Page last updated: 2024-08-25

methotrexate and Central Nervous System Neoplasm

methotrexate has been researched along with Central Nervous System Neoplasm in 595 studies

Research

Studies (595)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's43 (7.23)18.2507
2000's175 (29.41)29.6817
2010's251 (42.18)24.3611
2020's126 (21.18)2.80

Authors

AuthorsStudies
Batchelor, T; Song, KW1
Advani, R; Alharthy, H; Ayers, A; Ayers, EC; Barlow, CM; Barrett-Campbell, O; Caimi, PF; Chavez, JC; Cohen, J; David, KA; Del Prete, C; Echalier, B; Fu, T; Grover, NS; Hill, BT; Huntington, SF; Kahl, BS; Kallam, A; Kamdar, M; Karmali, R; Khan, N; Landsburg, DJ; Lansigan, F; Law, J; Lazaryan, A; Lee, J; Liu, J; Liu, Y; Major, A; Malecek, MK; McCook, AA; Nakhoda, S; Ollila, TA; Olszewski, A; Orellana-Noia, VM; Portell, CA; Raghunathan, V; Reed, DR; Rojek, AE; Romancik, J; Saeed, H; Sen, JM; Shah, H; Smith, SM; Snow, A; Sohail, MA; Spinner, MA; Spurgeon, SE; Stephens, DM; Switchenko, J; Voorhees, TJ; Watkins, M; Yellala, A1
Balikov, DA; Betz, BL; Cani, AK; Chinnaiyan, AM; Devisetty, LV; Hu, K; Liu, CJ; Rao, RC; Tomlins, SA; Venneti, S1
Chiattone, C; Federico, M; Ferreri, AJM; Fischer, T; Zing, N1
Fujiwara, S; Imoto, N; Ishihara, S; Ito, R; Kurahashi, S; Sakai, T; Sugiura, I; Suzuki, Y; Yamamoto, S1
Grommes, C; Schaff, LR2
Grommes, C; Modelevsky, L; Reiss, SN; Yerram, P1
Azumi, M; Fujihara, T; Mizobuchi, Y; Nakajima, K; Takagi, Y1
Chukwueke, U; Grommes, C; Nayak, L1
Bansal, R; Bhojwani, D; Wayne, AS1
Anzalone, N; Bernardi, M; Calimeri, T; Ferreri, AJ; Mastaglio, S; Steffanoni, S1
Barraclough, A; Gregory, GP; Hamad, N; Keane, C; Ku, M; Lee, YY; Swain, F; Talaulikar, D; Tatarczuch, M; Wight, J1
Deng, X; Luo, X; Wang, X; Zhang, Q; Zhang, Y; Zhu, Y1
Fukuo, Y; Futamura, G; Hiramatsu, R; Hu, N; Kashiwagi, H; Kawabata, S; Miyatake, SI; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M; Watanabe, T; Yoshimura, K1
Agbetiafa, K; Ahearne, M; Barlow, BR; Calimeri, T; Cheah, CY; Choquet, S; Clavert, A; Cwynarski, K; Durot, E; Ebsworth, TJ; El Galaly, TC; Elliot, J; Eyre, TA; Fernandez, R; Ferreri, AJM; Forgeard, N; Fox, CP; Gounder, P; Guidetti, A; Hamad, N; Htut, TW; Khwaja, J; Kirkwood, AA; Ku, M; Lebras, L; Lees, C; Lewis, KL; Liu, Q; Lombion, N; Lopez-Garcia, A; Manos, K; Martinez-Calle, N; McIlroy, G; McKay, P; Miall, F; Moles-Moreau, MP; Narkhede, M; O'Mahony, D; Preston, G; Renaud, L; Ricard, L; Roulin, L; Rusconi, C; Santarsieri, A; Schorb, E; Scott, H; Shah, N; Smith, J; Soussain, C; Strüßmann, T; Tchernonog, E; Vassallo, F; Wilson, MR; Wong Doo, N; Zayac, AS; Øvlisen, AK1
Shu, HS; Wang, DW; Zhang, Q1
McNeer, JL; Schmiegelow, K1
Acosta, EP; Carlow, D; DeAngelis, LM; Gavrilovic, IT; Grommes, C; Lobbous, M; Mellinghoff, IK; Miller, AM; Nabors, LB; Piotrowski, AF; Ryan, KJ; Schaff, LR; Schofield, R; Sener, U; Skakodub, A; Stone, JB1
Akagi, Y; Hosoi, H; Iwamoto, R; Kosako, H; Matsufusa, T; Murata, S; Murata, SI; Mushino, T; Okamura, T; Sonoki, T1
Flórez, A; Patiño, J; Rivera, JS; Toro, J1
Cho, D; Cho, J; Jo, H; Kang, ES; Kim, SJ; Kim, WS; Yoon, SE1
Fortin Ensign, SP; Gathers, D; Mrugala, MM; Wiedmeier, JE1
Hilal, T; Jain, SP1
Abdelrashid, M; DeAtkine, AB; Fiveash, JB; Kim, J; Lobbous, M; Markert, JM; Mehta, A; Nabors, LB; Oster, RA; Tucker, Z1
Chua, N; Puckrin, R; Shafey, M; Stewart, DA1
Fiori, S; Ismail, A; Radice, T; Ramadan, S; Tarella, C1
Avni, B; Gatt, ME; Goldschmidt, N; Grisaro, S; Gural, A; Lavie, D; Lebel, E; Linetski, E; Lossos, A; Makranz, C; Nachmias, B; Rosenberg, S; Saban, R; Shaulov, A; Siegal, T; Vainstein, V; Zimran, E1
Balzarotti, M; Binder, M; Burger, E; Cabras, G; Cavalli, F; Celico, C; Cozens, K; Cwynarski, K; Deckert, M; Fabbri, A; Falautano, M; Ferranti, A; Ferreri, AJM; Finke, J; Fox, CP; Gørløv, JS; Hemmaway, C; Hertenstein, B; Hess, G; Ielmini, N; Ilariucci, F; Illerhaus, G; Johnson, PW; Keller, U; Krampera, M; Krause, SW; La Rosée, P; Linton, KM; Nonis, A; Orsucci, L; Panse, J; Pennese, E; Pisani, F; Politi, LS; Ponzoni, M; Pukrop, T; Pulczynski, E; Roth, A; Rummel, M; Schmoll, HJ; Schorb, E; Smith, J; Stilgenbauer, S; Thurner, L; Tucci, A; Zanni, M; Zucca, E1
Ahle, G; Charlotte, F; Choquet, S; Dehais, C; Desjardins, C; Hoang-Xuan, K; Houillier, C; Larrieu-Ciron, D; Le Garff-Tavernier, M; Mathon, B; Mokhtari, K; Morales-Martinez, A; Nichelli, L1
Cohen, AL; Colman, H; Gelhard, S; Maxwell, A; Mendez, JS1
Chen, X; Li, Z; Lin, Z; Liu, L; Xu, B; Zeng, H1
Kowalski, T; Nilius-Eliliwi, V; Schlegel, U; Schroers, R; Seidel, S1
Fujita, M; Nakao, T; Okuda, T; Takahashi, JC; Yoshioka, H1
Faria, MJ; Fernanda, T; Rita, D; Rui, B1
Bobillo, S; Cheah, CY; Cwynarski, K; El-Galaly, TC; Evens, AM; Eyre, TA; Ferreri, AJM; Lewis, KL; Maurer, MJ; McKay, P; Savage, KJ; Villa, D; Wilson, MR1
Cwynarski, K; Fox, CP; Fricker, H; Ihorst, G; Illerhaus, G; Isbell, LK; Neumaier, S; Okosun, J; Scherer, F; Schorb, E; Steinheber, C; Valk, E; Wendler, J1
Abousaud, A; Orellana-Noia, V1
Cao, A; Chen, H; Chen, L; Du, P; Geng, D; Liu, X; Shen, L; Wu, X1
Chang, Q; Chen, H; Chen, T; Chen, Y; Geng, D; Jiang, T; Lei, J; Li, J; Li, W; Li, XQ; Li, Y; Lin, S; Liu, Y; Lu, D; Lyu, L; Mao, Y; Qiu, X; Song, Y; Wang, B; Wang, Y; Wang, Z; Wu, J; Yu, JT; Zhang, X; Zhuang, D1
Nagane, M1
Baehring, JM; Kaulen, LD1
Liu, B; Shi, X; Wang, Z; Xie, X; Xu, D; Zhang, N1
Araújo Soares, V; Culler, HF; de Oliveira Costa, R; de Pádua Covas Lage, LA; Jacomassi, MD; Meneguin, TD; Pereira, J; Reichert, CO; Reis, DGC; Rocha, V; Zerbini, MCN1
Cheah, CY; Lewis, KL1
Al-Athamen, K; Barrett, O; Gourevitch, A; Gozlan, A; Grinbaum, U; Kaisman-Elbaz, T; Levi, E; Peles, I; Porges, T; Rabinovich, A; Zektser, M1
Abe, K; Arakawa, Y; Asai, A; Asano, K; Fukuda, H; Gomyo, M; Katayama, H; Kinoshita, M; Koga, T; Kojima, M; Mishima, K; Mizusawa, J; Momii, Y; Nagane, M; Nakamura, S; Narita, Y; Natsumeda, M; Nishikawa, R; Sasaki, A; Sasaki, H; Sasaki, N; Sasayama, T; Shibahara, I; Shinojima, N; Sumi, M; Tamaru, JI; Tsuchiya, K; Tsurubuchi, T; Yamasaki, F; Yoshimoto, K1
MacDonald, D; Nair, VJ; Samant, R; Song, J; Volpini, ME1
Curry, LD; Iragavarapu, C; Keller, P; Krem, MM; Li, N; Monohan, GP; Munker, R; Nozad, S; Pryor, P; Yan, D1
Bobillo, S; Cwynarski, K; Ferreri, AJM; Khwaja, J1
Berinstein, N; Crump, M; Drori, AK; Hicks, LK; Kridel, R; Liu, J; Prica, A; Suleman, A1
Aoki, K; Hirano, M; Ito, S; Kano, T; Kitano, Y; Kondo, Y; Kurahashi, S; Lushun, C; Maeda, S; Mizutani, N; Motomura, K; Nagata, Y; Natsume, A; Ohka, F; Ohno, M; Oyama, H; Saito, R; Seki, Y; Shimizu, H; Suzaki, N; Takasu, S; Takeuchi, K; Tanahashi, K; Wakabayashi, K; Wakabayashi, T; Yamaguchi, J; Yamazaki, S1
Bobillo, S; Cwynarski, K; Wilson, MR2
Dabaja, BS; Fang, PQ; Nasr, L; Short, NJ; Wu, SY1
Huang, Y; Jiang, H; Liang, Y; Qian, W; Xu, X; Yu, T; Yuan, X1
Cheng, CL; Fang, WQ; Hou, HA; Lin, CP; Ma, WL; Tien, HF; Tsai, CH; Yeh, PT1
Cho, SG; Choi, BO; Jeon, YW; Kim, TY; Min, GJ; O, JH; Park, G; Park, YH1
Borawska, A; Dabrowska-Iwanicka, A; Domanska-Czyz, K; Druzd-Sitek, A; Konecki, R; Kotarska, M; Lapinska, G; Michalski, W; Mroz-Zycinska, E; Osiadacz, W; Osowiecki, M; Ostrowska, B; Paszkiewicz-Kozik, E; Poplawska, L; Romejko-Jarosinska, J; Rymkiewicz, G; Swierkowska, M; Szymanski, M; Tajer, J; Targonski, L; Walewski, J; Wojciechowska-Lampka, E; Wojewodzka-Mirocha, M1
Agrawal, P; Bachanova, V; Berg, S; Bond, DA; Cai, J; Carter, J; Chang, J; Cleveland, J; David, KA; Epperla, N; Evens, AM; Folstad, M; Glantz, M; Goldlust, SA; Graber, J; Habib, A; Hossain, N; Kahl, B; Karmali, R; Kim, MS; Kim, SH; Kumar, P; Lin, Y; Major, A; Malecek, MK; Martin, P; Mier-Hicks, A; Naik, S; Ney, D; Ollila, TA; Rajakumar, P; Reddy, N; Rubenstein, J; Salman, S; Sieg, A; Singer, S; Smith, SM; Spurgeon, S; Strouse, C; Sundaram, S; Torka, P; Tsang, M; Vaca, R; Vendiola, JA; Venugopal, P; Zayac, A1
Andayani, YD; Andriani, M; Diansari, Y; Djamaludin, N; Syahrir, M; Wirdah, A1
Chan, A; Ciurea, SO; Doh, J; Griffin, SP; Jeyakumar, D; Kongtim, P; Lee, BJ; O'Brien, S1
Akita, T; Asano, K; Fudaba, H; Fujii, K; Hosoya, T; Ideguchi, M; Kakuta, K; Kambe, A; Katayama, K; Kawasaki, Y; Koizumi, S; Kurozumi, K; Nagashima, H; Nakayama, N; Natsumeda, M; Nishibuchi, I; Nishizaki, T; Sasayama, T; Shimabukuro, T; Sugiyama, K; Taguchi, K; Tanaka, K; Tsukamoto, Y; Yamasaki, F; Yasutomo, M; Yonezawa, U; Yoshida, K1
Bennett, R; Berkahn, L; Christophers, M; Coomarasamy, C; Issa, S; Jackson, S; Ruskova, A; Theakston, E; Wong, S1
Liu, R; Qin, Y; Ren, C; Wu, D; Zhang, W; Zhang, X1
Chen, H; Duan, X; Lin, D; Liu, H; Miao, C; Nie, T; Wu, J; Zhang, X; Zheng, Y; Zhong, W1
Cwynarski, K; Khwaja, J1
Ahrweiller, F; Alfonsi, M; Ammarguellat, H; Antoni, D; Belkacemi, Y; Benchalal, M; Bernier-Chastagner, V; Colin, P; Coutte, A; Créhange, G; Dadoun, N; Feuvret, L; Hamidou, H; Hoang-Xuan, K; Houillier, C; Jacob, J; Jouglar, E; Lang, P; Pointreau, Y; Soussain, C; Thomas-Joulié, A; Vieillot, S1
DeAngelis, LM; Grommes, C; Nandakumar, S; Omuro, AMP; Schaff, LR; Therkelsen, KE1
Baba, S; Hiu, T; Imaizumi, Y; Izumo, T; Kato, T; Matsuo, A; Matsuo, T; Miyazaki, Y; Morimoto, S; Morofuji, Y; Niino, D; Okano, S; Ujifuku, K; Yamaguchi, S; Yoshida, K; Yoshida, M1
Miyazaki, K1
Mishra, P; Moharana, B; Palanisamy, S; Parija, S1
Akhtari, M; Brothers, J; Cao, H; Hino, C; Lacy, C; Mirshahidi, H; Park, K1
Bao, H; Cao, B; Cen, X; Gao, Y; Liang, R; Liu, A; Qin, Y; Shi, Y; Wang, J; Wang, N; Xie, Y; Xue, M; Yang, Y; Zhang, H; Zhang, L; Zhang, M; Zhang, Q; Zhang, W; Zhao, Y; Zhong, K1
Bishton, MJ; Cheah, CY; Cwynarski, K; El-Galaly, TC; Eyre, TA; Fox, CP; Hawkes, EA; Jakobsen, LH; Lewis, KL; Maurer, MJ; Savage, KJ; Smedby, KE; Villa, D1
Amatya, VJ; Horie, N; Khairunnisa, NI; Onishi, S; Ozono, I; Taguchi, A; Takayasu, T; Takeshima, Y; Yamasaki, F; Yonezawa, U1
Gao, J; Peng, X; Wang, L1
Hayano, A; Hondoh, H; Ikenaka, K; Kano, Y; Takashima, Y; Yamanaka, R; Yoshimura, T1
Ambinder, R; Dzaye, O; Estephan, F; Gladstone, DE; Grossman, SA; Holdhoff, M; Kamson, DO; Lambrecht, S; Lin, DDM; Swinnen, L; Wagner-Johnston, N; Ye, X1
Bazan, F; Chaigneau, L; Curtit, E; Dobi, E; Mansi, L; Menneveau, N; Meynard, G; Paillard, MJ; Pivot, X; Royer, B; Villanueva, C1
Chen, C; Ma, X; Wei, X; Zhuo, H1
Bai, T; Dai, X; Guo, Z; Li, Y; Lu, Q; Tian, X; Yao, J; Zhang, Y; Zhong, Y1
Chong, G; Churilov, L; Garwood, MJ; Hawkes, EA1
Chen, H; Liu, Z; Xu, J; Yang, J; Yang, Y1
Pan, E; Singh, PK1
Abraham, J; Agapé, P; Ahle, G; Aidaoui, B; Alentorn, A; Amiel, A; Bay, JO; Blonski, M; Boyle, E; Campello, C; Casasnovas, O; Cassoux, N; Charlotte, F; Chauchet, A; Chebrek, S; Chinot, O; Choquet, S; Colin, P; Costopoulos, M; Damaj, G; Delgadillo, D; Delwail, V; Douzane, H; Fabbro, M; Feuvret, L; Fornecker, LM; Genet, D; Ghesquières, H; Gressin, R; Gyan, E; Haioun, C; Hoang-Xuan, K; Houillier, C; Houot, R; Jardin, F; Kas, A; Lamy, T; Laribi, K; Le Garff-Tavernier, M; Marolleau, JP; Martin-Duverneuil, N; Mathon, B; Mokhtari, K; Moles-Moreau, MP; Moluçon-Chabrot, C; Morschhauser, F; Oberic, L; Peyre, M; Schmitt, A; Serrier, C; Soubeyran, P; Soussain, C; Tabouret, E; Taillandier, L; Tamburini, J; Tempescul, A; Touitou, V; Waultier, A1
Beca, JM; Keech, J; Kouroukis, CT; Mow, E; Raza, K1
Calimeri, T; Cummin, T; Cwynarski, K; De Marco, B; Eyre, TA; Fabbri, A; Ferreri, AJM; Fox, CP; Illerhaus, G; Kasenda, B; Krampera, M; Linton, K; Martinez-Calle, N; Ninkovic, S; Orsucci, L; Schorb, E; Smith, J; Trefz, S; Yallop, D1
Aldrees, S; Jeeva-Patel, T; Margolin, E1
Debacker, KC; Derstine, B; Pai, MP; Su, GL; Sullivan, J; Wang, SC1
Beham-Schmid, C; Deutsch, A; Greinix, H; Hatzl, S; Neumeister, P; Pichler, M; Posch, F; Prochazka, KT; Stöger, H1
Hayano, A; Takashima, Y; Yamanaka, R2
Abboud, MR; Chahrour, M; El-Khoury, H; El-Solh, H; Ghanem, KM; Hamideh, D; Muwakkit, SA; Saab, R; Saifi, O; Tamim, H; Tarek, N1
Alchawaf, A; Buckley, H; Culligan, DJ; Cwynarski, K; Eyre, TA; Fourali, S; Fox, CP; Horan, M; Kassam, S; Kelsey, P; Lim, YJ; Linton, K; Martinez-Calle, N; McCulloch, R; McKay, P; Ngu, L; Osborne, W; Poynton, E; Rafferty, M; Rowntree, C; Scott, G; Smith, J; Wright, J; Yallop, D1
Kaneko, K; Kawazoe, M; Nanki, T1
Liu, F; Xun, Y; Yang, A; Yang, H; You, H1
Fukai, J; Hamano, M; Hondoh, H; Iwadate, Y; Kajiwara, K; Kobayashi, T; Takashima, Y; Yamanaka, R1
Zhang, Y; Zhou, DB1
Kobayashi, K; Lee, J; Nagane, M; Saito, K; Sasaki, N; Shibahara, J; Shimizu, S; Shiokawa, Y; Suzuki, K; Takayama, N; Yamagishi, Y1
Alañá, M; Barbero-Bordallo, N; Barceló, MI; Barón, M; Bobillo, S; Bruna, J; Caballero, AC; Cacabelos, P; Caldú Agud, R; Camro, I; Dlouhy, I; Encuentra, M; Erro, ME; Estela, J; Gállego Pérez-Larraya, J; García Molina, E; García-Catalán, G; Gómez-Vicente, L; Graus, F; Huertas, N; Ibáñez-Juliá, MJ; Lado, T; Martínez, P; Mercadal, S; Muntañola, A; Salar, A; Sancho, JM; Solé-Rodríguez, M; Velasco, R; Vidal, N1
Haapasaari, KM; Jantunen, E; Kaprio, E; Karihtala, P; Kauppila, S; Kuittinen, O; Kuitunen, H; Kuusisto, M; Makkonen, V; Turpeenniemi-Hujanen, T1
Byeon, S; Cho, J; Hur, JY; Jeong, H; Kim, EJ; Kim, H; Kim, SJ; Kim, WS; Ko, YH; Koh, Y; Miyazaki, K; Oguchi, M; Sohn, I; Suzuki, R; Taguchi, S; Yamaguchi, M; Yoon, DH; Yoon, SE; Yoon, SS1
George, J; Goncalves, PH; Jaffe, ES; Little, RF; Lurain, K; Martin, S; Pittaluga, S; Polizzotto, MN; Ramaswami, R; Steinberg, SM; Tamula, MA; Uldrick, TS; Wang, HW; Widell, A; Wolters, PL; Yarchoan, R; Yuan, CM1
Juul-Jensen, K; Larsen, TS; Møller, MB; Pedersen, CB; Poulsen, FR; Schulz, MK; Sommer-Sørensen, R1
Ahearne, M; Cheung, CK; Creasey, T; Cwynarski, K; Elliot, J; Eyre, TA; Fox, CP; Khwaja, J; Linton, K; Martinez-Calle, N; McKay, P; Miall, F; Mula Kh, A; Parsons, KE; Preston, G; Schofield, J; Shah, N; Smith, J; Timmins, MA; Wilson, MR1
Bazargan, A; Filshie, R; Gilberston, M; Gregory, GP; Ku, M; Opat, S; Paul, E; Quach, H; Shortt, J; Tam, C; Tatarczuch, M; Tey, A1
Bode, U; Deckert, M; Egerer, G; Engert, A; Fimmers, R; Fliessbach, K; Herrlinger, U; Klockgether, T; Kowoll, A; Kroschinsky, F; Pels, H; Reichmann, H; Schackert, G; Schlegel, U; Schlömer, S; Schmidt-Wolf, IGH; Seidel, S; Vogt-Schaden, M1
Chen, F; Guo, H; Huang, L; Jiang, X; Li, W; Liang, Z; Liu, S; Ou, Q; Pang, D; Wei, X; Wu, X; Zhou, D1
Chang, X; Guo, Y; Hu, R; Hui, W; Su, L; Sun, W; Zhang, Y; Zhao, H1
Avivi, I; Blumenthal, DT; Bokstein, F; Gibstein, L; Perry, C; Ram, R; Sarid, N; Weiss-Meilik, A1
Grommes, C; Holdhoff, M; Kaley, TJ; Mrugala, MM; Nayak, L; Perez-Heydrich, C; Swinnen, LJ1
Ballester, LY; Choi, HA; Dono, A; Esquenazi, Y; Hasbun, R; Husein, N; Ybarra, C1
Bairey, O; Shargian-Alon, L; Siegal, T1
Grommes, C1
Alonso, JR; Alvarez-Pinzon, AM; Borro, M; Herrera, D; Valerio, JE; Wolf, A1
Enya, M; Hirota, T; Horikawa, Y; Iizuka, K; Iwama, T; Kato, T; Kito, Y; Kuwabara-Ohmura, Y; Liu, Y; Miyazaki, T; Mizuno, M; Nonomura, K; Ohe, N; Saigo, C; Suwa, T; Takao, K; Tani, A; Yabe, D1
Asou, D; Fudaba, H; Fujiki, M; Hirakawa, T; Kawasaki, Y; Matsushita, W; Momii, Y; Onishi, K; Sugita, K1
Du, H; Xiao, H; Ye, X; Yu, J; Zhang, L1
Bakunina, K; Bromberg, JEC; Dirven, L; Doorduijn, JK; Issa, S; van den Bent, MJ; van der Meulen, M1
El Darsa, H; Ghosh, S; Owen, C; Peters, A; Puckrin, R; Stewart, D1
Chae, EJ; Chae, H; Cho, H; Huh, J; Jeong, H; Kim, H; Kim, KW; Kim, S; Lee, JB; Lee, K; Lee, SW; Park, CS; Ryu, JS; Suh, C; Yoon, DH1
Balke-Want, H; Borchmann, P; Bröckelmann, PJ; Deckert, M; Gillessen, S; Gödel, P; Heger, JM; Kreissl, S; Naendrup, JH; Sieg, N; Simon, F; von Tresckow, B1
Ikeda, R; Ohno, R; Saito, K; Takeshima, H; Tazaki, T; Urata, S; Yoshikawa, N1
Puckrin, R; Stewart, DA1
Cwynarski, K; Eyre, TA; Fox, CP; Martinez-Calle, N; McKay, P; Wilson, MR1
Duell, J; Einsele, H; Gerhard-Hartmann, E; Heidemeier, A; Krummenast, FC; Rosenwald, A; Steinhardt, MJ; Topp, MS1
Batlevi, CL; Bobillo, S; Caron, PC; Dogan, A; Ghione, P; Hamilton, A; Hamlin, PA; Horwitz, SM; Joffe, E; Kumar, A; Matasar, MJ; Mondello, P; Moskowitz, A; Noy, A; Owens, CN; Palomba, ML; Sermer, D; Seshan, VE; Straus, D; von Keudell, G; Younes, A; Zelenetz, AD1
Dharnidharka, VR; Hayashi, RJ; Semkiu, KM1
Kiyoi, H; Shimada, K1
Kim, N; Kim, SJ; Kim, WS; Lim, DH; Yoon, SE1
Adlington, J; Auer, D; Bessell, EM; Bishton, MJ; Byrne, P; Figueroa, R; Fox, CP; Grainge, MJ; James, E; Kaji, FA; Martinez-Calle, N; O'Donoghue, M; Paine, S; Smith, S; Sovani, V1
Chen, Y; Chng, WJ; de Mel, S; Goh, YT; Grigoropoulos, NF; Lee, YS; Lim, ST; Liu, X; Nagarajan, C; Ng, LCK; Ong, SY; Phipps, C; Tan, MSY; Tan, YC; Yong, KY1
Armand, P; Batchelor, TT; Chen, YB; DeFilipp, Z; El-Jawahri, A; Li, S; Nayak, L; Wang, N1
Bai, X; Chen, Y; Ji, N; Liu, F; Liu, J; Liu, Y; Qian, J; Qiu, X; Sun, S; Sun, X; Wang, Y; Zhu, H1
Chang, JH; Cheong, JW; Cho, H; Jang, JE; Kim, JS; Kim, SH; Kim, SJ; Kim, Y; Kim, YR; Lee, JY; Min, YH; Suh, CO; Yang, WI1
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Baldini, L; Balzarotti, M; Bernardi, M; Bobbio, F; Brandes, AA; Caligaris Cappio, F; Corazzelli, G; Dell'Oro, S; Ferreri, AJ; Foppoli, M; Ilariucci, F; Montanari, M; Picozzi, P; Ponzoni, M; Reni, M; Spina, M; Stelitano, C; Tosoni, A; Zaja, F1
Fischer, L; Herrlinger, U; Jahnke, K; Korfel, A; Martus, P; Thiel, E; Weller, M1
Bello, JL; Bethencourt, C; Deben, G; Feliu, E; Hernandez-Rivas, JM; Oriol, A; Parody, R; Ribera, JM; Rivas, C; Sancho, JM1
Chalmers, LM; Chamberlain, M; Chowdhary, S; Green, MR; Lombardi, KM1
Partap, S; Spence, AM1
Derigs, G; Feuerhake, F; Finke, J; Frickhofen, N; Guttenberger, R; Ihorst, G; Illerhaus, G; Marks, R; Ostertag, C; Volk, B1
Motl, S; Stewart, CF; Waters, CM; Zhuang, Y1
Bay, JO; Berthou, C; Bertrand, P; Brion, A; Camilleri-Broët, S; Colombat, P; Delepine, R; Delwail, V; Desablens, B; Lamy, T; Lemevel, A; Linassier, C; Rachieru, P1
Batchelor, T; Gerber, DE; Grossman, SA; Ye, X1
Abrey, LE; DeAngelis, LM; Gavrilovic, IT; Hormigo, A; Yahalom, J1
Cagayan, MS; Lu-Lasala, LR1
Boiardi, A; Botturi, A; Broggi, G; Eoli, M; Erbetta, A; Fariselli, L; Fiumani, A; Gaviani, P; Giovagnoli, AR; Lamperti, E; Marras, CE; Milanesi, I; Pollo, B; Salmaggi, A; Silvani, A1
Deangelis, LM; Iwamoto, FM1
Agarwal, R; Arkenau, HT; Chong, G; Cunningham, D; Horwich, A; Norman, A; Sirohi, B; Trumper, M; Watkins, D; Wotherspoon, A1
Evans, WE; Pui, CH; Relling, MV1
Balis, FM; Bleyer, WA; Brouwers, P; Feusner, J; Hunsberger, S; Miser, J; Nathan, PC; Odom, LF; Poplack, D; Reaman, G; Sather, H; Steinberg, SM; Whitcomb, T; Wolters, PL1
Al-Ali, HK; Dölken, G; Haas, A; Helke, K; Herbst, R; Hirt, C; Kiefer, T; Krüger, WH; Lotze, C; Montemurro, M; Niederwieser, D; Schüler, F; Schwenke, M; Theilig, A; Wolf, HH1
Forero, A; Lobuglio, A; Meredith, R; Nabors, B; Shah, JJ; Shen, S; Yester, M1
Iijima, K; Iki, S; Kida, M; Nakasone, H; Taoka, K; Urabe, A; Usuki, K; Yoshimi, A1
Anagnostopoulos, I; Kiewe, P; Korfel, A; Loddenkemper, C; Reinwald, M; Thiel, E1
Altintas, A; Ayyildiz, O; Cil, T; Kaplan, MA; Kilinc, I1
Bell, BA; Camitta, B; Carroll, AJ; Chauvenet, AR; Devidas, M; Kurtzberg, J; Linda, SB; Martin, PL; Pettenati, MJ; Pullen, J; Shuster, JJ1
DiMaggio, C; Fahey, JB1
Hasegawa, A; Homma, J; Onda, K; Sano, M; Shinbo, Y; Tanaka, R; Tsuchiya, N; Yajima, N; Yamanaka, R1
Digumarti, R; Rajappa, SJ; Uppin, SG1
Batchelor, T; Gerstner, E1
Kaban, LB; Nissenbaum, M; Troulis, MJ1
Homma, J; Hondoh, H; Morii, K; Onda, K; Sano, M; Shinbo, Y; Takahashi, H; Tamura, T; Tanaka, R; Tsuchiya, N; Yajima, N; Yamanaka, R1
Abrey, LE; Mohile, NA1
Carmichael, MG1
Höglund, P; Jönsson, P; Schrøder, H; Seidel, H; Skärby, T; Wiebe, T1
Li, CK; Li, VC1
Barrie, M; Carnin, C; Chinot, O; Hoang-Xuan, K; Omuro, AM; Taillandier, L1
Karantanis, D; Lowe, VJ; Mullan, BP; Nathan, MA; O'eill, BP; Peller, PJ; Subramaniam, RM; Wiseman, GA; Witte, RJ1
Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S1
Abrey, LE; Correa, DD; DeAngelis, LM; Grant, B; Lai, RK; LaRocca, R; Raizer, JJ; Schiff, D; Shah, GD; Yahalom, J1
Adams, H; Alyman, C; Catania, L; Jandet-Brunet, C; Neuberg, DS; Robaey, P; Romero, I; Sallan, SE; Silverman, LB; Stevenson, K; Turek, J; Waber, DP1
Ferreri, AJ; Foppoli, M; Mazza, E; Reni, M1
Bell, S; Doolittle, ND; Fortin, D; Jahnke, K; Knight, KR; Kraemer, DF; Muldoon, LL; Neuwelt, EA1
Barnett, GH; Bhatia, J; Deogaonkar, A; Ebrahim, Z; Elkassabany, NM; Farag, E; Ference, S; Lotto, M; Maurtua, M; Schubert, A1
Feuerhake, F; Finke, J; Illerhaus, G; Müller, F; Ostertag, C; Schäfer, AO1
Baker, A; Hadzic, N; Height, S; Messahel, B; Mycroft, J; Pinkerton, CR; Pritchard-Jones, K; Taj, MM1
Chowers, I; Frenkel, S; Pe'er, J; Shalom, E; Siegal, T; Vicuna-Kojchen, J1
Fischer, L; Kiewe, P; Korfel, A; Martus, P; Thiel, E1
Homma, J; Hondoh, H; Kakuma, T; Morii, K; Sano, M; Shinbo, Y; Takahashi, H; Tamura, T; Tanaka, R; Tsuchiya, N; Yajima, N; Yamanaka, R1
Chamberlain, MC; Green, MR1
Cortes, J; Freireich, EJ; Kantarjian, HM; Keating, MJ; O'Brien, SM; Pierce, S1
Callans, LS; Jardines, L; Torosian, MH1
Camitta, BM; Civin, CJ; Ganick, DJ; Kamen, BA; Lauer, SJ; Leventhal, BG; Mahoney, DH; Shuster, JJ; Steuber, CP1
Hołowiecki, J; Kachel, L; Krawczyk, M; Krzemień, S; Rudzka, E; Wojnar, J1
Bailey, C; Chessells, JM; Richards, SM1
Crist, WM; Hancock, ML; Hudson, M; Kun, L; Mahmoud, H; Mulhern, RK; Pui, CH; Ribeiro, RC; Rivera, GK; Sandlund, JT1
Bouffet, E; Doz, F; Gentet, JC; Mottolese, C; Plantaz, D; Ponvert, D; Roche, H; Stephan, JL; Thyss, A; Tron, P1
Arrighini, A; Carli, M; Cordero di Montezemolo, L; Fears, TR; Fossati Bellani, F; Garrè, ML; Guazzelli, C; Jankovic, M; Rosso, P; Terracini, B1
Butler, RW; Finlay, JL; Hill, JM; Meyers, PA; Steinherz, PG1
Cher, L; Glass, J; Gruber, ML; Hochberg, FH1
Argüello, A; Barrantes, JC; Barrantes, M; García, I; Jiménez, R; Lobo-Sanahuja, F1
Coccia, PF; Gilchrist, GS; Hammond, GD; O'Brien, RT; Sather, HN; Tubergen, DG; Waskerwitz, MJ1
Boiardi, A; Salmaggi, A; Silvani, A1
DeAngelis, LM; Delattre, JY; Freilich, RJ; Monjour, A1
Cher, L; Glass, J; Harsh, GR; Hochberg, FH1
Bertino, JR; DeAngelis, LM; Fleisher, M; Lin, S; Tong, WP1
DaSilva, V; Dent, S; Eapen, L; Girard, A; Hugenholtz, H; Stewart, DJ1
Barton, MB; Liew, KH; O'Brien, PC; Olver, IN; Poulsen, MG; Roos, DE; Trotter, GE; Walker, QJ1
Kamio, M; Mochizuki, T; Sawada, N; Tanaka, S1
Fishburne, BC; Neuwelt, EA; Rosenbaum, JT; Wilson, DJ1
Chamberlain, MC; Kormanik, PA1
Farese, VL; Girard, PM; Jacomet, C; Lebrette, MG; Monfort, L; Rozenbaum, W1
Ferracini, R1
Abrey, LE; DeAngelis, LM; Yahalom, J2
Cherlow, JM; Gaynon, PS; Lukens, JN; Nachman, J; Sather, HN; Sensel, MG; Trigg, ME; Wolff, L1
Cheng, AL; Hung, RL; Liu, MY; Uen, WC; Wang, CH; Yeh, KH1
Korfel, A; Thiel, E1
Brouwers, P; deSmet, M; Heiss, J; Jaffe, E; Kohler, D; Nussenblat, R; Patronas, N; Pearson, D; Sandor, V; Simon, R; Stark-Vancs, V; Whitcup, SM; Wittes, R1
Boiardi, A; Broggi, G; Fariselli, L; Pozzi, A; Salmaggi, A; Silvani, A1
Anami, K; Asami, K; Fujimoto, T; Furuyama, T; Gushiken, T; Hatae, Y; Hirota, T; Ijichi, O; Iwai, A; Kanegane, H; Katano, N; Kawano, Y; Kikuta, A; Koizumi, S; Mimaya, J; Miyake, M; Mugishima, H; Nishi, K; Nishikawa, K; Sekine, I; Takeda, T; Tsurusawa, M; Watanabe, A; Yamamoto, Y; Yatabe, M1
Damek, D; Guha-Thakurta, N; Hochberg, FH; Pollack, C1
Bang, YJ; Ha, SW; Huh, DS; Kim, IH; Park, CI; Wu, HG1
Filatov, LB; Konstantinova, TS; Shalaev, VA1
Abramov, A; Attias, D; Ballin, A; Burstein, Y; Cividalli, G; Rechavi, G; Sharon, R; Stark, B; Sthoeger, D; Zaizov, R1
Barton, M; Liew, K; O'Brien, P; Olver, I; Poulsen, M; Pratt, G; Roos, D; Trotter, G1
Hattori, T; Matsuda, M; Seki, S; Tabata, K1
Bode, U; Deckert-Schlüter, M; Fischer, HP; Glasmacher, A; Kleinschmidt, R; Oehring, R; Pels, H; Schlegel, U1
Cairo, MS; Finlay, JL; Gururangan, S; Meadows, AT; Sposto, R1
Hori, S; Kawashima, H; Mori, T; Morikawa, N; Takeyama, M1
Abe, T; Hori, S; Kawashima, H; Mori, T; Morikawa, N; Takeyama, M1
Attal, M; Besson, C; Brière, J; Haioun, C; Lederlin, P; Lepage, E; Reyes, F; Rose, C; Simon, D; Sonet, A; Thieblemont, C; Tilly, H1
Al Bahrani, B; Delaney, G; Henderson, C1
Ferreri, AJ; Reni, M; Villa, E1
Holen, A; Moe, PJ1
Arnold, R; Bartram, CR; Böhme, A; Freund, M; Ganser, A; Gökbuget, N; Hoelzer, D; Kneba, M; Langer, W; Lipp, T; Ludwig, WD; Maschmeyer, G; Messerer, D; Rieder, H; Thiel, E; Weiss, A1
Garcia-Manero, G; Kantarjian, HM1
Bamberg, M; Brugger, W; Dichgans, J; Herrlinger, U; Kanz, L; Kortmann, RD; Schabet, M; Weller, M1
Achour, E; Azar, N; Belanger, C; Cassoux, N; Delattre, JY; Gerber, S; Hoang-Xuan, K; Leblond, V; Levy, V; Ribrag, V; Soussain, C; Suzan, F1
Bernardi, M; Camba, L; Ciceri, F; Dell'Oro, S; Ferreri, AJ; Ponzoni, M; Reni, M; Spina, M; Terreni, MR; Tomirotti, M; Villa, E1
Ashley, D; Cher, L; Ng, S; Rosenthal, MA1
Bessell, EM; Byrne, P; Graus, F; Holland, I; López-Guillermo, A; Petit, J; Verger, E; Villá, S1
Bode, U; Deckert, M; Fimmers, R; Fliessbach, K; Glasmacher, A; Helmstaedter, C; Kleinschmidt, R; Klockgether, T; Pels, H; Schlegel, U; Schmidt-Wolf, I; Van Roost, D1
DeAngelis, LM; Gijtenbeek, JM; Rosenblum, MK1
Batchelor, T; Kaufman, D; Leahy, N1
Ferreri, AJ; Reni, M1
Finke, J; Korfel, A; Schmidt-Wolf, I; Thiel, E1
Bessell, EM; Byrne, P; Graus, F; López-Guillermo, A; Montserrat, E; Nomdedeu, B; Petit, J; Verger, E; Villá, S1
Bamberg, M; Benöhr, C; Brugger, W; Deckert, M; Dichgans, J; Engel, C; Herrlinger, U; Kanz, L; Kortmann, RD; Krauseneck, P; Küker, W; Meisner, C; Mergenthaler, HG; Schabet, M; Schmeck-Lindenau, HJ; Weller, M; Wiestler, OD1
Bokstein, F; Lossos, A; Lossos, IS; Siegal, T1
Casanova, M; Cefalo, GS; Collini, P; Ferrari, A; Fossati-Bellani, F; Gasparini, M; Luksch, R; Massimino, M; Polastri, D; Spreafico, F; Terenziani, M1
Basso, U; Brandes, AA1
Andrykowski, MA; Brady, MJ; Gregg, ME; Henslee-Downey, PJ; Lamb, DG; Schmitt, FA1
Hann, IM1
Akiyama, Y; Asato, R; Ito, M; Konishi, J; Kubota, M; Mikawa, H; Miki, Y; Okumura, R1
Horoupian, DS; Page, KA; Vogel, H1
Borowitz, MJ; Crist, WM; Falletta, JM; Foreman, E; Patterson, R; Pullen, DJ; Shuster, JJ; Vietti, TJ; Wharam, M1
García Zueco, JC; López Gómez, L; Martín Guerrero, Y; Torres Gómez, M1
Mead, GM; Sweetenham, JW; Whitehouse, JM1
Cervos-Navarro, J; Dienemann, D; Jautzke, G; Langford, A; Pohle, HD; Ruf, B; Schürmann, D; Stein, H1
Ablin, AR; Halberg, F; Kramer, JH; Moore, IM; Wara, W1

