 |
| Chen, CJ; Cheng, TT; Lin, JC; Lin, KM | 1 |
| Abdel-Aziz, AA; Abdel-Bakky, MS; Abdelghany, TM; Ewees, MG | 1 |
| Hayakumo, T; Hirano, S; Ikura, Y; Iwai, Y; Kadota, C; Osuga, T | 1 |
| Carey, JJ; Conway, R; Coughlan, RJ; Low, C; O'Donnell, MJ | 1 |
| Vinken, M | 1 |
| Bonyadi, F; Ghavami, S; Marzban, H; Mazani, M; Moghadam, AR; Mohajeri, D; Namvaran-Abbas-Abad, A; Tutunchi, S; Yazdi, M; Łos, MJ | 1 |
| Bang, SY; Jeong, WK; Kim, JY; Kim, MY; Kim, TY; Kim, Y; Lee, HS; Sohn, JH | 1 |
| Chatterjee, M; De, S; Sen, T | 1 |
| Chen, Z; Li, XM; Li, XP; Li, ZG; Su, Y; Xiang, N; Yang, M; Zhang, MJ; Zhao, DB; Zhu, P; Zuo, XX | 1 |
| Guo, GL; Schumacher, JD | 1 |
| El-Hamamsy, M; Elbarbary, NS; Farahat, RK; Ismail, EA | 1 |
| Erdogan, E; Gurgor, PN; Ilgaz, Y; Oztas, E; Oztas, Y; Topal, T | 1 |
| Chen, DY; Chen, YH; Hung, WT; Lin, CH; Tang, KT | 1 |
| Ambrosetti, A; Balzarotti, M; Binder, M; Cavalli, F; Cwynarski, K; Deckert, M; Fabbri, A; Ferrari, A; Ferreri, AJ; Finke, J; Fox, CP; Gørløv, JS; Hemmaway, C; Hertenstein, B; Hess, G; Illerhaus, G; Johnson, P; Keller, U; Krause, SW; Levis, A; Linton, KM; Panse, J; Pisani, F; Politi, LS; Ponzoni, M; Pukrop, T; Pulczynski, E; Reni, M; Rosée, PL; Roth, A; Rudà, R; Schmoll, HJ; Schorb, E; Stilgenbauer, S; Torri, V; Tucci, A; Zucca, E | 1 |
| Abdelrahman, AM; Ibrahim, SA; Kelleni, MT | 1 |
| Doležalová, P; Fingerhutová, Š; Fráňová, J; Hoza, J; Kobrová, K; Linková, L; Němcová, D; Saifridová, M; Srp, R; Uher, M | 1 |
| Rau, R | 1 |
| Andrews, M; Armour, K; Baker, C; Foley, P; Gebauer, K; George, J; Gupta, M; Rademaker, M; Rubel, D; Sullivan, J | 1 |
| Exton, LS; Kirby, B; Mohd Mustapa, MF; Smith, CH; Warren, RB; Weatherhead, SC; Yesudian, PD | 1 |
| Buddington, RK; Harvey, RD; Howard, SC; McCormick, J; Pui, CH | 1 |
| Gerber, DA; LeCluyse, EL; Nguyen, DG; Norona, LM; Presnell, SC | 1 |
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| Millward-Sadler, GH; Ryan, TJ | 1 |
| Wong, VG | 1 |
| Dahl, MG | 1 |
| Block, JB; Carbone, PP; Haskell, CM; Leventhal, BG; Selawry, OS | 1 |
| Maibach, HI; Roenigk, HH; Weinstein, GD | 1 |
| Dahl, MG; Gregory, MM; Scheuer, PJ | 1 |
| Fenster, LF; Griesman, FA; Hammer, CJ | 1 |
| Baker, H | 1 |
| Farrar, WH; Filip, DJ; Harle, TS; Logue, GL | 1 |
| Tashima, CK | 1 |
| Bernard, J; Boiron, M; Bussel, A; Dreyfus, B; Jacquillat, C; Larrieu, MJ; Loisel, JP; Rouesse, T; Weil, M | 1 |
| Bender, AS | 1 |
| Mazzi, R | 1 |
| Dubin, HV; Harrell, ER | 3 |
| Akerman, M; Berge, G; Lundquist, A; Rorsman, H | 1 |
| Bourgeois-Spinasse, J; Grupper, C | 1 |
| Glasser, J; Hayes, TA | 1 |
| Cox, JW; Frost, P; Kalser, M; Millard, MM; Suringa, DW; Weinstein, GD | 1 |
| Bergfeld, WF; Hawk, WA; Owens, FJ; Roenigk, HH; St Jacques, R | 1 |
| Amblard, P; Dugois, P; Fillon, JP; Imbert, R; Martel, J | 1 |
| Price, LA | 1 |
| Barbier, P; Jacobs, E; Manaster, J; Robert, J | 1 |
| Taft, LI | 1 |
| Freireich, EJ; Henderson, ES; Hersh, EM; Wong, VG | 1 |
70 review(s) available for methotrexate and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Methotrexate Hepatotoxicity Monitoring Guidelines in Psoriasis and Rheumatoid Arthritis: Is There a Consensus?
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Consensus; Diabetes Mellitus, Type 2; Humans; Methotrexate; Psoriasis | 2021 |
Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies.
Topics: Alopecia; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dactinomycin; Female; Gestational Trophoblastic Disease; Humans; Methotrexate; Nausea; Pregnancy; Randomized Controlled Trials as Topic; Remission Induction; Risk; Treatment Outcome; Vomiting | 2021 |
Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis.
Topics: Alleles; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Neoplasms; Polymorphism, Genetic; Randomized Controlled Trials as Topic | 2022 |
Busting the myth of methotrexate chronic hepatotoxicity.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Methotrexate; Non-alcoholic Fatty Liver Disease | 2023 |
Is methotrexate hepatotoxicity associated with cumulative dose? A systematic review and meta-analysis.
Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Humans; Methotrexate | 2021 |
Current jakinibs for the treatment of rheumatoid arthritis: a systematic review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azetidines; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Kidney Diseases; Methotrexate; Piperidines; Purines; Pyrazoles; Pyrimidines; Randomized Controlled Trials as Topic; Sulfonamides; Treatment Outcome | 2021 |
Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Humans; Methotrexate; Psoriasis | 2021 |
Methotrexate Hepatotoxicity and the Impact of Nonalcoholic Fatty Liver Disease.
Topics: Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Diabetes Mellitus; Humans; Metabolic Syndrome; Methotrexate; Non-alcoholic Fatty Liver Disease; Obesity; Risk Factors | 2017 |
Liver Illness and Psoriatic Patients.
Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Inflammation; Liver; Liver Diseases; Methotrexate; Psoriasis | 2018 |
Hepatic methotrexate-associated lymphoproliferative disorders identified by multiple liver tumors: a case report and review of the literature.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Lymphoproliferative Disorders; Male; Methotrexate | 2019 |
The role of the MTHFR 677C>T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer.
Topics: Chemical and Drug Induced Liver Injury; Child; Female; Humans; Liver Neoplasms; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide | 2014 |
The impact of obesity and metabolic syndrome on chronic hepatitis B and drug-induced liver disease.
Topics: Acetaminophen; Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Insulin Resistance; Male; Metabolic Syndrome; Methotrexate; Non-alcoholic Fatty Liver Disease; Obesity; Prevalence; Risk Factors; Trans-Activators; Viral Regulatory and Accessory Proteins | 2014 |
Hepatotoxicity caused by methotrexate therapy in children with inflammatory bowel disease: a systematic review and meta-analysis.
Topics: Chemical and Drug Induced Liver Injury; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Liver; Meta-Analysis as Topic; Methotrexate; Prognosis | 2014 |
A review of methotrexate-associated hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Antirheumatic Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Monitoring; Folic Acid; Humans; Methotrexate; Peptide Fragments; Procollagen; Risk Factors | 2014 |
The liver in pediatric gastrointestinal disease.
Topics: Adolescent; Antibodies, Monoclonal; Azathioprine; Celiac Disease; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cholagogues and Choleretics; Cholangitis, Sclerosing; Cystic Fibrosis; Humans; Infant; Inflammatory Bowel Diseases; Infliximab; Liver Diseases; Liver Function Tests; Mercaptopurine; Methotrexate; Tumor Necrosis Factor-alpha; Ursodeoxycholic Acid | 2014 |
Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials.
Topics: Chemical and Drug Induced Liver Injury; Humans; Immunosuppressive Agents; Methotrexate; Risk; Risk Assessment | 2015 |
Adverse Outcome Pathways and Drug-Induced Liver Injury Testing.
Topics: Bosentan; Chemical and Drug Induced Liver Injury; Cholestasis; Fatty Liver; Humans; Liver Cirrhosis; Methotrexate; Quantitative Structure-Activity Relationship; Sulfonamides; Valproic Acid | 2015 |
Mechanistic review of drug-induced steatohepatitis.
Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid | 2015 |
[Methotrexate].
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Evidence-Based Medicine; Humans; Immunosuppressive Agents; Methotrexate; Treatment Outcome | 2016 |
The Australasian Psoriasis Collaboration view on methotrexate for psoriasis in the Australasian setting.
Topics: Alcohol Drinking; Australia; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Monitoring; Drug Therapy, Combination; Humans; Liver Diseases; Methotrexate; New Zealand; Psoriasis; Reproductive Health | 2017 |
Preventing and Managing Toxicities of High-Dose Methotrexate.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Bone Marrow; Chemical and Drug Induced Liver Injury; Crystallization; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Methotrexate; Mucositis | 2016 |
Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Eruptions; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Immunosuppressive Agents; Leucovorin; Liver Diseases; Methotrexate; Psoriasis; Randomized Controlled Trials as Topic | 2009 |
Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Humans; Infections; Long-Term Care; Methotrexate; Neoplasms; Pneumonia; Risk Factors | 2009 |
Assessment and management of methotrexate hepatotoxicity in psoriasis patients: report from a consensus conference to evaluate current practice and identify key questions toward optimizing methotrexate use in the clinic.
Topics: Biomarkers; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Dietary Supplements; Folic Acid; Humans; Liver; Methotrexate; Pharmacogenetics; Psoriasis; Risk Factors | 2011 |
Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity.
Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Humans; Incidence; Methotrexate; Psoriasis; Risk Factors; Treatment Outcome | 2011 |
Incidence of liver toxicity in inflammatory bowel disease patients treated with methotrexate: a meta-analysis of clinical trials.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Female; Humans; Incidence; Inflammatory Bowel Diseases; Liver; Male; Methotrexate; Middle Aged; Transaminases; Treatment Outcome; Young Adult | 2012 |
[Tocilizumab in rheumatoid arthritis].
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Disease Susceptibility; Drug Therapy, Combination; Humans; Hypercholesterolemia; Infections; Methotrexate; Multicenter Studies as Topic; Receptors, Interleukin-6 | 2011 |
Genetic risk factors for drug-induced liver injury in rheumatoid arthritis patients using low-dose methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Polymorphism, Genetic; Retrospective Studies; Risk Factors | 2013 |
A retrospective review of methotrexate-induced hepatotoxicity among patients with psoriasis in a tertiary dermatology center in Malaysia.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; Humans; Liver; Malaysia; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Severity of Illness Index; Tertiary Care Centers; Time Factors; Young Adult | 2013 |
Monitoring methotrexate hepatic toxicity in rheumatoid arthritis: is it time to update the guidelines?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Monitoring; Hospitals, Special; Humans; Methotrexate; Practice Guidelines as Topic; Rheumatology | 2002 |
Not yet time to change the guidelines for monitoring methotrexate liver toxicity: they have served us well.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Monitoring; Humans; Methotrexate; Practice Guidelines as Topic; Rheumatology | 2002 |
Methotrexate-associated liver toxicity in a patient with breast cancer: case report and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Female; Humans; Methotrexate; Middle Aged; Mitoxantrone | 2002 |
Review article: the evolving role of liver biopsy.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Hepatitis B; Hepatitis C; Humans; Liver; Methotrexate | 2004 |
Oral effects of low-dose methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Bone Marrow; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Female; Folic Acid Antagonists; Gastrointestinal Tract; Humans; Liver; Male; Methotrexate; Middle Aged; Mouth Mucosa; Oral Ulcer; Retrospective Studies; Stomatitis | 2005 |
[Liver damage in methotrexate-treated patients. When liver biopsy is necessary in the follow-up?].
Topics: Arthritis, Rheumatoid; Biopsy, Needle; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Psoriasis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index | 2005 |
[Adverse effects of conventional DMARDs and biologic DMARDs].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Cysteine; Drug Eruptions; Drug Hypersensitivity; Hematologic Diseases; Humans; Immune System Diseases; Infliximab; Isoxazoles; Kidney Diseases; Leflunomide; Lung Diseases; Methotrexate | 2007 |
Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 1983 |
Methotrexate therapy of psoriasis. Effect and side effects with particular reference to hepatic changes. A survey.
Topics: Bone Marrow; Chemical and Drug Induced Liver Injury; Chemistry; Drug Evaluation; History, 20th Century; Humans; Liver; Methotrexate; Microscopy, Electron; Psoriasis | 1980 |
[Toxic lesions caused by cytostatic drugs].
Topics: Alopecia; Antineoplastic Agents; Arrhythmias, Cardiac; Blood Platelets; Blood Transfusion; Bone Marrow; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diarrhea; Digestive System; Doxorubicin; Female; Hair; Humans; Kidney Diseases; Lung; Male; Methotrexate; Methotrimeprazine; Mutation; Pericarditis; Pregnancy; Pulmonary Fibrosis; Thrombocytopenia; Vincristine | 1980 |
Methotrexate guidelines--revised.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Interactions; Follow-Up Studies; Humans; Liver; Methotrexate; Psoriasis | 1982 |
Drug-induced chronic liver disease, with emphasis on chronic active hepatitis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Dantrolene; Diagnosis, Differential; Fat Necrosis; Female; Hepatitis, Viral, Human; Humans; Liver Cirrhosis, Biliary; Male; Methotrexate; Methyldopa; Middle Aged; Nitrofurantoin; Oxyphenisatin Acetate; Perhexiline | 1981 |
Monitoring patients taking methotrexate for hepatotoxicity. Does the standard of care match published guidelines?