Reviews

103 review(s) available for methotrexate and Central Nervous System Neoplasm

ArticleYear
Treatment of Primary CNS Lymphoma: Maximizing Clinical Benefit, Minimizing Neurotoxicity.
    Current oncology reports, 2021, 09-15, Volume: 23, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neurotoxicity Syndromes; Prognosis

2021
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
    Critical reviews in oncology/hematology, 2021, Volume: 167

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, T-Cell, Peripheral; Methotrexate; Prognosis

2021
Primary central nervous system lymphoma.
    Blood, 2022, 09-01, Volume: 140, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Tumor Microenvironment

2022
Primary Central Nervous System Lymphomas.
    Hematology/oncology clinics of North America, 2022, Volume: 36, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Stem Cell Transplantation

2022
Managing therapy-associated neurotoxicity in children with ALL.
    Hematology. American Society of Hematology. Education Program, 2021, 12-10, Volume: 2021, Issue:1

    Topics: Adolescent; Antibodies, Bispecific; Anticonvulsants; Antineoplastic Agents; Central Nervous System Neoplasms; Disease Management; Female; Glucocorticoids; Humans; Immunotherapy, Adoptive; Leukemia; Male; Methotrexate; Neurotoxicity Syndromes

2021
A narrative review of consolidation strategies for young and fit patients with newly-diagnosed primary central nervous system lymphoma.
    Expert review of hematology, 2022, Volume: 15, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Transplantation, Autologous

2022
Diagnosis and management of primary central nervous system lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance.
    Internal medicine journal, 2022, Volume: 52, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Consensus; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Randomized Controlled Trials as Topic

2022
Management of CNS Disease in Pediatric Acute Lymphoblastic Leukemia.
    Current hematologic malignancy reports, 2022, Volume: 17, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies

2022
Central Nervous System Lymphoma: Novel Therapies.
    Current treatment options in oncology, 2022, Volume: 23, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local

2022
Advances in therapeutic strategies for primary CNS B-cell lymphomas.
    Expert review of hematology, 2022, Volume: 15, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Lymphoma, B-Cell; Methotrexate; Transplantation, Autologous

2022
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis.
    Critical reviews in oncology/hematology, 2022, Volume: 176

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cyclophosphamide; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Network Meta-Analysis; Prospective Studies; Rituximab; Vincristine

2022
Optimum Methotrexate Exposure in Patients With Suspected or Confirmed CNS Invasive Hematological Malignancies: A Systematic Critical Review.
    Therapeutic drug monitoring, 2023, 06-01, Volume: 45, Issue:3

    Topics: Adult; Central Nervous System Neoplasms; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2023
CNS prophylaxis for diffuse large B-cell lymphoma.
    The Lancet. Oncology, 2022, Volume: 23, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local

2022
Secondary Central Nervous System Lymphoma: Updates in Treatment and Prophylaxis Strategies.
    Current treatment options in oncology, 2022, Volume: 23, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasms, Second Primary; Rituximab

2022
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
    Journal of hematology & oncology, 2022, 09-29, Volume: 15, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Consensus; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Positron Emission Tomography Computed Tomography; Retinal Neoplasms; Rituximab; Transplantation, Autologous; Vitreous Body

2022
Treatment Options for Recurrent Primary CNS Lymphoma.
    Current treatment options in oncology, 2022, Volume: 23, Issue:11

    Topics: Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Busulfan; Central Nervous System Neoplasms; Cranial Irradiation; Cyclophosphamide; Cytarabine; Humans; Immune Checkpoint Inhibitors; Lenalidomide; Lymphoma, Non-Hodgkin; Methotrexate; Nivolumab; Pemetrexed; Procarbazine; Prospective Studies; Receptors, Chimeric Antigen; Retrospective Studies; Rituximab; Temozolomide; Thiotepa; Vincristine

2022
Prophylaxis strategies containing high dose intravenous methotrexate on preventing CNS relapse for patients with diffuse large B-cell lymphoma at intermediate to high risk: A study based on 12 cohorts in the rituximab era.
    International immunopharmacology, 2022, Volume: 113, Issue:Pt A

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Rituximab; Vincristine

2022
Performance status, comorbidities, and cycles of methotrexate exert the greatest influence on outcomes of primary and secondary CNS lymphomas: the Lexington experience.
    Annals of hematology, 2023, Volume: 102, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Comorbidity; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies

2023
Prevention and management of secondary central nervous system lymphoma.
    Haematologica, 2023, 03-01, Volume: 108, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Retrospective Studies

2023
CNS prophylaxis in aggressive B-cell lymphoma.
    Hematology. American Society of Hematology. Education Program, 2022, 12-09, Volume: 2022, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Rituximab

2022
Central Nervous System Prophylaxis and Treatment in Acute Leukemias.
    Current treatment options in oncology, 2022, Volume: 23, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Controversies in central nervous system prophylaxis of high-risk diffuse large B-cell lymphoma.
    Current opinion in oncology, 2023, 09-01, Volume: 35, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies; Rituximab; Vincristine

2023
Efficacy and safety of first-line combination therapy versus monotherapy for vitreoretinal lymphoma: a systematic review and meta-analysis.
    BMC ophthalmology, 2023, Nov-22, Volume: 23, Issue:1

    Topics: Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Prospective Studies; Retinal Neoplasms; Vitreous Body

2023
Review of rituximab in primary CNS lymphoma.
    Journal of the neurological sciences, 2020, Mar-15, Volume: 410

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Rituximab

2020
Advances and challenges in the treatment of primary central nervous system lymphoma.
    Journal of cellular physiology, 2020, Volume: 235, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stem Cell Transplantation

2020
[Primary central nervous system lymphomas].
    Ugeskrift for laeger, 2020, 07-27, Volume: 182, Issue:31

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis

2020
Challenges in the Treatment of Newly Diagnosed and Recurrent Primary Central Nervous System Lymphoma.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2020, Volume: 18, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Cranial Irradiation; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Retrospective Studies; Transplantation, Autologous

2020
Consolidation Treatment for Primary Central Nervous System Lymphoma: Which Modality for Whom?
    Acta haematologica, 2021, Volume: 144, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stem Cell Transplantation; Transplantation, Autologous; Treatment Outcome

2021
Central Nervous System Lymphomas.
    Continuum (Minneapolis, Minn.), 2020, Volume: 26, Issue:6

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Tumor Microenvironment

2020
High-dose methotrexate-based regimens and post-remission consolidation for treatment of newly diagnosed primary CNS lymphoma: meta-analysis of clinical trials.
    Scientific reports, 2021, 01-22, Volume: 11, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Dose-Response Relationship, Drug; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Remission Induction; Treatment Outcome

2021
Current progress and future perspectives of research on intravascular large B-cell lymphoma.
    Cancer science, 2021, Volume: 112, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Cell Cycle Checkpoints; Central Nervous System Neoplasms; Clinical Trials, Phase II as Topic; Cyclophosphamide; Doxorubicin; Female; Forecasting; Heterografts; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Transplantation; Prednisone; Programmed Cell Death 1 Ligand 2 Protein; Progression-Free Survival; Rituximab; Vascular Neoplasms; Vincristine

2021
Current management of primary central nervous system lymphoma.
    Chinese clinical oncology, 2017, Volume: 6, Issue:4

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Molecular Targeted Therapy; Rituximab

2017
Primary Central Nervous System Lymphoma.
    Continuum (Minneapolis, Minn.), 2017, Volume: 23, Issue:6, Neuro-o

    Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stem Cell Transplantation

2017
Therapy of primary CNS lymphoma: role of intensity, radiation, and novel agents.
    Hematology. American Society of Hematology. Education Program, 2017, 12-08, Volume: 2017, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autografts; Blood-Brain Barrier; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma; Methotrexate; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Rituximab; Stem Cell Transplantation; Thiotepa

2017
Secondary CNS relapse in diffuse large B-cell lymphoma: defining high-risk patients and optimization of prophylaxis strategies.
    Hematology. American Society of Hematology. Education Program, 2017, 12-08, Volume: 2017, Issue:1

    Topics: Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Models, Neurological; Neoplasm Recurrence, Local; Rituximab; Secondary Prevention

2017
Central Nervous System Involvement in Peripheral T Cell Lymphoma.
    Current hematologic malignancy reports, 2018, Volume: 13, Issue:1

    Topics: Autografts; Central Nervous System Neoplasms; Humans; Incidence; Lymphoma, T-Cell, Peripheral; Methotrexate; Stem Cell Transplantation

2018
Updates on Primary Central Nervous System Lymphoma.
    Current oncology reports, 2018, 02-28, Volume: 20, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Methotrexate; Randomized Controlled Trials as Topic

2018
Primary Central Nervous System Lymphoma-PART 2: Modern Therapeutic Management and Future Directions.
    Oncology (Williston Park, N.Y.), 2018, 02-15, Volume: 32, Issue:2

    Topics: Central Nervous System Neoplasms; Cranial Irradiation; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Transplantation, Autologous

2018
Neuromeningeal prophylaxis for diffuse large B-cell lymphoma.
    La Tunisie medicale, 2017, Volume: 95, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoprevention; Humans; Incidence; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Risk Factors

2017
How to Decide Which DLBCL Patients Should Receive CNS Prophylaxis.
    Oncology (Williston Park, N.Y.), 2018, Volume: 32, Issue:6

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Patient Selection; Prednisone; Risk Factors; Rituximab; Vincristine

2018
Central Nervous System Prophylaxis Strategies in Diffuse Large B Cell Lymphoma.
    Current treatment options in oncology, 2018, 09-10, Volume: 19, Issue:11

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rituximab; Vincristine

2018
Improving outcomes in primary CNS lymphoma.
    Best practice & research. Clinical haematology, 2018, Volume: 31, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate

2018
Is whole-brain radiotherapy still a standard treatment for primary central nervous system lymphomas?
    Current opinion in neurology, 2018, Volume: 31, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Radiotherapy

2018
Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.
    Neuro-oncology, 2019, 02-19, Volume: 21, Issue:3

    Topics: Age Factors; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Cytoreduction Surgical Procedures; Humans; Immunocompromised Host; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Methotrexate; Neoplasm Staging; Neurosurgical Procedures; Prognosis; Rituximab; Survival Rate

2019
Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.
    Current oncology reports, 2019, 03-27, Volume: 21, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Killer Cells, Natural; Leukemia, T-Cell; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis; T-Lymphocytes

2019
Primary central nervous system lymphoma: Novel precision therapies.
    Critical reviews in oncology/hematology, 2019, Volume: 141

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; High-Throughput Nucleotide Sequencing; Humans; Immunotherapy; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Molecular Targeted Therapy; Precision Medicine; Therapies, Investigational

2019
Aggressive Non-Hodgkin lymphomas: risk factors and treatment of central nervous system recurrence.
    Expert review of hematology, 2019, Volume: 12, Issue:9

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Risk Factors; Stem Cell Transplantation; Treatment Outcome

2019
[High-dose methotrexate plus hematopoietic stem cell transplantation supplemented by rituximab intrathecal injection for primary central nervous system lymphoma:two cases report and literature review].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2013, Volume: 34, Issue:2

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplantation; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Rituximab

2013
Development of JAK2V617F-positive polycythemia vera after chemotherapy-induced remission of primary central nervous system diffuse large B cell non-Hodgkin's lymphoma: a case report and review of the literature.
    Acta haematologica, 2013, Volume: 130, Issue:3

    Topics: Aged; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Humans; Janus Kinase 2; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Mutation, Missense; Polycythemia Vera

2013
Beyond high-dose methotrexate and brain radiotherapy: novel targets and agents for primary CNS lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2014, Volume: 25, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Humans; Lymphoma; Methotrexate; Phenotype; Tumor Microenvironment

2014
LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma.
    British journal of haematology, 2014, Volume: 165, Issue:5

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; DNA-Binding Proteins; Humans; Kaplan-Meier Estimate; LIM Domain Proteins; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neoplasm Proteins; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-6; Treatment Outcome

2014
Prophylactic CNS directed therapy in systemic diffuse large B cell lymphoma.
    Critical reviews in oncology/hematology, 2014, Volume: 91, Issue:3

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Prednisone; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Rituximab; Survival Analysis; Vincristine

2014
The role of additional radiotherapy for primary central nervous system lymphoma.
    The Cochrane database of systematic reviews, 2014, Jun-16, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Early Termination of Clinical Trials; Humans; Lymphoma; Methotrexate; Randomized Controlled Trials as Topic

2014
[Malignant lymphoma in the central nervous system: overview].
    Brain and nerve = Shinkei kenkyu no shinpo, 2014, Volume: 66, Issue:8

    Topics: Blood-Brain Barrier; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Positron-Emission Tomography

2014
[Primary central nervous lymphoma: what is the role for radiotherapy?].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2014, Volume: 18, Issue:7

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis; Radiotherapy Dosage; Radiotherapy, Adjuvant; Stem Cell Transplantation

2014
Haematopoietic stem cell transplantation for treatment of primary CNS lymphoma: single-centre experience and literature review.
    European journal of haematology, 2015, Volume: 95, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Retrospective Studies; Thiotepa; Transplantation, Autologous

2015
First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)--a systematic review and individual patient data meta-analysis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2015, Volume: 26, Issue:7

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Prognosis; Survival Rate

2015
Primary CNS lymphoma and neurologic complications of hematologic malignancies.
    Continuum (Minneapolis, Minn.), 2015, Volume: 21, Issue:2 Neuro-on

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Diagnosis, Differential; Hematologic Neoplasms; Humans; Leukemia; Lymphoma; Methotrexate

2015
Central Nervous System Prophylaxis for Aggressive B-cell Lymphoma: Who, What, and When?
    Hematology/oncology clinics of North America, 2016, Volume: 30, Issue:6

    Topics: Central Nervous System Neoplasms; Humans; Lymphoma, B-Cell; Magnetic Resonance Imaging; Methotrexate

2016
Extranodal lymphoma: a reappraisal.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19 Suppl 4

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Gastrointestinal Neoplasms; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Prednisone; Prospective Studies; Remission Induction; Retrospective Studies; Stem Cell Transplantation; Survival Analysis; Testicular Neoplasms; Treatment Outcome; Vincristine

2008
Primary central nervous system lymphoma: recent progress, many remaining questions.
    Current opinion in oncology, 2009, Volume: 21, Issue:5

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Rituximab

2009
Contralateral testicular relapse after prophylactic radiation in a patient with primary testicular diffuse large B-cell lymphoma.
    European journal of haematology, 2009, Dec-01, Volume: 83, Issue:6

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Blood-Testis Barrier; Bone Marrow; Carboplatin; Central Nervous System Neoplasms; Cyclophosphamide; Disease Progression; Doxorubicin; Etoposide; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Injections, Spinal; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Orchiectomy; Prednisone; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Salvage Therapy; Testicular Neoplasms; Transplantation Conditioning; Treatment Failure; Vincristine

2009
[Medical management of primary central nervous system lymphoma refractory or resistant to standard of care treatment].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dacarbazine; Drug Discovery; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Rituximab; Salvage Therapy; Temozolomide; Topotecan

2009
Treatment approaches for primary CNS lymphomas.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials, Phase II as Topic; Combined Modality Therapy; Cytarabine; Dose-Response Relationship, Drug; Humans; Lymphoma; Methotrexate; Prognosis; Radiotherapy; Randomized Controlled Trials as Topic; Stem Cell Transplantation

2010
[Treatment strategy for central nervous system involvement in intravascular large B-cell lymphoma].
    Brain and nerve = Shinkei kenkyu no shinpo, 2011, Volume: 63, Issue:5

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Prednisolone; Rituximab; Vascular Neoplasms; Vincristine

2011
Pharmacotherapy for primary CNS lymphoma: progress beyond methotrexate?
    CNS drugs, 2011, Jun-01, Volume: 25, Issue:6

    Topics: Central Nervous System Neoplasms; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stem Cell Transplantation

2011
[Management of primary central nervous system lymphoma].
    Revue neurologique, 2011, Volume: 167, Issue:10

    Topics: Adult; Aged; Aging; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Prognosis

2011
Primary central nervous system lymphoma: is there still a role for radiotherapy?
    Current opinion in neurology, 2011, Volume: 24, Issue:6

    Topics: Antimetabolites, Antineoplastic; Cell- and Tissue-Based Therapy; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Radiotherapy Dosage; Survival Rate; Treatment Outcome

2011
Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma.
    Leukemia & lymphoma, 2012, Volume: 53, Issue:10

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Drug Administration Schedule; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Treatment Outcome

2012
Combined modality therapy versus chemotherapy alone as an induction regimen for primary central nervous system lymphoma: a decision analysis.
    British journal of haematology, 2012, Volume: 158, Issue:5

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Decision Support Techniques; Humans; Infant; Life Expectancy; Lymphoma; Markov Chains; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Quality of Life; Quality-Adjusted Life Years; Remission Induction; Survival Analysis; Treatment Outcome; Young Adult

2012
Impact of central nervous system (CNS) prophylaxis on the incidence and risk factors for CNS relapse in patients with diffuse large B-cell lymphoma treated in the rituximab era: a single centre experience and review of the literature.
    British journal of haematology, 2012, Volume: 159, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Incidence; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Retrospective Studies; Risk Factors; Rituximab; Vincristine; Young Adult

2012
Primary CNS lymphoma: a clinician's guide.
    Expert review of neurotherapeutics, 2012, Volume: 12, Issue:10

    Topics: Adult; Age Factors; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Diagnosis, Differential; Evidence-Based Medicine; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis

2012
Role of chemotherapy additional to high-dose methotrexate for primary central nervous system lymphoma (PCNSL).
    The Cochrane database of systematic reviews, 2012, Nov-14, Volume: 11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Randomized Controlled Trials as Topic

2012
Pneumocystis carinii pneumonia prophylaxis in HIV negative patients with primary CNS lymphoma.
    Cancer treatment reviews, 2003, Volume: 29, Issue:2

    Topics: Antibiotic Prophylaxis; Antifungal Agents; Antimetabolites, Antineoplastic; CD4 Lymphocyte Count; Central Nervous System Neoplasms; Drug Interactions; HIV Seronegativity; Humans; Lymphoma; Methotrexate; Middle Aged; Pneumonia, Pneumocystis; Radiotherapy

2003
CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, May-01, Volume: 21, Issue:9

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome

2003
Primary central nervous system lymphomas.
    Current opinion in neurology, 2003, Volume: 16, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Humans; Immunocompromised Host; Lymphoma, B-Cell; Methotrexate; Radiotherapy; Survival Rate; Treatment Outcome

2003
Treatment of primary central nervous system lymphoma in the elderly.
    Seminars in oncology, 2003, Volume: 30, Issue:6 Suppl 19

    Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dementia; Humans; Lymphoma; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Survival Rate

2003
[Primary central nervous system lymphoma: diagnosis, management and current topics].
    No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Diagnosis, Differential; Humans; Immunocompetence; Lymphoma; Methotrexate; Nervous System Diseases; Radiotherapy Dosage

2004
Defining the appropriate dosage of folinic acid after high-dose methotrexate for childhood acute lymphatic leukemia that will prevent neurotoxicity without rescuing malignant cells in the central nervous system.
    Journal of pediatric hematology/oncology, 2004, Volume: 26, Issue:3

    Topics: Central Nervous System Neoplasms; Child; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Primary central nervous system lymphomas in immunocompetent patients.
    Histology and histopathology, 2004, Volume: 19, Issue:3

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, T-Cell; Magnetic Resonance Imaging; Methotrexate

2004
Advances for the treatment of primary central nervous system lymphoma (review).
    Oncology reports, 2004, Volume: 12, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Quality of Life; Recurrence; Time Factors; Treatment Outcome

2004
Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Brain Neoplasms; Central Nervous System Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Disease-Free Survival; Drug Evaluation; Drug Resistance, Neoplasm; Eye Neoplasms; Female; Humans; Immunotherapy; Life Tables; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies; Rituximab; Salvage Therapy; Survival Analysis; Temozolomide; Treatment Outcome

2004
Recent advances in primary CNS lymphoma.
    Current opinion in oncology, 2004, Volume: 16, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Radiotherapy, Adjuvant

2004
Controversies in primary CNS lymphoma.
    Expert review of neurotherapeutics, 2005, Volume: 5, Issue:4

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate

2005
[Treatment of central nervous system malignant lymphoma].
    No to shinkei = Brain and nerve, 2005, Volume: 57, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; HIV Infections; Humans; Lymphoma; Methotrexate

2005
Treatment of acute lymphoblastic leukemia.
    The New England journal of medicine, 2006, Jan-12, Volume: 354, Issue:2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Combined Modality Therapy; Dexamethasone; Gene Expression Profiling; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Assessment; Stem Cell Transplantation; Survival Analysis

2006
Clinical utility and pharmacology of high-dose methotrexate in the treatment of primary CNS lymphoma.
    Expert review of neurotherapeutics, 2006, Volume: 6, Issue:5

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Humans; Lymphoma; Methotrexate; Treatment Outcome

2006
Pharmacokinetic considerations in the treatment of CNS tumours.
    Clinical pharmacokinetics, 2006, Volume: 45, Issue:9

    Topics: Animals; Anthracyclines; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Camptothecin; Central Nervous System Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation, Preclinical; Humans; Methotrexate

2006
An update on therapy of primary central nervous system lymphoma.
    Hematology. American Society of Hematology. Education Program, 2006

    Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Survival Rate

2006
High-dose methotrexate and primary central nervous system lymphoma.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2007, Volume: 39, Issue:2

    Topics: Antimetabolites, Antineoplastic; Biopsy; Central Nervous System Neoplasms; Drug Administration Schedule; Drug Monitoring; Female; Humans; Incidence; Infection Control; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Nursing Assessment; Patient Care Planning; Rare Diseases; Stereotaxic Techniques; Survival Rate; Treatment Outcome

2007
Primary CNS lymphoma.
    Expert review of anticancer therapy, 2007, Volume: 7, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Central Nervous System Neoplasms; Combined Modality Therapy; HIV Infections; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis; Radiotherapy; Stem Cell Transplantation

2007
Primary central nervous system lymphoma.
    Seminars in radiation oncology, 2007, Volume: 17, Issue:3

    Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Remission Induction; Survival Rate

2007
[Optimal central nervous system directed therapy in childhood acute lymphoblastic leukemia.].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2007, Volume: 45, Issue:5

    Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Primary central nervous system lymphomas: salvage treatment after failure to high-dose methotrexate.
    Cancer letters, 2007, Dec-18, Volume: 258, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Drug Therapy; Humans; Lymphoma; Methotrexate; Salvage Therapy; Stem Cell Transplantation; Treatment Failure

2007
Recurrent breast cancer: presentation, diagnosis, and treatment.
    Seminars in oncology, 1993, Volume: 20, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Bone Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Palliative Care; Radiotherapy; Soft Tissue Neoplasms

1993
[Primary malignant non-Hodgkin's lymphomas of the central nervous system in immunocompetent patients: diagnostic, prognostic and therapeutic criteria].
    Pathologica, 1997, Volume: 89, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Diagnostic Imaging; Female; Humans; Immunocompetence; Immunophenotyping; Incidence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Radioisotope Teletherapy; Survival Analysis

1997
Therapeutic management of primary central nervous system lymphoma: lessons from prospective trials.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:8

    Topics: Adult; Age Factors; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Neoplasm Staging; Prognosis

2000
High-dose methotrexate in childhood all.
    Pediatric hematology and oncology, 2000, Volume: 17, Issue:8

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Disease-Free Survival; Drug Administration Schedule; Humans; Infusions, Intravenous; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Time Factors

2000
Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
    Hematology/oncology clinics of North America, 2000, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Germany; Humans; Immunophenotyping; Injections, Spinal; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Models, Theoretical; Multicenter Studies as Topic; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Remission Induction; Risk; Survival Rate; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome

2000
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
    Hematology/oncology clinics of North America, 2000, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Administration Schedule; Granulocyte Colony-Stimulating Factor; Humans; Immunization, Passive; Immunophenotyping; Infusions, Intravenous; Injections, Spinal; Karyotyping; Mercaptopurine; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk; Rituximab; Survival Analysis; Texas; Treatment Outcome; Vincristine

2000
Therapeutic management of refractory or relapsed primary central nervous system lymphomas.
    Annals of hematology, 2001, Volume: 80 Suppl 3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vincristine

2001
Diagnostic advances and new trends for the treatment of primary central nervous system lymphoma.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:10

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Quality of Life; Risk Factors; Survival Analysis

2002
CNS-directed therapy in childhood acute lymphoblastic leukaemia.
    British journal of haematology, 1992, Volume: 82, Issue:1

    Topics: Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1992

Trials

128 trial(s) available for methotrexate and Central Nervous System Neoplasm

ArticleYear
Continued-Maintenance Therapy with High-dose Methotrexate Improves Overall Survival of Patients with Primary Central Nervous System Lymphoma.
    The journal of medical investigation : JMI, 2021, Volume: 68, Issue:3.4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Retrospective Studies

2021
Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study.
    BMC cancer, 2022, Jan-13, Volume: 22, Issue:1

    Topics: Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Female; gamma-Glutamyl Hydrolase; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Recombinant Proteins

2022
Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial.
    Leukemia, 2022, Volume: 36, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Quality of Life; Rituximab; Thiotepa; Transplantation, Autologous

2022
Optimizing MATRix as remission induction in PCNSL: de-escalated induction treatment in newly diagnosed primary CNS lymphoma.
    BMC cancer, 2022, Sep-10, Volume: 22, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Quality of Life; Remission Induction; Thiotepa; Transplantation, Autologous

2022
Randomized phase III study of high-dose methotrexate and whole-brain radiotherapy with/without temozolomide for newly diagnosed primary CNS lymphoma: JCOG1114C.
    Neuro-oncology, 2023, 04-06, Volume: 25, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Brain; Central Nervous System Neoplasms; Disease-Free Survival; Humans; Lymphoma; Methotrexate; Temozolomide

2023
Multidrug chemotherapy, whole-brain radiation and cytarabine therapy for primary central nervous system lymphoma in elderly patients with dose modification based on geriatric assessment: study protocol for a phase II, multicentre, non-randomised study.
    BMJ open, 2023, 04-24, Volume: 13, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System; Central Nervous System Neoplasms; Clinical Trials, Phase II as Topic; Cytarabine; Humans; Lymphoma; Methotrexate; Multicenter Studies as Topic; Prospective Studies; Rituximab; Treatment Outcome; Vincristine

2023
Long-term Outcomes in Primary CNS Lymphoma After R-MVP and High-Dose Chemotherapy With Autologous Hematopoietic Stem Cell Transplant.
    Neurology, 2023, 08-15, Volume: 101, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Disease Progression; Hematopoietic Stem Cell Transplantation; Humans; Leukoencephalopathies; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Rituximab; Transplantation, Autologous; Vincristine

2023
Immunohistochemistry for c-myc and bcl-2 overexpression improves risk stratification in primary central nervous system lymphoma.
    Hematological oncology, 2020, Volume: 38, Issue:3

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Cytarabine; Disease Progression; Female; Follow-Up Studies; Humans; Immunohistochemistry; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Retrospective Studies; Risk Assessment; Survival Rate

2020
Impact of central nervous system (CNS) prophylaxis on the incidence of CNS relapse in patients with high-risk diffuse large B cell/follicular grade 3B lymphoma.
    Annals of hematology, 2020, Volume: 99, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Incidence; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Rituximab; Vincristine

2020
Treatment of HIV-associated primary CNS lymphoma with antiretroviral therapy, rituximab, and high-dose methotrexate.
    Blood, 2020, 11-05, Volume: 136, Issue:19

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Central Nervous System Neoplasms; Drug Therapy, Combination; Female; Follow-Up Studies; HIV; HIV Infections; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Rituximab; Survival Rate

2020
Twenty-year follow-up of a pilot/phase II trial on the Bonn protocol for primary CNS lymphoma.
    Neurology, 2020, 12-08, Volume: 95, Issue:23

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Humans; Injections, Intraventricular; Karnofsky Performance Status; Lymphoma; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Pilot Projects; Survival Analysis

2020
Impact of contemporary regimens on the outcomes and toxicity of primary CNS lymphoma: a single-center retrospective analysis of 73 patients.
    Journal of neuro-oncology, 2021, Volume: 151, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Rituximab; Survival Rate; Venous Thromboembolism

2021
MMSE is an independent prognostic factor for survival in primary central nervous system lymphoma.
    Journal of neuro-oncology, 2021, Volume: 152, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy, Adjuvant; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma; Male; Mental Status and Dementia Tests; Methotrexate; Middle Aged; Neurosurgical Procedures; Prognosis; Risk Factors; Rituximab

2021
A single institutional retrospective evaluation for younger patients with primary central nervous lymphomas on a modified R-MPV regimen followed by radiotherapy and high dose cytarabine.
    Journal of clinical and experimental hematopathology : JCEH, 2017, Oct-12, Volume: 57, Issue:2

    Topics: Aftercare; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Rituximab; Survival Rate

2017
[Curative Efficacy of High Dose MTX Combined with Rituxan for Treatment Primary CNS Lymphoma].
    Zhongguo shi yan xue ye xue za zhi, 2017, Volume: 25, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Rituximab; Treatment Outcome

2017
A prospective phase II trial of response adapted whole brain radiotherapy after high dose methotrexate based chemotherapy in patients with newly diagnosed primary central nervous system lymphoma-analysis of acute toxicity profile and early clinical outcom
    Journal of neuro-oncology, 2018, Volume: 139, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dose Fractionation, Radiation; Feasibility Studies; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Quality of Life; Treatment Outcome

2018
Impact of front line relative dose intensity for methotrexate and comorbidities in immunocompetent elderly patients with primary central nervous system lymphoma.
    Annals of hematology, 2018, Volume: 97, Issue:12

    Topics: Aged; Aged, 80 and over; Central Nervous System Neoplasms; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Survival Rate

2018
Fotemustine, teniposide and dexamethasone versus high-dose methotrexate plus cytarabine in newly diagnosed primary CNS lymphoma: a randomised phase 2 trial.
    Journal of neuro-oncology, 2018, Volume: 140, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Proto-Oncogene Proteins c-bcl-6; Teniposide; Treatment Outcome; Young Adult

2018
Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma.
    Blood, 2019, 01-31, Volume: 133, Issue:5

    Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Circulating Tumor DNA; Female; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rituximab; Treatment Outcome; Young Adult

2019
Rituximab in patients with primary CNS lymphoma (HOVON 105/ALLG NHL 24): a randomised, open-label, phase 3 intergroup study.
    The Lancet. Oncology, 2019, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Rituximab; Young Adult

2019
Characteristics, management and outcome of DLBCL patients, presenting with simultaneous systemic and CNS disease at diagnosis: A retrospective multicenter study.
    American journal of hematology, 2019, Volume: 94, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Survival Rate

2019
Outcomes of synchronous systemic and central nervous system (CNS) involvement of diffuse large B-cell lymphoma are dictated by the CNS disease: a collaborative study of the Australasian Lymphoma Alliance.
    British journal of haematology, 2019, Volume: 187, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Australia; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Rate; United Kingdom

2019
Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study.
    Pediatric blood & cancer, 2013, Volume: 60, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Europe; Follow-Up Studies; Humans; Japan; Lymphoma, Large-Cell, Anaplastic; Male; Methotrexate; Survival Rate

2013
Disseminated lymphoblastic lymphoma in children and adolescents: results of the COG A5971 trial: a report from the Children's Oncology Group.
    British journal of haematology, 2013, Volume: 162, Issue:6

    Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Cyclophosphamide; Disease-Free Survival; Female; Humans; Injections, Spinal; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Nov-01, Volume: 31, Issue:31

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Rituximab; Time; Treatment Outcome; Vincristine

2013
The role of radiotherapy and intrathecal CNS prophylaxis in extralymphatic craniofacial aggressive B-cell lymphomas.
    Blood, 2014, Jul-31, Volume: 124, Issue:5

    Topics: Adolescent; Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Disease-Free Survival; Facial Neoplasms; Female; Germany; Humans; Injections, Spinal; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Radiotherapy; Rituximab; Skull Neoplasms; Survival Rate

2014
A phase 1 dose escalation study of idarubicin combined with methotrexate, vindesine, and prednisolone for untreated elderly patients with primary central nervous system lymphoma. The GOELAMS LCP 99 trial.
    American journal of hematology, 2014, Volume: 89, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Idarubicin; Immunocompetence; Infections; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neutropenia; Palliative Care; Prednisolone; Recurrence; Remission Induction; Renal Insufficiency; Thrombocytopenia; Treatment Outcome; Vindesine

2014
Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report.
    British journal of haematology, 2014, Volume: 167, Issue:3

    Topics: Adolescent; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Burkitt Lymphoma; Central Nervous System Neoplasms; Child; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Genes, myc; Humans; Immunotherapy; Infusions, Intravenous; Kaplan-Meier Estimate; Lymphoma, B-Cell; Maintenance Chemotherapy; Male; Methotrexate; Prednisone; Remission Induction; Rituximab; Typhlitis; Vincristine

2014
Prognostic impact of intraocular involvement in primary CNS lymphoma: experience from the G-PCNSL-SG1 trial.
    Annals of hematology, 2015, Volume: 94, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Eye Diseases; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Young Adult

2015
Risk-tailored CNS prophylaxis in a mono-institutional series of 200 patients with diffuse large B-cell lymphoma treated in the rituximab era.
    British journal of haematology, 2015, Volume: 168, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Retrospective Studies; Risk Factors; Rituximab; Vincristine

2015
R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant for newly diagnosed primary CNS lymphoma.
    Blood, 2015, Feb-26, Volume: 125, Issue:9

    Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Procarbazine; Prognosis; Rituximab; Survival Rate; Thiotepa; Transplantation, Autologous; Vincristine; Young Adult

2015
Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma.
    Neurology, 2015, Mar-24, Volume: 84, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome

2015
Concomitant systemic and central nervous system non-Hodgkin lymphoma: the role of consolidation in terms of high dose therapy and autologous stem cell transplantation. A 60-case retrospective study from LYSA and the LOC network.
    Haematologica, 2015, Volume: 100, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anthracyclines; Autografts; Central Nervous System Neoplasms; Consolidation Chemotherapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Retrospective Studies; Stem Cell Transplantation; Survival Rate

2015
Journal Club: Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma.
    Neurology, 2015, Dec-15, Volume: 85, Issue:24

    Topics: Antineoplastic Agents; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate

2015
Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial.
    The Lancet. Haematology, 2015, Volume: 2, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Prospective Studies; Quality of Life; Temozolomide; Treatment Outcome; Vincristine

2015
Phase I and II Study of Induction Chemotherapy With Methotrexate, Rituximab, and Temozolomide, Followed By Whole-Brain Radiotherapy and Postirradiation Temozolomide for Primary CNS Lymphoma: NRG Oncology RTOG 0227.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, 05-10, Volume: 34, Issue:14

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Dacarbazine; Disease-Free Survival; Female; Humans; Induction Chemotherapy; Lymphoma; Male; Methotrexate; Middle Aged; Rituximab; Temozolomide; Whole-Body Irradiation; Young Adult

2016
Treatment of newly diagnosed B-cell origin primary CNS lymphoma with systemic R-IDARAM chemotherapy and intrathecal immunochemotherapy.
    Oncotarget, 2016, May-03, Volume: 7, Issue:18