Topics: Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Clinical Protocols; Connecticut; Drug Monitoring; Follow-Up Studies; Gastroenterology; Humans; Liver; Liver Diseases; Massachusetts; Methotrexate; Practice Guidelines as Topic; Psoriasis; Referral and Consultation | 1994 |
Methotrexate: adverse reactions and major toxicities.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Hematologic Diseases; Humans; Lung Diseases; Methotrexate | 1994 |
[Weekly low-dose methotrexate in rheumatoid arthritis. Review of the literature].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Interactions; Hematologic Diseases; Humans; Immune System Diseases; Interleukins; Leukocytes, Mononuclear; Lung Diseases; Methotrexate; Neutrophils | 1993 |
Methotrexate: new mechanisms and old toxicities.
Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Leukotriene B4; Lung Diseases; Methotrexate | 1993 |
Methotrexate hepatotoxicity and the role of routine liver biopsy: a collective opinion.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Humans; Liver; Methotrexate; Psoriasis | 1995 |
Review article: methotrexate in gastroenterology--dangerous villain or simply misunderstood?
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Gastroenterology; Gastrointestinal Agents; Humans; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Methotrexate; Psoriasis | 1996 |
Methotrexate hepatotoxicity.
Topics: Antirheumatic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Drug Monitoring; Guidelines as Topic; Humans; Liver; Methotrexate; Rheumatic Diseases | 1997 |
Methotrexate for sarcoidosis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Humans; Immunosuppressive Agents; Liver Diseases; Lung Diseases; Methotrexate; Safety; Sarcoidosis; Treatment Outcome | 1998 |
[Methotrexate in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female; Humans; Male; Methotrexate; Patient Selection; Pneumonia; Risk Assessment; Treatment Outcome | 1996 |
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical and Drug Induced Liver Injury; Daunorubicin; Doxorubicin; Female; Fetus; Folic Acid Antagonists; Follow-Up Studies; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infertility, Female; Infertility, Male; Liver; Lung Diseases; Male; Mercaptopurine; Methotrexate; Myocarditis; Neoplasms; Ovary; Pregnancy; Procarbazine; Streptozocin; Testis; Urologic Diseases | 1975 |
The clinical pharmacology of antineoplastic agents (first of two parts).
Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug Induced Liver Injury; Depression, Chemical; DNA, Neoplasm; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Kidney Diseases; Liver; Lung Diseases; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1975 |
Hepatic drug metabolism and adverse hepatic drug reactions.
Topics: Adaptation, Biological; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Endoplasmic Reticulum; Enzyme Induction; Free Radicals; Glucose-6-Phosphatase; Halothane; Humans; Liver; Methotrexate; Microsomes, Liver; Oxyphenisatin Acetate; Rats; Vinyl Chloride | 1975 |
Long-term effects on the liver.
Topics: Anabolic Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Contraceptives, Oral, Hormonal; Humans; Lipofuscin; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Methotrexate; Oxyphenisatin Acetate; Phenacetin | 1975 |
Drug-induced chronic hepatic disease.
Topics: Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Liver; Hemangioendothelioma; Hexestrol; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Liver Neoplasms; Methotrexate; Necrosis; Oxyphenisatin Acetate | 1979 |
Methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Ficusin; Humans; Methotrexate; Psoriasis; Ultraviolet Therapy | 1977 |
Late side effects of treatment: skeletal, genetic, central nervous system, and oncogenic.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents; Busulfan; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Female; Heart Diseases; Humans; Lung Diseases; Male; Menstruation Disturbances; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Radiation-Induced; Pregnancy; Radiotherapy; Urinary Bladder Diseases | 1976 |
The risks of antimalarial retinopathy, azathioprine lymphoma and methotrexate hepatotoxicity during the treatment of rheumatoid arthritis.
Topics: Antimalarials; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Lymphoma; Methotrexate; Retinal Diseases; Risk Factors | 1990 |
Methotrexate in rheumatoid arthritis. Feedback on American College of Physicians guidelines.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Methotrexate; Societies, Medical; United States | 1989 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Depression, Chemical; Dermatomyositis; Drug Evaluation; Female; Fertility; Gastrointestinal Diseases; Granulomatosis with Polyangiitis; Humans; Leukopenia; Lupus Erythematosus, Systemic; Male; Methotrexate; Myositis; Neoplasms; Polyarteritis Nodosa; Psoriasis; Pulmonary Fibrosis; Rheumatic Diseases | 1986 |
[Drug-induced hepatic lesions].
Topics: Adenoma; Amiodarone; Amphetamines; Antineoplastic Agents; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Contraceptive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hemangiosarcoma; Humans; Liver Cirrhosis; Liver Neoplasms; Methotrexate | 1986 |
Methotrexate in psoriasis: revised guidelines.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Humans; Liver; Liver Diseases; Methotrexate; Patient Education as Topic; Psoriasis | 1988 |
Methotrexate-induced chronic liver injury: guidelines for detection and prevention. The ACG Committee on FDA-related matters. American College of Gastroenterology.
Topics: Chemical and Drug Induced Liver Injury; Chronic Disease; Humans; Liver Diseases; Methotrexate; Prognosis | 1988 |
[Late effects of cancer chemotherapy].
Topics: Antineoplastic Agents; Bone and Bones; Chemical and Drug Induced Liver Injury; Cisplatin; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney Diseases; Liver Cirrhosis; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Pituitary Gland; Pregnancy; Testis | 1987 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Gold; Humans; Immunosuppression Therapy; Methotrexate; Pancytopenia; Penicillamine; Placebos; Psoriasis | 1985 |
Longterm methotrexate therapy in rheumatoid arthritis: a review.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Drug Resistance; Gold; Humans; Hydroxychloroquine; Liver Diseases; Liver Function Tests; Methotrexate; Penicillamine; Prednisone; Psoriasis; Risk | 1985 |
Methotrexate in the treatment of psoriasis.
Topics: Abnormalities, Drug-Induced; Bone Marrow; Chemical and Drug Induced Liver Injury; Female; Hematologic Diseases; Humans; Kidney Diseases; Leucovorin; Liver; Methotrexate; Pregnancy; Psoriasis; Skin | 1972 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Halothane; Humans; Imipramine; Liver; Methotrexate; Methyldopa; Nicotinic Acids; Oxacillin; Phenylbutazone; Testosterone; Tetracycline | 1974 |
Methotrexate and the liver.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Hepatomegaly; Humans; Liver Cirrhosis; Liver Function Tests; Methotrexate; Psoriasis; Splenomegaly | 1969 |
32 trial(s) available for methotrexate and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Genetics are not likely to offer clinically useful predictions for elevated liver enzyme levels in patients using low dose methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Genome-Wide Association Study; Humans; Methotrexate; Risk Factors | 2022 |
Efficacy and Safety of Tocilizumab for Polyarticular-Course Juvenile Idiopathic Arthritis in the Open-Label Two-Year Extension of a Phase III Trial.
Topics: Adolescent; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Bronchitis; Cellulitis; Chemical and Drug Induced Liver Injury; Chickenpox; Child; Child, Preschool; Female; Glucocorticoids; Humans; Infections; Male; Methotrexate; Patient Reported Outcome Measures; Pneumonia; Treatment Outcome | 2021 |
Comparison of two dose escalation strategies of methotrexate in active rheumatoid arthritis: a multicentre, parallel group, randomised controlled trial.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Thrombocytopenia; Treatment Outcome; Young Adult | 2021 |
Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cholagogues and Choleretics; Female; Humans; Liver; Liver Function Tests; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Ursodeoxycholic Acid; Vitamin E; Vitamins | 2018 |
Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Leflunomide; Male; Methotrexate; Middle Aged; Morphinans; Treatment Outcome | 2019 |
Safety and clinical activity of 5-aza-2'-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Decitabine; Dexamethasone; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Hyperglycemia; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Vincristine; Young Adult | 2014 |
Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cuminum; Female; Humans; Infant; Leucovorin; Liver; Male; Methotrexate; Plant Oils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Seeds | 2015 |
Assessment of Substantial Liver Fibrosis by Real-time Shear Wave Elastography in Methotrexate-Treated Patients With Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Causality; Chemical and Drug Induced Liver Injury; Comorbidity; Computer Systems; Elasticity Imaging Techniques; Female; Humans; Incidence; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Reproducibility of Results; Republic of Korea; Risk Factors; Sensitivity and Specificity | 2015 |
Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glucosides; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Paeonia; Treatment Outcome; Young Adult | 2015 |
ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.
Topics: Adolescent; Antioxidants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Double-Blind Method; Fatty Acids, Omega-3; Female; Glutathione Peroxidase; Humans; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Superoxide Dismutase | 2016 |
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Comparative Effectiveness Research; Cytarabine; Death, Sudden; Denmark; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Gastrointestinal Diseases; Germany; Heart Injuries; Hematopoietic Stem Cell Transplantation; Humans; Hyperglycemia; Induction Chemotherapy; Infections; Intraocular Lymphoma; Italy; Kaplan-Meier Estimate; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mucositis; Neurotoxicity Syndromes; Neutropenia; Optic Nerve Neoplasms; Poisoning; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Stroke; Switzerland; Thiotepa; Thrombocytopenia; Thrombosis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; United Kingdom | 2016 |
Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Therapy, Computer-Assisted; Epidemiologic Methods; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 2010 |
Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Dexamethasone; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Assessment; Survival Analysis; Treatment Outcome; Vincristine | 2010 |
[Clinical tolerance of high-dose methotrexate used in consolidation therapy in children with acute lymphoblastic leukemia].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Incidence; Infant; Infections; Male; Methotrexate; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vomiting | 2010 |
Evaluation of liver fibrosis by transient elastography in methotrexate treated patients.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Liver Cirrhosis; Logistic Models; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis; Sensitivity and Specificity; Single-Blind Method | 2011 |
Risk of hepatotoxicity with add-on leflunomide in rheumatoid arthritis patients.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prospective Studies; Risk | 2011 |
Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow
Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Hemorrhage; Humans; Idarubicin; Infections; Leukemia, Promyelocytic, Acute; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Middle Aged; Remission Induction; Treatment Outcome; Vomiting | 2002 |
Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Chemical and Drug Induced Liver Injury; Creatinine; Digestive System; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sex Factors; Treatment Outcome | 2003 |
Relapsed or refractory gestational trophoblastic neoplasia treated with the etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EP-EMA) regimen.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cisplatin; Cyclophosphamide; Dactinomycin; Dose-Response Relationship, Drug; Etoposide; Female; Follow-Up Studies; Gestational Trophoblastic Disease; Humans; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pregnancy; Pregnancy Outcome; Remission Induction; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vincristine | 2007 |
Methotrexate in psoriasis with and without leucovorin: effect of different dosage schedules on acute liver toxicity.
Topics: Administration, Oral; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Humans; Injections, Intramuscular; Injections, Intravenous; Leucovorin; Methotrexate; Psoriasis | 1982 |
Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged | 1983 |
Significant changes in serum AST across hepatic histological biopsy grades: prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Sensitivity and Specificity | 1996 |
Serum type III procollagen aminopeptide for assessing liver damage in methotrexate-treated psoriatic patients.
Topics: Adult; Aged; Biomarkers; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Follow-Up Studies; Humans; Laminin; Liver Diseases; Methotrexate; Middle Aged; Peptide Fragments; Procollagen; Psoriasis; Sensitivity and Specificity | 1996 |
Low-dose methotrexate in the management of Chinese patients with steroid-dependent asthma.
Topics: Adult; Aged; Asthma; Chemical and Drug Induced Liver Injury; China; Hong Kong; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Respiratory Function Tests | 1996 |
Hepatic toxicity caused by adjuvant CMF/CNF in breast cancer patients and reversal by tamoxifen.
Topics: Acetyltransferases; Adult; Alkaline Phosphatase; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; gamma-Glutamyltransferase; Humans; Liver Diseases; Methotrexate; Middle Aged; Mitoxantrone; Tamoxifen | 1997 |
Effect of combination therapy with cyclosporine and methotrexate on liver function test results in rheumatoid arthritis.
Topics: Alkaline Phosphatase; Antirheumatic Agents; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate | 1997 |
Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Deafness; Disease Progression; Disease-Free Survival; Etoposide; Follow-Up Studies; Glioma; Hearing Loss; Hematologic Diseases; Humans; Ifosfamide; Infections; Life Tables; Lomustine; Medulloblastoma; Methotrexate; Prognosis; Radiotherapy, Adjuvant; Remission Induction; Vincristine | 1998 |
A prospective study of the effects of weekly oral methotrexate on liver biopsy.
Topics: Administration, Oral; Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1975 |
A pilot study of intermediate-dose methotrexate and cytosine arabinoside, "spread-out" or "up-front," in continuation therapy for childhood non-T, non-B acute lymphoblastic leukemia. A Pediatric Oncology Group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Fever; Humans; Infant; Infections; Length of Stay; Leukocyte Count; Male; Methotrexate; Neutropenia; Pilot Projects; Platelet Count; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate | 1991 |
Transient acute hepatotoxicity of high-dose methotrexate therapy during childhood.
Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Time Factors | 1987 |
Short term efficacy of methotrexate in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Gold; Humans; Immunosuppression Therapy; Methotrexate; Pancytopenia; Penicillamine; Placebos; Psoriasis | 1985 |
Historical perspective on the use of methotrexate for the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aminopterin; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Double-Blind Method; Female; History, 20th Century; Humans; Male; Methotrexate; Pneumonia; Psoriasis; Random Allocation | 1985 |
396 other study(ies) available for methotrexate and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Glutathione; Immunosuppressive Agents; Lipid Peroxidation; Liver Function Tests; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Placenta; Placental Extracts; Pregnancy; Rats; Rats, Wistar | 2021 |
Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Gene Expression Regulation; Genome-Wide Association Study; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Janus Kinase 1; Liver; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Young Adult | 2021 |
A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Caspase 3; Chemical and Drug Induced Liver Injury; Hematoxylin; Interleukin-1beta; Liver; Methotrexate; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Sirtuins; Tumor Suppressor Protein p53 | 2022 |
Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Methotrexate; Nebivolol; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats | 2022 |
Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Flavonoids; Inflammation; Liver; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2022 |
In-vitro and in-vivo functional observation studies to establish therapeutic potential of alpha-ketoglutarate against methotrexate induced liver injury.
Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Glycine; Ketoglutaric Acids; Liver; Methotrexate; Oxidative Stress; Rats | 2021 |
Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice.
Topics: Animals; Catechin; Chemical and Drug Induced Liver Injury; Liver; Male; Methotrexate; Mice; Oxidative Stress | 2021 |
Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Carnitine; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley | 2022 |
Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Humans; Liver Cirrhosis; Liver Diseases; Methotrexate | 2022 |
Risk Factors for Hepatic Toxicity of High-dose Methotrexate in Patients With Osteosarcoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Female; History, 21st Century; Humans; Japan; Male; Methotrexate; Osteosarcoma; Retrospective Studies; Risk Factors; Young Adult | 2022 |
Effect of gervital in attenuating hepatotoxicity caused by methotrexate or azathioprine in adult albino rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced Liver Injury; Glutamates; Grape Seed Extract; Liver; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2022 |
Effect of an Extract from the Egyptian Sea Cucumber, Bohadschia marmorata, on Methotrexate-Induced Hepatorenal Toxicity in Male Mice.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Methotrexate; Mice; Protective Agents; Sea Cucumbers; Serum Albumin; Superoxide Dismutase | 2022 |
Synthesis, characterization and protection effect of black rice anthocyanins nano-composite against hepatotoxicity induced by methotrexate in rats.
Topics: Animals; Anthocyanins; Chemical and Drug Induced Liver Injury; Methotrexate; Oryza; Oxidative Stress; Rats | 2022 |
Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice.
Topics: Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Fatty Acids, Omega-3; Glutathione; Male; Methotrexate; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Oxidative Stress; Vitamins | 2022 |
Protective effect of dexpanthenol against methotrexate-induced liver oxidative toxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Liver; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2023 |
Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3-gallate.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Catechin; Chemical and Drug Induced Liver Injury; Liver; Methotrexate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2023 |
Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the TLR4/NF-κB pathway and NLRP3 inflammasome/caspase 1 axis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 1; Chemical and Drug Induced Liver Injury; Cytokines; Flavonols; Glutathione; Inflammasomes; Interleukin-18; Interleukin-1beta; Malondialdehyde; Methotrexate; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Rats; Toll-Like Receptor 4 | 2022 |
Risk factors for high-dose methotrexate associated toxicities in patients with primary central nervous system lymphoma.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Central Nervous System; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma; Methotrexate; Risk Factors; Vindesine | 2022 |
Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Catalase; Cell Death; Chemical and Drug Induced Liver Injury; Glutathione; Inflammation; Interleukin-6; Liver; Malondialdehyde; Methotrexate; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Transaminases; Tumor Necrosis Factor-alpha | 2022 |
Empagliflozin mitigates methotrexate-induced hepatotoxicity: Targeting ASK-1/JNK/Caspase-3 pathway.
Topics: Animals; Antioxidants; Caspase 3; Chemical and Drug Induced Liver Injury; Liver; Male; Methotrexate; Mice; Oxidative Stress | 2023 |
Melissa Officinalis L. aqueous extract pretreatment decreases methotrexate-induced hepatotoxicity at lower dose and increases
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Melissa; Methotrexate; Phytic Acid; Rats; Rats, Wistar | 2023 |
Methotrexate-Induced Liver Injury Is Associated with Oxidative Stress, Impaired Mitochondrial Respiration, and Endoplasmic Reticulum Stress In Vitro.
Topics: Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Endoplasmic Reticulum Stress; Glutathione; Humans; Liver; Liver Cirrhosis; Methotrexate; Oxidative Stress | 2022 |
Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.
Topics: Adaptor Proteins, Signal Transducing; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Genome-Wide Association Study; Humans; Methotrexate; Polymorphism, Single Nucleotide | 2023 |
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Body Weight; Caspase 3; Chemical and Drug Induced Liver Injury; Flavonoids; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction | 2023 |
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
Topics: Animals; Chemical and Drug Induced Liver Injury; Melatonin; Methotrexate; Phosphatidylinositol 3-Kinases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Rats; TOR Serine-Threonine Kinases | 2023 |
Germline genetic variations in methotrexate pathway are associated with pharmacokinetics, outcome, and toxicity in patients with primary central nervous system lymphoma.
Topics: Central Nervous System; Chemical and Drug Induced Liver Injury; Germ Cells; Humans; Lymphoma; Methotrexate; Polymorphism, Single Nucleotide; Retrospective Studies | 2023 |
Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.
Topics: Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Methotrexate; Mice; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thioctic Acid; Vitamins | 2023 |
Effect of co-medications and potential risk factors of high-dose methotrexate-mediated acute hepatotoxicity in patients with osteosarcoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Disease Progression; Female; Humans; Methotrexate; Osteosarcoma; Proton Pump Inhibitors; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 2023 |
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase 3; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; KATP Channels; Liver; Male; Methotrexate; Nicorandil; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2023 |
A semimechanistic pharmacokinetic/pharmacodynamic model for alanine aminotransferase-based hepatotoxicity of methotrexate in paediatric patients with acute lymphoid leukaemia.
Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2023 |
The beneficial effects of l-carnitine and infliximab in methotrexate-induced hepatotoxicity: Emphasis on Notch1/Hes-1 signaling.
Topics: Animals; Anti-Inflammatory Agents; Carnitine; Chemical and Drug Induced Liver Injury; Infliximab; Liver; Methotrexate; Oxidative Stress; Rats; Receptor, Notch1; Signal Transduction; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2023 |
Certolizumab-induced liver injury: as assessed for causality by the updated RUCAM.
Topics: Abdominal Pain; Certolizumab Pegol; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Diabetes Mellitus, Type 2; Female; Humans; Methotrexate | 2023 |
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease.
Topics: Adult; Aged; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Crohn Disease; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2023 |
In vitro hepatotoxicity evaluation of methotrexate-loaded niosome formulation: fabrication, characterization and cell culture studies.
Topics: Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Humans; Liposomes; Methotrexate | 2023 |
The impact of Crocus sativus stigma against methotrexate-induced liver toxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Crocus; Iran; Lipid Peroxidation; Male; Methotrexate; Nitric Oxide; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase | 2019 |
Genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a multicenter cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Forecasting; Humans; Male; Methotrexate; Middle Aged; Models, Genetic; Treatment Outcome | 2020 |
Liver injury in children with long-term low-dose methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Child; Humans; Liver; Methotrexate | 2020 |
Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Synergism; Febuxostat; Female; Gout Suppressants; Hematopoiesis; Humans; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Neoplasm Proteins | 2019 |
Nimesulide increases the aldehyde oxidase activity of humans and rats.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; Humans; Male; Methotrexate; Rats; Rats, Wistar; Sulfonamides | 2020 |
Intravenous methotrexate at a dose of 1 g/m
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cerebrospinal Fluid; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Kaplan-Meier Estimate; Kidney Diseases; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Mucositis; Neoplasm Invasiveness; Prednisone; Proportional Hazards Models; Prospective Studies; Recurrence; Rituximab; Vincristine | 2020 |
Naringenin: a potential natural remedy against methotrexate-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Flavanones; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2022 |
Thrombotic microangiopathy and liver toxicity due to a combination therapy of leflunomide and methotrexate: a case report.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Leflunomide; Methotrexate; Middle Aged; Thrombotic Microangiopathies | 2020 |
Tranilast attenuates methotrexate-induced renal and hepatic toxicities: Role of apoptosis-induced tissue proliferation.
Topics: Animals; Apoptosis; Biomarkers; Caspase 8; Cell Proliferation; Chemical and Drug Induced Liver Injury; Ki-67 Antigen; Kidney; Liver; Liver Regeneration; Male; Methotrexate; Mice; ortho-Aminobenzoates; Oxidative Stress; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2020 |
Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hesperidin; Inflammation Mediators; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Protein p53 | 2020 |
The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes.
Topics: Animals; Chemical and Drug Induced Liver Injury; DNA-Binding Proteins; Drugs, Chinese Herbal; Immunosuppressive Agents; Inflammasomes; Inflammation; Liver; Methotrexate; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2020 |
Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling.
Topics: Animals; Antioxidants; Caffeic Acids; Chemical and Drug Induced Liver Injury; Inflammation; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Succinates; Up-Regulation | 2020 |
Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects.
Topics: Animals; Bosentan; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Flavonoids; Food-Drug Interactions; HEK293 Cells; Herb-Drug Interactions; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Molecular Conformation; Organic Anion Transporters; Rats, Sprague-Dawley; Structure-Activity Relationship | 2020 |
High-dose methotrexate-induced fulminant hepatic failure and pancytopenia in an acute lymphoblastic leukaemia paediatric patient.
Topics: Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response Relationship, Drug; Fatal Outcome; Heart Arrest; Humans; Liver Failure, Acute; Male; Methotrexate; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Carcinoma, Hepatocellular; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Hep G2 Cells; Humans; Inflammation Mediators; Liver; Liver Neoplasms; Male; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats | 2020 |
The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Inflammation Mediators; Kidney; Kidney Diseases; Liver; Male; Methotrexate; Mice; Moringa oleifera; Oxidative Stress; Plant Extracts; Plant Leaves; Signal Transduction | 2020 |
Folinic acid alleviates side effects of methotrexate in arthritis patients with side effects despite folic acid supplementation: an observational cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis; Arthritis, Psoriatic; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Substitution; Female; Folic Acid; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Nausea; Oral Ulcer; Retrospective Studies; Rheumatic Fever; Treatment Failure; Vitamin B Complex | 2020 |
Psoriasis, transient elastography and methotrexate: monitoring at a tertiary hospital.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Dose-Response Relationship, Drug; Female; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis; Tertiary Care Centers | 2021 |
Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach.
Topics: Acute Kidney Injury; Animals; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Female; Glycyrrhiza; Methotrexate; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Wistar | 2020 |
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Topics: Alanine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Janus Kinase 1; Liver; Male; Methotrexate; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Quinolones; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Transcription Factor RelA | 2020 |
Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase.
Topics: Animals; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Male; Methotrexate; Rats; Rats, Wistar; Receptor-Interacting Protein Serine-Threonine Kinases; Treatment Outcome; Vitamin B 12 | 2020 |
Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Apigenin; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Interleukin-1beta; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Nitric Oxide; Oxidoreductases; Protective Agents; Rats, Wistar; Tumor Necrosis Factor-alpha | 2021 |
Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma.
Topics: Acute Kidney Injury; Adult; Aged; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Homozygote; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies | 2021 |
Methotrexate Hepatotoxicity in Children with Juvenile Idiopathic Arthritis: A Single-Center Study.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate | 2021 |
High-dose methotrexate-induced reversible grade 4 hyperbilirubinaemia and transaminitis in an adolescent with Burkitt Leukaemia.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Humans; Hyperbilirubinemia; Male; Methotrexate; Severity of Illness Index | 2021 |
Evaluation of the hepatoprotective activity of Pulicaria incisa subspecies candolleana and in silico screening of its isolated phenolics.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Computer Simulation; Cyclooxygenase 2; Flavonoids; Methotrexate; Molecular Docking Simulation; Phenols; Phospholipases A2; Phytochemicals; Plant Extracts; Protective Agents; Pulicaria; Rats, Wistar; Silymarin | 2021 |
The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Apoptosis; Chemical and Drug Induced Liver Injury; Inflammation; Kidney; Kidney Diseases; Luteolin; Male; Methotrexate; Oxidative Stress; Protective Agents; Rats | 2021 |
Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: A population-based study.
Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Denmark; Female; Follow-Up Studies; Humans; Incidence; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis; Risk Assessment; Risk Factors; Severity of Illness Index | 2021 |
Safety of the combined use of methotrexate and acitretin in a dermatology hospital setting.
Topics: Acitretin; Adult; Aged; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Skin Diseases | 2021 |
The hepatoprotective effect of the combination of glucosamine derivatives with quercetin against methotrexate-induced liver toxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glucosamine; Methotrexate; Oxidative Stress; Quercetin; Rats; Rats, Wistar | 2020 |
Apigenin alleviates methotrexate-induced liver and kidney injury in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apigenin; Chemical and Drug Induced Liver Injury; Kidney Diseases; Male; Methotrexate; Mice; Molecular Structure; Oxidative Stress | 2021 |
Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Down-Regulation; Glycyrrhiza; Humans; Inflammation; Isoflavones; Liver; Methotrexate; Mice; NF-kappa B; Oxidative Stress; Phenols; Protective Agents; Tumor Necrosis Factor-alpha | 2021 |
This Month in JAAD: June 2021.
Topics: Calcineurin Inhibitors; Chemical and Drug Induced Liver Injury; Dermoscopy; Humans; Melanoma; Methotrexate; Phototherapy; Psoriasis; Risk Assessment; Risk Factors; Skin; Skin Neoplasms; Skin Pigmentation; Vitiligo | 2021 |
[Research progress on protective effect of traditional Chinese medicine and natural medicine on methotrexate-induced liver toxicity].
Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Medicine, Chinese Traditional; Methotrexate; Oxidative Stress | 2021 |
RETRACTED: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Benzhydryl Compounds; Caspase 3; Chemical and Drug Induced Liver Injury; Glucosides; Heme Oxygenase (Decyclizing); Hesperidin; HSP72 Heat-Shock Proteins; Kelch-Like ECH-Associated Protein 1; Male; Methotrexate; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
Initial methotrexate dosage is not associated with an increased risk of liver toxicity in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Retrospective Studies | 2021 |
A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic.
Topics: Acitretin; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Contraindications, Drug; COVID-19; Cyclosporine; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nails; Pandemics; Photopheresis; Psoriasis; Quality of Life; SARS-CoV-2; Severity of Illness Index; Ultraviolet Therapy | 2021 |
Association between SNPs and hepatotoxicity in patients with primary central nervous system lymphoma on high-dose methotrexate therapy.
Topics: Adult; Aged; Aminohydrolases; Asian People; Central Nervous System; Chemical and Drug Induced Liver Injury; Cyclin D1; Female; Formate-Tetrahydrofolate Ligase; Genotype; Humans; Introns; Liver; Lymphoma; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Multidrug Resistance-Associated Protein 2; Multienzyme Complexes; Odds Ratio; Polymorphism, Single Nucleotide; Thymidylate Synthase | 2021 |
A possible interaction between favipiravir and methotrexate: Drug-induced hepatotoxicity in a patient with osteosarcoma.
Topics: Amides; Antiviral Agents; Bone Neoplasms; Chemical and Drug Induced Liver Injury; COVID-19; Humans; Methotrexate; Osteosarcoma; Pharmaceutical Preparations; Pyrazines; RNA, Viral; SARS-CoV-2 | 2022 |
Hepatoprotective effect of sitagliptin against methotrexate induced liver toxicity.
Topics: Animals; Apoptosis; Blotting, Western; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methotrexate; Mice; Necrosis; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction; Sitagliptin Phosphate | 2017 |
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.
Topics: Aged; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Risk | 2017 |
Transient Elastography May Improve Detection of Liver Fibrosis in Psoriasis Patients Treated with Methotrexate.
Topics: Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Psoriasis; Time Factors; Treatment Outcome | 2017 |
Significant curative functions of the mesenchymal stem cells on methotrexate-induced kidney and liver injuries in rats.
Topics: Acute Kidney Injury; Allografts; Animals; Chemical and Drug Induced Liver Injury; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methotrexate; Rats; Rats, Wistar | 2017 |
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats.
Topics: Animals; Apoptosis; Berberine; Chemical and Drug Induced Liver Injury; Heme Oxygenase (Decyclizing); Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; PPAR gamma; Rats, Wistar; Signal Transduction | 2017 |
Methotrexate in the Treatment of Autoimmune Hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Methotrexate | 2018 |
Ambulatory High-dose Methotrexate Administration in Pediatric Osteosarcoma Patients at a Single Institution in Argentina.
Topics: Adolescent; Algorithms; Ambulatory Care; Anemia; Antacids; Argentina; Chemical and Drug Induced Liver Injury; Child; Diarrhea; Female; Humans; Hydrogen-Ion Concentration; Leucovorin; Leukopenia; Male; Methotrexate; Mucositis; Neutropenia; Osteosarcoma; Retrospective Studies; Thrombocytopenia; Vomiting | 2017 |
Recombinant human erythropoietin prevents etoposide- and methotrexate-induced toxicity in kidney and liver tissues via the regulation of oxidative damage and genotoxicity in Wistar rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Catalase; Chemical and Drug Induced Liver Injury; DNA Damage; Erythropoietin; Etoposide; Glutathione; Kidney; Kidney Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Protective Agents; Rats, Wistar; Recombinant Proteins | 2018 |
Protective effects of gallic acid against methotrexate-induced toxicity in rats.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Biomarkers; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gallic Acid; Immunohistochemistry; Liver Function Tests; Male; Methotrexate; Multivariate Analysis; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reference Values; Risk Assessment; Superoxide Dismutase | 2018 |
Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats.
Topics: Alanine Transaminase; Animals; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Berberine; Chemical and Drug Induced Liver Injury; Glutathione; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2018 |
Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
Spirulina ameliorates methotrexate hepatotoxicity via antioxidant, immune stimulation, and proinflammatory cytokines and apoptotic proteins modulation.
Topics: Adjuvants, Immunologic; Animals; Antimetabolites; Antioxidants; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Cytokines; Leukocyte Count; Lipid Peroxidation; Male; Methotrexate; Necrosis; Plant Extracts; Rats; Rats, Wistar; Spirulina; Spleen | 2018 |
Ellagic acid as a potential antioxidant, alleviates methotrexate-induced hepatotoxicity in male rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ellagic Acid; Glutathione; Immunosuppressive Agents; Liver; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2019 |
Allylpyrocatechol attenuates methotrexate-induced hepatotoxicity in a collagen-induced model of arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Cachexia; Catechols; Chemical and Drug Induced Liver Injury; Collagen Type II; Drug Synergism; Edema; Female; Gene Expression Regulation; Interleukin-6; Lipopolysaccharides; Liver; Male; Methotrexate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Splenomegaly; Tumor Necrosis Factor-alpha | 2018 |
Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations.
Topics: Animals; Apoptosis; Camelus; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Male; Methotrexate; Milk; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction | 2018 |
Abrogation of Hepatic Damage Induced by Anticancer Drug Methotrexate by Zobo (Hibiscus sabdariffa extract) Supplementation via Targeting Oxidative Hepatotoxicity in Rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Dietary Supplements; Disease Models, Animal; Hibiscus; Lipid Peroxidation; Liver; Male; Methotrexate; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar | 2019 |
Psoriatic patients with chronic viral hepatitis do not have an increased risk of liver cirrhosis despite long-term methotrexate use: Real-world data from a nationwide cohort study in Taiwan.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cohort Studies; Databases, Factual; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Long-Term Care; Male; Methotrexate; Middle Aged; Multivariate Analysis; Population Surveillance; Prevalence; Prognosis; Psoriasis; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Taiwan | 2018 |
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters.
Topics: Acute Kidney Injury; Adult; Agranulocytosis; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Humans; Male; Methotrexate; Pharmacogenetics; Posterior Leukoencephalopathy Syndrome; Solute Carrier Proteins | 2018 |
Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis.
Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Denmark; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Registries | 2018 |
Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freund's adjuvant induced arthritis with reduced hepatotoxicity.
Topics: Animals; Antioxidants; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Chemical and Drug Induced Liver Injury; Diterpenes; Drug Therapy, Combination; Enzymes; Freund's Adjuvant; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Joints; Liver; Male; Methotrexate; Oxidative Stress; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Transient Elastography for Monitoring for Hepatotoxicity in Rheumatoid Arthritis Patients on Long-term Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Humans; Methotrexate | 2021 |
Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Non-alcoholic Fatty Liver Disease; Risk Factors; Transaminases | 2018 |
Association between cumulative methotrexate dose, non-invasive scoring system and hepatic fibrosis detected by Fibroscan in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Fatty Liver; Female; Humans; Liver Cirrhosis; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2019 |
Association of C35T polymorphism in dihydrofolate reductase gene with toxicity of methotrexate in rheumatoid arthritis patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Genotype; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Treatment Outcome; Young Adult | 2019 |
Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Lipid Peroxidation; Liver; Male; Methotrexate; Molsidomine; Oxidative Stress; Rats, Wistar | 2019 |
Protective effect of inulin on methotrexate- induced liver toxicity in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response Relationship, Drug; Inulin; Liver; Male; Methotrexate; Mice; Mice, Inbred ICR; Random Allocation | 2019 |
Hepatoprotective activity of Erythrina × neillii leaf extract and characterization of its phytoconstituents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Erythrina; Flavonoids; Glycosides; Liver; Male; Methotrexate; Oxidative Stress; Plant Extracts; Plant Leaves; Protective Agents; Rats, Wistar; Tandem Mass Spectrometry | 2019 |
[Chemotherapy-induced liver injury in children].
Topics: Adolescent; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neoplasms | 2019 |
Low-dose methotrexate toxicity.
Topics: Autoimmune Diseases; Blood Cell Count; Bone Marrow; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Humans; Leucovorin; Lung Injury; Medication Errors; Methotrexate; Pancytopenia; Risk Factors | 2019 |
Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Arthritis, Rheumatoid; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Monitoring; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Retrospective Studies; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2019 |
The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.
Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Glutathione Peroxidase; Honey; Immunohistochemistry; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Olive Oil; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2019 |
Transaminitis and neutropenia are rare in patients on methotrexate: evidence from a large cohort of inflammatory arthritis patients.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Methotrexate; Neutropenia; Transaminases | 2019 |
Activation of pCREB/Nrf-2 signaling mediates re-positioning of liraglutide as hepato-protective for methotrexate -induced liver injury (MILI).
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hep G2 Cells; Humans; Liraglutide; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation.
Topics: Animals; Catalase; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glutathione Transferase; Lipid Peroxidation; Male; Methotrexate; Rats; Rats, Wistar; Resveratrol; Stilbenes; Thiobarbituric Acid Reactive Substances | 2013 |
Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients.
Topics: Adolescent; Adult; Aged; Biomarkers; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Proteomics; Psoriasis; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics, Nonparametric; Young Adult | 2013 |
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine | 2014 |
Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Caspase 3; Chemical and Drug Induced Liver Injury; Flavonoids; Glutathione; Immunohistochemistry; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 2014 |
Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antirheumatic Agents; Arthritis, Experimental; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Cymenes; Drug Therapy, Combination; Female; Freund's Adjuvant; Glutathione; Liver; Methotrexate; Monoterpenes; Rats; Rats, Wistar; Superoxide Dismutase; Synovitis | 2014 |
The concomitant use of meloxicam and methotrexate does not clearly increase the risk of silent kidney and liver damages in patients with rheumatoid arthritis.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Asymptomatic Diseases; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Therapy, Combination; Elasticity Imaging Techniques; Female; Humans; Liver; Male; Meloxicam; Methotrexate; Middle Aged; Odds Ratio; Prospective Studies; Thiazines; Thiazoles | 2014 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase | 2014 |
Identification of risk factors for elevated transaminases in methotrexate users through an electronic health record.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Cohort Studies; Electronic Health Records; Female; Humans; Liver Function Tests; Male; Methotrexate; Retrospective Studies; Risk Factors; Transaminases | 2014 |
Fibrosing cholestatic hepatitis after methotrexate and prednisone therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Therapy, Combination; Female; Hepatitis B; Humans; Liver Cirrhosis; Liver Failure, Acute; Liver Transplantation; Methotrexate; Middle Aged; Prednisone; Treatment Outcome | 2014 |
What is the optimal dose of high-dose methotrexate in the initial treatment of primary central nervous system lymphoma?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult | 2015 |
Validity of noninvasive markers of methotrexate-induced hepatotoxicity: a retrospective cohort study.
Topics: Adult; Aged; Biomarkers; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; Humans; Life Style; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Peptide Fragments; Pilot Projects; Procollagen; Psoriasis; Retrospective Studies; ROC Curve | 2014 |
The use of transient elastography and FibroTest for monitoring hepatotoxicity in patients receiving methotrexate for psoriasis.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Biopsy; Body Mass Index; Chemical and Drug Induced Liver Injury; Drug Monitoring; Elasticity Imaging Techniques; Fatty Liver; Female; Fibrosis; Humans; Immunosuppressive Agents; Liver; Male; Methotrexate; Middle Aged; Peptide Fragments; Procollagen; Psoriasis; Young Adult | 2014 |
Safety of less frequent monitoring of liver transaminases levels in rheumatic patients treated with low-dose methotrexate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antirheumatic Agents; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Clinical Enzyme Tests; Drug Monitoring; Female; Humans; Male; Methotrexate; Middle Aged; Patient Safety; Predictive Value of Tests; Retrospective Studies; Rheumatic Diseases; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2014 |
Practice gaps. Methotrexate-induced liver toxicity: replacing the liver biopsy.
Topics: Chemical and Drug Induced Liver Injury; Drug Monitoring; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Liver; Male; Methotrexate | 2014 |
Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.
Topics: Animals; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Feces; Kidney; Liver; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.
Topics: Animals; Atropine; Captopril; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Flutamide; Lamivudine; Liver; Male; Mannitol; Metabolomics; Methotrexate; Neomycin; Oxidative Stress; Phenytoin; Piperazines; Propylthiouracil; Rats; Rats, Wistar; Streptomycin; Triazoles; Valproic Acid; Vancomycin; Zidovudine | 2014 |
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
Topics: Acetylcysteine; Amifostine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Male; Methotrexate; Oxidative Stress; Rats, Sprague-Dawley; Time Factors | 2014 |
Risk of drug-induced liver injury from tumor necrosis factor antagonists.
Topics: Adult; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Female; Hospitals, University; Humans; Iceland; Immunologic Factors; Infliximab; Male; Methotrexate; Middle Aged; Prevalence; Prospective Studies; Risk Assessment; Tumor Necrosis Factor-alpha | 2015 |
Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Folic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methotrexate; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Is there a role for the MTHFR 677C>T and 1298A>C polymorphisms in methotrexate-induced liver toxicity?
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic | 2014 |
Automatic identification of methotrexate-induced liver toxicity in patients with rheumatoid arthritis from the electronic medical record.
Topics: Algorithms; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Electronic Health Records; Humans; Immunosuppressive Agents; Liver; Methotrexate | 2015 |
Statistical analysis of relation between plasma methotrexate concentration and toxicity in high-dose methotrexate therapy of childhood nonHodgkin lymphoma.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate | 2015 |
[Reccomendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on the use of methotrexate in inflammatory bowel disease].