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease-Free Survival; Female; Humans; Idarubicin; Immunotherapy; Injections, Spinal; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Pilot Projects; Rituximab; Treatment Outcome; Young Adult

2016
Rituximab and dose-dense chemotherapy for adults with Burkitt's lymphoma: a randomised, controlled, open-label, phase 3 trial.
    Lancet (London, England), 2016, Jun-11, Volume: 387, Issue:10036

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow Neoplasms; Burkitt Lymphoma; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Female; France; Humans; Hydrocortisone; Injections, Intravenous; Male; Methotrexate; Methylprednisolone; Middle Aged; Neoplasm Staging; Odds Ratio; Patient Selection; Prednisone; Proportional Hazards Models; Rituximab; Treatment Outcome; Vincristine

2016
High-dose chemotherapy and autologous stem cell transplant compared with conventional chemotherapy for consolidation in newly diagnosed primary CNS lymphoma--a randomized phase III trial (MATRix).
    BMC cancer, 2016, Apr-21, Volume: 16

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Etoposide; Female; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Stem Cell Transplantation; Thiotepa; Transplantation, Autologous

2016
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
    The Lancet. Haematology, 2016, Volume: 3, Issue:5

    Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Comparative Effectiveness Research; Cytarabine; Death, Sudden; Denmark; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Gastrointestinal Diseases; Germany; Heart Injuries; Hematopoietic Stem Cell Transplantation; Humans; Hyperglycemia; Induction Chemotherapy; Infections; Intraocular Lymphoma; Italy; Kaplan-Meier Estimate; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mucositis; Neurotoxicity Syndromes; Neutropenia; Optic Nerve Neoplasms; Poisoning; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Stroke; Switzerland; Thiotepa; Thrombocytopenia; Thrombosis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; United Kingdom

2016
Primary Oculocerebral Lymphoma: MTX Polychemotherapy Alone on Intraocular Disease Control.
    Ophthalmology, 2016, Volume: 123, Issue:9

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cerebellum; Cytarabine; Dacarbazine; Eye Neoplasms; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Procarbazine; Survival Analysis; Temozolomide; Vincristine

2016
[Clinical Therapeutic Efficacy of Rituximab Combined with Methotrexate on Primary Central Nervous System Lymphoma].
    Zhongguo shi yan xue ye xue za zhi, 2016, Volume: 24, Issue:2

    Topics: Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Quality of Life; Rituximab; Survival Rate; Treatment Outcome

2016
High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial.
    The Lancet. Haematology, 2016, Volume: 3, Issue:8

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Prospective Studies; Rituximab; Survival Rate; Thiotepa; Transplantation, Autologous; Young Adult

2016
Treatment of secondary central nervous system lymphoma with intrathecal rituximab, high-dose methotrexate, and R-DHAP followed by autologous stem cell transplantation: results of the HOVON 80 phase 2 study.
    Hematological oncology, 2017, Volume: 35, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cisplatin; Cytarabine; Dexamethasone; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Rituximab; Transplantation, Autologous; Young Adult

2017
Is risk of central nervous system (CNS) relapse related to adjuvant taxane treatment in node-positive breast cancer? Results of the CNS substudy in the intergroup Phase III BIG 02-98 Trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Docetaxel; Doxorubicin; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Taxoids; Treatment Failure

2008
High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:2

    Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Karnofsky Performance Status; Leukopenia; Lomustine; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Pilot Projects; Procarbazine; Proportional Hazards Models; Radiotherapy, Adjuvant; Survival Analysis; Thrombocytopenia; Time Factors; Treatment Outcome

2009
Long-term survival in primary CNS lymphoma treated by high-dose methotrexate monochemotherapy: role of STAT6 activation as prognostic determinant.
    Journal of neuro-oncology, 2009, Volume: 92, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Central Nervous System Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; STAT6 Transcription Factor

2009
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
    The New England journal of medicine, 2009, Jun-25, Volume: 360, Issue:26

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Dexamethasone; Hematopoietic Stem Cell Transplantation; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Secondary Prevention; Survival Analysis; Treatment Outcome; Vincristine

2009
High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial.
    Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Drug Administration Schedule; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Logistic Models; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Proportional Hazards Models; Remission Induction; Treatment Outcome

2009
Long-term follow-up of an age-adapted C5R protocol followed by radiotherapy in 99 newly diagnosed primary CNS lymphomas: a prospective multicentric phase II study of the Groupe d'Etude des Lymphomes de l'Adulte (GELA).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2010, Volume: 21, Issue:4

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Societies, Medical; Time Factors; Vincristine; Young Adult

2010
Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial.
    British journal of cancer, 2010, Feb-16, Volume: 102, Issue:4

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Central Nervous System Neoplasms; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; International Cooperation; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Survival Analysis; Treatment Outcome

2010
High-dose methotrexate and rituximab with deferred radiotherapy for newly diagnosed primary B-cell CNS lymphoma.
    Neuro-oncology, 2010, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Prospective Studies; Rituximab; Survival Rate; Young Adult

2010
CHOD/BVAM chemotherapy and whole-brain radiotherapy for newly diagnosed primary central nervous system lymphoma.
    International journal of radiation oncology, biology, physics, 2011, Oct-01, Volume: 81, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease Progression; Doxorubicin; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Radiotherapy Dosage; Remission Induction; Vincristine

2011
High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial.
    The Lancet. Oncology, 2010, Volume: 11, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chi-Square Distribution; Cranial Irradiation; Cytarabine; Disease-Free Survival; Dose Fractionation, Radiation; Female; Germany; Humans; Ifosfamide; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Survival Rate; Time Factors; Treatment Outcome

2010
Methotrexate- and/or cytarabine-based chemotherapy may be effective and safe in solid-organ transplant recipients with primary central nervous system lymphomas.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dose-Response Relationship, Drug; Feasibility Studies; Follow-Up Studies; Humans; Immunosuppression Therapy; Lymphoma; Methotrexate; Middle Aged; Organ Transplantation; Recurrence; Remission Induction; Transplantation; Treatment Outcome

2011
The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study.
    Pediatric blood & cancer, 2012, Volume: 58, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Cytarabine; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Remission Induction; Spinal Puncture; Survival Rate; Time Factors; Treatment Outcome

2012
Immunochemotherapy with rituximab, methotrexate, procarbazine, and lomustine for primary CNS lymphoma (PCNSL) in the elderly.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:9

    Topics: Age Factors; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Humans; Lomustine; Lymphoma, Non-Hodgkin; Male; Methotrexate; Pilot Projects; Procarbazine; Rituximab; Survival Analysis

2011
Clinical relevance of the dose of cytarabine in the upfront treatment of primary CNS lymphomas with methotrexate-cytarabine combination.
    The oncologist, 2011, Volume: 16, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Drug Administration Schedule; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Staging; Pilot Projects; Salvage Therapy; Survival Rate; Thiotepa

2011
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Jul-10, Volume: 29, Issue:20

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Recurrence; Rituximab; Survival Analysis; Testicular Neoplasms; Treatment Outcome; Vincristine

2011
High-dose methotrexate based chemotherapy with deferred radiation for treatment of newly diagnosed primary central nervous system lymphoma.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Methotrexate; Middle Aged; Procarbazine; Remission Induction; Survival Rate; Vincristine

2011
Methotrexate area under the curve as a prognostic factor in primary central nervous system lymphoma treated with immunochemoradiotherapy.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:10

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Karnofsky Performance Status; Male; Methotrexate; Middle Aged; Procarbazine; Prognosis; Rituximab; Survival Analysis; Vincristine

2011
The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI.
    Journal of hematology & oncology, 2011, Oct-13, Volume: 4

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Child, Preschool; Female; Humans; Infant; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Long-term follow-up of high-dose chemotherapy with autologous stem-cell transplantation and response-adapted whole-brain radiotherapy for newly diagnosed primary CNS lymphoma: results of the multicenter Ostdeutsche Studiengruppe Hamatologie und Onkologie
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Karnofsky Performance Status; Lymphoma; Male; Methotrexate; Middle Aged; Quality of Life; Stem Cell Transplantation; Transplantation, Autologous

2012
Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Feb-15, Volume: 18, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Consolidation Chemotherapy; Cytarabine; Dacarbazine; Diffusion Magnetic Resonance Imaging; Etoposide; Female; Humans; Immunotherapy; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Remission Induction; Rituximab; Survival Analysis; Temozolomide; Treatment Outcome

2012
Dose intensification of daunorubicin and cytarabine during treatment of adult acute lymphoblastic leukemia: results of Cancer and Leukemia Group B Study 19802.
    Cancer, 2013, Jan-01, Volume: 119, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Young Adult

2013
Outcome of elderly patients with primary CNS lymphoma in the G-PCNSL-SG-1 trial.
    Neurology, 2012, Aug-28, Volume: 79, Issue:9

    Topics: Age Factors; Aged; Antimetabolites; Central Nervous System Neoplasms; Combined Modality Therapy; Confidence Intervals; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Leukopenia; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Salvage Therapy; Survival Analysis; Watchful Waiting

2012
Central nervous system prophylaxis with high-dose methotrexate does not give rise to significant electroencephalographic changes in children with acute lymphoblastic leukemia.
    Journal of child neurology, 2002, Volume: 17, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Activity of postoperative carboplatin, etoposide, and high-dose methotrexate in pediatric CNS embryonal tumors: results of a phase II study in newly diagnosed children.
    Medical and pediatric oncology, 2002, Volume: 39, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Disease-Free Survival; Etoposide; Female; Humans; Infant; Male; Medulloblastoma; Methotrexate; Neoplasms, Germ Cell and Embryonal; Prognosis; Treatment Outcome

2002
Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-15, Volume: 21, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cerebrospinal Fluid; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Risk Factors; Spinal Puncture; Treatment Outcome

2003
Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol.
    Chemotherapy, 2003, Volume: 49, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Treatment Outcome; Vincristine

2003
Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jul-15, Volume: 21, Issue:14

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Belgium; Biopsy, Needle; Central Nervous System Neoplasms; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Spinal; Lomustine; Lymphoma; Male; Methotrexate; Methylprednisolone; Middle Aged; Multivariate Analysis; Neoplasm Staging; Probability; Procarbazine; Research; Risk Assessment; Survival Analysis; Treatment Outcome

2003
Primary central nervous system lymphoma: Phase I evaluation of infusional bromodeoxyuridine with whole brain accelerated fractionation radiation therapy after chemotherapy.
    Cancer, 2003, Sep-01, Volume: 98, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Bromodeoxyuridine; Central Nervous System Neoplasms; Cisplatin; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Female; Humans; Idarubicin; Infusions, Intravenous; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome

2003
Comparable outcomes of radiation therapy without high-dose methotrexate for patients with primary central nervous system lymphoma.
    Japanese journal of clinical oncology, 2003, Volume: 33, Issue:9

    Topics: Adult; Aged; Central Nervous System Neoplasms; Cranial Irradiation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Radiotherapy Dosage; Retrospective Studies; Spinal Cord; Survival Rate; Treatment Outcome

2003
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Dec-15, Volume: 21, Issue:24

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Humans; Lymphoma; Male; Methotrexate; Methylprednisolone; Middle Aged; Prospective Studies; Survival Analysis; Teniposide; Treatment Outcome

2003
Primary central nervous system lymphoma: results of a pilot and phase II study of systemic and intraventricular chemotherapy with deferred radiotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Dec-15, Volume: 21, Issue:24

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Female; Humans; Ifosfamide; Lymphoma; Male; Methotrexate; Middle Aged; Pilot Projects; Prednisolone; Survival Analysis; Treatment Outcome

2003
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172).
    British journal of haematology, 2004, Volume: 124, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Humans; Infant; Leukocyte Count; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2004
The development of targeted chemotherapy for CNS lymphoma-a pilot study of the IDARAM regimen.
    Cancer chemotherapy and pharmacology, 2004, Volume: 53, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Idarubicin; Lymphoma; Male; Methotrexate; Middle Aged; Pilot Projects; United Kingdom

2004
Area under the curve of methotrexate and creatinine clearance are outcome-determining factors in primary CNS lymphomas.
    British journal of cancer, 2004, Jan-26, Volume: 90, Issue:2

    Topics: Adult; Age Factors; Aged; Anticonvulsants; Antimetabolites, Antineoplastic; Area Under Curve; Central Nervous System Neoplasms; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies

2004
Intensive chemotherapy with and without cranial radiation for Burkitt leukemia and lymphoma: final results of Cancer and Leukemia Group B Study 9251.
    Cancer, 2004, Apr-01, Volume: 100, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Female; Humans; Male; Methotrexate; Middle Aged; Survival Analysis; Treatment Outcome

2004
Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma.
    British journal of haematology, 2005, Volume: 128, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Female; Humans; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Survival Rate; Treatment Outcome

2005
Chemoradiotherapy for primary CNS lymphoma: an intent-to-treat analysis with complete follow-up.
    Neurology, 2005, Jan-11, Volume: 64, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Prospective Studies; Survival Rate; Thiotepa; Treatment Outcome

2005
High-dose methotrexate toxicity in elderly patients with primary central nervous system lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Glomerular Filtration Rate; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome

2005
Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.
    Pediatric blood & cancer, 2005, Volume: 44, Issue:5

    Topics: Antineoplastic Agents; Attention; Central Nervous System Neoplasms; Child; Cognition Disorders; Contraindications; Female; Humans; Injections, Spinal; Male; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Tests; Radiotherapy; Survivors

2005
Combined-modality therapy for primary central nervous system lymphoma: long-term data from a Phase II multicenter study (Trans-Tasman Radiation Oncology Group).
    International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2

    Topics: Adult; Age Factors; Aged; Antimetabolites, Antineoplastic; Ataxia; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Humans; Lymphoma; Methotrexate; Middle Aged

2006
Systemic high-dose intravenous methotrexate for central nervous system metastases.
    Journal of neuro-oncology, 2006, Volume: 78, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Retrospective Studies; Survival Analysis; Treatment Outcome

2006
Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.
    Blood, 2006, Jul-15, Volume: 108, Issue:2

    Topics: Adolescent; Adult; Asparaginase; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate

2006
Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemi
    Blood, 2006, Aug-15, Volume: 108, Issue:4

    Topics: Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Risk Factors; Sex Factors; T-Lymphocytes; Testicular Neoplasms; Time Factors

2006
MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas.
    Neurology, 2006, May-09, Volume: 66, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Hematologic Diseases; Humans; Idarubicin; Life Tables; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Remission Induction; Stroke; Survival Analysis; Thiotepa

2006
High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Aug-20, Volume: 24, Issue:24

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Cranial Irradiation; Cytarabine; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Germany; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Thiotepa; Transplantation, Autologous; Treatment Outcome

2006
High-dose chemotherapy with autologous stem cell transplantation as first-line therapy for primary CNS lymphoma in patients younger than 60 years: a multicenter phase II study of the GOELAMS group.
    Bone marrow transplantation, 2006, Volume: 38, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Lymphoma; Male; Methotrexate; Methylprednisolone; Middle Aged; Remission Induction; Stem Cell Transplantation; Transplantation, Autologous

2006
Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:6

    Topics: Adult; Aged; Central Nervous System Neoplasms; Creatinine; Female; Humans; Kidney Function Tests; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Retrospective Studies

2007
Very high-dose methotrexate (33.6 g/m(2)) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P.
    Leukemia & lymphoma, 2006, Volume: 47, Issue:12

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Female; Humans; Infant; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Treatment Outcome

2006
Primary central nervous system lymphoma treated with high-dose methotrexate, high-dose busulfan/thiotepa, autologous stem-cell transplantation and response-adapted whole-brain radiotherapy: results of the multicenter Ostdeutsche Studiengruppe Hamato-Onkol
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Peripheral Blood Stem Cell Transplantation; Thiotepa

2007
Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201.
    Blood, 2007, Aug-15, Volume: 110, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Cell Lineage; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

2007
Immuno-chemotherapy with a combination of rituximab, methotrexate, pirarubicin and procarbazine for patients with primary CNS lymphoma--a preliminary report.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:5

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Doxorubicin; Female; Humans; Immunotherapy; Lymphoma; Male; Methotrexate; Middle Aged; Pilot Projects; Procarbazine; Rituximab

2007
Salvage therapy and late neurotoxicity in patients with recurrent primary CNS lymphoma treated with a modified ProMACE-MOPP hybrid regimen.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lymphoma; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neurotoxicity Syndromes; Prednisone; Procarbazine; Retrospective Studies; Salvage Therapy; Survival Analysis; Vincristine

2007
Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly.
    Journal of neuro-oncology, 2007, Volume: 85, Issue:2

    Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Dacarbazine; Drug Administration Schedule; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Temozolomide; Treatment Outcome

2007
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:9

    Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors

2007
Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Nov-01, Volume: 25, Issue:31

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Female; Glucocorticoids; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Intraarterial chemotherapy and osmotic blood-brain barrier disruption for patients with embryonal and germ cell tumors of the central nervous system.
    Cancer, 2008, Feb-01, Volume: 112, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Carboplatin; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Disease Progression; Etoposide; Female; Humans; Infant; Infusions, Intra-Arterial; Male; Methotrexate; Middle Aged; Neoplasms, Germ Cell and Embryonal; Prospective Studies; Survival Analysis; Treatment Outcome

2008
Primary central nervous system lymphoma: monocenter, long-term, intent-to-treat analysis.
    Cancer, 2008, Apr-15, Volume: 112, Issue:8

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Disease Progression; Disease-Free Survival; Feasibility Studies; Female; Follow-Up Studies; Humans; Karnofsky Performance Status; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies; Survival Rate; Treatment Outcome

2008
Renal dysfunction during and after high-dose methotrexate.
    Cancer chemotherapy and pharmacology, 2009, Volume: 63, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Case-Control Studies; Central Nervous System Neoplasms; Creatinine; Dose-Response Relationship, Drug; Female; gamma-Glutamyl Hydrolase; Humans; Kidney; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult

2009
Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
    Cancer, 1995, May-15, Volume: 75, Issue:10

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Central Nervous System Neoplasms; Child; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

1995
Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukaemia.
    Lancet (London, England), 1995, Jan-21, Volume: 345, Issue:8943

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Sex Factors; Survival Rate; Treatment Outcome; United Kingdom

1995
Preirradiation chemotherapy including "eight drugs in 1 day" regimen and high-dose methotrexate in childhood medulloblastoma: results of the M7 French Cooperative Study.
    Journal of neurosurgery, 1995, Volume: 82, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cognition Disorders; Combined Modality Therapy; Disease-Free Survival; Feasibility Studies; Female; Humans; Infant; Male; Medulloblastoma; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Remission Induction; Survival Analysis

1995
Stage III abdominal non-Hodgkin's lymphoma in Costa Rican children: comparison of two consecutive trials of treatment.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:3

    Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Costa Rica; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Infusions, Intravenous; Leucovorin; Life Tables; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Prospective Studies; Remission Induction; Survival Rate; Vincristine

1994
Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: a Childrens Cancer Group report.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survival Analysis

1993
Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients.
    Neurology, 1996, Volume: 46, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Eye Neoplasms; Female; Follow-Up Studies; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Procarbazine; Thiotepa; Tomography, X-Ray Computed; Vincristine

1996
PROMACE-MOPP and intrathecal chemotherapy for CNS lymphomas.
    Journal of neuro-oncology, 1996, Volume: 28, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Mechlorethamine; Methotrexate; Middle Aged; Neurologic Examination; Prednisone; Procarbazine; Steroids; Survival Analysis; Vincristine

1996
Preliminary results of combined chemotherapy and radiotherapy for non-AIDS primary central nervous system lymphoma. Trans-Tasman Radiation Oncology Group (TROG).
    The Medical journal of Australia, 1996, Oct-21, Volume: 165, Issue:8

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Australia; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Humans; Infusions, Intravenous; Lymphoma; Methotrexate; New Zealand; Prospective Studies; Survival Rate

1996
Intravenous methotrexate for primary central nervous system non-Hodgkin's lymphoma in AIDS.
    AIDS (London, England), 1997, Nov-15, Volume: 11, Issue:14

    Topics: Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Injections, Intravenous; Karnofsky Performance Status; Lymphoma, AIDS-Related; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Pilot Projects; Prospective Studies

1997
Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Remission Induction; Survival Analysis

1998
Phase II trial of chemotherapy alone for primary CNS and intraocular lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Drug Administration Schedule; Eye Neoplasms; Female; Humans; Leucovorin; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Pilot Projects; Thiotepa; Vincristine

1998
Improvement in CNS protective treatment in non-high-risk childhood acute lymphoblastic leukemia: report from the Japanese Children's Cancer and Leukemia Study Group.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Infant; Injections, Spinal; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Treatment Outcome

1999
Intravenous methotrexate as initial treatment for primary central nervous system lymphoma: response to therapy and quality of life of patients.
    Journal of neuro-oncology, 1999, Volume: 43, Issue:3

    Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Drug Administration Schedule; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Remission Induction; Surveys and Questionnaires; Survival Analysis

1999
Survival improvement with combined radio-chemotherapy in the primary central nervous system lymphomas.
    Journal of Korean medical science, 1999, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Epirubicin; Female; Humans; Lymphoma; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prednisolone; Procarbazine; Radiotherapy Dosage; Radiotherapy, Adjuvant; Survival Rate; Treatment Failure; Vincristine

1999
[Prevention of neuroleukemia by intrathecal administration of cytosar and methotrexate in acute lymphoblastic leukemia in adults].
    Terapevticheskii arkhiv, 1999, Volume: 71, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Immunophenotyping; Injections, Spinal; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors; Treatment Outcome

1999
Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia: the
    Cancer, 2000, Jan-01, Volume: 88, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Israel; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Risk; Treatment Outcome

2000
Phase II multicenter study of brief single-agent methotrexate followed by irradiation in primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infusions, Intravenous; Lymphoma; Male; Methotrexate; Middle Aged; Patient Compliance; Survival Analysis

2000
Outcome of CNS disease at diagnosis in disseminated small noncleaved-cell lymphoma and B-cell leukemia: a Children's Cancer Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Humans; Infant; Leukemia, B-Cell; Lymphoma, Non-Hodgkin; Male; Methotrexate; Prednisone; Proportional Hazards Models; Survival Analysis; Treatment Outcome; Vincristine

2000
Treatment for primary CNS lymphoma: the next step.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Female; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Nervous System Diseases; Procarbazine; Radiation Injuries; Survival Analysis; Vincristine

2000
Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Feb-01, Volume: 19, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Disease-Free Survival; Dose-Response Relationship, Drug; Etoposide; Eye Neoplasms; Feasibility Studies; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Nervous System Diseases; Salvage Therapy; Thiotepa

2001
CHOD/BVAM regimen plus radiotherapy in patients with primary CNS non-Hodgkin's lymphoma.
    International journal of radiation oncology, biology, physics, 2001, Jun-01, Volume: 50, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Survival Rate; Vincristine

2001
Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jan-01, Volume: 20, Issue:1

    Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Diseases; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Radiotherapy Dosage; Spain; Survival Rate; United Kingdom; Vincristine

2002
German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma.
    Annals of neurology, 2002, Volume: 51, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Disease-Free Survival; Humans; Lymphoma; Methotrexate; Middle Aged; Multivariate Analysis; Prospective Studies; Treatment Outcome

2002
Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Feasibility Studies; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Recurrence; Survival Analysis; Treatment Outcome

2002
Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Jun-15, Volume: 20, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Cytarabine; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infusions, Intravenous; Injections, Spinal; Male; Methotrexate; Palliative Care; Prognosis; Risk Factors; Treatment Outcome; Vincristine

2002
Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study.
    Leukemia, 1992, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Erythrocytes; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Prednisone; Recurrence; Remission Induction; Rosette Formation; Thioguanine; Treatment Outcome; Vincristine

1992

Other Studies

364 other study(ies) available for methotrexate and Central Nervous System Neoplasm

ArticleYear
Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions.
    Blood, 2022, 01-20, Volume: 139, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Treatment Outcome; Young Adult

2022
Comparative Molecular Analysis of Primary Central Nervous System Lymphomas and Matched Vitreoretinal Lymphomas by Vitreous Liquid Biopsy.
    International journal of molecular sciences, 2021, Sep-16, Volume: 22, Issue:18

    Topics: Central Nervous System Neoplasms; Eye Neoplasms; High-Throughput Nucleotide Sequencing; Humans; Liquid Biopsy; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Retinal Neoplasms; Rituximab; Vitreous Body

2021
A Retrospective Analysis of R-MPV Plus Response-adapted Whole-brain Radiotherapy for Elderly Patients with Primary Central Nervous System Lymphoma.
    Internal medicine (Tokyo, Japan), 2022, May-01, Volume: 61, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Treatment Outcome

2022
Rituximab, Methotrexate, Carmustine, Etoposide, and Prednisone (RMBVP) for the treatment of relapsed/refractory primary central nervous system lymphoma: a retrospective single-center study.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System; Central Nervous System Neoplasms; Etoposide; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Retrospective Studies; Rituximab

2022
Parameters of MR perfusion-weighted imaging predict the response and prognosis to high-dose methotrexate-based chemotherapy in immunocompetent patients with primary central nervous system lymphoma.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2022, Volume: 95

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Perfusion; Prognosis; Vascular Endothelial Growth Factor A

2022
Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation.
    Cells, 2021, 12-02, Volume: 10, Issue:12

    Topics: Animals; Apoptosis; Boron; Boron Neutron Capture Therapy; Brain; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Cranial Irradiation; Disease Models, Animal; Humans; Lymphoma; Methotrexate; Mice; Phenylalanine; Tissue Distribution

2021
Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients.
    Blood, 2022, 04-21, Volume: 139, Issue:16

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Retrospective Studies; Rituximab; Vincristine