Topics: Adult; Antiemetics; Antirheumatic Agents; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Folic Acid; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Methotrexate; Nausea; Ondansetron | 2015 |
Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Cytokines; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Hindlimb; Isoxazoles; Leflunomide; Liver Cirrhosis; Male; Methotrexate; Rats; Rats, Wistar; Spleen | 2015 |
Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Denmark; Genotype; Haplotypes; Humans; Infant; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Recurrence; Risk Assessment; Treatment Outcome | 2015 |
Methotrexate-related primary hepatic lymphoma in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Neoplasms; Lymphoma, B-Cell; Methotrexate; Middle Aged; Positron-Emission Tomography; Tomography, X-Ray Computed; Treatment Outcome | 2015 |
The effectiveness of risk communication regarding drug safety information: a nationwide survey by the Japanese public health insurance claims data.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Communication; Databases, Factual; Female; Humans; Insurance, Health; Japan; Logistic Models; Male; Methotrexate; Risk; Surveys and Questionnaires | 2015 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Kidney Diseases; Male; Methotrexate; Pentoxifylline; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2015 |
Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Female; Glutathione; Interleukin-1beta; Liver; Male; Malondialdehyde; Methotrexate; Necrosis; Peroxidase; Random Allocation; Rats, Wistar; Reproducibility of Results; Thioctic Acid; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Liver steatosis is a risk factor for hepatotoxicity in patients with inflammatory bowel disease under immunosuppressive treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Azathioprine; Body Mass Index; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn Disease; Fatty Liver; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors; Ultrasonography; Young Adult | 2015 |
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Etanercept; Female; Hepatitis C, Chronic; Humans; Hydroxychloroquine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
All-trans retinoic acid mitigates methotrexate-induced liver injury in rats; relevance of retinoic acid signaling pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Down-Regulation; Immunosuppressive Agents; Keratolytic Agents; Male; Methotrexate; Rats; Rats, Sprague-Dawley; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoid X Receptor alpha; Signal Transduction; Tretinoin | 2015 |
Significance of liver biopsy for the evaluation of methotrexate-induced liver damage in patients with rheumatoid arthritis.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Methotrexate; Severity of Illness Index | 2015 |
Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress.
Topics: Animals; Chemical and Drug Induced Liver Injury; Curcuma; Liver; Male; Methotrexate; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Wistar | 2015 |
Reduction of oxidative stress by an ethanolic extract of leaves of Piper betle (Paan) Linn. decreased methotrexate-induced toxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Methotrexate; Oxidative Stress; Piper betle; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2015 |
Rutin ameliorates methotrexate induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Glutathione Peroxidase; Immunosuppressive Agents; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Rats, Wistar; Reproducibility of Results; Rutin; Superoxide Dismutase | 2015 |
Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies; Taiwan | 2016 |
Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: impact of oxidative stress, inflammation and apoptosis.
Topics: Animals; Apoptosis; Benzimidazoles; Benzoates; Captopril; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Immunohistochemistry; Liver Function Tests; Male; Methotrexate; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Telmisartan | 2016 |
Methotrexate efficacy, but not its intolerance, is associated with the dose and route of administration.
Topics: Abdominal Pain; Administration, Oral; Anemia; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Psoriatic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Injections, Subcutaneous; Kaplan-Meier Estimate; Male; Methotrexate; Nausea; Oral Ulcer; Prospective Studies; Treatment Outcome; Vomiting | 2016 |
British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease 2016.
Topics: Adult; Alcohol Drinking; Biological Products; Bone Marrow Diseases; Checklist; Chemical and Drug Induced Liver Injury; Chickenpox; Child; Counseling; Cyclosporine; Dermatologic Agents; Drug Administration Routes; Drug Administration Schedule; Drug Approval; Drug Interactions; Drug Monitoring; Drug Overdose; Evidence-Based Medicine; Female; Hepatitis, Viral, Human; HIV Infections; Humans; Intraoperative Complications; Kidney Diseases; Lung Diseases; Methotrexate; Nausea; Neoplasms; Off-Label Use; Patient Education as Topic; Patient Safety; Pregnancy; Pregnancy Complications; Retinoids; Skin Diseases; Tuberculosis; Ultraviolet Rays; Vaccination | 2016 |
Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.
Topics: Biomarkers; Bioprinting; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Collagen; Cytokines; Dose-Response Relationship, Drug; Endothelial Cells; Feasibility Studies; Gene Expression Regulation; Hepatic Stellate Cells; Hepatocytes; Humans; Liver; Liver Cirrhosis; Methotrexate; Phenotype; Printing, Three-Dimensional; Risk Assessment; Thioacetamide; Time Factors | 2016 |
Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting.
Topics: Adult; Age Factors; Chemical and Drug Induced Liver Injury; Child; Consensus; Denmark; Dermatology; Drug Dosage Calculations; Female; Humans; Immunosuppressive Agents; Liver Function Tests; Male; Methotrexate; Neoplasms; Patient Safety; Pregnancy; Pregnancy Complications; Psoriasis; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2017 |
Effectiveness and safety of Methotrexate in psoriasis: an eight-year experience with 218 patients.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Treatment Outcome | 2017 |
Hepatotoxicity During Maintenance Therapy and Prognosis in Children With Acute Lymphoblastic Leukemia.
Topics: Adolescent; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2017 |
Diagnostic performance of transient elastography for detection of methotrexate-induced liver injury using Roenigk classification in Asian patients with psoriasis: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies | 2017 |
Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; gamma-Glutamyl Hydrolase; Gastrointestinal Diseases; Haplotypes; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Nucleotide Deaminases; Peptide Synthases; Polymorphism, Single Nucleotide; Psoriasis; Treatment Outcome | 2009 |
Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Cohort Studies; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Young Adult | 2010 |
Severe hepatotoxicity in a patient on bosentan upon addition of methotrexate: reversible with resumption of methotrexate without bosentan.
Topics: Antihypertensive Agents; Bosentan; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Interactions; Female; Humans; Hypertension, Pulmonary; Methotrexate; Middle Aged; Polypharmacy; Scleroderma, Systemic; Sulfonamides | 2009 |
Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Gastrointestinal Diseases; Hospitals, Teaching; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Liver; Male; Methotrexate; Middle Aged; New South Wales; Practice Guidelines as Topic; Remission Induction; Retrospective Studies; Rheumatology; Young Adult | 2009 |
Hepatotoxicity rates do not differ in patients with rheumatoid arthritis and psoriasis treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors | 2009 |
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Tetrahydrofolate Dehydrogenase; Young Adult | 2009 |
Hepatoprotective effect of tumour necrosis factor alpha blockade in psoriatic arthritis: a cross-sectional study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cross-Sectional Studies; Drug Evaluation; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prospective Studies; Tumor Necrosis Factor-alpha | 2010 |
Comment on: Hepatotoxicity rates do not differ in patients with rheumatoid arthritis and psoriasis treated with methotrexate.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Methotrexate; Research Design | 2010 |
[Hepatotoxicity induced by new immunosuppressants].
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Methotrexate; Tumor Necrosis Factor-alpha | 2010 |
Daily practice assessment of liver injury in patients with psoriasis on methotrexate.
Topics: Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Collagen Type III; Dermatologic Agents; Female; Humans; Male; Methotrexate; Middle Aged; Peptide Fragments; Psoriasis | 2010 |
Monitoring methotrexate toxicity in juvenile idiopathic arthritis.
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Child; Databases, Factual; Drug Monitoring; Female; Humans; Liver; Male; Methotrexate; Risk Factors | 2009 |
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.
Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Stomatitis; Vincristine | 2010 |
Changes in liver biochemistry during methotrexate use for inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Female; Humans; Inflammatory Bowel Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors | 2010 |
Protective effect of beta-carotene on methotrexate-induced oxidative liver damage.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; beta Carotene; Chemical and Drug Induced Liver Injury; Glutathione Peroxidase; Histocytochemistry; Lipid Peroxidation; Liver; Malondialdehyde; Methotrexate; Microscopy; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase | 2010 |
Risk of elevated liver enzymes associated with TNF inhibitor utilisation in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Alanine Transaminase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epidemiologic Methods; Etanercept; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Liver Function Tests; Male; Methotrexate; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2010 |
Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes.
Topics: Antirheumatic Agents; Arthritis, Psoriatic; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Autoimmune; Humans; Incidence; Liver; Male; Methotrexate; Middle Aged; Risk Factors; Transaminases | 2010 |
Resveratrol protects against methotrexate-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Antimetabolites, Antineoplastic; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Resveratrol; Stilbenes; Tumor Necrosis Factor-alpha | 2010 |
[Guidelines on the use of methotrexate in psoriasis].
Topics: Chemical and Drug Induced Liver Injury; Humans; Immunosuppressive Agents; Methotrexate; Psoriasis; Records | 2010 |
[Methotrexate toxicity. Myths and facts].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Evidence-Based Medicine; Humans; Methotrexate; Pneumonia; Risk Assessment | 2011 |
[A case of the association of acute lymphoblastic lymphoma with active tuberculosis in the child: a Malian case].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Cytarabine; Humans; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Tuberculosis, Pulmonary; Vincristine | 2010 |
[Evaluation of liver fibrosis by non-invasive methods].
Topics: Chemical and Drug Induced Liver Injury; Elasticity Imaging Techniques; Female; Humans; Immunosuppressive Agents; Liver Cirrhosis; Male; Methotrexate | 2011 |
Caffeic acid phenethyl ester (CAPE) prevents methotrexate-induced hepatorenal oxidative injury in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Caffeic Acids; Chemical and Drug Induced Liver Injury; Female; Glutathione; Interleukin-1beta; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tumor Necrosis Factor-alpha | 2011 |
Autoimmune hepatitis after long-term methotrexate therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Chemical and Drug Induced Liver Injury; Glucocorticoids; Hepatitis, Autoimmune; Humans; Immunoglobulin G; Male; Methotrexate; Middle Aged | 2011 |
Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Discriminant Analysis; Liver; Male; Mass Spectrometry; Metabolome; Metabolomics; Methotrexate; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Steroids | 2012 |
[Methotrexate].
Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Interactions; Drug Monitoring; Humans; Lung Diseases; Methotrexate; Pancytopenia; Psoriasis; Skin Neoplasms | 2011 |
[Patient education. Information letter on treatment of psoriasis with methotrexate].
Topics: Anemia; Chemical and Drug Induced Liver Injury; Cough; Dermatologic Agents; Drug Interactions; Fever; Humans; Methotrexate; Nausea; Psoriasis | 2011 |
Methotrexate therapy, rheumatoid arthritis, and life-threatening liver complications: should we be monitoring more closely?
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Methotrexate; Withholding Treatment | 2012 |
Role of routine monitoring of liver and renal function during treatment of ectopic pregnancies with single-dose methotrexate protocol.
Topics: Abortifacient Agents, Nonsteroidal; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Diagnostic Tests, Routine; Dose-Response Relationship, Drug; Female; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Liver; Liver Function Tests; Methotrexate; Middle Aged; Monitoring, Physiologic; Predictive Value of Tests; Pregnancy; Pregnancy, Ectopic; Retrospective Studies; Young Adult | 2012 |
Beneficial effects of montelukast against methotrexate-induced liver toxicity: a biochemical and histological study.
Topics: Acetates; Animals; Chemical and Drug Induced Liver Injury; Cyclopropanes; Drug Evaluation, Preclinical; Female; Glutathione; Glycogen; Hepatocytes; Liver; Malondialdehyde; Methotrexate; Oxidative Stress; Periodic Acid-Schiff Reaction; Peroxidase; Quinolines; Rats; Rats, Wistar; Sulfides | 2012 |
Folinic acid administration after MTX GVHD prophylaxis in pediatric allo-SCT.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclosporine; Drug Monitoring; Drug Therapy, Combination; Female; Folic Acid Antagonists; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infant; Leucovorin; Male; Methotrexate; Mucositis; Retrospective Studies; Severity of Illness Index; Stem Cell Transplantation; Survival Analysis; Transplantation, Homologous; Vitamin B Complex | 2013 |
[Liver diseases in rheumatoid and psoriatic arthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cohort Studies; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Methotrexate; Middle Aged; Obesity; Risk Factors | 2012 |
Tumour necrosis factor-alpha inhibitor-induced hepatic injury in patients with rheumatoid arthritis: two case reports and an analysis of the laboratory data from the Slovenian national biologicals registry.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Methylprednisolone; Registries; Slovenia; Sulfasalazine; Tumor Necrosis Factor-alpha | 2013 |
Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats.
Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Clarithromycin; Diarrhea; Gastrointestinal Transit; Glutathione; Ileum; Inflammation; Intestinal Diseases; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methotrexate; Neutrophil Infiltration; Oxidative Stress; Peroxidase; Probiotics; Rats; Rats, Sprague-Dawley; Saccharomyces | 2013 |
Short-term methotrexate therapy in psoriasis: a study of 197 patients.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dermatologic Agents; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Psoriasis; Retrospective Studies; Severity of Illness Index; Time Factors | 2002 |
Hepatotoxicity in patients with juvenile idiopathic arthritis receiving longterm methotrexate therapy.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Biopsy; Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Combination; Female; Humans; Liver; Male; Methotrexate; Time Factors | 2002 |
Role of liver function tests in detecting methotrexate-induced liver damage in sarcoidosis.
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Sarcoidosis | 2003 |
METHOTREXATE-INDUCED HEPATIC INJURY IN AN ADULT. A CASE REPORT.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Child; Hepatitis; Humans; Leukemia; Leukopenia; Methotrexate; Pathology; Psoriasis; Toxicology | 1964 |
High incidence of hepatotoxicity of isoniazid treatment for tuberculosis chemoprophylaxis in patients with rheumatoid arthritis treated with methotrexate or sulfasalazine and anti-tumour necrosis factor inhibitors.
Topics: Adult; Aged; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoniazid; Methotrexate; Middle Aged; Sulfasalazine; Tuberculosis; Tumor Necrosis Factor-alpha | 2003 |
Optimal management of methotrexate intoxication in a child with osteosarcoma.
Topics: Acute Kidney Injury; Adolescent; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Humans; Male; Methotrexate; Mouth Mucosa; Osteosarcoma; Stomatitis | 2004 |
Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.
Topics: Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Activation; Female; Humans; Liver; Liver Function Tests; Male; Maximum Tolerated Dose; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Probability; Risk Assessment; Severity of Illness Index | 2004 |
Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Female; Follow-Up Studies; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Risk Assessment; Treatment Failure | 2005 |
Analysis of risk factors in psoriatic patients with methotrexate-induced increases in transaminase levels.
Topics: Adult; Age Factors; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Psoriasis; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Transaminases | 2004 |
Noninvasive monitoring for methotrexate hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Monitoring; Humans; Methotrexate; Psoriasis | 2005 |
Replacement of routine liver biopsy by procollagen III aminopeptide for monitoring patients with psoriasis receiving long-term methotrexate: a multicentre audit and health economic analysis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Drug Administration Schedule; Drug Monitoring; Female; Health Care Costs; Humans; Liver Diseases; Male; Medical Audit; Methotrexate; Middle Aged; Patient Satisfaction; Peptide Fragments; Practice Guidelines as Topic; Procollagen; Psoriasis | 2005 |
Severe hepatotoxicity in a rheumatoid arthritis patient switched from leflunomide to methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Isoxazoles; Leflunomide; Methotrexate; Severity of Illness Index | 2005 |
Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Erythrocytes; Female; Humans; Liver Cirrhosis; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Statistics, Nonparametric | 2006 |
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genetic Variation; Hematologic Diseases; Humans; Infant; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis | 2006 |
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.
Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Daunorubicin; Developing Countries; Disease-Free Survival; Drug Evaluation; Etoposide; Female; Gastrointestinal Diseases; Heart Diseases; Hematologic Diseases; Humans; Infant; Infections; Kaplan-Meier Estimate; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Prednisone; Remission Induction; Retrospective Studies; Singapore; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine | 2007 |
[Infliximab-induced hepatitis in a patient with Crohn's disease].
Topics: Acute Disease; Adult; Antibodies, Monoclonal; Azathioprine; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Crohn Disease; Female; Humans; Immunosuppressive Agents; Infliximab; Leukapheresis; Mesalamine; Methotrexate; Pancreatitis; Prednisone; Rectovaginal Fistula | 2006 |
N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Methotrexate; Oxidants; Oxidative Stress; Rats; Rats, Wistar | 2006 |
Can dantrolene contribute to methotrexate toxicity?
Topics: Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Dantrolene; Drug Interactions; Female; Humans; Methotrexate; Mucositis; Thrombocytopenia | 2006 |
Liver injury in long-term methotrexate treatment in psoriasis is relatively infrequent.
Topics: Chemical and Drug Induced Liver Injury; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk Factors; Treatment Outcome; Withholding Treatment | 2006 |
The contribution of methotrexate exposure and host factors on transcriptional variance in human liver.
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Cluster Analysis; Complement Activation; Female; Folic Acid Antagonists; Gene Expression Regulation; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Molecular Sequence Data; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction; Rheumatic Diseases; RNA | 2007 |
Reconsidering liver biopsies during methotrexate therapy.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Humans; Liver; Methotrexate; Practice Guidelines as Topic | 2007 |
Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Doxorubicin; Female; Genotype; Hematologic Diseases; Humans; Kaplan-Meier Estimate; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mucositis; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prednisone; Risk; Survival Analysis; Treatment Outcome; Vincristine | 2007 |
Methotrexate combined with isoniazid treatment for latent tuberculosis is well tolerated in patients with rheumatoid arthritis: experience from an urban arthritis clinic.
Topics: Adult; Antirheumatic Agents; Antitubercular Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Humans; Immunosuppressive Agents; Isoniazid; Liver Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Secondary Prevention; Tuberculosis; Tumor Necrosis Factor-alpha; Urban Health | 2008 |
Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Immunosuppressive Agents; Lipid Peroxidation; Liver Diseases; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Ursodeoxycholic Acid | 2008 |
[Serum liver tests in patients treated with methotrexate. A retrospective analysis].
Topics: Acute Disease; Biomarkers; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Dermatologic Agents; Female; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Psoriasis; Retrospective Studies; Transaminases | 2007 |
Reliability of the Roenigk classification of liver damage after methotrexate treatment for psoriasis: a clinicopathologic study of 160 liver biopsy specimens.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Dermatologic Agents; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Psoriasis; Reproducibility of Results; Retrospective Studies; Severity of Illness Index; Single-Blind Method | 2007 |
Efficacy and tolerability of high-dose methotrexate in central nervous system positive or relapsed lymphoproliferative disease following liver transplant in children.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Liver Transplantation; Lymphoma, Non-Hodgkin; Male; Methotrexate; Postoperative Complications; Tomography, X-Ray Computed | 2008 |
Epstein Barr virus-induced hepatitis associated with methotrexate treatment.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Epstein-Barr Virus Infections; Female; Hepatitis, Viral, Human; Humans; Immunosuppressive Agents; Liver Function Tests; Lupus Erythematosus, Cutaneous; Methotrexate; Middle Aged; Serologic Tests | 2008 |
Concurrent use of methotrexate and acitretin revisited.
Topics: Acitretin; Adolescent; Adult; Aged; Alcohol Drinking; Alopecia; Chemical and Drug Induced Liver Injury; Child; Contraindications; Dermatologic Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Treatment Outcome | 2008 |
[Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report].
Topics: Adalimumab; Adolescent; Alanine Transaminase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Aspartate Aminotransferases; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Cortisone; Diagnosis, Differential; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Isoxazoles; Leflunomide; Liver; Liver Function Tests; Methotrexate; Prednisolone | 2008 |
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting | 2008 |
Methotrexate for psoriasis.
Topics: Abnormalities, Drug-Induced; Chemical and Drug Induced Liver Injury; Female; Humans; Leukemia; Methotrexate; Peptic Ulcer; Pregnancy; Pregnancy Complications; Psoriasis | 1967 |
Modified triple chemotherapy in the management of high-risk metastatic gestational trophoblastic tumors.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Cisplatin; Cyclophosphamide; Dactinomycin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Pregnancy Complications, Neoplastic; Risk; Thrombocytopenia; Trophoblastic Neoplasms; Uterine Neoplasms; Vinblastine | 1984 |
Methotrexate with citrovorum factor rescue as primary therapy for gestational trophoblastic disease.
Topics: Adolescent; Adult; Agranulocytosis; Chemical and Drug Induced Liver Injury; Dactinomycin; Drug Therapy, Combination; Female; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Thrombocytopenia; Trophoblastic Neoplasms; Uterine Neoplasms | 1982 |
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Survival; Chemical and Drug Induced Liver Injury; Ethanol; Fentanyl; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Methotrexate; Oxytetracycline; Protein Biosynthesis; Rats; Valine | 1984 |
[Long-term toxicity of anti-leukemia therapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Infertility; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Radiotherapy | 1983 |
Prolonged methotrexate infusions in children with acute leukemia in relapse and in remission and with medulloblastoma. Pharmacokinetics, toxicity and clinical results.
Topics: Actuarial Analysis; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Hematologic Diseases; Humans; Infusions, Parenteral; Injections, Spinal; Kinetics; Leukemia, Lymphoid; Medulloblastoma; Methotrexate; Recurrence | 1984 |
High-dose methotrexate for osteosarcoma: toxicity and clinical results.
Topics: Adolescent; Adult; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Mucous Membrane; Osteosarcoma | 1983 |
Phase II and pharmacokinetic study of high-dose methotrexate in the treatment of advanced gynecologic malignancy. A Southwest Oncology Group Trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Genital Neoplasms, Female; Hematologic Diseases; Humans; Kidney Diseases; Kinetics; Leucovorin; Methotrexate; Middle Aged; Nausea; Time Factors | 1984 |
Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Liver Function Tests; Methotrexate; Middle Aged; Psoriasis; Tretinoin | 1983 |
Methotrexate therapy in rheumatoid arthritis: 15 years experience.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Injections, Intramuscular; Liver; Liver Diseases; Methotrexate; Middle Aged | 1983 |
Methotrexate and etretinate as concurrent therapies in the treatment of psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Etretinate; Female; Humans; Methotrexate; Middle Aged; Psoriasis | 1984 |
[Damage to liver and biliary tracts by long-term drug therapy (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis, Intrahepatic; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Female; Humans; Isoniazid; Jaundice; Liver Cirrhosis; Male; Methotrexate | 1980 |
Assessment of liver function using fasting bile salt concentrations in psoriasis prior to and during methotrexate therapy.
Topics: Adult; Aged; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Fasting; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis | 1983 |
Liver damage in children with acute leukaemia and non-Hodgkin's lymphoma on oral maintenance chemotherapy.
Topics: Adolescent; Alkaline Phosphatase; Antineoplastic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Lymphoma; Male; Methotrexate; Time Factors | 1980 |
Life-threatening neuropathy and hepatotoxicity in infants during induction therapy for acute lymphoblastic leukemia.
Topics: Asparaginase; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Retrospective Studies; Vincristine | 1981 |
Methotrexate: a perspective of its use in the treatment of rheumatic diseases.
Topics: Arthritis, Rheumatoid; Blood Sedimentation; Chemical and Drug Induced Liver Injury; Female; Gastrointestinal Diseases; Humans; Liver Function Tests; Male; Methotrexate | 1982 |
Liver biopsies upsilon liver scans in methotrexate-treated patients with psoriasis.
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Radionuclide Imaging; Retrospective Studies | 1982 |
Liver biopsies in patients on methotrexate for the treatment of psoriasis.
Topics: Biopsy, Needle; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Psoriasis | 1980 |
Liver biopsies in psoriatics--complications and evaluation.
Topics: Adult; Aged; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Pneumothorax; Psoriasis | 1980 |
Razoxane in the treatment of psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Piperazines; Psoriasis; Razoxane | 1980 |
Usefulness of the American College of Rheumatology recommendations for liver biopsy in methotrexate-treated rheumatoid arthritis patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost Savings; Diabetes Mellitus, Type 1; Drug Monitoring; Evaluation Studies as Topic; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Rheumatology; Risk Factors; United States | 1995 |
[Effects of drugs on the liver. A review illustrated with 3 clinical cases].
Topics: Acetaminophen; Adult; Aged; Androgens; Chemical and Drug Induced Liver Injury; Denmark; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Humans; Male; Methotrexate; Middle Aged; Sulfamethizole | 1994 |
Assessing the preferences of patients with psoriasis. A quantitative, utility approach.
Topics: Adult; Aged; Attitude to Health; Biopsy; Chemical and Drug Induced Liver Injury; Decision Making; Female; Forecasting; Health Status; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Patient Satisfaction; Psoriasis; Quality of Life; Time Factors; Treatment Outcome | 1995 |
Creating a care-effective cost-effective strategy for methotrexate liver toxicity monitoring in rheumatoid arthritis: comment on the article by Kremer et al.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Delivery of Health Care; Humans; Liver Diseases; Methotrexate | 1995 |
Monitoring patients taking methotrexate.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Drug Monitoring; Humans; Liver; Liver Diseases; Methotrexate; Serum Albumin | 1995 |
Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Azasteroids; Blood Glucose; Chemical and Drug Induced Liver Injury; Chlorambucil; Cholesterol; Cisplatin; Epirubicin; gamma-Glutamyltransferase; Kidney; Kidney Diseases; Liver Diseases; Male; Methotrexate; Nitrogen; Nitrogen Mustard Compounds; Potassium; Rats; Rats, Wistar; Sodium; Weight Loss | 1993 |
Suggested guidelines for monitoring liver toxicity in rheumatoid arthritis patients treated with methotrexate: comment on the article by Kremer et al.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Practice Guidelines as Topic | 1994 |
Acute urticaria and hepatitis complicating high-dose methotrexate therapy.
Topics: Acute Disease; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Humans; Methotrexate; Osteosarcoma; Urticaria | 1995 |
Methotrexate revisited: effects of long-term treatment in psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1994 |
Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology.
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Humans; Liver; Liver Diseases; Liver Function Tests; Methotrexate; Risk Factors | 1994 |
Liver function studies in children with acute lymphocytic leukemia after cessation of therapy.
Topics: Adolescent; Adult; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Child; Daunorubicin; Follow-Up Studies; Humans; Liver; Mercaptopurine; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1994 |
The value of dynamic hepatic scintigraphy and serum aminoterminal propeptide of type III procollagen for early detection of methotrexate-induced hepatic damage in psoriasis patients.
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Immunosuppressive Agents; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Peptide Fragments; Procollagen; Prospective Studies; Psoriasis; Radionuclide Imaging | 1996 |
Reversible cutaneous lymphoma occurring during methotrexate therapy.
Topics: Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Follow-Up Studies; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Neoplasm Regression, Spontaneous; Skin Neoplasms | 1996 |
[Untoward effects of low dose methotrexate therapy in rheumatoid arthritis].
Topics: Adult; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cough; Drug Eruptions; Female; Headache; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Middle Aged; Retrospective Studies | 1996 |
[Adverse effects of low-dose methotrexate therapy in rheumatoid arthritis].
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cough; Drug Administration Schedule; Drug Eruptions; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nausea; Retrospective Studies | 1996 |
Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Liver Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transaminases; Treatment Outcome | 1997 |
Re: J.M. Kremer--editorial.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Practice Guidelines as Topic | 1997 |
Monitoring for methotrexate hepatotoxicity in patients with rheumatoid arthritis: another hepatologist's perspective.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Contraindications; Drug Monitoring; Humans; Liver; Liver Function Tests; Methotrexate; Practice Guidelines as Topic | 1997 |
The long-term effect of methotrexate therapy on the liver in patients with juvenile rheumatoid arthritis.