2022
Outcome of Primary Central Nervous System Lymphoma Treated with Combined Surgical Resection and High- Dose Methotrexate Chemotherapy: A Single-Institution Retrospective Study.
    Turkish neurosurgery, 2022, Volume: 32, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Retrospective Studies; Treatment Outcome

2022
Tirabrutinib maintenance therapy for a patient with high-dose methotrexate-ineligible primary central nervous system lymphoma.
    Annals of hematology, 2022, Volume: 101, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Imidazoles; Lymphoma; Methotrexate; Pyrimidines

2022
Unusual primary central nervous system T-cell/histiocyte-rich large B-cell lymphoma: a case report.
    BMJ case reports, 2022, Feb-08, Volume: 15, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Female; Histiocytes; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Rituximab; T-Lymphocytes

2022
Role of upfront autologous stem cell transplantation in patients newly diagnosed with primary CNS lymphoma treated with R-MVP: real-world data from a retrospective single-center analysis.
    Bone marrow transplantation, 2022, Volume: 57, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Rituximab; Transplantation, Autologous

2022
Isolated CNS relapse of blastic plasmacytoid dendritic cell neoplasm.
    Blood, 2022, 02-24, Volume: 139, Issue:8

    Topics: Adult; Central Nervous System Neoplasms; Dendritic Cells; Hematologic Neoplasms; Humans; Injections, Spinal; Male; Methotrexate; Myeloproliferative Disorders; Recurrence

2022
High-dose methotrexate and rituximab induction regimen in immunocompetent patients with primary CNS lymphoma: a retrospective single-center study of survival predictors.
    Journal of neuro-oncology, 2022, Volume: 158, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Prospective Studies; Retrospective Studies; Rituximab

2022
Improving the outcomes of secondary CNS lymphoma with high-dose thiotepa, busulfan, melphalan, rituximab conditioning and autotransplant.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Autografts; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Melphalan; Methotrexate; Middle Aged; Neoplasms, Second Primary; Retrospective Studies; Rituximab; Thiotepa; Transplantation, Autologous; Treatment Outcome; Young Adult

2022
Rituximab, methotrexate, procarbazine and lomustine (R-MPL) for the treatment of primary Central nervous system lymphoma.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Lomustine; Lymphoma; Methotrexate; Middle Aged; Procarbazine; Receptors, Thrombopoietin; Rituximab

2022
Chemotherapy is an efficient treatment in primary CNS MALT lymphoma.
    Journal of neuro-oncology, 2022, Volume: 159, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma, B-Cell, Marginal Zone; Male; Methotrexate; Middle Aged; Retrospective Studies

2022
Consolidation regimens in primary central nervous system lymphoma: a single-center retrospective cohort evaluating survival outcomes and cost-benefit analysis.
    Journal of neuro-oncology, 2022, Volume: 159, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cost-Benefit Analysis; Cytarabine; Humans; Lymphoma; Methotrexate; Retrospective Studies

2022
Outcome and prognostic factors of very old patients with primary CNS lymphoma: a retrospective analysis of patients ≥80 years treated with high-dose methotrexate-based chemotherapy.
    Leukemia & lymphoma, 2022, Volume: 63, Issue:12

    Topics: Activities of Daily Living; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Methotrexate; Prognosis; Retrospective Studies; Treatment Outcome

2022
Experience With Tirabrutinib in the Treatment of Primary Central Nervous System Lymphoma that Is Difficult to Treat With Standard Treatment.
    Anticancer research, 2022, Volume: 42, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Cranial Irradiation; Female; Humans; Imidazoles; Lymphoma, Non-Hodgkin; Male; Methotrexate; Pyrimidines; Retrospective Studies

2022
Analysis of Key Factors Associated with Response to Salvage High-Dose Methotrexate Rechallenge in Primary Central Nervous System Lymphoma with First Relapse.
    Current oncology (Toronto, Ont.), 2022, 09-17, Volume: 29, Issue:9

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Quality of Life; Retrospective Studies; Salvage Therapy

2022
[Molecular pathogenesis and therapeutic development of primary central nervous system lymphoma: update and future perspectives].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2022, Volume: 63, Issue:9

    Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Humans; Immune Checkpoint Inhibitors; Lymphoma, Non-Hodgkin; Methotrexate; Myeloid Differentiation Factor 88; NF-kappa B; Phosphatidylinositol 3-Kinases; Procarbazine; Receptors, Chimeric Antigen; Rituximab; Thiotepa; Vincristine

2022
The role of whole-brain radiotherapy (WBRT) in primary central nervous system lymphoma: is it an alternative to ASCT for consolidation following HD-methotrexate based induction in low-income settings?
    Radiation oncology (London, England), 2022, Oct-22, Volume: 17, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Methotrexate; Rituximab; Stem Cell Transplantation; Thiotepa; Transplantation, Autologous

2022
About time: why central nervous system prophylaxis timing in diffuse large B-cell lymphoma matters and does the protocol need updating?
    Expert review of hematology, 2022, Volume: 15, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cyclophosphamide; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Rituximab

2022
Primary Central Nervous System Lymphoma: Clinical Characteristics, Treatment Options and Therapeutic Outcome in 36 Patients. A Single Center Experience.
    The Israel Medical Association journal : IMAJ, 2022, Volume: 24, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome

2022
Cranial Radiation Therapy as Salvage in the Treatment of Relapsed Primary CNS Lymphoma.
    Current oncology (Toronto, Ont.), 2022, 10-28, Volume: 29, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma; Methotrexate; Middle Aged; Retrospective Studies

2022
Methotrexate, cytarabine, thiotepa and rituximab (MATRix) chemoimmunotherapy for primary central nervous system lymphoma: a Toronto experience.
    Haematologica, 2023, 04-01, Volume: 108, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma; Methotrexate; Rituximab; Thiotepa

2023
CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.
    Cancer medicine, 2023, Volume: 12, Issue:6

    Topics: CD79 Antigens; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Mutation; Myeloid Differentiation Factor 88; Rituximab

2023
Rituximab with high-dose methotrexate is effective and cost-effective in newly diagnosed primary central nervous system lymphoma.
    Scientific reports, 2022, 12-13, Volume: 12, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cost-Benefit Analysis; Cytarabine; Humans; Lymphoma; Methotrexate; Retrospective Studies; Rituximab; Treatment Outcome

2022
Long-term outcomes of combined intravitreal methotrexate and systemic high-dose methotrexate therapy in vitreoretinal lymphoma.
    Cancer medicine, 2023, Volume: 12, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Eye Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Retinal Neoplasms; Retrospective Studies; Treatment Outcome; Vitreous Body

2023
Diagnosis, treatment, and prognosis of primary intraocular lymphoma: Single-center real-world clinical experience.
    Cancer medicine, 2023, Volume: 12, Issue:7

    Topics: Central Nervous System Neoplasms; Humans; Interleukin-10; Interleukin-6; Intraocular Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Retrospective Studies; Treatment Outcome

2023
Safety and efficacy of induction immunochemotherapy with rituximab, methotrexate, ifosfamide, and vincristine (R-MIV) in patients with primary CNS lymphoma including recent COVID-19 pandemic experience.
    British journal of haematology, 2023, Volume: 201, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; COVID-19; Cytarabine; Humans; Ifosfamide; Lymphoma; Methotrexate; Pandemics; Prospective Studies; Rituximab; SARS-CoV-2; Vincristine

2023
Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers.
    American journal of hematology, 2023, Volume: 98, Issue:6

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Temozolomide

2023
Primary Central Nervous System Lymphoma in an Immunocompetent Young Adult Patient: A Rare Case.
    Acta medica Indonesiana, 2023, Volume: 55, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Humans; Immunoglobulin G; Immunoglobulin M; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Procarbazine; Young Adult

2023
Impact of triple intrathecal prophylaxis in acute lymphoblastic leukemia adults receiving HyperCVAD: A COVID-19 practice change.
    European journal of haematology, 2023, Volume: 111, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; COVID-19; Cyclophosphamide; Humans; Methotrexate; Pandemics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Vincristine

2023
Diffuse large B-cell lymphoma at risk of secondary CNS involvement: The inefficacy of intravenous high-dose methotrexate CNS prophylaxis and the importance of baseline cerebrospinal fluid analysis.
    American journal of hematology, 2023, Volume: 98, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies

2023
[A single-center, retrospective analysis of relapse and progression patterns of primary central nervous system lymphoma: can whole brain radiotherapy be replaced?]
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023, Apr-20, Volume: 43, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Retrospective Studies

2023
Cerebral delivery of redox-responsive lenalidomide prodrug plus methotrexate for primary central nerve system lymphoma combination therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2023, Volume: 359

    Topics: Brain Neoplasms; Central Nervous System Neoplasms; Humans; Lenalidomide; Lymphoma; Methotrexate; Oxidation-Reduction; Prodrugs

2023
Management of primary and secondary CNS lymphoma.
    Hematological oncology, 2023, Volume: 41 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local; Prospective Studies; Transplantation, Autologous

2023
Brain radiotherapy in patients treated for a newly diagnosed primary central nervous system lymphoma: professional practice evaluation in 19 French centers.
    Acta oncologica (Stockholm, Sweden), 2023, Volume: 62, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Retrospective Studies

2023
Treatment of new-onset primary central nervous system lymphoma in elderly patients using RMPV chemotherapy: a single-institution experience.
    International journal of hematology, 2023, Volume: 118, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma; Methotrexate; Retrospective Studies; Rituximab; Treatment Outcome; Vincristine

2023
[Risk assessment and prophylactic treatment strategies for central nervous system relapse of diffuse large B-cell lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2023, Volume: 64, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Chronic Disease; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prednisone; Risk Assessment; Rituximab; Vincristine

2023
Eyewash with balanced salt solution after intravitreal methotrexate injection in a case of vitreoretinal lymphoma: a simple but effective way to prevent ocular surface toxicity.
    BMJ case reports, 2023, Jul-19, Volume: 16, Issue:7

    Topics: Central Nervous System Neoplasms; Corneal Diseases; Eye Neoplasms; Humans; Intravitreal Injections; Lymphoma, Non-Hodgkin; Methotrexate; Retinal Neoplasms; Sodium Chloride; Vitreous Body

2023
Factors Influencing Physician Discretion to Administer CNS Prophylaxis in Diffuse Large B Cell Lymphoma: A Single Institution Retrospective Study.
    Clinical lymphoma, myeloma & leukemia, 2023, Volume: 23, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies

2023
First-line induction chemotherapy with high-dose methotrexate versus teniposide in patients with newly diagnosed primary central nervous system lymphoma: a retrospective, multicenter cohort study.
    BMC cancer, 2023, Aug-11, Volume: 23, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Induction Chemotherapy; Lymphoma; Methotrexate; Retrospective Studies; Teniposide

2023
High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023, Dec-10, Volume: 41, Issue:35

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma; Lymphoma, B-Cell; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Young Adult

2023
Residual diffusion-weighted imaging hyperintense signal in primary central nervous system lymphoma can predict early recurrence.
    Journal of neuro-oncology, 2023, Volume: 165, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma; Methotrexate; Middle Aged; Retrospective Studies; Rituximab

2023
Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells.
    BMC cancer, 2019, Sep-11, Volume: 19, Issue:1

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2019
White matter changes in primary central nervous system lymphoma patients treated with high-dose methotrexate with or without rituximab.
    Journal of neuro-oncology, 2019, Volume: 145, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; White Matter

2019
Systemic high-dose intravenous methotrexate in patients with central nervous system metastatic breast cancer.
    BMC cancer, 2019, Nov-01, Volume: 19, Issue:1

    Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Neoplasms; Drug Administration Schedule; Drug Dosage Calculations; Female; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Survival Analysis

2019
Contrast-Enhanced MRI Texture Parameters as Potential Prognostic Factors for Primary Central Nervous System Lymphoma Patients Receiving High-Dose Methotrexate-Based Chemotherapy.
    Contrast media & molecular imaging, 2019, Volume: 2019

    Topics: Adult; Aged; Central Nervous System Neoplasms; Contrast Media; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies

2019
Preparation and Characterization of Fe
    International journal of nanomedicine, 2019, Volume: 14

    Topics: 3T3 Cells; Animals; Apoptosis; Cell Line, Tumor; Central Nervous System Neoplasms; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Female; Ferric Compounds; Humans; Hyperthermia, Induced; Lymphoma; Magnetite Nanoparticles; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Temperature; Toxicity Tests, Acute

2019
Patient selection and tolerability of high-dose methotrexate as central nervous system prophylaxis in diffuse large B-cell lymphoma.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:1

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Patient Selection; Prognosis; Retrospective Studies; Survival Rate

2020
Lateral intraventricular primary central nervous system lymphoma (LIPCNSL): a review.
    QJM : monthly journal of the Association of Physicians, 2020, Jul-01, Volume: 113, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; China; Craniotomy; Disease Progression; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy; Retrospective Studies; Salvage Therapy; Survival Analysis; Treatment Outcome; Young Adult

2020
Management and outcome of primary CNS lymphoma in the modern era: An LOC network study.
    Neurology, 2020, 03-10, Volume: 94, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Databases, Factual; France; Humans; Lymphoma; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Progression-Free Survival; Retrospective Studies; Rituximab; Stem Cell Transplantation; Transplantation, Autologous; Young Adult

2020
Cost-effectiveness analysis of rituximab with methotrexate, cytarabine and thiotepa for the treatment of patients with primary central nervous system lymphoma.
    Leukemia & lymphoma, 2020, Volume: 61, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Canada; Central Nervous System; Central Nervous System Neoplasms; Cost-Benefit Analysis; Cytarabine; Humans; Methotrexate; Rituximab; Thiotepa

2020
Induction therapy with the MATRix regimen in patients with newly diagnosed primary diffuse large B-cell lymphoma of the central nervous system - an international study of feasibility and efficacy in routine clinical practice.
    British journal of haematology, 2020, Volume: 189, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Comorbidity; Consolidation Chemotherapy; Cranial Irradiation; Cytarabine; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunotherapy; Induction Chemotherapy; Internationality; Kaplan-Meier Estimate; Lymphoma, AIDS-Related; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Organ Transplantation; Postoperative Complications; Progression-Free Survival; Proportional Hazards Models; Rituximab; Thiotepa

2020
Bilateral Infiltrative Optic Neuropathy of Systemic Mantle Cell Lymphoma.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Central Nervous System Neoplasms; Cytarabine; Fundus Oculi; Humans; Lymphoma, Mantle-Cell; Male; Methotrexate; Optic Nerve; Optic Nerve Diseases; Rituximab

2020
Comparison of Body Size, Morphomics, and Kidney Function as Covariates of High-Dose Methotrexate Clearance in Obese Adults with Primary Central Nervous System Lymphoma.
    Pharmacotherapy, 2020, Volume: 40, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Body Size; Central Nervous System Neoplasms; Female; Humans; Kidney; Lymphoma; Male; Medical Records; Methotrexate; Middle Aged; Obesity; Retrospective Studies

2020
Metabolome Analysis Reveals Excessive Glycolysis via PI3K/AKT/mTOR and RAS/MAPK Signaling in Methotrexate-Resistant Primary CNS Lymphoma-Derived Cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 06-01, Volume: 26, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lymphoma; Metabolome; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; ras Proteins; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Isolated Central Nervous System Relapse Following Treatment Reduction in Low-risk Acute Lymphoblastic Leukemia at the Children's Cancer Center of Lebanon.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Dexamethasone; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Infant; Lebanon; Male; Methotrexate; Neoplasm Recurrence, Local; Non-Randomized Controlled Trials as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate

2020
Outcomes of older patients with primary central nervous system lymphoma treated in routine clinical practice in the UK: methotrexate dose intensity correlates with response and survival.
    British journal of haematology, 2020, Volume: 190, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Consolidation Chemotherapy; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Methotrexate; Progression-Free Survival; Proportional Hazards Models; Remission Induction; Retrospective Studies; Rituximab; United Kingdom

2020
Methotrexate-associated lymphoproliferative disorders in the central nervous system and stomach: A case report.
    Medicine, 2020, Volume: 99, Issue:15

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Arthritis, Rheumatoid; Central Nervous System Neoplasms; Diagnosis, Differential; Endoscopy, Digestive System; Female; Gait Ataxia; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Rituximab; Stomach Neoplasms; Treatment Outcome

2020
GSEA-assisted gene signatures valid for combinations of prognostic markers in PCNSL.
    Scientific reports, 2020, 05-21, Volume: 10, Issue:1

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Prognosis; Tumor Cells, Cultured

2020
Primary central nervous system lymphoma: status and advances in diagnosis, molecular pathogenesis, and treatment.
    Chinese medical journal, 2020, Jun-20, Volume: 133, Issue:12

    Topics: Central Nervous System; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma, Non-Hodgkin; Methotrexate

2020
Consecutive single-institution case series of primary central nervous system lymphoma treated by R-MPV or high-dose methotrexate monotherapy.
    Japanese journal of clinical oncology, 2020, Sep-05, Volume: 50, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome

2020
Diagnostic delay and outcome in immunocompetent patients with primary central nervous system lymphoma in Spain: a multicentric study.
    Journal of neuro-oncology, 2020, Volume: 148, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Cytarabine; Delayed Diagnosis; Female; Follow-Up Studies; Humans; Immunocompetence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Young Adult

2020
Prediction and prevention of central nervous system relapse in patients with extranodal natural killer/T-cell lymphoma.
    Blood, 2020, 11-26, Volume: 136, Issue:22

    Topics: Aged; Central Nervous System Neoplasms; Female; Humans; Killer Cells, Natural; Lymphoma, Extranodal NK-T-Cell; Male; Methotrexate; Middle Aged; Models, Biological; Risk Factors

2020
Timing of high-dose methotrexate CNS prophylaxis in DLBCL: an analysis of toxicity and impact on R-CHOP delivery.
    Blood advances, 2020, 08-11, Volume: 4, Issue:15

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies; Rituximab; Vincristine

2020
Excellent outcomes in older patients with primary CNS lymphoma treated with R-MPV/cytarabine without whole brain radiotherapy or autologous stem cell transplantation therapy.
    Leukemia & lymphoma, 2021, Volume: 62, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Hematopoietic Stem Cell Transplantation; Humans; Methotrexate; Stem Cell Transplantation; Transplantation, Autologous

2021
Clinical outcomes of newly diagnosed primary CNS lymphoma treated with ibrutinib-based combination therapy: A real-world experience of off-label ibrutinib use.
    Cancer medicine, 2020, Volume: 9, Issue:22

    Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Disease Progression; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Off-Label Use; Piperidines; Progression-Free Survival; Protein Kinase Inhibitors; Retrospective Studies; Time Factors

2020
Influence of MTHFR C677T Polymorphism on High-Dose Methotrexate-Related Toxicity in Patients With Primary Central Nervous System Diffuse Large B-Cell Lymphoma.
    Clinical lymphoma, myeloma & leukemia, 2021, Volume: 21, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Homozygote; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies

2021
Real-time intracranial pressure monitoring during high-dose methotrexate treatment for primary central nervous system lymphoma.
    Cancer treatment and research communications, 2020, Volume: 25

    Topics: Adult; Central Nervous System Neoplasms; Female; Humans; Intracranial Pressure; Lymphoma, Non-Hodgkin; Methotrexate

2020
Gamma knife stereotactic radiosurgery as an effective tool in primary CNS lymphoma: Evaluation of stereotactic radiosurgery and methotrexate treatment in a prospective and observational clinical research study.
    Clinical neurology and neurosurgery, 2021, Volume: 201

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Radiosurgery; Treatment Outcome

2021
Diagnosis and treatment of primary central nervous system lymphoma with the primary lesion in the hypothalamus: a case report.
    BMC endocrine disorders, 2021, Jan-11, Volume: 21, Issue:1

    Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Combined Modality Therapy; Endocrine System Diseases; Hormone Replacement Therapy; Humans; Hypopituitarism; Hypothalamic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Treatment Outcome

2021
Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients.
    Scientific reports, 2021, 01-13, Volume: 11, Issue:1

    Topics: Aged; B7-H1 Antigen; Biomarkers, Tumor; Central Nervous System; Central Nervous System Neoplasms; Female; Humans; Immunoglobulins; Lymphoma; Macrophages; Male; Membrane Proteins; Methotrexate; Prognosis; Tumor Microenvironment

2021
Ineffectiveness of high-dose methotrexate for prevention of CNS relapse in diffuse large B-cell lymphoma.
    American journal of hematology, 2021, 07-01, Volume: 96, Issue:7

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult

2021
Efficacy and safety of prophylactic high-dose MTX in high-risk DLBCL: a treatment intent-based analysis.
    Blood advances, 2021, 04-27, Volume: 5, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies

2021
Treatment patterns and disease course of previously untreated Primary Central Nervous System Lymphoma: Feasibility of MTX-based regimens in clinical routine.
    European journal of haematology, 2021, Volume: 107, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Germany; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Practice Patterns, Physicians'; Prognosis; Recurrence; Retreatment; Survival Analysis; Treatment Outcome; Young Adult

2021
Delayed methotrexate elimination in a patient with primary central nervous system lymphoma: A case report.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:6

    Topics: Aged; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Levofloxacin; Lymphoma; Methotrexate

2021
Prophylactic high-dose methotrexate in diffuse large B cell lymphoma, authors' response.
    American journal of hematology, 2021, 09-01, Volume: 96, Issue:9

    Topics: Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate

2021
Interpretation of retrospective data evaluating high-dose methotrexate as central nervous system prophylaxis in diffuse large B-cell lymphoma; caution required.
    American journal of hematology, 2021, 09-01, Volume: 96, Issue:9

    Topics: Central Nervous System; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local; Retrospective Studies

2021
R-CHOP intensification with mid-cycle methotrexate and consolidating AraC/TT with BCNU/aHSCT in primary aggressive lymphoma with CNS involvement.
    Journal of cancer research and clinical oncology, 2022, Volume: 148, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Progression-Free Survival; Retrospective Studies; Rituximab; Vincristine

2022
Prophylaxis with intrathecal or high-dose methotrexate in diffuse large B-cell lymphoma and high risk of CNS relapse.
    Blood cancer journal, 2021, 06-16, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Retrospective Studies; Risk Factors; Rituximab; Vincristine

2021
Successful treatment of CNS involvement in a patient with widely disseminated PTLD through the addition of intrathecal methotrexate to standard therapy.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:11

    Topics: Central Nervous System Neoplasms; Child; Humans; Injections, Spinal; Lymphoproliferative Disorders; Methotrexate; Organ Transplantation

2021
Role of 23.4 Gy upfront whole-brain radiation therapy following high-dose methotrexate for primary central nervous system lymphoma: a comparative analysis of whole-brain radiation therapy versus no radiation therapy.
    Journal of neuro-oncology, 2021, Volume: 154, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Retrospective Studies; Rituximab

2021
Improved survival outcomes despite older age at diagnosis: an era-by-era analysis of patients with primary central nervous system lymphoma treated at a single referral centre in the United Kingdom.
    British journal of haematology, 2021, Volume: 195, Issue:4

    Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Hematopoietic Stem Cell Transplantation; Hospitals, University; Humans; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mortality; Progression-Free Survival; Proportional Hazards Models; Retrospective Studies; Transplantation, Autologous; Treatment Outcome; United Kingdom; Vincristine

2021
High-dose methotrexate is effective for prevention of isolated CNS relapse in diffuse large B cell lymphoma.
    Blood cancer journal, 2021, 08-12, Volume: 11, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies

2021
High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with primary central nervous system lymphoma in first complete remission.
    Cancer, 2017, Aug-15, Volume: 123, Issue:16

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Busulfan; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dacarbazine; Disease-Free Survival; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Mucositis; Remission Induction; Retrospective Studies; Rituximab; Stem Cell Transplantation; Temozolomide; Thiotepa; Transplantation Conditioning; Transplantation, Autologous

2017
Methotrexate-cytarabine-dexamethasone combination chemotherapy with or without rituximab in patients with primary central nervous system lymphoma.
    Oncotarget, 2017, Jul-25, Volume: 8, Issue:30

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Cytarabine; Dexamethasone; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Proportional Hazards Models; Remission Induction; Rituximab; Survival Analysis; Treatment Outcome; Young Adult

2017
The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma.
    Annals of hematology, 2017, Volume: 96, Issue:7

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Forkhead Transcription Factors; Hematopoietic Stem Cell Transplantation; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Prognosis; Proportional Hazards Models; Retrospective Studies; Transplantation, Autologous

2017
Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Aug-01, Volume: 35, Issue:22

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Cerebrospinal Fluid; Child; Clinical Trials as Topic; Cranial Irradiation; Dexamethasone; Disease-Free Survival; Erythrocyte Count; Female; Humans; Leucovorin; Leukocyte Count; Male; Methotrexate; Polyethylene Glycols; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Survival Rate

2017
Interim
    Annals of hematology, 2017, Volume: 96, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Positron-Emission Tomography; Registries; Retrospective Studies; Survival Rate

2017
Targeted therapy of CNS leukemia?
    Blood, 2017, 08-03, Volume: 130, Issue:5

    Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study.
    Anticancer research, 2017, Volume: 37, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult

2017
Whole brain radiation dose reduction for primary central nervous system lymphoma patients who achieved partial response after high-dose methotrexate based chemotherapy.
    Japanese journal of clinical oncology, 2017, 11-01, Volume: 47, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Radiation Dosage; Retrospective Studies

2017
Immunochemotherapy using rituximab (RTX) and high-dose methotrexate (HD-MTX): an evaluation of the addition of RTX to HD-MTX in recurrent primary central nervous system lymphoma (PCNSL).
    Japanese journal of clinical oncology, 2017, Oct-01, Volume: 47, Issue:10