Topics: Adolescent; Adult; Alanine Transaminase; Alcohol Drinking; Antirheumatic Agents; Arthritis, Juvenile; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Child; Female; Fibrosis; Humans; Liver; Male; Methotrexate; Serum Albumin | 1997 |
Comparison of chemotherapies with methotrexate, VP-16 and actinomycin-D in low-risk gestational trophoblastic disease. Remission rates and drug toxicities.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Dactinomycin; Drug Administration Schedule; Etoposide; Female; Hematologic Diseases; Humans; Methotrexate; Pregnancy; Remission Induction; Risk Factors; Trophoblastic Neoplasms; Uterine Neoplasms | 1998 |
[Hypertransaminemia and methotrexate: not always a toxic effect?].
Topics: Adult; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Methotrexate; Retrospective Studies; Rheumatic Diseases; Transaminases | 1998 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Liver Diseases; Male; Methionine; Methotrexate; Mice; Mice, Inbred DBA; Niacinamide | 1999 |
The extended oligoarticular subtype is the best predictor of methotrexate efficacy in juvenile idiopathic arthritis.
Topics: Adolescent; Age of Onset; Analysis of Variance; Antirheumatic Agents; Arthritis, Juvenile; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Monitoring; Female; Gastrointestinal Diseases; Humans; Infant; Logistic Models; Male; Methotrexate; Predictive Value of Tests; Recurrence; Remission Induction; Treatment Outcome | 1999 |
Hepatic toxicity from cyclophosphamide, methotrexate, fluorouracil (CMF regimen)
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Humans; Liver; Liver Function Tests; Methotrexate; Retrospective Studies; Risk Assessment | 1999 |
Accidental methotrexate overdose.
Topics: Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Folic Acid; Hemorrhage; Humans; Methotrexate; Middle Aged | 1999 |
Toxicity of high-dose sequential chemotherapy and purged autologous hematopoietic cell transplantation precludes its use in refractory/recurrent non-Hodgkin's lymphoma.
Topics: Acute Kidney Injury; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Purging; Cardiomyopathies; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Cyclophosphamide; Cystitis; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hemorrhage; Humans; Infections; Leucovorin; Life Tables; Lymphoma, Non-Hodgkin; Male; Melphalan; Methotrexate; Middle Aged; Mitoxantrone; Pilot Projects; Salvage Therapy; Survival Analysis; Survival Rate; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Vincristine | 2000 |
Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn Disease; Female; Folic Acid Antagonists; Humans; Liver; Male; Methotrexate; Time Factors | 2000 |
Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection.
Topics: Antimetabolites, Antineoplastic; Case-Control Studies; Chemical and Drug Induced Liver Injury; Child; Egypt; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Incidence; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Saudi Arabia | 2001 |
Liver biopsies and methotrexate: a time for reconsideration?
Topics: Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Practice Guidelines as Topic; Psoriasis | 2001 |
Methotrexate poisoning with acute hepatorenal dysfunction.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Female; Hemofiltration; Humans; Liver Diseases; Methotrexate; Osteosarcoma; Plasma Exchange; Renal Dialysis; Treatment Outcome | 2001 |
Is there a place for leflunomide in the treatment of rheumatoid arthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Isoxazoles; Leflunomide; Methotrexate; Randomized Controlled Trials as Topic | 2001 |
Liver biopsy in methotrexate-treated psoriatics-a re-evalution.
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Child; Ethanol; Female; Follow-Up Studies; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis | 1975 |
The relation of HL-A antigens to liver histology in methotrexate-treated psoriatics.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Histocompatibility Antigens; HLA Antigens; Humans; Liver; Male; Methotrexate; Middle Aged; Psoriasis | 1976 |
[Practical aspects of the cytostatic therapy of psoriasis].
Topics: Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis; Time Factors | 1976 |
Methotrexate with citrovorum factor rescue for gestational trophoblastic neoplasms.
Topics: Adolescent; Adult; Bone Marrow; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Drug Therapy, Combination; Epithelium; Female; Humans; Leucovorin; Liver; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Pregnancy Complications; Remission, Spontaneous; Trophoblastic Neoplasms; Uterine Neoplasms | 1978 |
Methotrexate with citrovorum factor rescue for nonmetastatic gestational trophoblastic neoplasms.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Chorionic Gonadotropin; Drug Administration Schedule; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Leucovorin; Liver; Methotrexate; Middle Aged; Pregnancy; Risk; Trophoblastic Neoplasms; Uterine Neoplasms | 1979 |
[Liver injury during combined chemotherapy of acute leukemias].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Humans; Leukemia; Mercaptopurine; Methotrexate; Vincristine | 1979 |
[Evaluation of hepatic function during maintenance therapy of acute lymphoblastic leukemia remission in children].
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Liver; Liver Function Tests; Mercaptopurine; Methotrexate; Remission, Spontaneous | 1977 |
Hepatotoxicity in the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Child; Humans; Leukemia, Lymphoid; Liver Diseases; Liver Function Tests; Mercaptopurine; Methotrexate | 1979 |
Enzymatic fluorometry for estimating serum total bile acid concentration.
Topics: 3-Hydroxysteroid Dehydrogenases; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Fasting; Fatty Liver; Female; Fluorometry; Hepatitis, Viral, Human; Humans; Liver; Liver Diseases; Male; Methotrexate; Necrosis; Sarcoidosis | 1979 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Animals; Chemical and Drug Induced Liver Injury; Chronic Disease; Contraceptives, Oral; Drug Hypersensitivity; Female; Halothane; Humans; Isoniazid; Liver; Liver Neoplasms; Methotrexate; Pharmaceutical Preparations; Tetracycline | 1979 |
[Hepatic tolerance of methotrexate].
Topics: Cell Membrane Permeability; Chemical and Drug Induced Liver Injury; Humans; Methotrexate | 1979 |
Liver ultrastructure in psoriatics related to methotrexate therapy. 1. A prospective study of findings in hepatocytes from 24 patients before and after methotrexate treatment.
Topics: Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasm; Endoplasmic Reticulum; Golgi Apparatus; Humans; Liver; Lysosomes; Methotrexate; Mitochondria, Liver; Prospective Studies; Psoriasis | 1977 |
Liver ultrastructure in psoriatics related to methotrexate therapy. 2. Findings in bile ducts from 11 methotrexate treated psoriatics and 2 controls.
Topics: Adult; Aged; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Female; Golgi Apparatus; Humans; Liver; Male; Methotrexate; Microvilli; Middle Aged; Mitochondria; Psoriasis | 1977 |
Drugs and what they do to the liver.
Topics: Adrenal Cortex Hormones; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Pyrrolizidine Alkaloids; Tetracycline; Vitamin A | 1978 |
Fine structural changes in the liver of methotrexate-treated psoriatics.
Topics: Adult; Aged; Alcohol Drinking; Cell Membrane; Cell Nucleus; Chemical and Drug Induced Liver Injury; Desmosomes; Endoplasmic Reticulum; Female; Golgi Apparatus; Humans; Hyperplasia; Liver; Male; Methotrexate; Middle Aged; Mitochondria, Liver; Psoriasis; Time Factors | 1978 |
Choline antagonism of methotrexate liver toxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Hydroxyurea; Liver; Liver Diseases; Male; Methotrexate; Methylation; Rats; Triglycerides | 1977 |
Methotrexate hepatotoxicity in children with leukemia.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Liver; Liver Cirrhosis; Methotrexate; Transaminases | 1977 |
Systemic chemotherapy for psoriasis: a national survey.
Topics: Adult; Azauridine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Utilization; Female; Humans; Hydroxyurea; Liver; Methotrexate; Neoplasms; Psoriasis; Thrombophlebitis | 1976 |
Letter: Liver disease in psoriatics.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1975 |
Liver disease caused by medicinal agents.
Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptive Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Halothane; Humans; Isoniazid; Jaundice; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Methotrexate; Methoxyflurane; Methyldopa; Necrosis; Novobiocin | 1975 |
Azaribine therapy for psoriasis. Evaluation of potential effects on the liver and other organ systems.
Topics: Adolescent; Adult; Azauridine; Biopsy; Brain; Cardiovascular System; Chemical and Drug Induced Liver Injury; Digestive System; Female; Hematopoietic System; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis | 1975 |
[Dynamics of some indices of interstitial metabolism in patients with psoriasis during treatment with methotrexate].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Evaluation; Female; Fructose-Bisphosphate Aldolase; Humans; Liver; Male; Methotrexate; Middle Aged; Minerals; Proteins; Psoriasis; Transaminases | 1975 |
Letter: Treatment of dermatomyositis.
Topics: Chemical and Drug Induced Liver Injury; Dermatomyositis; Humans; Methotrexate | 1976 |
Liver disease, erroneously attributed to methotrexate, in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Diagnostic Errors; Felty Syndrome; Humans; Male; Methotrexate | 1992 |
Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Child; Female; Follow-Up Studies; Humans; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis | 1992 |
Fulminant hepatic failure in non-Hodgkin lymphoma patients treated with chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Doxorubicin; Female; Hepatitis B; Humans; Immunocompromised Host; Liver Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisolone; Prednisone; Vincristine | 1992 |
Massive intrahepatic hemorrhage following routine liver biopsy in a patient with rheumatoid arthritis treated with methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Liver; Liver Diseases; Methotrexate | 1992 |
Low-dose methotrexate therapy and hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate | 1992 |
Liver biopsies in patients with rheumatoid arthritis receiving methotrexate: where are we going?
Topics: Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate | 1992 |
Clinical liver disease in patients with rheumatoid arthritis taking methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Humans; Incidence; Liver; Liver Cirrhosis; Liver Diseases; Methotrexate; Middle Aged; Obesity; Pulmonary Fibrosis | 1992 |
Acute hepatotoxicity after high-dose methotrexate administration to rats.
Topics: Animals; Bile Acids and Salts; Biliary Tract; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Kidney; Male; Methotrexate; Rats; Rats, Inbred Strains; Transaminases | 1991 |
[Severe methotrexate poisoning].
Topics: Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Enteritis; Femoral Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Poisoning; Pulmonary Fibrosis | 1991 |
Two methods of assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Collagen; Female; Histological Techniques; Humans; Image Interpretation, Computer-Assisted; Liver; Male; Methotrexate; Middle Aged | 1991 |
Low-dose methotrexate therapy and hepatotoxicity. The view of the hepatologist.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1991 |
[Fulminant hepatic failure induced by intermediate dose methotrexate in a case of non-Hodgkin's lymphoma].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate | 1990 |
Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Liver Diseases; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transaminases | 1990 |
Treatment of advanced stage mycosis fungoides with bleomycin, doxorubicin, and methotrexate with topical nitrogen mustard (BAM-M).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chemical and Drug Induced Liver Injury; Doxorubicin; Female; Humans; Lymphatic Metastasis; Male; Mechlorethamine; Methotrexate; Middle Aged; Mycosis Fungoides; Neutropenia; Skin Diseases; Skin Neoplasms; Splenectomy | 1986 |
Revised guidelines on methotrexate use and liver biopsy.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Methotrexate; Time Factors | 1989 |
Detection of hepatotoxicity associated with methotrexate therapy for psoriasis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholecystitis; Female; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Psoriasis; Retrospective Studies; Risk Factors; ROC Curve; Time Factors | 1989 |
Dangers of methotrexate/etretinate combination therapy.
Topics: Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Therapy, Combination; Etretinate; Humans; Male; Methotrexate; Middle Aged | 1988 |
Hepatitis in patients receiving intraarterial chemotherapy for metastatic colorectal carcinoma.
Topics: Bilirubin; Carcinoma; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Female; Floxuridine; Hepatic Artery; Hepatitis; Humans; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Rectal Neoplasms; Transaminases | 1987 |
Methotrexate in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Eruptions; Gastrointestinal Diseases; Humans; Immunosuppressive Agents; Lung Diseases; Methotrexate; Stomatitis; Teratogens | 1988 |
Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Peptic Ulcer; Prostheses and Implants; Rectal Neoplasms | 1985 |
Histopathologic findings in the liver of rheumatoid arthritis patients treated with long-term bolus methotrexate.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Time Factors | 1988 |
Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Collagen; Female; Humans; Liver; Liver Diseases; Lysosomes; Male; Methotrexate; Microscopy; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Prospective Studies | 1988 |
The use of antipyrine clearance to measure liver damage in psoriatic patients receiving methotrexate.
Topics: Adult; Antipyrine; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Psoriasis; Saliva | 1988 |
Dose-dependent acute hepatitis associated with administration of high dose methotrexate.
Topics: Acute Disease; Adolescent; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Humans; Methotrexate | 1988 |
A patient with methotrexate lung and granulomatous changes in the liver--or just sarcoidosis?
Topics: Blood Gas Analysis; Body Temperature; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Granuloma; Humans; Liver; Liver Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Radiography; Respiratory Function Tests; Sarcoidosis | 1988 |
Low dose pulse methotrexate in rheumatoid arthritis: an 8-year experience with hepatotoxicity.
Topics: Adult; Age Factors; Aged; Arthritis, Rheumatoid; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Retrospective Studies; Serum Albumin; Sex Factors; Transaminases | 1987 |
Diffuse hepatic uptake of technetium-99m methylene diphosphonate in a patient receiving high dose methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Liver Diseases; Methotrexate; Radionuclide Imaging; Technetium Tc 99m Medronate | 1987 |
The aminopyrine breath test, an inadequate early indicator of methotrexate-induced liver disease in patients with psoriasis.
Topics: Aminopyrine; Breath Tests; Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methotrexate; Psoriasis | 1987 |
Hepatotoxicity associated with low-dose, long-term methotrexate treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Time Factors | 1987 |
Methotrexate pharmacokinetics in psoriatic patients developing hepatic fibrosis.