    Topics: Aged; Central Nervous System Neoplasms; Humans; Immunotherapy; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Rituximab

2017
Prognostic factors for primary central nervous system lymphomas treated with high-dose methotrexate-based chemo-radiotherapy.
    Japanese journal of clinical oncology, 2017, Oct-01, Volume: 47, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Chemoradiotherapy; Disease-Free Survival; Female; Humans; Immunohistochemistry; Male; Methotrexate; Middle Aged; Prognosis; Young Adult

2017
Primary central nervous system lymphoma: Retrospective analysis of 34 cases in a single centre.
    The Journal of international medical research, 2018, Volume: 46, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Dexamethasone; Doxorubicin; Drug Administration Schedule; Drug Dosage Calculations; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Rituximab; Survival Analysis; Temozolomide; Vincristine

2018
Primary central nervous system lymphoma in an immunocompetent patient: an unusual case of prolonged response to steroids.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018, Volume: 39, Issue:5

    Topics: Central Nervous System Neoplasms; Gadolinium; Humans; Immunocompetence; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Steroids

2018
Efficacy and safety of HD-MTX based systemic chemotherapy regimens: retrospective study of induction therapy for primary central nervous system lymphoma in Chinese.
    Scientific reports, 2017, 12-06, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; China; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Nervous System Diseases; Progression-Free Survival; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult

2017
[Clinical Analysis of Combination Chemotherapy Using High Dose Methotrexate, Rituximab, and Vincristine with or without Procarbazine for Elderly Patients with Diffuse Large B-Cell Lymphoma of the Central Nervous System].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2017, Volume: 44, Issue:13

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Procarbazine; Rituximab; Treatment Outcome; Vincristine

2017
Clinical significance of polyglutamylation in primary central nervous system lymphoma.
    Acta neuropathologica communications, 2018, 02-23, Volume: 6, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome; Vitamin B Complex

2018
Leukocytoclastic Vasculitis and Desensitization to High-dose Methotrexate in Primary Central Nervous System Lymphoma.
    Clinical lymphoma, myeloma & leukemia, 2018, Volume: 18, Issue:5

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Desensitization, Immunologic; Dose-Response Relationship, Drug; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Premedication; Treatment Outcome; Vasculitis, Leukocytoclastic, Cutaneous

2018
Nivolumab maintenance after salvage autologous stem cell transplantation results in long-term remission in multiple relapsed primary CNS lymphoma.
    European journal of haematology, 2018, Volume: 101, Issue:1

    Topics: Adult; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Exome Sequencing; Female; Gene Expression; Hematopoietic Stem Cell Transplantation; Humans; Magnetic Resonance Imaging; Methotrexate; Neoplasm Recurrence, Local; Nivolumab; Programmed Cell Death 1 Receptor; Remission Induction; T-Lymphocytes; Transplantation, Autologous; Treatment Outcome

2018
Durable Complete Response of Primary CNS Lymphoma in an 80-Year-Old Patient with Retroviral Infection.
    Connecticut medicine, 2017, Volume: 81, Issue:4

    Topics: Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Central Nervous System Neoplasms; Humans; Lymphoma, AIDS-Related; Male; Methotrexate; Rituximab

2017
[Not Available].
    Bulletin de l'Academie nationale de medecine, 2015, Volume: 199, Issue:8-9

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Diagnosis, Differential; Dose-Response Relationship, Drug; Genetic Heterogeneity; Humans; Immunophenotyping; Lymphoma; Methotrexate

2015
Simultaneous determination of plasma methotrexate and 7-hydroxy methotrexate by UHPLC-MS/MS in patients receiving high-dose methotrexate therapy.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-05, Volume: 158

    Topics: Calibration; Central Nervous System Neoplasms; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Monitoring; Folic Acid Antagonists; Humans; Kidney; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate; Sensitivity and Specificity; Tandem Mass Spectrometry

2018
in vitro- and in vivo Evaluation of Methotrexate-Loaded Hydrogel Nanoparticles Intended to Treat Primary CNS Lymphoma via Intranasal Administration.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2018, Volume: 21, Issue:1

    Topics: Administration, Intranasal; Animals; Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; Drug Liberation; Hydrogels; Lymphoma; Male; Methotrexate; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Surface Properties; Tissue Distribution

2018
Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma.
    Oncology reports, 2019, Volume: 41, Issue:1

    Topics: Adult; Aged; Brain; Central Nervous System Neoplasms; Disease Progression; Eye; Eye Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Progression-Free Survival; Prospective Studies; Risk; Young Adult

2019
High-dose intravenous methotrexate with high-flux, extended-hours haemodialysis in treatment of primary central nervous system, post-transplant lymphoproliferative disorder and end-stage kidney disease: A case report.
    Nephrology (Carlton, Vic.), 2018, Volume: 23, Issue:11

    Topics: Adult; Central Nervous System Neoplasms; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lymphoma; Male; Methotrexate; Renal Dialysis

2018
Rhabdomyolysis during myelosuppression in a patient with central nervous system leukemia: A case report.
    Medicine, 2018, Volume: 97, Issue:45

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Fatal Outcome; Humans; Leukemia, T-Cell; Male; Methotrexate; Rhabdomyolysis; Vincristine; Young Adult

2018
Altered methotrexate clearance in the treatment of CNS lymphoma with concurrent use of nitrofurantoin for a urinary tract infection.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:7

    Topics: Aged; Central Nervous System Neoplasms; Drug Interactions; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Nitrofurantoin; Urinary Tract Infections

2019
[Primary central nervous system lymphoma].
    La Revue du praticien, 2016, Volume: 66, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; France; Humans; Lymphoma; Methotrexate; Neoplasm Recurrence, Local

2016
A Rare Case of Primary Central Nervous System Lymphoma in an Adolescent Female Treated with High-Dose Methotrexate and Rituximab-Based Chemoimmunotherapy and Consolidation Whole Brain Radiotherapy.
    Pediatric neurosurgery, 2019, Volume: 54, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Female; Humans; Immunotherapy; Lymphoma; Methotrexate; Rituximab

2019
Addition of high-dose methotrexate to standard treatment for patients with high-risk diffuse large B-cell lymphoma contributes to improved freedom from progression and survival but does not prevent central nervous system relapse.
    Leukemia & lymphoma, 2019, Volume: 60, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Disease Progression; Doxorubicin; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Proportional Hazards Models; Risk Factors; Rituximab; Treatment Outcome; Vincristine; Young Adult

2019
Long-Term Evaluation of Combination Treatment of Single Agent HD-MTX Chemotherapy up to Three Cycles and Moderate Dose Whole Brain Irradiation for Primary CNS Lymphoma.
    Journal of chemotherapy (Florence, Italy), 2019, Volume: 31, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Retrospective Studies

2019
Primary CNS Lymphoma in India: A 17-Year Experience From the All India Institute of Medical Sciences.
    Journal of global oncology, 2019, Volume: 5

    Topics: Adolescent; Adult; Aged; Central Nervous System Neoplasms; Chemoradiotherapy; Female; Humans; India; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis; Treatment Outcome; Young Adult

2019
High-dose Methotrexate plus temozolomide with or without rituximab in patients with untreated primary central nervous system lymphoma: A retrospective study from China.
    Cancer medicine, 2019, Volume: 8, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Induction Chemotherapy; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Multivariate Analysis; Retrospective Studies; Rituximab; Survival Analysis; Temozolomide; Treatment Outcome

2019
Primary central nervous system plasmablastic lymphoma in an HIV-positive patient.
    BMJ case reports, 2019, Mar-14, Volume: 12, Issue:3

    Topics: Adult; Antimetabolites, Antineoplastic; Antiretroviral Therapy, Highly Active; Central Nervous System Neoplasms; Epstein-Barr Virus Infections; Herpesvirus 4, Human; HIV; HIV Infections; Humans; Male; Methotrexate; Plasmablastic Lymphoma; Rare Diseases; Sarcoma, Kaposi; Treatment Outcome

2019
Intrathecal dose intensification by CNS status at diagnosis in the treatment of children with acute lymphoblastic leukemia.
    Hematology (Amsterdam, Netherlands), 2019, Volume: 24, Issue:1

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate

2019
Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells.
    International journal of clinical oncology, 2019, Volume: 24, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Cell Line, Tumor; Central Nervous System Neoplasms; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Molecular Targeted Therapy; Peptide Synthases; Thymidylate Synthase

2019
Therapeutic Outcomes and Toxicity of High-Dose Methotrexate-Based Chemotherapy for Elderly Patients with Primary Central Nervous System Lymphoma: A Report on Six Cases.
    Acta haematologica, 2019, Volume: 142, Issue:3

    Topics: Aged, 80 and over; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate

2019
Systemic HD-MTX for CNS prophylaxis in high-risk DLBCL patients: a prospectively collected, single-center cohort analysis.
    International journal of hematology, 2019, Volume: 110, Issue:1

    Topics: Adult; Aged; Central Nervous System Neoplasms; Cohort Studies; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Premedication; Prospective Studies; Recurrence; Risk Assessment; Survival Analysis; Treatment Outcome

2019
It's not all about the CNS. High dose methotrexate in DLBCL.
    Leukemia & lymphoma, 2019, Volume: 60, Issue:8

    Topics: Central Nervous System Neoplasms; Freedom; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasm Recurrence, Local

2019
[A case of secondary central nervous system lymphoma presenting marked hypoglycorrhachia].
    Rinsho shinkeigaku = Clinical neurology, 2019, Jun-22, Volume: 59, Issue:6

    Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Diagnostic Imaging; Doxorubicin; Glucose; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Oculomotor Nerve Diseases; Prednisolone; Prednisone; Rituximab; Treatment Outcome; Vincristine

2019
Stand-alone intrathecal central nervous system (CNS) prophylaxis provide unclear benefit in reducing CNS relapse risk in elderly DLBCL patients treated with R-CHOP and is associated increased infection-related toxicity.
    British journal of haematology, 2019, Volume: 187, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Prednisone; Rituximab; Survival Rate; Vincristine

2019
Temozolomide as a Single Agent Maintenance Therapy in Elderly Patients With Primary CNS Lymphoma.
    Clinical lymphoma, myeloma & leukemia, 2019, Volume: 19, Issue:10

    Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Drug Therapy, Combination; Female; Humans; Lymphoma, Non-Hodgkin; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Neutropenia; Procarbazine; Progression-Free Survival; Rituximab; Temozolomide; Vincristine

2019
[Our experience with the treatment of primary lymphomas of the central nervous system].
    Vnitrni lekarstvi, 2012, Volume: 58, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Rituximab; Survival Rate

2012
Primary central nervous system lymphoma.
    Current treatment options in oncology, 2013, Volume: 14, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Humans; Methotrexate; Middle Aged

2013
Central nervous system prophylaxis in patients with aggressive diffuse large B cell lymphoma: an analysis of 3,258 patients in a single center.
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cancer Care Facilities; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Follow-Up Studies; Humans; Hydrocortisone; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged

2013
Rituximab is associated with improved survival for aggressive B cell CNS lymphoma.
    Neuro-oncology, 2013, Volume: 15, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cytarabine; Female; Follow-Up Studies; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Prognosis; Radiotherapy Dosage; Retrospective Studies; Rituximab; Survival Rate; Young Adult

2013
Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma.
    Neurology, 2013, Jul-02, Volume: 81, Issue:1

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Cognition; Humans; Lymphoma; Methotrexate; Neuroimaging; Neuropsychological Tests; Prospective Studies; Quality of Life

2013
Is there a role for radiotherapy in the primary management of primary central nervous system lymphoma? A single-centre case series.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2013, Volume: 25, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; Chemoradiotherapy; Female; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Vincristine

2013
Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving low-dose methotrexate treatment.
    British journal of neurosurgery, 2013, Volume: 27, Issue:6

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Central Nervous System Neoplasms; Female; Humans; Immunohistochemistry; Interleukin-2 Receptor alpha Subunit; Lymphoma; Lymphoproliferative Disorders; Methotrexate; Middle Aged; Treatment Outcome

2013
Treatment outcome of relapsed/refractory primary central nervous system diffuse large B-cell lymphoma: a single-center experience of autologous stem cell transplantation.
    International journal of hematology, 2013, Volume: 98, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Etoposide; Female; Humans; Ifosfamide; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Salvage Therapy; Stem Cell Transplantation; Transplantation, Autologous; Treatment Outcome; Young Adult

2013
Recent advances in treatment of primary central nervous system lymphoma.
    Current treatment options in oncology, 2013, Volume: 14, Issue:4

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Prognosis; Quality of Life; Radiotherapy, Adjuvant; Salvage Therapy; Stem Cell Transplantation

2013
High-dose methotrexate, high-dose cytarabine and temozolomide for the treatment of primary central nervous system lymphoma (PCNSL).
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:4

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Disease-Free Survival; Female; Humans; Male; Methotrexate; Middle Aged; Survival Rate; Temozolomide; Young Adult

2013
Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma.
    Cancer, 2011, Jun-01, Volume: 117, Issue:11

    Topics: Central Nervous System Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate

2011
The risk of CNS involvement in aggressive lymphomas in the rituximab era.
    Expert review of hematology, 2013, Volume: 6, Issue:6

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Recurrence; Risk Factors; Rituximab; Stem Cell Transplantation; Transplantation, Autologous

2013
Primary CNS lymphoma treated with radiotherapy in Japan: a survey of patients treated in 2005-2009 and a comparison with those treated in 1985-2004.
    International journal of clinical oncology, 2014, Volume: 19, Issue:5

    Topics: Adult; Aged; Central Nervous System; Central Nervous System Neoplasms; Female; Humans; Japan; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Surveys and Questionnaires; Survival Rate

2014
Single-agent rituximab for primary CNS lymphoma during pregnancy as a bridge to definitive management.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Mar-01, Volume: 32, Issue:7

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain; Carmustine; Central Nervous System Neoplasms; Cesarean Section; Cytarabine; Dexamethasone; Drug Administration Schedule; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Melphalan; Methotrexate; Podophyllotoxin; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Rituximab; Transplantation, Autologous; Treatment Outcome

2014
Successful treatment of AIDS-associated, primary CNS lymphoma with rituximab- and methotrexate-based chemotherapy and autologous stem cell transplantation.
    Infection, 2014, Volume: 42, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Central Nervous System Neoplasms; Epstein-Barr Virus Infections; Hematopoietic Stem Cell Transplantation; Herpesvirus 4, Human; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Rituximab; Transplantation, Autologous; Treatment Outcome

2014
Methotrexate re-challenge for recurrent primary central nervous system lymphoma.
    Journal of neuro-oncology, 2014, Volume: 117, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retreatment; Retrospective Studies; Salvage Therapy; Treatment Outcome

2014
Non-deep-seated primary CNS lymphoma: therapeutic responses and a molecular signature.
    Journal of neuro-oncology, 2014, Volume: 117, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Central Nervous System Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Oligonucleotide Array Sequence Analysis; Prognosis; Proportional Hazards Models; Retrospective Studies; Transcriptome; Treatment Outcome

2014
Salvage therapy with bendamustine for methotrexate refractory recurrent primary CNS lymphoma: a retrospective case series.
    Journal of neuro-oncology, 2014, Volume: 118, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Central Nervous System Neoplasms; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Nitrogen Mustard Compounds; Retrospective Studies; Salvage Therapy; Treatment Outcome

2014
Primary B-cell CNS lymphoma clinicopathologic and treatment outcomes in 89 patients from a single tertiary care center.
    International journal of hematology, 2014, Volume: 99, Issue:4

    Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Radiotherapy; Retrospective Studies; Risk Factors; Rituximab; Tertiary Care Centers; Treatment Outcome; Young Adult

2014
Clinical outcomes of patients with newly diagnosed primary central nervous system lymphoma are comparable on treatment with high-dose methotrexate plus temozolomide and with high-dose methotrexate plus cytarabine: a single-institution experience.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neutropenia; Remission Induction; Temozolomide; Thrombocytopenia; Treatment Outcome; Young Adult

2014
Combined treatment of rituximab, idarubicin, dexamethasone, cytarabine, methotrexate with radiotherapy for primary central nervous system lymphoma.
    Journal of cellular and molecular medicine, 2014, Volume: 18, Issue:6

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cytarabine; Dexamethasone; Female; Humans; Idarubicin; Lymphoma; Male; Methotrexate; Middle Aged; Multimodal Imaging; Neoplasm Staging; Prognosis; Rituximab

2014
MATILDE chemotherapy regimen for primary CNS lymphoma: results at a median follow-up of 12 years.
    Neurology, 2014, Apr-15, Volume: 82, Issue:15

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Humans; Idarubicin; Lymphoma; Male; Methotrexate; Remission Induction; Thiotepa; Treatment Outcome

2014
Prognostic impact of completion of initial high-dose methotrexate therapy on primary central nervous system lymphoma: a single institution experience.
    International journal of clinical oncology, 2015, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Retrospective Studies; Treatment Outcome

2015
Therapy of HIV-associated lymphoma-recommendations of the oncology working group of the German Study Group of Physicians in Private Practice Treating HIV-Infected Patients (DAGNÄ), in cooperation with the German AIDS Society (DAIG).
    Annals of hematology, 2014, Volume: 93, Issue:6

    Topics: Anti-HIV Agents; Antibiotic Prophylaxis; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Antiretroviral Therapy, Highly Active; Castleman Disease; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Interactions; Etoposide; Hematopoietic Stem Cell Transplantation; HIV Infections; Humans; Lymphoma, AIDS-Related; Methotrexate; Neoplasm Staging; Prednisolone; Prednisone; Radiotherapy, Adjuvant; Risk Assessment; Rituximab; Vincristine

2014
Outcome of patients with primary central nervous system lymphoma treated outside clinical trials.
    The Netherlands journal of medicine, 2014, Volume: 72, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Rate; Treatment Outcome

2014
What is the optimal dose of high-dose methotrexate in the initial treatment of primary central nervous system lymphoma?
    Leukemia & lymphoma, 2015, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Kidney Diseases; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Treatment Outcome; Young Adult

2015
Intrathecal methotrexate prophylaxis and central nervous system relapse in patients with diffuse large B-cell lymphoma following rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone.
    Leukemia & lymphoma, 2015, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Injections, Spinal; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prednisone; Remission Induction; Retrospective Studies; Rituximab; Treatment Outcome; Vincristine; Young Adult

2015
High-dose methotrexate with or without rituximab in newly diagnosed primary CNS lymphoma.
    Neurology, 2014, Jul-15, Volume: 83, Issue:3

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Central Nervous System Neoplasms; Disease-Free Survival; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome

2014
Upfront autologous stem-cell transplantation with melphalan, cyclophosphamide, etoposide, and dexamethasone (LEED) in patients with newly diagnosed primary central nervous system lymphoma.
    International journal of hematology, 2014, Volume: 100, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Etoposide; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Melphalan; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Stem Cell Transplantation; Survival Analysis; Transplantation, Autologous; Treatment Outcome

2014
Fotemustine, teniposide and dexamethasone in treating patients with CNS lymphoma.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Organophosphorus Compounds; Radiotherapy, Adjuvant; Teniposide; Young Adult

2014
Therapeutic and survival outcomes following treatment of primary central nervous system lymphoma: a 12-year case study.
    Journal of neurosurgical sciences, 2014, Volume: 58, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult

2014
Analysis of radiotherapy in 1054 patients with primary central nervous system lymphoma treated from 1985 to 2009.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2014, Volume: 26, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Child; Child, Preschool; Cranial Irradiation; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Staging; Prognosis; Radiotherapy Dosage; Survival Rate; Time Factors

2014
A multicentre retrospective comparison of central nervous system prophylaxis strategies among patients with high-risk diffuse large B-cell lymphoma.
    British journal of cancer, 2014, Sep-09, Volume: 111, Issue:6

    Topics: Acute Kidney Injury; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Ifosfamide; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Retrospective Studies; Risk Assessment; Rituximab; Survival Rate; Vincristine; Young Adult

2014
Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:1

    Topics: Antimetabolites, Antineoplastic; Ascitic Fluid; Central Nervous System Neoplasms; Child, Preschool; Cohort Studies; Combined Modality Therapy; Down-Regulation; Drainage; Female; Humans; Infant; Infant, Newborn; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Neuroprotective Agents; Pericardial Effusion; Pleural Effusion, Malignant; Postoperative Complications; Retrospective Studies; Subdural Effusion

2015
A simple but very important missing point about intrathecal chemotherapy.
    Hematological oncology, 2016, Volume: 34, Issue:2

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Reduced neurotoxicity with combined treatment of high-dose methotrexate, cyclophosphamide, doxorubicin, vincristine and prednisolone (M-CHOP) and deferred radiotherapy for primary central nervous system lymphoma.
    Clinical neurology and neurosurgery, 2014, Volume: 127

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Lymphoma; Male; Methotrexate; Middle Aged; Neuropsychological Tests; Prednisolone; Survival Analysis; Treatment Outcome; Vincristine

2014
[Clinical efficacy of idarubicin combined with methotrexate for treatment of patients with central nervous system diffuse large B cell lymphoma].
    Zhongguo shi yan xue ye xue za zhi, 2014, Volume: 22, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Humans; Idarubicin; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Remission Induction; Treatment Outcome

2014
Delayed methotrexate excretion in infants and young children with central nervous system tumors and postoperative fluid collections.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:4

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Leucovorin; Male; Methotrexate; Neuroprotective Agents; Postoperative Complications; Subdural Effusion

2015
High-dose methotrexate with or without rituximab in newly diagnosed primary CNS lymphoma.
    Neurology, 2015, Feb-17, Volume: 84, Issue:7

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Humans; Immunosuppressive Agents; Lymphoma; Male; Methotrexate

2015
Response to: comment on "Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections".
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:4

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Leucovorin; Male; Methotrexate; Neuroprotective Agents; Postoperative Complications; Subdural Effusion

2015
Primary CNS lymphoma: a landmark trial and the next steps.
    Neurology, 2015, Mar-24, Volume: 84, Issue:12

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma; Male; Methotrexate; Treatment Outcome

2015
Primary central nervous system lymphoma in a rheumatoid arthritis patient treated with methotrexate: a case report.
    BMC research notes, 2015, Mar-19, Volume: 8

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Tomography, X-Ray Computed

2015
Stereotactic radiosurgery in combination with up-front high-dose methotrexate as a first-line treatment for newly diagnosed primary central nervous system lymphoma.
    Journal of neuro-oncology, 2015, Volume: 123, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Radiosurgery; Radiotherapy Dosage; Retrospective Studies; Salvage Therapy; Survival Rate

2015
Neuro-oncology: Primary CNS lymphoma treatment--the devil is in the details.
    Nature reviews. Neurology, 2015, Volume: 11, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cranial Irradiation; Humans; Lymphoma; Male; Methotrexate; Treatment Outcome

2015
Treatment of young children with CNS-positive acute lymphoblastic leukemia without cranial radiotherapy.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child, Preschool; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate

2015
A Demyelinating Disease; What Lies Beneath?
    Indian journal of pediatrics, 2016, Volume: 83, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Demyelinating Diseases; Diagnosis, Differential; Doxorubicin; Encephalomyelitis, Acute Disseminated; Etoposide; Humans; Hydrocortisone; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Male; Methotrexate; Prednisone; Vincristine

2016
Treatment of Primary Central Nervous System Lymphoma with High-dose Methotrexate and Radiotherapy in HIV-negative Patients.
    Archives of Iranian medicine, 2015, Volume: 18, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Central Nervous System Neoplasms; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Retrospective Studies; Vincristine

2015
Rituximab with high-dose methotrexate in primary central nervous system lymphoma.
    American journal of hematology, 2015, Volume: 90, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Rituximab; Young Adult

2015
Late relapses in primary CNS lymphoma after complete remissions with high-dose methotrexate monotherapy.
    CNS oncology, 2015, Volume: 4, Issue:6

    Topics: Adult; Aged; Central Nervous System Neoplasms; Disease-Free Survival; Humans; Kaplan-Meier Estimate; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Treatment Outcome

2015
Impact of oncogene rearrangement patterns on outcomes in patients with double-hit non-Hodgkin lymphoma.
    Cancer, 2016, Feb-15, Volume: 122, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Burkitt Lymphoma; Central Nervous System Neoplasms; Cohort Studies; Cyclophosphamide; Cytarabine; Databases, Factual; Dexamethasone; DNA-Binding Proteins; Doxorubicin; Etoposide; Female; Gene Rearrangement; Genes, bcl-2; Genes, myc; Germinal Center; Humans; Ifosfamide; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Proto-Oncogene Proteins c-bcl-6; Rituximab; Survival Rate; Vincristine

2016
Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy.
    British journal of haematology, 2016, Volume: 172, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease Progression; Disease-Free Survival; Female; Humans; Idarubicin; Infusions, Intravenous; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Treatment Outcome

2016
High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system.
    Leukemia & lymphoma, 2016, Volume: 57, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Fatal Outcome; Female; Histiocytic Sarcoma; Humans; Methotrexate; Middle Aged; Remission Induction

2016
A new prognostic model using absolute lymphocyte count in patients with primary central nervous system lymphoma.
    European journal of cancer (Oxford, England : 1990), 2016, Volume: 57

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Female; Humans; Kaplan-Meier Estimate; Lymphocyte Count; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Methotrexate; Middle Aged; Prognosis; Stem Cell Transplantation; Thiotepa; Transplantation, Autologous; Vincristine

2016
Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.
    Ocular immunology and inflammation, 2017, Volume: 25, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Eye Neoplasms; Female; Humans; Immunosuppressive Agents; Injections, Spinal; Intraocular Lymphoma; Intravitreal Injections; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Radiotherapy; Retrospective Studies; Tertiary Care Centers; Treatment Outcome; Visual Acuity; Vitrectomy

2017
The role of upfront autologous stem cell transplantation in high-risk younger patients with primary central nervous system lymphoma.
    British journal of haematology, 2016, Volume: 174, Issue:3

    Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Remission Induction; Republic of Korea; Retrospective Studies; Risk Assessment; Transplantation, Autologous; Young Adult

2016
Central nervous system involvement in T-cell lymphoma: A single center experience.
    Acta oncologica (Stockholm, Sweden), 2016, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Female; Glioblastoma; Humans; Incidence; Injections, Spinal; Lactate Dehydrogenases; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Male; Methotrexate; Middle Aged; Neoplasm Staging; Practice Guidelines as Topic; Prognosis; Recurrence; Retrospective Studies; Risk Factors; Young Adult

2016
Defining optimal initial therapy for primary CNS lymphoma.
    The Lancet. Haematology, 2016, Volume: 3, Issue:5

    Topics: Central Nervous System Neoplasms; Cytarabine; Humans; Methotrexate; Rituximab; Thiotepa

2016
Value of pretherapeutic DWI in evaluating prognosis and therapeutic effect in immunocompetent patients with primary central nervous system lymphoma given high-dose methotrexate-based chemotherapy: ADC-based assessment.
    Clinical radiology, 2016, Volume: 71, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; Diffusion Magnetic Resonance Imaging; Disease-Free Survival; Female; Humans; Immunocompromised Host; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Reproducibility of Results; Retrospective Studies; ROC Curve

2016
High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma.
    Cancer science, 2016, Volume: 107, Issue:10

    Topics: Aged; Antimetabolites, Antineoplastic; Biomarkers; Central Nervous System Neoplasms; Cytokines; Female; Humans; Immunophenotyping; Intraocular Lymphoma; Intravitreal Injections; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome

2016
Dose-Adjusted EPOCH-R and Mid-Cycle High Dose Methotrexate for Patients with Systemic Lymphoma and secondary CNS Involvement.
    British journal of haematology, 2017, Volume: 179, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Lymphoma; Methotrexate; Prednisone; Rituximab; Treatment Outcome; Vincristine

2017
Long-term survival in AIDS-related primary central nervous system lymphoma.
    Neuro-oncology, 2017, Volume: 19, Issue:1

    Topics: Adult; Aged; Anti-Retroviral Agents; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Lymphoma, AIDS-Related; Male; Methotrexate; Middle Aged; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate

2017
Methotrexate elimination and toxicity: MTHFR 677C>T polymorphism in patients with primary CNS lymphoma treated with high-dose methotrexate.
    Hematological oncology, 2017, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Young Adult

2017
Intravitreal injections of methotrexate in treatment of primary central nervous system lymphoma with intraocular involvement.
    The Kaohsiung journal of medical sciences, 2016, Volume: 32, Issue:12

    Topics: Aged; Brain; Central Nervous System Neoplasms; Eye; Fatal Outcome; Humans; Intravitreal Injections; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate

2016
Utility of post-therapy brain surveillance imaging in the detection of primary central nervous system lymphoma relapse.
    European journal of cancer (Oxford, England : 1990), 2017, Volume: 72

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Rituximab

2017
[Clinicopathological Features of Primary Central Nervous System Lymphoma and Their Influence on Prognosis of Desease].
    Zhongguo shi yan xue ye xue za zhi, 2016, Volume: 24, Issue:6

    Topics: Aged; Brain Neoplasms; Central Nervous System Neoplasms; Cytarabine; Humans; Lymphoma, B-Cell; Lymphoma, T-Cell, Peripheral; Methotrexate; Prognosis; Rituximab

2016
High-Dose Methotrexate and Cytarabine-Based Multi-Agent Chemotherapy (Modified Bonn Protocol) for Systemic Lymphoma with CNS Involvement.
    Acta haematologica, 2017, Volume: 137, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Rate

2017
Primary central nervous system lymphoma: the role of consolidation treatment after a complete response to high-dose methotrexate-based chemotherapy.
    Cancer, 2008, Sep-01, Volume: 113, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Survival Analysis

2008
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate.
    World journal of pediatrics : WJP, 2008, Volume: 4, Issue:2

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Blood Cell Count; Central Nervous System Neoplasms; Chemoprevention; Child; Clinical Protocols; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Imatinib Mesylate; Injections, Spinal; Methotrexate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction

2008
Systemic high-dose methotrexate plus ifosfamide is highly effective for central nervous system (CNS) involvement of lymphoma.
    Annals of hematology, 2009, Volume: 88, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome

2009
High-dose methotrexate for elderly patients with primary CNS lymphoma.
    Neuro-oncology, 2009, Volume: 11, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Prognosis; Survival Rate; Treatment Outcome

2009
Primary meningeal CNS lymphoma treated with intra-arterial chemotherapy and blood-brain barrier disruption.
    Journal of neuro-oncology, 2008, Volume: 90, Issue:3

    Topics: Antineoplastic Agents; Blood-Brain Barrier; Central Nervous System Neoplasms; Enzyme Inhibitors; Etoposide; Female; Humans; Injections, Intra-Arterial; Injections, Intravenous; Lymphoma, Large-Cell, Immunoblastic; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Organophosphorus Compounds

2008
Mobilization of hemopoietic stem cells with high-dose methotrexate plus granulocyte-colony-stimulating factor in patients with primary central nervous system lymphoma.
    Transfusion, 2008, Volume: 48, Issue:12

    Topics: Adult; Aged; Central Nervous System Neoplasms; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Humans; Lymphoma; Male; Methotrexate; Middle Aged

2008
Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma.
    Neuro-oncology, 2009, Volume: 11, Issue:1

    Topics: Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; Cystathionine beta-Synthase; Female; Humans; Hydroxymethyl and Formyl Transferases; Lymphoma; Male; Methionine; Methionine Sulfoxide Reductases; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Microfilament Proteins; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Oxidoreductases; Polymorphism, Genetic; Prospective Studies; Tetrahydrofolate Dehydrogenase; Transcobalamins; Transcription Factors; TRPM Cation Channels

2009
[Effects of infusion duration of high-dose methotrexate on cerebrospinal fluid drug levels in lymphoma patients].
    Ai zheng = Aizheng = Chinese journal of cancer, 2008, Volume: 27, Issue:10

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mucositis; Retrospective Studies; Young Adult

2008
Practice of central nervous system prophylaxis and treatment in acute leukemias in Spain. Prospective registry study.
    Medicina clinica, 2008, Oct-04, Volume: 131, Issue:11

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Myeloid, Acute; Liposomes; Longitudinal Studies; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Registries; Spain

2008
Epstein Barr virus-associated primary CNS lymphomas in elderly patients on immunosuppressive medications.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:11

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; CD3 Complex; Central Nervous System Neoplasms; Epstein-Barr Virus Infections; Female; Humans; Immune Tolerance; Immunoglobulin Heavy Chains; Immunosuppressive Agents; Lymphoma; Male; Methotrexate; Rituximab; Tomography Scanners, X-Ray Computed

2008
Successful salvage chemotherapy for isolated central nervous system (CNS) relapse in Burkitt lymphoma: monocentric experience of 3 pediatric patients.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Neoplasm Recurrence, Local; Remission Induction; Salvage Therapy; Treatment Outcome

2008
Efficacy and MRI of rituximab and methotrexate treatment in a nude rat model of CNS lymphoma.
    Neuro-oncology, 2009, Volume: 11, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Cell Line, Tumor; Central Nervous System Neoplasms; Female; Humans; Image Enhancement; Lymphoma, B-Cell; Magnetic Resonance Imaging; Methotrexate; Rats; Rats, Nude; Rituximab; Treatment Outcome; Xenograft Model Antitumor Assays

2009
Primary central nervous system lymphoma: an unusual presentation.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008, Volume: 98, Issue:11

    Topics: Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Disease Progression; Fatal Outcome; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate

2008
Management of patients with primary central nervous system lymphoma treated with high-dose methotrexate.
    Clinical journal of oncology nursing, 2009, Volume: 13, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; DNA-Binding Proteins; Humans; Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Proto-Oncogene Proteins c-bcl-6

2009
Blood-brain barrier disruption and intra-arterial methotrexate-based therapy for newly diagnosed primary CNS lymphoma: a multi-institutional experience.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jul-20, Volume: 27, Issue:21

    Topics: Antimetabolites, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Central Nervous System Neoplasms; Disease-Free Survival; Drug Delivery Systems; Humans; Infusions, Intra-Arterial; Lymphoma, Non-Hodgkin; Methotrexate; Osmosis; Prognosis; Treatment Outcome

2009
A retrospective study to compare two methotrexate-based regimens for primary central nervous system lymphoma.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Cohort Studies; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies

2009
[Lymphoma of the pituitary stalk].
    La Revue de medecine interne, 2010, Volume: 31, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Biopsy; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Pituitary Neoplasms; Spinal Puncture; Survival Analysis; Tomography, X-Ray Computed

2010
Progress in primary CNS lymphoma.
    Lancet (London, England), 2009, Oct-31, Volume: 374, Issue:9700

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials, Phase II as Topic; Cytarabine; Humans; Lymphoma; Methotrexate; Randomized Controlled Trials as Topic

2009
CXCL13 and CXCL12 in central nervous system lymphoma patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Oct-01, Volume: 15, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Case-Control Studies; Central Nervous System Neoplasms; Chemokine CXCL12; Chemokine CXCL13; Disease Progression; Female; Humans; Ifosfamide; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis

2009
[Therapeutic management of central nervous system lymphomas in a single hematological institute].
    Orvosi hetilap, 2009, Oct-18, Volume: 150, Issue:42

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease Progression; Doxorubicin; Drug Administration Schedule; Epidural Space; Female; Humans; Hungary; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prednisone; Radiotherapy Dosage; Radiotherapy, Adjuvant; Retrospective Studies; Rituximab; Salvage Therapy; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome; Vincristine

2009
Diffuse large B-cell lymphoma of the central nervous system in mycophenolate mofetil-treated patients with systemic lupus erythematosus.
    Lupus, 2010, Volume: 19, Issue:3

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimetabolites, Antineoplastic; Antineoplastic Agents; Central Nervous System Neoplasms; Epstein-Barr Virus Infections; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Mycophenolic Acid; Rituximab

2010
Central nervous system T-cell lymphoma in acquired immunodeficiency syndrome.
    British journal of haematology, 2010, Volume: 148, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Antiretroviral Therapy, Highly Active; Brain; Central Nervous System Neoplasms; Humans; Lamivudine; Lymphoma, T-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Pyrrolidinones; Raltegravir Potassium; Stavudine; Treatment Outcome

2010
Central nervous system involvement at the time of presentation in acute promyelocytic leukemia.
    Pediatric blood & cancer, 2010, Volume: 54, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Female; Humans; Leukemia, Promyelocytic, Acute; Leukemic Infiltration; Mercaptopurine; Methotrexate; Oncogene Proteins, Fusion; Radiotherapy; Sarcoma, Myeloid; Tretinoin

2010
Prognostic value of immunohistochemical profile and response to high-dose methotrexate therapy in primary CNS lymphoma.
    Journal of neuro-oncology, 2010, Volume: 98, Issue:3

    Topics: Adult; Aged; Antigens, CD; Central Nervous System Neoplasms; Disease-Free Survival; DNA-Binding Proteins; Female; Follow-Up Studies; Humans; Immunohistochemistry; Immunosuppressive Agents; Interferon Regulatory Factors; Lymphoma; Male; Methotrexate; Middle Aged; Proto-Oncogene Proteins c-bcl-6; Survival Analysis; Time Factors

2010
Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.
    Journal of neuro-oncology, 2010, Volume: 98, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Cohort Studies; Female; Humans; Immunosuppressive Agents; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis; Young Adult

2010
Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy.
    Journal of neuro-oncology, 2010, Volume: 99, Issue:1

    Topics: Adult; Aged; B-Lymphocytes; CD79 Antigens; Cell Differentiation; Central Nervous System Neoplasms; Disease-Free Survival; DNA-Binding Proteins; Female; Humans; Immunosuppressive Agents; Interferon Regulatory Factors; Lymphoma; Male; Methotrexate; Middle Aged; Neprilysin; Proto-Oncogene Proteins c-bcl-6; Retrospective Studies; Syndecan-1

2010
Treatment-induced leukoencephalopathy in primary CNS lymphoma presenting as lower body parkinsonism.
    Journal of neuro-oncology, 2010, Volume: 100, Issue:2

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Cranial Irradiation; Female; Hematopoietic Stem Cell Transplantation; Humans; Leukoencephalopathies; Lymphoma; Methotrexate; Middle Aged; Parkinsonian Disorders

2010
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement.
    International journal of hematology, 2010, Volume: 92, Issue:1

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Drug Administration Routes; Eye Neoplasms; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neoplasm Invasiveness; Treatment Outcome

2010
Hematology. Individualized methotrexate dosing in primary CNS lymphoma.
    Nature reviews. Clinical oncology, 2010, Volume: 7, Issue:6

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Hematologic Tests; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Treatment Outcome

2010
Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma.
    Cancer, 2010, Sep-15, Volume: 116, Issue:18

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Recurrence; Risk; Rituximab; Vincristine

2010
[High-dose methotrexate followed by whole-brain irradiation for primary central nervous system lymphoma patients--a retrospective study in a single institute].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:7

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Central Nervous System Neoplasms; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Rate

2010
Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis.
    Acta oncologica (Stockholm, Sweden), 2011, Volume: 50, Issue:1

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Central Nervous System Neoplasms; Drug Administration Schedule; Female; Fever; Fungemia; Humans; Immunocompromised Host; Immunosuppressive Agents; Lupus Nephritis; Lymphoma; Methotrexate; Mycophenolic Acid; Neurotoxicity Syndromes; Neutropenia; Rituximab; Treatment Outcome; Young Adult

2011
Flows and flaws in primary central nervous system lymphoma.
    Nature reviews. Clinical oncology, 2010, Volume: 7, Issue:8

    Topics: Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agents; Central Nervous System Neoplasms; Cytarabine; Decision Making; Drug Therapy, Combination; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Treatment Outcome

2010
Influence of methotrexate exposure on outcome in patients treated with MBVP chemotherapy for primary central nervous system lymphoma.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Statistics as Topic; Time Factors; Treatment Outcome

2010
Primary central nervous system lymphoma in the elderly: a multicentre retrospective analysis.
    British journal of haematology, 2010, Volume: 151, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Central Nervous System Neoplasms; Combined Modality Therapy; Epidemiologic Methods; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Prognosis; Treatment Outcome

2010
Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients.
    Pediatric blood & cancer, 2010, Dec-01, Volume: 55, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Infant; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Male; Methotrexate; Treatment Outcome

2010
Improved survival with combined chemo-radiotherapy in primary central nervous system lymphoma.
    Hematology/oncology and stem cell therapy, 2010, Volume: 3, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Radiotherapy; Radiotherapy Dosage; Regression Analysis; Retrospective Studies; Survival Analysis; Treatment Outcome

2010
Salvage radiotherapy in patients with recurrent or refractory primary or secondary central nervous system lymphoma after methotrexate-based chemotherapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Recurrence; Retrospective Studies; Salvage Therapy; Treatment Outcome

2011
Secondary central nervous system (CNS) involvement in patients with diffuse large B-cell lymphoma: a therapeutic dilemma.
    Annals of hematology, 2011, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Disease Progression; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prognosis; Recurrence; Republic of Korea; Retrospective Studies; Survival Analysis; Young Adult

2011
A nonradiation-containing, intermediate-dose methotrexate regimen for elderly patients with primary central nervous system lymphoma.
    International journal of hematology, 2010, Volume: 92, Issue:4

    Topics: Aged; Antimetabolites; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Female; Humans; Lymphoma; Male; Methotrexate; Methylprednisolone; Middle Aged; Nitrosourea Compounds; Procarbazine; Retrospective Studies

2010
How important is whole brain radiotherapy for treatment of primary CNS lymphoma?
    The Lancet. Oncology, 2010, Volume: 11, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Cytarabine; Disease-Free Survival; Humans; Ifosfamide; Lymphoma; Methotrexate; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors; Survival Rate; Time Factors; Treatment Outcome

2010
Population-based risks of CNS tumors in survivors of childhood cancer: the British Childhood Cancer Survivor Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Dec-20, Volume: 28, Issue:36

    Topics: Adult; Antimetabolites, Antineoplastic; Case-Control Studies; Central Nervous System Neoplasms; Child; Cohort Studies; Genetic Predisposition to Disease; Humans; Injections, Spinal; Meningioma; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Radiotherapy; Risk Factors; United Kingdom

2010
Increasing age at diagnosis and worsening renal function in patients with primary central nervous system lymphoma.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:1

    Topics: Aged; Aging; Central Nervous System Neoplasms; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Diseases; Longitudinal Studies; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Statistics, Nonparametric

2011
Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent patients.
    Pediatric blood & cancer, 2011, Jul-01, Volume: 56, Issue:7

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Immunocompetence; Infant; Lymphoma; Male; Methotrexate; Treatment Outcome

2011
Epstein-Barr virus (EBV)-associated primary central nervous system lymphoma: is incidence of EBV expression associated with median survival time?
    Brain tumor pathology, 2011, Volume: 28, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System; Central Nervous System Neoplasms; Comorbidity; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; In Situ Hybridization; Incidence; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Retrospective Studies; RNA, Viral; Treatment Outcome

2011
Late relapse in primary central nervous system lymphoma: clonal persistence.
    Neuro-oncology, 2011, Volume: 13, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy; Retrospective Studies; Salvage Therapy; Survival Rate; Treatment Outcome

2011
Clinical importance of Bcl-6-positive non-deep-site involvement in non-HIV-related primary central nervous system diffuse large B-cell lymphoma.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; DNA-Binding Proteins; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prognosis; Proto-Oncogene Proteins c-bcl-6; Treatment Outcome

2011
Clinical characteristics and outcome of isolated extracerebral relapses of primary central nervous system lymphoma: a case series.
    Hematological oncology, 2011, Volume: 29, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Recurrence; Treatment Outcome

2011
Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-15, Volume: 17, Issue:8

    Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain; Cell Line, Tumor; Central Nervous System Neoplasms; Female; Humans; Lymphoma, B-Cell; Magnetic Resonance Imaging; Methotrexate; Random Allocation; Rats; Rats, Nude; Rituximab; Survival Analysis; Treatment Outcome; Xenograft Model Antitumor Assays; Yttrium Radioisotopes

2011
Diffuse infiltrating retinoblastoma with central nervous system metastasis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Etoposide; Humans; Hydrocortisone; Infusions, Intravenous; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Retinal Neoplasms; Retinoblastoma; Vincristine

2011
Factors influencing the response to high dose methotrexate-based vincristine and procarbazine combination chemotherapy for primary central nervous system lymphoma.
    Journal of Korean medical science, 2011, Volume: 26, Issue:4

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Contrast Media; Disease-Free Survival; DNA-Binding Proteins; Drug Administration Schedule; Female; Follow-Up Studies; Gadolinium; Humans; Interferon Regulatory Factors; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Odds Ratio; Procarbazine; Prospective Studies; Recurrence; Regulatory Factor X Transcription Factors; Severity of Illness Index; Transcription Factors; Tumor Suppressor Protein p53; Vincristine; X-Box Binding Protein 1

2011
High-dose methotrexate with R-CHOP therapy for the treatment of patients with primary central nervous system lymphoma.
    International journal of hematology, 2011, Volume: 93, Issue:6

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cohort Studies; Cyclophosphamide; Doxorubicin; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Survival Analysis; Treatment Outcome; Vincristine; Young Adult

2011
High-dose methotrexate in patients with primary central nervous system lymphoma: does drug exposure really matter?
    Leukemia & lymphoma, 2011, Volume: 52, Issue:10

    Topics: Central Nervous System Neoplasms; Female; Humans; Male; Methotrexate

2011
Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis.
    German medical science : GMS e-journal, 2011, Volume: 9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Dexamethasone; Disease Progression; Disease-Free Survival; Female; Humans; Ifosfamide; Kaplan-Meier Estimate; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vincristine; Vindesine

2011
Prophylactic intrathecal chemotherapy in primary CNS lymphoma.
    Journal of neuro-oncology, 2012, Volume: 106, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cohort Studies; Disease-Free Survival; Female; Follow-Up Studies; Humans; Injections, Spinal; Karnofsky Performance Status; Lomustine; Lymphoma; Male; Methotrexate; Methylprednisolone; Middle Aged; Neoplasm Recurrence, Local; Neuroprotective Agents; Procarbazine; Retrospective Studies; Young Adult

2012
Relapse of primary central nervous system lymphoma 13 years after high-dose methotrexate-based polychemotherapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2011, Volume: 18, Issue:11

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Recurrence; Remission Induction

2011
Clinical features and treatment outcomes of isolated secondary central nervous system lymphomas in Miyazaki Prefecture.
    International journal of clinical oncology, 2012, Volume: 17, Issue:4

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Prognosis; Recurrence; Rituximab; Treatment Outcome

2012
CNS disease in younger patients with aggressive B-cell lymphoma: an analysis of patients treated on the Mabthera International Trial and trials of the German High-Grade Non-Hodgkin Lymphoma Study Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Age of Onset; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclophosphamide; Doxorubicin; Etoposide; Female; Germany; Humans; International Cooperation; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Medical Oncology; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Grading; Neoplasm Invasiveness; Prednisolone; Prednisone; Rituximab; Societies, Medical; Vincristine; Young Adult

2012
Cognitive functions in primary CNS lymphoma after single or combined modality regimens.
    Neuro-oncology, 2012, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Brain; Central Nervous System Neoplasms; Cognition; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neuropsychological Tests; Quality of Life

2012
The prognostic value of serum methotrexate area under curve in elderly primary CNS lymphoma patients.
    Annals of hematology, 2012, Volume: 91, Issue:8

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Treatment Outcome

2012
High-dose methotrexate and temozolomide associated with intrathecal liposomal cytarabine for the treatment of primary or secondary central nervous system lymphoma: a preliminary experience.
    Clinical neurology and neurosurgery, 2012, Volume: 114, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Cytarabine; Dacarbazine; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Nervous System; Temozolomide

2012
Rituximab significantly improves complete response rate in patients with primary CNS lymphoma.
    Journal of neuro-oncology, 2012, Volume: 109, Issue:2

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Central Nervous System Neoplasms; Female; Follow-Up Studies; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Retrospective Studies; Rituximab; Statistics, Nonparametric; Survival Rate

2012
Isolated central nervous system relapse in a patient with diffuse large B cell lymphoma.
    BMJ case reports, 2012, Jan-23, Volume: 2012

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Diagnostic Imaging; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Procarbazine; Recurrence; Rituximab; Vincristine

2012
Ogilvie's syndrome during chemotherapy with high-dose methotrexate for primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Jul-20, Volume: 30, Issue:21

    Topics: Abdominal Pain; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Colon; Colonic Pseudo-Obstruction; Decompression, Surgical; Dilatation, Pathologic; Female; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Neostigmine; Parasympathomimetics; Risk Factors; Treatment Outcome

2012
[Analysis of the immunohistochemical subtypes and prognosis of primary diffuse large B cell lymphoma of the central nervous system].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2012, Volume: 34, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Forkhead Transcription Factors; Humans; Immunophenotyping; Interferon Regulatory Factors; Ki-67 Antigen; LIM Domain Proteins; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neprilysin; Positive Regulatory Domain I-Binding Factor 1; Prednisone; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Repressor Proteins; Retrospective Studies; Serpins; Survival Rate; Vincristine; Young Adult

2012
[I. Treatment and problem of primary central nerve system lymphoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Humans; Lymphoma; Methotrexate

2012
[II. Primary treatment of CNS lymphoma with high-dose MTX].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemoradiotherapy; Humans; Lymphoma; Methotrexate

2012
Outcomes of the oldest patients with primary CNS lymphoma treated at Memorial Sloan-Kettering Cancer Center.
    Neuro-oncology, 2012, Volume: 14, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Feasibility Studies; Female; Follow-Up Studies; Humans; Karnofsky Performance Status; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Procarbazine; Prognosis; Survival Rate; Time Factors; Vincristine

2012
Post-treatment T1 shortening in primary CNS lymphoma.
    Journal of neuro-oncology, 2013, Volume: 111, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Follow-Up Studies; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Retrospective Studies; Survival Rate; Young Adult

2013
Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma.
    British journal of cancer, 2012, Nov-20, Volume: 107, Issue:11

    Topics: Adult; Aged; Central Nervous System Neoplasms; Female; Genotype; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Mutation, Missense; Survival Analysis; Transcobalamins

2012
Salvage chemoimmunotherapy with rituximab, ifosfamide and etoposide (R-IE regimen) in patients with primary CNS lymphoma relapsed or refractory to high-dose methotrexate-based chemotherapy.
    Hematological oncology, 2013, Volume: 31, Issue:3

    Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cranial Nerve Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Resistance, Neoplasm; Etoposide; Eye Neoplasms; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Kaplan-Meier Estimate; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Peripheral Blood Stem Cell Transplantation; Recurrence; Remission Induction; Retrospective Studies; Rituximab; Salvage Therapy; Survival Analysis; Transplantation, Autologous; Treatment Outcome

2013
Successful treatment of primary central nervous system lymphoma without irradiation in children: single center experience.
    Journal of Korean medical science, 2012, Volume: 27, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Prednisone; Recurrence; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome; Vincristine

2012
Early relapses in patients with primary CNS lymphoma treated with methotrexate-based chemotherapy without consolidating whole brain irradiation.
    Journal of neuro-oncology, 2013, Volume: 112, Issue:2