Topics: Chemical and Drug Induced Liver Injury; Humans; Kinetics; Methotrexate; Psoriasis; Risk; Time Factors | 1986 |
Methotrexate therapy in rheumatoid arthritis. Current status.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Kinetics; Lung Diseases; Methotrexate | 1986 |
Liver biopsies from psoriatics treated with methotrexate.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Psoriasis | 1986 |
Long-term effects of etretinate on the liver in psoriasis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Etretinate; Female; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis | 1987 |
Methotrexate and the liver.
Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Necrosis; Serum Albumin; Transaminases | 1985 |
Remission induction of meningeal leukemia with high-dose intravenous methotrexate.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Parenteral; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Methotrexate; Neutropenia; Seizures; Stomatitis | 1985 |
Ultrasound as a screening procedure for methotrexate-induced hepatic damage in severe psoriasis.
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Ultrasonography | 1985 |
Oral methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1986 |
Low incidence of hepatotoxicity associated with long-term, low-dose oral methotrexate in treatment of refractory psoriasis, psoriatic arthritis, and rheumatoid arthritis. An acceptable risk/benefit ratio.
Topics: Adult; Aged; Alcohol Drinking; Arthritis; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Prospective Studies; Psoriasis | 1985 |
[Oral methotrexate therapy: pro and con].
Topics: Administration, Oral; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Humans; Methotrexate; Psoriasis; Risk | 1985 |
Predictive value of HLA antigen for methotrexate-induced liver damage in patients with psoriasis.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Histocompatibility Testing; HLA Antigens; Humans; Liver; Male; Methotrexate; Middle Aged; Psoriasis; Risk | 1985 |
Methotrexate maintenance therapy and liver damage in psoriasis.
Topics: Adult; Age Factors; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis | 1985 |
Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1985 |
Hepatotoxicity of prolonged methotrexate therapy for rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Diseases, Alcoholic; Liver Function Tests; Male; Methotrexate; Middle Aged; Sjogren's Syndrome | 1985 |
Low-dose methotrexate treatment of rheumatoid arthritis. Long-term observations.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Female; Follow-Up Studies; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Transaminases | 1985 |
[Liver damage due to cytostatic agents].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Dexamethasone; Humans; Liver; Liver Diseases; Male; Mercaptopurine; Methotrexate; Prednisone | 1985 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Hemolysis; Humans; Isoniazid; Kidney Diseases; Methotrexate; Pharmaceutical Preparations; Probability; Time Factors | 1985 |
Liver biopsy in methotrexate treatment.
Topics: Adult; Aged; Alanine Transaminase; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Necrosis; Pityriasis; Pityriasis Rubra Pilaris; Psoriasis | 1971 |
Cutaneous uses of the antiproliferative drugs.
Topics: Administration, Topical; Antimetabolites; Azauridine; Bleomycin; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Humans; Hydroxyurea; Immunotherapy; Melanoma; Methotrexate; Mitosis; Mycosis Fungoides; Organ Specificity; Psoriasis; Skin Neoplasms | 1974 |
The treatment of severe myasthenia gravis with immunosuppressive agents.
Topics: Adolescent; Adult; Age Factors; Agranulocytosis; Aminopterin; Azathioprine; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Dactinomycin; Drug Synergism; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Middle Aged; Myasthenia Gravis; Time Factors | 1969 |
[Liver biopsy studies in long-term therapy of psoriasis using methotrexate].
Topics: Adult; Aged; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Diseases; Long-Term Care; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1974 |
[Limitations and risks of therapy of psoriasis with amethopterin and hydroxyurea].
Topics: Adult; Aged; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Chromosome Disorders; Drug Eruptions; Female; Gastrointestinal Diseases; Hematopoietic System; Humans; Hydroxyurea; Male; Methotrexate; Middle Aged; Psoriasis; Pyelonephritis | 1971 |
The variability of individual tolerance to methotrexate in cancer patients.
Topics: Adult; Age Factors; Aged; Alopecia; Blood Urea Nitrogen; Body Weight; Chemical and Drug Induced Liver Injury; Conjunctivitis; Creatinine; Diarrhea; Drug Eruptions; Folic Acid; Humans; Injections, Intravenous; Leukopenia; Methotrexate; Middle Aged; Nausea; Neoplasms; Serum Albumin; Stomatitis; Thrombocytopenia; Time Factors; Vomiting | 1971 |
[Damage due to treatment of psoriasis with folic acid antagonists].
Topics: Anemia, Hypochromic; Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Chromosome Disorders; Drug Eruptions; Folic Acid Antagonists; Headache; Humans; Leucovorin; Methotrexate; Mouth Diseases; Mouth Mucosa; Nausea; Psoriasis; Vertigo | 1972 |
Infusion chemotherapy in hepatoma and metastatic liver tumors.
Topics: Adenocarcinoma; Adolescent; Aged; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Leucovorin; Liver Function Tests; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Neoplasm Metastasis; Rectal Neoplasms; Sigmoid Neoplasms | 1967 |
Liver disease in psoriatics--An effect of methotrexate therapy?
Topics: Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Biopsy; Cell Nucleus; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methods; Methotrexate; Mitochondria, Liver; Psoriasis; Sulfobromophthalein; Time Factors | 1974 |
Severe liver damage caused by treatment of psoriasis with methotrexate.
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Male; Methotrexate; Psoriasis | 1973 |
Intensive chemotherapy in children with acute lymphoblastic leukemia (L-2 protocol).
Topics: Administration, Oral; Adolescent; Age Factors; Antineoplastic Agents; Asparaginase; Carmustine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Hydroxyurea; Infant; Infections; Injections, Intravenous; Leukemia, Lymphoid; Male; Meningitis; Methotrexate; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1974 |
[Proceedings: Immunosuppression and treatment of psoriasis using cytostatic agents].
Topics: Aged; Antineoplastic Agents; Azathioprine; Bibliographies as Topic; Chemical and Drug Induced Liver Injury; Humans; Hydroxyurea; Immunosuppression Therapy; Male; Methotrexate; Psoriasis | 1973 |
[Incidence of liver diseases in psoriatic patients with special reference to methotrexate therapy].
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1973 |
Methrotrexate U.S.P. (amethopterin) and methotrexate sodium.
Topics: Abortion, Induced; Anemia; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Choriocarcinoma; Drug Interactions; Female; Humans; Leukemia; Leukopenia; Male; Methotrexate; Neoplasms; Pregnancy; Psoriasis; Skin Diseases; Testicular Neoplasms; Thrombocytopenia; Uric Acid; Uterine Neoplasms | 1973 |
[Liver of psoriatic patients treated with methotrexate].
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Psoriasis | 1973 |
Liver injury associated with methotrexate therapy for psoriasis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis; Methotrexate; Psoriasis; Time Factors | 1973 |
Hepatotoxicity of methotrexate in the treatment of psoriasis.
Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1973 |
Life-span carcinogenicity tests with 4-amino-N10-methylpteroylglutamic acid (methotrexate) in Swiss mice and Syrian golden hamsters.
Topics: Age Factors; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Cricetinae; Female; Liver; Liver Diseases; Lung Neoplasms; Lymphoma; Male; Methotrexate; Mice; Sex Factors; Species Specificity; Time Factors | 1973 |
Hepatotoxicity of long-term methotrexate therapy for psoriasis.
Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Drug Interactions; Ethanol; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Necrosis; Psoriasis; Time Factors | 1973 |
Letter: Methotrexate dosage schedule.
Topics: Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1974 |
[Drug-induced hepatopathies].
Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Female; Halothane; Humans; Infant, Newborn; Liver; Liver Cirrhosis; Male; Methotrexate; Microsomes, Liver; Pharmaceutical Preparations; Pregnancy; Tetracycline | 1974 |
Jaundice in acute pustular psoriasis.
Topics: Arthropathy, Neurogenic; Bilirubin; Chemical and Drug Induced Liver Injury; Clindamycin; Female; Fusidic Acid; Humans; Jaundice; Leukocytosis; Methotrexate; Middle Aged; Psoriasis; Thrombocytopenia | 1974 |
Effects of methotrexate on the liver in psoriasis.
Topics: Biopsy; Cell Nucleus; Chemical and Drug Induced Liver Injury; Ethanol; Fatty Liver; Follow-Up Studies; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Methotrexate; Necrosis; Psoriasis; Sulfobromophthalein | 1974 |
Methotrexate induced liver disease in psoriasis.
Topics: Administration, Oral; Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Diabetes Complications; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis | 1974 |
Immunosuppressive therapy of ocular inflammatory diseases.
Topics: Adolescent; Adult; Behcet Syndrome; Chemical and Drug Induced Liver Injury; Child; Corneal Transplantation; Cyclophosphamide; Endophthalmitis; Eye Diseases; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Hypersensitivity, Delayed; Immunity; Male; Methotrexate; Middle Aged; Ophthalmia, Sympathetic; Orbit; Pneumonia, Viral; Transplantation Immunology; Uveitis, Anterior | 1969 |
Clinical experience with L-asparaginase.
Topics: Adolescent; Adult; Aged; Asparaginase; Azaserine; Burkitt Lymphoma; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Escherichia coli; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Pancreatitis; Thrombocytopenia | 1970 |
Use of methotrexate in psoriasis.
Topics: Biopsy; Blood Cell Count; Chemical and Drug Induced Liver Injury; Female; Hemoglobinometry; Humans; Kidney Function Tests; Liver; Liver Function Tests; Male; Methotrexate; Pregnancy; Psoriasis | 1972 |
Methotrexate hepatotoxicity in psoriasis--comparison of different dose regimens.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis | 1972 |
Methotrexate-associated liver disease in psoriatic patients.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies | 1972 |
Liver damage and methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis | 1971 |
Pulmonary and hepatic complications of methotrexate therapy of psoriasis.
Topics: Administration, Oral; Biopsy; Chemical and Drug Induced Liver Injury; Dyspnea; Humans; Lung Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Radiography; Time Factors | 1971 |
Methotrexate and hepatic disease.
Topics: Aged; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Methotrexate; Psoriasis | 1971 |
Treatment of acute leukemia with L-asparaginase--preliminary results on 84 cases.
Topics: Acute Disease; Asparaginase; Asparagine; Blood Coagulation Disorders; Cells, Cultured; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Daunorubicin; Humans; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver Function Tests; Methotrexate; Prednisone; Valine; Vincristine | 1970 |
Hazards of prolonged low-dose methotrexate therapy.
Topics: Adult; Anemia, Aplastic; Blood Cell Count; Chemical and Drug Induced Liver Injury; Hepatomegaly; Humans; Leucovorin; Liver; Liver Function Tests; Male; Methotrexate; Psoriasis; Splenomegaly; Time Factors | 1970 |
[Experience with methotrexate in the management of psoriasis].
Topics: Chemical and Drug Induced Liver Injury; Humans; Injections, Intravenous; Methotrexate; Nausea; Psoriasis; Thrombocytopenia; Time Factors | 1969 |
Absorption of methotrexate and hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Intestinal Absorption; Intestines; Methotrexate; Psoriasis | 1969 |
Liver biopsy in psoriasis.
Topics: Adult; Aged; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis; Transaminases | 1970 |
[Methotrexate in the treatment of psoriasis].
Topics: Adult; Aged; Asthenia; Chemical and Drug Induced Liver Injury; Female; Humans; Leukopenia; Male; Methotrexate; Middle Aged; Psoriasis; Thrombocytopenia | 1970 |
Psoriasis, methotrexate, and cirrhosis.
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver Cirrhosis; Methotrexate; Psoriasis | 1970 |
Methotrexate and psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate; Psoriasis; United States; United States Food and Drug Administration | 1970 |
Pityriasis rubra pilaris vs psoriasis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Humans; Methotrexate; Pityriasis Rubra Pilaris; Psoriasis; Scalp Dermatoses | 1970 |
Liver disease associated with methotrexate treatment of psoriatic patients.
Topics: Adult; Alanine Transaminase; Aminopterin; Arthritis; Aspartate Aminotransferases; Blood Cell Count; Cell Division; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; DNA Replication; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Psoriasis; Sulfobromophthalein; Tetrahydrofolate Dehydrogenase | 1970 |
Evaluation of possible chronic hepatotoxicity from methotrexate for psoriasis.
Topics: Adult; Aged; Alcohol Drinking; Biopsy; Chemical and Drug Induced Liver Injury; Fatty Liver; Female; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methotrexate; Middle Aged; Necrosis; Psoriasis; Sulfobromophthalein | 1970 |
Hepatotoxicity of methotrexate in the treatment of psoriasis.
Topics: Adolescent; Adult; Aged; Alcoholism; Biopsy; Chemical and Drug Induced Liver Injury; Diabetes Complications; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Obesity; Prospective Studies; Psoriasis; Retrospective Studies | 1971 |
Azaribine in the treatment of psoriasis.
Topics: Chemical and Drug Induced Liver Injury; DNA; Humans; Methotrexate; Orotic Acid; Psoriasis; Time Factors; Triazines | 1971 |
[Apropos of 2 accidents during general treatments with methotrexate].
Topics: Aged; Chemical and Drug Induced Liver Injury; Dermatitis; Female; Humans; Hypothermia; Liver; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Psoriasis | 1971 |
Liver damage and methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Humans; Methotrexate | 1971 |
[Hepatotoxicity of antimitotic treatments. Effect of hepatic tests].
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Female; Humans; Liver Function Tests; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Middle Aged; Mitomycins; Neoplasms; Rats; Urethane; Vinblastine; Vincristine | 1968 |
Methotrexate and psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Humans; Liver Function Tests; Methotrexate; Psoriasis | 1969 |
Methotrexate induced hepatitis in childhood leukemia.
Topics: Aminopterin; Biopsy; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Liver Function Tests; Male; Methotrexate; Spironolactone | 1965 |
Hepatotoxic effects of methotrexate.
Topics: Chemical and Drug Induced Liver Injury; Eye Diseases; Humans; L-Lactate Dehydrogenase; Leukemia; Liver; Liver Function Tests; Methotrexate; Transaminases | 1966 |