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemoradiotherapy; Cranial Irradiation; Dexamethasone; Female; Follow-Up Studies; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Remission Induction; Retrospective Studies; Rituximab; Survival Rate

2013
Is intrathecal methotrexate necessary in the treatment of primary CNS lymphoma?
    Journal of neuro-oncology, 2002, Volume: 58, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Case-Control Studies; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Injections, Spinal; Lymphoma; Male; Methotrexate; Middle Aged; Nervous System; Retrospective Studies; Survival Analysis; Treatment Outcome

2002
Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement.
    Ophthalmology, 2002, Volume: 109, Issue:9

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Disease-Free Survival; Eye Neoplasms; Female; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Remission Induction; Retrospective Studies; Safety; Survival Rate; Visual Acuity; Vitreous Body

2002
Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma.
    Cancer, 2002, Aug-01, Volume: 95, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Female; Follow-Up Studies; Humans; Hydrocortisone; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies; Survival Analysis; Time Factors; Treatment Outcome

2002
Treatment of acute lymphoblastic leukemia in Hong Kong children: HKALL 93 study.
    Hematological oncology, 2003, Volume: 21, Issue:1

    Topics: Adolescent; Age Factors; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Hong Kong; Humans; Immunophenotyping; Infant; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Regression Analysis; Salvage Therapy; Time Factors

2003
BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Volume: 9, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Cell Differentiation; Central Nervous System Neoplasms; Cohort Studies; Cyclin-Dependent Kinase Inhibitor p16; DNA-Binding Proteins; Female; Humans; Hyaluronan Receptors; Immunohistochemistry; In Situ Hybridization, Fluorescence; Interferon Regulatory Factors; Lymphoma; Male; Membrane Glycoproteins; Methotrexate; Middle Aged; Neprilysin; Polymerase Chain Reaction; Prognosis; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Syndecan-1; Syndecans; Transcription Factors; Treatment Outcome; Tumor Suppressor Protein p53

2003
Intrathecal chemotherapy alone is inadequate central nervous system prophylaxis in patients with intermediate-grade non-Hodgkin's lymphoma.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prognosis; Risk Factors; Secondary Prevention; Time Factors; Treatment Outcome

2002
Current status and future of relapsed primary central nervous system lymphoma (PCNSL).
    Leukemia & lymphoma, 2003, Volume: 44, Issue:4

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Central Nervous System Neoplasms; Cyclophosphamide; Disease-Free Survival; Etoposide; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Organophosphorus Compounds; Radioimmunotherapy; Recurrence; Rituximab; Time Factors

2003
Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma.
    Ophthalmology, 2003, Volume: 110, Issue:6

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Disease-Free Survival; Eye Neoplasms; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local

2003
Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy.
    Journal of neuro-oncology, 2003, Volume: 63, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Survival Rate; Time Factors

2003
Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: an intent-to-treat analysis.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Nov-15, Volume: 21, Issue:22

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Remission Induction; Safety; Salvage Therapy; Survival Rate; Transplantation, Autologous; Treatment Outcome

2003
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2003, Volume: 38, Issue:7

    Topics: Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Eye Neoplasms; Fluorescein Angiography; Fundus Oculi; Humans; Injections; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Visual Acuity; Vitreous Body

2003
Outcome of children with high-risk acute lymphoblastic leukemia (HR-ALL): Nordic results on an intensive regimen with restricted central nervous system irradiation.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome

2004
CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:1

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child, Preschool; Cohort Studies; Cranial Irradiation; Female; Humans; Infant; Leukemia, T-Cell; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate

2004
Neurocognitive outcomes in primary CNS lymphoma (PCNSL).
    Neurology, 2004, Feb-24, Volume: 62, Issue:4

    Topics: Aged; Central Nervous System Neoplasms; Cognition Disorders; Combined Modality Therapy; Comorbidity; Cranial Irradiation; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neoplasm Invasiveness; Radiation Injuries; Treatment Outcome

2004
Cognitive functions in survivors of primary central nervous system lymphoma.
    Neurology, 2004, Feb-24, Volume: 62, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Attention; Brain; Central Nervous System Neoplasms; Cognition Disorders; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Memory; Methotrexate; Middle Aged; Myelin Sheath; Neuropsychological Tests; Prospective Studies; Quality of Life; Remission Induction; Survivors

2004
Cognitive status and quality of life after treatment for primary CNS lymphoma.
    Neurology, 2004, Feb-24, Volume: 62, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Brain; Carmustine; Case-Control Studies; Central Nervous System Neoplasms; Cognition Disorders; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Hydrocortisone; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylprednisolone; Middle Aged; Myelin Sheath; Neuropsychological Tests; Prospective Studies; Quality of Life; Teniposide

2004
Primary CNS lymphoma: 5-year survival in relation to dosage of methotrexate and radiation.
    Annals of hematology, 2004, Volume: 83, Issue:8

    Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Radiotherapy, Adjuvant; Survival Rate

2004
Systemic anaphylactic reaction following intrathecal administration of methotrexate in adult patient with primary central nervous system lymphoma.
    American journal of hematology, 2004, Volume: 75, Issue:4

    Topics: Anaphylaxis; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged

2004
Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:2

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzamides; Blast Crisis; Bone Marrow; Central Nervous System Neoplasms; Cytarabine; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction

2004
Primary non-Hodgkin's lymphoma of the CNS treated with CHOD/BVAM or BVAM chemotherapy before radiotherapy: long-term survival and prognostic factors.
    International journal of radiation oncology, biology, physics, 2004, Jun-01, Volume: 59, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Survival Analysis; Vincristine

2004
Primary central nervous system lymphoma with testicular relapse.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2004, Volume: 16, Issue:3

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Recurrence; Testicular Neoplasms

2004
Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas.
    British journal of haematology, 2004, Volume: 126, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; CpG Islands; Drug Resistance, Neoplasm; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Membrane Transport Proteins; Methotrexate; Methylation; Middle Aged; Predictive Value of Tests; Prevalence; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA

2004
Treatment of relapsed central nervous system lymphoma with high-dose methotrexate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-01, Volume: 10, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cranial Irradiation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Treatment Outcome

2004
The treatment of primary central nervous system lymphoma in 122 immunocompetent patients: a population-based study of successively treated cohorts from the British Colombia Cancer Agency.
    Cancer, 2005, Mar-01, Volume: 103, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Prednisone; Survival Rate; Vincristine

2005
[Treatment results in children with standard-risk acute lymphoblastic leukemia. Report of the Polish Pediatric Leukemia/Lymphoma Study Group].
    Przeglad lekarski, 2004, Volume: 61 Suppl 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Risk Factors; Secondary Prevention; Survival Analysis; Testicular Neoplasms; Time Factors; Treatment Outcome; Vincristine

2004
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
    Journal of neuro-oncology, 2005, Volume: 71, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous System Neoplasms; Choline; Creatine; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Lactic Acid; Lipid Metabolism; Lymphoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Protons; Survival Analysis

2005
Preliminary individual adjuvant chemotherapy for primary central nervous system lymphomas based on the expression of drug-resistance genes.
    Brain tumor pathology, 2004, Volume: 21, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, MDR; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Protein 2; Radiography; Reverse Transcriptase Polymerase Chain Reaction

2004
Modified ProMACE-MOPP hybrid regimen with moderate-dose methotrexate for patients with primary CNS lymphoma.
    Annals of hematology, 2005, Volume: 84, Issue:7

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Leukopenia; Lymphoma; Male; Mechlorethamine; Methotrexate; Middle Aged; Pneumonia; Prednisone; Procarbazine; Retrospective Studies; Sepsis; Vincristine

2005
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
    Neurology, 2005, Mar-08, Volume: 64, Issue:5

    Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine

2005
Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Apr-01, Volume: 23, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Female; Health Status; Humans; Lymphoma, T-Cell; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Survival Analysis

2005
Myelopathy due to intrathecal chemotherapy: report of six cases.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:5

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Folic Acid Antagonists; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

2005
Relapse of primary CNS lymphoma after more than 10 years in complete remission.
    Journal of neurology, 2005, Volume: 252, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Dacarbazine; Humans; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Recurrence, Local; Procarbazine; Temozolomide; Vincristine

2005
Primary central nervous system lymphoma: a single-centre experience of 55 unselected cases.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 2005, Volume: 17, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Survival Analysis; Treatment Outcome

2005
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
    British journal of haematology, 2005, Volume: 131, Issue:2

    Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Chemoprevention; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Patient Selection; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Surveys and Questionnaires; United Kingdom

2005
Cognitive functions in primary central nervous system lymphoma patients treated with chemotherapy and stem cell transplantation: preliminary findings.
    Clinical advances in hematology & oncology : H&O, 2003, Volume: 1, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cognition Disorders; Cytarabine; Drug Screening Assays, Antitumor; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome

2003
Effect of oral colestimide on the elimination of high-dose methotrexate in patients with primary central nervous system lymphoma--case report.
    Neurologia medico-chirurgica, 2005, Volume: 45, Issue:12

    Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Epichlorohydrin; Humans; Imidazoles; Lymphoma; Male; Methotrexate; Middle Aged; Resins, Synthetic

2005
Primary central nervous system lymphoma in a renal transplant recipient with Bardet-Biedl syndrome.
    Transplantation proceedings, 2005, Volume: 37, Issue:10

    Topics: Adult; Antineoplastic Agents; Bardet-Biedl Syndrome; Central Nervous System Neoplasms; Combined Modality Therapy; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lymphoma; Methotrexate; Postoperative Complications

2005
Low-grade central nervous system lymphoma: clarity through a hazy lens.
    Annals of neurology, 2006, Volume: 59, Issue:5

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; T-Lymphocytes

2006
Primary central nervous system lymphomas (PCNSL): MRI response criteria revised.
    Neurology, 2006, Apr-25, Volume: 66, Issue:8

    Topics: Central Nervous System Neoplasms; Follow-Up Studies; Humans; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Neoplasm Recurrence, Local; Remission Induction; Retrospective Studies

2006
Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factors.
    Journal of neuro-oncology, 2006, Volume: 80, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Karnofsky Performance Status; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Salvage Therapy; Survival Analysis; Tomography, X-Ray Computed; Treatment Outcome

2006
Central nervous system recurrence in adult patients with acute lymphoblastic leukemia: frequency and prognosis in 467 patients without cranial irradiation for prophylaxis.
    Cancer, 2006, Jun-15, Volume: 106, Issue:12

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Hydrocortisone; Incidence; Lactate Dehydrogenases; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis

2006
Spontaneously relapsing and remitting primary CNS lymphoma in an immunocompetent 45-year-old man.
    Journal of neuro-oncology, 2006, Volume: 80, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Central Nervous System Neoplasms; Humans; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Regression, Spontaneous; Procarbazine; Treatment Outcome; Vincristine

2006
Long-term follow-up of high-dose methotrexate-based therapy with and without whole brain irradiation for newly diagnosed primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Oct-01, Volume: 24, Issue:28

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Central Nervous System Neoplasms; Cohort Studies; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Treatment Outcome

2006
Management of gestational trophoblastic neoplasia with metastasis to the central nervous system: A 12-year review at the Philippine General Hospital.
    The Journal of reproductive medicine, 2006, Volume: 51, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Etoposide; Female; Gestational Trophoblastic Disease; Humans; Injections, Spinal; Medical Records; Methotrexate; Middle Aged; Neoplasm Metastasis; Philippines; Pregnancy; Retrospective Studies; Survival Analysis; Uterine Neoplasms; Vincristine

2006
Methotrexate based chemotherapy and deferred radiotherapy for primary central nervous system lymphoma (PCNSL): single institution experience.
    Journal of neuro-oncology, 2007, Volume: 82, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Radiotherapy; Time Factors; Treatment Outcome; Vincristine

2007
The role of intrathecal chemotherapy prophylaxis in patients with diffuse large B-cell lymphoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cytarabine; Female; Follow-Up Studies; Humans; Incidence; Injections, Spinal; Kaplan-Meier Estimate; London; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Prognosis; Retrospective Studies; Time Factors; Treatment Outcome

2007
Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
    Leukemia & lymphoma, 2006, Volume: 47, Issue:12

    Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Humans; Leucovorin; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Risk

2006
Case report of a patient with primary central nervous system lymphoma treated with radioimmunotherapy.
    Clinical lymphoma & myeloma, 2006, Volume: 7, Issue:3

    Topics: Adult; Antibodies, Monoclonal; Blood-Brain Barrier; Brain; Central Nervous System Neoplasms; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Prognosis; Radioimmunotherapy; Remission Induction

2006
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2006, Volume: 47, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Facial Paralysis; Humans; Injections, Spinal; Male; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Risk Factors; Sagittal Sinus Thrombosis; Vincristine

2006
High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma.
    Neuro-oncology, 2007, Volume: 9, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biopsy; Brain Neoplasms; Central Nervous System Neoplasms; Female; Humans; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Recurrence; Stereotaxic Techniques

2007
Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report.
    Journal of neuro-oncology, 2007, Volume: 84, Issue:1

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Blood-Brain Barrier; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Magnetic Resonance Imaging; Male; Methotrexate; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Sarcoma, Myeloid; Treatment Outcome

2007
Testicular relapse of primary central nervous system lymphoma.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:5

    Topics: Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Recurrence; Remission Induction; Testicular Neoplasms; Treatment Outcome

2007
Toothache, paresthesia, and Horner syndrome: an unusual presentation of disseminated Burkitt's lymphoma.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2007, Volume: 65, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Cyclophosphamide; Dry Socket; Horner Syndrome; Humans; Male; Mandibular Neoplasms; Methotrexate; Middle Aged; Paresthesia; Remission Induction; Tooth Extraction; Toothache; Vincristine

2007
Central nervous system anaplastic large cell lymphoma in an adult: successful treatment with a combination of radiation and chemotherapy.
    Military medicine, 2007, Volume: 172, Issue:6

    Topics: Adult; Antineoplastic Agents; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Procarbazine; Vincristine

2007
Methotrexate concentrations in cerebrospinal fluid and serum, and the risk of central nervous system relapse in children with acute lymphoblastic leukaemia.
    Anti-cancer drugs, 2007, Volume: 18, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Logistic Models; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk

2007
18F-FDG PET/CT in primary central nervous system lymphoma in HIV-negative patients.
    Nuclear medicine communications, 2007, Volume: 28, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimetabolites, Antineoplastic; Antineoplastic Agents; Central Nervous System Neoplasms; Cohort Studies; Female; Fluorodeoxyglucose F18; HIV Seronegativity; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Rituximab

2007
Combined immunochemotherapy with reduced whole-brain radiotherapy for newly diagnosed primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Oct-20, Volume: 25, Issue:30

    Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Immunotherapy; Lymphoma; Male; Methotrexate; Middle Aged; Procarbazine; Prospective Studies; Remission Induction; Rituximab; Treatment Outcome; Vincristine

2007
Perioperative complications of blood brain barrier disruption under general anesthesia: a retrospective review.
    Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Carotid Arteries; Central Nervous System Neoplasms; Electrocardiography; Female; Gadolinium; Humans; Hypertonic Solutions; Infusions, Intra-Arterial; Intraoperative Complications; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Postoperative Complications; Postoperative Nausea and Vomiting; Retrospective Studies; Seizures; Tachycardia; Tomography, X-Ray Computed; Vertebral Artery

2008
High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system.
    Haematologica, 2008, Volume: 93, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Stem Cell Transplantation; Transplantation, Autologous; Treatment Outcome

2008
Efficacy and tolerability of high-dose methotrexate in central nervous system positive or relapsed lymphoproliferative disease following liver transplant in children.
    British journal of haematology, 2008, Volume: 140, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Liver Transplantation; Lymphoma, Non-Hodgkin; Male; Methotrexate; Postoperative Complications; Tomography, X-Ray Computed

2008
Maculopathy in patients with primary CNS lymphoma treated with chemotherapy in conjunction with blood-brain barrier disruption.
    The British journal of ophthalmology, 2008, Volume: 92, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Carboplatin; Central Nervous System Neoplasms; Eye Neoplasms; Female; Humans; Infusions, Intravenous; Injections; Lymphoma, Non-Hodgkin; Macula Lutea; Male; Methotrexate; Middle Aged; Retinal Diseases; Retrospective Studies; Tomography, X-Ray Computed; Vitreous Body

2008
Results of treatment of 112 cases of primary CNS lymphoma.
    Japanese journal of clinical oncology, 2008, Volume: 38, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Cognition; Cranial Irradiation; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Kaplan-Meier Estimate; Karnofsky Performance Status; Leucovorin; Lymphoma; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasm Staging; Prednisone; Procarbazine; Radiotherapy, Adjuvant; Retrospective Studies; Salvage Therapy; Treatment Outcome; Vincristine

2008
The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia.
    Blood, 1995, Sep-15, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Humans; Infusions, Intravenous; Injections, Spinal; Life Tables; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Factors; Survival Rate; Vincristine

1995
[Central nervous system relapses in acute lymphoblastic leukemia and different methods of prophylaxis].
    Acta haematologica Polonica, 1995, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Risk Factors; Survival Analysis

1995
An intensive re-treatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Clinical Protocols; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Recurrence; Remission Induction; Time Factors

1995
Second malignant tumors after elective end of therapy for a first cancer in childhood: a multicenter study in Italy.
    International journal of cancer, 1994, Nov-15, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Central Nervous System Neoplasms; Child; Cranial Irradiation; Cross-Sectional Studies; Female; Follow-Up Studies; Hodgkin Disease; Humans; Incidence; Injections, Spinal; Italy; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasms, Second Primary; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Registries; Risk Factors; Wilms Tumor

1994
Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:12

    Topics: Absenteeism; Adolescent; Analysis of Variance; Central Nervous System Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Leukemia; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Neuropsychological Tests

1994
Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.
    Journal of neurosurgery, 1994, Volume: 81, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Remission Induction; Survival Rate; Treatment Outcome

1994
M-Bacod as first treatment for primary CNS lymphoma.
    Neurology, 1996, Volume: 46, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Dexamethasone; Doxorubicin; Humans; Leucovorin; Lymphoma; Methotrexate; Middle Aged; Vincristine

1996
Therapy of primary CNS lymphoma with methotrexate-based chemotherapy and deferred radiotherapy: preliminary results.
    Neurology, 1996, Volume: 46, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cranial Irradiation; Cyclophosphamide; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Treatment Outcome; Vincristine

1996
Carboxypeptidase G2 rescue after high-dose methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:7

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; gamma-Glutamyl Hydrolase; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects

1996
[Long-term survivor (15 years) following central nervous system involvement in B-cell lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1996, Volume: 37, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Humans; Lymphoma, B-Cell; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Invasiveness; Prednisolone; Survivors; Vincristine

1996
Intravitreal methotrexate as an adjunctive treatment of intraocular lymphoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:9

    Topics: Aged; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Diuretics, Osmotic; Eye Neoplasms; Female; Humans; Injections; Lymphoma; Male; Mannitol; Methotrexate; Middle Aged; Radiotherapy, Adjuvant; Survival Rate; Visual Acuity; Vitreous Body

1997
Prognostic significance of coexistent bulky metastatic central nervous system disease in patients with leptomeningeal metastases.
    Archives of neurology, 1997, Volume: 54, Issue:11

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Predictive Value of Tests; Prognosis; Retrospective Studies; Survival Analysis

1997
Long-term survival in primary CNS lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Follow-Up Studies; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Remission Induction; Survival Analysis; Treatment Outcome

1998
Systemic chemotherapy alone for patients with non-acquired immunodeficiency syndrome-related central nervous system lymphoma: a pilot study of the BOMES protocol.
    Cancer, 1998, May-15, Volume: 82, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Disease Progression; Etoposide; Female; Humans; Lymphoma, AIDS-Related; Male; Methotrexate; Methylprednisolone Hemisuccinate; Middle Aged; Pilot Projects; Prospective Studies; Survival Rate; Treatment Outcome; Vincristine

1998
Successful treatment of non-Hodgkin's lymphoma of the central nervous system with BMPD chemotherapy followed by radiotherapy.
    Leukemia & lymphoma, 1998, Volume: 30, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Dexamethasone; Female; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Procarbazine; Radiography; Treatment Outcome

1998
Chemotherapy is effective as early treatment for primary central nervous system lymphoma.
    Journal of neurology, 1999, Volume: 246, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Dexamethasone; Doxorubicin; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Vincristine

1999
[A case of non-Hodgkin lymphoma in the central nervous system, developing during treatment of galactorrhea amenorrhea syndrome].
    Rinsho shinkeigaku = Clinical neurology, 1999, Volume: 39, Issue:11

    Topics: Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Galactorrhea; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Methotrexate; Prednisone; Syndrome; Treatment Outcome; Vincristine; Whole-Body Irradiation

1999
Primary central nervous system lymphoma: a clinicopathological study of 28 cases.
    Hematological oncology, 2000, Volume: 18, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Cognition Disorders; Combined Modality Therapy; Cytarabine; Female; Follow-Up Studies; Humans; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Spinal Cord Neoplasms; Survival Analysis; Time Factors

2000
Methotrexate concentration in cerebrospinal fluid of the space created by tumor removal.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:6

    Topics: Area Under Curve; Central Nervous System Neoplasms; Combined Modality Therapy; Glioblastoma; Humans; Methotrexate

2000
Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Glioblastoma; Humans; Methotrexate; Nimustine; Valproic Acid

2000
Incidence and risk factors of central nervous system relapse in histologically aggressive non-Hodgkin's lymphoma uniformly treated and receiving intrathecal central nervous system prophylaxis: a GELA study on 974 patients. Groupe d'Etudes des Lymphomes de
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:6

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Female; Humans; Injections, Spinal; Logistic Models; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Multivariate Analysis; Prognosis; Risk Factors; Secondary Prevention; Survival Analysis

2000
Primary central nervous system lymphoma and subcutaneous metastases.
    Journal of neuro-oncology, 2000, Volume: 47, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Skin; Skin Neoplasms

2000
Primary central nervous system lymphoma 1991-1997: outcome and late adverse effects after combined modality treatment.
    Cancer, 2001, Jan-01, Volume: 91, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Infusions, Intravenous; Lymphoma; Male; Methotrexate; Middle Aged; Radiotherapy; Retrospective Studies; Survival Analysis; Treatment Outcome

2001
Combined treatment with high-dose methotrexate, vincristine and procarbazine, without intrathecal chemotherapy, followed by consolidation radiotherapy for primary central nervous system lymphoma in immunocompetent patients.
    Oncology, 2001, Volume: 60, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Feasibility Studies; Female; Humans; Lymphoma; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Procarbazine; Prospective Studies; Radiotherapy, Adjuvant; Survival Analysis; Treatment Outcome; Vincristine

2001
High-dose methotrexate for primary CNS lymphoma in the elderly.
    Neuro-oncology, 2000, Volume: 2, Issue:1

    Topics: Aged; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Lymphoma; Male; Methotrexate; Retrospective Studies; Survival Analysis

2000
Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study.
    Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 71, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Female; Humans; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Pilot Projects; Survival Analysis; Treatment Outcome

2001
Primary central nervous system T-cell lymphoma.
    Neurology, 2001, Aug-28, Volume: 57, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cytarabine; Fatal Outcome; Humans; Lymphoma, T-Cell; Male; Methotrexate; Neoplasm Recurrence, Local; Prognosis

2001
High-dose methotrexate for isolated central nervous system relapse in patients with testicular non-Hodgkin's lymphoma.
    Clinical lymphoma, 2001, Volume: 2, Issue:2

    Topics: Aged; Aged, 80 and over; Brain; Brain Neoplasms; Central Nervous System Neoplasms; Disease Progression; Disease-Free Survival; Humans; Injections, Intravenous; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Recurrence; Testicular Neoplasms

2001
5. Report on workshop: Primary CNS lymphoma.
    Annals of hematology, 2001, Volume: 80 Suppl 3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Gene Rearrangement; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Methotrexate; Radiation Injuries; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome

2001
Neuropsychologic impairment in adult bone marrow transplant candidates.
    Cancer, 1992, Nov-01, Volume: 70, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Attention; Bone Marrow Transplantation; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Cognition Disorders; Cranial Irradiation; Cytarabine; Female; Humans; Leukemia; Lymphoma; Male; Memory; Methotrexate; Middle Aged; Neuropsychology; Psychomotor Performance; Regression Analysis; Whole-Body Irradiation

1992
Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate.
    Cancer, 1992, Oct-01, Volume: 70, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Cerebral Cortex; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Injections, Spinal; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

1992
Intracerebral (parenchymal) infusion of methotrexate: report of a case.
    Journal of neuro-oncology, 1992, Volume: 12, Issue:2

    Topics: Adult; Brain; Central Nervous System Neoplasms; Cerebral Ventricles; Female; Humans; Infusions, Parenteral; Leukemia, Myeloid, Acute; Methotrexate; Tomography, X-Ray Computed

1992
[Late recurrence (11 years) in a case of ALL. Recurrence or a second disease?].
    Sangre, 1992, Volume: 37, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Diagnosis, Differential; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Vincristine

1992
Intensive weekly combination chemotherapy for patients with intermediate-grade and high-grade non-Hodgkin's lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Prednisone; Survival Analysis; Vincristine

1991
Malignant lymphomas in HIV-seropositive patients. Frequency, features, and prognosis. Report on 31 cases.
    Klinische Wochenschrift, 1991, Oct-02, Volume: 69, Issue:15

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Female; HIV Seropositivity; Hodgkin Disease; Humans; Leucovorin; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Vincristine

1991
Cognitive function in children with leukemia. Effect of radiation dose and time since irradiation.
    Cancer, 1991, Nov-01, Volume: 68, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Combined Modality Therapy; Cranial Irradiation; Educational Status; Female; Humans; Infant; Intelligence; Male; Methotrexate; Motor Skills; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Remission Induction; Time Factors

1991